MULTIPLE SEQUENCE ALIGNMENT File - PLOS

CLUSTAL X (1.81.1-alpha) MULTIPLE SEQUENCE ALIGNMENT File: /Users/saierlab/Desktop/69BBcut.ps Date: Tue May 12 18:56:54 2009 Page 1 of 6 Mba1 Psp2 Ybe1 Ype5 Eco14 Sen3 Ymo1 Yen2 Pas1 Yfr1 Yfr5 Yps7 Yfr2 Yfr3 Yps4 Yps2 Esa2 Plu1 Eco1 Pru1 Pal3 Eta1 Sgl1 Eco26 Pmi1 Efe5 Eco20 Eco25 Eco15 Eco6 Efe2 Efe3 Pal2 Csu1 Eco3 Cko1 Sen1 Eca1 Esp2 Esa3 Kpn1 Pan1 Eta2 Spr1 Yin1 Yin2 Yfr4 Ymo2 Eco10 Eal1 Sty4 Eco16 Ahy1 Sen2 Efe4 Bpe1 Bav2 Bbr1 Bpa2 Bav1 Pma1 Pma3 Pma5 Pma4 Ssp1 Ssp2 Plu2 Cla1 Rba1 ruler

---------------------------------FGAQGGSKP-----------------------SGGLLVVAPLSDPDD ---------------------------------LSTGVTNEV-----------------------TGSVLVVKPISDPSD --------------------------------WLNNFGTARLQANVDDRG------------DLDGSQFDMLMPFYDTPS --------------------------------WFNQFGSAKVQLNLDEKL------------SLKGSQLDVLLPLTDSPD --------------------------------WLNQFGTAKTQLSVVSDF------------SLKGSSLDVLLPFYNTPK --------------------------------WLQQFGTAKVNLGLDKDL------------SLDNASLDLLLPLYDDKK --------------------------------WLGHIGKAQVKLQVDDKN------------DFSGSELHLFVPLYNQPE --------------------------------WLGHIGQAQVKLQTDDKN------------DFSGSEIDLFIPLYDQPE -------------------NDDVMQGSDISKSGIADMGFAALQPETEKSAGEVRANLPLSDGKLTSGSIDLFYPLYDGDS --------------------------------WLGQYGNARVQLNSNS-----------------IGNADVLIPLTETQ--------------------------------WLSQFGHARVQLNSSG-----------------TGNADILLPLVESQ--------------------------------WLSQFGTARVQLNINDDF------------HLDGSAADVLIPLYDNE--------------------------------WLSQFGTARVQMNVNDDF------------KLDGSAVDVLVPIYDNQ--------------------------------WLSQFGTARVQLNLDNNL------------SLKGSAFDMLLPLYDDQ--------------------------------WLNQFGTARVQLNVDSDF------------KLDNSALDLLVPLKDSE--------------------------------WLNRFGTAQVNLNFDKNF------------SLKESSLDWLAPWYDSA--------------------------------WLSHFGTAQVTLDVDDNG------------NWDNSAFDFLAPLYDNK--------------------------------WLSQFGTAKINLNVDHRG------------RLDESSVDLLVPFYDDKD --------------------------------WLQHYGTAEVNLQSGNN--------------FDGSSLDFLLPFYDSE--------------------------------WFNRFGSSQIHLEADKKF------------SLKNSQIDLLMPWYETE--------------------------------WFNHFGSSQIKLEADKKF------------SLKNSQIDLLLPLYETE--------------------------------WLNQFGTARVQLDADEHF------------SFKNSQFDLLAPLYEQK--------------------------------WLSQFGTARLQLDVDNKF------------SLKNSQLDLLIPLYEQP--------------------------------WFENFGTAHIQLQVDKNF------------SLKNSQLELLFPVFEDD--------------------------------WLNQFGHARVSLSADKNL------------TLKNSSAELLIPLYEQK--------------------------------WLQQYGNARIKLNVDDSF------------SLKDAEFDFLYPWMDTK--------------------------------WLGKYGTARVKLNVDKDF------------SLKDSSLEMLYPIYDTP--------------------------------WLSRFGTARITLGVDEDF------------SLKNSQFDFLHPWYETP--------------------------------WLNNFGTAXISLGVDEDF------------SLKNSQFDFLHPWYDTP--------------------------------WLSRWGTARVSLGVDEDF------------SLKSSSFEFLHPWYETP--------------------------------WLSQWGTARVTLSADEHF------------TLKGSALDLLLPWYDTP--------------------------------WLSQWGTVRVTLGLDEDF------------TLKGSAFDLLLPWHDTP--------------------------------WLSKAGNVKLNIDFDKKF------------SIKNSQFDWLIPWYDQE---------------------------------------LRFDFFPGDRE-----------YPFERTAIDWLFPFYDSL--------------------------------WLSPWGNASVDVKVDNEG------------HFTGSRGSWFVPLQDND--------------------------------WLSPWGNASVDLRIDNEG------------SFTGSRGGWFIPWQDNT--------------------------------WLSAWGSASVDVKVDNEG------------HFNGSRGSWFIPLQDKQ--------------------------------WLSPWGNASVNVRVDDNG------------TFNGSSGSWFIPWNDNN--------------------------------WLSPWGNASVDLLVDEEG------------KFNGSSGRWFIPWQDNN--------------------------------LLSPWGNATVDLLVDEEG------------NFNGSSGSLFTPWQDNN--------------------------------WLSPWGNANVDLLVDKEG------------KFTGSKGSWFVPLQDND--------------------------------LLSPYGNAEFNLNVDMAG------------NFDGTGGNLFSPLADEN--------------------------------LLSPYGRASVSLALSDDG------------SFNGTSAQLLTPWQDNY--------------------------------LLSPLGNAKLSLVMSDQG------------DFSGSSGQLFSPLYDVN--------------------------------LLGKFGKAQVNLAVDDKG------------SLSKSSFSLFSPWYEND--------------------------------LLGKFGKAQVNLAVDDNG------------SLSKSAFSLFSPWYEND--------------------------------LLGKFGQAQVSIAVDDHG------------DFSKSTFSLFTPWYEND--------------------------------LLGRFGQAQVNLSMDNKG------------NLNRSTASLFTPWYDSE--------------------------------TLSPYGKVRSNLSIGQGG------------DLDGSSIDYFVPWYDNQ--------------------------------ALSPYGKVRSNLSIGQGG------------DLEGSSIDYFIPWYDDQ---------------------------------MSPYGKIRTSLSVGEGG------------DLDGSSLDYFVPWYDNE--------------------------------VLSPYGSVRTSLSIGEGG------------DLDGSTFDYFVPWYDNQSASRYGSEQEVQYWRQQLATQFEEEANAYAASLLGAMGTARTRVTLDDDF------------NMVTAEADLLLPLAEEQ-------------------------------------IIFRGGVNLEDGA------------KYRSSEFDMFIPVQETT-------------------------------------AQFRGGITLEDAS------------KYRSAEADLLIPLYQST--------------------------------GLPFLRNLQGGLSHDFES------------GRTSLQLNTIDEVYRAG--------------------------------GLRFLRNLQGDLRHDFDN------------GRTSLELRTIDQVYRKG--------------------------------ELPFLRRLQGGVNYDFSN------------KDLSLDLRTIDEVHRGE--------------------------------GLPWLRRLEGNVSYDFSG------------RDVAVDVRTIDALHLDQ--------------------------------GLPWLRHLDGGLRYDLDP------------GRLSFSLRTIDDLMVSE---------------------------------AQTSVNISGGTESDTSF------------SINSLMKLGELAKDDQGD ---------------------------------AQTNFNISGGSESDTSF------------SINSLMKLGELAKDEEGD ---------------------------------AQTSLNIGGGTESDTSF------------SLNSLMKLGELAKDDEGD ---------------------------------AQTTVSINGTSNSETSF------------SLDSLMKLREMATDDEGD ---------------------------------AQTTLGLDAATSSDLTG------------YLDSFMRLKTIGYDNEGD ---------------------------------SQTEFGVGFESDADMTY------------YLNSLISLAQLGSDDNGY ----------------------------------TNAPS-----------------------WVTSWDVTVPCPVYVSEN ---------SKSKEEIVKNMASSYLNTSANELAKEFIDSLNTSINTDFSFN-------YNERSGFSGNAKALLPIVSEDN ----------------------------------LSVGSDTMGLDKNKSD--------------TKTEAMTVYRLKETG1.......10........20........30........40........50........60........70........80

24 24 36 36 36 36 36 36 61 30 30 35 35 35 35 35 35 36 33 35 35 35 35 35 35 35 35 35 35 35 35 35 35 29 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35 34 35 67 30 30 35 35 35 35 35 35 35 35 35 35 35 23 64 31


. . * * * . . * . * * IFNTYFTQGSVFY----EDN-RTTLNLGLGYRK------LSDNKMLLTGINAFYDHEFP---YDHGRTSIGLEARTTVWE NENIIFTQASLFL----SDDSRETINLGFGNRK------LINDDTLLVGYNLFYDHELD---YDHQRASIGIEAISSVGS --QMAFTQFGIRR-----IDKRTTANLGIGIR-------HFIDD-WMVGYNLFLDRDIT---RDHTRVGAGAEYARDYLK --LLTFTQLGGRY-----IDDRVTLNVGLGQR-------HFFAQ-QMLGYNLFIDHDAS---YSHTRIGVGAEYGRDFIN --NVLFTQLGMRD-----NDGRFTTNAGLGHR-------YFTDNGWMLGYNVFYDVDWR---NTNRRYGIGVEAWRDYLK -QNLLFTQWGGRR-----DDDRNIINVGMGYR-------YFADR-WMWGINTFYDRQISD--NAHERLGIGGELGWNYFK --RLAFSQFGFRR-----IDQRNIMNIGLGQR-------HYLSD-WMLGYNVFLDQQISG--NAHRRLGLGGELARDYVK --KLAFSQFGFRR-----IDQRNIMNIGLGQR-------HYVSD-WMFGYNIFFDQQVSG--NAHRRVGFGGELARDYIK --RLFFGQVGARR-----FDGRNIVNLGIGQR-------YFQGD-WALGYNTFYDIQISG--NAHQRLGFGLEYWRDYLY -NNLLFGQLGVRY-----NGERTTNNVGLGVR-------SFTDS-WMFGVNTFYDYDLT---GKNSRLGVGGEAWTDNLK -DNLLFGQLGVRY-----DGYRTTNNAGIGVR-------QFTEN-WMFGVNSFYDYDLT---GKNSRVGVGAEAWTDNLK -KSILFTQLGARN-----KDSRNTVNMGAGVR-------TFQGN-WMYGANTFFDNDLT---GKNRRIGVGAEAWTDYLK -KSILFTQLGARN-----KDNRNTVNIGAGVR-------TFQNN-WMYGVNTFFDNDMT---GKNRRVGVGAEAWTDYLK -KSLLFSQFGLRN-----HDSRNTINIGAGVR-------TLQDN-WMYGANVFFDRDIT---GKNNRIGFGAEAWTDYLK -SSLLFTQLGVRN-----KDSRNTVNIGAGIR-------QYQGD-WMYGANTFFDNDLT---GKNRRVGVGAEVATDYLK -SFLFFSQLGIRN-----KDSRNTLNLGVGIR-------TLENG-WLYGLNTFYDNDLT---GHNHRIGLGAEAWTDYLQ -KSVLFTQLGIRA-----PDGRTTGNIGLGVRT------FYVRD-WMFGGNVFFDDDFT---GENRRIGFGAEAWTNYLK -HWLVYSQYGYRH-----KDSRDTVNLGIGTR-------LFINN-WMYGANTFYDNDLT---GNNSRFSLGGELWTNYLK -KMLAFGQVGARY-----IDSRFTANLGAGQR-------FFLPE-NMLGYNVFIDQDFS---GDNTRLGIGGEYWRDYFK -DNLIFSQTSLHR-----KEGRIETNLGLGAR-------WYGE-GQMIGGNTFFDYDIS---RKHSRLGLGVEYRRDFLK -NNLLFTQTSLHR-----KEGRIETNLGLGTR-------WYGE-NQMIGGNSFFDYDIS---RKHSRLGLGVEYRRDFLK -DSLIFTQGSLHR-----TDDRTQVNLGFGLR-------YFAP-SYMLGGNIFGDYDLS---RAHSRTGIGMEYWRDFLK -DKLVFTQGSLHR-----TDDRTQTNLGMGMR-------WFND-GYMLGGNTFLDYDLS---RDHARMGMGVEYWRDYLK -ERLFFSQGGISY-----IDDKFISNIGIGYR-------AFYD-NWMLGGNSFIDYDLR---KEHSRLGLGIEYWQDNLK -EKLIFAQTNYHR-----KDLRSQFNYGIGYR-------YFTE-KFMVGINGFYDHDLT---HHHNRLGIGAEIWRDYFK -DYVLFSQTSLHR-----TDDRNQANIGIGVR-------HFTPDNAMLGANIFYDYDLT---RSHSRAGFGVEYWRDYLR -TNMLFTQGAIHR-----TDDRTQSNIGFGWR-------HFSGNDWMAGVNTFIDHDLS---RSHTRIGVGAEYWRDYLK -DNLFFSQHTLHR-----TDERTQINNGLGWR-------HFTP-TWMSGINFFFDHDLS---RYHSRAGIGAEYWRDYLK -DYLLFSQHTLHR-----TDDRTQINTGLGWR-------HFTS-SWMSGINLFFDHDLS---RYHSRAGLGAEYWRDYLK -DNLVFSQHTLHR-----TDDRTQTNHGIGWR-------YFTS-SWMSGVNMFIDHDLT---RYHTRTGMGVEYWRDYLK -ENIIFTQHSIHR-----TDDRNQLNTGTGWR-------HFMP-DYMTGVNLFFDHDLT---RYHSRMGLGGEYWRDNLK -ENLLFTQHSFHR-----TDDRNQLNTGAGWR-------HFAP-DYMAGVNLFFDHDLT---RYHSRMGLGGEYWRDNLK -DILLFTQHTLHR-----YDERFHTNNGIGLR-------YFHE-KSTIGMNAFIDHDLS---HAHTRVGLGVEYWQDYLK -EFLFFSQLGFRHN----LDRRDIINLGGGGR--------FFRKNWMLGANAFCDCDLT---GTNTRLGLGLESWTNFLQ -RYLTWSQLGLTQ-----QDDGLVSNVGVGQRW------ARG--NWLVGYNTFYDNLLD---ENLQRAGFGAEAWGEYLR -RYLTWSQLGLTQ-----QDDGLVSNVGIGQRW------ARD--GWLLGYNTFYDNLLD---ENLQRAGFGAEAWGEYLR -RYLTWSLLGLTQ-----QTDGLVSNIGVGQRW------VQN--GWLLGYNTFYDNLLD---ENLQRAGVGAEAWGEYLR -RYLSWSQLGLTQ-----QTDGLVSNAGVGQRW------VAG--NWLLGYNTFYDNLLD---ENLQRAGLGAEAWGQNLR -RYLSWSQLGLTQ-----QTDGLVSNAGIGQRW------VAG--KWLLGYNTFYDNLLD---ENLQRAGLGAEAWGENLR -RYLTWSQVGVSQ-----QNQGLVGNAGIGQRW------AAG--HWLLGYNTFYDRLFD---DDTSRAGFGAEAWGDYLR -RYLTWNQYSVTR-----REHDLVGNIGLGQRW------RVG--GWLLGYNSFYDKVLS---ESLARGSVGAEAWGEYLR -RYLTFSQLGLHD-----SVEGVVGNAGLGQRW------DAG--NWLLGYNSFIDRSFR---TGLQRASVGTEAWSNNLR -QYLTFSQLGIEQ-----SEYGTVGNAGLGQRW------IAG--SWRVGYNAFVDGLLG---SDRQRGSLGAEAWGEYLR -GLLTYSQLGLLQ-----QTEGSLGNFGLGQRW------VAG--DWLLGYNTVLDSDFE---RHHNRASLGAEAWGDFLR -AMVAFSQVGIHG-----QDGRMIGNLGAGVRF------DQG--DWLLGANTFFDQDIS---RNHSRLGLGLEWWADNLK -AMVAFSQVGVHR-----QDNRMIGNLGAGVRF------DQG--DWLFGANTFLDQDIS---RNHSRLGLGLEWWADNLK -AMVAFSQVGIHD-----QDSRTIGNFGAGLRW------DKG--NWLLGYNTFLDQDFS---RNHSRLGLGAELWTESLR -QYLLFSQINIHH-----QDNRKIGNFGLGHRI------ELPSLNGLLGYNVFIDHDFS---RGHNRAGIGAEARADYLK -TTVYFSQFSAQR-----KEDRTIGNIGLGVRY------NFD--KYLLGGNIFYDYDFT---RGHRRLGLGAEAWTDYLK -STVYFSQFSAQR-----KEERTIGNAGIGVRH------NFD--KWLLGGNIFYDYDFT---RGHRRLGLGTEAWTDYLK -KTLLFSQLSAQR-----KEDRTIGNFGLGVRQ------NVG--NWLLGGNAFYDYDFT---RGHRRLGLGTEAWTDYLK -ETLVFSQFSAQR-----KDDRTIGNIGVGVRQ------NIG--SWLLGGNLFYDYDFT---RGHRRLGLGSEAWTDYLK -QTLLFTQFGLRRN----GQDRTIANLGVGQRH------FLDR--WMLGYNLFADYDLT---NRHWRAGVGAEAWRDYLK -SSLLFGQLGFRDHDSSSFDGRTFANVGMGYRQ------EVNG--WLLGVNTFLDADIR---YSHLRGGIGGEVYKESLA -SSILFGQLGLRDHDNNSFNGRFFVNTGIGWRQ------DVGD--WLLGINSFLDADVR---YDHLRGSLGVELFRDSMS -RNTGLLQLGAHN-----QNDRPTANAGAVYR-------REVNDALMVGANGFLDYEFG---KQHLRGSVGLEVIAPEFS -ANTGLLQLGGHN-----QNNRPTANLGGVYR-------RDINERLMLGANAFLDYEFA---KQHLRGSLGVEAIAPEFS -RDRVLLQLSGHN-----RNHRPTVNGGVVLR-------HALNQHMAVGANAFLDYEFG---KNHLRGSLGGEVIAPQFT -DRALLLQLGGHN-----QNHRPTVNAGVVAR-------SAAGSSLILGGNAFLDYEVG---KRHLRGSLGAEAVAAQFT -RRALMLQAGLHN-----QNQRPTANTGIVLR-------QQASPGLIVGSNAFLDYEFG---KQHVRGSLGLEAIAPHYS LKTLAFSQARFATAT---NAEGSTINIGLGIR-------NRPDDISMVGANAFWDYRMTDYSDAHSRLGLGGEYFWKDFE LKTLAFSQARFATAT---NADGSTFNLGLGIR-------NRPNDISMVGANAFWDYRMTDYSDAHSRLGLGGEYFWKDFE IKTLAFSQARLATAT---NAEGSTTNLGLGIR-------HRPNDVSMLGANAFWDYRMTDYSDAHSRLGLGGEYLWKDFE IKTLLFSQAKLSKTS---NSDGTTANLGLGIR-------HRPNNESMMGANAFLDYRMTDYSDSHSRLGLGGEYLKNGWE PMGLMFGQARVTLET---SAQ-PQVNVGLGSR-------FRLGDEAIVGLNGFWDLRTTNYSTAYTRWGIGAEGFWKSFE PLGLLFAQG-SAKGA---YSGSAVTNLGLGLR-------RRLRDNAMLGANAFWDYRFTNYSSSYSRWGAGAELWWDDFK QADNIFFEGGFDY-----QDARKTVDGALGYRH------LMSDNKVMLGANVLYSHEFP---RNHQRISYGAEIRTSVFE PKISYFLQSGIGEF----ANDRTIGHFGGGIRYYPNATALNNSGNIMLGLNSVYDHDFS---RGHKRMSLGAEAMVDTLA -NWFLFNQTSAVN-----FNNRTTINTGFGARH------INDANTVITGYNIFYDYELQ---SKHERVGAGLELLSSIFE ........90.......100.......110.......120.......130.......140.......150.......160

90 91 98 98 99 100 99 99 124 93 93 98 98 98 98 98 99 99 96 98 98 98 98 98 98 99 99 98 98 98 98 98 98 93 98 98 98 98 98 98 98 98 98 98 98 98 98 100 98 98 97 98 131 98 98 99 99 99 99 99 105 105 105 105 104 104 89 137 96


* * * * INANKYWATTKWKTGK-----NGLE--------------------ERALDGYDIEAGVPLPYMNWATVFVKNFQWDSEIS LRANQYYGLSGWKSGL-----NNIN--------------------EKALNGSDVELGMPLPYLPWTNLYYRSFNWEG-AS LAANGYLRLSDWRDS--PDFS-SYS--------------------ERPATGFDLRAEAYLPSLPQLGGKLMYEQYFGNDV LAANGYFGVSGWKNS--PDLD-KYD--------------------EKVANGFDLRSEAYLPTLPQLGGKLIYEQYFGDEV LSANGYKRLSDWRQS--PTVT-DYD--------------------ERPADGWDIRAEGWLPAYPQLGGKLVYEQYYGNEV LSANGYKRLSGWKDS--SEYE-DYQ--------------------ERVANGYDIRAEGYLPAWPQLGAQLVWEQYYGDDV LSANSYYRLGGWKNS--TRLE-DYD--------------------ERAASGYDIRTEAYLPYYPQLGGKLMYEQYFGNEV LSANSYHRLGGWKNS--TRLE-DYD--------------------ERAANGYDIRTEAYLPHYPQLGGKLMYEQYFGDEV LSANGYFGLTDWYSS--SALD-GYA--------------------ERAANGYDIRAQGWFPVYPQLSGKLKFEQYFGDDI FSANGYFRLTDWHQSVLADME-DYN--------------------ERPANGFDVRAEAYLPSYPQLGGRLMYEKYFGKGV FSANGYFRLTDWHQSVLSDME-DYN--------------------ERPANGFDVRAAAYLPAYPQLGGSLMYEKYFGKGV LSANNYFGITDWHQS--RDFI-DYN--------------------ERPANGYDLRAEAYLPSYPQLGGKAMYEKYRGDDV LSANSYIGTSDWHQS--RDFA-DYN--------------------ERPANGYDVRAEAYLPSHPQLGGKLMYEKYRGEEV LSANSYLRLTDWHQS--RDFA-DYN--------------------ERPANGYDLRVEAYLPAYPQIGTNLKYEQYKGNEV FSANTYFGLTGWHQS--RDFS-SYD--------------------ERPADGFDIRTEAYLPAYPQLGGKLMYEKYRGDEV LAANGYFRLNGWHSS--RDFS-DYK--------------------ERPATGGDLRANAYLPALPQLGGKLMYEQYTGERV LSANTYIGTSQWHNS--GDFD-NYN--------------------EKPADGYDVRAEGYLPSFPQLGAKLMYEQYYGDNV MSANAYFRLSDWHNA--RDLV-NYY--------------------ERPANGYDLIADMYLPSMPSLGAKIKYEQYFGDNV SSVNGYFRMSGWHES--YNKK-DYD--------------------ERPANGFDIRFNGYLPSYPALGARLMYEQYYGDNV LSANSYHRLSGWRSS--RDLA-DHS--------------------ARPSNGWDVRAEGWLPSYPHIGGKLTYEQYYGDSV LSANSYHRLSGWRNS--RDLA-DYS--------------------TRPANGWDLRAEGWLPIYPHIGGKLTYEQFYGEEA LSANGYLRLSDWNNS--SDFK-DYQ--------------------ERPANGWDIRAQAWLPSLPQLGGKLTYEQYYGRGV IGANNYLRLTNWRDS--KDFA-DYQ--------------------ERPANGWDMSLEGWVPALPQLGGNLKYEQYYGKEV LGANSYLRLSNWRNS--SNIV-DYE--------------------ERPANGLDLNIKSWLPSYPQIGGDIKYEKYYGDDV LSSNHYHRLSSWRAS--NNIL-DYS--------------------ERPANGWDIRTEGYFPAYPQLGTKLIFEQYYGKEV FGANTYFGLSDWKNS--RDLA-DYL--------------------ERPANGWDVSAEGWLPAYPQLGASVQFEKYYGKNV LSANGYIRASGWKKS--PDIE-DYQ--------------------ERPANGWDIRAEGYLPAWPQLGASLMYEQYYGDEV LSSNGYLRLTNWRSA--PELDNDYE--------------------ARPANGWDVRAEGWLPAWPHLGGKLVYEQYYGDEV LSSNAYIGLTGWRSA--PELDNDFE--------------------ARPANGWDLRAEGWLPAWPQLGGKLVYEQYYGDEV LSGNGYLRLSNWRSA--PELDNDYE--------------------ARPANGWDLRAEGWLPAWPQLGGKLVYEQYYGDEV LGANGYLRLTGWRDA--PELDYDYE--------------------ARPANGWDVRAEGYLPAYPQLGAKLMYEQYYGDEV LGANGYLRLSGWRDA--PELDYDYE--------------------ARPANGWDVRAEGYLPAYPQLGATLMYEQYYGDEV LNANSYFGLTSWKSA--SELNHDFN--------------------AKPAHGWDIQVEGWLPNYPHLGGNLRYEQYYGDSV FSMNGYLGLSSPRHS---SLQPNYQ--------------------ESPAHGLDFRLHYWLPFFPRLGGKIFYEQYFGKQV LSANFYQPFAAWHEQ----TATQE---------------------QRMARGYDLTARMRMPFYQHLNTSVSVEQYFGDRV LSANYYQPFASWHEQ----TTALE---------------------QRMARGYDVTAQMRMPFYQHLNTSVSVEQYFGERV LSANYYQPFADWQTH----TATLE---------------------QRMARGYDINAQMRLPFYQHINTSVSLEQYFGDSV LSANYYQPFAGWRDD----SDVQE---------------------QRMARGYDVTAKAWLPWFHHLNTSVSFEQYFGDSV LSANYYQPFASWRDS----SDLQE---------------------QRMARGYDVTAKAWLPYFHHLNTSVSFEQYFGDNV LSANYYQPLGGWQHR----AGLLE---------------------QRMARGYDVTAQAYLPFYQHINTSVSFEQYFGDQV LSANYYHPLGDWQLRD---NQTQE---------------------QRMAAGYDVTAQARLPFYQHINTSVSVEQYFGDSV FSANYYHPLSGWRNRG---DSQQ----------------------SRMAEGYDITTQSYLPFYRQLGVSFSYQQYLGEKV LSANYYHPLSGWRNRS---NSSQ----------------------MRMARGYDITTRGYLPFYHQLGVTLSYEQYLGDRI FSANYYYPLSALAQQR---DNAQFL--------------------SRPASGYDITTQGYLPFYRQIGGSLSYEQYWGENV LATNYYHPLSGWKDSK---DFDDYL--------------------ERPARGFDVRAQGYLPAYQQLGASVVYEQYYGDEV LASNYYHPLSGWKDSK---DFDDYL--------------------ERPARGFDVHAQGYLPAYQQLGASAVYEQYYGDEV LATNFYHPLSGWKDSK---DFDDYL--------------------ERPAKGFDVRLQGYLPAYPHLGASVVYEQYYGDEV FSANYYHPLSHWKDSP---DFDDYL--------------------ERPAKGYDLRSQGYLPAYPQLGVSAVYEHYFGDEV FSGNYYHPLSDWKDSE---DFDFYE--------------------ERPARGWDIRAEAWLPAYPQLGGKIVFEQYYGNEV FSGNYYHPLSGWKNSE---DFDFYE--------------------ERPARGWDIRAEAWLPAYPQLGGKIVFEQYYGDEV FSGNYYHPLSDWKDSE---DFDFYE--------------------ERPARGWDIRMESWLPFYPQLGAKLVYEQYYGDEV FSGNYYHPLSDWKDSK---DFDFYE--------------------ERPARGWDVRAEGWLPAWPQFGAKLVYEQYYGDEV LGANFYTPLSSWRDSP---RFEGME--------------------ERAARGMDVRLEAYLPAYPQWSASLTAEQYLGERV FSGNYYFPLTGWRTS---AAHEFHD--------------------ERPAYGFDLRTKGTLPDFPWFSGELTYEQYYGDKV LAGNWYFPLSDWKAS---KVQPLHD--------------------ERPATGIDVRLKGALPSLPWFGAELAFEQYFGDKV LYGNVYAPLSDWKGAK---RNNRRE--------------------EKPASGMDVGVGYRPAFAPGLSLSATHFRWNGAEV FYGNVYAPMSGWTGAK---RDNRRE--------------------ERPASGMDLGMKYSPGFAPGLSLKANYFRWNGAAV LYGNVYAPMSGWKAAK---RAERRE--------------------ERPASGWDVGVRLQPEALPGLAIKGQYFRWSGAAV LYGNVYAPLSGWKAAK---RAERRE--------------------ERPAAGWDVGFTARPEAVQGLALNAQYFRWRGAQV LYANYYAPLSGWKGAR---RDSRRE--------------------ERPAAGYDLGGQLS--SDAGLSLQAAYFRWHGAGI FRNNWYMAITNEKDVIIKGVDYQ----------------------ERVVPGWDLEVGYRLPNNPELAFYIRGFNWDYKYT FRNNWYISITDEKDVTIKGVSYK----------------------ERVVPGWDVELGYRLPNNPELAFFVRGFNWDYKHT LRNNWYMSITNEKDVTIKGVSYK----------------------ERVVPGWDVELGYRLPNNPELAFFVRGFNWDYKNT LRNNWYMSMTEQKNVTVNGTVYT----------------------ERVVPGWDVEAGYRFPNHPEMAVFVKGFNWDYKNT LRNNWYINGSADKNITINNIDYV----------------------ERVVPGWDVEVGYRIPSYPQLAIFVRGFNWDYQDH LTNNWYIAGTGIKRITTSGRAYTDTTSLAAGTYDETTLLGANTFDERVVPGWDVALNYRLPSYPQLSLGIRGFRWDYMRK INSNYYHRLTDWKLTG---VDNNE---------------------EKARGGYDVELALAVPYVPSAHFRVKHFCWNGIAS FNANVYQRLSSWIDSY--DFDKDYVQ-------------------ERPANGWDAKIKYAFPSLINVSFFAKMGQWYGNKV FRANAYQAVSKTLTYN------GIQ--------------------ETALDGYDAKLTANLPYFYSS-------NLYGKLS .......170.......180.......190.......200.......210.......220.......230.......240

145 145 155 155 156 157 156 156 181 152 152 155 155 155 155 155 156 156 153 155 155 155 155 155 155 156 156 156 156 156 156 156 156 150 153 153 153 153 153 153 154 153 153 155 155 155 155 157 155 155 154 155 188 155 155 156 156 156 156 154 163 163 163 163 162 184 145 196 143


GSKD---------IKGNDLQLRAYIPGITGLEIQAGRTFFSDSSGTD--ENYINIFYNVTQLFADKPRY----------N GAAD---------LEGDEISLEAKLTNFN-IEIGK-RS--NDGVTED--EEFLKITYTCCNNSN---------------N GLFG--KDN--RQQNPAAITAGINYTPIPLVTVGIDRKQGSAGNGET--LFNLGVNYEVGTPWAK----QISP--DAVNA GLFG--VDN--RQKNPLAVTLGVNYTPIPLFTVGVDHKMGRAGMNDT--RFNLGFNYAFGTPLTH----QLDS--DAVAI ALFG--ESE--RQKNPHAITAGVTWTPFSLLTAGVDYRRGKNGADDT--RLNLGLTYRIGEPLAH----QLDS--SRVGA ALFD--DSEDDRQRNPYAVTAGVNYTPFPLVSIGLNQKMGKGNHNDT--QIDLAVNWMLGSSLKS----QLDS--DAVKA ALFG--LNE--RQKNPSALTASVSYTPFPLVNLALEHTIGNSGKNKT--GVNLAVNYEINTPWQK----QIDP--AAVKA ALFG--INE--RQKNPSALTAGVSYTPIPLVSLGLDHTIGNGGKKKT--GVNVAVNYEINTPWQQ----QIDP--AAVQT ALLN--HQN--RYKNPYALTMGLEYTPIQLISLGIDRTFSHRGKDDT--KVNLSFNYQLGVPLSQ----QIDP--TVAPV ALNSGSTSPDDLGDSPSAFTVGLNYTPIPLFTVDVAHKKGQNTNNEL--QLGLNFNYRFGVPWVD----QINK--NAVGL ALNSGSTSPDDLGDSPSAVTLGVNYTPIPLITVDVAHKKGQNTSNEL--QVGLNFNYRFGVPWID----QINK--DTVAL ALFG----KDNRQKNPHAITAGVNYTPIPLVTIGAEHRAGKGGQNDS--NINFQLNYRLGETWQS----HIDP--SAVAA ALFG----KDNRQKNPHAVTAGVNYTPIPLLTVGAEHRAGKGSKNDS--SINFQFNYRLGESWQS----HINP--SAVAA ALFG----KDDRQKNPYAFTAGINYTPIPLITIGAEQRAGKGGRNDT--NISIQLNYRLGEPWQS----QIDP--SAVAA ALFG----KDDRQKDPHAVTLGVNYTPVPLVTIGAEHREGKGNNNNT--SVNVQLNYRMGQPWND----QIDQ--SAVAA ALFG----KDNLQRNPYAVTAGINYTPVPLLTVGVDQRMGKSSKHET--QWNLQMNYRLGESFQS----QLSP--SAVAG ALFD----KDHLQSNPSAVTVGLNYTPVPLITAGIDYKRGQDSMDEM--KFSLNFHYALDSSWQS----QISP--EQVAT ALFG----KNKRQKDPYAATIGVNYTPIPLITAGIDYKLGKEGKSDG--IFSFNVNYRFGVPLSE----QLSP--ENVSS ALFN----SDKLQSNPGAATVGVNYTPIPLVTMGIDYRHGTGNENDL--LYSMQFRYQFDKPWSQ----QIEP--QYVNE ALFG----TKNLQQNPYSITAGLNYTPIPLVTFNAEHRQGKASKQDS--RFGLQLNYQFGKTWKQ----HLDP--GSVTT ALFG----TKNRQNNPYSITAGINYTPIPLITLNGEHRQGKASKQDS--RIGLKLSYQFGKSFKQ----HLDP--DAVGE ALFG----KENLQQDPRAITAGVNFTPFPLLTLNAEHRQGASGKNDK--RLGVDFSYQLGMPWQQ----QINP--QAVAT ALFG----KDNRQKDPHAITVGVNYTPFPLLTFSADQRQGKAGQNDT--RLGVQLNIQLGTPWQH----QLDT--SAVGA ALFG----ENHRQRNPHSTTLGISYTPFPLMSFKAEHKMGSNNINDS--RIGFEINYQIHTPWES----QINP--VLIPA GLFG----KDKRDKNPHTYTLGINYTPIPLVTLNAERRIGLHDRADN--NLNINLSYRIGESLAS----QLNP--DNVKA GLFG----SDNLQENPYAVTGEISYTPVPLVKFSAQHRQGQSNTHDT--RFGVEINYRPGVPLSK----QLDS--DNVAA GLFG----KDKRQKDPHAISAEVTYTPVPLLTLSAGHKQGKSGENDT--RFGLEVNYRIGEPLAK----QLDT--DSIRE ALFD----KDDRQSNPHAITAGLNYTPFPLMTFSAEQRQGKQGENDT--RFAVDFTWQPGSAMQK----QLDP--NEVDA ALFD----KNDRQSNPHAITAGLNYTPFPLLTLSAEQRQGKQGENDT--RFAVDLTWQPSSSMQK----QLNP--DEVAG ALFG----KDERQNDPHAITAGLSYTPVPLISFSAEQRQGKQGENDT--RIGMELTLQPGHSLQK----QLDP--AEVAA ALFG----RDHRQKDPHAFTAGVSYTPVPLVSLSAEQRQGKGGENDT--RFGLNLSYTPGVSLAR----QLDP--DAVAY ALFG----KDKRQQDPHAFTAGLSYTPVPLISLSAEQKQGKGGENDT--RFALNLTYTPGVSLAH----QLDP--DAVAY ALFG----KTKRQKNPNAATIGANWTPFPLFTLNASHKLGSEKQVET--QAKLQFTWTFGKNLAH----HLDP--TKVAE SLFG----RSDLQHDPFVITTGVEFTPFPLLSMEIDHRMSKASRHYT--LFNIRLNYRFGESLSS----QLNP--FSVAK DLFN----SGTGYHNPVALSLGLNYTPVPLVTVTAQHKQGESGENQN--NLGLNLNYRFGVPLKK----QLSA--GEVAE DLFD----SGTGYHNPVAVKLGLNYTPVPLVTVTAQHKQGESGVSQN--NLGLNLNYRFGVPLNK----QLSA--SEVAE DLFD----SGTGYHNPVALKLGLNYTPVPLLTMTARHKQGESGVSQN--NLGLTLNYRFGVPLKK----QLAA--SEVAQ DLFN----SGTGYHNPMAVNLGLDYTPVPLVTISAAHKQGESGVSQN--NLGLKLNYRFGVPLAK----QLSA--GEVAA DLFR----SGTGYHNPMAVNLGLDYTPVPLLTFSAAHKQGESGVSQN--NLGMKLNYRFGVPLKK----QLSS--EEVAT ELFD----SGTGYHNPVAVKVGLSYTPVPLVTVSAHHRQGESGVSQN--DLGLKLNYRFGVPLTK----QLSP--DEVAA DLFH----SGTGYHNPVAVSVGLNYTPVPLVTVTAKHKQGENGVSQN--NVGLKLNYRFGVPLKQ----QLAA--DEVAI DLFN----SGNRYHNPAALSLGLSYTPVPLVTISASHKTSSAGESQD--QLGLKLNYRFGVALSK----QLDA--NNVAE DLFN----SGNAVADPSAVSLGINYTPVPLFTLAASRKEGEGGESQN--QFTLKMNYRIGVPLRQ----QLSS--DNVAE DLFG----SGKKQNDPRAMQLGVNYTPVPLVTVKALHKMGEGGVSQD--QVELALNYRLGVPLVK----QISP--EYVAQ ALFG----KDNLQKDPSAVTVGVDYTPFPLATLKLIHKRGQQGKNNT--EVGLRVSYQIGTPLDK----QLDP--ANVAA ALFG----KDNLQKDPHAVTVGVDYTPFPLATLKVSHKMGKDGKNNT--ELGLQVSYQIGTALEK----QLDP--GNVAA ALFG----KEHLQKDPRAVTLGLDYTPFPLTTLKVSHKEGQQGQKEA--QVDLQMNYQIGTALSK----QLDP--DNVAA ALFG----KSHRQKDPRALTLGIDYTPVPLVTLGAKHKYGQQGKKDT--QIDVAFRYQFGSPLSA----QLDP--DNVNQ ALFG----TDSLEKDPFAVTLGVKYQPVPLIVVGTDFKAGTGDNTDL--SVNATLNYQFGVPLKD----QLDP--DKVSA ALFG----TDNLEKDPHAVTLGLNYQPVPLITVGTDFKTGTGDNTDV--TVNATLNYQFGTPLKD----QLDP--ENVKI ALFG----TDNLQKDPHAVTLGLEYTPVPLVTVGSDYKAGTGDNNDF--SVKATVNYQIGTPLAA----QLDP--ENVKI ALFG----TDNLEKNPQALTVGLMYNPVPLFTVGSDYKSGTGDNSDL--SVNVSLNYQIGMPLKD----QLDP--DNVKA GLLD----ADQLERDPHAITAGLHYNPFPLLKMDVEQVEASGRQHDT--RFTLGLEWKLGATLWD----MLNP--SSVDDLLG----NGTLSRNPRAAGAALVWNPVPLLEVRAGYRDAGNGGSQA--EGGLRVNYSFGTPLHE----QLDY--RNVGA DILG----NDSLTRDPAAFTGAITWKPVPLVEIKAGYKDAGSSGSQT--EAGLNLNYTFGVPLRA----QLDP--SQVRP DYFD----NGRTQAGAKGFKVGVEYRPVSLVSVGLEQTKVIGGGRET--RMQLGLNINLSEPLSK----QLRR-DASGTP DYFD----NGRTQDRATGFKYGVQYKPVPLLSLGVEQTRVIGGASQT--SVQLGVALNLSEPLSK----QLRR-GGE-TP DYFD----NGRPQRNARGYKYGVEYRPVPLVAVGLEQTKVLGGARQT--TVQLGVNLSLGEPLSR----QLR---HQSGP DYFD----DGRYRRNPSGFKYGIEYRPVPLIGVGVEQARLQSGERQT--SVQLGVRLNLGEPLSR----QLRRGAQDTAP DVFD----SGRAQRNASGFRYGVAYQPGALFNIGLNQTRTLDGQKQT--SVQLNVRINLQEPPSR----QLRR----ESQ QDNS--GLEGAVSWQATPHVGLEAYVSNEISAASTTANTDLPGTDEN--FFGLRMNITGNPVKFEK-----------SNY QDNS--GLEGAVSWQATPHVGLEAWVSNEISAASTTVNTSLPGTDET--FFGLRMNITGNPIKFEK-----------SNY QDNS--GLEGSVRWQATPHLGWEAYVSNEISAASTTVNTSLPGTDEI--FFGLRVNITGNPVTFGK-----------KDY QDNS--GIEGSFNWQATPHVNWEAWVSNEISGAKTVKNSDLPKTDET--FFGLRFRWTARPVKFAK-----------KNL SDNS--GIEGSVNWQATPHANLELWVSNEIPAYPTDSNDTIGNQPGP--YIGARVRLTGRPVVFTK-----------SNT SDNS--GVEGSVNWQATPHTNLSAWISSEIPAYPAQSNAQLSSGDDV--YVGVRFNVQLKPVTYKTG---------SNRI NDSN---NPIDDLKGNTFSVSGSVYDGLSVEVGYIDYTSGNADYSKAGGERFLKVSYNFDIFGTH----------VNKAT GIFG-ANSVDDLEKNPLIYEGGISYSPFPALTFTLSHSRSAESSKKN-TSINANINIPLDEKAMK---LAFEP--KLAGI NWKD----AASYETEHYEAGINAEIAPNLTLRVAAQHKKNSNNTEAV---ASINYSVPLGGANQP---AKVKQDGDWSTK .......250.......260.......270.......280.......290.......300.......310.......320

204 195 223 223 224 227 224 224 249 224 224 223 223 223 223 223 224 224 221 223 223 223 223 223 223 224 224 224 224 224 224 224 224 218 221 221 221 221 221 221 222 221 221 223 223 223 223 225 223 223 222 223 255 223 223 225 224 223 226 220 228 228 228 228 227 251 212 269 213


HQWISKDAYKLESMEDRRYEKVRRTN-------------------------------------NIVKQIKSLGVKVSGIEIGISDTAYNLTSVSDQKFAKVRRQN-------------------------------------LIVKQ-KEMDLTVIGFRRTLQGSRNDLVERNNQIVLEYKKQD-VINLYV-SNNVSGRAA------ET-----------KQLVVSV-TSKYGLRNIQ KRSLMGSRYNLVDRNNQIVMKYRKQN-RVTLEL-PARVSGAAR------QT-----------MPLVANA-TAQQGIDRLE QRSLAANRLELVNRNNDVVLEYRKQT-LITLQL-PPDVYGAEL------TT-----------VTLTPQV-NAKYGLSRIE RRTLLGSRLDLINRNNNIVLEYRKQD-LISLKV-QNKVTGTES------ET-----------LPVSVNV-KSKYPLDHIS TRTLAGSRMDLVDRNNNIVLEYRKQQ-VVTLNL-PAKVSGKEK------QV-----------LPINYTF-NARHGLDRIE TRTLAGRRMDLVDRNNNIVLEYRKQQ-VVTLNL-PEKVSGKEK------QV-----------VPINYTF-NARHGLDRIE KRTLADNRYHLVERNNNIVLKHRERA-QLSLYL-PTGLSGFGG------ER-----------KLINFSF-NGKYRLKHIQ MRSLMGSRYDIVDRNYNIVMQYEKQD-LIKLTL-PETLAAYAI------TN-----------LSLTGNI-TAKYGAERME MRSLAGSRYDLVDRNYNIVMQYEKQN-LINLTL-PETISAHAL------EN-----------VTLTGTV-ASKYGTERIE SRTLAGSRYDLVERNNHIVLDYQKQN-LVRLSL-PDSLAGDPF------SQ-----------LSVTAQV-TATHGLERID TRTLAGSRYDLVERNNNIVLDYQKQE-LIRLSL-PERVEGKAG------DI-----------ATVNAQV-TSKYGLERID SRTLAGSRYDLVERNNNIVLEYQKQD-LIQLVL-PNQMTGSAF------EI-----------IKVEAQV-TAKYGLKRID NRTLAGSRYDLVERNNNIVLDYKKQE-LIHLVL-PDRISGSGG------GA-----------ITLTAQV-RAKYGFSRIE TRLLAESRYNLVDRNNNIVLEYQKQQ-VVKLTLSPATISGLPG------QV-----------YQVNAQV-QGASAVREIV RRSLAGSRYDLVDRNNEIILQYKKK------------------------------------------------------LRSLAGSRYDLVERNNNIILNYLKKQ-QHFRLL-VPVIEISSY------GG-----------EVKPIQI-QSDTPFKNVT LRTLSGSRYDLVQRNNNIILEYKKQD-ILSLNI-PHDINGTER------ST-----------QKIQLIV-KSKYGLDRIV FRSLMGNRYDFVSRNNHIVLEYKKND-VIQLNI-ANSITGYAG------EK-----------IPLSFTV-ASKYGLSHLK FRSLMGNRYDFVSRNNHILLDYKKND-TIYLNM-NASITGISG------EK-----------IPLKYTI-NSQYGFNRIN MRSLAGSRYDLVERNNHILLQYRKKE-VIRLHT-VGRVTGYAG------ER-----------KSLGVSV-NSSYGLERID MRTLAGSRYDLVDRNNNIVLEYRKKE-VIHLYT-ADHLAGYAG------EQ-----------KSLNVSI-NTKYGLERID MRKLAGQRYDLVERNNNIILDYRKKE-IIKIDG-VDVISGFSG------EK-----------KRLDIRV-NSKYPVDRID IRTLAGSRYDFVNRNNDMILEYKKET-LVFLSM-VDSINGYAK------EE-----------RDLQVQV-KTKYPLANIE MREVQNRRYDFVERNNNIVLEYKKKS-TLRISL-PDAIEGESG------AT-----------IPVTLNVSHASNGIQSVQ RRVLAGSRYDLVERNNNIVLEYRKSE-VIRIAL-PERIEGKGG------QT-----------LSLGLVVSKATHGLKNVQ RRSLAGSRFDLVDRNNNIVLEYRKKE-LVRLTL-TDPVTGKSG------EV-----------KSLVSSL-QTKYALKGYN RRSLAGSRYDLIDRNNNIVLEYRKKE-LIRLSL-LDPVKGKSG------EI-----------KPLVSSL-QTKYALKGYN RRSLVGSRYDLVDRNNNIVLEYRKKE-LVRLTL-TDPLKGKPG------EV-----------KSLVSSL-QTKYALKGYD RRSLSGSRHDLVERNNNIVLEYRKKE-LVKLQL-NDPVTGKGG------EQ-----------KPLVASL-QSKYALKTLQ RRSLAGSRHDLVERNNNIVLEYRKKE-LVKLQL-HDPVTGKGG------EQ-----------KPLVASL-QSKYALKTLR TRRLSGNRYDFVERNNNIILNYQKKT-VLHLSL-PSKIQGITG------QS-----------VPLVKSF-TSKYPLKHIE MRFLNENRYNFVSRNHVIVFNYSEYT-YDIFVS-PASISAIEF------AS-----------STVSLKCPNTKT-LAHFE SQSLRGSRYDNPQRNNLPTLEYRQRK-TLTVFLATPPWDLKPG------ET-----------VPLKLQI-RSRYGIRQLI SQSLRGSRYDNPQRNNLPTMEYRQRK-TLTVFLATPPWDLQPG------ET-----------VPLKVQI-RSRHGVRHVT SQSLRGSRYDMPQRNALPTMEYRQRK-TLTVFLATPPWDLTPG------ET-----------VTLKLQV-RSVHGIRHLS TRSLRGSRYDPAERNSLPVMEFRQRK-TLSVYLATPPWDLKGG------ET-----------VMLKLQI-RSTHGIRQLH TRSLRGSRYDPVDRTSLPVMEFRQRK-TLSVYLATPPWDLTPG------ET-----------VVLKMQV-RSTHGVRQLH SRSLRGSRYDRVERTNVPVMEFRQRK-TLSVFLATPPWDLSAG------ET-----------VALKLQV-RSRHGIRQLS SNSLRGSRFDSPERDNLPVVEYRQRK-NLTVYLATPPWDLQSG------ET-----------VQLKLQI-HSLHGIKALH ARSLRGSRYDTVTRSQNPVMAYRQRK-TLSVFLATPPWQLNPG------ES-----------VPLKLQL-RASHSIKALS ARSLSGSRYDSVNRDNSPVMAFRQLK-TLSVFLATPPWQLQPG------ET-----------LRLKLQI-ANKNTIKAVS AKSLRGSRYDNIERKNVPVMAFKQRK-TLQVFLATPPWRLQPG------ET-----------LPLVLEI-KTTNKITRVS MRSLKGSRYDLVDRNNDIVLEYKEKA-SLALDLAAVPMTLLEG------DI-----------YLMQPLV-RSKYKIVGVT MRSLKGSRYDLVDRNYDIVLEYKEKA-VLSLDLAAVPMTLLEG------DV-----------YMMQPLV-RSKYRITSVS MRSLMGSRYDRVDRNYDIVLEYKEKAGLLMLDLAAVPATLLEG------DV-----------YLMQPLV-NGKYPIASVS LRSLKGSRYDLVDRNNDIVLEYKEKQ-VLFADLAAVPDSLMEG------ES-----------YILRPLV-KSKYPIIDLI AHSLMGSRHDFVERNNFIVLEYKEKD-PLYVTLWLKADVTNEHPECVIKDTPEEAIGLEKCKWTINALI-NHHYKIVAAS AHSLMGSRHDFVERNNFIVLEYREKD-HLDVTLWLKADATNEHPECVIKDTPEEAVGLEKCKWTVNALI-NHHYKIVAAS QHSLMGSRTDFVDRNNFIILEYREKD-PLDVTLWLKADATNEHPECVIEDTPEAAVGLEKCKWTVNALI-NHHYKIISAS KHSLMGSRHDFVERNNFIVLEYREQD-PLDVTLWLKADTANEHPECIVKDTPELAVGLEKCKWTINALI-NNHYKIVAAS -KSLAGMRHDLIERNNDMVLEYRDKV-LLKASL-NDQYSAVEG------QA-----------LTLTLNI-QHSRQIASIQ PSNTTN-RRAFVDRNYDIVMAYREQA--SKIRITAMPVSGLSG------------------TLVTLMATIDSRYPIEKVE ASNTTN-RTAFVDRNYNIVMEYREQA--SRIRVYASPVNGQSG------------------DTVTLSATINSRYPVERIE AFSPDARRHALVERENRIVLNTRRKEIILPLVVSKVSTLQADG--------------------RVTVIGATQPFATVTVR VFNLDAHRNALVERENRIVLNTRQKLIILPLTVTTVLTDSVSG--------------------RITLVGQTQAQATVNWT AFDLQARMGEFVERENRIVLQTRRKHVVLPLTIARVDTDPATG--------------------RITVTGVTEPGAQVSLG PFDRGARLQDFVRRENRIVLDTRRKKIVLALRIAEVRTDPATG--------------------RITVYGVTEPLADVQLW PFNLTSRRHQWVERESRIVLNTRRKAITLPLSIAQLRGDPTNG--------------------AIEVSGQTEAGARIMLT KKNMVTQMTQPVKRKYDVLLERSAG----------GVFQNR-------------------------------AKGV---KKNIITQMTQPVKRVNDVLLERAAINSS-----GAATFTVRVS-----------------------------AQGT---KKNMITQMTQPVKREYNVLLERYGAN---------STFTNR-------------------------------AKGS---KQNLVTQMTQPVRRRYEVLLERSTGG-----------FQNR-------------------------------ARGI---KQNLLTQMTQPVRRRYEVLLERVKEPTK-----GENGSITS-I-----------------------------AQGI---RENLLTQMRQPVQRRNDVLLERWKPKQKKTIGGVNGSFINQ-------------------------------AAGI---KPRFSNTPYEFERMDDRRFEKIRFEQKVISAHNNEQPPA----------------------------------------SNTIEGTRTQFIDRDYSMVLEYRATPNKYHISYCGDLGNDKHCILLKN-----------GFDEVVKNTPMRVTPTHSCVV FEPIREKLYRPVQRENRIMKKAIKLG---------VTVSGY--------------------------------------.......330.......340.......350.......360.......370.......380.......390.......400

246 236 283 283 284 287 284 284 309 284 284 283 283 283 283 284 249 284 281 283 283 283 283 283 283 285 285 284 284 284 284 284 284 278 282 282 282 282 282 282 283 282 282 284 284 284 285 286 301 301 300 301 314 282 282 285 284 283 286 280 263 270 264 262 268 296 251 338 245


----------------------------------------------------------------------------------------------FDQGA----------------LAAAGGKIIP----QGPSQFALQLPPQ WEASA----------------LTLAGGKITG----SG-NNWQITLPSY LDDAE----------------LRQAGGKIIS----NTGNQITLQLPAW WEDDN----------------LVKNGGKISE----NNG-SWSVTLPHY WDAAD----------------VINAGGNISD----QGNLAYHITFPPY WDAAD----------------VIKAGGQVIN----QGNLAYYIAMPPY WNDGA----------------LRARGGRIIA----LSNNSYVVQFPNY WSAPA----------------LMAAGGSIIP----LTMESASVTLPPY WSAPV----------------LVTTGGALTP----LAMESAVVTLPAY WQSAE----------------LMAAGGVLKQ----TSKNGLEITLPEY WDSAA----------------LIAAGGTLSK----GSSNSISITLPPY WDTAV----------------IVAAGGVVTQ----TSSQNISIKLPPY WDATP----------------LENAGGSTSP----LTQSSLSVTLPFY WSDAE----------------LIAAGGTLTP----LSTTQFNLVLPPY -----------------------------------------------WDIPE----------------LFQKNGGMIN--I-ESTHGYTIQLPEY WDDSS----------------LRSQGGQIQHSGS-QSAQDYQAILPAY WNAET----------------LVAAGGHIVQE-----NGKYSLVLPAY WHADS----------------LVAAGGQVIDEK----NGAYSIILPTY WSASS----------------LLAAGGKLVREN----EGSWSVILPEH WSAPE----------------LLAAGGKIVQES----IDNYSIVLPDY WLANT----------------FIANGGKIINEG----LHNYSIILPDY WSASK----------------LNAQGGQIKHHG----GTHYTVILPQY WSDSA----------------FAAAGGKITGS-----GTSWQFTLPAY WEAPS----------------LLAEGGKITGQ-----GSQWQVTLPAY VEATA----------------LEAAGGKVVTT-----GKDILVTLPAY IEAAA----------------LEAAGGKVSTS-----GKDITVTLPGY IEAAS----------------LQSAGGKVAVS-----GKDIQVTIPPY TDAAT----------------LTAAGGVISTA-----DNQVTVTLPAY AEAAE----------------LQSAGGVVNTE-----ANQVTVTLPEY WQAPE----------------FLAVGGSISSD-----DQTATLTLPSY WEAQN----------------FIEAGGEITLVSAGKSNAEYTVKLPPH WQGDT------------QILSLTPGAQANSAEG-------WTLIMPDW WQGDT------------QALSLTAGAKADSAEG-------WTIIMPAW WQGDT------------QALSLTAGTDTRNTEG-------WTIIMPAW WQGDT------------QALSLTSPANSTSSDG-------WSIIIPAW WQGDT------------HALSLTSPANANSDEG-------WSVIMPAW WQGDT------------QALSLTPPLDSTSADG-------WTVIMPAW WQGDT------------QALSLTPPVDASSPDG-------WSIIMPVW WQGDT------------QALSLTSPPNNNAIDG-------WSVIVPPW WQGDT------------QALSLTPPPDNSDPQG-------WSIIIPAW WQGDT------------QALSLTPSQNSNDPHG-------WSLIVPQW WNGDT------------VPLSLLATAGATNPQG-------WQITLPAW WHGDA------------VPLLLVPTAGANNPQG-------WQITLPAW WQGDT------------VPLALLATAGVDNHQG-------WQITLPAW WLGDL------------LPLQLLATAGSHNPQG-------WQITLPAW WQAKNNAASWQAKNNAARTLVMPVIKENTLTEGN---NNHWNLVLPAW WQAKN---------NAARTLVMPVIKENTLTEGN---NNRWNIVLPAW WQAKN---------NAARTLVMPVVKADALTEGN---NNSWNLVLPAW WQAKN---------NANRTLVMPVVKANALTEGN---NNRWNLVLPAW WLGDVLG--------------LSGLSPADTAGQ-----DKRALTLPSL WSGDA-----------------ELIAGLQLQGS-----LGSGLILPQL WTGDA-----------------ELIGGLQQQGN-----VNSGLRLPDL MPDGM-------------TGTATADASGRFAYTSAGDQPSGVLALRAR LPDGS-------------SGQSRADASGVYRIESRKDQPSGPIRLKAV LPNGE-------------VVVAQADGSGTYRATSARDMVGGPVRARAT LPDGT-------------ATSVRANAAGGFEASSAGDMTSGLIRARAT FPDGS-------------GNWVRADASGRYTARSGPDMPSGTVRAQAR -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FEKGFD--------------YITDNSGKVYVQIIRSCTPKTDLNAVAG -----------------------------------------------.......410.......420.......430.......440........

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