Repairing segmental defect with a composite ...

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Repairing segmental defect with a composite ...

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implanted with a composite associating resorbable collagen membrane plus micro ... succeeded in reconstruct a large segmental defect in weight bearing and.

Key Engineering Materials Vols. 361-363 (2008) pp. 1245-1248 online at http://www.scientific.net © (2008) Trans Tech Publications, Switzerland Online available since 2007/11/20

Repairing Segmental Defect with a Composite Associating Collagen Membrane and MBCP® Combined with Total Bone Marrow Graft in Irradiated Bone Defect: an Experimental Study in Rabbit. F. Jegoux1,a, E. Aguado2,5,b, R. Cognet2,c, O. Malard1,d, F. Moreau3,e, G. Daculsi1,4,f and E. Goyenvalle2,5,g 1

INSERM U791, University of Nantes France ENVN, BBTOCex, Nantes Veterinary School, France 3 Biomatlante SAS, Vigneux de Bretagne, France 4 CIC-CIT, Bordeaux University Hospital, France 5 INSERM 0335, University of Angers, France a [email protected], [email protected], [email protected], d [email protected], [email protected], fgdaculsi@ univ-nantes.fr, g [email protected] 2

Keywords: calcium phosphate, bone marrow, radiotherapy, segmental bone defect, animal model, tissue engineering

Abstract. The aim of this study was to study bone marrow quality from various location and species for reconstruction of segmental critical size defect in irradiated weigh bearing bone. Sample of bone marrow aspirates from rabbits and Beagle dog were analyzed. Rabbits were implanted with a composite associating resorbable collagen membrane plus micro macroporous biphasic calcium phosphate (MBCP®) and autologous bone marrow (BM) injected after irradiation. Bone marrow samples were found to be significantly less rich in tibia than in humerus and ilium in Dog and less rich in Dog than in Rabbit (p