Additional file 1: Table S1. Slit3 expression and

Additional file 1: Table S1. Slit3 expression and patient characteristics in cohort 1 Patient#

Age

1

49

M

YES

2 3 4

68 65 38

M F F

YES YES YES

5

47

F

YES

6

67

NA

NA

Prior liver directed treatment SURGERY+ RFA/ MICROWAV NO NO NO RESECTION/ RFA NO

7

50

F

YES

8 9 10 11 12 13 14

69 34 50 52 42 65 46

M M M M M M M

15

43

16

Gende HBV r

MicroSlit3 Tumor Distant DifferenCirrhosis vascular Stage expressio size metastasis tiation invasion n

MODERATE

NO

7.5

NO

4

Lung

0.516

WELL MODERATE MODERATE

NO YES YES

7 5.5 5

NO NO YES

1 1 2

3.008 1.660 1.515

POOR

NO

7

YES

4

NA

NA

12

NA

NA

NO

NA

NO

4

NO

4

YES YES NA NO YES NO YES

NO NO TOCE NO NO NO NO

MODERATE NA MODERATE MODERATE MODERATE WELL MODERATE

YES NO NO NO NO NO NO

17 22 8 2.5 5 5 5.5

YES NO NO NO NO NO NO

2 1 1 3 1 1 1

M

YES

NO

POOR

YES

8.5

YES

4

64

M

NO

NO

WELL

NO

10

YES

4

17

58

M

YES

NA

NO

7.5

YES

4

18

46

M

WELL

NO

6

NO

1

No

6.126

19 20 21 22 23

55 41 53 71 56

M NA M F M

NO SURGERY+ YES RFA/ MICROWAV NA NO NA NO YES NO NA NO YES NO

No No No Lung, Splenic NA Lung, Brain No No No No No No No Bone, Brain, Lung Colon, Lung Lung

WELL NA WELL NA WELL

NO YES YES NO NO

15 9 4.8 10 6.5

YES NA NO YES NO

4 NA 1 2 1

0.568 0.232 1.798 0.804 6.139

24

47

M

YES

NO

POOR

YES

14

NO

4

25

54

M

YES

NO

NA

NO

5

YES

4

26

56

M

YES

NO

MODERATE

NO

17

YES

4

27

43

M

YES

NO

MODERATE

NO

8

YES

4

28 29 30 31 32 33 34 35

48 67 68 64 29 51 44 49

M M M M M M M M

YES YES NA YES YES YES YES YES

TOCE NO NO NO NO NO NO NO

MODERATE NA MODERATE NA MODERATE MODERATE WELL NA

NO NO NO NO NO YES NO YES

17 6 10 4 3.8 8 7 4

NO NO YES NO NO NO NO NO

3 4 3 1 1 1 1 4

36

64

M

YES

NO

MODERATE

NO

13

YES

4

37 38 39 40

42 60 52 63

M M M F

NO YES NO YES

NO NO NO NO

MODERATE NA MODERATE MODERATE

NO YES YES YES

11 20 2.9 4.5

YES NO YES NO

2 1 4 1

Brain, Lung NA No No No Lung, Liver Lung Lung, Adrenal Lung, Brain No Lung Lymph node No No No No Pleura, Lung Lung, Bone, Peritoneal No No Lung No

1.643 0.518 1.635 0.325 0.833 1.142 7.797 0.547 1.627 1.579 1.334 1.230 0.655

1.243 9.455 1.638 0.579 0.026 0.272 0.474 1.165 1.248 0.603 0.756 1.828 0.516 1.975 1.175 0.062 1.927

Additional file 1: Table S2: Slit3 expression and patient characteristics in cohort 2 Patient#

Age

Gender

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

65 82 79 65 77 60 65 71 60 60 66 65 57 55 67 68 57 63 61 55 46 47 78 55 41

M M M M M M F M M M M F M M M M F F M M F M M M F

Tumor size 13 10 7.5 4.5 3.5 14 1.9 6 11 2.8 8 8.5 2 15 10.5 9.5 8 2.5 2.5 4 17 14 10 7.5 6.5

Slit3 expression 2.336 0.596 4.441 0.252 6.342 0.189 1.098 0.5724 0.3035 1.5337 1.9656 1.95E-03 1.2346 0.2242 0.4993 0.546 1.1219 1.8063 0.9924 0.463 0.4503 0.568 0.5897 1.3168 0.1635