Apr 10, 2016 - ChinYu Lin, MD. ; John Silberbauer, MD(Res). ; YennJiang Lin, MD, PhD. ; MenTzung Lo, PhD ; Chen. Lin, PhD ; HsiangChih Chang, PhD ...
2016/4/10 American College of Cardiology Foundation | JACC: Clinical Electrophysiology | Simultaneous Amplitude Frequency Electrogram Transformation (…
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Simultaneous Amplitude Frequency Electrogram Transformation (SAFET) Mapping to Identify Ventricular Tachycardia Arrhythmogenic Potentials in Sinus Rhythm ONLINE FIRST ChinYu Lin, MDa,b; John Silberbauer, MD(Res)c,d; YennJiang Lin, MD, PhDa,b; MenTzung Lo, PhDe; Chen Lin, PhDe; HsiangChih Chang, PhDe; ShihLin Chang, MD, PhDa,b; LiWei Lo, MD, PhDa,b; YuFeng Hu, MD, PhDa,b; FaPo Chung, MDa,b; JoNan Liao, MDa,b; YunYu Chen, MPHa; ChunWang Chiou, MDa,b; ShihAnn Chen, MDa,b; Paolo Della Bella, MDc
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[+] Author Information JACCCEP. 2016;():. doi:10.1016/j.jacep.2016.01.013
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Abstract Objectives This study sought to develop a novel automated technique, simultaneous amplitude frequency electrogram transformation (SAFET), to identify ventricular tachycardia (VT) isthmuses by analysis of sinus rhythm arrhythmogenic potentials (AP).
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Background Substrate ablation is useful for patients with scarrelated hemodynamically unstable VT; however, the accuracy of different approaches remains inadequate, varying from targeting late potentials to full scar homogenization.
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Methods Highdensity ventricular mapping was performed in 3 groups: 1) 18 normal heart control subjects; 2) 10 ischemic patients; and 3) 8 nonischemic VT patients. In VT patients, isthmus sites were characterized using entrainment responses. Sinus rhythm right ventricle/left ventricle endocardial and epicardial electrograms underwent HilbertHuang spectral analysis and were displayed as 3dimensional SAFET maps. AP and their relation to the VT isthmus sites were studied.
Substrate Mapping for Ventricular Tachycardia: Assumptions and Misconceptions
Results AP were defined by a cutoff value of 3.08 Hz mV using normal heart control subjects. Receiver operating characteristics showed that VT isthmus sites were best identified using SAFET mapping (p < 0.001) as compared with bipolar and unipolar scar and late potential mapping with an optimal cutoff value of 3.09 Hz mV, allowing identification of 100% of the 34 mapped VT isthmuses, compared with 68% using late potentials. There was no significant difference between sinus rhythm and paced SAFET values. Abnormal SAFET areas involved about onequarter of the scar total area.
Electrophysiological Predictors of Transplantation and Left Ventricular Assist DeviceFree Survival in Patients With Nonischemic Cardiomyopathy Undergoing Ventricular Tachycardia Ablation
Conclusions Automated electrogram analysis using 3dimensional SAFET mapping allows rapid and objective identification of AP that reliably detect VT isthmuses. The results suggest that SAFET mapping is good alternative strategy to late potential mapping in identifying VT isthmuses and allows reduced ablation as compared to scar homogenization.
Perspectives COMPETENCY IN MEDICAL KNOWLEDGE: Automated electrogram timefrequency 3D SAFET mapping allows objective identification of mappable VT isthmuses in patients with structural heart disease. The technique also provides an alternative endpoint of VT ablation by postablation remapping. TRANSLATIONAL OUTLOOK: Automated 3D SAFET mapping provides a good alternative choice for VT ablation in structural heart patients. Further headto head comparison with other substratebased ablation techniques in mappable and unmappable VT to define acute and longterm success rates is warranted.
http://electrophysiology.onlinejacc.org/article.aspx?articleID=2511381#tab1
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JACCCEP. 2015;1(5):341352. doi:10.1016/j.jacep.2015.09.001.
JACCCEP. 2015;1(5):398407. doi:10.1016/j.jacep.2015.07.005. Prognostic Value of Scar Imaging for Substrate Ablation of Ventricular Tachycardia: Fact or Fiction?∗ JACCCEP. 2015;1(5):366368. doi:10.1016/j.jacep.2015.09.002. [+] View More
Related Topics Heart Rhythm Disorders Interventional
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2016/4/10 American College of Cardiology Foundation | JACC: Clinical Electrophysiology | Simultaneous Amplitude Frequency Electrogram Transformation (… PubMed Articles
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Highdensity mapping of ventricular scar: a comparison of ventricular tachycardia (VT) supporting channels with channels that do not support VT. Circ Arrhythm Electrophysiol 2014;7(1):908. Relationship between sinus rhythm late activation zones and critical sites for scar related ventricular tachycardia: systematic analysis of isochronal late activation mapping. Circ Arrhythm Electrophysiol 2015;8(2):3909. View More Results provided by: Advertisement
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