Line Scan Diffusion Imaging of the Spine - Semantic Scholar
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Line Scan Diffusion Imaging of the Spine - Semantic Scholar
with benign vertebral compression fractures was performed to assess the potential of line scan diffusion imaging of the spinal column. In a subgroup of six ...
AJNR Am J Neuroradiol 24:5–12, January 2003
Line Scan Diffusion Imaging of the Spine Roland Bammer, Andreas M. Herneth, Stephan E. Maier, Kim Butts, Rupert W. Prokesch, Huy M. Do, Scott W. Atlas, and Michael E. Moseley
BACKGROUND AND PURPOSE: Recent findings suggest that diffusion-weighted imaging might be an important adjunct to the diagnostic workup of disease processes in the spine, but physiological motion and the challenging magnetic environment make it difficult to perform reliable quantitative diffusion measurements. Multi-section line scan diffusion imaging of the spine was implemented and evaluated to provide quantitative diffusion measurements of vertebral bodies and intervertebral disks. METHODS: Line scan diffusion imaging of 12 healthy study participants and three patients with benign vertebral compression fractures was performed to assess the potential of line scan diffusion imaging of the spinal column. In a subgroup of six participants, multiple b-value (5–3005 s/mm2) images were obtained to test for multi-exponential signal decay. RESULTS: All images were diagnostic and of high quality. Mean diffusion values were (230 ⴞ 83) ⴛ 10ⴚ6 mm2/s in the vertebral bodies, (1645 ⴞ 213) ⴛ 10ⴚ6 mm2/s in the nuclei pulposi, (837 ⴞ 318) ⴛ 10ⴚ6 mm2/s in the annuli fibrosi and ranged from 1019 ⴛ 10ⴚ6 mm2/s to 1972 ⴛ 10ⴚ6 mm2/s in benign compression fractures. The mean relative intra-participant variation of mean diffusivity among different vertebral segments (T10 –L5) was 2.97%, whereas the relative difference in mean diffusivity among participants was 7.41% (P < .0001). The estimated measurement precision was
