RP-HPLC Method Development and Validation for the Determination ...
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RP-HPLC Method Development and Validation for the Determination ...
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Indian Journal of Novel Drug Delivery 9(1), Jan-Mar, 2017, 38-43
Indian Journal of Novel Drug Delivery
IJNDD An Official Publication of Karnataka Education and Scientific Society
Research Article
RP-HPLC Method Development and Validation for the Determination of Alfuzosin HCl in Bulk and Pharmaceutical Dosage Form UMAY CHEN, SHADIA AFRIN, ANTARA GHOSH, SUJAN BANIK* Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.
ARTICLE DETAILS
ABSTRACT
Article history: Received on 15 February 2017 Modified on 22 March 2017 Accepted on 25 March 2017
The present study was undertaken to develop a simple, rapid, accurate and sensitive reverse phase HPLC method for determination of Alfuzosin HCl in bulk powder and pharmaceutical dosage form. The chromatographic separation was accomplished on Hypersill ODS (250×4.6mm, 5μm) column using a mobile phase methanol: water is 90:10 (v/v) at a column temperature of 25°C. The eluents were monitored at 244 nm and total run time was 5 min with a flow rate of 1 ml/min. The drug was well resolved on the stationary phase and the retention time was found as 1.3±0.89 min with injection volume of 20µl.The method was found to be linear at concentration ranges of 10-50μg/ml with correlation coefficient of 0.999. The method was validated for linearity, precision, robustness and accuracy as per ICH guidelines. The results of all the validation parameters were well within their acceptance values (%RSD
