Expression levels of TWIST1 are associated with the ...
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Expression levels of TWIST1 are associated with the ...
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EXPERIMENTAL AND THERAPEUTIC MEDICINE 8: 1489-1493, 2014
Expression levels of TWIST1 are associated with the clinicopathological stage of B‑cell non‑Hodgkin lymphoma CUNDONG JIA1, LIPING LIANG2, LILI YANG2, FENG ZHAO2 and JINGPING BAI3 Departments of 1Medical Oncology, 2Pathology and 3Bone Oncology, The Affiliated Tumor Hospital of Xinjiang Medical University, Ürümqi, Xinjiang 830011, P.R. China Received February 10, 2014; Accepted July 1, 2014 DOI: 10.3892/etm.2014.1962 Abstract. The aim of the present study was to investigate the expression level of TWIST1 in B‑cell non‑Hodgkin lymphoma (BNHL) and its association with the clinicopathological characteristics of BNHL. Expression levels of TWIST1 were analyzed in patients with BNHL (n=45) and lymphadenosis (n=21) using immunohistochemical staining and western blot analysis. In addition, the mRNA expression levels of TWIST1 in the peripheral blood were detected by fluorescent quantitative polymerase chain reaction. The positive rate of TWIST1 expression in the BNHL tissue was 82.2%, which was significantly higher compared with the lymphadenosis tissue (5%; P
