Myocardial iron quantification using modified Look-Locker inversion ...
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Myocardial iron quantification using modified Look-Locker inversion ...
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WORKSHOP PRESENTATION
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Myocardial iron quantification using modified Look-Locker inversion recovery (MOLLI) T1 mapping at 3 Tesla GC Camargo1*, T Rothstein1, FP Junqueira1, E Fernandes1, RL Lima1, A Greiser4, R Strecker5, JA Lima2, SS Xavier3, I Gottlieb1 From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013 Background Quantification of myocardial iron overload is critical for the management of patients with hemochromatosis. The effects of excess iron on T1 and T2* relaxation times correlate directly with tissue iron concentration. T2* became the clinical standard at 1.5T as it can be easily obtained in a fast one breath-hold ECG gated multi-echo GRE sequence. At 3T, however, T2* quantification can be limited by pronounced susceptibility artifacts and signal sampling restraints due to shorter T2* times at higher iron concentrations . Since myocardial T1 time is up to thirty times longer than T2*, it can be quantified with short echo-time inversionrecovery sequences even at high iron concentrations, and is less sensitive to susceptibility artifacts. We aimed to validate a recently developed modified LookLocker inversion recovery (MOLLI) sequence to quantify myocardial T1 in healthy controls and patients with iron overload at 3T, comparing to standard GRE based multi-echo T2* times at 1.5T. Methods A total of 15 normal volunteers and 7 chronic anemia patients (with a myocardial T2* measure
