T-lymphocyte CREB as a potential biomarker of response to ...
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T-lymphocyte CREB as a potential biomarker of response to ...
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ARTICLE
T-lymphocyte CREB as a potential biomarker of response to antidepressant drugs Shinn-Won Lim1, Seonwoo Kim2, Bernard J. Carroll3 and Doh Kwan Kim1,4 1
Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea Biostatistics Unit, Samsung Biomedical Research Institute, Seoul, Korea 3 Pacific Behavioral Research Foundation, Carmel, CA, USA 4 Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2
Abstract Response to drug treatment of major depression is variable and biomarkers of response are needed. Cyclic AMP response element binding protein (CREB) is considered a key mediator of antidepressant drug effect. We studied CREB in T-lymphocytes as a potential predictor of response to a selective serotonin reuptake inhibitor (SSRI) in 69 Korean depressed patients. We determined total CREB (tCREB), phosphorylated CREB (pCREB) and CREDNA binding using immunoblot and electrophoretic mobility shift assays, at baseline and after 6 wk treatment. Thirty-four healthy controls were also studied. The rate of response was 36 of 69 cases (52 %). Baseline levels of tCREB and pCREB were lower in the total depressed group compared to controls (p=0.044 and p
