Signal sequence * * * φ * * φ

Signal sequence OGN1_S.aurata OGN1_O.niloticus OGN1_G.morhua OGN1_D.rerio OGN2_S.aurata OGN2_O.niloticus OGN2_G.morhua OGN2_D.rerio OGN_L.oculatus OGN_L.chalumnae OGN_X.tropicalis OGN_G.gallus OGN_H.sapiens

* * *

φ

:----MKSLLFTCMLVP-WLAAASARKSDQ-------DSQLIVGSLPGRELNGYFS---DP--LNSRR-----ARRAVS-LADEPDDS--PVSEGG-DASDLPTCLLCVCLTGSVY :MLDSMKTLFFTCMLVP-WLVAASDRT---------------------KYLDG----------IKPKS-----EKRALP-PADEPDDN--PITAGA-DAADLPTCLLCVCLTGSVY :----MTTVVFLCLLVP-WLATVSGNS-----------------------LDQ---------------------KTQLI-LGRVPAGTELDYLES--RKTKLPTCLLCVCLTGSVY :MRTRLRMLIAAVVLVS-MVLSASGAHYHT----------HRHHRLEDVALTEETD---VRAQRNKRSTNGDDDKNALM-LADAPDDSG-PLQPVG-DPSDLPTCLLCVCLTGSVY :-MMQLRTLIFTYVILP-WILSSAAKD---------------------EFMEA----------RKPKPGVVT--YPDY----EEPATD--AAGDP--KADELPTCLLCVCLSGSVY :-MIPLRILIFTYVMLP-WIVSSAAKG---------------------EYMEA----------RTPAKATVR--ASDYG-ILQDTDTD--GGVPS--KAEVLPTCLLCVCLSGSVY :--MHLEMLICVILIIPSLVLCSPAKN---------------------GYIEA----------RAPKKDIVTIPEFPQD-LPAKPEAAGNMFSTKL-YNSVLPTCLLCVCLIGSVY :-MLDLYATLFTILTHQ-WLLLSCKCS---------------------PVLS-----------KIPKKVILS---QDYD-NPADKDVE--IPGADP-KDDELPTCLMCVCLTGSVY :-MSKLKPLIFSLILVL-WVILAAVTAFTLDS---------EHHNNEKDIFRTPDD---FLTALEAKKQETIIDYEDLPPADTEPAENEVPVLPTPKEAAELPTCLLCVCLSGSVY :---MLHPVLLLFMLVA-WVKAQPVDKDYFTVENVNLDLFDENETGLETTHDVVIYGDYEGKEEPSTRKKESTTPDTFLELLRPPRSPTIEPERVLTQDVDLPTCLLCVCLTGSVY :-MQPLPVCCTLLLLLP-FILSAPSVPQQT-------ISHHEDYIVEGKLFQLNLQ---KMAQTTERNGLTLLSKDRFK-RDQERAGSN-RTAAKV-EDADLPTCLLCVCLSGSVY :-MKTLQAAFFLVAFVP-LVKPAPPIQQDSPKFYEYVDADFATGSLIQQDYE--ML---PKDTIKDGTNVSL--DTALR-LQADDSEL--SARPTK-DTN-LPTCLLCVCLSGSVY :-MKTLQSTLLLLLLVP-LIKPAPPTQQDSRIIYDYGTDNFEES-IFSQDYEDKYL---DGKNIKEKETVIIPNEKSLQ-LQKDEAIT--PLPPKK-ENDEMPTCLLCVCLSGSVY L-motif 1

L-motif 2

L-motif 3

L-motif 4

: 89 : 74 : 63 : 98 : 72 : 75 : 80 : 74 :101 :111 :100 :101 :105

L-motif 5

* OGN1_S.aurata OGN1_O.niloticus OGN1_G.morhua OGN1_D.rerio OGN2_S.aurata OGN2_O.niloticus OGN2_G.morhua OGN2_D.rerio OGN_L.oculatus OGN_L.chalumnae OGN_X.tropicalis OGN_G.gallus OGN_H.sapiens

:CEEVSPDMTSVPTLPKETAYLYARFNKIKKISTKDFAGILTLKRIDLTGNLISEIEDGAFSKLALLESLSLAENRLVKLPMLPAKLTSFNANNNFLKTRGVKANAFKKLTKLTHL :CEEVSPDMTSIPTLPKETAYLYARFNKIRKIKTKDFAEIVTLKRIDLTGNLISEIEDGAFSKLTLLEELSLAENQLVKLPALPAKLTSFNANYNKLKTKGVKANAFKKLTKLANL :CEEVSPDMTSVPALPKETAYLYARYNRIKKIRSKDFADILTLKRIDLTGNLISEVEDGAFSKLPVLEELNLSENRLVKLPMLPAKLTVFNANYNLLKTRGVKATAFKKLTRLVNL :CEEVDPDMTSVPTLPKETNYLYARYNKIKKITAKDFGDIVTLKRIDFTGNIISEIEDGAFAKLTMLEELSLAENQLAKLPMLPAKLTAFNANHNKLKTKGVKANAFKKLNKLLHL :CEEVSPEMSAVPALPKETAYLYARFNKITRIRNSDFADMAPLRRIDLSGNLISEIEDGAFSKLPDLEELILAENKLTRLPIMPTKLVTFNANFNKLKTQGVKATAFKKLTRLSYL :CEDVSPDMSAVPTLPKETAYLYARFNKITKIHREDFADTATLRRIDLSGNLISEIEDGSFSKLPNLEELKLAENRLTKLPMLPSKLVTFNANFNRLKTQGVKANAFKKLTRLAYL :CEEVFPQMTAIPALPRETTYLYARFNQINKIKNKDFADMGALKRIDLTGNIISEIEDGAFSKLTNLEELFLAENRLTKLPMLPSKLTTLNANFNLLKSKGVRSNAFKKLPELAFL :CEDVSPDMTTVPALPQETAYLYARFNKITKITNKDFANIATLKRIDLSGNLISEIEDGAFSKLSHLEELTLAGNKLVKLPMLPANLLSLDVNHNLLKTKGVKANIFKKLIKLAYL :CEEVVPVITAVPALPKETAYLYARYNKIAKIAQKDFSEIPTLRRIDLTGNAISEIEEGAFSKLPQLEELSLAENRLVKLPTLPTKLTLFNANHNRLRTRGVKANAFRKLVNLSYL :CEET--TIDSIPALPQETAYLYARFNKIKSIKTKDFADIPTLKVIDLTGNLIEEIEDGAFSKLLLLEALLLAENRLTRIPALPPKLQLFNANNNRIKNKGIKANAFKKLNNLSYL :CEET--EIEEVPPLPKETAYLYARFNKIKKITAKDFSDFPTLRRIDLTGNLIEEIDDKAFDKLPLLEQLNLAENKITRIPALPTKLTVFNANDNQIKSKGIKANAFKKLTSLAYL :CEEI--DIEAVPPLPKETAYLYARFNKIKRIAVSDFADITTLRRIDFSGNMIEEIEDGAFSKLLLLEELSLAENRLVKLPVLPPKLTTFNANQNRIKSRGIKNNAFKKLTNLAYL :CEEV--DIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFL L-motif 7

L-motif 6

* OGN1_S.aurata OGN1_O.niloticus OGN1_G.morhua OGN1_D.rerio OGN2_S.aurata OGN2_O.niloticus OGN2_G.morhua OGN2_D.rerio OGN_L.oculatus OGN_L.chalumnae OGN_X.tropicalis OGN_G.gallus OGN_H.sapiens

*

φ

:YLADNQLEAVP-QIPDSVQILHLQNNNITEVNVDTFCRSNDT-YLRPSLNEVRLDGNPVVLSKNPDSFTCMKVLPSGRYR:FLADNMLEAVP-YIPESVRILHLQNNNITEVNVDTFCRSNDTYYLRPSLNEVRLDGNPVVLSKYPDNFTCMKVLPVGKYR:FLADNQLEAVP-QIPESVRTLHLQNNNITEISVDTFCKGNNTYYLRPSLNEVRLDGNPVVLSKYPDSFICLRSLPLGRYY:YLAHNELEAVP-LIPETVRTLHLQNNNISTVSTDTFCKSNDTYYIRPNMNEIRMDGNPINLGQYPNSFICLQSLPIGRYQ:YLGNNELTAVP-QLPESLNVVHLQNNKISTITDETFCKGNTSYYIRTNLYQVRLDGNPIQLSKHPNSFICLETLPIGWYN:YLGDNELTAVP-HLPESLYVVHLHNNNISTITDETFCKGNTSHYIRTNMYEVRLDGNPLKLSEHPNSFICLQSLPIGWYK:YLGNNKLEVIP-QLPESLQIVHLNNNNINTITDQTFCKGNTTQYIRSTMEEVRLDGNPLVLAQHPNSFICLRNLPTGHYH:YLGDNGLEAIP-PLPESLRVVHLHNNNITSLTDDTFCKGNSTHYIRHNMQEVRLDGNPITLAQHPNSFICLRALPIGHYK:YLANNELEAVPPHLPESLRVLHLQNNNITAITDETFCKGNNTRYIRTNMDEIRLEGNPIILGKYPNSFTCLKSLPMGSYF:YLTHNVLEKVPPQIPDTLRVLHLQFNNITSITDDTFCKANDTSYIRDCMDEIRMEGNPIILAKFPNSFICLKMLPFGRYY:YLANNQLESVPQNLPESLRILHLQQNGISSITDDTFCKSNDTHYVRSHMDEIRMEGNPVILGKYPNSFTCLKTLPSGSYFK :YLGHNALESVPLNLPESLRILHLQHNNITTINDDTFCKSNNTRYIRTRMDEIRMEGNPILLAKHVNAFSCLRTLPVGTYY:YLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPIVLGKHPNSFICLKRLPIGSYF-

:282 :268 :257 :292 :266 :269 :274 :268 :296 :304 :294 :294 :298

:204 :189 :178 :213 :187 :190 :195 :189 :216 :224 :213 :214 :218