R Graphics Output - PLOS

3000 2500 2000 1500 1000 500 0

Rank of Adjusted P−value

●●● ●● ●● ●●● ●● ●● ●● ● ● ●●●● ● ● ●● ● ● ● ● ● ●● ● ● ●● ● ●●● ● ● ●● ● ● ● ●● ●●●● ●● ● ● ● ●●●● ● ● ● ●●● ● ●●● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ●● ●● ●●●● ●● ● ●●● ●● ● ●● ● ●●● ●●● ● ● ● ● ● ● ●● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●● ● ● ● ●●●●● ●● ●●●●● ●● ●● ● ●● ● ●●● ●●●●● ●●● ● ●●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ●● ●● ●● ● ●●● ●● ● ● ● ●● ●● ●●●● ●● ●● ●● ●● ● ● ● ● ● ● ● ●●●● ●●●● ● ●● ● ●●●● ●● ●● ●● ● ● ● ●●●● ●● ●● ●● ● ● ● ● ● ●●● ● ●●●● ● ● ●● ●● ●● ●● ● ●● ●● ●● ●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ●●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●● ●● ● ●●●● ● ●● ● ● ●●● ●● ●●● ● ●● ● ●●● ● ● ● ● ● ●● ● ● ● ●● ●●● ● ●● ● ●● ● ●● ● ● ● ● ● ●●● ●● ● ●● ● ●● ●●●● ●● ● ● ●● ●● ● ●●● ●● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ●●● ● ● ●● ● ●● ● ●● ● ●● ● ●● ● ● ● ●● ●● ● ●● ●● ● ●● ● ● ●●● ●● ●● ● ● ●● ● ● ●● ●● ● ● ● ●●● ● ●● ●●●● ● ● ●● ● ●●● ●● ● ● ● ●●●● ●● ●●● ● ●● ●●● ● ● ●● ● ● ● ● ●● ● ●●●●● ●●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●● ● ●● ● ●●●● ● ● ●● ●● ●●●●● ●● ● ● ● ●● ● ●● ● ● ● ●●●● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ●●● ●● ● ● ●● ● ● ● ● ●● ●● ● ●●● ●●● ● ●●● ● ●●● ●● ●● ● ● ●● ●● ●●●● ● ● ●●● ● ● ●● ● ●●●● ● ●●●● ●●●●● ● ● ●● ●● ● ● ● ● ● ● ●● ●● ●● ●● ●●●●●● ●● ●● ●●● ●●● ●●● ● ●●● ● ●● ●● ●●● ● ● ●●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ●●● ● ● ● ● ●● ●● ●●● ● ●●●● ● ● ●● ● ●● ● ● ●● ● ● ●●● ● ●● ●●● ● ●● ● ●● ● ●● ●● ●●●● ● ● ● ●● ● ●● ● ● ● ●●● ● ●● ● ●●●● ●●● ● ●●● ● ● ●● ● ●● ● ● ●● ●● ●● ● ● ●●● ●●● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●● ●● ●● ●●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●●●● ●● ● ● ● ●● ●● ●● ● ●●● ●●●● ● ●● ● ●● ● ●● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ●● ●● ● ●● ● ● ●●● ● ●● ●●● ●●● ● ●● ●●● ● ●● ● ●● ● ●● ● ● ●●● ● ●● ●●● ●● ● ●●● ● ● ●● ● ●●● ● ● ●●●● ●● ● ●●●● ●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ●● ● ● ●● ●● ● ● ●●● ● ●● ● ●● ● ●● ● ● ● ● ●●● ● ●●● ●●● ● ● ● ● ● ● ● ● ● ●●●●●● ● ● ●● ● ●● ● ●●● ●● ●● ● ●● ●● ● ● ●●●● ● ● ●● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●● ●●● ●● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●● ● ●●● ●●●●● ●● ●● ●●●● ●● ● ● ● ● ● ● ●●● ●● ●● ● ● ●●● ● ●● ● ●●●● ●● ● ● ●●● ●●● ●● ●● ● ●● ●● ●● ●● ● ● ●● ● ● ● ● ●● ● ●●●● ● ●● ● ● ●●● ●●●●● ●●● ● ●● ●● ●● ● ● ●● ●● ● ● ●● ●● ●● ●● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ● ● ● ● ●●● ● ●●● ● ●● ●● ● ●● ●● ●● ●● ● ● ●● ● ● ● ● ●●●●● ● ● ●●● ●●● ●●●●●●● ● ● ●● ● ●● ● ● ● ● ● ●● ●● ● ● ● ● ● ●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●●● ●● ● ●● ●● ● ● ● ● ● ● ●●● ● ●●●●● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ●●●● ● ● ● ● ●● ●● ●● ●●●● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ●● ●●●●● ● ●● ●●●● ● ●●● ●● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ●●● ●● ● ● ●● ● ● ●● ●●●● ●●● ●●● ● ●● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ●● ● ●● ●● ● ●● ● ● ● ● ● ● ● ●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ●● ●●● ● ● ● ●● ● ●●●●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ●● ● ● ●● ● ● ● ●● ●● ●● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●●●● ● ● ●●● ●●●●● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ●● ● ● ● ●● ● ● ● ●●● ●● ● ● ●● ●● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ●●●● ●● ● ● ● ● ●● ●●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ●●● ● ● ● ●● ● ●● ●● ● ● ●● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●●● ●●● ● ● ● ●● ●● ●● ● ● ● ● ●●● ● ● ● ●●●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●

0

500

1000

1500

2000

2500

Rank of Unadjusted P−value

3000