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q qqqqq q q q q q. 19.88. 19.90. 19.92. 19.94. 0. 1. 2. 3. 4. 5. 6. Central America (N=109). Position on chr 8 (Mb). â lo g. 10. (P. ) q qq q q q q qq q q q qqqq q q q.

B

Central America (N=109)

Cuba (N=34)

6

6

5

5

4

4

− log10(P)

− log10(P)

A

3 2

3 2

●

1

●● ●●

● ●●

● ●

●

0

●● ● ●● ●

19.88

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19.90

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●

●● ●●● ●●

●

19.92

● ●●

● ●● ●● ● ●

19.94

19.88

19.90

5

5

4

4

3 ●

● ●

●●

1

●● ●

●

19.88

3

●● ●

●

● ●

● ● ● ● ● ●● ● ●

● ● ● ●● ● ●

●

● ● ●● ● ●

19.90

●

19.92

●

0

●

19.94

19.88

19.90

19.92

19.94

Position on chr 8 (Mb)

F

South America (N=123) 6 5

4

4

− log10(P)

5

3 2 1

● ●

●● ●●●

19.88

● ● ● ●● ● ●● ●●

19.90

● ● ●● ● ●

2

●

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19.92

Position on chr 8 (Mb)

● ●

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19.94

●

genotyped imputed rs328

3

1 ● ●●

●

2 1

6

− log10(P)

● ●

●

●

Puerto Rico (N=202)

0

19.94

●●

Position on chr 8 (Mb)

E

19.92

●

●

●

●

0

●

●

●● ●

●

●

Mexico (N=961) 6

− log10(P)

− log10(P)

D

6

●

● ●● ● ● ● ●

Position on chr 8 (Mb)

Dominican Republic (N=315)

2

●

0

Position on chr 8 (Mb)

C

●

●

1

●

0

●● ●●●

●

●

19.88

●●

●

● ●● ●

●

●

19.90

● ●● ● ● ● ●

19.92

Position on chr 8 (Mb)

●

●

19.94

●