A virtual opening of the Australian Translational Medicinal Chemistry Facility.
Plan for This Morning .... Decreases the time and cost of development .... Time
zone.
Pharmacy and Pharmaceutical Sciences
Parkville campus, Melbourne
Plan for This Morning Welcome and Introduction
Dr Rocco Iannello
MIPS and Discovery Research
Prof Bill Charman
Translational Medicinal Chemistry Prof Jonathan Baell
CDCO and Lead Optimisation
Prof Susan Charman
SYN|medchem
Prof Andrew Wilks
A virtual opening of the Australian Translational Medicinal Chemistry Facility
Faculty of Pharmacy and Pharmaceutical Sciences Australia’s leading program in Pharmacy Education and Research
Education Programs (approx 1,400 undergraduate students) Under-graduate programs: (i) B Pharmacy, (ii) B Pharmaceutical Science Post-graduate programs: Professional pharmacy/Clinical pharmacy/Healthcare
Research Programs (approx 200 staff, 130 PhD students) Monash Institute of Pharmaceutical Sciences
2010 and 2012 ERA results: 5/5 (well above world standard) Centre for Medicine Use and Safety
2012 QS World University Ranking by Subject
Monash Institute of Pharmaceutical Sciences Established in 2008 as a multi-disciplinary research institute encompassing the key skills in translational aspects of drug discovery, delivery and development
Most successful, experienced discovery/delivery/development scientists in AUS Critical mass: 50 academics; 200 research/professional staff; 130 PhD students MIPS research is aligned to discipline (science) and therapeutic themes
Collaboration | Innovation | Impact
Monash Institute of Pharmaceutical Sciences Basic Collaborating partners/projects
Drug Discovery Biology
Translational
Clinical
Monash Institute of Pharmaceutical Sciences
Medicinal Chemistry
Centre for Drug Candidate Optimisation
Collaborating partners/projects
Drug Delivery, Disposition and Dynamics
Discipline/Science Themes and Therapeutic themes (infectious disease, cancer, neuroscience, pain, inflammation, metabolic disease) Excellent, deep basic research … aligned to support major translational research
Medicinal Chemistry
Drug Discovery Biology
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Medicinal Chemistry
Drug Discovery Biology
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Medicinal Chemistry
Drug Discovery Biology
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Medicinal Chemistry
Drug Discovery Biology
17
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Medicinal Chemistry
Drug Discovery Biology
17
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
The Capability Gap in Translation Medicinal Chemistry Typically, universities not structured to support translational medicinal chemistry: infrastructure/facilities not available; disciplines not “linked up”, inadequate scale, “applied research” inconsistent with traditional funding models (eg. ARC/NHMRC) MIPS wanted to contribute to bridging this gap – leverage capabilities and capacities to support (i) hit-to-lead, and (ii) lead optimisation programs Opportunities all about partnerships/collaborations … and timing … and funding! Federal Government Education Investment Fund (EIF), SuperScience Initiative (Translating Health Discovery: Pharmaceutical and Preclinical Development) Victorian State Government, Victoria Science Agenda Investment Fund
A Gap Exists in Translation Medicinal Chemistry Capability 4-Way partnership: MIPS/EIF/VSA to enable construction and fit-out of Australian Translational Medicinal Chemistry Facility … and partnership with SYN|medchem EIF ($2.1M); VSA ($1.5M) and MIPS support (~0.5M/yr) has enabled a fully equipped facility to be established … and maintained … and operated Goal: Collaborative support for (i) hit-to-lead, and (ii) lead optimisation programs This Facility is an essential element in the higher-level and broader Virtual Pharma Drug Development Network (VPDDN) being established and advanced by Therapeutic Innovation Australia (www.therapeuticinnovation.com.au)
Plan for This Morning Welcome and Introduction
Dr Rocco Iannello
MIPS and Discovery Research
Prof Bill Charman
Translational Medicinal Chemistry Prof Jonathan Baell
CDCO and Lead Optimisation
Prof Susan Charman
SYN|medchem
Prof Andrew Wilks
A virtual opening of the Australian Translational Medicinal Chemistry Facility
My Background – Training and Experience PhD 1992
University of Melbourne (Peptide-Based Drug Design)
1992-2000
Research Scientist, CSIRO and BRI
2001-2012
Medicinal Chemistry Laboratory Head Walter & Eliza Hall Institute of Medical Research
2012-present
Professor & NHMRC Senior Research Fellow Monash Institute of Pharmaceutical Sciences
Key Skills: H2L and LO med chem (variety of disease areas); HTS library design and chemoinformatics; natural product isolation; peptidomimetics; molecular modeling and rational drug design
My Previous Experience … and Capabilities Oncology: Bcl-2 inhibitors 2nd known dual Bcl-2/Bcl-xL ligand with mechanismbased activity (
