Cross-Validation of a New Procedure for Early ... - Semantic Scholar
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Cross-Validation of a New Procedure for Early ... - Semantic Scholar
established the sensitivity of our procedure. in this study, we sought to cross-validate our earlier work by comparing short-term smoking abstinence due to ...
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Cross-Validation of a New Procedure for Early Screening of Smoking Cessation Medications in Humans KA Perkins1, C Lerman2, CA Fonte1, M Mercincavage1, ML Stitzer3, KNR Chengappa1 and A Jain1 Brief procedures for evaluating medication efficacy may reveal which candidate drugs warrant further testing in clinical trials and which do not. We previously carried out a study of smoking abstinence, involving the nicotine patch, and established the sensitivity of our procedure. In this study, we sought to cross-validate our earlier work by comparing short-term smoking abstinence due to varenicline (relative to placebo) in smokers with high intrinsic quit interest (n = 57) and those with low intrinsic quit interest (n = 67). All the subjects were randomly assigned to either abstinence reinforcement ($12/day) or no reinforcement. In a crossover design, all the subjects participated in two 3-week phases: ad libitum smoking (week 1), dose run-up of varenicline (1.0 mg b.i.d.) or placebo (week 2), and quit attempt on medication verified daily by carbon monoxide
