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Accepted Manuscript Subcortical mapping using an electrified CUSA in pediatric supratentorial surgery Jonathan Roth, MD, Akiva Korn, MMSc, D-ABNM, Yifat Bitan-Talmor, MMSc., Rivka Kaufman, MSc., Margaret Ekstein, MD, Shlomi Constantini, MD, MSc PII:

S1878-8750(17)30185-7

DOI:

10.1016/j.wneu.2017.02.023

Reference:

WNEU 5254

To appear in:

World Neurosurgery

Received Date: 5 January 2017 Accepted Date: 6 February 2017

Please cite this article as: Roth J, Korn A, Bitan-Talmor Y, Kaufman R, Ekstein M, Constantini S, Subcortical mapping using an electrified CUSA in pediatric supratentorial surgery, World Neurosurgery (2017), doi: 10.1016/j.wneu.2017.02.023. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT Roth Subcortical mapping using an electrified CUSA in pediatric supratentorial surgery

Shlomi Constantini2

RI PT

Jonathan Roth*2, Akiva Korn*1, Yifat Bitan-Talmor1, Rivka Kaufman1, Margaret Ekstein3,

Intraoperative Neurophysiological Monitoring Service1 Dana Children’s Hospital

M AN U

Tel-Aviv Medical Center Tel-Aviv University

Jonathan Roth, MD

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* Both authors (JR, AK) have equally contributed.

Corresponding author:

EP

Department of Pediatric Neurosurgery

Dana Children's Hospital, Tel-Aviv Medical Center

AC C

6 Weizman Street

SC

Departments of Pediatric Neurosurgery2, Anesthesiology and Critical Care3, and the

Tel Aviv, 64239 Israel

Tel Office: 972-3-697-4686 Fax: 972-3-697-3451

Cell: 972-524-2620-95 [email protected]

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ACCEPTED MANUSCRIPT Roth Jonathan Roth, MD, Akiva Korn, MMSc., D-ABNM, Yifat Bitan-Talmor, MMSc., Rivka Kaufman, MSc., Margaret Ekstein, MD, Shlomi Constantini, MD, MSc

RI PT

Keywords: CUSA, mapping, monitoring, pediatric, tumor resection, subcortical stimulation

Abbreviation list:

SC

APB - Abductor Pollicis Brevis

CUSA – Cavitron UltraSonic Aspirator CST – corticospinal tract

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AVM – arteriovenous malformation

dcMEP – direct cortical motor evoked potentials GTR – gross total resection

TE D

MEP – motor evoked potentials MRI – magnetic resonance imaging STR – subtotal resection

AC C

EP

tcMEP – transcortical motor evoked potentials

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ACCEPTED MANUSCRIPT Roth Abstract

Background

RI PT

Intraoperative electrophysiology is increasingly used for various lesion resections, both in adult and pediatric brain surgery. Subcortical mapping is often used in adult surgery when lesions lie in proximity to the corticospinal tract (CST). We describe a novel technique of

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continuous subcortical mapping using an electrified Cavitron UltraSonic Aspirator (CUSA) in

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children with supratentorial lesions.

Methods

We evaluated the method of subcortical mapping using a CUSA as a stimulation probe. Included in this study were children (

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