Program for PET Image Alignment: Effects on Calculated ... - CiteSeerX
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Program for PET Image Alignment: Effects on Calculated ... - CiteSeerX
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Program for PET Image Alignment: Effects on Calculated Differences in Cerebral Metabolic Rates for Glucose Robert L. Phillips, Edythe D. London,
Jonathan
Neuropharmacology
Research
Laboratory,
Addiction
M. Links, and Nicola G. Cascella Center, National
Institute
on Drug Abuse, Baltimore,
Maryland
and Division ofNuclear Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland
A program was developed to align positron emission to mography images from multiple studies on the same sub
ject. The program allowed alignment of two images with a fineness of one-tenth the width of a pixel. The indications
and effects of misalignment were assessed in eight sub
structure or in the whole brain. Since the activity dis tribution over the structure of interest may be hetero geneous, it is important to sample the same anatomic site in both the test and the retest studies. Even the best human-use head holders cannot completely eliminate
study on the effects of cocaine on regional cerebral met abolic rates for glucose. Visualexamination of a difference image provided a sensitive and accurate tool for assessing image alignment. Image alignment within 2.8 mm was essential to reduce variabilityof measured cerebral meta bolicrates for glucose. Misalignmentby this amount intro
head motion and misalignment (8). Therefore, some means of detection or, preferably, correction for this motion is necessary. We have developed methodology for alignment of images from multiple PET studies. Our method reduces artifacts in the regional measurements due to move ment of the subject between serial scans. We have
duced errors on the order of 20% in the computed meta bolic rate for glucose. These errors propagate to the
assessed the magnitude of spurious effects due to small (
