S1 Table. Association (kon) and dissociation (koff) rate constants for ...
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S1 Table. Association (kon) and dissociation (koff) rate constants for ...
S1 Table. Association (kon) and dissociation (koff) rate constants for the inhibitors of tumor necrosis factor α (TNF-α), transforming growth factor β. (TGF-β), and ...
S1 Table. Association (kon) and dissociation (koff) rate constants for the inhibitors of tumor necrosis factor α (TNF-α), transforming growth factor β (TGF-β), and the chemokine CXCL8. Inhibited cytokine TNF-α TGF-β CXCL8
kon (nM-1·h-1) 0.93 13.35 3.25
koff (h-1) 4.69 0.00123 0.830
Ref. [20] [77] [78]
References 77.
78.
De Crescenzo G, Pham PL, Durocher Y, O'Connor-McCourt MD. Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding. J Mol Biol. 2003;328: 1173-1183. Yang XD, Corvalan JR, Wang P, Roy CM, Davis CG. Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states. J Leukoc Biol. 1999;66: 401-410.