Table S1 page 1/159. Page 2. Table S1 page 2/159. Page 3. Table S1 page 3/159. Page 4. Table S1 page 4/159. Page 5. Table S1 page 5/159. Page 6. Table ...
Protein name
Accession No.
Apolipoprotein A-I-binding protein
AIBP_HUMAN APOA1BP
Kunitz-type protease inhibitor 1
SPIT1_HUMAN SPINT1
DNA replication licensing factor MCM2 Multifunctional protein ADE2
MCM2_HUMAN MCM2
Matrilysin
MMP7_HUMAN MMP7
Antithrombin-III
ANT3_HUMAN SERPINC1
Tumor protein D52
TPD52_HUMAN TPD52
Histone H2B type 1-C/E/F/G/I
H2B1C_HUMAN HIST1H2BC
Kynureninase
KYNU_HUMAN KYNU
Gene symbol
PUR6_HUMAN PAICS
Serine/threonine-protein phosphatase PP2BA_HUMAN PPP3CA 2B catalytic subunit alpha isoform
Heterogeneous nuclear ribonucleoproteins A2/B1
ROA2_HUMAN HNRNPA2B1
Supporting Table S1. List of proteins identified in the BxPC-3 conditioned medium No. of No. of Molecular Protein Spectral Sequence Peptide sequence unique unique weight (Da) probability counts coverage peptides spectra 20.10% GLTVPIASIDIPSGWDVEK 8 4 4 100.00% 31,657 GNAGGIQPDLLISLTAPK KSATQFTGR LFGYEPTIYYPK 20.20% AWAGIDLK 77 11 10 100.00% 58,379 DPNQVELWGLK EGFINYLTR GSSGAQATFPQGPSMER KDPNQVELWGLK SFVYGGCLGNK TQGFGGSGIPK VQPQEPLVLKDVENTDWR WYYDPTEQICK YTSGFDELQR 2.65% GLALALFGGEPK 4 2 2 100.00% 101,880 VAVGELTDEDVK 6.35% EIVLADVIDNDSWR 3 2 2 99.50% 47,062 VTSAHKGPDETLR 9.74% DLPHITVDR 4 3 3 100.00% 29,660 FYLYDSETK NANSLEAK 10.60% FDTISEK 43 7 7 100.00% 52,586 FSPENTR FSPENTRK LPGIVAEGR LQPLDFK RVWELSK TSDQIHFFFAK 16.10% LGINSLQELK 5 3 3 100.00% 24,310 TSETLSQAGQK VEEEIQTLSQVLAAK 38.90% AMGIMNSFVNDIFER 17 5 5 100.00% 13,889 EIQTAVR IAGEASR LLLPGELAK QVHPDTGISSK 11.40% FTNLLTSILDSAETK 12 5 5 100.00% 52,335 FTNLLTSILDSAETKN IAAYGHEVGK TYLEEELDKWAK VAPVPLYNSFHDVYK 10.20% DAMPSDANLNSINK 7 4 4 100.00% 58,672 GLTPTGMLPSGVLSGGK IITEGASILR LFEVGGSPANTR 43.60% DYFEEYGK 314 20 17 100.00% 37,412 EDTEEHHLR
Peptide probability 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
Mascot Mascot No. of identified spectra No. of Calculated ion identity 2+ tryptic 3+ 4+ MH+ score score spectra spectra spectra termini 47.3 20.1 3 0 0 2 1,997.06 64.2 17.8 2 0 0 2 1,764.99 36.0 21.6 1 0 0 2 995.53 51.2 23.9 2 0 0 2 1,490.76 31.2 24.8 1 0 0 2 873.48 45.8 21.3 2 0 0 2 1,298.67 53.5 22.0 26 0 0 2 1,112.57 67.5 18.5 16 0 0 2 1,723.77 69.1 20.6 7 4 0 2 1,426.77 49.7 21.8 2 0 0 2 1,201.57 37.8 23.4 4 0 0 2 1,048.54 94.9 21.5 1 0 0 2 2,166.12 37.0 19.0 2 0 0 2 1,502.66 61.5 20.6 12 0 0 2 1,215.56 68.1 21.6 2 0 0 2 1,172.67 64.2 23.0 2 0 0 2 1,274.65 36.8 22.4 1 0 0 2 1,644.82 23.8 21.9 0 0 2 2 1,410.73 31.8 21.6 1 0 0 2 1,065.57 30.2 22.6 1 0 0 2 1,165.54 40.7 22.4 2 0 0 2 846.43 44.1 22.4 11 0 0 2 839.42 32.0 23.8 2 0 0 2 850.41 32.2 23.6 1 0 0 2 978.50 49.2 19.0 13 0 0 2 911.53 34.7 23.9 2 0 0 2 860.49 33.6 22.4 4 0 0 2 917.52 57.3 22.1 10 0 0 2 1,340.66 40.3 21.5 1 0 0 2 1,114.65 62.2 23.1 2 0 0 2 1,149.58 55.2 20.9 2 0 0 2 1,657.90 114.0 21.8 13 0 0 2 1,743.82 34.3 23.8 1 0 0 2 816.46 41.5 24.5 1 0 0 2 703.37 32.5 13.8 1 0 0 2 953.60 45.9 22.5 0 1 0 2 1,168.60 101.0 21.6 4 0 0 2 1,652.87 62.8 21.4 4 0 0 2 1,766.92 64.8 22.5 2 0 0 2 1,044.55 38.9 23.1 1 0 0 2 1,524.76 44.0 22.5 1 0 0 2 1,748.90 39.2 19.9 2 0 0 2 1,505.69 61.0 22.2 2 0 0 2 1,587.84 45.4 19.3 1 0 0 2 1,072.64 48.4 23.8 2 0 0 2 1,247.64 33.2 15.4 2 0 0 2 1,050.44 44.3 20.9 5 0 0 2 1,165.52 Table S1 page 1/159
Glutaredoxin-3
GLRX3_HUMAN GLRX3
37,415
100.00%
5
5
8
17.90%
Laminin subunit gamma-1
LAMC1_HUMAN LAMC1
177,583
100.00%
26
29
355
19.20%
Flap endonuclease 1
FEN1_HUMAN FEN1
42,576
100.00%
4
4
9
15.30%
Phosphoserine phosphatase
SERB_HUMAN PSPH
24,990
100.00%
2
2
2
11.60%
EESGKPGAHVTVK GFGFVTFDDHDPVDK GFGFVTFDDHDPVDKIVLQK GGGGNFGPGPGSNFR GGNFGFGDSR GGSDGYGSGR IDTIEIITDR KLFIGGLSFETTEESLR LFIGGLSFETTEESLR LFVGGIK LFVGGIKEDTEEHHLR LTDCVVMR NYYEQWGK QEMQEVQSSR TLETVPLER AYSNWPTYPQLYVK ENGELLPILR GELVGGLDIVK LEAEGVPEVSEK YEISSVPTFLFFK AFDITYVR AHVENTER ALAEEAAK CELCDDGYFGDPLGR CIYNTAGFYCDR DGFFGNPLAPNPADK DGSEASLEWSSER DTLQEANDILNNLK EAQDVKDVDQNLMDR EAQQALGSAAADATEAK EVVCTNCPTGTTGK GKTEQQTADQLLAR HKQEADDIVR LIEIASR LNEIEGTLNK LNTFGDEVFNDPK LSAEDLVLEGAGLR MEAENLEQLIDQK NTIEETGNLAEQAR QDIAVISDSYFPR QLQEAEK TEQQTADQLLAR TFAEVTDLDNEVNNMLK TGQCECQPGITGQHCER TKEVVCTNCPTGTTGK VSVPLIAQGNSYPSETTVK EAHQLFLEPEVLDPESVELK KLPIQEFHLSR LIADVAPSAIR QLQQAQAAGAEQEVEK LIAEQPPHLTPGIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
55.6 86.5 39.2 66.3 63.1 74.0 101.0 80.3 109.0 34.6 41.6 35.6 37.4 68.4 40.4 32.0 46.4 35.5 43.9 44.0 54.3 34.5 48.1 71.6 33.8 71.3 73.9 79.1 45.7 133.0 41.7 88.3 47.0 53.3 52.3 88.2 123.0 92.1 98.8 88.3 39.5 60.2 110.0 69.2 57.1 109.0 43.2 27.6 54.0 107.0 32.1
22.6 20.5 21.3 21.1 17.4 16.1 23.1 20.7 21.8 16.5 21.8 22.9 19.1 19.7 20.9 22.2 19.1 21.6 22.8 22.6 21.6 20.7 21.6 14.1 14.6 21.8 16.5 21.6 22.1 22.7 19.8 22.9 23.1 22.3 24.2 22.7 21.8 21.8 22.3 22.8 22.0 22.6 21.6 14.5 21.7 20.5 20.8 17.6 17.2 22.1 17.6
8 23 0 24 19 2 30 2 112 1 0 2 2 29 11 1 2 2 2 1 12 1 9 2 1 16 5 9 3 26 1 5 0 4 9 36 58 20 21 20 1 2 13 0 1 36 0 0 3 3 0
0 14 9 0 0 0 0 1 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 6 0 0 23 0 0 0 2 0 0 0 0 0 0 11 0 0 2 1 0 0 1
0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,338.70 1,695.77 2,277.16 1,377.63 1,013.44 912.38 1,188.65 1,927.02 1,798.92 733.46 1,879.97 993.49 1,087.48 1,237.55 1,057.59 1,729.86 1,153.66 1,099.64 1,286.65 1,577.83 984.52 955.46 802.43 1,773.72 1,539.64 1,559.75 1,452.62 1,600.82 1,791.82 1,631.79 1,523.68 1,558.82 1,210.62 801.48 1,130.61 1,495.71 1,442.79 1,576.75 1,545.75 1,510.75 845.44 1,373.70 1,968.92 2,017.83 1,752.83 1,990.05 2,322.19 1,367.78 1,125.66 1,727.86 1,541.88
Table S1 page 2/159
Complement C1r subcomponent
C1R_HUMAN C1R
80,102
100.00%
14
14
67
LNIPATNVFANR 22.60% FCGQLGSPLGNPPGK FCGQLGSPLGNPPGKK GGGALLGDR IAHDLR LGNHPIR LPVANPQACENWLR MGNFPWQVFTNIHGR QDACQGDSGGVFAVR QRPPDLDTSSNAVDLLFFTDESGDSR
TLDEFTIIQNLQPQYQFR VLNYVDWIK VLNYVDWIKK WILTAAHTLYPK YTTTMGVNTYK Eukaryotic translation initiation factor 3 subunit A
EIF3A_HUMAN EIF3A
166,557
100.00%
3
3
4
Crk-like protein
CRKL_HUMAN CRKL
33,759
100.00%
2
2
3
Rap1 GTPase-GDP dissociation stimulator 1 Eukaryotic initiation factor 4A-III
GDS1_HUMAN RAP1GDS1
66,300
99.90%
2
2
3
IF4A3_HUMAN EIF4A3
46,854
100.00%
4
4
6
T-complex protein 1 subunit alpha
TCPA_HUMAN TCP1
60,327
100.00%
8
9
17
3.62% EQPEKEPELQQYVPQLQNNTILR FNVLQYVVPEVK LTSLVPFVDAFQLER 8.91% IHYLDTTTLIEPAPR TALALEVGDIVK 4.28% EQFASTNIAEELVK SVAQQASLTEQR 16.50% ETQALILAPTR GIYAYGFEKPSAIQQR GRDVIAQSQSGTGK LDYGQHVVAGTPGR MLVLDEADEMLNK 18.50% AFHNEAQVNPER AFHNEAQVNPERK FATEAAITILR MLVDDIGDVTITNDGATILK QAGVFEPTIVK SLLVIPNTLAVNAAQDSTDLVAK
Serpin B9
SPB9_HUMAN SERPINB9
42,386
100.00%
13
15
57
Neutral amino acid transporter B(0)
AAAT_HUMAN SLC1A5
56,582
100.00%
3
3
31
SSLGPVGLDK YINENLIVNTDELGR 41.20% ADLSAMSAER AFQSLLTEVNK AQLLELPYAR GKWNEPFDETYTR GNTATQMAQALSLNTEEDIHR HLGIVDAFQQGK IEELLPGSSIDAETR INQEEQRPVQMMYQEATFK LAHVGEVR LQEDYDMESVLR LVLVNAIYFK STEVEVLLPK TEGKIEELLPGSSIDAETR WNEPFDETYTR 8.13% EVLDSFLDLAR NIFPSNLVSAAFR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
50.7 82.3 44.7 53.4 35.3 40.9 77.4 62.2 39.2 71.1 88.4 50.3 29.4 67.2 54.9 27.4 50.5 33.4 32.4 45.0 54.1 73.8 48.5 71.7 66.6 28.4 64.5 39.6 28.8 35.5 127.0 38.5 95.7 32.7 61.0 76.8 77.6 59.0 51.8 28.7 67.4 85.9 63.3 55.9 65.1 32.0 61.4 50.0 35.5 69.9 35.7
21.6 22.4 21.8 21.5 19.2 20.5 22.4 23.2 19.2 20.3 22.2 21.5 18.8 20.0 21.2 20.6 19.0 20.2 20.9 19.7 22.6 23.3 19.8 21.2 23.3 22.1 22.1 21.3 22.1 19.2 21.5 21.8 15.4 21.5 22.5 20.8 21.1 22.1 20.4 21.5 21.4 23.1 21.6 19.0 22.0 14.0 21.8 22.3 19.3 22.7 21.7
1 3 0 4 2 2 4 0 1 0 10 5 0 2 12 0 2 1 0 1 2 1 2 3 1 0 2 2 0 2 2 2 4 1 2 9 5 7 1 0 4 3 0 4 3 4 5 0 2 9 2
0 0 4 0 0 0 0 12 0 5 0 0 1 0 0 1 0 0 2 0 0 0 0 2 0 1 0 0 1 0 0 0 0 0 0 0 0 0 2 2 1 0 7 0 0 0 0 2 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,329.73 1,528.76 1,656.85 815.44 724.41 806.46 1,667.83 1,819.87 1,566.70 2,882.34 2,254.15 1,149.63 1,277.73 1,413.79 1,294.60 2,794.44 1,434.80 1,734.94 1,739.93 1,228.72 1,578.80 1,317.68 1,212.70 1,827.94 1,403.72 1,469.75 1,552.72 1,411.67 1,539.77 1,205.69 2,120.08 1,188.66 2,353.30 972.54 1,762.90 1,066.48 1,249.68 1,173.66 1,642.75 2,300.09 1,312.70 1,629.83 2,370.12 880.50 1,497.69 1,179.71 1,114.64 2,045.04 1,457.63 1,277.67 1,435.77
Table S1 page 3/159
Integrin alpha-3
ITA3_HUMAN ITGA3
118,740
100.00%
9
9
25
Glia-derived nexin
GDN_HUMAN SERPINE2
43,985
100.00%
4
4
20
Major vault protein
MVP_HUMAN MVP
99,308
100.00%
12
12
22
SELPLDPLPVPTEEGNPLLK 9.57% AAFVSEQQQK ARPVINIVHK EAGNPGSLFGYSVALHR GNSYMIQR LQSFFGGTVMGESGMK TVEDVGSPLK VYIYHSSSK YLLLAGAPR YTQVLWSGSEDQR 14.10% DMIDNLLSPDLIDGVLTR SYQVPMLAQLSVFR TIDSWMSIMVPK VLGITDMFDSSK 18.90% ALQPLEEGEDEEK DITPLQVVLPNTALHLK DLAVAGPEMQVK DQAVFPQNGLVVSSVDVQSVEPVDQR
Receptor-type tyrosine-protein phosphatase kappa
PTPRK_HUMAN PTPRK
162,085
100.00%
13
15
95
10.60%
Ras-related protein Rap-1b
RAP1B_HUMAN RAP1B
20,807
100.00%
3
3
5
16.80%
Ras-related protein Rab-11B
RB11B_HUMAN RAB11B
24,471
100.00%
5
5
20
30.30%
10 kDa heat shock protein, mitochondrial
CH10_HUMAN HSPE1
10,914
100.00%
6
7
25
60.80%
HYCTVANPVSR LAQDPFPLYPGEVLEK LFSVPDFVGDACK QAIPLDENEGIYVQDVK QMTEAIGPSTIR TAVFGFETSEAK VLFAPMR VPHNAAVQVYDYR CVTQSER ESEETIIQTDEDVPGPVPVK GLNPGTLNILVR GSGVSNFAQLIVR IAEIQAR KESEETIIQTDEDVPGPVPVK LWHLDPDTEYEIR MILTNPEGR MTSGSWTETHAVNAPTYK NGEDIPVAQTK TDQDLYR TYQGFWNPPLAPR VLLTRPGEGGTGLPGPPLITR EQGQNLAR INVNEIFYDLVR LVVLGSGGVGK AQIWDTAGQER GAVGALLVYDIAK NNLSFIETSALDSTNVEEAFK STIGVEFATR VVLIGDSGVGK GGIMLPEK GKGGEIQPVSVK KFLPLFDR SAAETVTK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
69.7 50.1 34.1 72.3 39.7 91.2 47.0 30.5 60.5 67.9 69.7 64.0 64.9 74.6 40.0 45.3 58.1 37.1 53.1 60.8 35.7 74.8 40.3 49.7 30.1 26.8 35.2 82.2 65.7 73.5 41.5 46.9 45.2 33.3 55.3 38.7 35.1 53.1 58.2 45.7 90.8 45.1 54.2 70.3 117.0 53.8 64.8 51.9 41.9 30.9 39.8
18.7 23.2 11.5 22.6 20.2 21.9 22.6 21.9 19.5 22.0 22.2 21.3 23.0 22.3 21.3 13.6 22.1 21.2 22.5 20.6 22.1 21.9 23.9 22.0 22.6 22.8 21.7 22.0 16.3 21.4 21.7 21.9 21.8 23.9 20.2 22.5 21.3 23.0 12.8 20.6 21.8 17.8 21.8 17.9 21.4 21.4 19.8 25.3 21.6 19.3 24.1
20 6 0 2 2 4 1 1 4 2 9 4 2 5 2 2 4 0 1 3 1 2 2 2 1 0 1 4 13 22 2 0 2 1 3 4 5 2 3 1 3 1 3 9 2 2 4 2 1 1 2
0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 5 8 0 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,158.17 1,135.57 1,146.71 1,774.89 984.46 1,691.78 1,044.56 1,083.55 973.58 1,568.73 2,016.03 1,654.86 1,439.69 1,328.64 1,486.69 1,872.10 1,257.65 2,812.41 1,303.62 1,815.95 1,454.70 1,930.98 1,303.67 1,286.63 849.47 1,531.77 879.40 2,182.08 1,266.75 1,347.74 800.46 2,310.17 1,686.81 1,030.54 1,996.91 1,171.60 910.43 1,546.78 2,101.21 915.46 1,494.80 985.60 1,274.61 1,289.75 2,329.12 1,080.57 1,043.61 860.46 1,198.68 1,035.60 806.43
Table S1 page 4/159
117,956
99.50%
2
2
3
2.65%
URP2_HUMAN FERMT3
75,937
100.00%
3
3
5
7.35%
VASP_HUMAN VASP
39,811
100.00%
5
6
18
12.10%
35,062
99.90%
2
2
3
8.71%
18,031
99.50%
2
2
7
25.00%
Insulin-degrading enzyme
IDE_HUMAN
Fermitin family homolog 3
Vasodilator-stimulated phosphoprotein
IDE
Electron transfer flavoprotein subunit ETFA_HUMAN ETFA alpha, mitochondrial CA123_HUMAN C1orf123 UPF0587 protein C1orf123 Podocalyxin-like protein 1
PODXL_HUMAN PODXL
58,617
100.00%
2
2
12
4.66%
Biotinidase
BTD_HUMAN BTD
61,115
100.00%
3
3
15
9.94%
VLQATVVAVGSGSK VVLDDKDYFLFR ESLDDLTNLVVK NEFIPTNFEILPLEK LEGSAPTDVLDSLTTIPELK SQDEAPGDPIQQLNLK VVLAGGVAPALFR DESANQEEPEAR QEEASGGPTAPK QVWGLNFGSK TPKDESANQEEPEAR VPAQSESVR GLLPEELTPLILATQK LEVAPISDIIAIK ATLENITNLRPVGEDFR ENSIEILSSTIKPYNAEDNENFK LASVPGSQTVVVK LGDQGPPEEAEDR LSSGLVTAALYGR QEALELMNQNLDIYEQQVMTAAQK
MA2B2_HUMAN MAN2B2
113,961
100.00%
3
3
4
Membrane-bound transcription factor MBTP1_HUMAN MBTPS1 site-1 protease DSG1_HUMAN DSG1 Desmoglein-1
117,732
99.90%
2
2
6
113,731
100.00%
6
6
52
RS19_HUMAN RPS19
16,043
99.50%
2
2
3
Poliovirus receptor-related protein 2 PVRL2_HUMAN PVRL2
57,724
100.00%
3
3
4
Epididymis-specific alphamannosidase
40S ribosomal protein S19
Protein-glutamine gammaglutamyltransferase 2
TGM2_HUMAN TGM2
77,311
100.00%
10
11
49
Bleomycin hydrolase
BLMH_HUMAN BLMH
52,545
100.00%
3
3
5
Urokinase-type plasminogen
UROK_HUMAN PLAU
48,490
100.00%
10
11
45
TSIYPFLDFMPSPQVVR 3.96% IEQEYQAGPLELNR LWWDGVASDQQK QGPISDNYLFTPGK 2.38% QRPPSGAGSVTPER VAVFDTGLSEK 8.67% EMQDLGGGER ISGVGIDQPPYGIFVINQK QEPSDSPMFIINR VGDFVATDLDTGRPSTTVR YQGTILSIDDNLQR YVMGNNPADLLAVDSR 13.10% IAGQVAAANK VLQALEGLK 7.62% MGPSFPSPKPGSER VEHESFEEPALIPVTLSVR VQVLPEVR 18.00% ALLVEPVINSYLLAER CLGIPTR DLYLENPEIK LAEKEETGMAMR LVVNFESDKLK NEFGEIQGDK TVEIPDPVEAGEEVK VVTNYNSAHDQNSNLLIEYFR YLLNLNLEPFSEK YPEGSSEER 8.13% IGPITPLEFYR LYTVEYLSNMVGGR TLYNNQPIDFLK 21.80% DKPGVYTR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
97.7 71.9 38.1 47.5 68.2 32.1 55.1 43.7 30.2 43.2 60.3 37.2 46.2 34.0 40.0 63.2 49.7 57.9 46.8 39.6 56.0 50.7 31.9 60.4 39.3 31.6 56.9 58.2 59.3 31.2 67.7 69.9 51.8 35.2 27.2 33.9 33.9 91.4 37.5 49.4 43.5 36.6 52.0 36.6 39.5 88.8 58.2 38.0 37.3 36.1 31.4
19.1 22.1 22.8 21.4 20.4 22.4 15.4 16.2 21.4 23.0 20.3 21.5 12.8 12.3 21.3 21.4 18.3 20.3 19.7 21.9 21.8 22.8 22.0 22.7 22.4 22.4 17.2 18.6 22.7 21.8 22.7 22.6 20.0 16.2 22.0 20.3 16.6 15.3 24.7 22.9 21.0 19.6 22.4 22.7 21.4 21.7 17.7 20.4 22.7 22.1 23.4
2 4 1 2 2 1 2 2 1 1 3 2 2 1 0 0 8 4 4 0 9 1 1 2 0 2 10 22 7 0 1 11 2 1 0 0 2 18 1 2 0 2 2 2 0 6 1 2 2 1 1
0 13 0 0 0 0 0 0 0 0 9 0 0 0 3 4 0 0 0 2 0 0 0 0 4 0 0 0 0 1 0 0 0 0 1 1 0 2 0 0 6 0 0 0 7 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,315.76 1,529.80 1,345.72 1,803.95 2,099.11 1,752.88 1,269.77 1,374.58 1,171.56 1,135.59 1,700.77 972.51 1,736.02 1,381.83 1,945.01 2,655.28 1,284.75 1,412.63 1,307.73 2,808.36 2,013.02 1,659.83 1,432.69 1,536.77 1,438.74 1,165.61 1,107.47 2,045.11 1,549.73 2,007.02 1,635.83 1,750.84 942.54 970.59 1,473.72 2,152.13 939.56 1,800.03 816.44 1,233.64 1,397.64 1,291.73 1,136.52 1,611.81 2,497.21 1,579.84 1,053.45 1,305.72 1,617.79 1,465.77 935.50
Table S1 page 5/159
activator
Latent-transforming growth factor beta-binding protein 1 Heterogeneous nuclear ribonucleoprotein L
LTBP1_HUMAN LTBP1
186,769
99.50%
2
2
4
HNRPL_HUMAN HNRNPL
64,115
100.00%
6
8
27
DYSADTLAHHNDIALLK EDYIVYLGR FEVENLILHK KEDYIVYLGR KPSSPPEELK LNSNTQGEMK MLCAADPQWK SDALQLGLGK VSHFLPWIR 1.57% EEPVEALTFSR TSTDLDVDVDQPKEEK 15.60% ISRPGDSDDSR NDQDTWDYTNPNLSGQGDPGSNPNKR
Golgi membrane protein 1
GOLM1_HUMAN GOLM1
45,315
100.00%
10
11
71
29.90%
Septin-2
SEPT2_HUMAN SEPT2
41,470
100.00%
6
6
25
19.70%
Peptidyl-prolyl cis-trans isomerase FKBP1A Protein disulfide-isomerase A3
FKB1A_HUMAN FKBP1A
11,933
99.50%
2
2
7
25.00%
PDIA3_HUMAN PDIA3
56,767
100.00%
32
40
439
59.60%
SDALETLGFLNHYQMK SKPGAAMVEMADGYAVDR SSSGLLEWESK TPASPVVHIR DLSENNDQR DQLVIPDGQEEEQEAAGEGR DTINLLDQR GNVLGNSK IQSSHNFQLESVNK LPQEPGR LQQDVLQFQK NIDVFNVEDQKR QQLQALSEPQPR QVEKEETNEIQVVNEEPQR ASIPFSVVGSNQLIEAK HIIDNR ILDEIEEHNIK STLINSLFLTDLYPER TIISYIDEQFER VNIVPVIAK GVQVETISPGDGR GWEEGVAQMSVGQR DASIVGFFDDSFSEAHSEFLK DGEEAGAYDGPR DLLIAYYDVDYEK DPNIVIAK EATNPPVIQEEKPK EATNPPVIQEEKPKK ELSDFISYLQR FEDKTVAYTEQK FIQENIFGICPHMTEDNKDLIQGK FISDKDASIVGFFDDSFSEAHSEFLK
FLDAGHK FLQDYFDGNLK FLQDYFDGNLKR FVMQEEFSR GFPTIYFSPANK GFPTIYFSPANKK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
32.3 48.3 36.3 54.6 55.3 69.7 37.1 86.8 32.3 40.2 72.0 42.9 79.9 61.3 29.5 62.5 41.0 40.0 103.0 59.8 30.1 88.2 38.6 42.6 45.1 58.9 40.8 74.9 30.8 45.5 51.9 66.1 36.9 61.7 107.0 36.7 66.1 88.1 45.8 80.2 42.3 64.7 45.8 43.0 28.6 31.2 71.8 58.2 53.2 61.3 65.6
22.6 21.1 20.8 22.0 21.8 22.2 19.5 22.2 19.9 23.6 22.1 20.6 17.6 22.1 21.7 23.0 20.1 18.3 21.0 23.4 24.3 22.5 18.9 22.1 23.0 22.4 21.9 19.9 20.6 22.2 20.5 22.5 10.4 21.8 21.5 20.5 14.9 22.2 16.4 21.6 20.3 22.5 22.3 21.6 20.8 21.6 22.1 22.5 18.5 22.5 21.2
0 2 4 5 10 4 1 12 0 2 2 1 0 8 0 8 0 4 6 10 1 4 8 6 1 14 0 8 1 3 4 6 3 2 5 1 17 53 4 17 1 33 0 0 0 1 9 12 38 18 4
2 0 0 0 3 0 0 0 1 0 0 2 2 3 1 0 2 0 0 0 0 11 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 6 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,896.95 1,127.57 1,241.69 1,255.67 1,111.60 1,121.53 1,235.56 1,001.56 1,154.65 1,277.64 1,818.86 1,204.56 2,890.26 1,866.91 1,867.87 1,222.60 1,076.62 1,090.48 2,169.99 1,087.58 788.43 1,630.82 796.43 1,246.68 1,476.74 1,394.74 2,298.12 1,759.96 767.42 1,352.71 1,882.00 1,513.75 952.62 1,314.67 1,533.71 2,348.07 1,236.51 1,619.78 869.51 1,579.83 1,707.93 1,370.70 1,458.71 2,863.38 2,938.38 787.41 1,359.66 1,515.76 1,188.54 1,341.68 1,469.78
Table S1 page 6/159
IFRDGEEAGAYDGPR KAQEDL KTFSHELSDFGLESTAGEIPVVAIR
LAPEYEAAATR LNFAVASR LSKDPNIVIAK MDATANDVPSPYEVR QAGPASVPLR RLAPEYEAAATR SEPIPESNDGPVK TADGIVSHLKK TEEEFKK TFSHELSDFGLESTAGEIPVVAIR
Periplakin
PEPL_HUMAN PPL
204,660
100.00%
24
24
123
14-3-3 protein gamma
1433G_HUMAN YWHAG
28,285
100.00%
11
14
101
TVAYTEQK VVVAENFDEIVNNENK YGVSGYPTLK 15.20% AGLIDWNMFVK AITGILRPPLEQGR ALEQETR ASQEEQIAR AVQDSAER EAEVLLLQQR ELDEETER ELSELIEQLQK EVDPQVNWAALVEEK FTEVYAINR GAEEQLR KVPDPVLEESFQQLQR LAALEQEEAEAR LELVEQER LLAASQAR LQNLEFALNLLR NLLDEIASR SLLGEVEQNLQAAK SSLEEESR STAEGEAFIQALPGSGTTPLLR TENPGDASDLQGR VKEEEAALAAK VLDKYEDVVQGLQK VVLQQDPQQAR 59.90% ATVVESSEK AYSEAHEISK DNLTLWTSDQQDDDGGEGNN DSTLIMQLLR LAEQAER LAEQAERYDDMAAAMK MKGDYYR NCSETQYESK NLLSVAYK NLLSVAYKNVVGAR NVTELNEPLSNEER
95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
80.0 30.2 54.3 97.0 57.6 68.8 87.5 50.8 51.7 57.8 44.4 30.7 99.2 50.9 129.0 56.8 46.3 41.9 41.8 46.8 42.8 63.7 30.6 68.0 83.2 49.2 46.5 30.5 73.8 32.0 41.2 78.8 43.9 85.9 52.6 69.8 64.2 27.8 83.5 52.6 58.0 55.2 80.8 79.3 59.4 52.0 42.7 42.2 51.4 79.1 94.6
22.5 22.9 20.3 23.5 22.6 16.6 20.8 18.9 23.2 21.9 18.8 21.9 21.5 21.9 22.6 21.9 23.4 15.1 22.4 22.2 22.0 21.1 18.3 21.7 22.4 21.9 22.0 20.5 22.9 22.4 22.2 17.6 23.6 21.5 20.6 20.4 19.6 23.5 21.4 21.2 23.5 22.8 12.8 21.3 21.6 20.8 19.2 14.3 19.1 17.7 21.6
5 1 0 24 34 5 24 4 2 10 2 1 2 5 7 33 2 2 3 4 1 6 1 9 4 8 2 0 1 1 3 2 9 19 2 10 21 0 2 8 5 6 4 113 36 4 6 2 49 4 23
12 0 10 0 0 18 0 0 1 0 1 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 2 0
0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,652.77 703.36 2,703.40 1,191.60 877.49 1,197.72 1,680.75 995.56 1,347.70 1,368.66 1,168.67 910.45 2,575.30 939.48 1,832.90 1,084.57 1,293.67 1,520.89 846.43 1,031.51 875.42 1,198.68 1,020.45 1,329.73 1,726.87 1,112.57 802.41 1,913.01 1,329.67 1,015.54 829.49 1,443.83 1,030.55 1,499.81 936.43 2,216.16 1,359.61 1,158.64 1,633.88 1,281.69 949.48 1,134.54 2,193.88 1,189.66 816.42 1,812.83 932.43 1,245.51 907.53 1,503.86 1,643.79
Table S1 page 7/159
RATVVESSEK TAFDDAIAELDTLNEDSYK VISSIEQK YDDMAAAMK YLAEVATGEK YLAEVATGEKR ARPAEVGGMQLR GNVGVVLFNFGK IFYPEIEEVQALDDTER LSEHATAPTR ALQDLENAASGDATVR EFESVLVDAFSHVAR IASLPQEVQDVSLLEK LTFLYLANDVIQNSK SVYGGEFIQQLK IGGGIDVPVPR IGQQPQQPGAPPQQDYTK IQNDAGVR SVSLTGAPESVQK VQISPDSGGLPER ELSNTAAYQSVR FASYINNDMVLQK FFPFGLVQLSSDLSK QGSIPYDSVTGPSK AAEEPSKVEEK AEDGATPSPSNETPK EAGEGGEAEAPAAEGGK GEAAAERPGEAAVASSPSK GEPAAAAAPEAGASPVEK
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
DUT_HUMAN DUT
26,689
100.00%
4
5
13
20.20%
Regulation of nuclear pre-mRNA domain-containing protein 1B
RPR1B_HUMAN RPRD1B
36,883
100.00%
5
6
14
22.70%
Far upstream element-binding protein 2
FUBP2_HUMAN KHSRP
73,129
100.00%
4
4
11
8.87%
Sialate O-acetylesterase
SIAE_HUMAN SIAE
58,297
100.00%
4
4
11
10.30%
31,536
100.00%
6
7
32
25.30%
11,350
100.00%
6
8
42
274,595
100.00%
28
28
80
51.50% DAVTYTEHAK DNIQGITKPAIR ISGLIYEETR TVTAMDVVYALK TVTAMDVVYALKR VFLENVIR 16.00% AFEDEMSGR ALVADSHPESER DASVAEAWLLGQEPYLSSR DTGNIGQER EIEELQSQAQALSQEGK EQWANLEQLSAIR EVDDLEQWIAER FESLEPEMNNQASR FMELLEPLNER HQILEQAVEDYAETVHQLSK ITDLYTDLR IVSSSDVGHDEYSTQSLVK LAEISDVWEEMK LLEVLSGER LQALDTGWNELHK
Myristoylated alanine-rich C-kinase MARCS_HUMAN MARCKS substrate
TAAKGEAAAERPGEAAVASSPSK
Histone H4
H4_HUMAN
Spectrin beta chain, brain 1
SPTB2_HUMAN SPTBN1
HIST1H4A
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
40.3 121.0 65.9 70.3 64.8 64.8 37.6 79.5 106.0 47.8 89.5 54.2 88.5 73.0 69.4 60.3 66.6 35.0 63.8 49.6 61.6 34.5 98.2 54.1 36.3 55.1 76.0 90.9 93.4 39.2 35.1 50.4 41.5 56.5 79.4 52.8 40.9 42.9 72.2 52.8 98.2 57.8 64.0 47.0 51.5 49.1 31.9 41.3 36.0 48.8 55.7
23.5 20.4 22.9 14.5 22.1 22.3 22.2 20.9 21.6 21.8 22.3 22.9 19.5 20.1 21.1 18.6 22.3 21.3 23.2 22.1 22.2 22.2 21.7 22.8 22.5 20.8 19.3 22.1 22.9 21.7 22.8 18.8 22.5 20.8 20.0 20.3 14.0 22.4 21.8 20.2 21.9 22.5 20.8 18.3 22.5 22.2 22.3 22.8 21.9 21.5 22.6
2 12 27 11 19 8 0 2 2 3 2 1 2 2 3 3 2 2 4 2 2 1 6 2 0 11 2 4 6 0 3 2 6 4 2 21 2 2 1 2 2 2 5 4 2 0 1 0 1 4 2
0 2 0 0 0 2 1 0 0 5 0 4 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 6 0 1 0 2 0 0 2 0 0 0 0 0 0 0 0 0 0 2 0 4 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,105.59 2,130.97 903.52 1,015.42 1,080.56 1,236.66 1,300.68 1,250.69 2,066.99 1,082.56 1,630.80 1,705.85 1,768.97 1,738.94 1,368.72 1,079.62 1,980.98 872.46 1,302.69 1,354.70 1,338.67 1,558.76 1,684.90 1,435.71 1,216.61 1,500.68 1,529.67 1,784.88 1,622.80 2,156.09 1,134.54 1,325.75 1,180.62 1,310.70 1,466.80 989.58 1,057.43 1,310.63 2,092.04 989.47 1,887.93 1,557.80 1,502.71 1,667.73 1,406.70 2,338.17 1,109.58 2,050.99 1,465.69 1,015.58 1,524.78
Table S1 page 8/159
Serine-threonine kinase receptorassociated protein
STRAP_HUMAN STRAP
38,421
100.00%
5
5
8
Annexin A8
ANXA8_HUMAN ANXA8
36,865
100.00%
18
22
225
LQQFLR LVSDGNINSDR LVSQDNFGFDLPAVEAATK MLTAQDMSYDEAR QALQDTLALYK SQNIVTDSSSLSAEAIR TALPAQSAATLPAR TQETPSAQMEGFLNR TQTAIASEDMPNTLTEAEK VAVVNQIAR VDSIDDR VIESTQDLGNDLAGVMALQR VLDNAIETEK VLVLSQDYGK 21.70% FSPDGELYASGSEDGTLR IYDLNKPEAEPK QGDTGDWIGTFLGHK TVDFTQDSNYLLTGGQDK YDYNSGEELESYK 66.40% AYEEDYGSSLEEDIQADTSGYLER CTQNLHSYFAER DDVSSFVDPGLALQDAQDLYAAGEK
Protein transport protein Sec23A
SC23A_HUMAN SEC23A
86,145
100.00%
3
3
12
5.62%
Destrin
DEST_HUMAN DSTN
18,488
99.50%
2
2
4
18.80%
Transmembrane protein 132A
T132A_HUMAN TMEM132A
110,089
100.00%
7
7
20
9.48%
Interstitial collagenase
MMP1_HUMAN MMP1
53,990
100.00%
13
13
96
27.10%
EGVIIEILASR FITILCTR GIGTNEQAIIDVLTK GIGTNEQAIIDVLTKR ILVCLLQGSR LIVALMYPPYR NALLSLVGSDP SATHLLR SEIDLNLIK SELSGKFER SETHGSLEEAMLTVVK SSSHFNPDPDAETLYK SWIEQEGVTVK TKNQLR TLSSMIMEDTSGDYK GPQVQQPPPSNR HLLQAPVDDAQEILHSR IDMNLTDLLGELQR HECQANGPEDLNR MIYASSK YALYDASFETK AEELVNTAPLTGVPQHVPVR EPGVTSIEVR IELTDTTLEQVR QVAGSVGGNTGVR SETFLLLQPWPR VASLEGGR VPGPAEGPAEPAAEASDEAERR ADVDHAIEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
31.1 74.3 92.1 31.2 50.6 118.0 57.0 56.3 129.0 53.0 43.6 104.0 50.6 43.0 66.2 30.0 49.8 107.0 70.8 33.7 48.5 92.5 87.1 66.6 105.0 104.0 77.7 64.5 35.3 32.1 58.1 34.5 73.3 68.7 55.7 31.5 106.0 62.3 60.0 61.3 54.6 37.6 59.8 37.1 45.4 55.1 41.4 45.4 41.4 37.9 31.3
21.2 23.2 22.1 14.3 21.4 22.8 18.8 22.0 21.4 16.0 22.5 21.9 24.2 22.0 18.7 21.7 22.6 21.7 15.1 16.5 20.8 20.9 20.8 20.8 20.6 18.3 21.2 20.6 22.9 18.7 21.7 21.8 21.7 21.8 22.5 22.7 19.3 23.7 21.5 22.3 17.7 20.3 22.6 18.0 22.7 22.8 22.4 21.5 24.3 21.6 21.0
5 3 4 2 2 4 5 1 6 3 2 2 6 4 1 1 0 2 2 1 2 6 59 11 24 4 6 20 1 1 7 2 13 5 6 1 16 8 0 2 2 1 2 0 4 4 2 2 2 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 2 4 0 0 0 0 0 0 0 0 0 0 31 3 0 0 0 0 2 0 0 0 0 4 0 0 0 0 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
804.47 1,189.58 2,022.02 1,562.65 1,263.70 1,777.89 1,367.76 1,708.80 2,065.96 969.58 819.39 2,146.08 1,131.59 1,121.62 1,900.86 1,416.74 1,631.78 2,001.94 1,596.67 2,740.18 1,525.69 2,624.24 1,199.70 1,023.57 1,571.86 1,727.97 1,158.67 1,335.75 1,085.58 797.46 1,044.59 1,052.54 1,730.86 1,807.81 1,275.66 759.45 1,693.73 1,304.67 1,942.01 1,630.85 1,539.66 815.40 1,307.62 2,127.16 1,086.58 1,417.75 1,201.63 1,486.81 788.43 2,206.04 997.50
Table S1 page 9/159
Myosin regulatory light chain 12A
ML12A_HUMAN MYL12A
19,777
100.00%
5
6
12
39.80%
ATP-dependent DNA helicase Q1
RECQ1_HUMAN RECQL
73,441
100.00%
2
2
4
3.85%
ADP-ribosylation factor 1
ARF1_HUMAN ARF1
20,680
100.00%
3
3
6
25.40%
Beta-mannosidase
MANBA_HUMAN MANBA
100,879
100.00%
13
13
46
18.30%
Low-density lipoprotein receptor
LDLR_HUMAN LDLR
95,357
100.00%
4
4
11
5.35%
Plasminogen activator inhibitor 1 RNA-binding protein
PAIRB_HUMAN SERBP1
44,948
100.00%
4
4
30
13.70%
18,630
99.50%
2
2
4
20.30%
Cold-inducible RNA-binding protein CIRBP_HUMAN CIRBP Protein S100-A9
S10A9_HUMAN S100A9
13,224
99.90%
2
2
2
18.40%
Syndecan-4
SDC4_HUMAN SDC4
21,624
100.00%
6
8
435
25.30%
AFQLWSNVTPLTFTK DIYSSFGFPR EYNLHR HIDAALSEENTGK IENYTPDLPR NSGPVVEK QMQEFFGLK SMDPGYPK SQNPVQPIGPQTPK TYFFVANK VTGKPDAETLK YDEYKR ATSNVFAMFDQSQIQEFK DGFIDKEDLHDMLASLGK FTDEEVDELYR GNFNYIEFTR LNGTDPEDVIR ISSMVVMENVGQQK VAGVVAPTLPR ILMVGLDAAGK LGEIVTTIPTIGFNVETVEYK NISFTVWDVGGQDK FASEYGYQSWPSFSTLEK FQSAVLYAAQQSK FSDNGFLMTEK GSNWIPADSFQDR GSPGLSFYFK ILFNEVTIGETDNMFNR LLLQSVVDANMNTLR TILFYPWEPTSK TVELIEEPIK VNLILEGVDTVSK VSSTEDWSFNSK VTSELLR YSFDITNVVR AHGVSSYDTVISR IYWSDLSQR NVVALDTEVASNR SEYTSLIPNLR EAGGGGVGGPGAK FDQLFDDESDPFEVLK RPDQQLQGEGK SAAQAAAQTNSNAAGK GFGFVTFENIDDAK LFVGGLSFDTNEQSLEQVFSK MSQLER NIETIINTFHQYSVK AGSGSQVPTEPK AGSGSQVPTEPKK ETEVIDPQDLLEGR ISPVEESEDVSNK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
78.7 67.5 33.6 82.8 50.8 36.8 33.9 34.2 78.8 38.3 42.5 34.7 101.0 70.1 72.9 67.0 60.9 44.7 52.0 44.1 57.3 77.2 94.2 109.0 69.9 34.3 37.8 107.0 79.6 34.2 55.9 99.4 72.5 33.9 72.1 45.0 30.3 89.7 51.8 78.6 97.2 55.5 91.7 55.2 123.0 35.5 47.7 77.2 39.5 89.2 101.0
20.1 21.3 21.0 22.5 23.0 21.0 21.0 18.5 21.8 23.1 23.4 19.6 21.5 22.1 19.4 21.7 22.8 22.9 14.8 23.1 18.5 23.3 21.2 22.1 19.5 21.0 23.1 22.1 21.0 23.1 20.8 19.5 20.1 22.3 21.4 23.3 22.4 22.1 23.0 21.0 20.3 22.1 22.9 21.5 22.0 24.1 21.5 22.3 22.0 22.5 22.0
9 18 2 15 7 1 4 1 26 5 5 2 4 2 2 2 1 1 3 2 2 2 3 6 3 1 3 3 7 1 5 5 4 1 4 1 1 3 6 4 8 8 10 2 2 1 1 99 3 134 33
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,752.93 1,188.57 831.41 1,384.67 1,217.62 829.44 1,127.56 910.40 1,490.80 989.51 1,158.64 873.41 2,090.99 2,003.98 1,415.63 1,260.60 1,228.62 1,581.76 1,079.66 1,087.62 2,323.24 1,565.76 2,126.97 1,440.75 1,288.59 1,492.68 1,102.56 2,028.97 1,702.92 1,481.77 1,170.66 1,386.78 1,386.62 817.48 1,213.62 1,391.69 1,167.58 1,387.72 1,292.69 1,013.50 1,943.89 1,255.64 1,460.71 1,559.74 2,345.17 763.38 1,806.94 1,157.58 1,285.68 1,613.80 1,432.68
Table S1 page 10/159
Protein transport protein Sec24C
SC24C_HUMAN SEC24C
118,307
100.00%
2
2
2
Transketolase
TKT_HUMAN TKT
67,861
100.00%
29
39
526
KLEENEVIPK RISPVEESEDVSNK 3.02% AVITSLLDQIPEMFADTR TLFQPQTGAYQTLAK 50.70% AFDQIR AVELAANTK AYGQALAK DAIAQAVR HQPTAIIAK IIALDGDTK ILATPPQEDAPSVDIANIR ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR
ISSDLDGHPVPK KAYGQALAK KILATPPQEDAPSVDIANIR KISSDLDGHPVPK KLILDSAR LDNLVAILDINR LGHASDR LGQSDPAPLQHQMDIYQK LQALKDTANR MFGIDRDAIAQAVR MPSLPSYK NMAEQIIQEIYSQIQSK NSTFSEIFK NSTFSEIFKK QAFTDVATGSLGQGLGAACGMAYTGK
Splicing factor, arginine/serine-rich 9 SFRS9_HUMAN SFRS9
25,525
100.00%
4
5
9
Cathepsin S
CATS_HUMAN CTSS
37,478
99.50%
2
2
4
Integrin alpha-6
ITA6_HUMAN ITGA6
126,618
100.00%
8
8
36
SGKPAELLK SVPTSTVFYPSDGVATEK TSRPENAIIYNNNEDFQVGQAK TVPFCSTFAAFFTR VLDPFTIKPLDR VLDPFTIKPLDRK 21.30% DGVGMVEYLR EKDLEDLFYK IYVGNLPTDVR VLVSGLPPSGSWQDLK 6.04% GIDSDASYPYK ILPDSVDWR 9.91% LETTSNQDNLAPITAK LIATFPDTLTYSAYR LLLVGAPR LNYLDILMR NIGDINQDGYPDIAVGAPYDDLGK
Prostaglandin F2 receptor negative regulator
FPRP_HUMAN PTGFRN
98,538
100.00%
15
15
47
SEDEVGSLIEYEFR SRPVINIQK VNSLPEVLPILNSDEPK 17.50% ALSADQGSYR AQDGDFIFSK EGEPFELR EHTDTFNFR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
57.7 78.5 55.9 35.7 35.9 55.9 42.9 37.0 37.1 49.7 99.8 86.0 55.6 51.4 54.1 83.2 53.6 86.8 31.3 76.0 38.6 57.1 43.0 113.0 38.8 44.5 91.2 46.1 94.8 84.7 64.8 62.8 27.9 57.9 60.4 50.9 50.8 45.5 30.5 82.8 73.0 34.5 73.7 90.2 66.7 34.9 56.5 62.2 40.9 36.5 35.3
21.6 23.1 21.6 20.7 25.6 23.0 22.7 22.7 17.4 23.1 20.1 18.9 22.7 20.5 17.8 20.7 19.8 17.6 21.3 22.1 21.6 22.8 21.8 21.7 20.6 22.6 21.0 19.6 22.3 21.6 22.1 19.2 14.9 22.6 21.9 22.0 20.0 20.9 23.5 21.9 21.5 12.6 21.7 21.5 21.0 16.1 19.6 22.1 21.4 22.3 20.3
78 33 1 1 8 4 3 1 3 10 68 0 9 3 0 3 7 21 1 8 1 2 5 28 2 7 4 1 60 6 6 20 0 1 3 2 2 2 2 3 8 1 9 2 2 3 8 2 4 1 1
29 26 0 0 0 0 0 0 0 0 30 2 11 0 2 4 0 0 0 11 0 11 0 57 0 0 2 0 0 71 0 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,198.67 1,588.78 2,036.04 1,666.88 749.39 916.51 821.45 843.47 978.57 945.53 2,020.07 3,752.91 1,264.65 949.55 2,148.17 1,392.75 915.56 1,368.79 755.38 2,069.01 1,129.63 1,562.81 938.47 2,039.01 1,072.53 1,200.63 2,532.19 942.56 1,884.92 2,508.21 1,651.79 1,413.81 1,541.91 1,138.56 1,299.65 1,246.68 1,682.91 1,215.55 1,100.57 1,715.88 1,731.90 838.55 1,150.63 2,520.19 1,672.77 1,054.64 1,864.01 1,067.51 1,127.54 976.47 1,166.52
Table S1 page 11/159
26,580
100.00%
6
8
31
CNDP2_HUMAN CNDP2
52,862
100.00%
12
14
40
Aspartate aminotransferase, cytoplasmic
AATC_HUMAN GOT1
46,230
100.00%
14
17
85
Ubiquitin-like modifier-activating enzyme 1
UBA1_HUMAN UBA1
117,832
100.00%
20
24
171
Eukaryotic translation initiation factor 6
IF6_HUMAN
Cytosolic non-specific dipeptidase
EIF6
GEILLR LDTVGSDAYR MDVLNAFK MPDSTLPGSR MYQTQVSDAGLYR NVQPSDQGHYK SDLSLER TANDAVELHIK VLADSLHVGPSARPPPSLSLR VPTATLVR YIISLDQDSVVK 37.10% ASFENNCEIGCFAK ETEEILADVLK HGLLVPNNTTDQELQHIR LNEAQPSTIATSMR NSLPDTVQIR TSIEDQDELSSLLQVPLVAGTVNR
38.10% EGGSIPVTLTFQEATGK GNILIPGINEAVAAVTEEEHK GSTDDKGPVAGWINALEAYQK LPDGSEIPLPPILLGR LVPNMTPEVVGEQVTSYLTK NVMLLPVGSADDGAHSQNEK QKLPDGSEIPLPPILLGR QLGGSVELVDIGK TVFGVEPDLTR WVAIQSVSAWPEK YIDENQDR YPSLSLHGIEGAFSGSGAK 42.90% APPSVFAEVPQAQPVLVFK EPESILQVLSQMEK HIYLLPSGR IANDNSLNHEYLPILGLAEFR IGADFLAR INVSGLTTK ITWSNPPAQGAR IVASTLSNPELFEEWTGNVK KVNLGVGAYR LALGDDSPALK NFGLYNER NLDYVATSIHEAVTK QIASVMK VGGVQSLGGTGALR 26.50% AAVATFLQSVQVPEFTPK AENYDIPSADR AEVSQPR ALPAVQQNNLDEDLIR ALPAVQQNNLDEDLIRK ATLPSPDKLPGFK GNVQVVIPFLTESYSSSQDPPEK IYDDDFFQNLDGVANALDNVDAR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
32.3 62.8 50.7 56.4 102.0 32.8 46.8 33.1 51.5 36.9 44.7 52.3 59.7 67.8 72.1 35.5 73.3 83.1 45.9 29.3 56.4 81.5 90.0 47.3 87.9 48.0 77.1 42.8 36.4 87.1 73.5 33.6 29.8 65.7 35.8 68.0 102.0 33.9 47.6 30.6 83.2 32.1 76.6 73.1 44.4 31.7 95.9 50.8 31.8 75.7 53.6
22.0 21.7 22.8 21.8 20.6 20.9 24.7 22.4 15.4 18.9 22.1 15.8 22.1 20.6 23.1 22.4 19.0 22.7 20.9 22.4 13.4 21.5 21.8 13.0 22.4 22.9 22.7 20.1 21.7 17.8 22.2 18.8 20.8 24.4 20.4 22.3 21.2 17.9 21.9 21.4 21.4 22.6 22.2 19.3 21.2 20.5 22.0 19.2 20.1 21.8 19.7
1 8 2 9 5 1 4 0 0 3 2 2 2 0 6 1 8 4 2 0 4 4 3 3 3 4 2 1 0 10 14 2 0 9 3 10 9 0 4 1 4 1 6 20 3 2 6 1 1 4 4
0 0 0 0 0 0 0 2 2 0 0 0 0 3 0 0 7 0 0 1 0 0 3 5 0 0 0 0 1 3 0 0 5 0 0 0 1 1 0 0 2 0 0 2 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
700.44 1,096.53 937.48 1,060.51 1,531.72 1,272.60 819.42 1,210.64 2,169.21 856.53 1,379.74 1,646.69 1,259.67 2,085.08 1,534.75 1,142.62 2,584.35 1,734.89 2,204.16 2,220.09 1,686.98 2,221.14 2,097.99 1,943.13 1,314.73 1,233.65 1,500.79 1,052.47 1,877.94 2,024.12 1,630.84 1,055.60 2,399.24 862.48 932.54 1,297.67 2,234.13 1,076.62 1,099.60 1,012.49 1,660.85 792.43 1,271.71 1,933.04 1,250.57 786.41 1,808.95 1,937.05 1,370.77 2,521.25 2,600.19
Table S1 page 12/159
LAGTQPLEVLEAVQR LAYVAAGDLAPINAFIGGLAAQEVMK
Proteasome subunit beta type-5
PSB5_HUMAN PSMB5
28,463
100.00%
9
12
69
Golgi apparatus protein 1
GSLG1_HUMAN GLG1
134,536
100.00%
3
3
5
Coactosin-like protein
COTL1_HUMAN COTL1
15,927
100.00%
11
12
40
Aspartate aminotransferase, mitochondrial
AATM_HUMAN GOT2
47,459
100.00%
11
12
78
LDQPMTEIVSR LKSDTAAAAVR LQTSSVLVSGLR LVVADTR NEEDAAELVALAQAVNAR NFPNAIEHTLQWAR QPAENVNQYLTDPK SLVASLAEPDFVVTDFAK VGPDTER YDGQVAVFGSDLQEK 31.20% ATAGAYIASQTVK ATAGAYIASQTVKK DAYSGGAVNLYHVR GPGLYYVDSEGNR HGVIVAADSR ISVAAASK LLANMVYQYK RGPGLYYVDSEGNR VSSDNVADLHEK 2.97% FCENTQAGEGR IIIQESALDYR VAELSSDDFHLDR 70.40% AGGANYDAQTE ELEEDFIK ELEEDFIKSELK EVVQNFAK FALITWIGENVSGLQR FTTGDAMSK FTTGDAMSKR KAGGANYDAQTE LFAFVR TGTDKTLVK YDGSTIVPGEQGAEYQHFIQQCTDDVR
28.80% ASAELALGENSEVLK DAGMQLQGYR EIATVVK FVTVQTISGTGALR IAAAILNTPDLR IAAAILNTPDLRK IGASFLQR ISVAGVTSSNVGYLAHAIHQVTK
Nascent polypeptide-associated complex subunit alpha
NACA_HUMAN NACA
23,365
100.00%
6
6
44
MNLGVGAYR NLDKEYLPIGGLAEFCK NMGLYGER 30.70% IEDLSQQAQLAAAEK NILFVITKPDVYK NNSNDIVNAIMELTM QVTGVTR SKNILFVITKPDVYK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
92.1 42.4 61.0 63.2 81.7 35.2 110.0 55.8 76.0 93.3 53.2 97.5 110.0 83.7 72.1 71.3 56.1 34.9 67.5 67.8 84.0 49.2 66.4 36.9 52.1 38.4 58.2 33.7 81.7 39.2 46.6 36.2 34.8 41.8 39.1 59.8 76.5 40.3 107.0 74.9 49.8 70.4 24.3 34.1 30.4 46.1 128.0 77.0 40.6 35.5 40.7
17.9 18.7 23.5 21.1 19.1 24.6 21.8 22.3 22.6 22.0 20.1 21.6 21.0 19.3 23.2 21.4 21.2 22.4 21.2 22.4 22.5 17.0 22.0 21.0 17.0 22.8 22.8 23.4 20.8 17.2 21.6 20.1 16.3 19.1 17.3 22.6 21.2 22.8 20.9 18.0 15.9 21.7 17.8 23.3 22.0 20.5 22.3 15.8 20.3 24.2 13.4
23 0 12 4 10 1 14 1 8 19 3 7 13 2 7 4 17 1 9 2 8 1 2 0 2 3 2 2 14 2 2 1 8 1 0 8 10 2 35 8 3 4 0 1 0 4 14 10 3 1 0
9 4 0 4 0 0 9 0 0 0 0 0 0 0 2 0 0 0 0 1 3 0 0 2 0 0 0 0 1 0 0 0 0 0 2 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,623.91 2,619.39 1,304.65 1,102.62 1,259.73 773.45 1,883.95 1,696.86 1,616.79 1,909.00 773.38 1,655.79 1,280.69 1,408.78 1,521.75 1,426.66 1,024.55 746.44 1,242.66 1,582.76 1,313.63 1,268.53 1,320.72 1,503.71 1,096.45 1,022.50 1,479.76 934.50 1,803.98 973.43 1,113.54 1,224.55 752.45 962.55 3,113.39 1,530.80 1,138.53 759.46 1,449.81 1,267.74 1,395.83 891.51 2,352.27 980.50 1,967.00 955.43 1,614.83 1,549.90 1,710.77 760.43 1,765.03
Table S1 page 13/159
Coatomer subunit beta'
COPB2_HUMAN COPB2
102,471
100.00%
3
3
10
G-protein coupled receptor 126
GP126_HUMAN GPR126
136,681
99.50%
2
2
19
Prefoldin subunit 2
PFD2_HUMAN PFDN2
16,630
99.50%
2
2
3
26S proteasome non-ATPase regulatory subunit 7 Poly(ADP-ribose) glycohydrolase ARH3
PSD7_HUMAN PSMD7
37,008
99.50%
2
2
4
ARHL2_HUMAN ADPRHL2
38,929
100.00%
3
3
8
MAT2B_HUMAN MAT2B
37,534
100.00%
6
7
20
Methionine adenosyltransferase 2 subunit beta
SPASDTYIVFGEAK 4.53% AAESLADPTEYENLFPGLK LPEAAFLAR NVMEEGKDFQPSR 2.46% LLLGSNQNEIVSLK VILPQTSDAYQVSVAK 16.90% GAVSAEQVIAGFNR IIETLTQQLQAK 7.72% DIKDTTVGTLSQR SVVALHNLINNK 10.70% ALVQSLLAK HVQSLEPDPGTPGSER TEALYYTDDTAMAR 24.30% AVLENNLGAAVLR IPILYGEVEK LETLGIGQR LVEEEVNIPNRR RPDVVENQPDAASQLNVDASGNLAK
VLVTGATGLLGR Brain acid soluble protein 1
BASP1_HUMAN BASP1
22,675
100.00%
6
7
20
50.70%
AAEAAAAPAESAAPAAGEEPSKEEGEPK
AEPPKAPEQEQAAPGPAAGGEAPK
ESEPQAAAEPAEAK ETPAATEAPSSTPK KTEAPAAPAAQETK SDGAPASDSKPGSSEAAPSSK Calcyclin-binding protein
CYBP_HUMAN CACYBP
26,192
100.00%
2
2
2
Proteasome subunit alpha type-6
PSA6_HUMAN PSMA6
27,382
100.00%
8
10
75
26S proteasome non-ATPase regulatory subunit 2
PSMD2_HUMAN PSMD2
100,184
100.00%
6
6
14
Lactadherin
MFGM_HUMAN MFGE8
43,105
100.00%
3
3
6
Myotrophin
MTPN_HUMAN MTPN
12,877
100.00%
2
2
4
Probable ATP-dependent RNA helicase DDX6 Ubiquitin thioesterase OTUB1
DDX6_HUMAN DDX6
54,401
99.50%
2
2
6
OTUB1_HUMAN OTUB1
31,267
100.00%
5
5
13
19.30% KAELLDNEKPAAVVAPITTGYTVK SYSMIVNNLLKPISVEGSSK 37.40% AINQGGLTSVAVR GSSAGFDR HITIFSPEGR ILTEAEIDAHLVALAERD LLDSSTVTHLFK LYQVEYAFK QTESTSFLEK YGYEIPVDMLCK 9.69% APVQPQQSPAAAPGGTDEKPSGK AVPLALALISVSNPR EDVLTLLLPVMGDSK FGGSGSQVDSAR HLAGEVAK VGQAVDVVGQAGKPK 10.90% EVTGIITQGAR MWVTGVVTQGASR NAVHVNLFETPVEAQYVR 25.40% GPDGLTAFEATDNQAIK NGDLDEVKDYVAK 7.25% GPVKPTGGPGGGGTQTQQQMNQLK SGAYLIPLLER 23.60% EYAEDDNIYQQK FFEHFIEGGR GEGGTTNPHIFPEGSEPK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
107.0 78.6 64.0 37.0 87.7 71.2 68.6 43.9 50.7 62.6 56.7 52.2 83.8 90.4 36.8 65.2 42.4 64.6 85.1 35.6 46.4 54.5 41.3 66.8 50.1 33.1 28.3 96.8 46.3 60.8 123.0 73.4 54.5 45.3 50.6 56.1 33.1 63.4 79.8 37.7 84.5 83.5 46.0 27.4 103.0 49.4 64.6 40.5 68.4 41.0 38.3
22.5 22.0 22.5 20.9 17.9 20.5 22.9 18.5 22.1 18.9 15.3 23.4 18.9 19.1 21.0 22.0 21.0 22.0 16.0 20.5 21.8 20.0 21.7 21.7 21.2 14.9 20.1 20.8 18.3 21.5 20.1 21.6 23.7 22.4 20.6 21.6 12.0 20.9 21.6 18.9 18.1 23.1 22.5 21.5 22.9 22.7 22.0 19.2 18.7 22.3 21.5
14 6 3 1 8 11 2 1 2 2 4 2 2 3 1 4 2 0 6 0 0 4 4 3 3 0 0 20 2 12 6 10 10 4 4 0 0 3 2 1 3 4 1 0 2 2 0 2 4 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 2 2 0 0 0 2 1 1 0 0 0 2 5 0 0 0 4 1 0 0 0 0 0 0 1 0 0 4 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,484.73 2,065.01 987.56 1,552.71 1,527.87 1,718.93 1,418.74 1,385.80 1,433.76 1,321.76 942.60 1,705.81 1,636.72 1,339.77 1,160.66 986.56 1,467.79 2,608.30 1,156.71 2,636.23 2,298.14 1,427.67 1,386.68 1,412.74 1,932.88 2,528.40 2,182.14 1,285.72 796.36 1,156.61 1,979.05 1,360.75 1,160.60 1,169.57 1,503.69 2,218.11 1,520.92 1,629.88 1,167.54 824.46 1,452.82 1,144.63 1,407.71 2,086.07 1,747.85 1,465.72 2,382.18 1,231.71 1,515.66 1,238.60 1,853.87
Table S1 page 14/159
Integrin beta-4
ITB4_HUMAN ITGB4
202,133
100.00%
9
9
38
60S ribosomal protein L10a
RL10A_HUMAN RPL10A
24,814
100.00%
8
11
26
Clusterin
CLUS_HUMAN CLU
52,477
100.00%
14
17
904
ATP-citrate synthase
ACLY_HUMAN ACLY
120,825
100.00%
13
13
23
75,373
99.90%
2
2
4
52,145
100.00%
3
3
14
IQQEIAVQNPLVSER LLTSGYLQR 5.98% DVVSFEQPEFSVSR EAIINLATQPK LLELQEVDSLLR LVFSALGPTSLR MLLIENLR NVISLTEDVDEFR QEVEENLNEVYR TQDYPSVPTLVR VAPGYYTLTADQDAR 27.60% AGKFPSLLTHNENMVAK AVDIPHMDIEALK AVDIPHMDIEALKK DTLYEAVR FPSLLTHNENMVAK KYDAFLASESLIK STMGKPQR YDAFLASESLIK 30.30% ALQEYR ASSIIDELFQDR ELDESLQVAER FMETVAEK IDSLLENDR KTLLSNLEEAK KYNELLK LFDSDPITVTVPVEVSR QQTHMLDVMQDHFSR RPHFFFPK SGSGLVGR TLLSNLEEAK TLLSNLEEAKK VTTVASHTSDSDVPSGVTEVVVK
N-acetylgalactosaminyltransferase 7 GALT7_HUMAN GALNT7 Ras GTPase-activating proteinbinding protein 1
G3BP1_HUMAN G3BP1
15.10% AFDSGIIPMEFVNK DLVSSLTSGLLTIGDR EAYPEEAYIADLDAK FICTTSAIQNR IGNTGGMLDNILASK LGQEATVGK LYRPGSVAYVSR QHFPATPLLDYALEVEK SGGMSNELNNIISR SINNPDMR TIAIIAEGIPEALTR TILSLMTR WGDIEFPPPFGR 5.02% LEGWQGNPPPIYVGSSPTLK SPAMAGGLFAIER 9.87% EAGEQGDIEPR LPNFGFVVFDDSEPVQK SSSPAPADIAQTVQEDLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
108.0 44.2 62.7 72.8 70.7 46.1 37.7 40.6 64.9 31.8 110.0 36.3 27.0 42.4 52.1 49.5 70.5 30.7 72.0 45.8 105.0 65.7 57.8 53.6 47.9 43.6 102.0 43.0 35.2 85.3 71.8 52.6 84.9 47.2 58.7 59.5 39.8 90.9 54.2 28.5 27.2 58.6 39.1 73.2 34.4 30.4 67.1 73.2 42.3 80.2 92.7
20.4 19.2 22.3 19.4 20.4 18.1 22.8 22.3 22.1 22.2 22.6 20.8 22.6 20.7 22.5 22.9 21.2 24.1 21.5 24.6 23.5 22.5 19.0 22.9 20.4 19.1 21.7 19.9 23.9 23.2 23.1 20.4 21.6 23.0 20.8 21.0 22.8 22.1 23.9 20.7 21.2 21.5 20.6 17.0 21.4 22.5 20.9 23.0 20.8 22.1 22.0
4 2 4 9 4 4 5 2 2 3 5 0 0 2 6 2 3 1 2 2 188 242 83 26 3 28 88 0 0 21 30 11 34 2 2 1 1 4 2 0 0 2 1 3 1 1 2 2 3 6 5
0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 5 0 0 0 0 0 0 0 1 0 0 9 57 0 0 0 64 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,723.93 1,050.59 1,625.78 1,197.68 1,427.81 1,260.73 1,001.58 1,536.75 1,521.72 1,375.72 1,640.79 1,856.97 1,451.76 1,595.85 966.49 1,616.81 1,484.80 904.47 1,356.71 779.41 1,393.70 1,288.64 970.46 1,074.54 1,245.71 907.53 1,873.99 1,872.85 1,075.58 732.40 1,117.61 1,245.71 2,314.18 1,567.78 1,646.90 1,697.79 1,310.65 1,503.78 902.49 1,367.74 1,971.02 1,507.72 962.44 1,567.91 934.54 1,417.69 2,140.11 1,335.67 1,200.55 1,937.97 1,884.93
Table S1 page 15/159
U1 small nuclear ribonucleoprotein A
SNRPA_HUMAN SNRPA
Dipeptidyl peptidase 1
CATC_HUMAN CTSC
51,824
100.00%
2
3
8
Dynactin subunit 2
DCTN2_HUMAN DCTN2
44,214
100.00%
4
4
7
Transferrin receptor protein 1
TFR1_HUMAN TFRC
84,856
100.00%
11
12
42
Involucrin
INVO_HUMAN IVL
68,457
100.00%
5
5
7
Glucosidase 2 subunit beta
GLU2B_HUMAN PRKCSH
59,408
100.00%
17
19
142
31,262
100.00%
4
4
10
17.00%
AVQGGGATPVVGAVQGPVPGMPPMTQAPR
EVSSATNALR GQAFVIFK KAVQGGGATPVVGAVQGPVPGMPPMTQAPR
4.10% AINAIQK NVHGINFVSPVR 12.70% ASVEDADTQSK LLGPDAAINLTDPDGALAK VAELEKR WSPIASTLPELVQR 17.00% AAAEVAGQFVIK DSAQNSVIIVDK GFVEPDHYVVVGAQR ILNIFGVIK LAQMFSDMVLK LLNENSYVPR SGVGTALLLK SSGLPNIPVQTISR VEYHFLSPYVSPK VSASPLLYTLIEK YNSQLLSFVR 12.00% HLEEQEGQLK HLEQQQGQLEVPEQQVGQPK HLVQQEGQLEQQER QEAQLELPEQQVGQPK YLEQQEGQLK 32.20% AQQEQELAADAFK ERESLQQMAEVTR ESLQQMAEVTR ETMVTSTTEPSR ILIEDWK ILIEDWKK LGGSPTSLGTWGSWIGPDHDK LGGSPTSLGTWGSWIGPDHDKFSAMK
Ras-related protein Rab-1A
RAB1A_HUMAN RAB1A
22,660
100.00%
5
5
15
Heterogeneous nuclear ribonucleoprotein K
HNRPK_HUMAN HNRNPK
50,961
100.00%
9
11
68
LIELQAGKK LVSQKPK LWEEQLAAAK NKFEEAER SEALPTDLPAPSAPDLTEPK SLEDQVEMLR SLKDMEESIR TVKEEAEKPER YEQGTGCWQGPNR 36.10% EFADSLGIPFLETSAK IQSTPVK LLLIGDSGVGK LQIWDTAGQER MGPGATAGGAEK NATNVEQSFMTMAAEIK 26.30% ENTQTTIK GSYGDLGGPIITTQVTIPK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
36.5 56.3 38.9 44.3 42.1 49.5 69.6 90.6 51.5 80.7 53.7 67.3 69.6 51.1 43.2 77.2 43.9 55.0 30.7 102.0 62.3 41.5 33.8 29.3 63.9 34.1 93.1 27.0 62.1 72.4 32.9 31.3 51.2 23.8 33.5 36.2 61.3 34.1 82.2 74.8 56.1 46.2 70.4 77.3 31.5 58.7 61.5 55.5 103.0 31.6 97.7
21.2 23.1 20.3 20.2 21.8 20.3 20.5 20.0 23.7 19.2 21.3 23.4 22.7 12.3 21.6 23.9 17.6 19.4 22.2 17.0 21.7 22.9 21.5 21.9 22.9 22.9 23.1 22.6 22.8 21.1 24.2 21.0 21.7 21.0 18.3 18.6 23.7 21.8 21.6 22.8 22.7 23.0 18.0 23.1 20.7 20.3 22.2 20.3 20.3 23.3 19.2
0 4 3 0 4 2 2 2 1 2 4 2 1 7 2 2 3 6 0 9 3 2 0 0 1 1 11 0 10 35 1 1 0 0 2 2 11 2 4 10 2 7 2 7 2 2 7 2 2 1 5
2 0 0 1 0 2 0 0 0 0 0 0 2 0 0 0 0 0 1 0 0 0 1 2 0 0 0 1 0 0 0 0 2 0 0 0 0 0 0 0 6 32 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,759.40 1,047.54 909.52 2,887.49 757.46 1,338.73 1,150.52 1,865.00 844.49 1,596.88 1,203.67 1,288.68 1,672.84 1,016.65 1,314.64 1,204.63 958.59 1,468.81 1,565.80 1,433.83 1,226.65 1,210.61 2,300.16 1,721.86 1,821.94 1,235.63 1,448.70 1,576.78 1,291.63 1,354.62 916.51 1,044.61 2,168.04 2,748.31 999.62 799.50 1,158.62 1,022.49 2,049.04 1,219.60 1,207.60 1,315.69 1,552.66 1,724.87 772.46 1,071.64 1,316.66 1,062.49 1,916.87 934.48 1,917.03
Table S1 page 16/159
Collagen alpha-1(XII) chain
COCA1_HUMAN COL12A1
333,127
100.00%
56
58
484
IDEPLEGSEDR IILDLISESPIK IITITGTQDQIQNAQYLLQNSVK NAGAVIGK RPAEDMEEEQAFKR TDYNASVSVPDSSGPER VVLIGGKPDR 24.50% ALALGALQNIR DITDTSIGAYWTSAPGMVR DYKPQVGVIADPSSK FNQMLNQIPNDYQSSR GDTTNTVLQGLK GEVQTVTFDTEEVK GGNTLTGMALNFIR GGNTMTGDAIDYLVK GMTSSEPISIMEK GPGDLEAPSNLVISER GQEITVR IEQELAAIK IIYRPVAGGESR IIYSPTVGDPIDEYTTVPGR ITEVTSEGFR ITVDPTTDGPTK ITWTQAPGR ITYQPSTGEGNEQTTTIGGR IVEVFDIGPK LGELVVGPYDNTVVLEELR LKPDTPYTITVSSLYPDGEGGR LLPETPSDPFAIWQITDR LNWNPSPSPVTGYK LQPQTTYDITVLPIYK LSPADGTR MIATDPDDTHAYNVADFESLSR NLQPDTSYTVTVVPVYTEGDGGR
NNVILQPLQPDTPYK NSDVEIFAVGVK NTFTESAGAR NVGVEVFSLGIK NVQVYNPTPNSLDVR QHALSVGPQTTTLSVR QVCEQLISGQMNR SLLQAVANLPYK SLYDDVDTGEK SQDDVEAPSKK SQDEVEIPAR TEFNLNQYYQR TLENLIPDTK TLKVDEETENTMR TSDPTMSSFR VEDIIEAINTFPYR VGVVQYSSDTR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
78.2 99.9 59.6 34.0 52.2 81.8 33.2 91.3 45.6 50.1 92.1 57.4 96.3 46.7 89.9 76.9 87.6 30.5 47.8 32.6 65.1 72.8 41.6 32.9 124.0 62.0 75.2 37.6 36.0 62.1 69.4 34.2 55.0 79.1 62.1 66.7 40.7 62.3 50.6 31.9 63.1 68.4 39.5 44.4 60.3 48.3 38.4 40.5 32.2 62.9 88.7
19.5 14.9 17.2 23.3 21.5 19.4 12.6 11.1 21.8 22.6 20.5 22.9 22.9 22.1 22.6 20.5 22.5 25.5 20.4 21.7 21.7 23.2 23.4 22.0 21.1 21.3 20.2 21.3 21.2 23.0 17.7 21.6 18.1 21.3 21.0 22.7 22.5 20.6 22.0 20.2 22.4 18.3 21.3 22.8 21.4 21.3 23.6 22.0 19.7 22.3 23.1
2 36 1 2 0 8 2 24 2 2 7 14 12 2 20 12 25 1 2 1 4 14 6 2 17 28 6 0 4 10 20 2 0 6 4 3 6 20 2 0 2 37 6 1 16 4 2 2 1 11 31
0 0 7 0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 6 0 0 0 0 3 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 6 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,259.58 1,340.80 2,589.39 729.43 1,751.80 1,780.80 1,053.64 1,139.69 2,056.97 1,603.83 1,954.91 1,246.66 1,581.77 1,464.76 1,570.74 1,441.66 1,653.85 802.44 1,014.58 1,317.73 2,193.11 1,138.57 1,244.64 1,029.55 2,110.01 1,116.63 2,115.13 2,366.19 2,099.08 1,559.79 1,893.04 816.42 2,484.10 2,468.19 1,739.93 1,277.67 1,053.50 1,261.72 1,715.87 1,694.92 1,562.74 1,316.76 1,241.55 1,203.59 1,143.56 1,475.69 1,143.63 1,581.74 1,144.49 1,679.86 1,210.61
Table S1 page 17/159
Dipeptidyl peptidase 3
DPP3_HUMAN DPP3
82,574
100.00%
12
14
69
VILTPMTAGSR VLVVVTDGR VPPTVTSTVLK VQIALAQYSGDPR VSDPTTSTMK VSWDPSPSPVLGYK VSWTPPSDSVDR VTDETTDSFK VTWEPAPGEVK VVYSPVDGTRPSESIVVPGNTR VYDPSTSTLNVR WDPAPGPVLQYR 23.50% AQDPDQLR EVDGEGKPYYEVR FPEDGPELEEILTQLATADAR FSTIASSYEECR GEFEGFVAVVNK LAQDFLDSQNLSAYNTR LASVLGSEPSLDSEVTSK NVSLGNVLAVAYATQR SGETWDSK VILGSEAAQQHPEEVR VLLEAGEGLVTITPTTGSDGRPDAR
Branched-chain-amino-acid aminotransferase, mitochondrial
BCAT2_HUMAN BCAT2
44,270
100.00%
6
6
14
Keratinocyte proline-rich protein
KPRP_HUMAN KPRP
64,115
100.00%
4
4
48
Granulins
GRN_HUMAN GRN
63,522
100.00%
16
20
423
Prostasin
PRSS8_HUMAN PRSS8
36,413
99.50%
2
2
4
VVEQLEK 21.20% AADLQLEMTQKPHK KPGPGEPLVFGK LFRPWLNMDR LGGNYGPTVLVQQEALK NLHIPTMENGPELILR QSLLDMAQTWGEFR 6.74% GRPAVCQPQGR IEISSPCCPR LQLFPR RLDQCPESPLQR 26.30% APAHLSLPDPQALK APAHLSLPDPQALKR ASLSHPR AVALSSSVMCPDAR CITPTGTHPLAK EVVSAQPATFLAR GSEIVAGLEK LPAHTVGDVK QGVCCADR QGWACCPYR QHCCPAGYTCNVK SCEKEVVSAQPATFLAR SPHVGVK VHCCPHGAFCDLVHTR WDAPLRDPALR WPTTLSR 6.12% LGAHQLDSYSEDAK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
33.3 58.0 34.9 82.7 49.5 69.6 33.0 64.2 33.2 42.5 80.8 53.7 34.1 51.4 33.3 69.1 48.4 125.0 65.7 117.0 60.8 90.8 70.2 40.9 37.5 43.7 26.9 70.2 42.6 88.7 41.6 37.3 35.0 52.8 57.7 64.5 58.1 81.5 58.6 87.5 66.4 53.1 46.8 44.3 51.9 43.4 39.2 20.5 28.9 32.6 36.3
22.7 20.0 18.1 22.5 21.6 23.2 21.2 20.0 21.3 20.4 22.6 22.0 20.5 22.7 21.5 18.4 22.1 21.5 22.7 20.0 20.0 21.7 19.8 20.9 22.2 19.2 23.5 19.5 21.2 21.8 22.6 20.1 23.2 21.6 20.4 18.8 20.6 21.7 21.7 22.3 22.8 20.0 14.9 15.8 15.8 22.0 17.8 18.3 21.6 24.1 22.0
1 8 2 6 6 13 2 10 1 0 12 2 1 4 0 4 2 10 8 8 3 4 0 3 1 2 0 2 0 5 0 1 3 1 11 8 43 25 15 99 77 22 1 8 6 0 10 0 0 2 0
0 0 0 0 0 0 0 0 0 8 0 0 0 2 1 0 0 0 0 0 0 4 15 0 0 0 1 0 3 0 43 0 0 0 5 51 0 0 4 0 0 0 0 0 0 3 0 0 3 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,145.64 957.57 1,141.68 1,417.74 1,082.50 1,531.78 1,345.64 1,142.52 1,212.63 2,329.22 1,351.69 1,398.72 942.46 1,540.73 2,315.14 1,449.63 1,295.66 1,955.95 1,818.93 1,675.91 909.40 1,762.91 2,525.32 844.48 1,625.83 1,225.69 1,363.69 1,786.97 1,862.98 1,681.80 1,225.62 1,218.56 773.47 1,498.74 1,457.81 1,613.91 767.42 1,479.69 1,295.68 1,388.75 1,002.55 1,036.58 965.39 1,197.49 1,594.66 1,892.95 723.42 1,965.86 1,309.70 860.46 1,533.72
Table S1 page 18/159
Polyadenylate-binding protein 1
PABP1_HUMAN PABPC1
70,653
100.00%
17
19
73
VTELQPR 29.90% ALDTMNFDVIK EFSPFGTITSAK FSPAGPILSIR GFGFVCFSSPEEATK GFGFVSFER IVATKPLYVALAQR KEFSPFGTITSAK NFGEDMDDER NFGEDMDDERLK NLDDGIDDERLR QAHLTNQYMQR QTELKR SGVGNIFIK SKVDEAVAVLQAHQAK SLGYAYVNFQQPADAER VANTSTQTMGPRPAAAAAAATPAVR
FACT complex subunit SSRP1
SSRP1_HUMAN SSRP1
Protein SET
SET_HUMAN
SET
81,060
99.90%
2
2
3
33,471
100.00%
8
12
148
YQGVNLYVK 2.68% ASSGLLYPLER LFDFVNAK 31.40% EFHLNESGDPSSK EQQEAIEHIDEVQNEIDR EQQEAIEHIDEVQNEIDRLNEQASEEILK
Poly(rC)-binding protein 1
PCBP1_HUMAN PCBP1
37,480
100.00%
2
2
12
Flavin reductase
BLVRB_HUMAN BLVRB
22,101
100.00%
5
6
28
HLA class I histocompatibility antigen, A-11 alpha chain
1A11_HUMAN HLA-A
40,919
100.00%
4
4
33
IDFYFDENPYFENK KPRPPPALGPEETSASAGLPK LNEQASEEILK LNEQASEEILKVEQK VEVTEFEDIK 9.27% ESTGAQVQVAGDMLPNSTER IITLTGPTNAIFK 42.70% LPSEGPRPAHVVVGDVLQAADVDK LQAVTDDHIR NDLSPTTVMSEGAR TVAGQDAVIVLLGTR YVAVMPPHIGDQPLTGAYTVTLDGR
CD109 antigen
18.40% APWIEQEGPEYWDQETR DGEDQTQDTELVETRPAGDGTFQK
CD109_HUMAN CD109
161,674
100.00%
33
41
575
SWTAADMAAQITK WAAVVVPSGEEQR 24.40% ADGNQLTLEER ADGNQLTLEERR AEQEGGMQFWVSSESK AKEALNMLTWR ALSEFAALMNTER AYFLGSK DYIDGVYDNAEYAER EALNMLTWR ELLYQR ELSYMVVSR FLIDTHNR GDVTLTFLPLSFWGK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
40.4 73.5 49.8 62.9 61.6 34.4 63.1 67.8 45.2 39.2 36.6 39.9 32.2 67.8 46.0 97.2 43.8 43.2 37.3 36.4 77.4 96.5 60.4 86.6 79.9 59.6 96.7 76.7 107.0 53.3 88.9 43.7 73.1 121.0 67.4 97.9 67.8 76.3 55.7 78.1 68.6 93.8 56.7 98.9 44.2 98.4 60.8 32.0 54.0 55.2 47.6
20.4 21.7 22.1 21.0 19.8 22.3 10.8 21.4 8.5 18.3 22.4 22.1 24.1 19.9 19.5 21.3 21.0 20.8 22.7 20.9 20.5 21.7 20.5 19.1 19.6 23.3 21.1 23.6 21.7 16.4 19.8 23.2 21.5 17.9 21.2 18.7 20.8 22.7 23.0 22.5 22.2 19.0 22.6 22.0 19.7 18.8 23.0 22.7 21.8 22.9 20.7
3 12 6 11 1 3 2 2 3 1 2 2 1 6 0 5 0 2 1 2 29 2 0 32 0 13 3 57 2 10 0 4 6 9 0 2 0 5 14 32 0 16 2 38 7 8 14 4 10 13 2
0 0 0 0 0 0 7 0 0 0 0 3 0 0 2 0 2 0 0 0 1 2 1 0 2 0 5 0 0 0 4 0 0 0 4 0 12 0 0 0 2 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
842.47 1,282.64 1,284.65 1,157.67 1,662.75 1,045.51 1,542.94 1,412.74 1,243.45 1,484.63 1,430.69 1,405.66 774.45 934.54 1,693.92 1,928.91 2,397.23 1,083.58 1,205.65 953.51 1,446.65 2,195.02 3,449.67 1,840.81 2,100.15 1,273.66 1,757.93 1,208.61 2,105.98 1,388.82 2,469.31 1,167.61 1,493.69 1,512.88 2,687.35 2,133.95 2,637.19 1,393.68 1,427.73 1,245.61 1,401.71 1,815.79 1,348.70 1,468.71 785.42 1,792.77 1,133.58 821.45 1,083.55 1,015.53 1,680.90
Table S1 page 19/159
Serine/threonine-protein phosphatase PTPA_HUMAN PPP2R4 2A activator
Heat shock cognate 71 kDa protein
HSP7C_HUMAN HSPA8
40,650
100.00%
6
7
19
70,882
100.00%
42
60
1243
IEFPILEDSSELQLK IPVQLVFK ISVFIQTDK ISVTQPDSIVGIVAVDK IVTLFSDFKPYK LKELSYMVVSR LSDSWQPR NNVVITVTQR NSLGGFASTQDTTVALK SNGEFWDPGR SNLIQQWLSQQSDLGVISK SSMAVHSLFK SYSQSILLDLTDNR TLSFSFPPNTVTGSER TLTLPSLPLNSADEIYELR TNIQVTVTGPSSPSPVK TRDENIK TYIQLK VGSPFELVVSGNK VGSPFELVVSGNKR VIHSELQGGNK 20.90% FGSLLPIHPVTSG FPVIQHFK LVALLNTLDR QPPPDSSEEAPPATQNFIIPK VDDQIAIVFK WIDETPPVDQPSR 61.00% ARFEELNADLFR ATVEDEK CNEIINWLDK DAGTIAGLNVLR EIAEAYLGK FDDAVVQSDMK FEELNADLFR FELTGIPPAPR GPAVGIDLGTTYSCVGVFQHGK GTLDPVEK HWPFMVVNDAGRPK IINEPTAAAIAYGLDK IINEPTAAAIAYGLDKK ITITNDKGR LDKSQIHDIVLVGGSTR LLQDFFNGK LSKEDIER MKEIAEAYLGK MVNHFIAEFK MVNHFIAEFKR MVQEAEK MVQEAEKYK NQTAEKEEFEHQQK NQVAMNPTNTVFDAK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
104.0 57.2 52.2 99.5 59.6 46.1 68.6 52.6 101.0 50.9 122.0 39.9 92.4 79.8 101.0 105.0 35.9 33.1 90.7 81.5 35.3 63.3 33.1 76.9 47.0 49.0 51.2 53.8 32.9 51.4 109.0 50.7 88.0 56.2 35.9 52.1 46.9 61.0 114.0 129.0 64.4 86.0 50.0 62.1 71.7 46.7 34.3 49.8 32.2 69.7 106.0
21.5 17.0 21.5 18.3 20.9 20.9 21.7 20.7 21.9 17.9 20.3 24.1 22.0 22.0 20.0 20.4 24.5 19.1 22.3 20.3 22.6 20.5 23.0 19.1 21.3 21.8 23.2 22.1 23.2 24.2 22.0 21.7 19.8 22.7 19.7 21.4 21.5 22.6 21.5 17.0 22.3 19.3 22.1 23.4 22.1 22.9 22.7 23.2 23.3 20.9 22.6
50 22 7 42 23 2 15 3 25 6 37 4 26 49 46 8 3 2 15 17 1 6 1 5 1 2 3 2 2 2 100 10 12 31 1 0 10 0 30 25 20 6 13 19 26 21 1 3 3 6 60
2 0 0 1 1 2 0 0 0 0 4 0 0 0 2 0 0 0 0 9 3 0 0 0 1 0 0 21 0 0 0 0 0 0 0 24 0 53 4 21 0 27 0 0 52 5 1 0 0 8 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,760.93 943.60 1,050.58 1,740.97 1,457.80 1,340.72 988.49 1,143.65 1,709.87 1,164.51 2,144.14 1,106.57 1,624.82 1,739.86 2,145.14 1,711.92 875.46 765.45 1,332.72 1,488.82 1,181.63 1,324.73 1,015.57 1,127.68 2,263.13 1,147.64 1,539.74 1,480.75 791.38 1,304.63 1,199.68 993.53 1,270.56 1,253.62 1,197.66 2,263.12 858.46 1,669.83 1,659.90 1,787.99 1,017.57 1,838.01 1,081.57 989.53 1,268.66 1,235.62 1,407.72 834.40 1,125.56 1,745.81 1,665.79
Table S1 page 20/159
NQVAMNPTNTVFDAKR NSLESYAFNMK NTTIPTK QATKDAGTIAGLNVLR QTQTFTTYSDNQPGVLIQVYEGER
RFDDAVVQSDMK RNTTIPTK SFYPEEVSSMVLTK SINPDEAVAYGAAVQAAILSGDK
Heterogeneous nuclear ribonucleoprotein U-like protein 1
HNRL1_HUMAN HNRNPUL1
95,722
100.00%
5
5
16
Chromobox protein homolog 3
CBX3_HUMAN CBX3
20,794
100.00%
6
7
19
Elongation factor 1-gamma
EF1G_HUMAN EEF1G
50,101
100.00%
12
13
79
Purine nucleoside phosphorylase
PNPH_HUMAN PNP
32,100
100.00%
14
17
116
SQIHDIVLVGGSTR STAGDTHLGGEDFDNR TTPSYVAFTDTER TVTNAVVTVPAYFNDSQR VCNPIITK VEIIANDQGNR VQVEYK VQVEYKGETK YKAEDEK 8.88% EALGGQALYPHVLVK HLPSTEPDPHVVR NYILDQTNVYGSAQR QGAPTSFLPPEASQLKPDR WDVLIQQATQCLNR 45.40% GFTDADNTWEPEENLDCPELIEAFLNSQK IIGATDSSGELMFLMK KVEEAEPEEFVVEK SLSDSESDDSK VEEAEPEEFVVEK WKDSDEADLVLAK 25.60% AKDPFAHLPK ALIAAQYSGAQVR EYFSWEGAFQHVGK FAETQPK ILGLLDAYLK KLDPGSEETQTLVR LDPGSEETQTLVR MAQFDAK QAFPNTNR STFVLDEFKR TFLVGER WFLTCINQPQFR 51.20% ANHEEVLAAGK DHINLPGFSGQNPLR DHINLPGFSGQNPLRGPNDER FEVGDIMLIR FGDRFPAMSDAYDR FPAMSDAYDR LEQFVSILMASIPLPDK LEQFVSILMASIPLPDKAS LGADAVGMSTVPEVIVAR LTQAQIFDYGEIPNFPR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
83.9 89.2 36.0 58.2 75.4 68.8 39.2 102.0 134.0 87.1 75.2 106.0 89.9 38.8 80.0 37.3 54.7 36.8 63.0 43.4 94.8 34.7 86.9 46.2 97.2 84.4 63.7 58.1 58.2 42.1 92.8 48.2 33.4 63.5 76.4 66.9 31.1 32.1 51.7 35.5 46.2 63.4 64.7 22.6 58.2 46.7 55.8 53.6 32.2 79.8 69.4
22.6 20.6 24.6 19.0 21.2 21.3 22.1 22.3 21.7 21.0 17.4 21.6 21.8 24.7 22.6 22.1 22.5 22.0 18.1 22.1 21.6 21.1 22.7 17.9 22.3 23.0 17.0 22.7 23.1 21.0 21.2 21.2 23.8 13.0 22.2 22.3 18.9 22.6 21.3 22.7 22.2 23.4 22.8 20.9 22.1 19.2 16.5 19.2 20.2 21.1 21.7
4 50 1 0 13 20 2 83 38 38 27 97 52 5 56 2 24 2 2 0 2 0 1 0 6 3 2 3 2 0 11 2 4 19 6 4 1 1 9 1 3 8 6 0 17 0 4 2 1 19 5
1 0 0 2 43 6 0 1 4 16 26 0 9 0 0 0 1 0 0 8 0 3 0 1 0 2 0 0 0 11 0 0 0 0 7 0 0 0 0 0 0 7 9 0 0 5 0 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,821.89 1,303.60 774.44 1,627.91 2,774.33 1,426.66 930.54 1,632.78 2,260.15 1,481.81 1,691.73 1,487.70 1,982.00 944.52 1,228.63 765.41 1,180.62 882.42 1,594.90 1,483.77 1,741.85 2,039.06 1,744.88 3,382.51 1,744.85 1,661.83 1,169.48 1,533.73 1,489.75 1,123.63 1,347.74 1,684.78 820.42 1,118.68 1,572.82 1,444.73 826.38 947.47 1,241.65 821.45 1,609.80 1,138.59 1,664.85 2,333.14 1,192.64 1,647.72 1,172.50 1,917.04 2,075.11 1,800.95 2,009.01
Table S1 page 21/159
Vimentin
VIME_HUMAN VIM
53,635
100.00%
3
3
63
3.43%
Asparaginyl-tRNA synthetase, cytoplasmic
SYNC_HUMAN NARS
62,926
100.00%
10
11
21
23.40%
UTP--glucose-1-phosphate uridylyltransferase
UGPA_HUMAN UGP2
56,924
100.00%
3
4
9
7.48%
Cullin-4B
CUL4B_HUMAN CUL4B
103,969
100.00%
4
4
5
4.93%
tRNA-nucleotidyltransferase 1, mitochondrial Ras-related protein Rab-5C
TRNT1_HUMAN TRNT1
50,112
100.00%
2
2
3
5.76%
RAB5C_HUMAN RAB5C
23,465
100.00%
3
3
6
17.10%
Ras-related C3 botulinum toxin substrate 1 6-phosphofructokinase type C
RAC1_HUMAN RAC1
21,433
100.00%
2
2
5
12.50%
K6PP_HUMAN PFKP
85,579
100.00%
3
3
4
6.51%
Annexin A2
ANXA2_HUMAN ANXA2
38,588
100.00%
28
37
986
69.90%
LVFGFLNGR STVPGHAGR VFGFSLITNK VIMDYESLEK FLEQQNK KLLEGEESR LLEGEESR EDGTFYEFGEDIPEAPER EGIDPTPYYWYTDQR EPFPTIYVDSQKENER FLTWILNR IFDSEEILAGYK KEDGTFYEFGEDIPEAPER LTESVDVLMPNVGEIVGGSMR MNYSDAIVWLK NLMFLVLR SPAGSIVHELNPNFQPPK GLPDNISSVLNK IQRPPEDSIQPYEK SFENSLGINVPR ETVEEQASTTER LPENYTDETWQK QYQIDAAIVR TIDGILLLIER EIGALLQQLR LQSPEFQSLFTEGLK GVDLQENNPASR LVLLGESAVGK QASPNIVIALAGNK LTPITYPQGLAMAK YLECSALTQR AIGVLTSGGDAQGMNAAVR EIGWTDVGGWTGQGGSILGTK NVIFQPVAELK AEDGSVIDYELIDQDAR AYTNFDAER AYTNFDAERDALNIETAIK DALNIETAIK DIISDTSGDFR DIISDTSGDFRK DLYDAGVKR ELASALK GLGTDEDSLIEIICSR GVDEVTIVNILTNR LMVALAK LSLEGDHSTPPSAYGSVK LYDSMK QDIAFAYQR RAEDGSVIDYELIDQDAR SALSGHLETVILGLLK SEVDMLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
62.5 39.3 75.8 47.7 47.6 56.2 43.0 68.1 52.6 29.8 41.5 38.0 34.7 77.0 57.1 40.9 70.8 31.7 57.5 67.0 31.7 48.6 49.8 40.1 51.3 58.4 73.8 43.1 43.5 55.1 46.2 80.9 100.0 34.8 101.0 66.7 72.7 74.5 75.3 57.6 47.6 37.7 98.8 105.0 44.8 77.1 34.8 82.0 99.0 89.0 35.4
21.0 22.1 20.0 22.2 24.2 23.9 23.5 18.3 20.2 22.0 19.8 22.7 19.7 22.3 22.4 18.9 22.7 22.2 22.0 23.1 20.7 21.4 23.0 14.9 18.1 21.2 21.7 20.1 18.2 20.8 21.9 22.8 22.0 20.3 21.0 19.4 22.1 24.5 20.8 22.4 23.2 23.5 22.4 21.3 24.2 22.5 18.9 22.3 22.3 11.1 22.8
4 1 19 7 58 1 4 2 2 0 2 1 0 2 4 2 2 1 2 4 1 1 2 1 2 1 2 2 2 4 1 1 2 1 31 14 38 23 6 6 4 1 74 116 12 15 1 79 22 36 4
0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 34 0 0 0 0 0 0 30 0 3 0 0 82 36 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,022.58 881.46 1,125.63 1,242.59 906.47 1,060.56 932.47 2,100.90 1,903.85 1,951.94 1,062.61 1,384.70 2,229.00 2,235.10 1,339.67 1,021.59 1,932.00 1,256.69 1,699.87 1,332.69 1,379.63 1,523.70 1,176.64 1,255.76 1,140.67 1,723.89 1,299.63 1,085.66 1,395.80 1,519.82 1,240.60 1,803.90 2,119.05 1,257.72 1,908.88 1,086.49 2,155.07 1,087.60 1,225.57 1,353.67 1,036.54 731.43 1,777.86 1,542.85 745.46 1,844.90 756.36 1,111.55 2,064.98 1,650.98 837.40
Table S1 page 22/159
Profilin-2
PROF2_HUMAN PFN2
15,028
99.50%
2
2
3
Aldo-keto reductase family 1 member C1
AK1C1_HUMAN AKR1C1
36,771
100.00%
4
5
27
SLYYYIQQDTK SLYYYIQQDTKGDYQK SVPHLQK SYSPYDMLESIR SYSPYDMLESIRK TDLEKDIISDTSGDFR TKGVDEVTIVNILTNR TNQELQEINR TPAQYDASELK VYKEMYK WISIMTER 19.30% EGFFTNGLTLGAK SQGGEPTYNVAVGR 45.50% AIDGLNR EEPWVDPNSPVLLEDPVLCALAK
HIDSAHLYNNEEQVGLAIR IADGSVKR LAIEAGFR LNDGHFMPVLGFGTYAPAEVPK
Actin-related protein 2/3 complex subunit 5 Aldo-keto reductase family 1 member B10
Desmocollin-3
ARPC5_HUMAN ARPC5
16,303
99.50%
2
2
3
AK1BA_HUMAN AKR1B10
36,003
100.00%
16
17
117
DSC3_HUMAN DSC3
99,953
100.00%
11
11
29
QLEMILNKPGLK QNVQVFEFQLTSEEMK REDIFYTSK RQLEMILNKPGLK RTPALIALR SIGVSNFNR TPALIALR YQLQR 16.60% ALAAGGVGSIVR QGNMTAALQAALK 55.70% ACNVLQSSHLEDYPFDAEY AKMPIVGLGTWK ALGVSNFSHFQIEK ATFLDAWEAMEELVDEGLVK DDKGNAIGGK HIDCAYVYQNEHEVGEAIQEK IKEIAAK IVENIQVFDFK LLNKPGLK LSDEEMATILSFNR MPIVGLGTWK NVIVIPK REDLFIVSK SGDDLFPK TAAQVLIR VAIDAGYR 10.50% AVALSDK AVALSDKK EVTVLLEHQK GVDKEPLNLFYIER NAGFQEYTIPITVK SFTIWLSDK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
74.2 71.4 30.7 76.7 64.6 87.7 92.7 69.0 75.0 38.2 37.0 35.5 58.2 37.0 29.4 82.9 45.2 46.2 59.8 56.0 91.6 38.6 28.1 37.6 53.8 70.5 30.5 83.8 56.9 53.9 29.8 83.6 101.0 35.9 38.9 40.3 99.3 32.4 92.3 59.7 41.1 50.8 60.7 61.2 33.0 40.4 35.3 53.3 31.6 74.8 52.5
23.0 21.7 19.2 21.1 23.0 22.2 18.1 23.6 23.1 22.8 22.2 22.6 22.2 22.6 21.3 22.0 23.3 23.1 21.7 17.6 21.3 21.6 14.5 10.0 22.6 14.8 22.5 19.8 23.0 17.4 19.2 23.0 21.5 22.0 20.3 19.8 21.2 11.5 22.4 21.4 13.6 21.1 22.3 21.0 23.8 25.8 21.9 19.2 21.7 21.6 21.6
86 3 1 28 21 16 6 71 39 4 5 1 2 2 0 0 1 52 3 9 5 15 0 2 6 31 2 2 1 2 0 10 2 2 0 2 24 2 23 11 2 11 10 11 1 1 2 4 0 2 5
0 2 0 0 0 25 10 0 0 0 0 0 0 0 1 56 0 0 16 0 0 0 2 0 0 0 0 0 0 0 1 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,421.70 2,012.96 808.47 1,460.67 1,588.77 1,811.87 1,771.99 1,244.62 1,222.60 976.48 1,051.52 1,354.70 1,434.70 758.42 2,591.31 2,179.09 845.48 876.49 2,360.18 1,383.80 1,972.93 1,158.58 1,539.90 1,010.65 993.51 854.55 707.38 1,070.63 1,316.70 2,257.97 1,300.75 1,576.81 2,282.09 974.49 2,532.15 772.49 1,351.73 882.58 1,625.78 1,101.61 782.51 1,106.62 878.43 871.54 864.46 703.40 831.49 1,195.67 1,692.90 1,580.83 1,096.57
Table S1 page 23/159
60S ribosomal protein L12
RL12_HUMAN RPL12
Deleted in malignant brain tumors 1 DMBT1_HUMAN DMBT1 protein
17,801
100.00%
5
5
13
38.20%
260,708
100.00%
4
4
31
1.78%
37,989
100.00%
9
9
248
28.80%
Follistatin
FST_HUMAN
Inositol monophosphatase 1
IMPA1_HUMAN IMPA1
30,171
100.00%
2
2
4
8.66%
Actin-related protein 2/3 complex subunit 1B
ARC1B_HUMAN ARPC1B
40,932
100.00%
3
4
19
11.30%
Adapter molecule crk
CRK_HUMAN CRK
33,813
100.00%
5
5
11
25.30%
Proline synthase co-transcribed bacterial homolog protein
PROSC_HUMAN PROSC
30,326
100.00%
7
7
20
32.40%
Nucleolin
NUCL_HUMAN NCL
76,598
100.00%
28
33
416
35.20%
FST
SSDPDFR VILNVPSK VILNVPSKLEADK VLNDGSVYTAR VNLEECFR CTGGEVGATSALAPK HSGNITFDEIVNIAR IGPLGLSPK KVGDDIAK QAQIEVVPSASALIIK FGQGSGPIVLDDVR LVNGDGR LVNGGDR QLGCGWATSAPGNAR CKEQPELEVQYQGR CVCAPDCSNITWK EQPELEVQYQGR GPVCGLDGK GRCSLCDELCPDSK LSTSWTEEDVNDNTLFK SIGLAYEGK TELSKEECCSTGR TYRNECALLK SLLVTELGSSR SSPVDLVTATDQK ASSEGGTAAGAGLDSLHK EVEERPAPTPWGSK TWKPTLVILR ALFDFNGNDEEDLPFK DSSTSPGDYVLSVSENSR IGDQEFDSLPALLEFYK IHYLDTTTLIEPVSR QEAVALLQGQR APLEVAQEH HGLPPSETIAIVEHINAK IGSTIFGER LMAVPNLFMLETVDSVK TFGENYVQELLEK TKPADMVIEAYGHGQR VQQAVAR ALELTGLK ALVATPGKK EALNSCNKR EAMEDGEIDGNK EAMEDGEIDGNKVTLDWAKPK EVFEDAAEIR FGYVDFESAEDLEK GFGFVDFNSEEDAK GIAYIEFK GLSEDTTEETLK GLSEDTTEETLKESFDGSVR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
49.2 36.7 54.3 91.4 38.2 94.4 40.3 50.5 40.0 49.5 93.7 37.0 37.0 43.9 38.9 61.2 81.1 33.6 34.7 110.0 57.8 32.3 33.0 64.5 74.2 95.1 49.1 48.2 83.1 74.0 91.9 37.3 73.4 33.3 34.5 63.7 63.8 79.1 62.7 45.2 58.9 32.0 38.2 72.2 48.7 70.9 97.9 81.0 45.0 71.5 94.7
20.1 14.0 16.6 23.6 22.2 22.6 22.1 11.5 23.4 12.8 22.5 21.9 21.9 21.1 24.6 17.2 22.2 21.6 16.6 21.6 21.3 16.9 22.6 21.9 24.0 21.9 22.4 14.8 20.8 19.2 22.5 21.0 20.4 23.3 20.0 22.0 21.8 23.3 22.0 18.9 20.7 16.3 21.8 14.1 21.3 23.5 19.2 17.4 20.2 22.7 21.3
2 2 2 4 4 2 1 4 2 4 26 1 1 3 0 5 10 1 12 174 41 1 0 2 2 6 1 0 2 2 2 0 4 1 0 2 5 7 0 2 20 1 1 13 0 8 13 59 18 13 5
0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 3 0 0 2 0 10 0 0 0 1 0 0 2 0 0 0 1 0 0 0 0 0 4 0 0 0 0 0 22
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
823.36 869.55 1,425.83 1,194.61 1,066.50 1,418.70 1,685.86 881.55 845.47 1,666.97 1,459.75 730.38 730.38 1,545.72 1,763.84 1,610.68 1,475.71 902.44 1,525.65 1,998.93 937.50 1,556.67 1,267.65 1,161.65 1,360.70 1,628.79 1,582.79 1,226.76 1,870.85 1,899.86 1,984.99 1,757.94 1,212.67 993.50 1,926.05 979.52 1,938.99 1,569.78 1,788.87 771.45 844.51 884.56 1,091.53 1,323.54 2,362.12 1,178.57 1,648.74 1,561.68 940.51 1,322.63 2,200.03
Table S1 page 24/159
IVTDRETGSSK KFGYVDFESAEDLEK KGAAIPAK NDLAVVDVR NSTWSGESK QGTEIDGR QKVEGTEPTTAFNLFVGNLNFNK
Triosephosphate isomerase
TPIS_HUMAN TPI1
26,651
100.00%
19
30
637
SISLYYTGEK TEADAEKTFEEK TGISDVFAK TLVLSNLSYSATEETLQEVFEK VAVATPAK VAVATPAKK VEGTEPTTAFNLFVGNLNFNK VTLDWAKPK VTQDELK VTQDELKEVFEDAAEIR 89.60% DCGATWVVLGHSER EAGITEK ELASQPDVDGFLVGGASLKPEFVDIINAK
RNA-binding protein FUS
FUS_HUMAN FUS
53,408
100.00%
5
6
11
FFVGGNWK HVFGESDELIGQK IAVAAQNCYK IIYGGSVTGATCK KFFVGGNWK KQSLGELIGTLNAAK QSLGELIGTLNAAK RHVFGESDELIGQK SNVSDAVAQSTR TATPQQAQEVHEK VAHALAEGLGVIACIGEK VIADNVKDWSK VPADTEVVCAPPTAYIDFAR VTNGAFTGEISPGMIK VVFEQTK VVLAYEPVWAIGTGK 12.70% AAIDWFDGK AAIDWFDGKEFSGNPIK APKPDGPGGGPGGSHMGGNYGDDR
Heterogeneous nuclear ribonucleoproteins C1/C2
HNRPC_HUMAN HNRNPC
33,653
100.00%
9
10
94
Protocadherin-1
PCDH1_HUMAN PCDH1
114,726
100.00%
10
11
114
GEATVSFDDPPSAK TGQPMINLYTDR 30.40% AAVAGEDGR GFAFVQYVNER LKGDDLQAIK MIAGQVLDINLAAEPK NDKSEEEQSSSSVK QKVDSLLENLEK VDSLLENLEK VFIGNLNTLVVK VPPPPPIAR 11.60% DMNDNAPTIEIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
49.8 77.6 40.9 70.8 53.8 58.5 49.0 52.0 65.8 55.6 129.0 47.7 33.5 109.0 48.6 40.7 94.3 88.2 32.2 67.6 32.3 89.2 58.8 115.0 38.0 99.7 102.0 64.9 98.2 77.8 119.0 57.7 78.0 99.0 45.1 112.0 62.3 37.3 28.0 76.7 41.0 53.5 85.8 37.5 99.1 72.4 54.0 48.2 85.2 32.4 76.7
22.9 22.1 18.1 21.6 20.4 22.0 20.8 23.7 21.4 20.9 21.1 15.4 16.3 21.6 21.4 24.5 21.9 21.5 24.5 18.4 20.7 22.9 23.2 22.5 21.3 16.5 21.0 22.5 22.7 22.7 20.2 23.4 21.8 22.4 21.9 19.4 22.3 22.6 16.8 21.7 22.7 20.6 22.3 21.3 19.7 19.8 21.3 24.0 13.6 18.1 20.3
1 2 1 24 12 19 0 19 9 34 17 3 1 42 3 12 7 15 1 0 4 38 18 16 3 21 28 3 42 64 30 11 6 14 5 124 2 1 0 3 2 2 12 1 16 6 4 4 46 2 16
0 0 0 0 0 0 2 0 4 0 3 0 0 12 0 0 12 12 0 51 0 37 0 0 2 22 1 8 0 5 45 0 2 5 0 4 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,192.62 1,776.83 755.48 1,000.54 995.44 875.42 2,568.31 1,160.58 1,397.64 937.50 2,501.27 756.46 884.56 2,312.16 1,057.60 832.44 1,991.99 1,586.74 747.39 3,029.58 954.48 1,458.72 1,137.57 1,326.67 1,082.58 1,542.89 1,414.79 1,614.82 1,234.60 1,466.72 1,807.97 1,274.67 2,192.07 1,621.83 850.47 1,602.89 1,022.49 1,894.93 2,268.97 1,420.66 1,424.68 845.41 1,329.66 1,100.63 1,682.92 1,553.69 1,415.77 1,159.62 1,316.79 943.57 1,404.64
Table S1 page 25/159
Poliovirus receptor
PVR_HUMAN PVR
45,284
100.00%
2
3
32
6.00%
S-adenosylmethionine synthase isoform type-2
METK2_HUMAN MAT2A
43,643
100.00%
6
7
25
16.70%
Filaggrin-2
FILA2_HUMAN FLG2
248,034
100.00%
3
3
24
1.71%
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase Aldehyde dehydrogenase family 1 member A3
DHX15_HUMAN DHX15
90,917
99.90%
2
2
6
3.14%
AL1A3_HUMAN ALDH1A3
56,091
100.00%
15
19
60
35.20%
EQQSTYTFQLK GLFTISPETGEIQVK LEVGAPYLR NTGLITVQGPVDREDLSTLR TGDIFTTETSIDR VQDGGSPPR VTVLDTNDNAPK WDSYDLTIK YFLQTTTPLDYEK VLAKPQNTAEVQK VQLTGEPVPMAR AAVDYQK DSFPWEVPK FVIGGPQGDAGLTGR HIGYDDSSK TQVTVQYMQDR YLDEDTIYHLQPSGR FSNSSSSNEFSK HQEEESETEEDEEDTPGHK QDGECGTLSK EVDDLGPEVGDIK TLATDILMGVLK ANSTDYGLTAAVFTK AVEAAQVAFQR EAGFPPGVVNIVPGFGPTVGAAISSHPQINK
Alpha-actinin-4
ACTN4_HUMAN ACTN4
104,839
100.00%
61
80
2114
EEIFGPVQPILK ELGEYALAEYTEVK GLFIKPTVFSEVTDNMR IAFTGSTEVGK IAKEEIFGPVQPILK IFINNEWHESK ILELIESGK ILELIESGKK KRPVGDPFDVK LLHQLADLVER TEQGPQIDQK VFVEEQVYSEFVR 70.70% AGTQIENIDEDFR AGTQIENIDEDFRDGLK AIMTYVSSFYHAFSGAQK ALDFIASK ASFNHFDKDHGGALGPEEFK ASIHEAWTDGK CQLEINFNTLQTK DDPVTNLNNAFEVAEK DGLAFNALIHR DHALLEEQSK DHGGALGPEEFK DLLLDPAWEK DYETATLSDIK EAILAIHK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
42.1 59.7 32.1 59.3 81.5 52.3 89.0 32.3 60.6 60.2 59.6 35.8 30.5 88.8 43.1 60.7 61.5 71.1 62.0 32.2 49.4 60.7 112.0 56.3 36.7 54.8 71.8 43.8 52.9 65.7 60.8 36.5 51.0 33.9 47.0 52.2 79.6 72.7 87.9 87.6 64.7 45.0 48.0 92.7 86.6 60.7 59.8 44.6 50.4 70.9 55.5
21.6 22.0 21.8 19.6 22.3 21.1 22.9 23.2 22.8 18.8 21.2 22.5 22.3 22.7 19.8 22.1 22.1 16.1 10.0 18.2 22.4 19.0 23.1 23.9 18.8 18.8 22.3 21.4 21.1 14.0 21.9 19.3 18.2 22.0 17.9 21.5 22.3 20.7 22.0 22.3 21.2 20.3 20.6 22.9 22.0 21.6 23.2 21.1 22.0 21.7 15.2
5 13 6 2 2 13 20 1 19 16 13 3 1 6 6 2 4 22 0 1 1 5 3 2 0 2 4 1 4 2 2 2 2 0 2 5 14 5 11 31 17 0 20 4 14 26 8 2 7 22 14
0 0 0 17 0 0 0 0 0 3 0 0 0 0 0 0 3 0 1 0 0 0 0 0 4 0 0 3 0 2 0 0 2 2 2 0 0 0 16 13 0 17 0 0 0 4 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,372.68 1,618.87 1,017.57 2,184.16 1,455.70 912.45 1,286.66 1,140.56 1,618.80 1,425.81 1,297.69 794.40 1,104.54 1,444.76 1,021.46 1,384.65 1,806.87 1,320.57 2,254.89 1,094.48 1,385.68 1,290.73 1,558.78 1,189.63 3,057.62 1,369.77 1,614.79 1,970.01 1,109.58 1,681.99 1,416.69 1,001.59 1,129.68 1,257.70 1,306.75 1,143.56 1,630.81 1,507.70 1,920.93 2,023.96 864.48 2,203.02 1,214.58 1,608.81 1,775.85 1,226.66 1,169.58 1,256.59 1,199.63 1,255.61 894.54
Table S1 page 26/159
EGLLLWCQR ELPPDQAEYCIAR ETTDTDTADQVIASFK FAIQDISVEETSAK GISQEQMQEFR GYEEWLLNEIR HEAFESDLAAHQDR HRDYETATLSDIK HRPELIEYDK HRPELIEYDKLR HTNYTMEHIR IAESNHIK ICDQWDALGSLTHSR ISIEMNGTLEDQLSHLK KDDPVTNLNNAFEVAEK KHEAFESDLAAHQDR LASDLLEWIR LDHLAEK LMLLLEVISGER LSGSNPYTTVTPQIINSK LSNRPAFMPSEGK LVSIGAEEIVDGNAK MAPYQGPDAVPGALDYK MEEIGR MLDAEDIVNTARPDEK MTLGMIWTIILR MVSDINNGWQHLEQAEK NFITAEELR NVNVQNFHISWK QFASQANVVGPWIQTK QGEAEFNR QLEAIDQLHLEYAK QQSNEHLR RQFASQANVVGPWIQTK STLPDADR STLPDADRER TFTAWCNSHLR TINEVENQILTR TIPWLEDR TIPWLEDRVPQK TIQEMQQK VEQIAAIAQELNELDYYDSHNVNTR
Splicing factor, arginine/serine-rich 2 SFRS2_HUMAN SFRS2
3-hydroxyisobutyrate
3HIDH_HUMAN HIBADH
25,459
100.00%
3
3
33
35,312
100.00%
7
8
18
VGWEQLLTTIAR VLAGDKNFITAEELR VLAVNQENEHLMEDYEK VQQLVPK YLDIPK 14.50% DAEDAMDAMDGAVLDGR VDNLTYR VGDVYIPR 31.80% DFSSVFQFLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
48.2 73.8 114.0 104.0 72.7 101.0 51.6 71.0 41.8 39.2 41.5 56.8 97.7 42.6 109.0 48.4 101.0 45.8 43.2 104.0 57.7 114.0 102.0 30.8 94.6 97.4 83.7 47.7 59.0 111.0 67.1 86.0 30.4 50.7 34.4 42.1 33.2 86.4 30.7 39.9 39.8 107.0 92.8 117.0 88.6 53.3 35.7 122.0 31.0 65.1 36.7
23.4 21.1 21.2 22.3 21.0 23.5 20.1 22.8 22.3 20.4 20.6 20.1 20.7 22.4 21.8 21.5 22.0 19.3 19.6 21.3 23.1 22.0 22.2 23.0 22.0 20.2 21.1 23.3 22.2 21.9 21.5 21.7 20.8 20.6 21.7 22.3 22.0 22.5 22.7 20.7 22.5 20.7 20.5 20.5 21.8 15.4 19.0 13.8 23.1 22.8 22.7
26 14 78 225 48 73 0 6 0 0 0 13 8 0 29 0 38 13 1 57 19 180 53 3 20 49 8 7 8 39 5 52 1 0 1 7 1 61 1 9 4 0 180 12 8 12 14 15 1 17 1
0 0 3 0 0 0 4 34 44 2 15 0 27 9 66 6 0 0 0 4 31 0 0 0 38 0 6 0 0 2 0 4 0 4 0 17 0 0 0 0 0 44 0 21 17 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,174.60 1,561.73 1,741.81 1,537.78 1,368.62 1,421.71 1,625.73 1,548.77 1,299.67 1,568.86 1,301.61 911.50 1,758.82 1,943.98 1,903.94 1,753.83 1,215.67 825.45 1,388.78 1,920.01 1,433.72 1,514.81 1,808.85 734.35 1,832.87 1,479.81 2,014.93 1,092.57 1,485.76 1,773.93 950.43 1,670.88 1,011.50 1,930.03 874.43 1,159.57 1,392.65 1,429.77 1,029.54 1,481.81 1,021.50 2,905.40 1,386.77 1,675.90 2,060.96 811.50 748.42 1,783.71 880.45 918.51 1,245.63
Table S1 page 27/159
dehydrogenase, mitochondrial
Bone morphogenetic protein 1
BMP1_HUMAN BMP1
111,231
100.00%
13
13
73
UPF0568 protein C14orf166
CN166_HUMAN C14orf166
28,051
100.00%
3
3
6
22,022
99.50%
2
2
4
138,335
100.00%
2
2
4
Peptidyl-prolyl cis-trans isomerase F, PPIF_HUMAN PPIF mitochondrial TPP2_HUMAN TPP2 Tripeptidyl-peptidase 2
DLGLAQDSATSTK EFQDAGEQVVSSPADVAEK GSLLIDSSTIDPAVSK MGAVFMDAPVSGGVGAAR SPILLGSLAHQIYR TPVGFIGLGNMGNPMAK 15.70% AAAFLGDIALDEEDLR AGFAVNFFK DYGHIQSPNYPDDYRPSK ENIQPGQEYNFLK FVSDGSINK FYSDNSVQR GDIAQAR GGGPQAISIGK GIFLDTIVPK KPEPVLATGSR LPEPIVSTDSR YCGSGPPEEVYSAGDSVLVK YCGYEKPDDIK 15.60% AGVMALANLLQIQR LTQDAVAK NAEPLINLDVNNPDFK 18.40% FPDENFTLK GSGDPSSSSSSGNPLVYLDVDANGKPLGR
Heterogeneous nuclear ribonucleoprotein D-like
HNRDL_HUMAN HNRPDL
46,421
99.50%
2
2
2
Polypeptide Nacetylgalactosaminyltransferase 2
GALT2_HUMAN GALNT2
64,715
100.00%
12
12
31
Inositol-3-phosphate synthase 1
INO1_HUMAN ISYNA1
61,050
100.00%
4
4
11
Translin
TSN_HUMAN TSN
26,165
99.50%
2
4
6
SUMO-conjugating enzyme UBC9
UBC9_HUMAN UBE2I
17,990
100.00%
3
4
10
1.84% GTLTEAFPVLGGK VPITAVIAAK 10.00% DLTEYLSR FGEVVDCTIK GFGFVLFK VFVGGLSPDTSEEQIK 25.20% AAEVWMDEYK EIILVDDYSNDPEDGALLGK FNQVESDKLR FYFEELGK GGFDWNLVFK NFYYAAVPSAR QHPYTFPGGSGTVFAR QKWEQIEGNSK TPMIAGGLFVMDK VRGADAAQAK WDYMTPEQR WPDFNQEAYVGGTMVR 8.78% APLVPPGSPVVNALFR VFVGGDDFK VGPVAATYPMLNK VIVLWTANTER 15.40% EAVTEILGIEPDREK EILTLLQGVHQGAGFQDIPK 20.30% KDHPFGFVAVPTK MLFKDDYPSSPPK VEYEKR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
67.3 90.3 48.3 87.7 51.0 63.3 88.4 63.7 20.4 72.3 31.3 49.6 45.5 59.6 46.8 39.2 60.0 111.0 42.3 58.5 30.4 74.2 42.8 73.8 56.4 37.5 31.1 55.7 40.5 35.2 44.1 127.0 29.8 30.2 43.6 53.8 55.8 41.3 63.1 32.0 48.5 61.7 32.4 31.2 48.7 72.8 59.4 75.8 47.1 81.1 31.4
22.7 20.0 21.0 21.4 18.5 22.2 22.3 21.6 20.2 22.8 22.5 20.0 21.9 18.9 18.2 19.9 22.3 21.0 19.1 19.5 23.4 21.9 22.5 20.7 21.1 7.8 21.8 22.7 22.9 22.6 19.1 22.1 23.5 22.3 21.7 21.9 22.6 22.9 21.9 21.3 16.9 20.6 15.8 21.6 22.4 21.4 21.5 17.9 21.4 22.7 22.0
2 2 2 5 2 3 3 18 0 12 2 2 6 2 10 2 12 2 1 3 1 2 2 0 2 2 1 13 13 1 2 7 0 1 2 2 0 2 5 1 2 3 2 1 4 4 1 1 2 2 2
0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 2 0 0 0 2 0 0 0 0 0 0 0 0 0 2 2 4 0 0
0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,306.65 2,005.94 1,602.86 1,724.81 1,567.90 1,735.85 1,718.86 1,000.53 2,151.97 1,579.78 966.49 1,115.51 730.38 984.55 1,102.65 1,154.65 1,213.64 2,113.98 1,387.62 1,513.85 845.47 1,812.91 1,110.55 2,833.36 1,289.71 982.63 996.50 1,167.57 914.51 1,705.87 1,257.55 2,176.07 1,235.64 1,032.50 1,182.59 1,258.62 1,721.84 1,346.67 1,411.70 986.54 1,241.53 1,885.85 1,633.94 983.48 1,360.73 1,301.72 1,698.89 2,164.18 1,442.78 1,540.74 823.43
Table S1 page 28/159
Cleavage and polyadenylation specificity factor subunit 6 Complement factor D
CPSF6_HUMAN CPSF6
59,193
99.50%
2
2
2
CFAD_HUMAN CFD
27,014
100.00%
3
4
23
Lysyl oxidase homolog 4
LOXL4_HUMAN LOXL4
84,463
100.00%
10
13
53
42,806
99.50%
2
2
3
Nucleosome assembly protein 1-like NP1L4_HUMAN NAP1L4 4 Hexokinase-1
HXK1_HUMAN HK1
102,470
100.00%
12
13
28
Thioredoxin reductase 1, cytoplasmic
TRXR1_HUMAN TXNRD1
70,889
100.00%
9
11
19
7.08% AVSDASAGDYGSAIETLVTAISLIK TPLSEAEFEEIMNR 22.10% AVPHPDSQPDTIDHDLLLLQLSEK RPDSLQHVLLPVLDR VQVLLGAHSLSQPEPSK 17.10% AQEVVMSGVR FSTQIYNLGR GSWAEEPR GYLSETVSNALGPQGR LGQGLGPIHLSEVR LVGPESKPEEGR QHSPVTEGAVEVK SADHMDWPYGYR VVCGMLGFPSEVPVDSHYYR YGQGEGPIWLDNVR 10.10% AAATAEEPDPK FYEEVHDLER LDNVPHTPSSYIETLPK 16.00% ASGVEGADVVK ATDCVGHDVVTLLR GAALITAVGVR GAAMVTAVAYR GDFIALDLGGSSFR GKFNTSDVSAIEK HIDLVEGDEGR ITPELLTR LRTEASS LVDEYSLNAGK SANLVAATLGAILNR TPDGTENGDFLALDLGGTNFR 17.60% FLIATGERPR KLMHQAALLGQALQDSR LMHQAALLGQALQDSR MIEAVQNHIGSLNWGYR QFVPIKVEQIEAGTPGR VEQIEAGTPGR VMVLDFVTPTPLGTR VVGFHVLGPNAGEVTQGFAAALK
UPF0027 protein C22orf28
CV028_HUMAN C22orf28
55,192
99.50%
2
2
4
Plakophilin-1
PKP1_HUMAN PKP1
82,845
100.00%
3
3
5
Insulin-like growth factor-binding protein 5
IBP5_HUMAN IGFBP5
30,552
100.00%
5
7
61
Complement factor B
CFAB_HUMAN CFB
85,515
100.00%
6
6
11
VVYENAYGQFIGPHR 4.95% QIGNVAALPGIVHR SYNDELQFLEK 5.09% LLQSGNSDVVR SPNQNVQQAAAGALR VMGNQVFPEVTR 22.80% EHEEPTTSEMAEETYSPK FVGGAENTAHPR HMEASLQELK IISAPEMR QDEEKPLHALLHGR 9.42% EAGIPEFYDYDVALIK EKLQDEDLGFL
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
51.5 51.9 41.9 44.9 32.0 65.3 67.2 42.4 88.6 48.7 41.1 49.5 34.2 46.4 70.6 45.1 48.4 28.3 35.8 67.0 38.3 54.4 35.0 63.2 53.3 35.0 37.3 74.7 77.9 109.0 34.8 34.0 39.7 44.5 62.3 58.0 99.9 69.9 61.4 31.4 35.8 48.2 104.0 32.2 92.6 76.8 44.7 37.7 42.8 61.4 44.5
19.6 22.6 20.6 16.6 19.0 23.7 21.0 17.6 23.3 19.5 22.0 22.2 15.9 21.0 22.0 21.8 21.0 21.0 23.3 22.1 18.6 22.5 22.3 22.0 21.9 18.2 22.5 23.2 17.9 21.5 22.0 20.5 21.3 22.2 18.4 22.1 21.0 18.1 22.5 17.2 20.5 22.2 22.1 22.7 15.2 22.1 21.4 23.6 20.9 22.4 23.3
1 1 0 0 0 7 8 4 7 2 1 2 0 0 7 2 4 0 2 1 1 1 2 2 3 1 1 2 4 1 2 0 0 0 2 2 4 0 1 0 2 2 2 1 4 18 11 6 0 2 2
0 0 3 16 2 0 0 0 0 8 2 2 1 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 7 0 0 1 2 1 1 0 0 2 1 2 0 0 0 0 6 0 0 0 7 0 0
0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,452.28 1,665.78 2,681.38 1,758.00 1,789.98 1,091.55 1,198.62 931.43 1,648.83 1,475.83 1,297.68 1,380.71 1,497.62 2,328.08 1,603.79 1,099.53 1,336.62 1,910.99 1,031.54 1,555.79 1,027.63 1,125.57 1,454.73 1,395.71 1,239.60 942.56 763.40 1,208.62 1,483.86 2,210.04 1,159.66 1,896.01 1,767.92 2,003.98 1,869.02 1,156.60 1,661.89 2,282.23 1,749.87 1,444.84 1,385.66 1,187.64 1,524.79 1,376.70 2,094.88 1,255.62 1,201.59 932.49 1,642.87 1,842.92 1,306.65
Table S1 page 29/159
F-actin-capping protein subunit alpha-1
CAZA1_HUMAN CAPZA1
32,905
100.00%
13
16
83
QLNEINYEDHK VASYGVKPR VSEADSSNADWVTK YGLVTYATYPK 67.50% DVQDSLTVSNEAQTAK EASDPQPEEADGGLK EGAAHAFAQYNMDQFTPVK ESCDSALR FITHAPPGEFNEVFNDVR FTITPPTAQVVGVLK IEGYEDQVLITEHGDLGNSR IIENAENEYQTAISENYQTMSDTTFK
IQVHYYEDGNVQLVSHK KEASDPQPEEADGGLK LLLNNDNLLR TIDGQQTIIACIESHQFQPK VSDEEKVR HLA class I histocompatibility antigen, Cw-12 alpha chain
1C12_HUMAN HLA-C
40,867
99.50%
2
2
12
Cystatin-C
CYTC_HUMAN CST3
15,781
100.00%
9
12
108
Insulin-like growth factor-binding protein 6
IBP6_HUMAN IGFBP6
25,304
100.00%
4
6
732
13,509
100.00%
3
3
5
Small nuclear ribonucleoprotein Sm SMD2_HUMAN SNRPD2 D2 Mesothelin
MSLN_HUMAN MSLN
68,970
100.00%
13
15
123
Drebrin-like protein
DBNL_HUMAN DBNL
48,188
100.00%
4
4
12
16.40% DGEDQTQDTELVETRPAGDGTFQK FDSDAASPR SWTAADTAAQITQR WAAVVVPSGEEQR 62.30% AFCSFQIYAVPWQGTMTLSK ALDFAVGEYNK ASNDMYHSR KQIVAGVNYFLDVELGR LVGGPMDASVEEEGVR LVGGPMDASVEEEGVRR QIVAGVNYFLDVELGR RALDFAVGEYNK TQPNLDNCPFHDQPHLK 16.20% APAVAEENPK GAQTLYVPNCDHR HLDSVLQQLQTEVYR RHLDSVLQQLQTEVYR 24.60% EEEEFNTGPLSVLTQSVK NNTQVLINCR REEEEFNTGPLSVLTQSVK 20.80% ANVDLLPR EIDESLIFYK FVAESAEVLLPR GLLPVLGQPIIR GSLLSEADVR IQSFLGGAPTEDLK LLGPHVEGLK LLGPHVEGLKAEER LLPAALACWGVR LRTDAVLPLTVAEVQK QLDVLYPK TDAVLPLTVAEVQK VNAIPFTYEQLDVLK 13.50% FQDVGPQAPVGSVYQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
33.7 43.4 94.2 67.7 98.7 90.3 30.5 43.4 51.1 65.7 61.2 61.3 40.7 73.6 72.5 66.1 59.3 67.8 63.5 81.4 55.7 57.9 70.7 73.0 102.0 106.0 37.8 115.0 38.5 71.2 73.9 43.4 129.0 53.7 89.0 62.3 34.5 31.3 56.9 55.6 50.5 53.9 84.0 43.8 48.4 40.0 96.4 47.3 101.0 67.5 102.0
21.9 20.8 20.6 22.8 23.4 19.5 20.6 18.3 21.7 14.8 22.1 18.5 22.2 22.0 19.2 22.1 24.0 20.8 22.1 23.7 23.0 21.2 22.9 18.1 18.1 21.2 21.3 20.7 22.9 21.7 20.9 20.8 21.8 20.2 22.1 23.4 22.2 17.6 22.4 21.6 9.0 23.7 23.3 17.0 19.6 20.5 14.0 21.1 19.5 20.0 22.1
1 2 2 2 6 14 0 1 2 10 0 0 0 2 14 1 2 0 6 6 14 6 38 8 6 12 5 19 2 2 393 6 238 0 2 2 0 2 9 4 6 8 30 2 0 3 10 6 10 16 4
0 0 0 0 0 0 3 0 4 0 5 3 11 1 0 0 0 12 0 0 0 0 0 0 3 0 4 3 0 0 0 3 91 1 0 0 1 0 0 0 0 0 0 4 2 0 11 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,402.66 976.56 1,508.69 1,275.66 1,705.82 1,542.69 2,140.98 937.41 2,089.01 1,570.92 2,245.07 3,056.37 2,029.01 1,670.79 1,197.70 2,314.15 961.50 2,637.19 965.43 1,519.75 1,427.73 2,351.12 1,226.61 1,080.45 1,921.05 1,660.79 1,800.89 1,792.96 1,382.71 2,060.96 1,025.53 1,530.71 1,828.96 1,985.06 2,006.99 1,231.62 2,163.09 897.52 1,256.64 1,330.74 1,275.82 1,046.55 1,475.77 1,062.63 1,547.85 1,326.74 1,753.02 975.55 1,483.84 1,749.94 1,719.87
Table S1 page 30/159
Protein S100-A16
S10AG_HUMAN S100A16
11,784
100.00%
4
4
6
Small nuclear ribonucleoproteinassociated proteins B and B' Thrombospondin-1
RSMB_HUMAN SNRPB
24,593
100.00%
2
2
11
TSP1_HUMAN THBS1
129,364
100.00%
25
28
433
VAGTGEGGLEEMVEELNSGK VKDPNSGLPK YQEQGGEASPQR 36.90% AADKLIQNLDANHDGR AVIVLVENFYK LIHEQEQQSSS LIQNLDANHDGR 9.58% GENLVSMTVEGPPPK VLGLVLLR 25.00% AQGYSGLSVK CEGSSVQTR DHSGQVFSVVSNGK DLASIAR FQMIPLDPK FTGSQPFGQGVEHATANK FVFGTTPEDILR FYVVMWK GFLLLASLR GGVNDNFQGVLQNVR GPDPSSPAFR GTLLALER GTSQNDPNWVVR IEDANLIPPVPDDKFQDLVDAVR
Nucleoprotein TPR
TPR_HUMAN TPR
TRI29_HUMAN TRIM29 Tripartite motif-containing protein 29 AN32B_HUMAN ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B
267,271
100.00%
11
11
20
65,818
100.00%
2
2
3
28,771
100.00%
3
4
40
IMADSGPIYDK IPESGGDNSVFDIFELTGAAR KIMADSGPIYDK LCNNPTPQFGGK LVPNPDQK MENAELDVPIQSVFTR NALWHTGNTPGQVR QVTQSYWDTNPTR SITLFVQEDR TIVTTLQDSIR VTEENKELANELR 5.80% ASTALSNEQQAR EGVQGPLNVSLSEEGK ELENANDLLSATK LDELQASDVSVK LQEQVTDLR NIEELQQQNQR NLQEQTVQLQSELSR QTEEQVNDLKER SQEQILEILR TETMNVVMETNK TLSSVQNEVQEALQR 3.06% EQDAVDQVK VIMDALDER 28.70% DISTLEPLK IFGGLDMLAEK KLELSENR LKDISTLEPLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
87.5 45.1 65.5 60.6 65.6 39.6 28.5 70.4 52.1 37.2 55.8 61.7 41.6 44.9 83.3 69.2 43.3 61.6 93.9 50.2 59.8 52.2 56.0 55.2 133.0 51.8 62.0 38.2 117.0 55.9 97.2 53.9 66.4 53.7 53.3 41.7 53.1 63.4 59.3 61.4 96.3 33.7 54.5 64.6 86.7 39.4 33.0 33.0 62.3 46.1 50.2
21.4 20.0 23.3 22.7 17.4 20.9 22.6 23.2 6.0 20.2 20.3 22.7 25.5 24.0 22.3 22.6 23.3 13.8 23.5 20.3 21.8 21.2 20.0 23.2 22.2 22.7 22.6 19.6 22.6 22.3 22.1 23.3 21.2 23.1 22.6 22.4 22.6 24.4 23.1 21.3 21.8 22.2 24.8 20.0 22.2 21.9 23.6 21.5 22.4 23.4 17.5
2 0 4 0 2 1 0 6 5 2 1 1 4 11 17 79 1 8 56 7 8 22 0 12 7 2 15 3 51 5 21 2 64 2 4 1 1 2 2 2 1 1 3 1 2 1 2 3 21 6 6
0 2 0 2 0 0 1 0 0 0 0 0 0 0 4 0 0 0 1 0 0 0 26 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,021.93 1,054.59 1,349.61 1,750.88 1,294.74 1,285.60 1,365.69 1,554.78 882.61 1,009.53 1,023.45 1,460.71 745.42 1,088.58 1,875.90 1,394.73 988.50 989.61 1,616.81 1,030.50 872.52 1,372.66 2,579.34 1,209.58 2,195.06 1,353.67 1,332.64 910.50 1,864.91 1,550.78 1,595.75 1,207.63 1,246.70 1,544.79 1,275.63 1,642.83 1,417.72 1,303.67 1,101.59 1,399.69 1,772.91 1,488.73 1,228.69 1,428.64 1,701.88 1,031.50 1,077.53 1,015.57 1,209.62 988.54 1,256.75
Table S1 page 31/159
UBA3_HUMAN UBA3 NEDD8-activating enzyme E1 catalytic subunit Puromycin-sensitive aminopeptidase PSA_HUMAN NPEPPS
51,835
99.50%
2
2
2
103,261
100.00%
22
25
86
Nuclear autoantigenic sperm protein NASP_HUMAN NASP
85,218
100.00%
4
5
16
LLPQLTYLDGYDR LPNLTHLNLSGNK SLDLFNCEVTNLNDYR 5.83% IQDFNDTFYR LQEVLDYLTNSASLQMK 28.10% AFFESHPAPSAER AGIISTVEVLK ATLEEAR DAESIHQYLLQR DLSLPPVDR DNWEELYNR DYFNVPYPLPK ETALLIDPK IDFVGELNDK KPYPDDENLVEVK LGLQNDLFSLAR LGWDPKPGEGHLDALLR LNLGTVGFYR LSVEGFAVDK SPVYLTVLK TIQQCCENILLNAAWLK TQYSSAMLESLLPGIR VALSNMNVIDR VLGATLLPDLIQK VTLSFPSTLQTGTGTLK YAAVTQFEATDAR YQGGFLISR 7.49% EAEGSSAEYKK EAQLYAAQAHLK EIEELKELLPEIR HLVMGDIPAAVNAFQEAASLLGK
Small proline-rich protein 2E
SPR2E_HUMAN SPRR2E
7,837
100.00%
4
4
88
Transitional endoplasmic reticulum ATPase
TERA_HUMAN VCP
89,307
100.00%
28
34
195
66.70% CPEPCPPPK CPPVTPSPPCQPK CPQPCPPQQCQQK QPCQPPPVCPTPK 42.80% AFEEAEK AIANECQANFISIK DVDLEFLAK ELQELVQYPVEHPDK ETVVEVPQVTWEDIGGLEDVKR
EVDIGIPDATGR GGNIGDGGGAADR GILLYGPPGTGK GPELLTMWFGESEANVR GVLFYGPPGCGK IVSQLLTLMDGLK KAFEEAEK KGDIFLVR KYEMFAQTLQQSR LAGESESNLR LAGESESNLRK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
69.2 76.2 103.0 49.3 86.5 39.4 62.0 47.2 64.8 30.0 49.9 47.8 34.1 56.2 43.0 86.9 34.1 61.2 56.3 48.9 68.2 69.0 74.2 91.2 76.0 99.6 54.2 39.0 47.8 66.4 38.8 52.2 32.6 54.9 47.2 35.8 63.5 63.3 73.4 81.2 71.2 75.1 58.7 55.2 35.2 112.0 32.0 45.2 95.2 73.9 54.4
21.9 19.9 20.7 20.5 22.0 21.1 18.2 24.9 21.6 21.6 19.8 22.7 20.5 23.8 23.1 21.6 21.1 21.6 23.5 14.0 22.3 22.5 23.8 11.8 17.9 21.2 21.0 21.5 21.8 18.8 20.8 20.0 22.0 18.1 23.1 20.0 22.6 23.0 22.3 20.5 21.9 20.1 21.2 21.6 22.8 17.9 23.0 17.6 22.1 22.7 23.6
4 6 5 1 1 2 5 2 2 1 2 6 2 2 2 7 0 3 2 3 2 2 4 18 2 3 4 1 2 5 0 69 1 2 16 2 2 6 4 2 9 5 9 2 1 20 1 11 3 4 6
0 7 0 0 0 0 0 0 2 0 0 0 0 0 0 0 6 0 0 0 0 1 0 0 0 0 0 0 0 1 7 0 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 2 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,566.82 1,420.79 1,972.91 1,318.61 1,969.00 1,445.68 1,129.68 789.41 1,472.75 1,011.55 1,238.54 1,352.69 999.57 1,149.58 1,545.78 1,346.74 1,873.99 1,139.62 1,064.56 1,019.61 2,075.04 1,781.91 1,231.65 1,380.85 1,750.96 1,442.69 1,040.55 1,198.56 1,342.71 1,610.90 2,368.23 1,081.48 1,464.70 1,655.71 1,505.72 823.38 1,578.80 1,049.55 1,823.92 2,498.28 1,242.63 1,116.50 1,172.67 1,951.92 1,251.62 1,446.82 951.48 947.57 1,629.81 1,075.54 1,203.63
Table S1 page 32/159
Peptidyl-prolyl cis-trans isomerase FKBP4
FKBP4_HUMAN FKBP4
51,788
100.00%
10
10
49
Eukaryotic initiation factor 4A-I
IF4A1_HUMAN EIF4A1
46,137
100.00%
15
18
65
LDQLIYIPLPDEK LGDVISIQPCPDVK LIVDEAINEDNSVVSLSQPK MDELQLFR NAPAIIFIDELDAIAPK NVFIIGATNRPDIIDPAILRPGR QAAPCVLFFDELDSIAK QTNPSAMEVEEDDPVPEIR RIVSQLLTLMDGLK SVSDNDIR VINQILTEMDGMSTK WALSQSNPSALR 29.00% AEASSGDHPTDTEMKEEQK ATESGAQSAPLPMEGVDISPK AWDIAIATMK EGTGTEMPMIGDR FEIGEGENLDLPYGLER LAEEENKAK LYANMFER QDEGVLK RGEAHLAVNDFELAR SNTAGSQSQVETEA 39.40% ATQALVLAPTR DFTVSAMHGDMDQK DQIYDIFQK EELTLEGIR ELAQQIQK ENYIHR GFKDQIYDIFQK GIYAYGFEKPSAIQQR GYDVIAQAQSGTGK KEELTLEGIR LNSNTQVVLLSATMPSDVLEVTK
SAP domain-containing ribonucleoprotein
SARNP_HUMAN SARNP
23,653
100.00%
6
6
12
Mucin-2
MUC2_HUMAN MUC2
540,252
100.00%
6
6
37
Eukaryotic translation initiation factor 3 subunit G
EIF3G_HUMAN EIF3G
35,594
100.00%
3
3
4
LQMEAPHIIVGTPGR MFVLDEADEMLSR QFYINVER VLITTDLLAR 34.30% FGISSVPTK FGIVTSSAGTGTTEDTEAK FGLNVSSISR FNVPVSLESK GLSSDNKPMVNLDK ITSEIPQTER 1.35% HETQEVLIK SNNDFTTR TASGLVEATGAGFANTWK TCGCVGPDNVPR TFDGDVFR TVHMMPMQVQVQVNR 7.19% ADDNATIR LPGELEPVQATQNK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
78.0 52.9 110.0 63.1 95.9 30.1 69.4 76.8 45.5 36.7 94.9 77.9 45.0 72.8 62.8 52.4 104.0 40.0 46.6 35.9 45.2 75.9 55.3 43.4 32.3 32.5 39.3 34.0 67.4 71.7 121.0 48.1 64.9 58.5 105.0 38.2 55.7 49.7 98.5 47.7 31.8 69.6 48.8 38.2 39.2 102.0 35.6 45.5 41.2 47.5 39.6
20.3 22.0 20.8 23.0 18.6 12.8 21.6 20.3 14.8 22.5 22.7 22.9 16.6 21.6 23.3 17.1 22.1 24.0 19.4 23.0 22.0 17.4 18.1 14.1 23.4 23.7 20.5 21.0 22.8 21.2 23.1 22.7 19.5 21.3 20.5 22.6 17.6 20.9 21.6 22.0 23.6 22.4 23.5 19.6 18.8 22.8 19.0 20.3 21.8 22.0 21.4
14 1 5 6 34 0 8 4 2 2 9 10 0 7 2 9 8 1 2 2 0 6 3 2 1 1 5 1 4 3 4 2 2 4 11 2 10 3 2 2 2 2 1 5 2 20 1 5 0 2 1
0 0 0 0 2 1 2 0 2 0 0 0 10 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 2 0 1 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,556.86 1,540.80 2,170.12 1,051.52 1,811.00 2,518.43 1,923.95 2,171.98 1,586.93 905.43 1,679.84 1,329.69 2,105.89 2,101.01 1,135.58 1,425.60 1,950.95 1,031.54 1,059.49 788.42 1,697.87 1,408.62 1,140.67 1,613.66 1,169.58 1,059.57 957.54 831.41 1,501.77 1,827.94 1,394.69 1,187.66 2,475.30 1,618.87 1,571.71 1,068.55 1,114.68 935.52 1,871.89 1,079.58 1,119.60 1,533.76 1,173.61 1,096.60 954.43 1,780.89 1,331.58 956.45 1,845.88 875.42 1,523.81
Table S1 page 33/159
Eukaryotic translation initiation factor 5A-1
IF5A1_HUMAN EIF5A
16,815
100.00%
8
11
27
RADDNATIR 55.20% EDLRLPEGDLGK IVEMSTSK KYEDICPSTHNMDVPNIK LPEGDLGKEIEQK NDFQLIGIQDGYLSLLQDSGEVR
TPP1_HUMAN TPP1
61,230
100.00%
6
6
13
6-phosphogluconate dehydrogenase, 6PGD_HUMAN PGD decarboxylating
53,124
100.00%
11
12
103
46,424
100.00%
14
15
46
Tripeptidyl-peptidase 1
NGFVVLK VHLVGIDIFTGK VHLVGIDIFTGKK 16.00% ILSGRPPLGFLNPR LFGGNFAHQASVAR LSELVQAVSDPSSPQYGK LYQQHGAGLFDVTR VNTELMK YLTLENVADLVRPSPLTLHTVQK
Serpin H1
SERPH_HUMAN SERPINH1
26.90% AGQAVDDFIEK FQDTDGK GILFVGSGVSGGEEGAR HEMLPASLIQAQR IISYAQGFMLLR LVPLLDTGDIIIDGGNSEYR NPELQNLLLDDFFK SAVENCQDSWR TVSKVDDFLANEAK VDDFLANEAK YGPSLMPGGNK 42.30% AATLAER AVAISLPK AVLSAEQLR AVLSAEQLRDEEVHAGLGELLR DQAVENILVSPVVVASSLGLVSLGGK
Chloride intracellular channel protein CLIC4_HUMAN CLIC4 4
Phosphoglycerate mutase 1
PGAM1_HUMAN PGAM1
28,756
100.00%
9
11
32
28,787
100.00%
17
24
165
DTQSGSLLFIGR GVVEVTHDLQK HLAGLGLTEAIDK HLAGLGLTEAIDKNK LSSLIILMPHHVEPLER LYGPSSVSFADDFVR SAGLAFSLYQAMAK SALQSINEWAAQTTDGK TGLYNYYDDEKEK 47.80% AGSDGESIGNCPFSQR FLDGNEMTLADCNLLPK FSAYIK GVVFSVTTVDLK HPESNTAGMDIFAK LDEYLNSPLPDEIDENSMEDIK LFMILWLK NFDIPK NSRPEANEALER YLTNAYSR 69.70% ALPFWNEEIVPQIK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
33.8 43.7 42.8 33.5 55.9 74.3 51.4 57.5 46.7 30.4 87.2 95.5 54.9 44.4 41.5 61.5 31.1 107.0 53.7 59.8 116.0 80.4 48.0 78.2 77.1 75.6 31.9 37.1 37.3 53.0 73.1 79.8 51.0 46.5 57.2 18.5 71.9 58.1 90.5 51.4 94.2 70.9 34.2 56.0 34.4 51.9 40.8 37.2 39.8 40.1 74.7
22.4 22.5 21.5 21.5 21.4 21.0 19.9 19.2 15.6 13.8 23.1 22.0 22.3 23.8 14.8 23.1 19.3 23.0 22.3 22.3 21.5 22.4 16.1 22.7 23.6 22.3 25.1 15.8 22.0 19.2 14.3 22.9 21.1 19.2 18.5 17.2 21.8 22.4 23.3 20.9 18.6 21.8 19.5 19.0 20.4 20.4 16.6 24.5 21.9 20.5 20.6
1 2 1 0 2 4 2 4 0 0 1 6 0 2 0 7 1 54 4 3 13 2 2 2 8 6 1 1 2 0 1 9 4 2 0 0 7 2 2 2 2 4 4 2 2 5 4 1 5 2 34
0 2 0 2 0 2 0 4 2 1 0 0 2 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 4 6 0 0 0 2 0 0 0 0 0 0 0 0 0 0 2 0 0 3 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,031.52 1,341.70 910.46 2,161.01 1,455.77 2,580.30 776.47 1,298.75 1,426.84 1,536.90 1,474.76 1,904.96 1,604.82 850.43 2,607.45 1,192.59 810.36 1,591.81 1,509.78 1,427.77 2,160.12 1,705.88 1,351.57 1,536.79 1,121.55 1,136.54 731.41 798.51 986.56 2,405.28 2,551.43 1,293.68 1,224.66 1,337.74 1,579.88 1,984.11 1,659.80 1,457.75 1,819.88 1,637.73 1,681.72 1,950.93 728.40 1,264.72 1,533.70 2,579.17 1,079.63 733.39 1,385.68 987.49 1,683.91
Table S1 page 34/159
AMEAVAAQGK FSGWYDADLSPAGHEEAK FSGWYDADLSPAGHEEAKR HGEAQVK HGESAWNLENR HLEGLSEEAIMELNLPTGIPIVYELDK
Serine/threonine-protein phosphatase PPP6_HUMAN PPP6C 6 catalytic subunit
35,127
100.00%
3
4
7
11.10%
HYGGLTGLNK KAMEAVAAQGK NLKPIKPMQFLGDEETVR NLKPIKPMQFLGDEETVRK RGGQALR RSYDVPPPPMEPDHPFYSNISK SYDVPPPPMEPDHPFYSNISK VLIAAHGNSLR YADLTEDQLPSCESLK YADLTEDQLPSCESLKDTIAR APLDLDKYVEIAR GAGWLFGAK VTNEFVHINNLK IQEGVFDINNEANGIK TASNVEEAFINTAK YIIIGDTGVGK AMLESIGVPLEK APWELLELR IDVGEAEPR NSEPEEVIPSR QVEPLDPPAGSAPGEHVFVK VDAQFGGIDQR VSYYENVIK ELAEEKR KLNQALLDLHALGSAR LGGPEAGLGEYLFER HIGLVYSGMGPDYR LAQQYYLVYQEPIPTAQLVQR LVQIEYALAAVAGGAPSVGIK YNEDLELEDAIHTAILTLK
Ras-related protein Rab-2A
RAB2A_HUMAN RAB2A
23,528
100.00%
3
3
8
19.30%
Tyrosyl-tRNA synthetase, cytoplasmic
SYYC_HUMAN YARS
59,127
100.00%
7
7
14
15.30%
Ferritin light chain
FRIL_HUMAN FTL
20,003
100.00%
3
3
5
21.70%
Proteasome subunit alpha type-2
PSA2_HUMAN PSMA2
25,881
100.00%
4
8
47
32.10%
Glutathione synthetase
GSHB_HUMAN GSS
52,368
100.00%
18
18
99
42.80% AIEHADGGVAAGVAVLDNPYPV AIENELLAR ALAEGVLLR ASYILMEK CPDIATQLAGTK EGGGNNLYGEEMVQALK EGIAQTVFLGLNR GLALGIAK GSLDQDR ILSNNPSK QDDFTAR QIEINTISASFGGLASR QQLEELAR QYSLQNWEAR SADGSPALK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
68.3 82.3 41.9 47.5 79.2 34.3 49.6 73.1 54.3 30.3 30.1 43.2 43.7 58.0 87.8 47.0 68.6 47.8 70.8 102.0 101.0 43.7 35.8 41.9 53.7 39.4 30.7 79.3 37.1 36.2 35.3 59.2 73.1 89.0 44.2 119.0 65.2 53.8 73.2 61.6 71.6 72.5 80.6 40.3 33.9 33.0 36.4 124.0 43.1 60.7 44.2
23.2 19.8 20.5 19.5 21.2 19.8 23.0 23.5 20.5 18.5 20.9 20.6 19.9 18.2 20.5 21.0 21.8 21.7 21.5 23.0 23.4 21.7 22.6 20.7 20.8 21.8 22.0 23.7 22.8 24.4 14.8 23.2 22.3 18.8 14.0 20.9 21.9 21.4 16.5 20.2 22.8 21.9 21.1 18.2 19.9 22.3 21.0 21.6 21.4 22.5 22.0
3 8 0 2 12 0 10 5 4 0 1 0 4 12 2 0 1 2 2 2 4 2 2 2 2 2 0 2 2 1 0 2 6 4 1 2 15 4 16 8 3 8 9 2 2 2 4 6 3 6 4
0 19 6 0 1 1 0 1 5 0 0 3 0 9 0 4 2 0 0 0 0 0 0 0 0 0 2 0 0 0 2 0 5 1 18 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 6 10 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
991.49 1,979.88 2,135.98 768.40 1,312.60 3,039.56 1,059.56 1,103.59 2,115.13 2,243.22 757.44 2,589.21 2,433.11 1,150.67 1,868.86 2,425.16 1,502.82 906.48 1,427.76 1,760.88 1,494.74 1,135.64 1,286.70 1,126.63 985.50 1,256.61 2,074.06 1,205.59 1,114.58 874.46 1,719.99 1,607.81 1,580.75 2,521.35 2,027.15 2,201.13 2,135.08 1,028.57 941.58 954.50 1,274.64 1,808.85 1,417.78 742.48 790.37 872.48 852.39 1,763.93 986.53 1,294.62 845.44
Table S1 page 35/159
SDYMFQR TFEDISEK VQQELSRPGMLEMLLPGQPEAVAR
N-acetyl-D-glucosamine kinase
NAGK_HUMAN NAGK
37,359
99.90%
2
2
3
Mucin-4
MUC4_HUMAN MUC4
231,563
100.00%
3
3
4
Exostosin-1
EXT1_HUMAN EXT1
86,239
100.00%
5
6
23
Catenin alpha-1
CTNA1_HUMAN CTNNA1
100,055
100.00%
4
5
17
Coatomer subunit epsilon
COPE_HUMAN COPE
34,465
100.00%
5
5
11
Glutamine synthetase
GLNA_HUMAN GLUL
42,047
100.00%
4
4
6
Cleavage and polyadenylation specificity factor subunit 5
CPSF5_HUMAN NUDT21
26,210
100.00%
5
6
14
Eukaryotic translation initiation factor 3 subunit C
EIF3C_HUMAN EIF3C
105,329
100.00%
3
3
6
Ig kappa chain C region
IGKC_HUMAN IGKC
11,591
99.50%
2
2
15
Integrin alpha-2
ITA2_HUMAN ITGA2
129,280
100.00%
4
4
6
Dipeptidyl peptidase 9
DPP9_HUMAN DPP9
98,246
100.00%
5
5
7
Heterogeneous nuclear ribonucleoprotein Q
HNRPQ_HUMAN SYNCRIP
69,586
100.00%
10
10
52
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
95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
30.9 43.2 26.2 45.2 46.9 65.0 41.5 77.3 26.9 92.8 30.0 45.7 44.7 98.2 63.0 84.4 73.4 88.3 31.1 52.8 33.0 86.2 30.7 42.8 38.5 54.3 66.4 41.0 76.8 74.2 52.2 48.0 48.4 57.1 68.6 140.0 55.4 36.6 31.7 84.3 31.0 39.0 33.7 38.7 54.1 39.9 75.9 51.8 37.7 44.6 50.8
13.0 21.1 20.8 17.8 12.3 16.9 22.1 20.5 20.8 22.6 17.1 9.5 22.0 15.8 22.5 22.3 22.8 22.3 23.7 18.2 16.0 22.6 19.3 21.8 19.8 22.5 18.8 21.4 22.3 22.3 19.4 16.7 22.5 22.6 20.3 20.1 22.6 21.7 21.8 22.4 22.4 20.9 23.1 22.2 16.0 21.3 23.0 21.1 22.0 23.1 23.2
1 5 0 1 0 1 2 1 0 7 1 4 4 6 4 4 2 2 1 0 0 4 1 2 2 1 2 2 2 4 2 2 2 2 11 4 2 2 1 1 0 2 1 2 1 2 23 6 5 3 5
0 0 1 0 2 0 0 0 1 6 0 0 0 1 0 0 0 0 0 3 1 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
962.40 968.46 2,681.38 1,036.62 1,875.07 1,025.61 1,574.78 1,975.92 2,369.21 1,734.90 1,413.83 1,153.73 1,082.55 1,970.12 1,449.70 1,818.88 1,445.73 2,097.01 721.40 2,155.18 2,283.27 1,734.81 702.35 1,295.63 956.53 1,824.90 1,117.66 932.52 1,752.87 1,745.91 1,489.84 1,111.68 1,134.62 1,130.58 1,946.03 2,135.97 1,174.65 1,140.59 1,911.99 2,292.12 1,676.88 1,391.76 1,193.58 1,335.64 2,104.88 927.51 1,593.81 1,142.54 845.44 1,708.85 1,292.63
Table S1 page 36/159
TGYTLDVTTGQR TKEQILEEFSK VTEGLTDVILYHQPDDK VWGNVGTVEWADPIEDPDPEVMAK
5'-nucleotidase domain-containing protein 1
NT5D1_HUMAN NT5DC1
51,830
100.00%
5
6
10
Nardilysin
NRDC_HUMAN NRD1
131,558
100.00%
5
5
11
Aldose reductase
ALDR_HUMAN AKR1B1
35,836
100.00%
7
7
66
16.00% DIVAAIQHNYK MMTPEVLAEAYGK SQRPEESEPLEK TAGYYPNPPLVLSSDETLISK VVYFGDSMHSDIFPAR 4.09% ANLVLLSGANEGK GSLSNAGDPEIVK LGADESEEEGR LGADESEEEGRR TVFQFDVQR 26.30% EELFIVSK GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR
Osteopontin
OSTP_HUMAN SPP1
35,405
100.00%
9
10
52
MPILGLGTWK NLVVIPK REELFIVSK SPPGQVTEAVK TTAQVLIR VAIDVGYR 37.60% AIPVAQDLNAPSDWDSR ANDESNEHSDVIDSQELSK DSYETSQLDDQSAETHSHK GKDSYETSQLDDQSAETHSHK ISHELDSASSEVN KANDESNEHSDVIDSQELSK QLYNKYPDAVATWLNPDPSQK QNLLAPQNAVSSEETNDFKQETLPSK
SYIM_HUMAN IARS2 Isoleucyl-tRNA synthetase, mitochondrial TNF6B_HUMAN TNFRSF6B Tumor necrosis factor receptor superfamily member 6B Neuroblast differentiation-associated AHNK_HUMAN AHNAK protein AHNAK
113,776
100.00%
2
2
3
32,661
99.50%
2
2
18
629,086
100.00%
10
10
85
Ig alpha-1 chain C region
IGHA1_HUMAN IGHA1
37,636
99.50%
2
2
3
Aconitate hydratase, mitochondrial
ACON_HUMAN ACO2
85,410
100.00%
10
11
21
YPDAVATWLNPDPSQK 1.98% DSFLGSIPGK EMTADVIELK 10.30% LLQALEAPEGWGPTPR LTELLGAQDGALLVR 2.19% ADIDVSGPK GEGPDVDVNLPK GEGPEVDVNLPK VDIDVPDVNIEGPDAK VDIDVPDVNIEGPEGK VDIEGPDVNIEGPEGK VDVDIPDVNIEGPDAK VDVDVPDVNIEGPDAK VDVEVPDVSLEGPEGK 7.37% QEPSQGTTTFAVTSILR SAVQGPPER 17.20% DGYAQILR DINQEVYNFLATAGAK DSSGQHVDVSPTSQR EGWPLDIR IVYGHLDDPASQEIER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
43.9 58.2 42.5 43.8 39.7 50.1 46.0 74.0 32.6 104.0 59.2 66.3 50.0 35.7 41.2 33.9 53.7 37.2 45.2 75.6 64.5 47.0 98.1 26.9 43.4 52.4 56.6 43.5 35.5 58.7 81.2 35.1 34.0 54.1 91.7 47.5 55.0 43.2 56.3 50.9 57.3 43.6 72.0 49.0 46.9 37.3 47.6 79.6 43.7 33.2 35.1
22.5 22.3 22.5 21.0 21.7 21.0 22.3 20.8 21.2 21.9 22.9 17.9 19.4 22.2 19.9 18.7 20.5 13.6 20.6 20.5 18.5 22.9 22.7 18.5 16.8 18.1 20.5 20.2 21.1 21.3 22.4 22.5 23.1 21.4 17.7 22.1 22.6 22.3 22.6 22.4 22.4 22.4 22.6 21.6 22.0 21.9 23.3 22.0 21.1 20.8 21.9
2 2 0 1 2 2 2 2 0 4 2 2 0 1 2 0 28 4 16 23 12 7 18 0 0 0 6 0 0 0 6 2 1 7 11 28 15 8 8 4 1 2 13 6 1 2 2 2 2 1 0
0 0 3 0 0 0 1 0 1 0 0 0 2 0 0 2 0 0 0 0 0 0 0 1 4 3 0 3 2 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,311.65 1,351.71 1,942.98 2,670.24 1,271.67 1,471.68 1,428.70 2,265.17 1,856.86 1,285.71 1,286.66 1,191.51 1,347.61 1,139.59 964.54 3,262.68 1,115.63 782.51 1,120.64 1,112.60 901.55 892.49 1,854.90 2,116.93 2,177.92 2,363.04 1,387.63 2,245.02 2,448.22 2,888.43 1,801.88 1,020.54 1,164.58 1,734.92 1,568.90 901.46 1,239.62 1,253.64 1,695.84 1,695.84 1,667.81 1,695.84 1,681.83 1,668.83 1,835.95 940.49 935.50 1,753.88 1,599.74 985.51 1,841.90
Table S1 page 37/159
Cathepsin B
CATB_HUMAN CTSB
37,803
100.00%
10
13
86
26.30%
Protein-arginine deiminase type-3
PADI3_HUMAN PADI3
74,725
100.00%
9
9
19
17.50%
Lamin-B1
LMNB1_HUMAN LMNB1
66,392
100.00%
6
6
13
12.80%
Endoplasmic reticulum resident protein 29
ERP29_HUMAN ERP29
28,977
100.00%
6
6
17
27.60%
NSFL1 cofactor p47
NSF1C_HUMAN NSFL1C
40,555
100.00%
9
12
24
33.80%
LTGSLSGWSSPK NAVTQEFGPVPDTAR QGLLPLTFADPADYNK SQFTITPGSEQIR WVVIGDENYGEGSSR DIMAEIYK HYGYNSYSVSNSEK ICEPGYSPTYK LCGTFLGGPKPPQR LPASFDAR SGVYQHVTGEMMGGHAIR TDQYWEK TDQYWEKI VMFTEDLK VMFTEDLKLPASFDAR ALLFQGVVDDEQVK ATAFFPDLVNMLVLGK HVLGQDK ILGPDFGYVTR ILIGGNLPGSSGR SVSGLDSFGNLEVSPPVVANGK TISINQVLSNK TLPVVFDSPR TQGPAALFDDHK ALYETELADAR IESLSSQLSNLQK IGDTSVSYK IQELEDLLAK LLEGEEER LSSEMNTSTVNSAR NSQGEEVAQR DGDFENPVPYTGAVK ESYPVFYLFR FDTQYPYGEK GALPLDTVTFYK ILDQGEDFPASEMTR SLNILTAFQK ASSSILIDESEPTTNIQIR DLIHDQDEDEEEEEGQR EANLLNAVIVQR LGAAPEEESAYVAGEK LGAAPEEESAYVAGEKR LGSTAPQVLSTSSPAQQAENEAK
Spectrin alpha chain, brain
SPTA2_HUMAN SPTAN1
284,525
100.00%
59
66
256
SGFSLDNGELR SPNELVDDLFK SYQDPSNAQFLESIR 29.40% AALLELWELR ADVVESWIGEK ALINADELASDVAGAEALLDR DLAALEDKVK DLAALGDKVNSLGETAER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
54.7 67.6 69.0 41.4 54.3 33.1 80.1 52.7 53.6 51.1 65.4 38.1 62.5 35.0 45.5 63.1 61.7 36.7 38.2 75.1 34.4 39.2 44.0 36.4 53.2 38.3 30.9 36.4 39.2 67.2 66.6 72.1 43.5 31.5 56.7 92.5 68.3 78.2 105.0 51.8 63.2 67.1 74.0 51.0 62.1 108.0 53.1 43.1 114.0 45.5 43.6
23.1 22.6 22.3 23.2 21.4 21.6 19.1 20.5 21.8 24.5 21.5 19.4 21.5 22.0 22.6 22.5 20.4 20.1 21.7 20.2 21.6 21.6 23.2 21.7 22.8 21.7 20.4 22.9 21.6 22.1 20.4 22.1 23.7 18.9 20.6 21.1 18.1 22.1 14.3 18.9 22.7 22.0 22.1 23.0 23.4 21.5 20.0 23.8 21.4 21.4 22.1
2 2 3 2 2 3 5 6 3 7 1 3 26 2 1 2 4 2 1 3 1 2 2 0 4 1 1 2 2 2 3 2 2 1 5 3 4 1 1 2 2 1 2 2 4 5 5 4 4 3 0
0 0 0 0 0 0 0 0 2 0 15 0 0 0 12 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 1 0 0 0 0 0 2 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,219.63 1,601.79 1,762.90 1,463.75 1,667.77 998.49 1,634.71 1,314.60 1,527.81 876.46 1,961.90 969.43 1,082.52 982.49 1,855.93 1,560.83 1,751.94 796.43 1,237.66 1,240.70 2,173.11 1,216.69 1,130.62 1,299.63 1,251.62 1,446.78 969.49 1,171.66 974.48 1,512.70 1,117.52 1,608.75 1,320.66 1,247.56 1,324.72 1,724.78 1,134.65 2,074.07 2,085.85 1,339.77 1,620.78 1,776.88 2,314.15 1,194.58 1,276.64 1,754.84 1,213.69 1,232.62 2,127.09 1,101.62 1,858.95
Table S1 page 38/159
DLASVQALLR DLIGVQNLLK DLSSVQTLLTK DLTGVQNLR DLTNVQNLQK DLTSWVTEMK DTEQVDNWMSK DVDEIEAWISEK DVDETISWIK DVEDEETWIR DVTGAEALLER EAALTSEEVGADLEQVEVLQK EANELQQWINEK EANQQQQFNR EELYQNLTR EKEPIAASTNR ELPTAFDYVEFTR GKDLIGVQNLLK GLVSSDELAK GNAMVEEGHFAAEDVK GVIDMGNSLIER HQAFEAEVQANSGAIVK IAALQAFADQLIAAGHYAK IDGITIQAR ITALDEFATK KVEDLFLTFAK LAALADQWQFLVQK LDILDQER LFGAAEVQR LGESQTLQQFSR LIQEQHPEEELIK LIQNNHYAMEDVATR LIQSHPESAEDLQEK LLEATELK LLVGSEDYGR LNDSYR LQIASDENYKDPTNLQGK LQQLFR LQQSHPLSATQIQVK LQTASDESYKDPTNIQSK LSDDNTIGKEEIQQR LTVLSEER MNEVISLWK MTLVASEDYGDTLAAIQGLLK NQALNTDNYGHDLASVQALQR NTTGVTEEALK QEQIDNQTR REELITNWEQIR SADESGQALLAAGHYASDEVR SQLLGSAHEVQR SSLSSAQADFNQLAELDR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
72.8 50.5 72.3 59.4 50.9 37.1 44.0 39.0 52.7 72.2 72.3 80.6 69.7 45.0 31.4 26.6 56.6 40.5 32.6 64.2 49.7 29.1 35.3 45.6 45.8 45.0 60.3 35.7 68.3 64.5 54.8 43.5 72.2 31.0 49.3 36.1 77.5 30.8 50.9 76.0 76.9 47.8 43.2 82.8 47.8 31.1 44.2 37.9 61.9 66.2 133.0
21.2 18.6 21.0 22.4 22.3 23.2 17.8 22.4 23.9 20.2 23.5 21.2 21.6 21.6 23.1 23.7 22.6 14.9 24.0 20.1 22.8 22.0 19.8 22.0 22.4 18.8 20.7 21.2 24.1 22.9 21.6 22.4 22.2 20.9 22.3 21.8 22.5 21.2 18.2 21.8 22.7 22.9 23.3 21.3 22.4 23.8 20.7 22.2 21.6 22.2 21.7
8 3 7 3 4 6 1 1 1 9 9 1 4 8 2 0 5 4 2 2 4 0 0 2 6 4 4 1 13 4 5 0 7 1 4 3 1 2 0 3 1 4 5 2 0 1 2 0 0 5 7
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 4 0 1 2 0 0 0 0 0 0 0 0 4 2 0 0 0 3 0 4 3 6 0 0 0 2 0 0 2 8 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,085.63 1,112.67 1,204.68 1,015.55 1,172.63 1,209.58 1,352.58 1,433.68 1,205.61 1,291.58 1,173.61 2,258.14 1,501.73 1,262.59 1,165.59 1,215.63 1,587.77 1,297.78 1,018.54 1,719.76 1,319.66 1,798.91 1,972.07 986.56 1,108.59 1,310.74 1,630.90 1,001.53 990.54 1,393.71 1,605.85 1,790.85 1,723.85 916.54 1,108.56 767.37 2,034.01 804.47 1,677.93 2,024.98 1,745.87 946.52 1,119.59 2,225.14 2,328.13 1,162.60 1,131.54 1,586.83 2,147.00 1,324.70 1,951.94
Table S1 page 39/159
TATDEAYKDPSNLQGK VLETAEDIQER VNEVNQFAAK ADYSGMSSGSGLYAQK IKDLFPDGSISSSTK LGFDLFK NNDLSMFVLLPNDIDGLEK YYHASLEPVDFVNAADESR AALPEGLPEASR AANMHAQIK ASLEDLGWADWVLSPR TDTGVSLQTYDDLLAK SGNYPSSLSNETDR VDQETLTEMVKPSIDYVR AQFEGIVTDLIR DAGQISGLNVLR DSETGENIR KDSETGENIR LLGQFTLIGIPPAPR LYSPSQIGAFVLMK NAVITVPAYFNDSQR NTTIPTK QAVTNPNNTFYATK RYDDPEVQK SQVFSTAADGQTQVEIK STNGDTFLGGEDFDQALLR TTPSVVAFTADGER VINEPTAAALAYGLDK VLENAEGAR VQQTVQDLFGR NPPDVDGVIGEIR YDASILLWK IVQEFYDPMTPVNAR VFDSLLNLSSTLQATR ASKPLPPAPAPDEYLVSPITGEK IGEEEIQKPEEK VMQQQQQTTQQQLPQK VQAQVIQETIVPK AIKVEQATKPSFESGR GFAFVTFESPADAK IVEVLLMK LFIGGLNTETNEK VEQATKPSFESGR EALTYDGALLGDR EEVVQKEQE GSNMDFREPTEEER
Serpin B13
SPB13_HUMAN SERPINB13
44,259
100.00%
5
5
8
19.40%
Growth/differentiation factor 15
GDF15_HUMAN GDF15
34,137
100.00%
4
4
6
17.20%
LanC-like protein 2
LANC2_HUMAN LANCL2
50,838
99.50%
2
2
2
7.11%
Stress-70 protein, mitochondrial
GRP75_HUMAN HSPA9
73,663
100.00%
15
15
58
28.60%
Myelin protein zero-like protein 2
MPZL2_HUMAN MPZL2
24,466
99.50%
2
2
6
10.20%
Claudin-1
CLD1_HUMAN CLDN1
22,726
99.50%
2
2
5
14.70%
Splicing factor 3A subunit 1
SF3A1_HUMAN SF3A1
88,868
100.00%
4
4
10
8.07%
Heterogeneous nuclear ribonucleoprotein G
HNRPG_HUMAN RBMX
42,316
100.00%
5
7
19
13.00%
Eukaryotic translation initiation factor 4H
IF4H_HUMAN EIF4H
27,368
100.00%
4
5
15
23.80%
Splicing factor, arginine/serine-rich 1 SFRS1_HUMAN SFRS1
27,727
100.00%
10
11
90
44.40% DGTGVVEFVR DGYDYDGYR EAGDVCYADVYR GGPPFAFVEFEDPR
TVATPLNQVANPNSAIFGGARPR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
73.9 71.1 72.5 64.8 30.6 42.8 86.6 37.4 38.8 40.4 78.5 57.7 59.0 29.2 70.7 65.2 49.8 63.7 42.3 43.0 52.0 36.0 88.5 44.4 70.0 97.8 88.8 98.2 61.5 77.0 69.1 40.3 62.1 74.0 29.6 55.0 71.6 55.5 38.5 76.1 32.0 80.0 60.5 82.7 46.9 37.4 43.9 66.8 60.4 68.1 65.2
22.3 22.5 23.6 19.0 21.8 19.8 22.3 21.5 22.4 20.9 22.0 22.1 17.4 22.0 21.4 22.9 19.1 22.9 10.4 21.8 22.9 24.6 22.7 22.8 22.2 21.8 22.7 21.2 21.0 23.4 22.2 21.2 21.8 19.2 19.4 22.1 21.8 16.8 21.5 22.3 18.8 22.3 23.1 23.4 22.3 16.3 18.8 22.9 11.5 17.0 21.3
8 6 6 2 1 2 2 0 1 1 2 2 1 0 3 7 2 2 4 2 2 1 3 3 8 2 4 2 9 5 4 2 3 2 0 2 4 2 0 3 1 9 2 6 3 1 0 22 6 4 7
4 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 1 0 0 0 1 0 0 2 3 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,737.83 1,302.65 1,119.58 1,637.71 1,594.83 839.47 2,163.06 2,183.00 1,210.64 999.50 1,814.91 1,739.87 1,526.67 2,139.06 1,361.74 1,242.68 1,020.46 1,148.55 1,592.95 1,569.84 1,694.85 774.44 1,568.77 1,149.55 1,808.90 2,055.96 1,450.72 1,645.88 958.50 1,290.68 1,380.71 1,108.60 1,779.87 1,764.95 2,377.27 1,428.72 1,957.98 1,452.84 1,747.93 1,486.72 944.59 1,435.74 1,435.72 1,393.70 1,117.54 1,712.72 2,351.26 1,078.55 1,123.43 1,417.61 1,564.74
Table S1 page 40/159
GGPPFAFVEFEDPRDAEDAVYGR
HDHD2_HUMAN HDHD2 Haloacid dehalogenase-like hydrolase domain-containing protein PLAK_HUMAN JUP Junction plakoglobin
28,519
100.00%
2
2
4
13.10%
81,728
100.00%
10
10
55
17.00%
Cell adhesion molecule 4
CADM4_HUMAN CADM4
42,766
99.90%
2
2
9
6.44%
Alpha-galactosidase A
AGAL_HUMAN GLA
48,750
100.00%
5
5
19
13.50%
CD44 antigen
CD44_HUMAN CD44
81,535
100.00%
4
4
24
5.80%
40S ribosomal protein S25
RS25_HUMAN RPS25
13,725
99.50%
2
2
2
15.20%
Calpain-1 catalytic subunit
CAN1_HUMAN CAPN1
81,875
100.00%
9
10
50
12.30%
Serpin B8
SPB8_HUMAN SERPINB8
42,750
100.00%
5
5
12
18.40%
Cytochrome c
CYC_HUMAN CYCS
11,731
100.00%
6
7
20
49.50%
IYVGNLPPDIR KEDMTYAVR SHEGETAYIR TKDIEDVFYK VVVSGLPPSGSWQDLK DGLALGPGPFVTALEYATDTK LLLDGAPLIAIHK ALMGSPQLVAAVVR HPEAEMAQNSVR ISEDKNPDYR LAEPSQLLK LLNDEDPVVVTK LNYGIPAIVK LVQNCLWTLR NLALCPANHAPLQEAAVIPR SAIVHLINYQDDAELATR TMQNTSDLDTAR FQLEEFSPR LHQYDGSIVVIQNPAR ALLQDKDVIAINQDPLGK NFADIDDSWK QEIGGPR SILDWTSFNQER SYTIAVASLGK ALSIGFETCR ESSETPDQFMTADETR FAGVFHVEK TEAADLCK AALQELLSK LITPAVVSER APSDLYQIILK GQVVSLIR KAPSDLYQIILK LYELIITR NYLSIFR NYPATFWVNPQFK QLAGEDMEISVK RPTELLSNPQFIVDGATR YLGQDYEQLR ADFSGMSTEK GFQSLLSEVNR ISEVLDAGTVDPLTK LEESYDLEPFLR LGMIDAFDEAK LVLVNAIYFK ADLIAYLK GIIWGEDTLMEYLENPK GIIWGEDTLMEYLENPKK KTGQAPGYSYTAANK TGPNLHGLFGR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
37.0 54.8 43.4 42.9 62.2 39.5 70.3 45.4 73.5 42.3 27.4 35.7 72.9 52.9 60.4 46.1 27.0 56.2 55.8 35.9 43.7 38.2 38.7 72.2 34.2 58.0 83.6 42.3 41.4 39.3 35.6 63.3 43.3 72.3 45.5 31.5 70.7 59.1 52.0 58.2 52.9 57.5 105.0 48.0 58.0 32.0 62.3 93.6 98.9 98.8 70.8
20.5 21.6 21.1 22.0 22.2 21.0 21.8 7.0 20.1 20.4 22.0 17.5 21.3 18.1 23.1 19.4 21.8 19.9 22.2 20.4 17.5 19.7 20.7 22.1 19.6 22.6 10.4 22.9 20.9 20.0 18.6 18.9 21.0 16.7 14.6 20.5 22.6 22.4 21.2 21.4 14.0 23.3 22.2 22.9 23.2 14.0 17.4 22.5 22.0 22.6 21.7
0 17 8 6 8 5 2 2 17 2 0 1 7 16 6 0 0 2 7 0 0 2 2 7 4 6 1 8 9 1 1 12 3 12 5 1 6 2 1 2 1 3 2 2 4 4 4 4 2 2 3
3 0 0 0 4 0 0 0 0 0 1 0 0 0 0 2 1 0 0 2 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,541.17 1,256.70 1,128.54 1,162.55 1,257.64 1,668.90 2,136.09 1,373.85 1,427.80 1,384.63 1,236.59 998.59 1,341.73 1,087.65 1,302.70 2,155.14 2,029.04 1,352.61 1,152.57 1,809.96 1,951.09 1,210.54 756.40 1,495.72 1,109.62 1,153.57 1,859.76 1,033.55 907.42 972.57 1,084.64 1,260.72 871.54 1,388.82 1,020.61 912.49 1,611.80 1,335.65 2,014.07 1,284.62 1,088.46 1,249.65 1,557.84 1,510.74 1,209.58 1,179.71 906.53 2,023.97 2,136.07 1,556.77 1,168.62
Table S1 page 41/159
Superoxide dismutase [Cu-Zn]
SODC_HUMAN SOD1
15,917
100.00%
2
2
5
Amidophosphoribosyltransferase
PUR1_HUMAN PPAT
57,381
99.50%
2
2
4
26S proteasome non-ATPase regulatory subunit 9 Collagenase 3
PSMD9_HUMAN PSMD9
24,635
99.50%
2
3
5
MMP13_HUMAN MMP13
53,804
100.00%
7
7
14
TGQAPGYSYTAANK 16.90% GDGPVQGIINFEQK HVGDLGNVTADK 4.26% EVLPGEIVEISR IVLVDDSIVR 9.42% KLGQSESQGPPR SDVDLYQVR 22.70% DPGALMFPIYTYTGK ENAASSMTER IVNYTPDMTHSEVEK LDDNTLDVMK LIEEDFPGIGDKVDAVYEK SHFMLPDDDVQGIQSLYGPGDEDPNPK
UPF0424 protein C1orf128
CA128_HUMAN C1orf128
24,160
100.00%
3
3
7
GDP-fucose protein Ofucosyltransferase 1 Programmed cell death protein 5
OFUT1_HUMAN POFUT1
43,938
99.90%
2
2
3
PDCD5_HUMAN PDCD5
14,267
99.50%
2
2
2
Partner of Y14 and mago
WIBG_HUMAN WIBG
22,638
99.50%
2
2
6
Apoptosis-inducing factor 1, mitochondrial
AIFM1_HUMAN AIFM1
66,884
100.00%
4
4
10
Glia maturation factor beta
GMFB_HUMAN GMFB
16,696
99.50%
2
2
3
Lupus La protein
LA_HUMAN
46,821
100.00%
7
7
25
Platelet-activating factor acetylhydrolase IB subunit gamma Catalase
PA1B3_HUMAN PAFAH1B3
25,716
100.00%
2
2
11
CATA_HUMAN CAT
59,739
100.00%
4
4
8
Olfactomedin-like protein 2A
OLM2A_HUMAN OLFML2A
73,037
100.00%
4
4
51
Gelsolin
GELS_HUMAN GSN
85,680
100.00%
28
41
685
SSB
TLLFSGNQVWR 12.80% DLTGELEYATK GLAYGLYLR VFYIGLR 6.70% FGNQADHFLGSLAFAK VISLEDFMEK 19.20% AVENYLIQMAR NSILAQVLDQSAR 14.20% AAPTAASDQPDSAATTEK IQAGEVSQPSK 8.48% ALGTEVIQLFPEK ELWFSDDPNVTK SATEQSGTGIR VMPNAIVQSVGVSSGK 23.90% LVVLDEELEGISPDELKDELPER NTEDLTEEWLR 19.90% EVTWEVLEGEVEK GSIFVVFDSIESAK IIEDQQESLNK LDEGWVPLEIMIK NKEVTWEVLEGEVEK QKLEEDAEMK SPSKPLPEVTDEYKNDVK 7.79% AIVQLVNER VVVLGLLPR 11.40% ADVLTTGAGNPVGDKLNVITVGPR AFYVNVLNEEQR FNTANDDNVTQVR LSQEDPDYGIR 6.75% LDPGDLSVHR LGLQLLQK SNSAEPNSAEQDEAEPR VFGDLDQVR 43.20% AGALNSNDAFVLK AGKEPGLQIWR AQPVQVAEGSEPDGFWEALGGK
AVEVLPK DPDQTDGLGLSYLSSHIANVER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
56.6 69.4 71.4 61.1 44.3 39.4 55.9 48.5 30.0 65.2 34.8 27.2 54.0 56.5 30.3 45.7 39.8 48.4 38.8 40.3 69.2 139.0 44.1 38.2 33.4 59.8 49.9 64.2 63.8 57.3 68.4 70.6 44.4 27.8 39.0 39.6 45.2 71.8 50.0 71.1 72.0 40.2 58.1 54.5 136.0 56.9 84.6 57.0 117.0 56.8 121.0
21.2 23.0 22.4 20.1 21.2 21.9 21.7 23.1 17.6 25.3 22.9 21.8 18.5 22.8 22.6 19.0 19.7 22.7 22.8 22.7 21.7 20.4 22.0 20.1 21.2 23.1 22.8 21.4 21.5 22.4 21.6 23.6 21.8 22.4 21.7 22.0 20.0 3.0 17.2 22.3 22.4 22.1 22.3 13.0 15.4 24.0 23.0 19.8 21.4 14.5 21.7
4 3 2 2 2 2 2 4 1 2 1 0 0 4 1 4 2 0 1 1 1 4 2 3 1 4 2 0 1 4 8 6 2 0 0 0 2 9 0 2 2 2 4 4 39 4 66 3 53 20 2
0 0 0 0 0 1 0 0 0 0 0 1 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 1 2 2 0 0 2 0 0 0 0 0 0 0 0 26 5 0 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,428.68 1,501.77 1,225.62 1,340.74 1,128.66 1,283.67 1,094.55 1,689.82 1,095.47 1,778.83 1,163.56 2,137.07 2,987.34 1,320.71 1,239.61 1,025.58 867.51 1,722.86 1,210.60 1,307.68 1,414.77 1,731.80 1,143.60 1,444.81 1,450.69 1,106.54 1,588.84 2,637.35 1,405.66 1,546.76 1,498.78 1,316.67 1,542.82 1,788.90 1,236.58 2,046.04 1,041.61 965.65 2,364.29 1,481.74 1,493.70 1,292.61 1,108.58 912.59 1,830.77 1,048.54 1,319.70 1,254.70 2,272.09 755.47 2,387.15
Table S1 page 42/159
DSQEEEKTEALTSAK EPGLQIWR EVQGFESATFLGYFK GASQAGAPQGR GGVASGFK HVVPNEVVVQR KGGVASGFK LKATQVSK NWRDPDQTDGLGLSYLSSHIANVER
QTQVSVLPEGGETPLFK RTPITVVK SEDCFILDHGK SEDCFILDHGKDGK TASDFITK TGAQELLR TPITVVK TPSAAYLWVGTGASEAEK VHVSEEGTEPEAMLQVLGPKPALPAGTEDTAK VHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANR
VPEARPNSMVVEHPEFLK VPFDAATLHTSTAMAAQHGMDDDGTGQK
VSNGAGTMSVSLVADENPFAQGALK
Peptidyl-prolyl cis-trans isomerase A PPIA_HUMAN PPIA
17,995
100.00%
13
17
257
YIETDPANR 72.70% ALSTGEK EGMNIVEAMER FEDENFILK HTGPGILSMANAGPNTNGSQFFICTAK
GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 Transcription intermediary factor 1- TIF1B_HUMAN TRIM28 beta
25,189
100.00%
2
2
3
11.10%
88,531
100.00%
3
3
9
6.23%
26S proteasome non-ATPase regulatory subunit 3
PSMD3_HUMAN PSMD3
60,962
100.00%
6
6
8
14.40%
Proprotein convertase subtilisin/kexin type 9
PCSK9_HUMAN PCSK9
74,353
100.00%
19
26
261
35.00%
IIPGFMCQGGDFTR MVNPTVFFDIAVDGEPLGR SIYGEKFEDENFILK TEWLDGK TEWLDGKHVVFGK VKEGMNIVEAMER VNPTVFFDIAVDGEPLGR VSFELFADK VSFELFADKVPK ATADDELSFK ESESAPGDFSLSVK IVAERPGTNSTGPAPMAPPR LDLDLTADSQPPVFK LSPPYSSPQEFAQDVGR AVQGFFTSNNATR FNQVLDQFGEK LQLDSPEDAEFIVAK SLMPYFLLTQAVR SVFPEQANNNEWAR TAAAAAEHSQR AGVVLVTAAGNFR AHNAFGGEGVYAIAR CAPDEELLSCSSFSR DVINEAWFPEDQR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
101.0 37.9 110.0 69.2 43.4 57.0 47.9 38.1 72.8 91.1 31.0 65.6 27.1 46.1 74.2 35.2 122.0 70.1 48.7 61.4 65.3 113.0 48.1 35.6 58.7 56.8 76.5 88.7 138.0 82.9 41.3 29.4 86.5 106.0 65.3 66.9 30.5 49.4 53.6 69.6 84.4 90.8 49.1 39.1 30.1 38.8 61.7 48.4 79.6 94.7 74.4
22.8 20.8 22.3 20.8 22.5 20.5 21.0 17.8 21.2 21.2 17.0 19.6 19.6 20.8 23.7 14.9 22.4 19.6 19.2 21.9 18.5 21.9 23.0 26.1 21.3 21.7 21.5 22.0 22.6 22.6 23.0 22.3 22.7 21.5 21.4 20.3 22.4 22.1 22.5 22.0 23.1 22.2 22.3 22.9 19.8 21.0 21.1 19.7 22.5 16.8 21.0
38 3 95 11 7 20 2 2 0 61 2 3 0 2 18 2 116 0 0 0 0 4 9 1 15 6 0 7 13 37 14 0 21 38 30 19 1 2 0 2 3 1 1 2 1 1 2 8 9 2 22
18 0 0 0 0 11 0 0 6 1 0 1 1 0 0 0 1 5 0 10 20 7 0 0 0 0 4 0 0 4 0 1 12 22 0 13 0 0 4 0 0 0 0 0 0 0 0 0 12 0 0
0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 2 5 1 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,665.78 998.54 1,722.84 999.50 722.38 1,275.72 850.48 874.54 2,843.37 1,829.97 913.58 1,320.59 1,620.73 882.46 887.50 757.48 1,837.90 3,317.66 3,957.95 2,095.06 2,889.28 2,479.21 1,078.52 705.38 1,278.58 1,154.57 2,791.33 1,598.75 2,077.04 1,831.91 848.42 1,515.80 1,505.75 1,946.00 1,055.54 1,379.76 1,096.52 1,452.69 2,035.04 1,658.86 1,877.90 1,412.69 1,324.65 1,674.86 1,538.84 1,661.77 1,112.54 1,274.72 1,532.76 1,757.75 1,618.75
Table S1 page 43/159
GTVSGTLIGLEFIR HLAQASQELQ ILHVFHGLLPGFLVK LPGTYVVVLK LPGTYVVVLKEETHLSQSER LQAQAAR MATAIAR MSGDLLELALK RLQAQAAR SEEDGLAEAPEHGTTATFHR SQLVQPVGPLVVLLPLAGGYSR TVWSAHSGPTR VLNAACQR VLTPNLVAALPPSTHGAGWQLFCR
Proteasome subunit alpha type-4
PSA4_HUMAN PSMA4
29,467
100.00%
9
10
49
VMVTDFENVPEEDGTR 36.80% ATCIGNNSAAAVSMLK EGEMTLK LLDEVFFSEK LNEDMACSVAGITSDANVLTNELR
Deoxyribonuclease-2-alpha
DNS2A_HUMAN DNASE2
39,563
99.90%
2
2
5
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
DDAH2_HUMAN DDAH2
29,626
100.00%
6
7
12
LSAEKVEIATLTR QAYTQFGGK SALALAIK TTIFSPEGR VEIATLTR 6.11% ALINSPEGAVGR YLDESSGGWR 33.70% DFAVSTVPVSGPSHLR GAEIVADTFR GGGDLPNSQEALQK GVPESLASGEGAGAGLPALDLAK
Peptidyl-prolyl cis-trans isomerase B PPIB_HUMAN PPIB
Beta-1,3-Nacetylglucosaminyltransferase Thioredoxin
23,725
100.00%
13
17
92
LFNG_HUMAN LFNG
41,756
99.90%
2
3
11
THIO_HUMAN TXN
11,719
100.00%
6
6
22
IVEIGDENATLDGTDVLFTGR TVVAGSSDAAQK 54.60% DFMIQGGDFTR DKPLKDVIIADCGK DTNGSQFFITTVK FPDENFK HYGPGWVSMANAGK IEVEKPFAIAK IEVEKPFAIAKE IGDEDVGR SIYGERFPDENFK TVDNFVALATGEK VIFGLFGK VIKDFMIQGGDFTR VLEGMEVVR 5.28% GPFSVEADPSR LLASYPHTR 42.90% EKLEATINELV LEATINELV MIKPFFHSLSEK TAFQEALDAAGDK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
62.4 52.4 46.2 38.2 34.7 45.8 44.8 88.1 44.4 79.3 108.0 59.0 43.5 29.5 108.0 80.9 31.1 75.0 128.0 77.6 34.3 62.0 42.0 54.7 64.5 76.3 50.8 51.6 52.2 102.0 129.0 64.5 51.0 68.5 96.1 32.9 75.9 42.3 70.6 50.4 53.6 98.9 52.6 91.2 56.4 67.1 45.0 49.1 35.8 65.2 99.2
19.4 22.4 7.8 12.8 19.6 19.4 24.2 23.0 20.5 20.5 10.4 22.3 24.2 19.4 20.8 22.7 21.0 22.6 21.5 18.5 20.8 17.9 23.3 20.5 21.4 21.4 21.5 23.6 22.5 21.0 22.6 23.1 19.3 20.9 22.0 20.6 21.4 17.3 20.4 20.2 22.0 22.8 18.7 22.4 23.1 22.1 22.1 22.7 23.6 22.6 22.6
22 7 0 3 0 2 6 12 1 2 68 8 3 0 25 4 1 15 2 2 1 9 8 4 3 2 2 2 2 2 2 1 5 2 4 2 4 2 7 2 2 20 13 4 9 5 4 8 1 4 4
2 0 7 0 4 0 0 0 0 2 19 0 0 3 0 0 0 0 0 3 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 4 0 4 0 0 0 0 7 0 0 2 0 0 0 0
0 0 9 0 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,462.83 1,124.57 1,690.02 1,088.67 2,285.21 757.43 749.40 1,189.65 913.53 2,154.97 2,263.32 1,198.60 931.48 2,605.37 1,837.83 1,623.78 823.39 1,226.63 2,609.22 1,430.82 999.49 786.51 1,007.52 902.53 1,183.64 1,169.52 1,668.87 1,078.55 1,413.70 2,080.09 2,235.11 1,133.58 1,286.58 1,571.85 1,457.73 896.42 1,474.69 1,244.73 1,373.77 860.41 1,601.76 1,364.71 880.53 1,642.83 1,031.56 1,161.55 1,057.58 1,258.69 1,001.55 1,479.77 1,336.64
Table S1 page 44/159
TNPO1_HUMAN TNPO1
102,341
100.00%
3
3
3
4.68%
Serine/threonine-protein phosphatase PPP5_HUMAN PPP5C 5
56,862
100.00%
9
9
16
23.80%
Small nuclear ribonucleoprotein Sm SMD1_HUMAN SNRPD1 D1 Guanine nucleotide-binding protein GBG12_HUMAN GNG12 G(I)/G(S)/G(O) subunit gamma-12 PAPL_HUMAN PAPL Iron/zinc purple acid phosphataselike protein
13,264
99.50%
2
3
8
27.70%
7,989
99.50%
2
2
2
37.50%
50,462
100.00%
3
3
6
10.00%
Transportin-1
Ephrin-B1
EFNB1_HUMAN EFNB1
37,989
100.00%
6
8
38
24.60%
L-lactate dehydrogenase A chain
LDHA_HUMAN LDHA
36,671
100.00%
14
16
150
38.60%
Nidogen-2
NID2_HUMAN NID2
151,235
100.00%
19
20
147
17.10%
VGEFSGANK VGEFSGANKEK ESQSPDTTIQR GDVEEDETIPDSEQDIRPR QSSFALLGDLTK AALRDYETVVK AASNMALGK AEGYEVAHGGR AFLEENNLDYIIR AIAGDEHKR AIELDKK FYSQAIELNPSNAIYYGNR GNHETDNMNQIYGFEGEVK SVVDSLDIESMTIEDEYSGPK NREPVQLETLSIR YFILPDSLPLDTLLVDVEPK SDPLLIGIPTSENPFK TASTNNIAQAR AQGTFVPFVDGGILR LAVFGDLGADNPK SEVQFGLQPSGPLPLR AEAGRPYEYYK FQEFSPNYMGLEFK GGSGTAGTEPSDIIIPLR GSLGDSDGKHETVNQEEK IGDKLDIICPR NLEPVSWSSLNPK DLADELALVDVIEDK DQLIYNLLK DQLIYNLLKEEQTPQNK DYNVTANSK FIIPNVVK GEMMDLQHGSLFLR KSADTLWGIQK LNLVQR LVIITAGAR NVNIFK QVVESAYEVIK SADTLWGIQK VIGSGCNLDSAR VTLTSEEEAR AGLELGAEPETIVNSGLISPEGLAIDHIR
AIAVDPIR DGVVSVNK EDTSPAVLGLAAR ELYHYSDSTVTSTSSR ESYNVQLQLPAR GEADDLKSEGPYFSLTSTEQSVK
GNLYWTDWNR HAQAQYAYPGAR HPSFPTTQQLNVDR
95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
56.0 37.8 30.1 40.7 60.1 37.3 39.6 41.2 89.2 38.5 39.4 115.0 41.3 118.0 53.8 87.8 30.5 49.0 73.9 45.9 54.2 30.5 73.7 47.0 43.5 42.1 89.0 106.0 64.7 76.1 62.2 36.9 43.2 35.2 48.6 73.5 31.4 56.5 64.5 73.9 66.1 48.4 31.6 38.5 73.1 72.8 57.1 37.0 36.9 54.1 53.7
22.5 23.5 22.2 20.5 21.9 20.8 23.4 19.8 21.9 21.0 22.6 21.8 17.1 19.8 20.0 17.0 21.1 23.5 21.1 23.4 19.7 21.9 21.1 21.8 20.0 21.1 22.7 21.3 20.4 21.9 20.6 17.9 22.0 21.7 18.8 17.0 22.0 21.8 23.0 21.7 23.7 17.7 18.7 24.1 21.3 20.6 22.5 20.3 21.4 23.2 22.5
3 2 1 0 1 1 2 1 4 1 2 2 0 2 2 4 1 1 3 1 2 1 8 2 1 1 12 25 6 2 2 3 4 2 25 22 1 4 11 3 34 0 1 2 16 4 9 0 4 14 0
0 0 0 1 0 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 6 7 0 0 0 2 0 0 4 0 0 0 0 0 0 0 0 2 0 0 0 1 0 2 0 0 16
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
908.45 1,165.59 1,261.60 2,200.00 1,279.69 1,264.69 878.44 1,145.53 1,609.82 996.52 816.48 2,220.07 2,197.95 2,330.06 1,554.86 2,287.25 1,727.92 1,146.59 1,576.85 1,316.69 1,724.93 1,346.64 1,752.79 1,740.91 1,929.88 1,299.71 1,470.76 1,657.85 1,119.64 2,074.08 1,011.47 929.58 1,649.78 1,246.68 742.46 913.58 734.42 1,264.68 1,118.58 1,248.60 1,134.56 2,971.57 854.51 817.44 1,299.69 1,832.83 1,417.74 2,488.17 1,324.61 1,332.64 1,639.82
Table S1 page 45/159
Nucleophosmin
NPM_HUMAN NPM1
32,557
100.00%
9
10
143
HSGQFTDEYLPEQR IETSSLDGENRR ITQTAEGLDPENYLSIK KVLFYTDLVNPR LANPLHFYEAR MVYWTDVAGR SEGPYFSLTSTEQSVK VFALYNDEER VLFYTDLVNPR VLYREDTSPAVLGLAAR 38.80% GPSSVEDIK LLSISGK MQASIEK MSVQPTVSLGGFEITPPVVLR MTDQEAIQDLWQWR SKGQESFK TVSLGAGAKDELHIVEAEAMNYEGSPIK
Collagen alpha-6(IV) chain
CO4A6_HUMAN COL4A6
163,794
100.00%
3
3
7
2.25%
Tropomodulin-3
TMOD3_HUMAN TMOD3
39,578
99.90%
2
2
6
7.10%
Aspartyl aminopeptidase
DNPEP_HUMAN DNPEP
52,411
100.00%
3
3
4
4.84%
Xaa-Pro dipeptidase
PEPD_HUMAN PEPD
54,530
100.00%
6
6
29
14.40%
Filamin-B
FLNB_HUMAN FLNB
278,141
100.00%
83
99
1267
41.70%
VDNDENEHQLSLR VTLATLK GDSGSQGFR GNPGPVGIPSPR GPMGSEGVQGPPGQQGK FGYQFTQQGPR SNDPVATAFAEMLK VKVPLQDLMVR VPLQDLMVR YASNAVSEALIR AVYEAVLR FEVNNTILHPEIVECR KNPAVQAGSIVVLQGGEETQR STLFVPR TDMELEVLR VPLALFALNR AAGSGELGVTMK ADIEMPFDPSK AEVSIQNNK AGGPGLER AGLAPLEVR AGPGTLSVTIEGPSK AHGPGLEGGLVGKPAEFTIDTK APLNVQFNSPLPGDAVK APSVATVGSICDLNLK AWGPGLHGGIVGR CLATGPGIASTVK DAGEGLLAVQITDQEGKPK DAGYGGISLAVEGPSK DGTYAVTYIPDK DGTYAVTYVPLTAGMYTLTMK DLAEDAPWK DLAEDAPWKK DLDIIDNYDYSHTVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
69.7 29.0 121.0 79.4 51.2 54.0 96.3 57.1 64.7 35.6 67.2 44.5 40.3 126.0 86.8 34.3 69.0 89.0 37.8 48.9 39.2 79.3 50.3 63.4 30.4 37.8 46.1 33.9 43.4 61.1 33.8 63.4 87.8 70.7 73.7 41.1 79.5 49.7 70.1 36.9 79.2 106.0 48.6 60.6 65.0 55.8 41.7 40.9 31.6 40.9 81.1
21.9 21.8 22.0 18.3 23.2 22.0 21.6 21.2 20.8 19.4 21.7 22.0 22.8 19.2 24.6 21.5 21.1 21.7 15.1 19.3 22.8 21.0 22.4 23.2 19.1 22.7 22.9 21.0 21.7 19.0 20.5 23.7 16.9 23.0 19.9 22.9 20.7 17.9 22.1 19.0 21.3 21.6 22.7 23.6 21.6 23.0 21.7 21.3 20.5 22.5 21.0
3 0 29 1 4 7 6 17 10 1 31 1 7 49 26 1 0 15 5 1 2 4 2 4 0 2 1 1 0 0 3 3 18 24 30 5 30 15 18 0 35 2 2 7 5 3 3 1 1 2 18
0 2 0 0 0 0 0 0 0 0 0 0 0 6 0 0 2 0 0 0 0 0 0 0 1 0 0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,706.78 1,376.68 1,891.97 1,464.82 1,330.69 1,197.57 1,759.84 1,255.60 1,336.73 1,831.01 931.47 717.45 822.40 2,243.21 1,835.84 910.46 2,929.46 1,568.73 745.48 910.40 1,147.62 1,626.76 1,328.64 1,493.73 1,313.76 1,086.60 1,293.68 920.52 1,969.98 2,181.16 819.47 1,121.55 1,113.68 1,136.56 1,265.57 1,002.52 756.40 925.55 1,413.76 2,194.15 1,766.94 1,644.86 1,276.69 1,274.68 1,969.02 1,520.76 1,342.65 2,328.11 1,044.50 1,172.60 1,810.85
Table S1 page 46/159
EAFTNKPNVFTVVTR EAGAGGLSIAVEGPSK EATTDFTVDSRPLTQVGGDHIK FADEHVPGSPFTVK FNDEHIPESPYLVPVIAPSDDAR FNGSHVVGSPFK FVPQEMGVHTVSVK GAGIGGLGITVEGPSESK GEAGVPAEFSIWTR GIEPTGNMVK GLEELVK GLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVK
GQHVTGSPFQFTVGPLGEGGAHK
HVGNQQYNVTYVVK IAGPGLGSGVR IFAQDGEGQR IFFAGDTIPK IGNLQTDLSDGLR IKVFGPGIEGK IPEINSSDMSAHVTSPSGR IPYLPITNFNQNWQDGK IQQNTFTR KGEITGEVHMPSGK LDVTILSPSR LDVTILSPSRK LIALLEVLSQK LKPGAPLKPK LLGWIQNK LNGLENR LPNNHIGISFIPR LTVMSLQESGLK LVSPGSANETSSILVESVTR NTVELLVEDK NTVELLVEDKGNQVYR SPFEVQVGPEAGMQK SPFEVSVDK SPFTVGVAAPLDLSK TATPEIVDNKDGTVTVR TFEMSDFIVDTR TGEEVGFVVDAK TYSVEYLPK VDPSHDASK VEVGKDQEFTVDTR VFGPGIEGK VKAEGPGLSK VKVDPSHDASK VKVEPAVDTSR VLFASQEIPASPFR VLQSFTVDSSK VLSEDEEDVDFDIIHNANDTFTVK
VMYTPMAPGNYLISVK
95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
63.6 80.8 52.5 41.6 36.7 26.4 65.5 85.3 75.9 37.8 31.9 90.7 43.6 52.0 79.6 63.3 59.8 72.4 46.6 98.2 82.1 42.6 40.4 77.0 32.4 65.7 32.5 65.3 44.8 44.3 58.7 129.0 32.6 33.3 86.5 41.2 101.0 79.9 92.5 46.2 41.8 35.2 87.8 37.5 34.6 27.5 45.3 85.8 69.1 31.5 74.2
20.9 22.5 21.7 22.1 21.4 22.9 23.6 22.0 23.6 22.4 21.8 19.2 21.8 23.3 18.8 22.9 21.2 22.5 18.6 22.0 22.6 22.3 21.8 22.7 18.7 13.4 0.0 22.2 21.5 17.7 22.5 21.3 24.0 21.8 22.1 21.8 21.5 20.9 21.1 22.6 22.3 20.1 22.9 22.7 18.6 21.9 22.3 22.5 22.5 20.5 22.4
11 7 0 3 1 0 6 25 17 5 1 0 0 2 29 52 55 17 0 6 31 12 1 17 0 17 0 37 2 0 8 35 1 0 36 7 57 7 19 15 3 1 12 2 4 0 3 38 6 0 21
43 0 12 6 3 1 0 0 0 0 0 10 4 0 0 0 0 0 9 20 0 0 4 0 1 0 3 0 0 10 0 3 0 3 0 0 0 2 0 0 0 0 13 0 0 1 14 0 0 1 0
0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,722.92 1,442.75 2,387.18 1,530.76 2,581.26 1,275.65 1,573.80 1,628.85 1,519.75 1,061.53 787.46 3,505.68 2,308.15 1,648.84 983.56 1,120.54 1,108.60 1,401.73 1,144.67 1,984.94 2,048.02 1,007.53 1,485.74 1,100.63 1,228.73 1,226.77 1,048.69 971.57 815.44 1,477.83 1,321.70 2,046.07 1,159.62 1,876.98 1,603.78 1,007.51 1,501.83 1,815.95 1,460.67 1,250.63 1,099.57 955.45 1,622.80 903.49 985.57 1,182.61 1,200.66 1,561.84 1,210.63 2,765.28 1,799.91
Table S1 page 47/159
VNIGQGSHPQK VNQPASFAIR VPVKDVVDPSK VQAQGPGLK VSYFPTVPGVYIVSTK VTASGPGLSSYGVPASLPVDFAIDAR
VTEAEIVPMGK VVASGPGLEHGK VVPCLVTPVTGR YADEEIPR YGGELVPHFPAR YGGPNHIVGSPFK YMIGVTYGGDDIPLSPYR YTPTQQGNMQVLVTYGGDPIPK
Echinoderm microtubule-associated EMAL2_HUMAN EML2 protein-like 2
70,659
100.00%
5
5
11
Heterogeneous nuclear ribonucleoprotein D0
HNRPD_HUMAN HNRNPD
38,417
100.00%
8
10
116
Single-stranded DNA-binding protein, mitochondrial Endoplasmic reticulum resident protein 44
SSBP_HUMAN SSBP1
17,242
99.50%
2
2
5
ERP44_HUMAN ERP44
46,955
100.00%
3
3
6
Ubiquitin-conjugating enzyme E2 N UBE2N_HUMAN UBE2N
17,121
100.00%
3
3
5
Transcriptional activator protein Pur- PURA_HUMAN PURA alpha CYTN_HUMAN CST1 Cystatin-SN
34,893
100.00%
2
2
3
16,344
99.50%
2
2
3
8.63% DGTLVSGGGR IIEDPAR LQEVEVPEDFGPVR QITSADAVR TVAEGHGDTLYVGTTR 26.50% ESESVDKVMDQK EYFGGFGEVESIELPMDNK FGEVVDCTLK GFGFVLFK IDASKNEEDEGHSNSSPR IFVGGLSPDTPEEK MFIGGLSWDTTK MFIGGLSWDTTKK 20.30% NPVTIFSLATNEMWR SGDSEVYQLGDVSQK 7.88% DLAEITTLDR SDPIQEIR TPADCPVIAIDSFR 23.70% LELFLPEEYPMAAPK LLAEPVPGIK TNEAQAIETAR 11.20% IAEVGAGGNK LIDDYGVEEEPAELPEGTSLTVDNKR
Ceruloplasmin
CERU_HUMAN CP
122,190
100.00%
9
9
29
Beta-2-microglobulin
B2MG_HUMAN B2M
13,697
100.00%
5
10
224
24.80% IIPGGIYNADLNDEWVQR QQTVGGVNYFFDVEVGR 11.50% ALYLQYTDETFR DIASGLIGPLIICK DIFTGLIGPMK EYTDASFTNR GAYPLSIEPIGVR MFTTAPDQVDKEDEDFQESNK NNEGTYYSPNYNPQSR QSEDSTFYLGER VNKDDEEFIESNK 42.90% IEKVEHSDLSFSK IQVYSR SNFLNCYVSGFHPSDIEVDLLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
44.6 70.9 64.6 52.9 58.5 52.0 77.4 78.2 45.7 52.8 41.9 59.3 62.4 92.5 61.7 35.8 85.5 34.8 74.3 43.1 73.6 55.7 40.5 68.2 91.8 71.1 32.9 81.9 100.0 50.1 31.9 37.0 32.4 34.7 54.5 46.8 67.1 89.7 33.1 66.1 53.3 33.7 51.8 56.2 38.4 71.4 69.1 88.5 92.9 39.4 44.9
22.2 23.5 19.4 17.6 20.3 20.3 23.3 22.5 19.3 22.1 22.1 22.3 21.0 21.2 23.9 19.7 22.1 24.0 22.4 21.8 20.2 22.7 22.9 18.9 23.0 22.4 22.1 22.4 21.4 23.8 20.8 22.8 22.4 11.8 23.2 21.6 21.3 22.4 21.6 23.4 19.3 23.0 17.0 22.0 15.7 17.5 20.2 21.3 23.0 21.9 21.4
13 25 17 13 30 6 24 22 6 7 3 4 6 9 3 1 4 1 2 4 7 13 13 3 45 6 2 3 2 4 1 1 1 2 2 2 0 2 1 2 2 1 3 9 0 4 2 4 5 12 7
13 0 0 0 0 0 0 21 0 0 30 2 0 0 0 0 0 0 0 2 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 0 0 0 3 0 37
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,164.61 1,102.60 1,182.67 897.52 1,756.95 2,547.31 1,173.62 1,150.62 1,297.73 992.47 1,342.69 1,372.70 2,032.97 2,423.19 918.46 813.45 1,613.82 960.51 1,676.82 1,394.65 2,176.98 1,167.57 914.51 1,971.86 1,488.76 1,355.67 1,499.76 1,778.89 1,611.75 1,146.60 957.50 1,561.77 1,763.89 1,036.64 1,203.60 915.49 2,889.40 2,073.04 1,914.94 1,519.74 1,469.84 1,207.64 1,203.53 1,371.76 2,490.06 1,903.82 1,431.64 1,566.73 1,518.78 765.43 2,554.23
Table S1 page 48/159
Adenosylhomocysteinase
SAHH_HUMAN AHCY
47,699
100.00%
18
24
142
39.60%
Aspartyl-tRNA synthetase, cytoplasmic
SYDC_HUMAN DARS
57,119
100.00%
5
5
10
14.20%
Nuclear migration protein nudC
NUDC_HUMAN NUDC
38,226
100.00%
8
8
20
27.50%
Procollagen-lysine,2-oxoglutarate 5- PLOD3_HUMAN PLOD3 dioxygenase 3
84,769
100.00%
16
16
77
27.00%
269,747
100.00%
6
6
11
3.19%
Talin-1
TLN1_HUMAN TLN1
VEHSDLSFSK VNHVTLSQPK AGIPVYAWK ALDIAENEMPGLMR ATDVMIAGK DGPLNMILDDGGDLTNLIHTK ESLIDGIK ESLIDGIKR GISEETTTGVHNLYK IILLAEGR KALDIAENEMPGLMR KLDEAVAEAHLGK LDEAVAEAHLGK VADIGLAAWGR VAVVAGYGDVGK VNIKPQVDR VPAINVNDSVTK WLNENAVEK YPQLLPGIR YPVGVHFLPK ATVNQDTR EAGVEMGDEDDLSTPNEK FGAPPHAGGGIGLER IYVISLAEPR LPLQLDDAVRPEAEGEEEGR ELTDEEAER FMDQHPEMDFSK GQPAIIDGELYNEVK LKPNLGNGADLPNYR LSDLDSETR LVSSDPEINTK SETSGPQIK SMGLPTSDEQK AVMNFVVR DVFSGSDTDPDMAFCK IFQNLNGALDEVVLK KFVQSGSR LAGGYENVPTVDIHMK LLLLDYPPDR LSLNLDHK LVGPEEALSPGEAR LYLDPGLR NVAYDTLPIVVHGNGPTK QVGYEDQWLQLLR SEDYVELVQR TLGLGEEWR TYVGPMTESLFPGYHTK VGVWNVPYISQAYVIR YKDDDDDQLFYTR AVAEQIPLLVQGVR GLAGAVSELLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
60.7 59.6 42.1 77.5 35.1 111.0 41.5 40.9 80.5 41.5 71.3 91.3 59.9 93.8 73.9 33.1 76.6 50.6 51.3 40.6 34.7 40.6 44.9 52.1 36.1 55.5 44.4 75.5 27.0 36.0 61.6 48.3 34.9 71.5 51.7 124.0 38.1 38.5 56.1 31.7 95.0 53.6 69.0 55.4 70.9 55.4 50.8 59.7 75.3 39.6 46.0
23.1 20.3 22.9 22.4 24.0 22.6 23.6 20.9 23.2 16.3 22.1 21.4 22.1 22.3 22.7 18.7 22.2 22.6 20.4 21.0 23.1 14.9 22.3 19.7 22.4 19.2 12.3 22.0 21.2 22.4 23.9 23.8 21.0 22.8 14.1 19.6 21.1 22.1 22.3 17.4 21.9 21.7 21.0 22.9 22.2 25.1 22.2 19.3 19.9 14.5 21.2
30 46 1 11 1 4 1 3 7 6 2 2 2 13 4 1 15 7 17 2 3 1 0 2 0 6 2 2 0 2 3 1 3 4 1 5 1 0 17 1 13 4 3 5 6 4 1 5 1 1 4
17 58 0 0 0 29 0 0 1 0 4 3 2 0 0 0 0 0 0 4 0 0 2 0 2 0 0 0 1 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,148.56 1,122.63 1,004.56 1,575.75 905.48 2,268.12 874.49 1,030.59 1,648.82 884.56 1,719.84 1,380.75 1,252.65 1,128.62 1,134.62 1,068.62 1,256.69 1,102.55 1,056.62 1,156.65 904.45 1,951.81 1,435.74 1,160.67 2,223.09 1,091.49 1,543.62 1,645.84 1,641.87 1,035.50 1,202.63 946.48 1,208.55 935.51 1,791.72 1,672.93 908.50 1,743.87 1,214.68 939.53 1,424.74 946.54 1,895.00 1,647.85 1,237.61 1,060.54 1,927.93 1,864.01 1,693.73 1,492.89 1,085.63
Table S1 page 49/159
ILAQATSDLVNAIK LNEAAAGLNQAATELVQASR NLGTALAELR VLVQNAAGSQEK ESEDFIVEQYK GVLLMLFGGVPK IQETQAELPR ISGQVVR SELVNWYLK TSILAAANPISGHYDR TANEGGSLLYEQLGYK YELPLVIQALTNIEDK ALESSIAPIVIFASNR AVLLAGPPGTGK GLGLDESGLAK GTEDITSPHGIPLDLLDR LDPSIFESLQK QAASGLVGQENAR YSVQLLTPANLLAK MTELETAMGMIIDVFSR YSGSEGSTQTLTK APVDITGQFEK DNILPELGVR FEDHEGLPTVVK IQHAVQLATEPLEK WGEEEAELNK LAEMPADSGYPAYLGAR TALVANTSNMPVAAR ATAPQTQHVSPMR FYEQMNGPVAGASR GVVQELQQAISK IASLEVENQSLR KPALVAK LVPVGYGIR SIQLDGLVWGASK
DNA replication licensing factor MCM6
MCM6_HUMAN MCM6
92,873
100.00%
6
6
8
7.92%
Sodium-coupled neutral amino acid transporter 2 RuvB-like 1
S38A2_HUMAN SLC38A2
56,011
99.50%
2
2
4
6.32%
RUVB1_HUMAN RUVBL1
50,211
100.00%
7
8
22
20.80%
Protein S100-P
S100P_HUMAN S100P
10,382
99.50%
2
2
10
31.60%
Cysteinyl-tRNA synthetase, cytoplasmic
SYCC_HUMAN CARS
85,458
100.00%
5
5
8
7.62%
V-type proton ATPase catalytic subunit A Elongation factor 1-delta
VATA_HUMAN ATP6V1A
68,287
100.00%
2
2
4
5.19%
EF1D_HUMAN EEF1D
31,104
100.00%
8
10
63
37.00%
14-3-3 protein eta
1433F_HUMAN YWHAH
28,202
100.00%
9
10
41
58.90% AVTELNEPLSNEDR AVTELNEPLSNEDRNLLSVAYK DNLTLWTSDQQDEEAGEGN DSTLIMQLLR ELETVCNDVLSLLDK KNSVVEASEAAYK LAEQAER MKGDYYR NLLSVAYK NLLSVAYKNVVGAR NSVVEASEAAYK QAFDDAIAELDTLNEDSYK VISSIEQK YDDMASAMK YLAEVASGEKK
SLAGSSGPGASSGTSGDHGELVVR
95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
49.6 84.8 47.1 40.0 32.0 30.0 61.6 46.3 38.6 26.2 107.0 96.1 71.9 33.0 45.4 39.5 50.7 57.9 55.1 77.8 97.0 39.0 32.9 31.5 39.9 45.6 50.9 93.9 44.4 90.3 79.0 90.1 39.0 47.2 82.6 108.0 86.6 32.5 32.5 79.3 96.4 53.8 59.4 42.7 51.4 79.1 71.3 113.0 65.9 53.8 46.7
17.9 20.8 21.6 22.2 21.2 18.4 22.3 23.8 22.4 22.1 22.3 19.9 19.8 16.7 23.1 22.3 23.2 22.1 16.2 20.4 21.8 23.1 20.8 21.8 20.2 20.2 21.8 23.3 23.4 20.5 20.9 22.1 12.0 19.5 22.0 21.3 22.5 20.8 15.6 21.3 22.6 22.5 21.6 19.2 19.1 17.7 22.3 21.6 22.9 9.5 21.2
2 1 2 1 1 1 2 1 2 0 2 2 6 1 1 0 2 3 2 4 6 2 1 0 0 2 2 2 7 9 13 10 1 4 8 1 4 0 1 113 6 2 36 6 49 4 7 4 27 9 4
0 0 0 0 0 0 0 0 0 1 0 0 3 0 0 4 0 0 0 0 0 0 0 2 1 0 0 0 2 0 0 0 0 0 0 8 0 3 0 0 0 0 0 0 0 2 0 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,456.84 2,027.05 1,057.60 1,243.66 1,386.64 1,246.72 1,184.63 758.45 1,151.61 1,685.86 1,742.86 1,859.02 1,687.94 1,080.64 1,059.57 1,949.00 1,276.68 1,300.66 1,530.89 1,991.91 1,358.64 1,204.62 1,125.63 1,370.70 1,576.87 1,204.55 1,797.85 1,531.79 1,439.71 1,542.70 1,299.73 1,358.73 726.49 973.58 1,373.74 2,185.05 1,586.77 2,475.27 2,121.89 1,189.66 1,747.88 1,395.71 816.42 932.43 907.53 1,503.86 1,267.62 2,157.98 903.52 1,063.41 1,194.64
Table S1 page 50/159
Early endosome antigen 1
EEA1_HUMAN EEA1
162,450
100.00%
5
5
12
Protein S100-A8
S10A8_HUMAN S100A8
10,817
99.50%
2
2
9
43,045
100.00%
7
9
27
Interleukin enhancer-binding factor 2 ILF2_HUMAN ILF2
Ephrin type-B receptor 4
EPHB4_HUMAN EPHB4
108,252
99.50%
2
2
2
Pyruvate kinase isozymes M1/M2
KPYM_HUMAN PKM2
57,920
100.00%
38
50
933
3.90% AAQLATEIADIK IQNLEALLQK ITTQLDQVTAK LSASETSLHR LSLAQEDLISNR 23.70% ALNSIIDVYHK LLETECPQYIR 23.80% ILITTVPPNLR ILPTLEAVAALGNK NQDLAPNSAEQASILSLVTK QPLALNVAYR VKPAPDETSFSEALLK VLQSALAAIR WFEENASQSTVK 2.53% SSPSSLSLAWAVPR VDTVAAEHLTR 67.60% AGKPVICATQMLESMIK APIIAVTR ASDVHEVR CCSGAIIVLTK CDENILWLDYK DIQDLK DPVQEAWAEDVDLR FDEILEASDGIMVAR FGVEQDVDMVFASFIR GADFLVTEVENGGSLGSK GADFLVTEVENGGSLGSKK GDLGIEIPAEK GDYPLEAVR GIFPVLCKDPVQEAWAEDVDLR
GSGTAEVELK GSGTAEVELKK GVNLPGAAVDLPAVSEK GVNLPGAAVDLPAVSEKDIQDLK
IENHEGVR ITLDNAYMEK IYVDDGLISLQVK KGVNLPGAAVDLPAVSEK LAPITSDPTEATAVGAVEASFK LDIDSPPITAR LNFSHGTHEYHAETIK MQHLIAR NTGIICTIGPASR QKGADFLVTEVENGGSLGSK RFDEILEASDGIMVAR RLAPITSDPTEATAVGAVEASFK
SAHQVAR SGMNVAR SVETLKEMIK TATESFASDPILYRPVAVALDTK TATESFASDPILYRPVAVALDTKGPEIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0%
54.7 51.3 47.0 46.5 56.7 36.6 72.0 36.2 90.0 130.0 37.5 60.0 68.8 72.7 39.7 47.2 48.7 59.2 60.2 52.2 57.7 42.7 103.0 41.4 120.0 124.0 54.9 67.3 50.4 50.7 60.2 65.3 96.0 81.9 54.0 68.6 109.0 84.7 159.0 69.5 35.6 41.5 75.5 86.0 96.0 26.5 33.1 70.1 42.2 63.6 58.4
22.3 18.1 22.1 22.6 21.8 21.9 23.3 11.5 14.1 20.6 21.8 21.6 18.1 21.8 21.8 21.5 22.4 14.3 21.1 22.8 22.0 24.4 21.9 21.9 22.4 21.8 22.2 21.5 22.7 20.5 23.3 22.3 20.1 17.8 22.5 22.6 19.4 17.8 21.2 21.5 22.2 20.8 23.2 22.2 22.5 20.5 20.0 23.8 21.2 19.1 17.9
3 4 2 1 2 1 8 3 9 4 2 2 2 2 1 1 1 18 10 2 5 2 15 1 24 66 2 32 22 0 8 28 15 6 15 40 87 6 87 60 0 8 10 2 35 0 2 4 7 10 0
0 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 7 0 0 0 0 0 0 0 16 0 2 0 0 3 0 4 0 14 0 0 0 8 45 0 1 0 0 4 84 1 0 0 1 77 5
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,243.69 1,169.69 1,217.67 1,100.57 1,358.73 1,272.70 1,421.71 1,236.77 1,409.84 2,099.10 1,144.65 1,731.92 1,041.64 1,425.67 1,457.78 1,211.64 1,908.96 840.53 912.45 1,221.63 1,468.68 731.39 1,642.77 1,665.82 1,875.90 1,779.88 1,907.97 1,141.61 1,019.52 2,557.28 990.51 1,118.61 1,636.89 2,349.27 953.48 1,197.58 1,462.82 1,764.99 2,175.12 1,197.65 1,883.90 884.48 1,359.71 2,036.03 1,821.92 2,331.22 768.41 734.36 1,193.65 2,465.29 3,017.60
Table S1 page 51/159
VFLAQK VNFAMNVGK VVEVGSK AFFMLDGILSK EDPIVYEIHPTK ETLDAQTFHTR ETSIFSYR ETSIFSYREDPIVYEIHPTK EVFNILQAAYVSKPGAQLAR FMQVVVSR GDLTIANLGTSEGR GNDIDPEAVKGEVLK IDLANR KEVFNILQAAYVSKPGAQLAR MVINVHEAGR NLNSVSVPR QAISSTVLGK SFISGGSTITGVGK SVSNSILECYTPAQTISTEFAVK TEFTTALQR VFPNSAPLEGGTR YVNDFFNK MGNTPDSASDNLGFR QPAGPGSGIR APLQGTLLGYR LAYQGQDTPEVLMDIGLR TATITVLPQQPR AVDNQVYVATASPAR ECSIYLIGGSIPEEDAGK LALIQLQISSIK LDSVLLLSSMNLPGGELR LGQGVLVQVSPSLVK ITHSPQAHDNPQEK LAADDPEVR FNVWDTAGQEK LVLVGDGGTGK NLQYYDISAK SNYNFEKPFLWLAR VCENIPIVLCGNK YVATLGVEVHPLVFHTNR DLFLQGAYDTVR DVTADFEGQSPK
Hepatocyte growth factor receptor
MET_HUMAN MET
155,525
100.00%
19
20
90
14.50%
Sulfatase-modifying factor 2
SUMF2_HUMAN SUMF2
33,825
100.00%
2
2
3
8.31%
Tyrosine-protein kinase receptor UFO
UFO_HUMAN AXL
98,317
100.00%
3
4
59
4.59%
Omega-amidase NIT2
NIT2_HUMAN NIT2
30,591
100.00%
3
3
6
16.30%
Exosome complex exonuclease RRP4 Ephrin-A1
EXOS2_HUMAN EXOSC2
32,771
99.90%
2
2
2
11.30%
EFNA1_HUMAN EFNA1
23,769
99.90%
2
2
13
11.20%
GTP-binding nuclear protein Ran
RAN_HUMAN RAN
24,405
100.00%
6
6
27
35.60%
Dipeptidyl peptidase 2
DPP2_HUMAN DPP7
54,325
99.50%
2
2
6
4.88%
40,497
100.00%
6
6
13
27,384
100.00%
4
4
12
21.80% DGMEYPFIGEGEPHVDGEPGDLR FQDLGAAYEVLSDSEK FQDLGAAYEVLSDSEKR LALQLHPDRNPDDPQAQEK TLEVEIEPGVR TTQLGPGR 23.00% AFYAELYHIISSNLEK IEDGNDFGVAIQEK QNLFQEAEEFLYR
DnaJ homolog subfamily B member DJB11_HUMAN DNAJB11 11
Proteasome activator complex subunit 2
PSME2_HUMAN PSME2
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
35.6 61.9 32.8 78.7 69.7 68.7 44.2 55.3 83.9 57.0 106.0 74.4 39.5 31.4 40.6 65.2 50.1 107.0 45.9 56.9 39.5 42.0 56.5 41.1 90.9 102.0 50.3 92.6 66.7 33.5 33.4 50.2 26.1 54.3 79.9 58.2 33.7 35.9 73.2 22.0 48.5 61.6 26.6 128.0 32.0 34.8 51.0 34.4 56.2 110.0 76.2
19.8 22.0 25.5 21.1 22.7 22.2 20.5 20.9 18.2 22.6 22.6 21.3 22.7 14.1 22.6 20.6 19.4 21.3 21.6 22.3 22.3 22.0 19.2 21.8 21.2 22.9 16.8 22.1 21.7 10.8 20.6 13.4 22.3 20.5 21.6 21.5 22.4 21.3 22.5 19.8 22.1 21.4 17.2 21.8 22.0 22.1 20.9 21.6 21.9 22.7 21.6
2 27 1 12 2 2 2 0 1 8 14 6 2 0 2 6 1 4 2 7 2 3 1 2 26 21 11 4 1 1 1 1 0 10 13 6 3 1 2 0 3 3 0 4 0 0 2 3 2 3 4
0 0 0 0 0 0 0 4 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
705.43 995.50 717.41 1,241.66 1,440.74 1,318.64 1,002.49 2,424.21 2,175.19 965.52 1,403.71 1,583.83 701.39 2,303.29 1,141.58 985.54 1,003.58 1,310.70 2,545.25 1,066.55 1,344.69 1,046.49 1,581.70 939.50 1,188.67 2,035.02 1,324.76 1,561.80 1,937.92 1,326.84 1,930.03 1,523.92 1,601.77 985.50 1,294.61 1,015.58 1,214.61 1,784.91 1,515.77 2,052.10 1,397.71 1,293.60 2,532.10 1,771.84 1,927.94 2,185.10 1,241.67 829.45 1,897.97 1,534.74 1,686.81
Table S1 page 52/159
Perilipin-3
PLIN3_HUMAN PLIN3
47,028
100.00%
3
3
8
Phospholipid transfer protein
PLTP_HUMAN PLTP
54,723
100.00%
9
11
112
Argininosuccinate lyase
ARLY_HUMAN ASL
51,641
99.50%
2
2
3
Complement factor H
CFAH_HUMAN CFH
139,078
100.00%
35
40
244
TKVEAFQTTISK 10.40% IATSLDGFDVASVQQQR TLTAAAVSGAQPILSK VSGAQEMVSSAK 24.70% AGALQLLLVGDK ATYFGSIVLLSPAVIDSPLK AVEPQLQEEER DPVASTSNLDMDFR FLEQELETITIPDLR TGLELSRDPAGR TMLQIGVMPMLNER VPHDLDMLLR VYDFLSTFITSGMR 7.33% INVLPLGSGAIAGNPLGVDR LNSNDEDIHTANER 34.20% AGEQVTYTCATYYK AQTTVTCMENGWSPTPR CFEGFGIDGPAIAK CNMGYEYSER CTSTGWIPAPR DGWSAQPTCIK DTSCVNPPTVQNAYIVSR ECDTDGWTNDIPICEVVK ECELPK EFDHNSNIR EIMENYNIALR EQVQSCGPPPELLNGNVK FVCNSGYK GEWVALNPLR HGGLYHENMR IDVHLVPDR IDVHLVPDRK IVSSAMEPDR IVSSAMEPDREYHFGQAVR KGEWVALNPLR LGYVTADGETSGSITCGK LSYTCEGGFR NTEILTGSWSDQTYPEGTQAIYK
RPYFPVAVGK SCDIPVFMNAR SIDVACHPGYALPK SLGNVIMVCR SPDVINGSPISQK SPPEISHGVVAHMSDSYQYGEEVTYK
UPF0556 protein C19orf10
CS010_HUMAN C19orf10
18,777
100.00%
2
3
5
SSNLIILEEHLK SSQESYAHGTK TDCLSLPSFENAIPMGEK TGDEITYQCR TGESVEFVCK WQSIPLCVEK 13.90% ESDVPLKTEEFEVTK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
76.5 89.0 42.1 56.8 86.8 63.0 64.2 71.0 64.4 38.3 85.6 36.2 77.6 101.0 36.0 54.7 38.6 83.5 58.2 51.9 34.1 82.4 60.8 30.4 57.0 85.2 74.1 34.0 70.8 37.1 34.5 26.5 60.5 42.7 42.6 43.7 65.3 70.8 42.8 56.1 65.7 59.5 71.8 41.4 64.5 41.0 71.3 49.7 35.8 42.7 71.1
19.5 22.1 18.3 22.6 16.6 14.1 22.7 18.3 21.5 21.7 23.2 22.4 22.7 16.8 19.6 20.8 20.0 22.3 7.8 22.1 21.0 22.3 17.6 20.5 20.3 22.7 22.2 18.6 20.4 19.4 20.8 18.7 22.9 21.8 18.5 20.8 19.5 21.0 20.5 21.3 22.6 22.6 22.5 19.0 18.9 19.7 21.5 18.3 21.4 22.8 22.7
3 3 2 3 16 6 31 3 9 1 11 0 22 2 0 5 1 9 4 2 1 4 1 1 7 20 4 2 7 0 5 0 9 0 6 1 3 5 3 8 4 12 18 0 16 1 8 9 1 6 2
0 0 0 0 0 0 0 0 2 4 0 7 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 4 0 0 0 4 28 0 0 0 0 2 17 0 0 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,352.74 1,834.93 1,527.87 1,209.58 1,197.72 2,091.17 1,327.65 1,583.70 1,816.97 1,271.67 1,632.83 1,208.65 1,636.80 1,933.09 1,627.73 1,654.74 1,951.86 1,481.71 1,324.49 1,245.61 1,262.58 2,020.98 2,150.94 775.37 1,131.52 1,365.68 1,965.97 974.44 1,154.63 1,229.55 1,063.59 1,191.69 1,120.53 2,192.06 1,282.73 1,815.84 1,189.53 2,602.23 1,133.65 1,309.60 1,527.76 1,164.59 1,341.70 2,926.32 1,395.78 1,194.54 2,008.94 1,242.54 1,155.54 1,259.65 1,750.88
Table S1 page 53/159
Platelet-derived growth factor subunit A Annexin A7
PDGFA_HUMAN PDGFA
24,025
99.50%
2
2
3
ANXA7_HUMAN ANXA7
52,723
99.50%
2
2
11
LIM domain and actin-binding protein 1
LIMA1_HUMAN LIMA1
85,208
100.00%
3
3
5
Nuclear transport factor 2
NTF2_HUMAN NUTF2
14,461
100.00%
3
3
7
Tropomyosin beta chain
TPM2_HUMAN TPM2
32,834
100.00%
13
16
65
Phosphoglucomutase-2
PGM2_HUMAN PGM2
68,268
100.00%
5
5
8
26,680
100.00%
7
7
24
27,747
100.00%
11
11
63
EF-hand domain-containing protein EFHD2_HUMAN EFHD2 D2
14-3-3 protein theta
1433T_HUMAN YWHAQ
SYLYFTQFK 13.30% SQVDPTSANFLIWPPCVEVK TVIYEIPR 5.12% GFGTDEQAIVDVVANR SEIDLVQIK 6.46% IAWPPPTELGSSGSALEEGIK ISANENSLAVR NENEEILERPAQLANAR 29.90% ADEDPIMGFHQMFLLK LSSLPFQK NINDAWVCTNDMFR 32.00% AEFAER GTEDEVEK IQLVEEELDR IQLVEEELDRAQER KATDAEADVASLNR KYEEVAR LDKENAIDR LEEAEKAADESER LKEAETR LKGTEDEVEK LVILEGELER RIQLVEEELDR YEEVAR 8.01% AAMGPGISR DLTTGYDDSQPDKK LDQETAQWLR MEFGTAGLR QLIDQGK 24.60% ADLNQGIGEPQSPSR ADLNQGIGEPQSPSRR DGFIDLMELK LGAPQTHLGLK LSEIDVSSEGVK RADLNQGIGEPQSPSR VQAINVSSR 59.20% AVTEQGAELSNEER DSTLIMQLLR EMQPTHPIR KEMQPTHPIR LAEQAER NLLSVAYK QTIDNSQGAYQEAFDISK QTIDNSQGAYQEAFDISKK SICTTVLELLDK TAFDEAIAELDTLNEDSYK TELIQK VISSIEQK YDDMATCMK YLAEVACGDDR YLAEVACGDDRK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
46.7 42.0 36.3 89.0 52.5 41.7 60.9 32.4 49.2 31.0 85.7 30.5 33.2 69.4 50.9 110.0 30.6 32.3 77.8 42.4 30.2 41.3 32.9 38.1 43.8 64.8 45.9 50.9 31.8 68.1 35.8 44.8 30.7 82.5 44.5 50.9 104.0 79.3 67.1 43.9 59.4 51.4 119.0 69.4 74.9 107.0 36.0 65.9 32.0 35.0 56.2
22.6 21.8 20.2 22.6 19.8 21.7 22.6 22.0 22.9 20.6 19.3 22.0 21.2 22.3 21.9 22.6 22.4 23.4 21.9 24.5 23.5 20.3 21.9 22.0 23.7 20.5 22.2 21.8 21.7 22.3 23.1 23.4 18.1 23.2 23.1 22.5 21.8 21.3 22.4 22.5 21.6 19.1 21.2 22.0 21.6 21.6 23.5 22.9 10.4 18.5 21.5
2 1 2 2 9 2 2 0 4 1 2 1 1 10 7 2 1 0 11 6 0 2 2 3 2 2 2 1 1 4 0 6 0 7 3 1 8 113 13 0 36 49 4 0 6 4 4 27 1 1 2
0 0 0 0 0 0 0 1 0 0 0 0 0 0 6 0 0 2 7 0 2 0 2 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 11 0 0 0 4 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,196.60 2,287.14 990.56 1,690.84 1,044.59 2,139.10 1,173.62 1,966.99 1,891.91 919.53 1,755.76 722.35 906.41 1,243.65 1,727.89 1,460.73 894.47 1,073.56 1,476.68 846.47 1,147.58 1,170.67 1,399.75 766.37 875.44 1,582.72 1,259.64 981.48 801.45 1,568.77 1,724.87 1,180.59 1,134.66 1,262.65 1,724.87 973.54 1,532.72 1,189.66 1,108.56 1,252.65 816.42 907.53 2,014.94 2,143.03 1,391.75 2,144.99 731.43 903.52 1,134.43 1,268.56 1,396.65
Table S1 page 54/159
Protein mago nashi homolog 2
MGN2_HUMAN MAGOHB
17,259
100.00%
5
5
8
Ubiquitin-conjugating enzyme E2 variant 1 Platelet-activating factor acetylhydrolase IB subunit alpha
UB2V1_HUMAN UBE2V1
16,477
100.00%
2
2
4
LIS1_HUMAN PAFAH1B1
46,619
100.00%
8
10
15
Aldehyde dehydrogenase, dimeric NADP-preferring
AL3A1_HUMAN ALDH3A1
50,362
100.00%
17
21
200
Trifunctional purine biosynthetic protein adenosine-3
PUR2_HUMAN GART
107,750
100.00%
3
3
5
3-ketoacyl-CoA thiolase, peroxisomal
THIK_HUMAN ACAA1
44,274
100.00%
4
4
6
Spermidine synthase
SPEE_HUMAN SRM
33,807
99.50%
2
2
3
Laminin subunit alpha-3
LAMA3_HUMAN LAMA3
366,625
100.00%
43
52
416
YLIANATNPESK 35.80% IGSLIDVNQSK IGSLIDVNQSKDPEGLR IIDDSEITKEDDALWPPPDR NDVMIR VFYYLVQDLK 13.60% LLEELEEGQK WTGMIIGPPR 22.20% EEFTSGGPLGQK GHTDSVQDISFDHSGK LNEAKEEFTSGGPLGQK SGKPGPFLLSGSR SNGYEEAYSVFK TAPYVVTGSVDQTVK VWDYETGDFER YALSGHR 41.90% DLYPVINGGVPETTELLK EKPLALYMFSSNDK ERFDHILYTGSTGVGK FDHILYTGSTGVGK HLTPVTLELGGK IIMTAAAK IQQLEALQR ISEAVKR LIQEQEQELVGALAADLHK LPEWAADEPVEK SCLVRPLMNDEGLK SFETFSHR SLEEAIQFINQR SLKEFYGEDAK VAYGGTGDAATR VMGLIEGQK VRYPPSPAK 3.86% ENLISALEEAKK FGDPECQVILPLLK VDLGGFAGLFDLK 12.00% AEELGLPILGVLR GNPGNITSR IAQFLSDIPETVPLSTVNR QVITLLNELK 7.62% AAFVLPEFAR VLIIGGGDGGVLR 15.50% AASASESALQTVIK AASASESALQTVIKEDLPR AGYTGTQCER ALGAIQR ALTDADNSVNK ANDITDEVLDGLNPIQTDVER APVYLGSPPSGKPK AQTLNNNVNR CAPGYFGNPQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
74.4 62.3 42.7 57.1 36.7 51.5 46.1 43.4 37.0 70.9 51.3 31.4 41.4 75.7 76.9 33.8 67.8 48.8 26.6 66.7 56.7 40.0 68.4 34.5 104.0 68.1 53.0 36.8 82.0 49.3 95.2 48.5 31.3 52.6 55.8 72.9 76.8 36.0 79.4 48.2 35.9 45.7 84.6 94.9 74.0 40.0 76.9 98.2 56.3 52.6 40.3
23.2 23.3 20.5 22.1 24.1 22.7 22.8 20.6 22.5 20.5 22.5 22.0 20.5 22.1 17.6 22.6 20.0 22.3 22.4 22.9 18.9 22.9 18.6 22.5 19.5 22.3 23.3 21.8 22.7 22.0 22.4 22.7 22.3 21.6 21.4 21.2 14.3 20.6 19.7 17.8 21.6 17.8 22.1 21.0 18.1 20.9 22.8 21.6 20.0 21.7 20.5
2 2 0 1 2 2 2 2 1 1 1 0 2 2 2 1 3 5 0 6 2 2 16 3 4 11 2 5 15 2 51 8 1 1 2 2 2 1 2 1 2 1 8 12 3 2 30 2 9 3 2
0 0 1 0 0 0 0 0 0 2 2 1 0 0 0 0 0 1 1 0 4 0 0 0 52 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 0 1 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,320.68 1,173.65 1,840.98 2,325.13 763.38 1,287.70 1,187.62 1,127.60 1,249.61 1,729.78 1,804.91 1,302.72 1,393.63 1,564.82 1,416.61 803.42 1,958.05 1,642.82 1,779.90 1,494.76 1,264.73 834.48 1,098.63 802.48 2,105.12 1,383.68 1,647.82 1,010.47 1,447.75 1,286.63 1,138.55 974.53 1,014.57 1,344.74 1,628.87 1,351.73 1,379.83 915.46 2,100.13 1,170.71 1,120.62 1,225.73 1,375.74 1,986.05 1,142.49 728.44 1,147.56 2,327.14 1,397.78 1,143.59 1,238.56
Table S1 page 55/159
CAVDAATAYENILNAIK EAELQVDQILTK EINSLQSDFTK ELTDLNQEFETLQEK ESQLLLNR FANSPRPDLWVLER FISLNIEDGK GATSSKPETPGVYDMDGR GDIDAMISSAK GLLFFAENGDR IKDTYGR INQLLQDTPVASPR KANDITDEVLDGLNPIQTDVER KAQTLNNNVNR LAASLNEAR LGGSNFEGCISNVFVQR LKQEVSPALNNLQQTLNIVTVQK
LLIDDQLLR LPDLWR LPQELLKPR LQEAAAQAK LSLSPEVLDLTSNSLK LSLSPEVLDLTSNSLKR NSFMALYLSK QANGLNQENER QEVSPALNNLQQTLNIVTVQK QISGTDGEGNNVPSGDFSR SAISNHGSK SPQTYMDGLLHYVSVISDNSGLR
Sulfhydryl oxidase 1
QSOX1_HUMAN QSOX1
82,561
100.00%
21
24
234
SQFAVDMQTTSSR SQLQGLSASAGLLEQMR TLSSNSDKLLNEAK VPTQPHAPIPTFGQTIQTTVDR VTASMDSGAGGTSTSVTPK YKLNSELPK 32.80% AAPGQEPPEHMAELQR AHFSPSNIILDFPAAGSAAR DCASHFEQMAAASMHR DFNIPGFPTVR DVQNVAAAPELAMGALELESR EVALDLSQHK FPVLEGQR IEVGRFPVLEGQR IYMADLESALHYILR KEGAVLAK LAGAPSEDPQFPK LEEIDGFFAR NGSGAVFPVAGADVQTLR NKIPYSFFK NNEEYLALIFEK RVLNTEANVVR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
102.0 87.7 58.5 119.0 51.8 30.8 47.6 67.8 65.7 51.7 30.5 102.0 100.0 63.0 66.7 92.0 50.1 68.7 33.0 39.7 65.2 110.0 78.1 35.5 60.6 121.0 98.8 44.2 44.8 74.7 108.0 59.5 79.3 97.0 29.8 70.3 97.2 27.1 44.5 98.4 55.9 42.2 46.9 36.6 31.4 71.9 51.0 84.9 28.7 92.0 45.6
22.9 22.6 22.1 22.6 23.0 21.2 23.1 20.5 23.5 22.5 21.5 20.6 20.4 21.1 23.4 22.2 11.1 20.3 20.7 12.6 21.6 20.9 17.2 22.7 20.7 16.6 20.4 20.5 21.5 19.9 22.6 22.0 19.9 21.4 20.8 22.1 21.6 13.0 22.8 22.2 22.1 22.9 19.9 22.2 21.0 22.0 22.8 22.4 22.9 22.3 20.1
2 7 15 29 7 0 4 5 10 6 1 8 2 2 12 2 0 33 1 1 4 15 8 1 2 7 12 4 0 7 11 1 0 12 0 6 11 0 11 3 9 11 2 1 1 20 8 8 0 10 6
0 0 0 0 0 4 0 9 0 0 0 0 17 3 0 0 11 0 0 0 0 1 2 0 0 2 0 0 2 0 2 0 37 0 1 0 27 1 0 0 0 0 2 0 0 0 0 0 2 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,836.92 1,386.75 1,281.63 1,836.89 972.55 1,699.89 1,135.60 1,867.85 1,107.54 1,238.62 852.46 1,551.85 2,455.23 1,271.68 944.52 1,883.91 2,578.46 1,098.65 799.45 1,093.67 929.51 1,715.94 1,872.04 1,189.59 1,272.59 2,337.28 1,936.86 900.45 2,568.24 1,473.66 1,804.92 1,519.80 2,404.26 1,769.82 1,091.61 1,776.83 2,042.05 1,864.75 1,262.65 2,184.10 1,139.61 945.52 1,499.83 1,823.94 815.50 1,356.68 1,196.60 1,758.91 1,143.62 1,482.75 1,270.72
Table S1 page 56/159
AN32E_HUMAN ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E
Nuclease-sensitive element-binding protein 1
YBOX1_HUMAN YBX1
30,675
100.00%
3
3
4
35,906
100.00%
9
10
63
SALYSPSDPLTLLQADTVR SFYTAYLQR TALDDRK VLNTEANVVR VPVLMESR 7.46% DLSTVEALQNLK IKDLSTVEALQNLK INLELR 47.20% AADPPAENSSAPEAEQGGAE EDGNEEDKENQGDETQGQQPPQR
GAEAANVTGPGGVPVQGSK NDTKEDVFVHQTAIK NEGSESAPEGQAQQR NYQQNYQNSESGEK NYQQNYQNSESGEKNEGSESAPEGQAQQR RPQYSNPPVQGEVMEGADNQGAGEQGRPVR
49,015
100.00%
3
3
8
ODO2_HUMAN DLST Dihydrolipoyllysine-residue succinyltransferase component of 2oxoglutarate dehydrogenase SF3A3_HUMAN SF3A3 Splicing factor 3A subunit 3
48,711
100.00%
3
3
9
58,833
100.00%
4
4
7
PCNA_HUMAN PCNA
28,751
100.00%
12
14
53
Eukaryotic peptide chain release factor subunit 1
Proliferating cell nuclear antigen
ERF1_HUMAN ETF1
SVGDGETVEFDVVEGEK 7.78% GFGGIGGILR LSVLGAITSVQQR YFDEISQDTGK 9.93% AKPAEAPAAAAPK ASAFALQEQPVVNAVIDDTTK VEGGTPLFTLR 12.80% EELNAISGPNEFAEFYNR ENPSEEAQNLVEFTDEEGYGR SLESLDTSLFAK VKPLQDQNELFGK 49.00% AEDNADTLALVFEAPNQEK ATPLSSTVTLSMSADVPLVVEYK
Actin-related protein 2/3 complex subunit 4
ARPC4_HUMAN ARPC4
19,649
100.00%
3
3
9
Actin-related protein 3
ARP3_HUMAN ACTR3
47,354
100.00%
8
9
23
DLSHIGDAVVISCAK FSASGELGNGNIK LVQGSILK LVQGSILKK MPSGEFAR NLAMGVNLTSMSK SEGFDTYR VSDYEMK YLNFFTK YYLAPK 17.90% AENFFILR ELLLQPVTISR VLIEGSINSVR 30.90% AEPEDHYFLLTEPPLNTPENR DITYFIQQLLR DREVGIPPEQSLETAK LGYAGNTEPQFIIPSCIAIK LSEELSGGR NIVLSGGSTMFR TLTGTVIDSGDGVTHVIPVAEGYVIGSCIK
Adenylyl cyclase-associated protein CAP1_HUMAN CAP1
51,838
100.00%
8
10
45
YSYVCPDLVK 23.40% AGAAPYVQAFDSLLAGPVAEYLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
121.0 51.0 36.0 51.0 50.2 47.3 49.1 39.6 36.1 43.3 115.0 35.6 70.5 37.8 85.1 61.5 45.0 40.9 65.0 62.0 39.8 108.0 52.8 73.8 119.0 65.8 46.2 90.9 50.8 65.1 98.0 32.1 43.5 43.7 83.3 47.9 49.0 37.8 31.5 49.8 66.4 58.2 28.8 46.9 81.2 76.7 59.3 66.4 33.3 38.8 77.6
21.4 23.3 24.3 22.9 23.1 22.7 17.9 21.8 17.7 15.8 22.3 22.7 19.2 17.7 15.6 20.6 21.7 20.1 17.8 18.5 21.6 20.9 21.6 20.6 17.8 22.1 21.5 21.7 20.4 22.5 23.2 19.2 11.5 20.6 23.3 15.7 17.1 23.6 19.6 21.7 17.1 21.2 21.8 19.1 21.9 21.3 23.5 22.3 19.2 20.2 20.0
64 10 4 12 3 1 1 2 2 0 25 0 6 1 0 0 2 2 3 3 0 2 2 1 2 2 2 19 2 2 3 2 2 7 7 2 2 1 2 5 2 2 0 2 4 2 5 5 0 2 2
2 0 0 0 0 0 0 0 0 18 0 2 0 0 5 1 0 0 0 0 5 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,047.07 1,148.57 818.44 1,114.62 946.50 1,330.72 1,571.90 757.46 1,897.81 2,628.11 1,695.87 1,744.89 1,587.70 1,688.72 3,257.40 3,239.53 1,795.82 946.55 1,371.80 1,302.59 1,192.67 2,217.14 1,189.66 2,099.97 2,413.04 1,310.68 1,515.82 2,074.99 2,424.26 1,584.81 1,293.64 857.55 985.64 910.41 1,365.69 974.42 871.39 932.49 754.41 1,009.55 1,268.76 1,186.68 2,482.19 1,409.78 1,768.91 2,192.14 947.48 1,297.66 3,058.58 1,243.60 2,351.23
Table S1 page 57/159
1
OSMR_HUMAN OSMR Oncostatin-M-specific receptor subunit beta SUMO-activating enzyme subunit 1 SAE1_HUMAN SAE1
110,492
99.90%
2
2
2
2.55%
38,432
100.00%
3
3
6
9.83%
EIGGDVQK EMNDAAMFYTNR LSDLLAPISEQIK NSLDCEIVSAK SGPKPFSAPKPQTSPSPK VENQENVSNLVIEDTELK VPTISINK LPLTPVSLK QPSQSYTLFESFSGEK AQNLNPMVDVK LDSSETTMVK VSQGVEDGPDTKR EDARPVPQGSCQSELHR LPGGLEPK QCHPALDGQR TGVKLPGGLEPK THEDLYIIPIPNCDR AAEDDEDDDVDTK AAEDDEDDDVDTKK EVVEEAENGR AFAVGVQQVLLK AIFQTIQNR ENIVEAIIHSPELIR ETENDDLTNVIQK EYNEFAEVFLK GIDQCIPLFVEAALER GTMDPALR QLQDIATLADQR QLQDIATLADQRR SDQNLQTALELTR ELPQFATGENLPR GTLGGLFSQILQGEDIVR DCLLELIEQK FGGSFLNCVR ILNETGK LPQVLAHLGALK QEVEIR SDTDVSMPLVEER SYENQKPPFDAK
Insulin-like growth factor-binding protein 4
IBP4_HUMAN IGFBP4
27,916
100.00%
5
5
25
20.90%
Prothymosin alpha
PTMA_HUMAN PTMA
12,185
100.00%
3
3
8
21.60%
Importin-7
IPO7_HUMAN IPO7
119,502
100.00%
10
10
17
10.60%
Apoptosis inhibitor 5
API5_HUMAN API5
57,545
99.50%
2
2
8
6.08%
UPF0553 protein C9orf64
CI064_HUMAN C9orf64
39,012
100.00%
5
6
9
17.00%
NADPH--cytochrome P450 reductase Lactoylglutathione lyase
NCPR_HUMAN POR
76,673
99.50%
2
2
3
5.17%
LGUL_HUMAN GLO1
20,761
100.00%
4
4
26
PCNP_HUMAN PCNP
18,907
100.00%
4
5
10
Rab GDP dissociation inhibitor alpha GDIA_HUMAN GDI1
50,566
100.00%
10
10
30
25.00% DFLLQQTMLR GLAFIQDPDGYWIEILNPNK IAWALSR VLGMTLIQK 29.80% AGAAGGPEEEAEKPVK FGFAIGSQTTK SAEEEAADLPTKPTK SHLGNVHDQDN 45.00% DWNVDLIPK FLMANGQLVK FQLLEGPPESMGR
PEST proteolytic signal-containing nuclear protein
YESGDHVAVYPANDSALVNQLGK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
35.0 76.7 70.9 35.6 50.7 116.0 33.9 34.6 41.4 44.9 39.1 41.4 55.8 35.2 40.0 49.0 76.3 67.4 89.5 63.3 70.8 49.3 42.8 66.5 36.1 38.2 43.7 53.7 28.3 77.4 60.8 53.1 47.6 42.4 37.1 58.2 37.8 48.4 43.1 27.8 77.6 112.0 45.1 59.2 76.2 61.0 71.6 39.0 43.3 43.4 78.3
22.0 14.5 18.0 22.5 20.5 22.4 20.4 6.0 22.9 23.7 20.9 22.2 21.1 16.2 21.0 15.7 21.8 10.0 16.6 20.8 14.3 22.2 20.1 22.3 21.0 22.3 23.1 22.7 21.9 22.9 22.4 19.9 23.6 21.3 24.6 10.4 23.5 20.9 21.9 21.6 22.4 20.5 22.3 18.5 21.9 22.2 22.4 18.2 21.6 22.8 23.0
3 5 15 2 0 10 3 1 1 2 2 2 0 1 0 0 5 2 2 4 2 2 2 2 2 1 1 2 0 2 6 2 1 2 1 2 1 1 2 0 8 4 7 7 2 2 2 2 2 6 4
0 0 0 0 2 2 0 0 0 0 0 0 7 0 8 4 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 2 0 0 0 1 0 0 0 0 0 0 2 0 0 0 0
0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
845.44 1,494.60 1,426.82 1,235.59 1,837.98 2,073.04 871.53 967.62 1,834.85 1,244.63 1,126.53 1,387.68 1,965.92 810.47 1,181.55 1,195.71 1,855.90 1,437.55 1,565.65 1,131.53 1,272.77 1,090.60 1,732.96 1,518.73 1,388.67 1,830.94 876.43 1,371.72 1,527.82 1,488.77 1,471.75 1,903.03 1,260.65 1,156.56 774.44 1,259.78 773.42 1,493.68 1,423.69 2,447.18 1,280.67 2,303.17 816.47 1,002.60 1,539.77 1,156.60 1,586.79 1,235.54 1,099.58 1,136.61 1,460.72
Table S1 page 58/159
Calcium-binding protein 39
CAB39_HUMAN CAB39
39,853
100.00%
4
4
4
Arginyl-tRNA synthetase, cytoplasmic
SYRC_HUMAN RARS
75,364
100.00%
5
5
13
Fibulin-1
FBLN1_HUMAN FBLN1
77,194
100.00%
13
13
113
GRDWNVDLIPK IICILSHPIK IYKVPSTETEALASNLMGMFEK KQNDVFGEAEQ LYSESLAR MAGTAFDFENMKR MLLYTEVTR NPYYGGESSSITPLEELYK NTNDANSCQIIIPQNQVNR SPYLYPLYGLGELPQGFAR TDDYLDQPCLETVNR TFEGVDPQTTSMR VPSTETEALASNLMGMFEK VVEGSFVYK 12.90% FQNDRTEDEQFNDEK LIEFLSK LLGELLLDR LLSAEFLEQHYDR 10.60% AAYPDLENPPLLVTPSQQAK GFDILGIKPVQR SDGGYTYDTSDLAAIK STIIGESISR VIVDFSSPNIAK 21.50% AITPPHPASQANIIFDITEGNLR CLAFECPENYR DSFDIIKR EFTRPEEIIFLR GYHLNEEGTR IIEVEEEQEDPYLNDR LEMNYVVGGVVSHR MCVDVNECQR SAATLQQEK SQETGDLDVGGLQETDK SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDR
Leucine-rich PPR motif-containing protein, mitochondrial
LPPRC_HUMAN LRPPRC
157,894
100.00%
6
6
9
Inorganic pyrophosphatase
IPYR_HUMAN PPA1
32,643
100.00%
4
4
7
Translationally-controlled tumor protein
TCTP_HUMAN TPT1
19,578
100.00%
5
7
51
TGYYFDGISR YMDGMTVGVVR 5.09% LQDAINILK NVQGIIEILK SNTLPISLQSIR SYVSEKDVTSAK TVLDQQQTPSR TVQLTSSELESTLETLK 19.40% AAPFSLEYR DKDFAIDIIK VIAINVDDPDAANYNDINDVK VLGILAMIDEGETDWK 33.10% DGLEMEKC DLISHDEMFSDIYK EDGVTPYMIFFK GKLEEQRPER VKPFMTGAAEQIK
95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
36.0 26.5 32.2 43.0 55.9 36.4 53.4 108.0 59.4 98.6 79.5 79.6 104.0 30.8 26.2 31.9 57.2 27.4 79.9 35.2 81.8 31.7 67.7 59.1 53.0 40.1 44.5 39.8 98.8 28.3 53.3 64.8 137.0 71.0 76.1 73.4 32.8 31.1 40.3 44.3 55.6 46.0 35.7 51.6 110.0 50.7 34.8 88.5 65.4 39.9 56.1
21.5 16.9 21.6 20.9 20.3 18.3 23.0 22.1 21.9 21.6 20.2 21.4 21.2 20.9 16.5 14.1 19.1 22.6 20.5 18.6 21.2 22.2 21.1 19.7 16.6 21.6 20.4 19.5 21.1 23.0 15.2 23.1 22.4 19.4 21.7 21.0 17.8 17.2 20.7 22.1 22.7 20.2 22.0 21.7 22.2 22.1 12.3 21.5 22.4 21.1 21.2
1 0 0 4 6 2 13 2 1 8 2 4 8 1 0 1 1 0 4 0 2 2 4 0 3 5 5 12 6 0 10 3 8 0 18 5 1 1 1 1 4 1 2 2 2 1 1 17 10 2 9
0 1 2 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 28 0 0 0 0 0 2 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 5
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,312.70 1,193.71 2,491.21 1,264.58 938.49 1,549.68 1,125.60 2,147.02 2,199.06 2,141.11 1,838.82 1,468.67 2,070.97 1,027.55 1,914.81 849.51 1,041.63 1,620.80 2,152.13 1,342.79 1,676.77 1,062.58 1,289.71 2,475.30 1,458.61 993.54 1,549.84 1,175.54 1,990.92 1,575.80 1,326.52 975.51 1,791.83 3,763.73 1,178.55 1,227.59 1,027.62 1,126.68 1,328.75 1,313.66 1,272.66 1,878.99 1,053.54 1,177.65 2,288.10 1,805.90 997.40 1,712.78 1,446.70 1,241.66 1,419.77
Table S1 page 59/159
Ras-related protein Rab-1B
RAB1B_HUMAN RAB1B
22,154
99.50%
2
3
5
Actin, cytoplasmic 1
ACTB_HUMAN ACTB
41,720
100.00%
19
28
1414
34.80% EFADSLGIPFLETSAK LLLIGDSGVGK LQIWDTAGQER MGPGAASGGERPNLK NATNVEQAFMTMAAEIK 58.70% AGFAGDDAPR AVFPSIVGRPR CDVDIRK DLTDYLMK DLYANTVLSGGTTMYPGIADR DSYVGDEAQSK DSYVGDEAQSKR EITALAPSTMK GYSFTTTAER HQGVMVGMGQK IIAPPER IIAPPERK IWHHTFYNELR KDLYANTVLSGGTTMYPGIADR LCYVALDFEQEMATAASSSSLEK
QEYDESGPSIVHR SYELPDGQVITIGNER TTGIVMDSGDGVTHTVPIYEGYALPHAILR
ATP synthase subunit alpha, mitochondrial
ATPA_HUMAN ATP5A1
Serine/threonine-protein phosphatase 2AAA_HUMAN PPP2R1A 2A 65 kDa regulatory subunit A alpha isoform
59,734
100.00%
4
4
6
65,292
100.00%
10
13
31
Galectin-3
LEG3_HUMAN LGALS3
26,135
100.00%
6
10
65
Serine protease HTRA1
HTRA1_HUMAN HTRA1
51,269
100.00%
12
13
78
VAPEEHPVLLTEAPLNPK 9.22% AVDSLVPIGR TGAIVDVPVGEELLGR TGTAEMSSILEER VVDALGNAIDGK 25.00% AISHEHSPSDLEAHFVPLVK IGPILDNSTLQSEVKPILEK LAGGDWFTSR LTQDQDVDVK MAGDPVANVR NLCSDDTPMVR QLSQSLLPAIVELAEDAK SALASVIMGLSPILGK SEIIPMFSNLASDEQDSVR VLAMSGDPNYLHR 28.40% GNDVAFHFNPR IALDFQR IQVLVEPDHFK MLITILGTVKPNANR QSVFPFESGKPFK VAVNDAHLLQYNHR 27.70% ADIALIK ESTLNMVVR EVPVASGSGFIVSEDGLIVTNAHVVTNK
GACGQGQEDPNSLR IAPAVVHIELFR IDHQGKLPVLLLGR IKDVDEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
77.3 58.7 61.5 51.6 84.4 81.5 65.7 34.7 51.3 125.0 81.6 63.0 68.7 76.4 48.0 42.4 39.0 55.8 96.1 99.6 58.9 125.0 74.2 85.4 31.1 30.5 67.5 56.7 22.0 84.4 55.2 37.1 66.6 39.0 84.9 37.8 105.0 73.9 66.6 43.1 54.1 86.9 41.8 75.1 35.5 33.6 29.9 38.2 51.1 50.7 35.9
23.1 20.3 22.2 21.6 19.7 21.2 18.6 23.7 20.6 21.7 19.0 21.6 23.5 20.0 21.7 17.9 16.0 22.4 21.4 20.3 21.4 22.9 20.0 18.4 19.3 20.2 20.6 23.1 21.0 14.6 21.7 23.6 22.0 18.1 18.6 15.7 22.4 21.8 21.8 24.4 20.6 14.8 22.1 22.6 19.8 23.5 19.2 18.6 15.2 10.8 24.7
7 2 7 2 2 149 47 1 26 149 88 43 60 154 19 6 5 0 2 26 36 175 0 60 2 1 1 2 0 2 2 2 2 1 7 2 4 2 10 4 7 9 1 2 3 2 0 1 2 0 1
0 0 0 1 0 0 0 0 0 6 0 7 0 0 13 0 0 53 10 22 53 2 81 44 0 0 0 0 0 1 0 0 0 0 1 0 0 2 0 0 11 12 5 4 0 0 2 0 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,724.87 1,071.64 1,316.66 1,457.72 1,900.88 976.45 1,198.71 905.45 1,014.48 2,231.07 1,198.52 1,354.62 1,177.61 1,132.53 1,171.57 795.47 923.57 1,515.75 2,359.16 2,566.17 1,516.70 1,790.89 3,183.62 1,954.07 1,026.59 1,624.89 1,439.67 1,171.63 2,213.14 2,194.23 1,109.54 1,160.58 1,045.51 1,323.57 1,925.06 1,572.90 2,138.01 1,488.73 1,273.61 862.48 1,324.73 1,640.95 1,497.77 1,649.85 743.47 1,064.54 2,839.48 1,488.65 1,364.81 1,558.94 846.46
Table S1 page 60/159
Dermcidin
DCD_HUMAN DCD
11,266
99.50%
2
2
69
Vacuolar protein sorting-associated protein 35
VPS35_HUMAN VPS35
91,692
100.00%
11
11
30
LHRPPVIVLQR LPVLLLGR MMSLTSSK VTAGISFAIPSDK YNFIADVVEK 20.00% DAVEDLESVGK ENAGEDPGLAR 17.60% AELAELPLR ENDAVTIQVLNQLIQK GVQHPLR ILVGTNLVR IPVDTYNNILTVLK IREDLPNLESSEETEQINK LLDEAIQAVK LSQLEGVNVER PTTQQSPQDEQEKLLDEAIQAVK
SEDPDQQYLILNTAR VADLYELVQYAGNIIPR AMGPLVLTEVLFNEK VLTLSDDLER EFPGFLENQKDPLAVDK FAGDKGYLTK PSQMEHAMETMMFTFHK ATIGADFLTK DPENFPFVVLGNK EAINVEQAFQTIAR FQSLGVAFYR LVTMQIWDTAGQER NNIPYFETSAK TSLMNQYVNK ALDTMNFDVIK EFSPFGSITSAK FSPAGPVLSIR GFGFVCFSSPEEATK SLGYAYVNFQQPADAER
49,205
99.50%
2
2
4
5.80%
S10AA_HUMAN S100A10
11,186
100.00%
3
5
9
45.40%
Ras-related protein Rab-7a
RAB7A_HUMAN RAB7A
23,472
100.00%
7
8
27
39.60%
Polyadenylate-binding protein 4
PABP4_HUMAN PABPC4
70,766
99.50%
2
2
5
10.20%
Legumain
LGMN_HUMAN LGMN
49,393
100.00%
7
7
41
Coronin-1B
COR1B_HUMAN CORO1B
54,217
99.50%
2
2
5
ATP-dependent RNA helicase DDX1 Myosin-9
DDX1_HUMAN DDX1
82,415
100.00%
2
2
3
MYH9_HUMAN MYH9
226,520
100.00%
38
44
163
21.00% ASSPVPLPPVTHLDLTPSPDVPLTIMK DYTGEDVTPQNFLAVLR IVSLLAASEAEVEQLLSER KLMNTNDLEESR LMNTNDLEESR QLTEEIQR VMQFQGMK 4.29% DADPILISLR VGIIAWHPTAR 2.57% ELAEQTLNNIK TGASVLNK 24.50% AGVLAHLEEER ALEEAMEQK ALELDSNLYR ANLQIDQINTDLNLER DFSALESQLQDTQELLQEENR
Eukaryotic translation initiation factor 5 Protein S100-A10
IF5_HUMAN
EIF5
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
41.1 57.6 50.2 42.6 55.8 50.7 90.3 46.3 79.1 30.5 63.1 79.8 45.7 54.4 70.8 48.8 73.2 34.0 75.7 35.8 64.8 33.6 20.0 59.5 64.4 89.0 67.9 83.8 32.1 31.5 73.5 41.4 48.9 61.6 97.2 50.0 78.1 64.7 75.1 65.0 47.0 31.1 57.1 34.2 46.1 41.0 48.5 48.8 69.8 133.0 125.0
9.0 6.0 16.8 22.0 22.0 23.0 20.9 17.7 19.1 20.5 16.7 17.6 21.8 21.6 22.3 21.4 22.5 20.8 21.3 23.5 22.5 22.6 17.5 20.2 22.5 22.4 22.0 23.3 21.7 21.7 21.7 21.6 21.1 19.8 21.3 17.4 22.1 18.4 21.1 20.1 22.3 18.7 19.9 20.5 22.7 22.9 23.8 22.2 23.2 22.0 20.8
2 45 3 1 8 1 68 4 2 1 1 10 0 2 3 0 2 0 3 1 4 2 0 2 4 12 2 4 1 1 12 1 4 1 5 0 17 1 5 6 5 1 3 0 2 1 1 3 5 4 5
6 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 1 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 2 0 0 1 0 0 0 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,327.83 880.60 916.41 1,305.71 1,197.62 1,161.56 1,128.53 1,011.58 1,826.00 806.46 984.62 1,602.91 2,244.10 1,099.64 1,243.66 2,596.31 1,762.86 1,934.04 1,676.89 1,160.62 1,946.99 1,099.58 2,082.89 1,036.57 1,475.75 1,589.83 1,187.62 1,647.82 1,283.63 1,213.59 1,282.64 1,270.63 1,143.65 1,662.75 1,928.91 2,838.53 1,937.96 2,057.11 1,465.70 1,337.60 1,016.54 1,000.46 1,112.63 1,220.69 1,272.68 789.45 1,223.64 1,064.49 1,193.62 1,869.97 2,493.17
Table S1 page 61/159
Glypican-1
GPC1_HUMAN GPC1
61,663
100.00%
18
22
271
ELEDATETADAMNR ELESQISELQEDLESER EMEAELEDERK FVSELWK HSQAVEELAEQLEQTKR IAEFTTNLTEEEEK IAEFTTNLTEEEEKSK IAQLEEELEEEQGNTELINDR IAQLEEQLDNETK IAQLEEQLDNETKER IIGLDQVAGMSETALPGAFK IMGIPEEEQMGLLR IRELESQISELQEDLESER KEEELQAALAR KFDQLLAEEK KQELEEICHDLEAR LDPHLVLDQLR LQVELDNVTGLLSQSDSK MQQNIQELEEQLEEEESAR NFINNPLAQADWAAK NLPIYSEEIVEMYK NRDEAIK NTDQASMPDNTAAQK QAQQERDELADEIANSSGK QLEEAEEEAQR QLLQANPILEAFGNAK QQQLTAMK RGDLPFVVPR TEMEDLMSSKDDVGK THEAQIQEMR VEAQLQELQVK VISGVLQLGNIVFK VKLQEMEGTVK 37.30% DVQDFWISLPGTLCSEK ERPPSGTLEK GCLANQADLDAEWR GFSLSDVPQAEISGEHLR KVAQVPLGPECSR MALSTASDDR QAEALRPFGEAPR QQIMQLK SFVQGLGVASDVVR SFVQGLGVASDVVRK SHAELETALR TLQATFPGAFGELYTQNAR VAQVPLGPECSR VIQGCGNPK VLQAMLATQLR VNPQGPGPEEK VNPQGPGPEEKR YLPEVMGDGLANQINNPEVEVDITKPDMTIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
88.5 107.0 45.1 33.0 50.3 101.0 87.6 98.9 83.1 27.0 92.1 64.0 47.9 66.7 35.6 31.3 50.3 65.3 137.0 82.4 33.7 37.2 94.1 55.2 70.5 81.5 36.3 26.4 57.4 38.7 37.6 60.0 31.1 50.6 41.6 62.1 56.1 45.6 61.9 32.8 32.8 97.2 74.7 40.2 105.0 48.5 38.4 51.7 44.8 52.9 80.9
17.0 21.4 20.0 22.0 21.9 22.0 22.3 20.6 22.3 22.3 21.3 23.3 21.6 22.8 22.6 21.8 18.9 21.4 20.3 22.6 20.6 23.0 18.1 20.7 20.4 19.4 23.6 19.6 17.0 21.5 21.1 12.0 22.8 22.1 21.2 20.3 21.8 21.6 20.5 21.9 23.4 21.3 18.8 22.7 23.2 22.3 21.3 20.4 23.0 22.7 19.8
8 6 3 1 0 6 1 2 8 0 12 3 0 5 1 0 4 3 1 6 2 1 5 0 3 28 1 0 2 2 2 3 0 4 9 2 6 2 9 0 3 61 2 5 54 8 4 13 35 13 0
0 0 0 0 2 0 0 2 0 1 0 0 2 0 0 1 5 0 3 0 0 0 0 3 0 0 0 1 1 0 0 0 2 0 0 0 9 7 0 4 0 0 0 0 12 0 0 0 0 7 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,581.67 2,033.95 1,394.61 908.49 1,996.01 1,653.79 1,868.91 2,472.17 1,530.77 1,815.91 2,018.06 1,647.81 2,303.14 1,257.68 1,220.65 1,769.85 1,318.75 1,946.01 2,333.06 1,672.84 1,743.85 845.45 1,591.70 2,088.98 1,331.61 1,726.95 963.49 1,155.66 1,716.73 1,258.59 1,284.72 1,486.90 1,277.68 1,994.95 1,113.59 1,618.73 1,941.97 1,440.76 1,082.48 1,441.76 904.49 1,433.78 1,561.87 1,126.59 2,085.04 1,312.67 972.49 1,259.71 1,151.57 1,307.67 3,503.70
Table S1 page 62/159
Profilin-1
PROF1_HUMAN PFN1
15,036
100.00%
8
13
157
Chromobox protein homolog 5
CBX5_HUMAN CBX5
22,208
100.00%
2
2
4
Macrophage migration inhibitory factor Pyridoxal kinase
MIF_HUMAN
12,459
99.50%
2
2
8
PDXK_HUMAN PDXK
35,084
100.00%
5
5
9
Coproporphyrinogen-III oxidase, mitochondrial 5'(3')-deoxyribonucleotidase, cytosolic type
HEM6_HUMAN CPOX
50,134
100.00%
2
2
6
NT5C_HUMAN NT5C
23,365
100.00%
3
3
6
Beta-galactosidase
BGAL_HUMAN GLB1
76,060
100.00%
2
2
9
Metastasis-associated protein MTA2 MTA2_HUMAN MTA2
75,007
99.50%
2
2
2
Nucleosome assembly protein 1-like NP1L1_HUMAN NAP1L1 1 PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11
45,357
100.00%
2
2
10
47,448
100.00%
4
4
6
MIF
55.70% CYEMASHLR DSLLQDGEFSMDLR DSPSVWAAVPGK STGGAPTFNVTVTK TDKTLVLLMGK TFVNITPAEVGVLVGK TFVNITPAEVGVLVGKDR TLVLLMGK 14.70% SNFSNSADDIK TADSSSSEDEEEYVVEK 17.40% LLCGLLAER PMFIVNTNVPR 24.00% AQAGEGVRPSPMQLELR GQVLNSDELQELYEGLR NPAGSVVMER VVPLADIITPNQFEAELLSGR YDYVLTGYTR 6.61% ATSLGRPEEEEDELAHR IESILMSLPLTAR 19.90% LLSWSDNWR VLVDMDGVLADFEAGLLR WVEQHLGPQFVER 4.28% AYVAVDGIPQGVLER TEAVASSLYDILAR 7.04% LNPADAPNPVVFVATK VKPTLIAVRPPVPLPAPSHPASTNEPIVLED
Apolipoprotein A-I
APOA1_HUMAN APOA1
30,761
100.00%
3
3
7
Thioredoxin-like protein 1
TXNL1_HUMAN TXNL1
32,233
100.00%
4
5
7
Radixin
RADI_HUMAN RDX
68,548
100.00%
9
10
24
6.91% FYEEVHDLER LDGLVETPTGYIESLPR 12.30% EASIDILHSIVK IMLNTPEDVQALVSGK LYDNLLEQNLIR TGQAAELGGLLK 15.40% DYVSQFEGSALGK EQLGPVTQEFWDNLEK VSFLSALEEYTK 17.00% IFINLPR IKQHLENDPGSNEDTDIPK QHLENDPGSNEDTDIPK SEPTQALELTEDDIKEDGIVPLR 36.20% AFAAQEDLEK ALELDQER APDFVFYAPR EKEELMER ENPLQFK FVIKPIDK IAQDLEMYGVNYFEIK IGFPWSEIR ILALCMGNHELYMR KALELDQER KAPDFVFYAPR KENPLQFK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
44.5 105.0 61.2 78.5 65.1 102.0 86.8 56.4 42.9 130.0 66.2 72.6 26.8 103.0 46.3 56.6 61.9 32.6 78.5 37.5 111.0 32.8 38.4 80.9 63.7 30.7 48.4 80.5 34.7 65.0 83.4 68.5 41.7 78.3 85.9 44.0 48.1 48.8 38.7 40.5 34.1 80.6 33.2 35.5 41.1 55.0 68.8 40.7 31.0 47.6 31.1
18.5 21.4 21.4 23.1 17.6 17.7 17.2 17.6 20.9 14.3 22.2 23.9 21.4 22.5 21.7 17.7 22.2 21.8 19.6 22.5 21.7 21.6 22.1 21.6 20.0 13.6 21.0 21.1 18.8 22.2 20.8 22.4 21.1 22.7 21.5 20.3 22.0 19.6 21.0 23.6 21.5 21.7 21.6 24.5 17.2 23.2 23.4 21.7 23.2 22.3 21.9
3 78 4 8 10 22 2 14 2 2 4 4 0 3 2 1 2 0 4 2 2 0 2 7 1 0 4 6 1 1 2 2 1 4 2 2 0 1 0 3 1 84 2 1 6 2 121 2 1 25 1
2 2 0 0 7 2 3 0 0 0 0 0 1 0 0 0 0 2 0 0 0 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 2 0 0 0 0 0 0 0 0 0 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,182.50 1,625.75 1,213.62 1,379.72 1,218.71 1,643.94 1,915.07 874.54 1,197.54 1,903.79 1,044.59 1,303.68 1,838.95 1,962.98 1,059.53 2,282.24 1,250.61 1,938.92 1,459.82 1,176.58 1,949.01 1,624.82 1,586.85 1,508.80 1,652.90 3,254.82 1,336.62 1,859.98 1,324.75 1,730.90 1,503.82 1,157.65 1,400.67 1,932.93 1,386.72 872.54 2,150.04 1,908.86 2,568.31 1,121.55 973.50 1,182.59 1,079.50 875.46 959.59 1,948.94 1,104.58 1,752.82 1,101.59 1,310.69 1,003.56
Table S1 page 63/159
KPDTIEVQQMK KTQNDVLHAENVK LFFLQVK LKQIEEQTIK NISFNDKK NQEQLAAELAEFTAK QAADQMKNQEQLAAELAEFTAK
S-formylglutathione hydrolase
ESTD_HUMAN ESD
31,446
100.00%
8
8
28
QLFDQVVK QLQALSSELAQAR RKPDTIEVQQMK VLEQHK VTTMDAELEFAIQPNTTGK 38.30% AFSGYLGTDQSK AYDATHLVK FAVYLPPK KAFSGYLGTDQSK MYSYVTEELPQLINANFPVDPQR
SGYHQSASEHGLVVIAPDTSPR SVSAFAPICNPVLCPWGK SYPGSQLDILIDQGK ATVLNYLPK GPTQEFK LPPNVVEESAR QTVSWAVTPK AAPEASGTPSSDAVSR DAGPLLISLK KGTVVAEK IVLTNPVCTEVGEK VGQEIEVRPGIVSK FNEVAAQYSEDK
Alpha-2-macroglobulin
A2MG_HUMAN A2M
163,273
100.00%
4
4
12
2.51%
Coronin-1A
COR1A_HUMAN CORO1A
51,008
100.00%
3
3
7
7.38%
Eukaryotic translation initiation factor 2 subunit 3 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Renin receptor
IF2G_HUMAN EIF2S3
51,092
100.00%
2
3
5
5.93%
PIN4_HUMAN PIN4
13,792
99.50%
2
2
5
32.10%
RENR_HUMAN ATP6AP2
38,991
100.00%
2
2
4
D-dopachrome decarboxylase
DOPD_HUMAN DDT
12,694
100.00%
4
4
9
Syntaxin-binding protein 2
STXB2_HUMAN STXBP2
66,423
99.50%
2
2
2
V-set and transmembrane domaincontaining protein 2-like protein Platelet-activating factor acetylhydrolase IB subunit beta T-complex protein 1 subunit theta
VTM2L_HUMAN VSTM2L
22,331
99.50%
2
2
2
PA1B2_HUMAN PAFAH1B2
25,552
99.90%
2
3
28
TCPQ_HUMAN CCT8
59,603
100.00%
15
15
33
7.43% LFQENSVLSSLPLNSLSR SFDTSLIR 36.40% FFPLESWQIGK PFLELDTNLPANR PFLELDTNLPANRVPAGLEK SHSAHFFEFLTK 3.88% ILSGVIR LIVPVLLDAAVPAYDK 18.10% VQPGENSVLHLPEAPPAAPAPPPPKPGK VVGSNISHK 12.20% ELFSPLHALNFGIGGDTTR IIVLGLLPR 31.60% AIADTGANVVVTGGK ANEVISK APGFAQMLK AVDDGVNTFK DIDEVSSLLR DMLEAGILDTYLGK EDGAISTIVLR FAEAFEAIPR
GSMVGPFQEAAFALPVSGMDKPVFTDPPVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0%
64.0 27.7 42.2 28.2 31.2 109.0 26.4 58.8 101.0 51.6 34.7 106.0 70.0 48.9 51.0 64.6 46.7 31.5 61.5 76.5 46.2 31.5 40.0 43.8 82.2 48.2 30.1 32.8 45.8 85.7 44.4 92.5 32.9 61.0 81.2 38.8 39.8 33.9 30.0 42.4 35.6 74.1 55.9 83.2 52.5 39.6 30.2 54.0 70.1 40.1 78.6
23.1 22.8 18.9 20.0 22.7 23.0 21.8 21.4 22.0 22.3 19.1 22.4 21.8 23.3 21.4 22.7 21.8 21.8 22.7 22.3 18.4 23.7 22.4 23.0 20.3 16.0 21.9 22.8 18.3 18.6 20.7 19.4 20.3 21.8 22.1 18.1 22.8 21.8 14.6 16.5 20.0 22.1 4.8 22.1 25.0 23.4 22.3 23.8 22.6 23.0 21.2
5 0 11 0 2 8 0 19 3 12 2 27 8 4 6 2 0 0 2 2 2 2 1 7 4 2 1 1 2 2 0 3 1 3 2 0 0 1 1 0 1 2 24 2 2 2 1 2 4 2 4
0 1 0 2 0 2 1 0 0 33 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 0 0 2 0 3 0 0 0 0 2 2 0 0 1 0 2 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,316.69 1,495.79 894.55 1,229.71 965.51 1,662.83 2,451.18 976.55 1,414.77 1,488.78 753.43 2,082.01 1,273.61 1,017.54 934.54 1,401.70 2,740.33 2,308.13 2,002.99 1,633.84 1,018.59 806.41 1,210.64 1,116.61 1,502.71 1,026.62 831.49 1,558.82 1,510.86 1,400.63 3,151.55 2,004.08 938.49 1,351.71 1,499.79 2,194.19 1,450.71 757.49 1,696.99 2,792.51 940.52 2,045.05 993.68 1,372.74 760.42 962.51 1,065.52 1,146.60 1,538.78 1,173.65 1,150.59
Table S1 page 64/159
Erythrocyte band 7 integral membrane protein
STOM_HUMAN STOM
31,714
100.00%
10
11
58
46.50%
EH domain-containing protein 1
EHD1_HUMAN EHD1
60,611
100.00%
3
3
4
7.30%
Citrate synthase, mitochondrial
CISY_HUMAN CS
51,696
100.00%
9
9
23
20.00%
Tryptophanyl-tRNA synthetase, cytoplasmic
SYWC_HUMAN WARS
53,150
100.00%
8
11
45
27.40%
Leukocyte elastase inhibitor
ILEU_HUMAN SERPINB1
42,726
100.00%
14
16
62
38.30%
GSTDNLMDDIER LFVTNDAATILR LVPGGGATEIELAK QYGNEVFLAK TAEELMNFSKGEENLMDAQVK VADMALHYANK YNIMLVR AMAAEAEASR EASMVITESPAALQLR GPGLFFILPCTDSFIK LLAQTTLR LPVQLQR NSTIVFPLPIDMLQGIIGAK TISFDIPPQEILTK VIAAEGEMNASR VQNATLAVANITNADSATR YLQTLTTIAAEK ELVNNLGEIYQK LLDTVDDMLANDIAR QEESLMPSQVVK ALGFPLERPK AYAQGISR DILADLIPK DVSDEKLR DYIWNTLNSGR GLVYETSVLDPDEGIR HLPNDPMFK IVPNVLLEQGK VVPGYGHAVLR AGNASKDEIDSAVK ALIEVLQPLIAEHQAR DLTLDQAYSYAVENAK DMNQVLDAYENK GIDYDKLIVR ISFPAIQAAPSFSNSFPQIFR MSASDPNSSIFLTDTAK PNSEPASLLELFNSIATQGELVR ADLSGMSGAR EATTNAPFR FAYGYIEDLK FQSLNADINKR HNSSGSILFLGR IEEQLTLEK IPELLASGMVDNMTK KIEEQLTLEK LGVQDLFNSSK LVLVNAIYFK TFHFNTVEEVHSR TYGADLASVDFQHASEDAR TYGADLASVDFQHASEDARK TYNFLPEFLVSTQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
59.3 82.9 35.1 40.3 29.7 39.3 48.1 51.8 93.6 53.3 42.7 42.1 51.7 53.9 76.7 153.0 74.8 72.6 60.5 41.4 28.0 43.2 46.6 47.5 66.3 114.0 30.1 38.8 35.6 53.9 59.7 107.0 93.8 56.8 57.6 109.0 135.0 68.3 30.0 51.7 63.6 49.4 43.3 92.8 30.2 74.2 32.0 20.2 102.0 55.1 64.6
18.9 20.1 19.5 22.5 20.9 23.3 21.1 20.0 21.8 21.1 19.8 15.8 17.1 19.9 22.6 21.3 21.5 22.4 22.6 22.9 20.0 23.0 14.3 24.0 22.5 22.7 21.8 15.3 20.5 22.0 16.4 21.3 19.4 20.3 21.5 21.6 20.7 21.0 23.3 23.3 22.3 23.3 22.4 22.7 21.7 23.3 14.0 22.3 19.9 20.7 22.7
2 3 2 2 0 2 2 3 9 2 2 2 1 4 21 7 6 2 1 1 0 3 5 1 5 4 1 1 2 2 5 11 4 2 2 9 2 6 1 2 4 1 2 9 1 11 4 0 2 0 11
0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 1 6 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 4 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,365.60 1,333.75 1,354.76 1,168.60 2,416.10 1,232.61 908.50 1,022.46 1,731.90 1,811.94 915.56 853.53 2,143.18 1,601.88 1,263.60 1,930.00 1,351.75 1,419.75 1,690.83 1,390.69 1,127.66 865.45 997.59 961.50 1,338.64 1,762.89 1,098.54 1,209.72 1,167.66 1,404.70 1,801.03 1,800.87 1,455.64 1,191.67 2,325.20 1,800.83 2,485.29 964.45 1,006.50 1,218.60 1,305.69 1,287.68 1,102.60 1,650.81 1,230.69 1,207.63 1,179.71 1,602.77 2,052.93 2,181.02 1,686.87
Table S1 page 65/159
Cellular retinoic acid-binding protein RABP2_HUMAN CRABP2 2 Calmodulin
CALM_HUMAN CALM1
15,675
100.00%
3
3
5
16,820
100.00%
5
7
12
28.30% IAVAAASKPAVEIK SENFEELLK VGEEFEEQTVDGRPCK 50.30% DTDSEEEIREAFR EADIDGDGQVNYEEFVQMMTAK
Lysosomal protective protein
PPGB_HUMAN CTSA
54,450
100.00%
3
3
16
6.25%
Hornerin
HORN_HUMAN HRNR
282,355
100.00%
9
11
106
4.49%
Intercellular adhesion molecule 1
ICAM1_HUMAN ICAM1
57,807
100.00%
3
3
19
7.52%
Phosphoserine aminotransferase
SERC_HUMAN PSAT1
40,405
100.00%
9
11
33
24.10%
Scavenger mRNA-decapping enzyme DcpS Acylamino-acid-releasing enzyme
DCPS_HUMAN DCPS
38,592
99.90%
2
2
3
11.30%
ACPH_HUMAN APEH
81,206
100.00%
14
16
92
23.10%
EAFSLFDKDGDGTITTK ELGTVMR VFDKDGNGYISAAELR DTVVVQDLGNIFTR YEKDTVVVQDLGNIFTR YGDSGEQIAGFVK GPYESGSGHSSGLGHQESR GPYESGSGHSSGLGHR GSGSGQSPSSGQHGTGFGR GSGSGQSPSYGR HGSSSGSSSSYGQHGSGSR QSLGHGQHGSGSGQSPSPSR QSPSYGR SGSGWSSSR YGQQGSGSGQSPSR DGTFPLPIGESVTVTR LLGIETPLPK VELAPLPSWQPVGK ALELNMLSLK DDLLGFALR ELLAVPDNYK FGTINIVHPK FGVIFAGAQK GDDALEKR IINNTENLVR LPHSVLLEIQK QVVNFGPGPAK IVFENPDPSDGFVLIPDLK VNEASGDGDGEDAVVILEK AESFFQTK ALDVSASDDEIAR CELLSDDSLAVSSPR GSTGFGQDSILSLPGNVGHQDVK
MGFAVLLVNYR QPALSAACLGPEVTTQYGGQYR
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
HCDH_HUMAN HADH
34,260
100.00%
4
5
14
QVLLSEPEEAAALYR SALYYVDLIGGK SFNLSALEK TPLLLMLGQEDR TPLLLMLGQEDRR TVHTEWTQR VTSVVVDVVPR VVFDSAQR 12.10% DTPGFIVNR GDASKEDIDTAMK LVEVIK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
27.4 40.4 50.2 40.3 32.2 68.8 35.7 109.0 88.6 28.0 83.1 56.7 90.5 28.7 62.5 29.1 45.5 37.1 42.0 43.3 56.5 46.2 60.5 74.6 42.9 44.0 37.2 54.3 35.1 72.1 36.0 40.0 60.5 132.0 53.0 94.4 79.7 68.9 32.9 81.7 96.5 79.1 30.4 89.4 41.9 32.4 90.4 40.2 32.3 55.0 31.8
14.0 22.5 21.1 18.8 17.6 22.4 23.8 22.2 22.6 21.3 21.3 19.3 20.4 18.8 20.8 18.6 21.6 21.3 19.3 20.5 22.6 12.6 19.6 21.5 23.9 23.4 19.4 20.2 22.3 23.8 16.4 21.0 20.2 21.4 20.6 24.3 22.2 21.7 21.8 22.3 22.8 21.6 21.4 22.5 19.9 21.6 18.1 23.1 24.0 21.2 14.8
0 2 0 1 1 2 2 2 8 0 7 0 2 0 11 0 0 8 2 1 7 5 7 7 6 1 1 1 1 4 2 4 2 1 2 12 1 2 1 1 12 15 1 25 0 1 5 4 2 5 1
1 0 2 0 0 2 0 2 0 1 0 9 19 1 0 1 47 0 0 0 0 0 0 0 0 0 2 0 0 0 4 0 0 0 0 0 0 6 0 2 0 0 0 0 2 0 0 0 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,367.83 1,108.55 1,879.85 1,596.71 2,490.08 1,844.89 821.42 1,754.87 1,576.83 1,997.03 1,370.66 1,928.85 1,584.72 1,747.78 1,139.51 1,808.75 1,947.90 794.38 910.40 1,395.63 1,688.89 1,080.67 1,520.85 1,147.64 1,019.55 1,161.62 1,125.64 1,037.58 903.45 1,185.66 1,276.76 1,113.61 2,115.10 1,916.91 957.47 1,361.66 1,648.79 2,313.15 1,298.69 2,367.14 1,688.89 1,298.70 1,008.54 1,401.74 1,541.85 1,157.57 1,169.69 921.48 1,018.53 1,380.63 700.46
Table S1 page 66/159
Kinectin
KTN1_HUMAN KTN1
156,258
100.00%
30
33
68
Attractin
ATRN_HUMAN ATRN
158,518
100.00%
12
13
76
Fibroblast growth factor-binding protein 1
FGFP1_HUMAN FGFBP1
26,246
100.00%
5
7
160
CAD protein
PYR1_HUMAN CAD
242,965
100.00%
4
4
5
TFESLVDFSK 25.20% AHVQEVAQHNLK ALKEEIGNVQLEK AQQSLELIQSK DAVSNTTNQLESK EVIDLLKPDQVEGIQK GELTTLIHQLQEK ILNDQNK LLEEQLQHEISNK LMQLMESEQK LQALANEQAAAAHELEK LQQEEVQKK LQTLVSEQPNKDVVEQMEK NAEQAATQLK QMQSSFTSSEQELER QQNYQQASSFPPHEELLK QQQVEAVELEAK QSAELNK QTEDSLASER QTEDSLASERDR STYVTEVR SVEELLEAELLK SVEQEENKWK SVLAETEGILQK TAEHEAAQQDLQSK TENSSLTK TQLLQDVQDENK VQELQNLLK VQLQEAER WEEVQSYIR WLQDLQEENESLK 8.96% CTWLIEGQPNR DLDMFINASK EEYSNLKLPR IMQSSQSMSK LTGSSGFVTDGPGNYK LTLTPWVGLR NHNALLASLTTQK SEAACLAAGPGIR SVNNVVVR TLDHDR YDVDTQMWTILK YGHSLALYK 21.40% DTLGNTQIK KDFPESSLK LVSSTLFGNTKPR VVSEQKDTLGNTQIK WAATEQEEGISLK 2.20% EATAGNPGGQTVR LALGIPLPELR MALLATVLGR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
61.5 40.1 58.8 68.5 90.9 58.9 34.5 30.7 75.1 33.2 69.9 49.2 42.2 50.8 112.0 35.7 59.5 41.7 47.4 28.9 33.4 76.0 41.6 89.2 69.7 33.4 78.3 38.4 50.3 50.4 63.6 67.2 40.8 35.9 53.3 95.5 61.7 81.3 64.7 38.1 30.5 77.1 27.3 63.2 33.0 91.8 96.9 95.1 36.7 31.8 32.2
22.4 22.2 21.1 22.6 22.0 17.9 20.3 22.5 21.6 21.2 21.8 23.6 22.0 22.9 19.3 22.7 22.4 24.9 21.2 20.9 19.5 21.6 22.5 22.4 22.1 22.3 22.3 19.9 21.4 22.8 23.0 22.0 21.8 22.9 19.5 22.1 19.1 20.4 21.8 22.9 19.2 22.0 21.4 24.0 22.5 20.1 20.9 23.5 21.8 7.8 20.3
4 0 2 5 4 2 1 1 2 2 1 1 0 2 3 0 1 1 2 0 1 2 2 4 5 1 2 3 4 2 2 4 2 1 6 19 12 5 8 3 1 7 0 20 3 38 8 75 1 1 1
0 1 2 0 0 1 0 0 0 0 1 0 3 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 1 0 0 11 5 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,172.58 1,373.73 1,470.82 1,244.69 1,406.68 1,824.01 1,509.83 844.45 1,580.83 1,268.59 1,806.94 1,129.62 2,231.12 1,073.56 1,802.79 2,144.04 1,371.71 789.41 1,135.52 1,406.65 954.49 1,372.76 1,276.62 1,287.72 1,555.74 879.44 1,430.71 1,084.64 972.51 1,209.59 1,631.79 1,373.66 1,169.55 1,248.66 1,142.52 1,599.77 1,155.69 1,410.77 1,272.64 886.51 756.36 1,528.74 1,051.56 989.53 1,050.55 1,419.80 1,659.89 1,461.72 1,257.62 1,191.75 1,060.62
Table S1 page 67/159
Serum albumin
ALBU_HUMAN ALB
69,349
100.00%
23
27
1376
Transaldolase
TALDO_HUMAN TALDO1
37,524
100.00%
20
24
197
Actin-like protein 6A
ACL6A_HUMAN ACTL6A
47,443
100.00%
4
4
10
Protein S100-A2
S10A2_HUMAN S100A2
11,099
100.00%
4
5
8
VLGTSPEAIDSAENR 38.40% AACLLPK AAFTECCQAADK AVMDDFAAFVEK CCTESLVNR DDNPNLPR DVFLGMFLYEYAR FKDLGEENFK FQNALLVR KVPQVSTPTLVEVSR LKECCEKPLLEK LVAASQAALGL LVNEVTEFAK LVTDLTK QNCELFEQLGEYK QTALVELVK RHPDYSVVLLLR SLHTLFGDK TCVADESAENCDK TYETTLEK VFDEFKPLVEEPQNLIK VPQVSTPTLVEVSR YICENQDSISSK YLYEIAR 48.10% AAQASDLEK ALAGCDFLTISPK EAGISKDR FAADAVK IHLDEK ILDWHVANTDK ILDWHVANTDKK KFAADAVK KLGGSQEDQIK LGGSQEDQIK LIELYK LLGELLQDNAK LSDGIRK LSFDKDAMVAR LSSTWEGIQAGK MESALDQLK SYEPLEDPGVK TIVMGASFR VSTEVDAR WLHNEDQMAVEK 11.40% IPEGLFDPSNVK LIANNTTVER QGGPTYYIDTNALR VDFPTAIGMVVER 27.60% ELPSFVGEK ELPSFVGEKVDEEGLK VDEEGLKK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
98.5 36.6 53.6 68.9 53.0 32.7 39.2 52.4 53.2 104.0 56.1 69.3 64.2 55.6 75.9 54.3 39.1 32.1 96.6 34.8 58.5 84.9 51.9 46.6 68.2 83.2 47.0 49.4 33.2 65.4 64.2 31.2 32.9 56.5 46.9 77.8 46.9 62.5 88.6 43.9 36.0 37.7 59.2 61.3 31.1 55.6 74.9 41.6 36.6 86.8 40.1
22.7 24.7 14.6 20.8 18.1 22.0 22.3 22.8 19.8 16.1 22.5 17.6 22.8 21.1 21.1 21.2 17.6 23.9 8.5 21.1 20.0 20.3 19.4 21.0 23.6 22.4 24.5 23.0 18.8 22.7 20.2 20.6 23.9 23.9 13.8 21.3 22.2 22.7 23.3 23.1 22.6 22.3 23.6 21.5 22.9 23.8 22.6 22.8 21.9 22.6 23.6
2 11 4 22 36 3 2 8 38 264 11 2 44 70 2 9 0 1 3 1 17 88 52 194 4 13 5 3 1 2 5 1 1 8 9 45 4 12 24 8 6 14 10 10 1 4 4 1 1 2 2
0 0 0 0 0 0 0 4 0 444 4 0 0 0 0 0 8 0 0 0 34 0 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 2 0 0 0 0 0 7 0 0 0 0 0 1 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,558.77 772.44 1,371.57 1,342.64 1,138.50 940.45 1,639.78 1,226.61 960.56 1,639.94 1,546.80 1,013.60 1,149.62 789.47 1,657.75 1,000.60 1,467.84 1,017.54 1,498.58 984.49 2,045.10 1,511.84 1,443.64 927.49 932.47 1,392.72 875.46 721.39 754.41 1,311.67 1,439.76 849.48 1,202.64 1,074.54 778.47 1,213.68 788.46 1,252.64 1,276.65 1,050.51 1,233.60 981.52 876.44 1,499.70 1,315.69 1,130.62 1,568.77 1,433.75 1,005.53 1,775.91 917.49
Table S1 page 68/159
Peptidyl-prolyl cis-trans isomerase C PPIC_HUMAN PPIC
22,746
99.50%
2
2
14
Receptor-type tyrosine-protein phosphatase U
PTPRU_HUMAN PTPRU
162,407
100.00%
4
4
19
Transportin-3
TNPO3_HUMAN TNPO3
104,186
100.00%
2
3
6
Elongation factor 1-beta
EF1B_HUMAN EEF1B2
24,746
100.00%
3
3
19
Serine protease 23
PRS23_HUMAN PRSS23
42,984
100.00%
4
5
13
Soluble calcium-activated nucleotidase 1
CANT1_HUMAN CANT1
44,822
100.00%
7
7
24
Carcinoembryonic antigen-related cell adhesion molecule 1
CEAM1_HUMAN CEACAM1
57,542
100.00%
3
3
32
Brain-specific serine protease 4
BSSP4_HUMAN PRSS22
33,713
100.00%
3
3
22
Protein TFG
TFG_HUMAN TFG
43,430
99.50%
2
2
4
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
PIMT_HUMAN PCMT1
24,633
100.00%
5
5
9
Dickkopf-related protein 1
DKK1_HUMAN DKK1
28,653
100.00%
4
5
16
Apoptosis-associated speck-like protein containing a CARD
ASC_HUMAN PYCARD
21,610
100.00%
6
6
11
Tropomyosin alpha-4 chain
TPM4_HUMAN TPM4
28,504
100.00%
3
3
6
YSCQEGDKFK 9.91% IVIGLFGK TVENFVALATGEK 3.32% FLATFPLAAVSR GAPISVYQVIVEEER LVLTNPEGR QSGALVPAAGVR 3.90% SLDSFLLSPEAAVGLLK SVDPENNPTLVEVLEGVVR 18.20% KPALVAK LEECVR SIQADGLVWGSSK SPAGLQVLNDYLADK 17.20% DFLLNYPFSTSVK GNANDIGMDYDYALLELK LEVSSSCGPQCHK LPVVLPQSTLNLAKPDFGAEAK 23.20% AEWLAVKDER AQEENTWFSYLK AVPWVILSDGDGTVEK EWTTTTGDVVNENPEWVK GMELSDLIVFNGK TGVVYQIEGSK VASYIMAFTLDGR 8.94% QIVGYAIGTQQATPGPANSGR TIIVTELSPVVAKPQIK TLTLLSVTR 13.60% IVQGVQLR VGVAWVEPHPVYSWK VVGGEDSTDSEWPWIVSIQK 9.75% LLDSLEPPGEPGPSTNIPENDTVDGREEK LLSNDEVTIK 33.50% ALDVGSGSGILTACFAR LILPVGPAGGNQMLEQYDK MKPLMGVIYVPLTDKEK SGGASHSELIHNLR VQLVVGDGR 12.00% GQEGSVCLR GSHGLEIFQR KGSHGLEIFQR SSDCASGLCCAR 27.20% DLLLQALR ESQSYLVEDLER ESQSYLVEDLERS LLSVPLR VLTDEQYQAVR VTNVEWLLDALYGK 39.90% AEFAER AEVSELK EKAEGDVAALNR HIAEEADR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
35.1 40.9 106.0 56.1 97.5 37.6 38.1 47.6 74.4 39.0 37.8 70.8 120.0 54.7 80.6 52.0 73.4 31.4 57.8 98.1 102.0 37.6 54.8 62.0 113.0 37.0 64.0 40.8 57.7 84.2 38.7 65.8 57.6 59.4 29.3 48.3 33.2 33.3 41.5 41.1 40.7 39.9 65.9 57.8 30.0 84.0 61.8 30.5 33.9 63.8 38.5
18.4 9.5 22.2 18.9 22.6 18.8 19.3 17.5 20.2 12.0 22.9 22.5 22.6 22.5 20.6 19.0 14.0 23.4 21.1 22.2 21.3 22.9 22.5 23.4 22.1 9.5 13.2 15.2 21.9 21.5 19.9 23.0 22.4 21.4 20.0 23.5 20.0 22.2 22.7 21.7 9.0 16.5 22.5 21.0 12.3 22.6 21.2 22.0 25.1 22.7 22.0
2 2 12 9 6 1 3 2 2 1 1 6 12 4 4 2 2 1 3 9 4 1 4 2 6 1 25 9 0 6 0 2 2 2 0 0 1 2 2 0 3 2 2 2 1 2 2 1 1 2 4
0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 7 0 2 0 0 0 2 2 0 0 3 6 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,261.55 846.55 1,378.72 1,292.74 1,688.89 998.56 1,125.64 1,759.98 2,066.08 726.49 805.39 1,347.69 1,603.83 1,530.78 2,030.94 1,488.66 2,308.29 1,216.63 1,515.71 1,685.88 2,104.98 1,438.73 1,180.62 1,459.73 2,086.07 1,836.12 1,003.62 912.56 1,753.91 2,232.08 3,105.49 1,131.63 1,694.85 2,059.05 1,994.07 1,477.75 942.54 1,005.48 1,143.59 1,271.69 1,343.51 941.58 1,467.70 1,554.73 797.53 1,321.68 1,620.86 722.35 775.42 1,272.65 940.45
Table S1 page 69/159
Phosphoglycerate kinase 1
PGK1_HUMAN PGK1
44,597
100.00%
32
45
935
IQALQQQADEAEDR IQLVEEELDR IQLVEEELDRAQER KYEEVAR LEEAEKAADESER LKEAETR LVILEGELER RIQLVEEELDR YEEVAR 72.90% ACANPAAGSVILLENLR AGGFLMK AHSSMVGVNLPQK ALESPERPFLAILGGAK ALMDEVVK DCVGPEVEK DVLFLK ELNYFAK FHVEEEGKGK IQLINNMLDK IQLINNMLDKVNEMIIGGGMAFTFLK
ITLPVDFVTADK ITLPVDFVTADKFDENAK KYAEAVTR LGDVYVNDAFGTAHR LTLDKLDVK NNQITNNQR SLLGKDVLFLK SVVLMSHLGRPDGVPMPDK SVVLMSHLGRPDGVPMPDKYSLEPVAVELK
TGQATVASGIPAGWMGLDCGPESSK TGQATVASGIPAGWMGLDCGPESSKK
VADKIQLINNMLDK VDFNVPMK VDFNVPMKNNQITNNQR VLNNMEIGTSLFDEEGAK VLPGVDALSNI VNEMIIGGGMAFTFLK VSHVSTGGGASLELLEGK WNTEDKVSHVSTGGGASLELLEGK
Junctional adhesion molecule A
JAM1_HUMAN F11R
Procollagen-lysine,2-oxoglutarate 5- PLOD1_HUMAN PLOD1 dioxygenase 1
32,565
100.00%
6
6
27
83,535
100.00%
18
18
85
YAEAVTR YSLEPVAVELK 22.70% DGIVMPTNPK FDQGDTTR IPENNPVK ITASYEDR LIVLVPPSKPTVNIPSSATIGNR VTFLPTGITFK 33.40% AQVEEFLAQHGSEYQSVK FLGSGGFIGYAPNLSK FLLEYIAPMTEK IFLDPEKR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
75.6 69.4 50.9 30.6 77.8 42.4 41.3 32.9 38.1 106.0 51.7 64.1 82.0 51.0 49.2 42.5 38.3 36.8 52.5 50.3 54.8 100.0 51.4 105.0 45.5 52.8 44.0 42.9 26.2 80.3 50.2 70.8 55.8 40.3 101.0 66.6 76.2 106.0 61.5 53.1 65.8 30.8 43.3 38.2 51.5 45.7 40.0 94.9 107.0 69.9 38.1
21.9 22.3 21.9 22.4 21.9 24.5 20.3 21.9 22.0 20.4 22.2 22.6 17.3 23.9 18.8 15.7 21.5 22.2 23.4 20.0 20.3 21.4 20.8 22.5 17.3 21.5 9.0 22.4 18.5 20.3 21.4 21.0 22.8 22.7 22.0 18.7 22.5 21.6 21.1 22.5 21.6 22.0 18.6 19.6 20.6 4.8 16.8 22.3 21.9 22.4 21.9
3 10 7 1 11 6 2 2 3 5 22 24 38 7 10 2 6 3 6 0 1 67 2 25 6 15 2 0 0 1 0 4 13 2 153 39 40 47 0 25 22 1 3 5 5 0 4 6 5 7 1
0 0 6 0 7 0 0 2 0 1 0 10 52 0 0 0 0 18 0 3 0 40 0 76 0 0 0 8 0 2 5 4 0 2 4 0 1 77 33 0 0 0 0 0 0 9 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,614.77 1,243.65 1,727.89 894.47 1,476.68 846.47 1,170.67 1,399.75 766.37 1,768.94 739.38 1,383.71 1,769.00 904.48 1,032.47 734.45 884.45 1,159.57 1,217.66 2,958.51 1,318.73 2,023.04 937.51 1,634.79 1,044.63 1,101.54 1,232.76 2,035.05 3,295.71 2,493.14 2,621.23 1,630.88 965.48 2,048.00 1,966.94 1,097.62 1,759.88 1,740.91 2,514.25 809.42 1,247.69 1,087.55 939.42 910.50 954.45 2,373.39 1,223.70 2,049.99 1,627.85 1,470.76 1,017.57
Table S1 page 70/159
Threonyl-tRNA synthetase, cytoplasmic
SYTC_HUMAN TARS
83,420
100.00%
33
37
191
IFQNLDGALDEVVLK IQALGLGEDWNVEK IQGGYENVPTIDIHMNQIGFER LDPDMAFCANIR LQLNYLGNYIPR LVAEWEGQDSDSDQLFYTK LVGPEVR NLAYDTLPVLIHGNGPTK NVIAPLMTR QQDVFMFLTNR SAQFFNYK SEDYVDIVQGR SQVVFSAEELIYPDR VGVWNVPYISNIYLIK 45.50% ADMETLQR AEHDSILAEK AELNPWPEYIYTR AILGSVER CGPLIDLCR ETLLAMFK FLGDIEVWDQAEK FNLTYVSHDGDDK FQEEAK GAYIYNALIEFIR GCLDFLR GFQEVVTPNIFNSR IDIQIK IYGISFPDPK KETLLAMFK LADFGVLHR LEMYNILK LNLSTRPEK MGGEEKPIGAGEEK MIAILTENYGGK NELSGALTGLTR NSSTYWEGK QLENSLNEFGEK QLENSLNEFGEKWELNSGDGAFYGPK
Nuclear mitotic apparatus protein 1
NUMA1_HUMAN NUMA1
238,242
100.00%
6
6
10
QVDAESWK QVMVVPVGPTCDEYAQK TISETIER TTPYQIACGISQGLADNTVIAK TVYSVFGFSFK VNTPTTTVYR VTLPDGK WELNSGDGAFYGPK WPFWLSPR 3.55% AALMESQGQQQEER ALQQVQEK AVQAQGGESQQEAQR DSALETLQGQLEEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0%
109.0 88.5 54.3 77.1 67.4 74.0 33.1 89.7 30.2 62.6 36.1 82.0 40.8 50.0 64.4 49.9 57.3 56.8 60.3 42.7 68.7 67.1 32.3 78.3 31.5 71.8 32.3 63.7 37.6 60.4 39.0 32.9 59.1 62.2 97.8 39.7 67.8 90.1 41.4 67.5 39.7 103.0 35.9 38.7 32.5 60.9 46.6 67.6 30.1 86.3 48.0
20.5 21.3 21.5 20.8 20.7 21.1 17.2 19.8 23.4 22.7 22.6 22.3 22.0 16.1 22.0 21.4 22.7 23.7 22.5 20.7 22.7 19.6 23.2 20.9 23.2 23.2 20.5 22.2 19.7 20.3 21.1 22.2 20.6 22.5 22.5 18.9 22.1 20.1 21.3 21.8 23.8 20.9 22.7 22.5 21.1 20.8 23.9 19.7 20.6 22.2 23.0
13 4 0 2 7 11 2 3 1 8 1 8 1 1 6 5 8 3 2 4 13 2 1 9 1 12 2 25 2 2 3 0 10 6 17 2 2 0 3 4 5 4 2 1 3 2 11 4 1 1 1
0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 1 0 0 2 8 0 0 0 0 4 0 0 0 2 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,673.91 1,571.81 2,531.24 1,438.65 1,463.80 2,231.01 769.46 1,923.03 1,030.57 1,398.68 1,004.48 1,280.61 1,752.88 1,878.05 963.46 1,112.56 1,651.81 844.49 1,103.53 968.51 1,549.75 1,510.68 751.36 1,542.83 880.44 1,607.82 729.45 1,136.60 1,080.61 1,027.57 1,023.56 1,057.60 1,447.67 1,309.68 1,231.66 1,071.47 1,407.68 2,929.36 962.46 1,936.92 948.50 2,321.18 1,281.65 1,151.61 729.41 1,540.71 1,088.57 1,620.73 943.52 1,586.75 1,560.78
Table S1 page 71/159
Disintegrin and metalloproteinase domain-containing protein 15 von Willebrand factor A domaincontaining protein 1
ADA15_HUMAN ADAM15
87,726
99.50%
2
2
4
VWA1_HUMAN VWA1
46,786
100.00%
4
4
5
Eukaryotic translation initiation factor 3 subunit I
EIF3I_HUMAN EIF3I
36,484
100.00%
4
4
7
Epithelial discoidin domaincontaining receptor 1 Septin-7
DDR1_HUMAN DDR1
101,112
99.90%
2
2
5
SEPT7_HUMAN SEPT7
50,662
100.00%
6
6
13
Tropomyosin alpha-3 chain
TPM3_HUMAN TPM3
32,802
100.00%
4
4
15
36,244
99.50%
2
2
3
71,827
100.00%
3
3
7
DSAQTSVTQAQR LLQAETASNSAR 3.69% SYTLEQGPGDLQGPPIISR VLQTSLPEPLR 15.70% EFVGQLVAPLPLGTGALR EQLFAEASGARPGVPK MGDTHTGLALVYAK VLVWVTDGGSSDPVGPPMQELK
Four and a half LIM domains protein FHL1_HUMAN FHL1 1 TNR21_HUMAN TNFRSF21 Tumor necrosis factor receptor superfamily member 21 Importin-9
IPO9_HUMAN IPO9
115,946
99.90%
2
2
3
Collagen alpha-1(VII) chain
CO7A1_HUMAN COL7A1
295,200
100.00%
14
15
84
13.80% DPSQIDNNEPYMK LFDSTTLEHQK QINDIQLSR SYSSGGEDGYVR 2.19% DRWGQEVISGNEDPEGVVLK WGQEVISGNEDPEGVVLK 15.30% DVTNNVHYENYR FEDYLNAESR NLEGYVGFANLPNQVYR SPLAQMEEERR TVQVEQSK VNIIPLIAK 34.50% AADAEAEVASLNR AEFAER HIAEEADR IQLVEEELDR IQLVEEELDRAQER KLVIIEGDLER KYEEVAR LDKENALDR LEEAEKAADESER LKEAETR MELQEIQLK RIQLVEEELDR YEEVAR 7.12% AIVAGDQNVEYK QVIGTGSFFPK 5.19% GPEASLAQLISALR GTETEDVR GTFSDVPSSVMK 3.27% EALVDTLTGILSPVQEVR YSNDPVVASLAQDIFK 6.56% DLVLSEPSSQSLR EGSASVLTVR FATVQYSDDPR GATGVQGER GPGQEVPGSPQTLPGISSSQR LSVLGPAGEGPSAEVTAR QEVNVPAGETSVR SFLEGLVLPFSGAASAQGVR SQDLVDTAAQR VLSGGPTQQQELGPGQGSVLLR VPSIELR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
38.2 40.5 74.7 31.0 38.0 29.0 31.6 69.8 51.0 44.7 34.4 54.2 42.2 92.0 71.4 66.7 61.7 26.4 33.8 39.9 60.6 30.5 38.5 69.4 50.9 41.8 30.6 32.3 77.8 42.4 56.2 32.9 38.1 44.2 36.8 50.8 33.1 45.8 48.8 38.1 54.3 37.2 37.3 41.6 73.3 70.1 59.4 55.8 56.4 89.5 36.3
22.6 23.3 21.0 17.7 15.6 21.8 22.7 21.4 16.6 23.1 22.0 16.7 21.7 22.2 20.9 20.3 21.6 24.2 23.7 9.5 21.8 22.0 22.0 22.3 21.9 18.3 22.4 23.4 21.9 24.5 23.9 21.9 22.0 23.2 21.6 19.3 21.1 21.4 18.5 21.8 21.8 23.4 20.8 21.7 22.6 21.0 22.3 19.7 23.2 19.5 17.9
2 1 3 1 2 0 0 1 2 2 1 2 0 4 2 2 1 0 1 6 5 1 4 10 7 1 1 0 11 6 5 2 3 2 1 2 2 3 2 1 9 1 2 1 6 14 13 1 11 4 3
0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 6 0 0 2 7 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,291.62 1,260.65 2,028.04 1,252.73 1,838.05 1,656.87 1,492.75 2,327.16 1,566.67 1,318.66 1,086.59 1,276.54 2,227.10 1,955.97 1,523.69 1,243.56 1,953.98 1,361.65 918.49 980.65 1,316.64 722.35 940.45 1,243.65 1,727.89 1,284.75 894.47 1,073.56 1,476.68 846.47 1,131.61 1,399.75 766.37 1,306.66 1,180.64 1,425.81 906.42 1,270.60 1,940.07 1,766.90 1,430.75 1,018.55 1,298.60 874.44 2,079.05 1,710.90 1,385.70 2,006.07 1,203.60 2,221.19 813.48
Table S1 page 72/159
Alpha-mannosidase 2
MA2A1_HUMAN MAN2A1
131,128
100.00%
10
10
21
Phosphoglycerate kinase 2
PGK2_HUMAN PGK2
44,779
99.50%
2
2
13
Glucose-6-phosphate isomerase
G6PI_HUMAN GPI
63,130
100.00%
23
29
381
VQYTPLTGLGQPLPSER VSWSPVPGATQYR VVVSDATR 10.50% FLSSSLYTALTEAR FYTDLNGYQIQPR GLEQGIQDNK ILESASSNSHLADYVLYK ITANLFR LLAENNEIISNIR NYQQLFDYMNSQSK SQDSLPQK VLLAPLGDDFR YLVVYNPLEQDR 19.70% DVLFLK LGDVYVNDAFGTAHR NQITNNQR SLLGKDVLFLK VDFNVPMK VNEMIIGGGMAYTFLK VSHVSTGGGASLELLEGK WNTEDKVSHVSTGGGASLELLEGK
42.50% AVLHVALR DPQFQK DVMPEVNK ELQAAGK EWFLQAAK FAAYFQQGDMESNGK HFVALSTNTTK ILLANFLAQTEALMR INYTEGR KELQAAGK KIEPELDGSAQVTSHDASTNGLINFIK
LFDANKDR LTPFMLGALVAMYEHK MLVDLAK NLVTEDVMR SELNLR SNTPILVDGKDVMPEVNK SPEDLER TFTTQETITNAETAK TFTTQETITNAETAKEWFLQAAK
AN32A_HUMAN ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A
28,568
100.00%
10
11
42
TLAQLNPESSLFIIASK VFEGNRPTNSIVFTK VWYVSNIDGTHIAK 35.70% CPNLTHLNLSGNK DLSTIEPLK ELVLDNSR IKDLSTIEPLK KLELSDNR LLPQLTYLDGYDR LLPQLTYLDGYDRDDK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
95.4 45.1 40.4 82.8 42.7 51.1 30.9 30.5 75.2 66.6 33.2 42.6 46.4 42.5 105.0 32.9 44.0 55.8 46.3 106.0 61.5 41.5 35.9 31.9 33.0 48.4 86.3 55.4 97.3 39.8 45.9 51.9 33.3 56.9 37.7 52.5 33.3 58.6 48.9 119.0 66.2 108.0 42.3 72.5 39.5 33.0 41.8 50.2 51.6 69.2 35.1
19.9 23.4 24.5 23.2 22.2 22.2 21.5 21.8 21.3 20.0 22.5 22.0 23.0 15.7 22.5 20.9 9.0 22.8 22.5 21.6 21.1 9.0 23.3 22.3 23.6 23.1 19.3 23.1 19.2 22.7 23.7 19.2 24.0 21.9 21.0 22.6 25.1 22.3 19.5 21.9 21.1 16.8 21.4 22.8 23.2 21.5 23.2 17.5 22.8 21.9 22.8
12 3 2 2 2 4 0 1 4 1 1 3 2 2 25 1 2 13 12 47 0 3 4 1 1 12 6 10 69 7 3 0 2 4 4 12 5 8 15 69 1 57 6 14 0 3 5 6 3 4 1
0 0 0 0 0 0 1 0 0 0 0 0 0 0 76 0 0 0 0 77 33 0 0 0 0 0 0 0 28 0 0 16 0 0 0 0 0 7 0 1 8 2 0 6 2 0 0 3 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,855.99 1,447.73 846.47 1,558.81 1,614.79 1,101.55 2,010.02 834.48 1,498.82 1,781.78 902.46 1,215.67 1,508.78 734.45 1,634.79 987.50 1,232.76 965.48 1,759.88 1,740.91 2,514.25 878.56 762.38 947.45 716.39 992.52 1,692.73 1,218.65 1,719.95 852.42 844.49 2,884.47 978.50 1,852.93 805.45 1,092.54 731.41 1,972.01 845.40 1,655.81 2,629.32 1,832.02 1,708.90 1,602.83 1,467.74 1,015.57 945.50 1,256.75 974.53 1,566.82 1,924.97
Table S1 page 73/159
Hypoxia up-regulated protein 1
HYOU1_HUMAN HYOU1
111,319
100.00%
4
4
7
Phosphoglycolate phosphatase
PGP_HUMAN PGP
33,989
100.00%
3
3
6
14-3-3 protein beta/alpha
1433B_HUMAN YWHAB
28,065
100.00%
7
11
180
SLDLFNCEVTNLNDYR TPSDVKELVLDNSR VSGGLEVLAEK 5.81% AANSLEAFIFETQDK DAVVYPILVEFTR LGNTISSLFGGGTTPDAK LPATEKPVLLSK 11.80% GETAVPGAPEALR LGFITNNSSK TILTLTGVSTLGDVK 63.00% AVTEQGHELSNEER DNLTLWTSENQGDEGDAGEGEN
Biliverdin reductase A
BIEA_HUMAN BLVRA
33,411
100.00%
4
4
11
Ras-related protein Rab-10
RAB10_HUMAN RAB10
22,524
99.50%
2
2
4
Plectin-1
PLEC1_HUMAN PLEC1
531,766
100.00%
106
109
722
DSTLIMQLLR EMQPTHPIR KEMQPTHPIR LAEQAER LAEQAERYDDMAAAMK NLLSVAYK NLLSVAYKNVVGAR QTTVSNSQQAYQEAFEISK QTTVSNSQQAYQEAFEISKK TAFDEAIAELDTLNEESYK VISSIEQK YDDMAAAMK YLIPNATQPESK YLSEVASGDNK 16.20% FGFPAFSGISR GSLLFTAGPLEEER SGSLENVPNVGVNK SPLSWIEEK 22.50% AFLTLAEDILR LLLIGDSGVGK LQIWDTAGQER NIDEHANEDVER 24.20% AALAHSEEVTASQVAATK AALEEVER AGVAAPATQVAQVTLQSVQR AGVVGPELHEQLLSAEK AKLEQLFQDEVAK ALQALEELR APVPASELLASGVLSR AQAEQAALR AQLEPVASPAK AQVEQELTTLR ASDSELER DDGTGQLLLPLSDAR DPYSGSTISLFQAMQK DSQDAGGFGPEDR DTHDQLSEPSEVR EAEGQLQK EAQAVPATLPELEATK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
103.0 27.4 78.7 46.8 41.9 55.3 46.6 36.5 39.2 65.0 105.0 122.0 79.3 67.1 43.9 59.4 52.0 51.4 79.1 140.0 78.3 96.7 65.9 70.3 71.3 76.9 53.9 44.2 61.4 36.6 49.9 58.7 61.5 38.0 28.9 52.1 78.0 26.4 53.2 59.2 112.0 53.9 48.8 75.7 57.2 57.4 88.4 61.0 46.5 36.2 53.1
20.7 22.2 22.9 22.5 20.6 21.9 14.0 21.9 21.7 16.8 21.6 14.3 21.3 22.4 22.5 21.6 20.8 19.1 17.7 22.0 22.2 21.5 22.9 14.5 23.7 21.7 22.0 23.0 21.6 23.1 20.6 20.3 22.2 18.6 21.5 22.2 17.1 20.9 22.0 21.5 18.0 21.1 19.8 23.1 21.1 22.0 21.8 14.9 21.2 22.5 19.9
5 0 8 0 2 1 2 1 2 3 27 4 113 13 0 36 4 49 4 65 2 14 27 11 14 26 2 3 4 2 3 2 7 1 0 7 2 0 2 14 22 2 5 13 5 6 3 13 1 5 5
0 2 0 2 0 0 0 0 0 0 9 0 0 0 11 0 1 0 2 2 11 6 0 0 0 0 0 0 0 0 0 0 0 0 1 0 10 1 0 0 1 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,972.91 1,572.82 1,101.62 1,683.82 1,521.83 1,735.89 1,295.79 1,267.66 1,080.57 1,517.88 1,598.74 2,350.96 1,189.66 1,108.56 1,252.65 816.42 1,812.83 907.53 1,503.86 2,159.03 2,287.12 2,159.00 903.52 1,015.42 1,360.71 1,182.56 1,185.61 1,518.78 1,413.73 1,088.56 1,261.72 1,071.64 1,316.66 1,440.64 1,783.92 916.47 1,995.10 1,776.95 1,518.82 1,042.59 1,566.89 957.51 1,110.62 1,287.69 906.42 1,570.81 1,772.85 1,350.56 1,512.69 902.46 1,667.89
Table S1 page 74/159
ELAQEQAR ELQNAGDR EQELQQTLQQEQSVLDQLR ESADPLGAWLQDAR FLEVQYLTGGLIEPDTPGR FPVTDAVNK FRELAEEAAR GAQEVGER GGAEGELQALR GGELVYTDSEAR GIYQSLEGAVQAGQLK GKAEEQAVR GTQGAEEVLR GYFSEEMNR GYYSPYSVSGSGSTAGSR HISDLYEDLR LAAEQELIR LAAIGEATR LAEDEAFQR LEDLLQDAQDEKEQLNEYK LEQLFQDEVAK LFNAIIHR LGFHLPLEVAYQR LISLFQAMK LKQSAEEQAQAR LLDAQLATGGIVDPR LLDPEDVDVPQPDEK LLEAAAQSTK LLFNDVQTLK LLLWSQR LQAEEAER LQAEEVAQQK LQEAGILSAEELQR LQEALR LQLEATER LQNVQIALDYLR LRAETEQGEQQR LSVAAQEAAR LSYTQLLR LTAEDLFEAR LVASMEEAR MQAVQEATR MQEEVVR NDDIADGNPK NLLDEELQR NLVDNITGQR QAEEIGEK QEQIQAMPLADSQAVR QLAAEEER QLAEEDAAR QLAEEDLAQQR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
56.9 50.4 124.0 87.9 84.1 31.8 29.4 59.1 90.5 59.1 81.3 34.5 40.6 35.0 81.6 39.1 40.0 46.2 64.9 48.9 49.6 54.7 29.5 36.1 60.9 59.4 82.8 46.5 53.8 41.9 46.6 48.4 87.2 32.0 41.5 77.8 54.8 65.2 62.8 59.6 42.4 62.2 42.9 55.8 53.1 54.5 40.1 69.7 45.4 65.0 75.8
21.0 20.8 21.4 22.0 21.2 23.3 23.7 20.7 22.5 22.2 21.0 22.4 22.1 12.6 19.0 22.0 20.1 24.1 22.7 21.5 23.0 16.0 21.1 19.7 22.9 19.1 22.5 23.3 20.0 20.3 20.1 23.0 22.2 23.3 22.5 19.2 22.7 22.4 17.2 23.5 22.5 22.1 22.2 17.6 23.2 23.0 22.1 21.3 20.1 20.0 21.9
14 5 6 29 4 2 0 5 11 2 6 1 2 1 1 2 2 11 13 0 1 4 0 1 0 4 11 3 6 5 8 16 4 1 3 4 6 5 3 4 3 11 5 7 6 2 4 1 6 7 19
0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 1 0 17 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
944.48 902.43 2,313.17 1,528.74 2,105.09 990.53 1,191.61 845.41 1,100.57 1,296.61 1,661.89 987.52 1,059.54 1,148.47 1,782.79 1,260.62 1,042.59 901.51 1,078.52 2,321.12 1,319.68 983.58 1,542.84 1,050.60 1,358.70 1,538.85 1,708.83 1,031.57 1,190.68 915.54 945.46 1,143.60 1,556.83 729.43 959.52 1,445.81 1,444.71 1,015.55 993.57 1,164.59 1,021.50 1,049.51 906.44 1,058.48 1,129.59 1,129.60 903.44 1,800.89 945.46 1,002.49 1,300.65
Table S1 page 75/159
Hypoxanthine-guanine phosphoribosyltransferase
HPRT_HUMAN HPRT1
24,562
100.00%
8
8
32
Receptor-type tyrosine-protein phosphatase S
PTPRS_HUMAN PTPRS
217,075
100.00%
4
4
12
Malate dehydrogenase,
MDHM_HUMAN MDH2
35,486
100.00%
17
21
365
QLAEGTAQQR QLEMSAEAER QLLEEELAR QLQLAQEAAQK QLQLAQEAAQKR QQEELLAEENQR QQGLASYDYVR QSAEEQAQAR QSSEAEIQAK QTNLENLDQAFSVAER QVAEEAAR QVEEEILALK QVQVALETAQR RAAEEAEEAR RPELEDSTLR RQELEAELAK RQEQIQAMPLADSQAVR SAEAELQSK SELELTLGK SIITYVSSLYDAMPR SIQEELQQLR SKEQAELEAAR SLAAEEEAAR SLESLHSFVAAATK SLQEEHVAVAQLR SLSAIYLEK SLVPAAELLESR SMVEEGTGLR SNAEDTLR SQVEEELFSVR SSIAGLLLK SWSLATFR VAQLLER VKAEAEAAR VLALPEPSPAAPTLR VPDVQDGVR VQSGSESVIQEYVDLR WQAVLAQTDVR 39.40% FFADLLDYIK NVLIVEDIIDTGK SIPMTVDFIR SYCNDQSTGDIK TMQTLLSLVR VASLLVK VFIPHGLIMDR VIGGDDLSTLTGK 2.77% SPQGLGAFTPVVR TDEDVPSAPPR TGEQAPASAPR VLAFTSVGDGPLSDPIQVK 62.70% AGAGSATLSMAYAGAR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
64.7 53.5 40.4 74.8 45.3 85.0 38.6 48.9 61.3 134.0 38.6 64.6 46.3 35.6 41.9 33.1 46.7 63.2 33.4 63.7 75.4 37.1 72.1 83.3 40.4 40.7 45.9 47.4 46.2 86.4 46.9 37.6 46.6 38.8 58.3 34.3 101.0 61.0 60.9 72.9 32.0 45.5 64.5 32.6 41.0 93.2 53.6 32.6 66.8 85.9 112.0
20.5 20.4 23.1 21.7 20.3 22.1 21.7 20.4 23.7 23.6 21.8 22.7 22.9 20.5 23.3 22.4 22.1 23.5 22.0 21.8 22.3 23.3 22.1 22.6 22.1 19.4 21.1 21.3 22.5 22.9 15.8 22.9 20.7 23.1 16.7 21.3 22.5 23.2 22.4 21.2 23.2 16.6 19.8 19.1 20.5 22.6 20.7 21.5 22.4 20.3 22.0
12 9 8 12 1 5 2 2 6 16 6 15 5 1 4 2 0 15 1 9 18 0 24 4 0 5 4 2 3 9 7 4 4 3 22 2 6 16 5 4 2 2 9 2 0 3 2 1 6 3 74
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 6 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,101.57 1,179.53 1,100.60 1,227.67 1,383.77 1,486.71 1,299.63 1,117.52 1,090.54 1,834.89 873.44 1,171.66 1,242.68 1,131.54 1,215.63 1,186.64 1,956.99 962.48 989.55 1,731.86 1,243.66 1,231.63 1,046.51 1,460.77 1,479.79 1,023.57 1,284.72 1,094.52 905.43 1,322.66 901.57 967.50 828.49 944.52 1,531.89 984.51 1,808.90 1,286.69 1,244.66 1,428.80 1,178.62 1,387.58 1,161.67 729.49 1,297.71 1,275.68 1,328.73 1,183.56 1,084.54 1,943.05 1,454.71
Table S1 page 76/159
mitochondrial
Protein jagged-1
JAG1_HUMAN JAG1
133,778
100.00%
8
9
26
ANTFVAELK FVFSLVDAMNGK GCDVVVIPAGVPR GYLGPEQLPDCLK HGVYNPNK IFGVTTLDIVR IQEAGTEVVK KGEDFVK LTLYDIAHTPGVAADLSHIETK MISDAIPELK SQETECTYFSTPLLLGK TIIPLISQCTPK VAVLGASGGIGQPLSLLLK VDFPQDQLTALTGR VNVPVIGGHAGK VSSFEEK 7.96% ASHSGMINPSR CVCPPQWTGK DDGNPIKEITDK DLVNDFYCDCK IIDLVSKR SSSLQPVK VTAGGPCSFGSGSTPVIGGNTFNLK
YISSNVCGPHGK Cadherin-3
Cytoplasmic aconitate hydratase
CADH3_HUMAN CDH3
ACOC_HUMAN ACO1
91,401
98,383
100.00%
100.00%
6
9
7
11
58
24
14.70%
DPAGWLAMDPDSGQVTAVGTLDREDEQFVR
ETGWLLLNKPLDREEIAK GLDFEAK IFYSITGPGADSPPEGVFAVEK LTVTDLDAPNSPAWR STGTISVISSGLDR YEAHVPENAVGHEVQR 17.40% FVEFFGPGVAQLSIADR GPFLLGIK IDFEKEPLGVNAK IETVNESWNALATPSDK QAPQTIHLPSGEILDVFDAAER SNLVGMGVIPLEYLPGENADALGLTGQER
Elongation factor 2
EF2_HUMAN
EEF2
95,322
100.00%
25
27
126
SPPFFENLTLDLQPPK VILQDFTGVPAVVDFAAMR YQQAGLPLIVLAGK 31.90% ALLELQLEPEELYQTFQR ARPFPDGLAEDIDKGEVSAR CLYASVLTAQPR EDLYLKPIQR EGIPALDNFLDKL FSVSPVVR GEGQLGPAER GGGQIIPTAR GHVFEESQVAGTPMFVVK GPLMMYISK IKPVLMMNK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8%
83.3 87.8 71.3 54.5 39.7 66.0 46.8 48.3 99.3 72.9 106.0 65.3 129.0 108.0 52.3 35.8 45.4 36.2 34.9 75.6 40.6 58.8 98.7 52.0 56.6 29.2 41.4 123.0 77.7 96.4 67.3 74.2 44.1 52.5 84.6 38.2 30.1 67.1 99.2 65.1 94.1 60.9 55.6 35.8 69.5 35.2 46.4 38.3 39.9 63.4 26.4
21.7 22.4 21.4 23.2 21.1 17.3 23.5 22.4 18.9 23.6 22.1 19.9 3.0 22.9 17.7 21.5 20.7 18.2 22.6 13.2 17.1 23.4 22.1 21.3 19.3 17.6 23.6 21.3 21.7 21.8 23.4 21.3 21.2 22.6 22.1 20.8 20.5 21.3 21.0 14.9 20.8 22.1 22.5 19.9 22.4 20.6 21.1 20.3 22.4 22.0 22.0
15 11 5 6 2 36 9 2 2 24 3 2 61 32 9 4 2 2 0 6 2 6 2 2 0 0 2 16 13 22 0 2 3 2 2 0 0 2 2 3 3 0 2 1 24 2 10 4 0 8 0
0 0 0 0 0 0 0 0 50 0 0 0 2 0 15 0 3 0 1 0 0 0 0 0 1 2 0 0 0 0 2 0 0 2 0 3 1 0 2 0 1 3 0 0 0 0 0 0 2 0 1
0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
992.54 1,343.67 1,338.72 1,489.74 928.46 1,233.72 1,073.58 822.44 2,365.24 1,116.60 1,973.95 1,370.77 1,793.09 1,560.80 1,147.66 825.40 1,172.55 1,232.56 1,344.67 1,448.58 943.59 845.47 2,425.18 1,318.62 3,291.52 2,125.17 779.39 2,281.14 1,655.84 1,392.73 1,834.88 1,852.96 844.53 1,459.78 1,874.91 2,407.23 3,029.53 1,842.96 2,065.08 1,470.87 2,220.16 2,143.08 1,378.72 1,274.71 1,444.77 890.51 1,013.50 969.55 1,977.97 1,055.53 1,089.62
Table S1 page 77/159
IMGPNYTPGKK IWCFGPDGTGPNILTDITK KEDLYLKPIQR KIWCFGPDGTGPNILTDITK MVNFTVDQIR QFAEMYVAK SDPVVSYR TFCQLILDPIFK TGTITTFEHAHNMR VFDAIMNFK VFSGLVSTGLK VNFTVDQIR WLPAGDALLQMITIHLPSPVTAQK
Cullin-associated NEDD8dissociated protein 1
CAND1_HUMAN CAND1
136,363
100.00%
12
12
26
Proteasome subunit beta type-8
PSB8_HUMAN PSMB8
30,337
100.00%
6
7
15
Exostosin-2
EXT2_HUMAN EXT2
82,238
100.00%
5
5
11
Nucleoredoxin
NXN_HUMAN NXN
48,376
100.00%
4
4
8
Protein MEMO1
MEMO1_HUMAN MEMO1
33,716
100.00%
2
2
2
97,134
100.00%
11
11
21
YEWDVAEAR 12.80% AADIDQEVKER ALTLIAGSPLK DLLDTVLPHLYNETK EGPAVVGQFIQDVK ITSEALLVTQQLVK LGTLSALDILIK LTLIDPETLLPR MLTGPVYSQSTALTHK SVILEAFSSPSEEVK TVSPALISR TYIQCIAAISR VIRPLDQPSSFDATPYIK 24.30% AIAYATHR ASAGSYISALR FQHGVIAAVDSR ISVSAASK KGPGLYYVDEHGTR VESTDVSDLLHQYR 7.52% ADPVLYKDDFPEK FASVFGTMPLK HGESVLVLDK LLVVWNNQNK LPADSPIPER 15.90% DYTNLPEAAPLLTILDMSAR EVIAGPLLR ISNIPSLIFLDATTGK LRGDAAAGPGPGAGAGAAAEPEPR
Glycogen phosphorylase, liver form PYGL_HUMAN PYGL
6.40% TGMFER YSYYDESQGEIYR 19.40% DFNVGDYIQAVLDR EYAQNIWNVEPSDLK EYYEALPELK FSQFLETEYK IDDVAALDKK INPSSMFDVQVK LITSVADVVNNDPMVGSK LVIDQIDNGFFSPK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
30.3 89.0 45.7 29.0 46.7 41.7 32.2 58.5 38.9 43.0 84.6 80.2 44.4 63.6 38.1 57.0 39.0 49.1 73.6 33.6 67.4 27.9 65.8 30.9 48.5 44.6 33.4 91.5 50.7 51.7 28.0 75.9 51.5 50.4 44.6 38.4 61.5 50.8 41.6 72.6 62.5 34.2 52.4 87.8 48.0 30.9 68.3 28.3 52.3 108.0 65.4
22.4 21.8 18.3 21.5 22.8 21.1 22.6 21.5 20.4 20.8 18.8 23.8 16.3 19.4 23.3 17.4 22.0 21.9 14.3 13.0 15.3 22.8 22.1 21.4 21.6 20.2 22.2 21.8 22.2 21.8 22.7 22.8 22.4 21.9 21.0 20.8 20.9 22.4 13.0 18.1 21.8 16.7 16.6 22.8 22.8 22.6 22.8 23.4 22.9 21.8 22.2
0 2 0 0 2 3 2 5 0 2 17 12 0 5 1 3 1 2 2 1 8 0 2 1 2 0 1 2 2 2 0 2 2 3 1 1 4 1 1 4 0 1 1 3 2 1 2 0 2 4 1
3 0 2 1 0 0 0 0 4 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 2 0 0 0 0 2 4 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 1 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,221.63 2,105.04 1,402.81 2,233.13 1,238.62 1,102.52 922.46 1,494.80 1,615.77 1,100.55 1,107.64 1,091.59 2,616.42 1,138.52 1,273.64 1,083.68 1,770.93 1,486.79 1,542.91 1,256.78 1,380.81 1,749.88 1,621.83 943.56 1,295.68 2,047.09 902.48 1,095.58 1,299.68 762.44 1,591.79 1,661.81 1,536.76 1,197.63 1,096.60 1,227.69 1,094.58 2,220.12 967.59 1,689.94 2,116.05 756.34 1,672.71 1,624.80 1,805.87 1,254.63 1,291.62 1,087.60 1,364.69 1,874.95 1,592.83
Table S1 page 78/159
40S ribosomal protein S12
RS12_HUMAN RPS12
14,497
99.50%
2
2
4
Moesin
MOES_HUMAN MSN
67,804
100.00%
49
60
875
TFAYTNHTVLPEALER VIFLENYR VLYPNDNFFEGK WLLLCNPGLAELIAEK YEYGIFNQK 18.90% LVEALCAEHQINLIK TALIHDGLAR 69.30% AKFYPEDVSEELIQDITQR ALELEQER ALTSELANAR ALTSELANARDESK AMLENEK AMLENEKK APDFVFYAPR AQMVQEDLEK AQQELEEQTR AQQELEEQTRR EALLQASR EDAVLEYLK EGILNDDIYCPPETAVLLASYAVQSK
EKEELMER ESEAVEWQQK ESPLLFK EVWFFGLQYQDTK FVIKPIDK FYPEDVSEELIQDITQR GFSTWLK GMLREDAVLEYLK IAQDLEMYGVNYFSIK IGFPWSEIR ILALCMGNHELYMR ISQLEMAR KAPDFVFYAPR KAQQELEEQTR KESPLLFK KPDTIEVQQMK KTANDMIHAENMR KTQEQLALEMAELTAR KVTAQDVR LFFLQVK LKQIEEQTK LNKDQWEER NISFNDKK QEAEEAKEALLQASR QIEEQTK QLFDQVVK QRIDEFESM RALELEQER RKPDTIEVQQMK SGYLAGDK TAMSTPHVAEPAENEQDEQDENGAEASADLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
44.5 50.2 55.6 48.8 35.8 35.8 30.0 30.5 53.2 81.8 83.4 36.3 42.0 80.6 64.3 66.8 38.5 68.0 41.3 36.2 33.2 53.0 30.4 72.8 41.1 96.5 37.8 45.5 102.0 68.8 40.7 64.0 47.6 79.5 42.6 64.0 61.2 113.0 39.5 42.2 31.0 58.2 31.2 80.9 39.4 58.8 54.3 46.7 51.6 45.3 95.4
22.1 21.6 21.8 19.2 22.1 18.4 20.5 21.4 23.3 22.9 23.0 22.5 23.6 21.7 21.6 22.4 22.6 23.7 23.2 21.6 21.6 20.5 20.7 22.1 17.2 22.3 21.2 21.3 22.4 23.4 21.7 23.4 22.3 22.5 17.6 23.1 20.1 21.5 22.5 18.9 22.3 22.2 22.7 22.7 23.5 21.4 18.1 22.7 22.3 23.4 14.3
0 5 3 2 1 0 0 0 22 34 6 3 1 84 41 6 0 10 7 0 2 8 1 8 6 37 4 2 60 121 2 18 25 9 17 5 5 18 1 11 3 8 2 4 1 19 10 9 12 9 0
2 0 0 0 0 2 2 5 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 17 0 7 0 0 0 0 2 10 0 0 6 18 0 0 0 1 0 4 0 0 0 0 33 0 21
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,861.94 1,053.57 1,442.70 1,840.00 1,161.56 1,750.95 1,066.60 2,281.14 987.51 1,045.56 1,504.76 850.40 962.50 1,182.59 1,206.57 1,231.59 1,387.69 887.50 1,079.56 2,866.42 1,079.50 1,233.58 833.48 1,660.80 959.59 2,082.00 838.45 1,552.80 1,906.93 1,104.58 1,752.82 963.49 1,310.69 1,359.69 961.57 1,316.69 1,546.71 1,831.96 916.52 894.55 1,116.63 1,217.59 965.51 1,672.85 875.45 976.55 1,170.51 1,143.61 1,488.78 810.40 3,328.42
Table S1 page 79/159
Splicing factor 3B subunit 3
SF3B3_HUMAN SF3B3
135,561
100.00%
7
7
35
7.97%
Nucleoporin Nup37
NUP37_HUMAN NUP37
36,689
99.50%
2
2
3
8.28%
Ig lambda chain C regions
LAC_HUMAN IGLC1
11,218
100.00%
3
3
9
41.90%
Protein Daple
DAPLE_HUMAN CCDC88C
228,201
99.50%
2
2
2
0.84%
Lamina-associated polypeptide 2, isoform alpha
LAP2A_HUMAN TMPO
75,476
100.00%
3
3
8
5.91%
Bile salt-activated lipase
CEL_HUMAN CEL
79,304
100.00%
4
4
16
7.84%
LIM and SH3 domain protein 1
LASP1_HUMAN LASP1
29,699
100.00%
4
5
18
20.30%
Protocadherin Fat 2
FAT2_HUMAN FAT2
479,291
100.00%
10
10
33
3.04%
Elongation factor 1-alpha 1
EF1A1_HUMAN EEF1A1
50,123
100.00%
12
13
134
27.90%
TANDMIHAENMR TQEQLALEMAELTAR VLEQHK VTAQDVR VTTMDAELEFAIQPNTTGK DYIVVGSDSGR FLAVGLVDNTVR IVILEYQPSK LGAVFNQVAFPLQYTPR LPPNTNDEVDEDPTGNK TPVEEVPAAIAPFQGR TVLDPVTGDLSDTR VDGIAWSPETR VGAVAGNDWLIWDITR AAPSVTLFPPSSEELQANK AGVETTTPSK YAASSYLSLTPEQWK KAELEER NADLSDASRK PEFLEDPSVLTK SSTPLPTISSSAENTR YGVNPGPIVGTTR AISQSGVALSPWVIQK LGLLGDSVDIFK VGCPVGDAAR VGPLGFLSTGDANLPGNYGLR GFSVVADTPELQR LKQQSELQSQVR MGPSGGEGMEPERR QSFTMVADTPENLR ATDSGQPPLSASVR AVAAQDPVIYSLVR DVIEINPVTGVVK GSVVENSEPGELVATLK IDPYLGDISLK IILTDENDNPPQFK TGVLTVTGPLDYESK VPQDTVPGVELLR VQAIDPDSR VSIEDVNDNPPK EHALLAYTLGVK EVSTYIK IGGIGTVPVGR KLEDGPK LPLQDVYK QLIVGVNK QTVAVGVIK STTTGHLIYK THINIVVIGHVDSGK VETGVLKPGMVVTFAPVNVTTEVK
YEEIVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
82.1 122.0 34.7 35.1 106.0 38.6 64.4 39.3 74.4 79.4 80.3 96.9 56.4 42.3 47.4 59.7 74.6 36.5 33.3 42.9 64.6 45.5 71.9 76.7 39.5 83.0 64.3 43.2 27.3 81.8 41.3 87.4 51.5 60.2 33.0 54.3 62.0 53.2 30.9 59.4 59.2 30.0 84.2 30.0 48.0 45.9 33.2 38.5 48.2 43.5 30.9
19.2 22.8 19.1 24.3 22.4 22.0 20.3 19.1 20.2 19.3 21.9 22.8 22.8 21.7 21.4 23.3 21.4 24.4 23.4 23.2 23.1 22.5 19.2 20.0 21.6 21.6 23.4 22.1 16.3 23.2 22.3 20.3 16.9 21.8 22.0 23.1 22.3 19.1 20.6 23.0 20.5 21.6 16.1 19.8 21.1 17.1 19.4 21.3 20.0 16.0 20.6
21 29 2 6 27 1 3 1 4 6 11 9 2 1 1 4 4 1 1 2 4 2 4 6 2 4 4 2 0 6 2 6 2 2 1 2 4 8 1 5 7 1 37 1 11 2 1 5 0 0 1
3 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 12 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,402.62 1,703.86 753.43 788.43 2,082.01 1,167.56 1,303.74 1,189.68 1,921.03 1,854.84 1,681.89 1,488.75 1,230.61 1,785.93 1,986.02 990.51 1,743.86 874.46 1,076.53 1,374.72 1,647.82 1,330.71 1,683.94 1,276.72 1,001.48 2,118.10 1,418.73 1,443.79 1,521.64 1,608.77 1,385.70 1,501.84 1,382.79 1,728.90 1,233.67 1,643.83 1,579.82 1,422.80 1,000.51 1,326.65 1,314.74 839.45 1,025.61 786.44 975.55 870.54 914.57 1,120.60 1,588.88 2,531.38 780.41
Table S1 page 80/159
PGTB2_HUMAN RABGGTB
36,907
99.50%
2
2
2
PSMD6_HUMAN PSMD6
45,515
100.00%
6
6
10
Protein disulfide-isomerase A4
PDIA4_HUMAN PDIA4
72,916
100.00%
28
32
291
Macrophage-capping protein
CAPG_HUMAN CAPG
38,500
100.00%
8
8
31
Laminin subunit alpha-5
LAMA5_HUMAN LAMA5
399,769
100.00%
57
61
662
Geranylgeranyl transferase type-2 subunit beta 26S proteasome non-ATPase regulatory subunit 6
YYVTIIDAPGHR 6.65% HADYIASYGSK SDAPDTLLLEK 15.20% ANEDELK IDKVNEIVETNRPDSK IGLFYMDNDLITR PLENLEEEGLPK RLDEELEDAEK VNEIVETNRPDSK 42.20% DKDPPIPVAK DLGLSESGEDVNAAILDESGK DLGLSESGEDVNAAILDESGKK EFVTAFK EKYGIVDYMIEQSGPPSK EVSQPDWTPPPEVTLVLTK FAMEPEEFDSDTLR FDVSGYPTIK FEGGDRDLEHLSK FIEEHATK GESDPAYQQYQDAANNLR GQAVDYEGSR IDATSASVLASR KGQAVDYEGSR MDATANDVPSDR RFDVSGYPTIK RSPPIPLAK SHMMDVQGSTQDSAIK SHMMDVQGSTQDSAIKDFVLK TFDSIVMDPK TQEEIVAK VDATAETDLAK VDATAETDLAKR VEGFPTIYFAPSGDK VEGFPTIYFAPSGDKK VSQGQLVVMQPEK YALPLVGHR YGIVDYMIEQSGPPSK 32.80% AQVEIVTDGEEPAEMIQVLGPKPALK DLALAIR EGNPEEDLTADK EVQGNESDLFMSYFPR MQYAPNTQVEILPQGR QAALQVAEGFISR VSDATGQMNLTK YQEGGVESAFHK 18.70% AGALLPAIHEQLR AHPASNAIDGTER AIEASNAYSR AIQVFLLGGSR ASPDGLCQVSLQQGR AVAAEAQDTATR
95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
64.3 30.2 38.9 30.4 20.4 70.7 56.0 52.3 27.6 41.0 114.0 123.0 33.3 42.1 57.7 70.8 67.2 37.6 51.4 113.0 59.1 112.0 83.8 83.3 44.3 41.0 41.5 38.7 60.4 40.7 67.7 72.4 56.8 57.5 80.7 51.0 98.9 38.5 48.8 64.1 70.8 76.6 86.5 66.4 60.2 45.1 43.7 72.8 76.4 94.6 119.0
22.8 20.9 22.3 20.5 21.0 22.3 22.0 22.7 22.9 20.0 22.2 21.5 21.5 21.8 20.3 17.2 22.1 21.7 22.7 19.2 20.8 22.5 22.9 17.9 21.7 9.0 20.8 21.5 22.1 23.6 22.9 24.2 22.1 22.3 22.4 18.1 22.3 19.6 20.0 19.2 20.9 22.6 22.5 22.4 21.6 19.2 22.6 22.0 18.1 22.0 23.6
16 1 1 2 0 2 2 2 0 4 2 2 1 0 16 18 27 2 4 10 6 24 5 46 4 1 2 0 18 5 14 7 5 2 24 4 13 0 4 2 5 4 6 4 3 6 4 31 18 5 63
26 0 0 0 0 0 0 0 1 0 0 7 0 3 0 0 0 0 0 0 0 0 7 0 1 0 0 5 0 0 0 2 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,404.73 1,211.57 1,201.63 818.39 1,856.97 1,586.79 1,367.71 1,346.64 1,500.77 1,079.61 2,119.00 2,247.10 841.45 2,041.00 2,136.12 1,702.73 1,126.58 1,502.72 974.49 2,039.91 1,081.49 1,190.64 1,209.59 1,307.55 1,282.68 978.61 1,766.77 2,369.11 1,152.56 917.49 1,133.57 1,289.67 1,627.80 1,755.90 1,458.76 1,025.59 1,783.86 2,778.46 771.47 1,317.58 1,918.86 1,844.93 1,389.75 1,280.62 1,351.63 1,388.80 1,338.64 1,081.53 1,160.68 1,615.79 1,203.60
Table S1 page 81/159
AVPLQPPPPLTSASK CDQCSLGTFSLDAANPK CNCPPGLSGER DLADLAAYTALK DLGAPQAAAEAELAAAQR DQASQLLAGTEATLGHAK DTLASVFR EAQELNSR ECAPGYWGLPEQGCR ENVQGPK FANSPRPDLWVLER FPKPPQPIILR FYLQGPEPEPGQGTEDR GALDQLCGAGGLCR GAMSVSGR GDSCQECAPGFYR GFGEPFVLNPGTWALR GPPPELQPQPEGPPR GQDLGQAVLDAGHSVSTLEK GQLQLVEGNFR GQYCDICTAANSNK GYAQMAPVQPR HETAQQLEVLEQQSTSLGQDAR IAASATCGEEAPAR ILLVTDGAR ISFDSQISTTK LAASLDGAR LAQHEAGLMDLR LEEALQR LELEEAATPEGHAVR LGLVWAALQGAR LLWEMR LTAEQAR LVGGPVAGGDPNQTIR MQTFSPAGSK QATGDYMGVSLR QEVGVAVHTPQR QMIQETK STGDPWLTDGSYLDGTGFAR TLAEVER TLLAAIR TPLLQR TYQPWQFFASSK VQEQLSSLWEENQALATQTR VQSQLQAMQENVER VSLQLLR VSSYGGTLR WQGQYEGLR WWQSPPLSR YALVVEYANEDAR YELHSETQR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0%
42.8 70.9 35.7 80.4 115.0 106.0 49.4 53.6 56.2 33.3 30.8 33.8 92.6 90.9 52.3 34.7 40.1 81.6 104.0 81.8 98.4 61.1 36.8 90.3 41.4 66.4 58.0 34.7 30.2 83.6 78.4 38.7 44.6 78.7 43.4 51.8 32.8 36.2 132.0 39.5 38.8 44.8 57.2 98.7 110.0 45.7 46.4 38.7 30.3 36.7 34.4
18.0 19.5 17.0 21.8 22.2 21.4 21.9 21.8 18.6 20.8 21.2 10.8 20.8 20.7 22.3 10.4 22.3 22.1 22.1 23.5 16.4 22.9 21.4 21.6 20.0 22.2 24.0 22.2 22.9 22.4 17.8 24.3 24.3 21.4 22.3 22.2 22.4 23.8 20.9 24.1 21.8 19.0 22.5 21.6 22.7 21.8 21.1 22.6 21.9 22.3 21.9
2 2 2 17 24 12 22 9 2 2 0 0 13 11 2 2 1 29 11 22 2 10 0 4 3 13 13 0 1 14 52 2 6 23 2 8 3 3 10 4 10 13 5 7 37 14 11 4 1 1 0
0 0 0 0 0 2 0 0 0 0 4 4 0 0 0 0 0 0 31 0 0 0 2 0 0 0 0 4 0 25 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,502.86 1,883.83 1,246.53 1,264.68 1,752.89 1,810.93 908.48 946.46 1,779.76 771.40 1,699.89 1,305.81 1,919.88 1,447.68 764.37 1,546.61 1,760.91 1,595.82 2,025.03 1,260.67 1,601.67 1,217.61 2,468.20 1,403.66 957.57 1,226.63 873.48 1,353.70 858.47 1,621.82 1,254.73 847.45 788.43 1,550.83 1,053.50 1,297.62 1,320.70 877.45 2,115.96 817.44 757.49 727.45 1,489.71 2,331.16 1,659.81 828.53 939.49 1,136.55 1,156.59 1,512.73 1,162.55
Table S1 page 82/159
Metalloproteinase inhibitor 1
TIMP1_HUMAN TIMP1
23,153
100.00%
5
7
431
D-tyrosyl-tRNA(Tyr) deacylase 1
DTD1_HUMAN DTD1
23,406
100.00%
3
3
6
15,146
100.00%
3
3
10
Fatty acid-binding protein, epidermal FABP5_HUMAN FABP5
Lysyl-tRNA synthetase
SYK_HUMAN KARS
68,032
100.00%
8
8
13
Pre-mRNA-splicing factor SPF27
SPF27_HUMAN BCAS2
26,113
99.50%
2
2
6
Ezrin
EZRI_HUMAN EZR
69,397
100.00%
29
36
330
32.40% EPGLCTWQSLR FVYTPAMESVCGYFHR GFQALGDAADIR LQSGTHCLWTDQLLQGSEK SEEFLIAGK 14.80% ASVTVGGEQISAIGR SASSGAEGDVSSER SASSGAEGDVSSEREP 23.70% ELGVGIALR FEETTADGR LVVECVMNNVTCTR 11.70% INMVEELEK LIFYDLR LPETNLFETEETR LPETNLFETEETRK LQVMANSR MLVVGGIDR VAMFLTDSNNIK YLDLILNDFVR 10.70% TIVQLENEIYQIK YELPAPSSGQK 53.90% AKEAQDDLVK AKEELER ALQLEEER APDFVFYAPR AQEEAERLEADR DNAMLEYLK EAQDDLVK EKEELMLR ELSEQIQR ENPLQFK FVIKPIDK FYPEDVAEELIQDITQK GFPTWLK GMLKDNAMLEYLK IALLEEAR IAQDLEMYGINYFEIK IGFPWSEIR ILQLCMGNHELYMR IQVWHAEHR ITEAEKNER KAPDFVFYAPR KENPLQFK KPDTIEVQQMK KVSAQEVR LFFLQVK NISFNDKK QAVDQIK QLFDQVVK QLLTLSSELSQAR QQLETEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
38.2 97.1 106.0 133.0 65.6 36.6 36.7 53.7 37.2 52.5 71.1 32.4 38.7 72.5 44.3 35.8 31.4 40.9 45.6 56.3 29.5 57.1 40.5 45.8 80.6 42.2 47.8 42.5 32.8 49.8 35.5 41.1 82.5 30.7 65.8 56.8 79.9 68.8 45.8 33.2 51.7 47.6 31.1 64.0 51.1 42.2 31.2 48.6 58.8 113.0 40.8
22.8 20.1 23.5 21.9 21.7 21.9 18.8 17.9 17.1 19.8 22.3 24.2 19.0 22.6 23.1 23.3 23.7 23.3 20.8 20.3 22.7 24.0 24.4 21.6 21.7 21.3 22.9 22.2 23.9 22.9 24.5 17.2 22.0 23.9 22.3 18.6 22.0 23.4 21.6 23.1 23.5 22.3 21.9 23.1 22.5 18.9 22.7 21.7 21.4 21.4 23.5
6 18 259 9 100 1 1 4 2 4 4 1 1 2 0 1 2 2 2 2 0 5 4 17 84 12 15 1 1 10 1 6 5 1 5 34 25 121 2 1 3 25 1 5 4 11 2 7 19 45 6
0 1 0 38 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 4 0 0 0 0 6 0 0 0 0 0 0 5 0 4 0 0 0 1 0 2 2 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,346.65 1,963.88 1,233.62 2,201.07 993.53 1,444.78 1,338.58 1,564.67 927.56 1,025.45 1,694.80 1,104.56 939.53 1,578.77 1,706.86 934.48 975.53 1,368.68 1,380.75 1,590.87 1,176.59 1,116.59 874.46 987.51 1,182.59 1,416.67 1,096.54 917.46 1,063.55 1,002.52 875.46 959.59 2,038.00 848.47 1,525.78 914.53 1,962.95 1,104.58 1,809.85 1,175.61 1,089.55 1,310.69 1,003.56 1,316.69 916.52 894.55 965.51 801.45 976.55 1,445.80 875.45
Table S1 page 83/159
Thioredoxin-dependent peroxide reductase, mitochondrial
PRDX3_HUMAN PRDX3
27,675
100.00%
4
4
22
Latent-transforming growth factor beta-binding protein 3
LTBP3_HUMAN LTBP3
139,337
100.00%
5
6
18
Annexin A1
QQLETEKK QRIDEFEAL RKPDTIEVQQMK SGYLSSER SQEQLAAELAEYTAK THNDIIHNENMR VSAQEVR VSAQEVRK VTTMDAELEFAIQPNTTGK 18.40% DYGVLLEGSGLALR GLFIIDPNGVIK GTAVVNGEFK HLSVNDLPVGR 6.52% CTCAQGYAPAPDGR FCQVPAGGAGGGTGGSGPGLSR
ANXA1_HUMAN ANXA1
38,698
100.00%
18
25
353
GAGGGGALAR GYTQDNNIVNYGIPAHR TGALSTGALPPLAPEGDSVASK 58.10% AAYLQETGKPLDETLK AAYLQETGKPLDETLKK ALYEAGER CATSKPAFFAEK DITSDTSGDFR GDRSEDFGVNEDLADSDAR GGPGSAVSPYPTFNPSSDVAALHK
Bifunctional purine biosynthesis protein PURH
PUR9_HUMAN ATIC
64,599
100.00%
6
6
10
16.40%
Reticulocalbin-1
RCN1_HUMAN RCN1
38,873
100.00%
4
4
11
12.10%
Caveolin-1
CAV1_HUMAN CAV1
20,454
100.00%
2
2
2
19.70%
Nucleoside diphosphate kinase B
NDKB_HUMAN NME2
17,280
100.00%
11
14
74
73.70%
GLGTDEDTLIEILASR GTDVNVFNTILTTR GVDEATIIDILTK GVDEATIIDILTKR KGTDVNVFNTILTTR MYGISLCQAILDETKGDYEK NALLSLAK QAWFIENEEQEYVQTVK SEDFGVNEDLADSDAR SEIDMNDIK TPAQFDADELR AEISNAIDQYVTGTIGEDEDLIK ALFEEVPELLTEAEKK APGQLALFSVSDK DVSELTGFPEMLGGR EVSDGIIAPGYEEEALTILSK SLFSNVVTK AADLNGDLTATR IDNDGDGFVTTEELK TFDQLTPDESK TFDQLTPDESKER IDFEDVIAEPEGTHSFDGIWK YVDSEGHLYTVPIR ASEEHLK DRPFFPGLVK EISLWFKPEELVDYK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
33.7 43.5 51.6 61.3 125.0 55.5 40.3 36.8 106.0 103.0 58.5 35.2 55.4 59.6 106.0 55.8 32.0 65.9 65.7 68.1 55.8 48.4 82.2 95.4 67.4 122.0 102.0 98.1 52.0 114.0 32.8 40.7 98.3 122.0 48.6 88.1 80.7 40.5 72.3 36.8 90.1 31.0 81.2 114.0 34.6 57.9 62.7 30.5 48.6 38.5 44.1
22.9 23.6 22.3 20.5 22.5 21.5 24.7 22.5 22.4 22.0 18.3 22.6 21.9 15.2 21.6 19.0 22.8 21.2 21.4 18.2 22.5 21.0 19.3 17.8 22.1 21.8 21.8 20.9 19.1 20.3 20.6 20.9 22.2 18.0 21.3 22.1 21.9 20.9 22.3 21.8 20.9 19.5 23.0 22.6 22.1 22.7 21.4 23.5 20.3 20.6 21.1
1 5 12 17 68 3 4 2 27 10 8 1 3 2 1 2 0 9 2 4 8 4 21 2 3 54 40 69 3 9 0 3 25 9 11 30 1 2 2 2 2 1 2 4 1 4 1 0 5 3 3
0 0 33 0 5 2 0 0 0 0 0 0 0 0 1 0 3 0 1 9 0 2 0 9 29 2 0 0 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2
1,003.54 1,120.56 1,488.78 898.43 1,651.82 1,509.69 788.43 916.52 2,082.01 1,462.79 1,285.75 1,021.53 1,206.66 1,523.64 1,946.91 786.42 1,931.94 2,039.07 1,776.94 1,905.03 908.45 1,356.66 1,213.53 2,067.89 2,356.16 1,702.89 1,550.82 1,387.77 1,543.87 1,678.91 2,350.10 829.51 2,141.02 1,739.74 1,064.49 1,262.60 2,494.22 1,845.99 1,332.72 1,623.77 2,234.14 994.56 1,217.61 1,652.77 1,280.60 1,565.75 2,405.13 1,648.83 813.41 1,175.66 1,895.98
Table S1 page 84/159
28 kDa heat- and acid-stable phosphoprotein
HAP28_HUMAN PDAP1
20,613
100.00%
4
4
10
22.10%
Septin-11
SEP11_HUMAN SEPT11
49,381
100.00%
4
5
7
14.70%
Protein S100-A11
S10AB_HUMAN S100A11
11,723
100.00%
7
8
100
56.20%
Carbonyl reductase [NADPH] 1
CBR1_HUMAN CBR1
30,357
100.00%
10
11
70
53.80%
GDFCIQVGR GLVGEIIK GLVGEIIKR NIIHGSDSVK SAEKEISLWFKPEELVDYK TFIAIKPDGVQR VMLGETNPADSKPGTIR YMNSGPVVAMVWEGLNVVK GVEGLIDIENPNR KVTQLDLDGPK QYTSPEEIDAQLQAEK VTQLDLDGPK AAAQLLQSQAQQSGAQQTK FESDPATHNEPGVR STLMDTLFNTK SYELQESNVR VNIIPIIAK CIESLIAVFQK DGYNYTLSK DPGVLDR ISSPTETER NQKDPGVLDR TEFLSFMNTELAAFTK YAGKDGYNYTLSK DVCTELLPLIKPQGR EGWPSSAYGVTK EYGGLDVLVNNAGIAFK FHQLDIDDLQSIR GIGLAIVR GQAAVQQLQAEGLSPR ILLNACCPGWVR SETITEEELVGLMNK SPEEGAETPVYLALLPPDAEGPHGQFVSEK
Lysosomal Pro-X carboxypeptidase
PCP_HUMAN
PRCP
55,783
99.50%
2
2
7
Ras-related protein R-Ras
RRAS_HUMAN RRAS
23,463
100.00%
3
3
7
Heat shock protein HSP 90-beta
HS90B_HUMAN HSP90AB1
83,249
100.00%
38
49
810
VVNVSSIMSVR 5.24% NALDPMSVLLAR YYGESLPFGDNSFK 16.10% ADLESQR LDILDTAGQEEFGAMR LNVDEAFEQLVR 46.00% ADHGEPIGR ADLINNLGTIAK ALLFIPR APFDLFENK DNSTMGYMMAK EDQTEYLEER EGLELPEDEEEK EGLELPEDEEEKK EKYIDQEELNK ELISNASDALDK ELISNASDALDKIR ELKIDIIPNPQER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
51.1 36.3 52.3 40.6 31.4 34.9 88.7 118.0 72.9 49.5 98.7 41.8 135.0 65.3 35.8 44.9 39.9 70.9 54.8 45.5 34.5 39.7 104.0 51.9 62.0 58.1 74.9 40.5 48.8 96.8 58.2 106.0 84.2 87.9 58.2 52.9 38.6 79.5 114.0 35.9 74.8 51.5 37.6 55.5 49.1 58.8 43.1 55.1 92.5 108.0 37.3
22.8 16.7 16.7 21.7 20.7 19.8 22.3 22.3 22.6 21.3 22.0 21.8 21.5 21.7 22.0 21.0 9.5 21.2 20.7 20.5 22.4 21.6 22.4 22.5 19.1 21.4 21.3 21.8 14.8 21.8 22.9 22.0 20.3 22.4 21.1 20.8 23.3 22.1 23.0 22.0 20.9 17.1 22.7 11.8 18.8 20.1 20.8 23.3 23.1 21.4 18.5
4 2 5 1 0 2 4 19 2 2 4 2 2 1 1 1 6 6 6 2 2 0 79 2 1 5 6 0 5 8 4 9 0 8 5 2 1 3 3 3 86 11 4 6 12 3 2 4 15 10 2
0 0 0 0 2 0 8 12 0 0 0 0 2 0 0 0 0 0 0 0 0 2 1 0 0 0 0 10 0 4 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0
0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,051.50 828.52 984.62 1,069.56 2,311.19 1,344.76 1,785.92 2,125.05 1,425.73 1,213.68 1,849.88 1,085.58 1,957.01 1,555.71 1,286.63 1,224.59 980.65 1,307.70 1,060.50 771.40 1,019.50 1,141.60 1,849.90 1,479.71 1,738.95 1,281.61 1,779.93 1,599.81 798.52 1,652.87 1,458.74 1,692.84 3,164.54 1,206.65 1,299.71 1,623.73 818.40 1,765.84 1,432.74 951.47 1,242.71 829.53 1,080.54 1,280.50 1,311.57 1,416.64 1,544.73 1,408.70 1,275.64 1,544.83 1,564.87
Table S1 page 85/159
Polypeptide Nacetylgalactosaminyltransferase 12
GLT12_HUMAN GALNT12
66,921
100.00%
3
3
4
60 kDa heat shock protein, mitochondrial
CH60_HUMAN HSPD1
61,038
100.00%
11
14
57
EMLQQSK EQVANSAFVER GVVDSEDLPLNISR HFSVEGQLEFR HLEINPDHPIVETLR HNDDEQYAWESSAGGSFTVR HSQFIGYPITLYLEK IDIIPNPQER IEDVGSDEEDDSGK IEDVGSDEEDDSGKDK IRYESLTDPSK KHLEINPDHPIVETLR LGIHEDSTNR LSELLR NPDDITQEEYGEFYK RAPFDLFENK SIYYITGESK SLTNDWEDHLAVK SLVSVTK TLTLVDTGIGMTK VILHLK VILHLKEDQTEYLEER YESLTDPSK YESLTDPSKLDSGK YHTSQSGDEMTSLSEYVSR YIDQEELNK 5.16% ESSDSFVPLLR LANELSGLPK LQLQGEELR 25.10% ALMLQGVDLLADAVAVTMGPK APGFGDNRK GYISPYFINTSK ISSIQSIVPALEIANAHR KISSIQSIVPALEIANAHR LSDGVAVLK LVQDVANNTNEEAGDGTTTATVLAR
High mobility group protein B1
HMGB1_HUMAN HMGB1
24,877
100.00%
9
16
121
TLNDELEIIEGMK TVIIEQSWGSPK VGEVIVTKDDAMLLK VTDALNATR 40.50% FKDPNAPK GEHPGLSIGDVAK GEHPGLSIGDVAKK HPDASVNFSEFSK IKGEHPGLSIGDVAK KHPDASVNFSEFSK LGEMWNNTAADDKQPYEK MSSYAFFVQTCR TYIPPK TYIPPKGETK YEKDIAAYR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
50.8 76.7 113.0 64.6 69.1 133.0 73.6 57.1 62.6 32.8 47.5 30.3 53.3 44.8 91.9 49.7 54.9 83.6 43.2 109.0 35.5 69.3 43.0 67.9 75.7 60.6 33.7 35.1 45.2 73.6 34.4 68.3 60.0 26.8 48.1 139.0 72.3 69.6 31.0 58.2 42.0 45.4 47.6 52.8 62.7 40.2 76.8 104.0 39.9 35.2 50.4
23.4 23.5 22.4 23.7 21.0 17.3 21.8 21.4 15.1 17.3 22.3 18.4 22.5 23.2 17.8 22.6 23.7 21.8 18.8 22.1 7.8 22.0 23.0 22.6 17.9 23.1 23.1 17.5 21.6 20.9 24.4 23.4 17.7 14.6 20.6 21.8 23.3 22.1 20.2 24.0 23.5 22.8 21.1 21.1 19.7 23.1 20.8 19.7 22.7 21.6 22.0
6 18 54 7 2 7 5 13 1 0 2 0 9 17 21 6 6 97 2 57 7 7 9 14 3 21 1 1 2 2 1 4 2 0 1 4 8 4 0 8 9 2 0 3 14 2 7 19 1 2 5
0 0 0 4 8 54 9 0 0 2 0 0 13 0 0 0 0 7 0 0 0 102 0 3 45 0 0 0 0 14 0 0 4 1 0 3 0 0 1 0 0 0 1 2 30 15 15 0 0 2 2
0 0 0 0 1 0 0 0 0 0 0 11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 15 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
879.42 1,249.62 1,513.79 1,348.67 1,782.95 2,255.96 1,808.96 1,194.65 1,494.61 1,737.73 1,308.68 1,911.05 1,141.56 730.45 1,847.80 1,236.64 1,160.58 1,527.74 733.45 1,365.73 722.49 2,015.05 1,039.49 1,539.75 2,192.94 1,151.56 1,249.64 1,041.59 1,085.60 2,145.13 961.49 1,389.71 1,919.07 2,047.17 901.54 2,560.25 1,504.76 1,344.72 1,646.90 960.51 916.49 1,279.66 1,407.76 1,464.68 1,520.84 1,592.77 2,109.96 1,512.66 718.41 1,133.62 1,128.57
Table S1 page 86/159
Prostaglandin reductase 1
PTGR1_HUMAN PTGR1
35,853
100.00%
6
7
14
Ras GTPase-activating-like protein IQGAP1
IQGA1_HUMAN IQGAP1
189,241
100.00%
30
32
145
26.40% EYIIEGFENMPAAFMGMLK HFVGYPTNSDFELK LKEGDTMMGQQVAK TGPLPPGPPPEIVIYQELR TVESLEETLKK VVGAVGSDEK 24.60% ALESGDVNTVWK ALQSPALGLR ATFYGEQVDYYK EEIQSSISGVTAAYNR EQLWLANEGLITR FLSAIVSSVDK FQPGETLTEILETPATSEQEAEHQR
GLQQQNSDWYLK IFYPETTDIYDR IFYPETTDIYDRK IIGNLLYYR ILAIGLINEALDEGDAQK ITLQDVVSHSK LAAVALINAAIQK LEGVLAEVAQHYQDTLIR LGLAPQIQDLYGK LGNFFSPK LPYDVTPEQALAHEEVK LQQTYAALNSK LTAEEMDER NPNAMLVNLEEPLASTYQDILYQAK QSGQTDPLQKEELQSGVDAANSAAQQYQR
Glutathione S-transferase P
GSTP1_HUMAN GSTP1
23,339
100.00%
15
19
715
SNQQLENDLNLMDIK SWVNQMESQTGEASK TLINAEDPPMVVVR TLQALQIPAAK VDFTEEEINNMK VDQIQEIVTGNPTVIK YGIQMPAFSK YQELINDIAR 70.00% AFLASPEYVNLPINGNGK AFLASPEYVNLPINGNGKQ ALPGQLKPFETLLSQNQGGK ASCLYGQLPK DQQEAALVDMVNDGVEDLR EEVVTVETWQEGSLK FQDGDLTLYQSNTILR MLLADQGQSWK MLLADQGQSWKEEVVTVETWQEGSLK
MPPYTVVYFPVR PPYTVVYFPVR TLGLYGK TLGLYGKDQQEAALVDMVNDGVEDLR
YISLIYTNYEAGK YISLIYTNYEAGKDDYVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
58.6 41.9 39.0 59.2 40.7 40.1 75.9 54.2 68.1 100.0 94.1 42.3 51.2 31.2 50.3 27.3 61.9 118.0 38.2 76.0 78.1 47.5 44.0 54.1 51.7 70.4 44.6 97.1 87.4 109.0 61.0 72.2 59.5 78.1 47.8 36.5 90.3 86.5 84.9 57.3 129.0 102.0 141.0 67.4 50.8 76.9 73.2 41.0 75.3 55.5 121.0
21.0 22.0 22.2 18.1 21.7 23.7 23.1 16.1 20.0 22.1 21.2 20.8 20.3 22.8 22.4 22.9 20.0 19.9 21.4 13.2 19.6 20.3 21.8 21.5 22.4 18.8 20.6 20.6 22.6 18.9 20.7 15.3 20.0 18.7 21.8 23.7 21.6 21.6 18.5 22.5 21.8 23.2 21.8 23.1 21.6 22.1 21.2 21.1 21.3 22.7 22.1
2 2 2 4 0 1 6 3 4 3 6 1 0 1 2 0 4 16 0 4 4 4 5 0 4 5 0 0 2 2 8 6 6 4 4 3 4 3 29 10 78 81 136 14 0 4 119 27 0 4 84
0 0 2 0 1 0 0 0 0 0 0 0 9 0 0 1 0 9 2 0 3 0 0 6 0 0 4 4 0 0 0 0 0 0 0 0 4 0 73 0 9 0 0 0 4 0 0 0 22 0 10
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2
2,239.01 1,653.79 1,567.75 2,073.14 1,276.70 960.50 1,318.66 1,025.61 1,483.67 1,724.85 1,542.83 1,165.65 2,841.35 1,479.72 1,532.73 1,660.82 1,124.65 1,883.01 1,226.67 1,295.81 2,055.09 1,415.79 909.48 1,938.98 1,236.66 1,109.48 2,851.42 3,147.49 1,790.86 1,697.74 1,553.84 1,153.69 1,468.66 1,753.97 1,141.57 1,234.64 1,903.99 2,032.05 2,126.16 1,136.58 2,116.98 1,733.86 1,883.95 1,276.64 3,007.47 1,484.76 1,337.73 751.44 2,849.40 1,534.78 2,155.06
Table S1 page 87/159
Fibronectin
FINC_HUMAN FN1
262,581
100.00%
5
5
18
14-3-3 protein zeta/delta
1433Z_HUMAN YWHAZ
27,728
100.00%
21
27
754
3.31% ITYGETGGNSPVQEFTVPGSK LGVRPSQGGEAPR NLQPASEYTVSLVAIK SYTITGLQPGTDYK VPGTSTSATLTGLTR 73.90% DICNDVLSLLEK DNLTLWTSDTQGDEAEAGEGGEN
Agrin
AGRIN_HUMAN AGRN
214,820
100.00%
70
86
1629
DSTLIMQLLR EKIETELR EMQPTHPIR FLIPNASQAESK GIVDQSQQAYQEAFEISK GIVDQSQQAYQEAFEISKK KEMQPTHPIR KGIVDQSQQAYQEAFEISK LAEQAER LAEQAERYDDMAACMK MKGDYYR NELVQK NLLSVAYK NLLSVAYKNVVGAR SVTEQGAELSNEER TAFDEAIAELDTLSEESYK YDDMAACMK YLAEVAAGDDK YLAEVAAGDDKK 41.60% AAAVSSGFDGAIQLVSLGGR AIVDVHFDPTTAFR ALEPQGLLLYNGNAR ALGPAGCEADASAPATCAEMR ALQSNHFELSLR ASCYNSALGCCSDGK AYGTGFVGCLR AYHTLR CEFGAR CEHPPPGPVCGSDGVTYGSACELR
DDCEQMTGLCSCKPGVAGPK DFLALALLDGR DQCPEPCR EAACLQQTQIEEAR EPLYVGGAPDFSK EPVTLGAWTR ESLLDGGNK FDGPCDPCQGALPDPSR FDTGSGPAVLTSAVPVEPGQWHR
FGALCEAETGR FHCQCPPGR FNAVCLSR GAPEGTVCGSDGADYPGECQLLR
GDFVSLALR GIVTDGR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
58.0 44.8 49.4 45.4 80.8 82.6 129.0 79.3 47.8 67.1 62.7 134.0 74.9 43.9 115.0 59.4 50.3 42.7 31.1 51.4 79.1 112.0 114.0 59.2 47.0 79.5 106.0 56.0 36.1 119.0 66.7 109.0 64.2 37.0 35.5 38.6 41.4 49.9 35.0 105.0 63.3 30.0 38.5 50.9 93.8 87.4 29.5 72.7 123.0 62.2 33.1
21.7 21.1 20.4 21.8 21.6 23.7 13.8 21.3 22.3 22.4 23.7 21.8 22.5 22.5 22.5 21.6 16.1 19.2 22.9 19.1 17.7 20.7 20.6 10.0 22.5 22.7 21.1 22.2 21.0 17.2 22.1 10.4 21.2 24.2 18.8 16.2 14.5 21.5 11.5 21.8 22.7 23.4 23.5 16.6 20.8 20.8 18.0 23.2 16.3 21.4 24.0
2 0 1 2 5 60 14 113 5 13 21 169 6 0 3 36 0 6 2 49 4 64 34 21 8 53 109 5 0 7 6 4 16 6 1 0 0 3 4 11 16 1 1 2 5 35 0 32 10 24 2
0 8 0 0 0 0 0 0 0 0 0 8 7 11 4 0 2 0 0 0 2 0 10 0 0 29 0 1 2 4 6 0 0 0 0 1 4 0 0 0 0 0 0 0 101 0 2 0 3 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,168.05 1,323.71 1,732.95 1,543.76 1,461.79 1,418.72 2,409.00 1,189.66 1,017.56 1,108.56 1,304.69 2,040.99 2,169.08 1,252.65 2,169.08 816.42 1,933.81 932.43 730.41 907.53 1,503.86 1,548.71 2,131.99 1,104.42 1,151.56 1,279.65 1,875.99 1,588.81 1,628.88 2,105.91 1,414.74 1,649.64 1,200.58 760.41 739.32 2,602.11 2,225.93 1,203.67 1,061.41 1,646.78 1,379.68 1,129.60 932.47 1,888.80 2,408.20 1,210.55 1,158.49 966.48 2,409.05 977.54 717.39
Table S1 page 88/159
GKDFLALALLDGR GLYVAAQGACR GMLCGFGAVCEPNAEGPGR GPSGLLLYNGQK GSGVGECGDHPCLPNPCHGGAPCQNLEAGR
HQGPCDQAPSPCLGVQCAFGATCAVK
IFFVNPAPPYLWPAHK KFDGPCDPCQGALPDPSR KSPCPSVVAPVCGSDASTYSNECELQR
LALEFR LELGIGPGAATR LLDVNNQR LRDLGPGK MALEVVFLAR QAPVCGDDGVTYENDCVMGR QENVFK QIQVSR QLLTPEHVLR QVDVTSFAGHPCTR RLEFR SADGLTASCLCPATCR SAGDVDTLAFDGR SELFGETAR SFLAFPTLR SGCTPCSCDPQGAVR SIESTLDDLFR SPCPSVVAPVCGSDASTYSNECELQR
SPCQPNPCHGAAPCR SREPVTLGAWTR STVPVNTNR TDGKGDFVSLALR TEATQGLVLWSGK TFVEYLNAVTESEK TFVGAGLR TPSLDAEGSNCPATK TYDSDCWR VCGSDGVTYGNECQLK VGPTCADEK VGPTCADEKSPCQPNPCHGAAPCR
VLGAPVPAFEGR VLGESPVPHTVLNLK VLGESPVPHTVLNLKEPLYVGGAPDFSK
Ribosome-binding protein 1
RRBP1_HUMAN RRBP1
152,453
100.00%
4
4
11
Kinesin-1 heavy chain
KINH_HUMAN KIF5B
109,668
100.00%
4
4
8
VLPEGGAQCECPLGR VTCDGAYRPVCAQDGR VVISGFGDPLICDNQVSTGDTR 4.33% DALNQATSQVESK DAQDVQASQAEADQQQTR GNTPATGTTQGK VEPAVSSVVNSIQVLTSK 5.30% ISFLENNLEQLTK LITDLQDQNQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
103.0 69.6 94.2 57.2 35.9 55.0 29.5 34.3 57.7 40.6 79.9 57.4 50.7 62.6 119.0 33.2 31.6 43.5 69.8 33.2 89.9 115.0 57.2 58.0 82.9 70.9 67.8 63.2 51.4 53.1 76.5 103.0 124.0 55.5 97.3 49.4 106.0 51.0 70.6 69.0 71.0 60.9 81.1 37.7 108.0 72.8 139.0 38.5 61.8 54.2 45.7
19.9 23.5 17.4 22.0 14.5 18.8 20.1 19.3 18.6 21.6 20.2 20.9 18.1 20.4 14.8 24.0 24.0 15.2 21.1 21.3 18.9 21.5 22.2 20.3 13.6 22.0 17.1 17.1 22.5 22.4 22.2 22.3 22.4 23.1 20.8 13.4 18.4 19.4 15.6 21.0 16.3 18.0 21.6 20.0 20.9 22.3 20.3 22.4 17.9 22.3 22.9
32 22 15 8 0 0 0 0 0 24 94 54 17 16 4 1 2 8 16 18 19 116 25 95 4 34 0 5 25 17 12 84 164 21 8 11 31 2 0 44 23 0 7 2 14 3 6 1 1 2 2
0 0 0 0 2 4 7 1 2 0 0 0 0 0 2 0 0 2 17 0 0 0 0 0 0 0 2 3 32 0 3 0 0 0 0 0 0 0 2 0 4 12 0 10 2 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,388.79 1,165.58 1,994.85 1,246.68 3,160.32 2,816.24 1,897.02 2,016.89 2,998.33 748.44 1,154.65 971.53 855.51 1,164.65 2,242.92 764.39 730.42 1,205.70 1,574.74 720.42 1,739.75 1,323.62 1,009.50 1,051.59 1,651.66 1,295.65 2,870.24 1,708.71 1,372.73 987.52 1,378.73 1,389.74 1,629.80 820.47 1,547.70 1,102.43 1,786.77 976.44 2,666.13 1,212.67 1,602.92 2,963.59 1,642.77 1,824.81 2,350.14 1,390.68 1,988.89 1,132.56 1,857.03 1,548.83 1,315.69
Table S1 page 89/159
Rab GDP dissociation inhibitor beta GDIB_HUMAN GDI2
50,648
100.00%
23
27
108
QAVEQQIQSHR SAEIDSDDTGGSAAQK 60.00% DLGTESQIFISR DWNVDLIPK EIRPALELLEPIEQK EPEKEIRPALELLEPIEQK FKIPGSPPESMGR FLMANGQLVK FVSISDLLVPK GRDWNVDLIPK IPGSPPESMGR LSAIYGGTYMLNKPIEEIIVQNGK
22,641
100.00%
3
3
4
16.80%
DNA-(apurinic or apyrimidinic site) APEX1_HUMAN APEX1 lyase
35,538
100.00%
12
14
96
47.20%
Calnexin
CALX_HUMAN CANX
67,552
100.00%
2
2
2
5.24%
High mobility group protein B3
HMGB3_HUMAN HMGB3
22,963
100.00%
6
6
21
29.50%
DnaJ homolog subfamily C member DNJC8_HUMAN DNAJC8 8 COF1_HUMAN CFL1 Cofilin-1
29,824
99.90%
2
2
6
10.70%
18,485
100.00%
9
11
172
66.30%
Prefoldin subunit 3
PFD3_HUMAN VBP1
LYSESLAR MLLYTEVTR MTGSEFDFEEMKR NPYYGGESASITPLEDLYK NPYYGGESASITPLEDLYKR NTNDANSCQIIIPQNQVNR QLICDPSYVK SPYLYPLYGLGELPQGFAR TDDYLDQPCYETINR TYDATTHFETTCDDIK VICILSHPIK VPSTEAEALASSLMGLFEK VTEGSFVYK KLDEQYQK NLDSLEEDLDFLR QPGNETADTVLK EAAGEGPALYEDPPDQK EGYSGVGLLSR GAVAEDGDELR GAVAEDGDELRTEPEAK ICSWNVDGLR LDYFLLSHSLLPALCDSK LPAELQELPGLSHQYWSAPSDK NAGFTPQER NDKEAAGEGPALYEDPPDQK QGFGELLQAVPLADSFR TSPSGKPATLK VSYGIGDEEHDQEGR APVPTGEVYFADSFDR KIPNPDFFEDLEPFR KLGEMWNNLNDSEK KNPEVPVNFAEFSK LGEMWNNLNDSEK LGEMWNNLNDSEKQPYITK MSAYAFFVQTCR STNPGISIGDVAK EGKPTIVEEDDPELFK QREEEIEAQEK AVLFCLSEDKK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
31.7 71.5 80.0 43.3 44.8 23.5 39.5 43.4 65.7 36.0 43.3 53.7 55.9 53.4 62.2 119.0 113.0 59.4 32.8 98.6 97.4 66.4 37.9 103.0 44.1 33.5 45.3 43.2 76.3 70.3 36.2 85.5 39.8 45.9 57.0 45.0 44.8 89.8 31.5 81.7 82.3 32.5 73.0 40.0 74.0 40.7 91.7 97.2 57.9 38.6 65.1
22.6 18.8 22.6 21.6 16.1 17.9 23.4 22.8 16.5 21.5 21.1 19.3 20.3 23.0 17.3 22.1 21.6 21.9 23.3 21.6 18.1 17.8 18.4 22.6 21.8 21.9 22.6 21.9 20.6 22.8 20.2 21.5 21.8 21.1 20.9 22.8 21.0 21.6 21.2 17.4 21.5 22.6 22.7 22.3 19.5 22.1 21.0 23.0 22.3 20.8 22.5
0 3 6 2 0 0 3 6 6 1 2 0 6 13 3 6 2 1 1 8 2 2 2 14 3 2 1 1 5 11 2 4 2 1 0 8 0 41 2 10 1 0 2 2 5 0 2 8 2 4 2
1 0 0 0 2 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 0 2 1 9 0 0 0 0 0 0 0 3 0 0 4 0 2 0 0 1 0 1 0 0 0 2 0 0 0 0 0
0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,323.68 1,551.68 1,365.70 1,099.58 1,778.01 2,261.24 1,418.71 1,136.61 1,217.71 1,312.70 1,143.55 2,667.41 938.49 1,125.60 1,622.68 2,117.01 2,273.11 2,199.06 1,222.61 2,141.11 1,902.82 1,917.82 1,179.69 1,980.00 1,029.53 1,051.54 1,578.77 1,272.64 1,786.81 1,137.59 1,131.53 1,786.85 1,219.59 2,092.08 2,466.23 1,019.49 2,143.98 1,847.97 1,086.62 1,690.73 1,770.83 1,863.93 1,677.79 1,605.83 1,565.69 2,280.10 1,496.67 1,258.66 1,845.91 1,388.67 1,309.68
Table S1 page 90/159
EILVGDVGQTVDDPYATFVK HELQANCYEEVKDR KEDLVFIFWAPESAPLK LGGSAVISLEGKPL MIYASSK MLPDKDCR NIILEEGKEILVGDVGQTVDDPYATFVK
WD repeat-containing protein 5
WDR5_HUMAN WDR5
36,571
100.00%
4
4
6
Eukaryotic translation initiation factor 3 subunit K
EIF3K_HUMAN EIF3K
25,042
100.00%
3
3
6
60S acidic ribosomal protein P2
RLA2_HUMAN RPLP2
11,647
100.00%
2
2
4
UV excision repair protein RAD23 homolog B
RD23B_HUMAN RAD23B
43,153
100.00%
3
5
11
Serglycin
SRGN_HUMAN SRGN
17,635
100.00%
3
3
11
Alpha-soluble NSF attachment protein
SNAA_HUMAN NAPA
33,216
100.00%
3
3
6
Zyxin
ZYX_HUMAN ZYX
61,258
100.00%
3
3
6
19,962
100.00%
5
5
13
YALYDATYETK 17.10% FSPNGEWLASSSADK TLIDDDNPPVSFVK TLPAHSDPVSAVHFNR YILAATLDNTLK 18.80% ENAYDLEANLAVLK WLLAEMLGDLSDSQLK YNPENLATLER 39.10% LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK NIEDVIAQGIGK 13.90% NQPQFQQMR QEKPAEKPAETPVATSPTATDSTSGDSSR
Anterior gradient protein 2 homolog AGR2_HUMAN AGR2
26S proteasome non-ATPase regulatory subunit 5
PSMD5_HUMAN PSMD5
56,179
100.00%
3
3
8
General vesicular transport factor p115 Epidermal growth factor receptor
USO1_HUMAN USO1
107,880
100.00%
2
2
4
EGFR_HUMAN EGFR
134,261
100.00%
7
9
36
Alpha-N-acetylglucosaminidase
ANAG_HUMAN NAGLU
82,150
100.00%
5
6
12
QIIQQNPSLLPALLQQIGR 20.90% CNPDSNSANCLEEK GPMFELLPGESNK IQDLNR 13.90% EAEAMALLAEAER NSQSFFSGLFGGSSK VAGYAALLEQYQK 7.52% FSPGAPGGSGSQPNQK GPPASSPAPAPK QHPVPPPAQNQNQVR 26.90% HLSPDGQYVPR IMFVDPSLTVR LPQTLSR LYAYEPADTALLLDNMK LYAYEPADTALLLDNMKK 10.70% IVENSDAVTEILNNAELLK TYLSEGPYYVKPVSTTAVEGAE VFTAIANQPWAQK 2.29% IVAFENAFER NDGVLLLQALTR 7.19% EISDGDVIISGNK GDSFTHTPPLDPQELDILK IICAQQCSGR IPLENLQIIR LTQLGTFEDHFLSLQR NLQEILHGAVR NYDLSFLK 10.20% AGGVLAYELLPALDEVLASDSR FLLGSWLEQAR LLLTSAPSLATSPAFR LPRPLPAVPGELTEATPNR YDLLDLTR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
113.0 58.2 79.6 91.4 37.6 33.2 107.0 72.4 76.9 77.7 38.3 69.5 38.8 80.8 56.2 33.5 77.3 33.0 64.8 97.4 74.7 57.5 30.3 77.4 115.0 66.1 53.9 39.3 57.2 38.7 56.0 35.4 94.2 75.9 96.4 50.4 85.0 36.3 61.5 43.2 45.7 42.7 64.8 46.2 53.7 47.5 51.0 53.8 65.7 32.8 31.2
21.6 21.4 19.5 18.0 20.3 20.8 19.1 22.2 21.3 23.2 22.5 20.0 23.0 22.4 22.7 20.0 22.2 22.0 20.9 11.1 13.4 22.9 22.6 22.3 22.4 21.9 21.4 23.3 21.2 22.2 22.3 20.8 22.5 22.5 19.9 21.6 22.0 22.1 19.3 23.9 21.6 21.8 14.3 22.2 20.1 20.9 19.7 22.1 17.9 17.0 21.4
10 0 7 61 1 1 0 8 2 2 0 1 2 2 2 0 2 2 0 5 4 6 1 2 2 2 1 1 0 2 4 2 4 1 4 2 2 2 2 5 2 2 9 2 2 4 2 4 3 0 1
0 13 11 0 0 0 57 0 0 0 1 0 0 0 0 2 0 0 2 1 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 9 0 0 1 0 0 1 0 0 1 0
0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,166.10 1,790.81 1,990.07 1,340.78 815.40 1,050.47 3,062.59 1,337.63 1,595.73 1,559.80 1,747.89 1,335.75 1,562.81 1,834.93 1,319.66 2,774.43 1,256.69 1,192.55 2,945.40 2,130.24 1,637.65 1,418.70 758.42 1,403.68 1,549.73 1,453.77 1,515.72 1,076.57 1,709.88 1,268.64 1,293.69 814.48 1,940.97 2,069.06 2,085.11 2,361.15 1,473.79 1,195.61 1,312.76 1,346.68 2,123.07 1,192.56 1,208.74 1,904.99 1,249.70 999.52 2,259.19 1,319.71 1,644.93 2,028.12 1,008.54
Table S1 page 91/159
PDZ and LIM domain protein 1
PDLI1_HUMAN PDLIM1
36,053
100.00%
11
12
28
48.60% CGTGIVGVFVK DFEQPLAISR ERVTPPEGYEVVTVFPK LVGGKDFEQPLAISR MNLASEPQEVLHIGSAHNR SAMPFTASPASSTTAR TAASGVEANSRPLDHAQPPSSLVIDKESEVYK
VAASIGNAQK VITNQYNNPAGLYSSENISNFNNALESK
Lysozyme C
LYSC_HUMAN LYZ
16,519
100.00%
2
2
9
Stress-induced-phosphoprotein 1
STIP1_HUMAN STIP1
62,624
100.00%
21
24
67
ADP-sugar pyrophosphatase
NUDT5_HUMAN NUDT5
24,310
100.00%
5
6
15
EH domain-containing protein 4
EHD4_HUMAN EHD4
61,160
100.00%
3
3
5
Carcinoembryonic antigen-related cell adhesion molecule 5
CEAM5_HUMAN CEACAM5
76,778
99.50%
2
2
12
Lamin-A/C
LMNA_HUMAN LMNA
74,123
100.00%
27
32
213
VTPPEGYEVVTVFPK VWSPLVTEEGKR 27.00% STDYGIFQINSR TPGAVNACHLSCSALLQDNIADAVACAK
40.70% AAALEFLNR ALSVGNIDDALQCYSEAIK AMADPEVQQIMSDPAMR AMDVYQK DPQALSEHLKNPVIAQK EAADGYQR EGLQNMEAR ELDPTNMTYITNQAAVYFEK ELGNDAYK ETKPEPMEEDLPENKK FMNPFNMPNLYQK HDSPEDVKR HEANNPQLK IGNSYFKEEK ILKEQER KAAALEFLNR LAYINPDLALEEK LDPHNHVLYSNR LMDVGLIAIR NPVIAQK TYEEGLKHEANNPQLK 23.30% EQTADGVAVIPVLQR HANAKPFEVPFLK KEQTADGVAVIPVLQR QYIISEELISEGK TTYMDPTGK 5.91% EYQISAGDFPEVK FGNAFLNR LFEAEAQDLFR 6.13% QIIGYVIGTQQATPGPAYSGR SDLVNEEATGQFR TLTLLSVTR 43.50% AAYEAELGDAR AAYEAELGDARK AGQVVTIWAAGAGATHSPPTDLVWK
AQHEDQVEQYKK EAALSTALSEKR IDSLSAQLSQLQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
58.0 43.0 39.9 74.2 35.2 91.2 22.4 63.2 51.0 43.6 57.6 86.2 58.8 59.5 110.0 95.9 33.4 39.4 38.0 44.3 82.4 33.8 38.1 33.2 36.3 41.6 56.4 38.5 29.9 70.5 38.3 70.8 45.0 52.6 89.5 33.4 85.6 59.6 35.3 35.1 40.3 50.0 102.0 68.5 64.0 59.7 39.3 53.4 46.5 57.5 84.6
22.7 23.6 21.5 20.9 22.2 22.2 20.3 22.5 21.0 21.0 21.9 21.3 20.6 23.5 21.8 17.9 19.5 19.2 20.9 19.3 20.5 21.8 21.6 21.0 22.6 23.2 22.5 23.4 20.6 22.5 22.4 20.8 17.2 22.0 19.5 20.5 16.9 22.6 18.6 22.6 22.3 21.8 20.1 21.5 13.2 22.3 23.2 19.5 21.8 22.0 20.7
2 3 0 2 0 5 0 3 0 3 2 6 0 2 2 2 1 0 2 5 4 1 1 1 0 2 2 2 0 12 2 10 2 2 2 0 3 3 1 2 1 2 4 8 25 2 2 0 0 6 15
0 0 1 2 0 0 0 0 2 0 0 0 3 0 0 0 0 2 0 0 0 0 3 0 2 0 0 0 1 0 0 0 0 2 0 2 4 0 0 0 0 0 0 0 0 0 0 2 5 0 0
0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,136.61 1,175.61 1,947.02 1,629.90 2,119.04 1,598.75 3,395.71 958.53 3,101.48 1,661.88 1,400.75 1,400.68 2,927.38 1,004.55 2,067.01 1,937.84 870.40 1,888.03 909.41 1,063.48 2,364.11 909.43 1,913.92 1,659.77 1,082.52 1,050.53 1,214.61 915.53 1,132.65 1,488.80 1,464.73 1,100.65 769.46 1,870.93 1,595.88 1,497.82 1,723.97 1,508.79 1,029.46 1,482.71 938.48 1,338.67 2,177.14 1,465.69 1,003.62 1,165.55 1,293.64 2,533.32 1,502.72 1,275.69 1,430.79
Table S1 page 92/159
62,066
100.00%
5
5
21
COP9 signalosome complex subunit CSN4_HUMAN COPS4 4
46,252
100.00%
3
3
6
VPS29_HUMAN VPS29
20,488
99.50%
2
3
5
CLH1_HUMAN CLTC
191,601
100.00%
32
35
130
N-acetylglucosamine-6-sulfatase
Vacuolar protein sorting-associated protein 29 Clathrin heavy chain 1
GNS_HUMAN GNS
IRIDSLSAQLSQLQK ITESEEVVSR KLESTESR LADALQELR LAVYIDR LEAALGEAK LKDLEALLNSK LLEGEEER LQEKEDLQELNDR LQTMKEELDFQK LRDLEDSLAR LSPSPTSQR MQQQLDEYQELLDIK NSNLVGAAHEELQQSR QNGDDPLLTYR SGAQASSTPLSPTR SNEDQSMGNWQIK TALINSTGEEVAMR TLEGELHDLR VAVEEVDEEGK VAVEEVDEEGKFVR 10.10% AFQNVFAPR IQEPNTFPAILR SDVLVEYQGEGR TPGVFDPGYR WQTLLSVDDLVEK 9.36% IASQMITEGR NAAQVLVGIPLETGQK VISFEEQVASIR 12.60% GDFDENLNYPEQK TLAGDVHIVR 24.30% ADDPSSYMEVVQAANTSGNWEELVK AFMTADLPNELIELLEK ALEHFTDLYDIKR AYEFAER DAMQYASESK ENPYYDSR FNALFAQGNYSEAAK GQCDLELINVCNENSLFK GQFSTDELVAEVEK HELIEFR IAAYLFK ISGETIFVTAPHEATAGIIGVNR IVLDNSVFSEHR IYIDSNNNPER KFNALFAQGNYSEAAK LAELEEFINGPNNAHIQQVGDR LASTLVHLGEYQAAVDGAR LEKHELIEFR LLLPWLEAR LLYNNVSNFGR
95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
40.4 90.0 59.2 76.1 30.2 37.0 60.2 39.2 87.4 44.9 32.6 36.3 105.0 101.0 42.9 71.2 54.1 77.5 47.2 62.5 77.9 51.9 59.9 47.5 37.6 79.1 46.6 58.1 61.4 43.7 44.5 40.7 40.7 38.4 39.5 47.5 30.9 56.5 45.5 98.2 39.3 31.8 52.4 89.7 53.9 37.2 57.2 49.2 33.3 40.3 72.7
16.9 23.4 22.1 22.6 20.6 21.7 19.0 21.6 22.1 22.7 22.8 21.4 22.6 22.1 22.6 22.6 19.2 22.9 22.4 21.6 22.5 23.2 20.3 22.3 22.4 23.3 24.1 18.2 22.0 19.5 19.1 19.1 22.3 22.8 19.1 15.2 17.9 22.2 21.7 23.4 20.5 19.0 18.9 21.6 22.4 22.6 21.5 21.4 20.8 15.8 22.4
0 19 5 4 1 2 11 2 15 4 1 2 23 8 1 15 2 13 7 4 6 2 10 2 3 4 2 2 2 2 2 1 2 0 2 2 1 1 1 2 1 1 0 1 12 0 0 0 0 7 7
2 0 0 0 0 0 2 0 17 0 1 0 0 10 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 0 0 0 10 4 0 1 5 11 2 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,699.97 1,148.58 949.50 1,028.57 849.48 901.50 1,243.73 974.48 1,629.81 1,525.76 1,187.64 972.51 1,909.92 1,752.86 1,291.63 1,359.69 1,552.67 1,507.74 1,182.61 1,203.57 1,605.81 1,049.55 1,398.77 1,351.65 1,108.54 1,545.82 1,121.56 1,637.92 1,377.74 1,568.69 1,080.62 2,756.24 1,963.01 1,620.84 885.41 1,145.48 1,043.44 1,630.79 2,153.00 1,551.75 943.50 825.49 2,353.25 1,415.73 1,334.63 1,758.88 2,464.22 1,971.03 1,313.72 1,110.67 1,296.67
Table S1 page 93/159
Annexin A4
ANXA4_HUMAN ANXA4
35,866
100.00%
11
11
54
42.00%
Fumarate hydratase, mitochondrial
FUMH_HUMAN FH
54,620
100.00%
4
4
7
9.41%
Proteasome subunit beta type-7
PSB7_HUMAN PSMB7
29,948
100.00%
6
8
24
22.70%
Coatomer subunit alpha
COPA_HUMAN COPA
138,331
100.00%
4
4
6
4.08%
Beta-hexosaminidase subunit beta
HEXB_HUMAN HEXB
63,095
100.00%
8
10
34
18.90%
DNA-binding protein A
DBPA_HUMAN CSDA
40,071
100.00%
3
3
6
20.70%
NLQNLLILTAIK NNLAGAEELFAR NNRPSEGPLQTR RPISADSAIMNPASK SVNESLNNLFITEEDYQALR TLQIFNIEMK TSIDAYDNFDNISLAQR VGYTPDWIFLLR VIQCFAETGQVQK VMEYINR VVGAMQLYSVDR WLLLTGISAQQNR AASGFNAMEDAQTLR AASGFNAMEDAQTLRK AEIDMLDIR DEGNYLDDALVR GAGTDEGCLIEILASR GLGTDDNTLIR GLGTDEDAIISVLAYR ISQTYQQQYGR QDAQDLYEAGEK SDTSFMFQR SETSGSFEDALLAIVK TPEEIR AAAEVNQDYGLDPK IANDIR IGGVTER SGLGELILPENEPGSSIMPGK ATEGMVVADK DGIVLGADTR FRPDMEEEEAK ITPLEIEVLEETVQTMDTS LDFLRPYTVPNK LDFLRPYTVPNKK DADSITLFDVQQK LLELGPKPEVAQQTR SILLSVPLLVVDNK TALNLFFK EISEVFPDQFIHLGGDEVEFK GSIVWQEVFDDK GSYSLSHVYTPNDVR KLESFYIQK LAPGTIVEVWK VEPLDFGGTQK VLDIIATINK VLPEFDTPGHTLSWGK AGEAPTENPAPPTQQSSAE GAEAANVTGPDGVPVEGSR NDTKEDVFVHQTAIK NPTYRPR SVGDGETVEFDVVEGEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
87.7 93.1 44.4 59.4 113.0 53.5 114.0 32.9 91.1 38.2 67.8 87.9 119.0 75.2 59.3 60.7 103.0 55.4 103.0 63.6 55.8 65.0 107.0 40.6 62.8 32.4 42.7 46.1 33.7 33.7 50.1 58.4 35.5 30.6 51.0 32.1 47.5 37.9 52.4 56.6 63.3 30.5 49.0 30.5 62.2 61.7 64.4 65.3 35.6 31.9 45.0
10.0 23.5 23.3 23.3 21.6 22.0 22.0 21.4 22.6 22.1 22.5 20.0 21.8 22.2 24.4 21.3 22.9 23.5 21.4 21.6 19.1 18.5 21.7 20.7 22.0 22.7 25.1 22.2 23.1 22.3 18.2 22.1 20.4 15.8 22.7 16.6 11.5 20.2 21.4 22.0 22.5 20.6 18.3 23.7 18.0 21.8 20.3 22.9 22.7 23.9 21.7
10 7 2 2 2 6 3 1 2 2 4 4 4 2 4 2 2 2 10 5 2 5 16 1 2 2 1 2 2 3 10 2 1 0 1 0 1 2 1 6 6 1 6 1 7 4 1 4 0 1 2
0 0 7 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 3 1 0 2 0 0 1 0 1 0 0 0 0 0 0 0 2 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,353.85 1,304.66 1,368.70 1,573.80 2,355.15 1,252.66 1,942.91 1,479.80 1,507.76 940.46 1,337.69 1,499.83 1,581.73 1,725.82 1,091.54 1,379.64 1,661.82 1,174.61 1,692.88 1,371.67 1,366.61 1,118.49 1,666.85 744.39 1,490.71 701.39 731.41 2,141.08 1,020.50 1,016.54 1,396.61 2,164.06 1,462.81 1,590.90 1,479.73 1,678.95 1,509.93 953.55 2,435.18 1,422.69 1,694.81 1,155.64 1,212.70 1,190.61 1,099.67 1,783.90 1,881.85 1,782.86 1,744.89 903.48 1,795.82
Table S1 page 94/159
F-actin-capping protein subunit beta CAPZB_HUMAN CAPZB
31,334
100.00%
6
6
51
Superoxide dismutase [Mn], mitochondrial
SODM_HUMAN SOD2
24,705
100.00%
4
4
19
Heat shock protein 105 kDa
HS105_HUMAN HSPH1
96,848
100.00%
19
22
52
Proteasome-associated protein ECM29 homolog Farnesyl pyrophosphate synthase
ECM29_HUMAN ECM29
204,278
99.90%
2
2
3
FPPS_HUMAN FDPS
48,259
100.00%
8
10
41
Sorbitol dehydrogenase
DHSO_HUMAN SORD
38,307
100.00%
3
3
7
Disintegrin and metalloproteinase domain-containing protein 10
ADA10_HUMAN ADAM10
84,125
100.00%
3
3
7
DCN1-like protein 1
DCNL1_HUMAN DCUN1D1
30,108
100.00%
5
5
7
23.80% LEVEANNAFDQYR RLPPQQIEK SGSGTMNLGGSLTR SPWSNKYDPPLEDGAMPSAR STLNEIYFGK YDPPLEDGAMPSAR 19.80% AIWNVINWENVTER GDVTAQIALQPALK GELLEAIKR YQEALAK 27.00% AFNDPFIQK DLLNMYIETEGK EKENLSYDLVPLK ENLSYDLVPLK FQEAEERPK FVVQNVSAQK GCALQCAILSPAFK IEVPLYSLLEQTHLK KVDQPPEAK LKETAENSLK LLTETEDWLYEEGEDQAK MFEELGQR NAVEEYVYEFR NQQITHANNTVSNFK QAYVDKLEELMK QDLPSLDEKPR SQFEELCAELLQK SVLDAAQIVGLNCLR VEDVSAVEIVGGATR VLGTAFDPFLGGK 1.63% AGEQLAPFLPQLVPR TLMSSGQMAPSSSNK 19.60% ATPEQYQILK CSWLVVQCLQR EVLEYNAIGGK IGTDIQDNK KQDADSLQR LKEVLEYNAIGGK QDFVQHFSQIVR VLTEDEMGHPEIGDAIAR 11.80% AMGAAQVVVTDLSATR LENYPIPEPGPNEVLLR VAIEPGAPR 4.55% AIDTIYQTTDFSGIR FPNIGVEK GGTFYVEPAER 20.80% FLDLWNK LDVATDNFFQNPELYIR MEQELKEPGR QFMIFTQSSEK YKDPQDENK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
94.7 44.1 89.8 41.4 76.9 50.1 71.2 70.7 50.6 43.4 42.6 52.4 76.8 53.1 42.6 68.8 37.1 61.3 36.9 32.6 115.0 37.5 32.6 88.2 51.6 29.9 40.1 81.1 89.5 67.8 37.2 72.0 43.5 44.5 47.2 44.6 51.2 53.4 42.3 75.2 120.0 67.0 33.3 74.4 49.0 36.4 30.4 81.3 31.7 50.5 30.4
21.9 18.8 21.5 20.5 22.8 20.0 22.6 16.7 19.6 22.4 23.1 21.6 21.4 22.3 23.1 23.0 22.6 18.0 20.5 22.6 21.1 21.6 21.4 22.0 22.3 22.0 22.7 20.8 22.9 21.2 16.8 18.3 22.5 23.2 23.3 22.8 24.4 19.7 22.9 22.0 22.4 20.6 19.2 22.4 22.7 21.9 23.3 23.4 21.5 22.5 22.4
4 4 17 0 18 1 8 4 5 2 4 2 2 1 5 2 1 2 2 1 2 2 2 2 2 0 2 2 4 6 2 1 4 2 2 4 3 2 0 5 4 2 1 4 2 1 1 2 0 2 1
0 0 0 7 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 2 9 8 0 0 0 0 0 0 0 0 1 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,568.73 1,108.65 1,337.65 2,234.02 1,171.60 1,518.69 1,743.88 1,424.81 1,028.61 822.44 1,079.55 1,441.69 1,547.83 1,290.69 1,133.56 1,119.62 1,535.77 1,783.00 1,011.55 1,132.62 2,168.99 1,009.48 1,418.66 1,715.85 1,482.75 1,297.68 1,594.78 1,628.88 1,501.79 1,321.72 1,635.92 1,557.69 1,190.64 1,448.71 1,192.62 1,003.51 1,060.54 1,433.80 1,503.77 1,952.94 1,605.83 1,950.03 909.52 1,700.85 903.49 1,225.59 935.50 2,055.02 1,232.59 1,345.65 1,136.52
Table S1 page 95/159
Serpin B5
SPB5_HUMAN SERPINB5
42,084
100.00%
14
16
63
Alcohol dehydrogenase [NADP+]
AK1A1_HUMAN AKR1A1
36,556
100.00%
11
13
94
48.50% ACLENLGLK DELNADHPFIYIIR DLTDGHFENILADNSVNDQTK DVEDESTGLEK DVPFGFQTVTSDVNK ELETVDFK GDTANEIGQVLHFENVK GQINNSIK HIFSEDTSDFSGMSETK IIELPFQNK ILVVNAAYFVGK LSSFYSLK QLNSESLSQWTNPSTMANAK SLNLSTEFISSTK 36.60% ALEALVAK AVPREELFVTSK AWRDPDEPVLLEEPVVLALAEK
Laminin subunit beta-1
LAMB1_HUMAN LAMB1
198,045
100.00%
28
31
217
DPDEPVLLEEPVVLALAEK GLEVTAYSPLGSSDR GLVQALGLSNFNSR MPLIGLGTWK QLNALNK SPAQILLR VFDFTFSPEEMK YIVPMLTVDGK 17.40% AAQNSGEAEYIEK AEMLLEEAKR AMDLDQDVLSALAEVEQLSK ATGQCLCLPNVIGQNCDR AVITVQRPGR DILAQSPAAEPLK DRVEDVMMER DVTEMMAQVEVK EALEEAEK ELAEQLEFIK ELDSLQTEAESLDNTVK ETVDSVER IEDPYSPR IPSWTGAGFVR IQNLLK ISELER ISGVIGPYR KAAQNSGEAEYIEK LEGEVR LHTLGDNLLDSR NFLTQDSADLDSIEAVANEVLK QSAEDILLK QYIQDR TLDGELDEKYK TPMTDVCR VESLSQVEVILQHSAADIAR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
31.7 71.1 80.4 63.3 105.0 34.2 74.5 36.6 65.0 46.8 39.1 30.1 106.0 82.6 50.8 35.8 71.4 109.0 90.2 72.9 53.7 42.7 60.5 71.4 35.7 83.1 46.8 90.1 95.3 29.9 62.0 28.4 48.2 32.0 57.1 142.0 60.0 35.7 47.8 35.8 35.8 58.3 61.9 33.4 61.1 88.2 52.5 30.4 38.6 53.5 54.2
23.8 21.9 20.6 19.7 22.4 22.1 22.4 24.0 16.1 21.4 16.0 23.8 21.2 22.0 17.2 21.2 19.4 20.7 23.3 22.0 20.5 21.7 15.3 20.2 21.7 20.8 23.9 22.2 20.4 17.6 19.5 18.1 20.5 21.4 22.8 23.0 23.1 22.3 22.0 19.0 24.3 21.2 22.8 22.7 22.0 21.4 22.3 23.4 22.7 18.6 18.3
1 2 2 4 14 1 6 1 3 6 2 1 4 2 2 2 0 9 10 2 28 2 8 8 2 25 2 2 7 0 4 0 3 2 13 20 17 4 12 3 2 20 4 4 5 2 9 1 2 5 0
0 0 6 0 0 0 8 0 0 0 0 0 0 0 0 0 18 2 0 1 0 0 0 0 0 0 0 2 0 6 0 2 0 0 0 0 0 0 0 0 0 0 10 0 2 0 0 0 0 0 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,017.54 1,715.88 2,346.09 1,221.55 1,653.81 980.49 1,870.93 873.48 1,933.81 1,101.63 1,293.76 944.51 2,207.04 1,426.74 814.50 1,375.76 2,489.33 2,076.11 1,551.77 1,475.80 1,115.63 800.46 897.55 1,492.67 1,251.67 1,409.65 1,205.62 2,191.08 2,075.94 1,096.66 1,352.74 1,311.57 1,411.65 918.44 1,219.66 1,891.91 934.45 976.47 1,190.63 728.47 746.40 961.55 1,537.75 702.38 1,353.71 2,392.19 1,016.56 822.41 1,310.65 995.43 2,165.16
Table S1 page 96/159
Disintegrin and metalloproteinase domain-containing protein 9
ADAM9_HUMAN ADAM9
90,538
100.00%
3
4
14
3.17%
Matrix metalloproteinase-14
MMP14_HUMAN MMP14
65,868
99.90%
2
2
2
4.30%
Proteasome subunit alpha type-5
PSA5_HUMAN PSMA5
26,393
100.00%
8
9
73
46.90%
Annexin A11
ANX11_HUMAN ANXA11
54,374
100.00%
4
4
10
7.92%
78 kDa glucose-regulated protein
GRP78_HUMAN HSPA5
72,317
100.00%
34
42
564
54.40%
YEPQLPDHWEK YSDIEPSTEGEVIFR DLLPEDFVVYTYNK MDDVYKEPLK NKDLLPEDFVVYTYNK SPQSLSAAIAAMQK VGEYATYEAIR AIGSASEGAQSSLQEVYHK EELEEVIKDI GVNTFSPEGR ITSPLMEPSSIEK LFQVEYAIEAIK LGSTAIGIQTSEGVCLAVEK LNATNIELATVQPGQNFHMFTK SSLIILK DAQELYAAGENR FNAVLCSR SETDLLDIR TPVLFDIYEIK AKFEELNMDLFR ALSSQHQAR DAGTIAGLNVMR DNHLLGTFDLTGIPPAPR EFFNGKEPSR ELEEIVQPIISK FEELNMDLFR IEIESFYEGEDFSETLTR IEWLESHQDADIEDFK IEWLESHQDADIEDFKAK IINEPTAAAIAYGLDK IINEPTAAAIAYGLDKR ITITNDQNR ITPSYVAFTPEGER KSDIDEIVLVGGSTR KSQIFSTASDNQPTVTIK KVTHAVVTVPAYFNDAQR LSSEDKETMEK LYGSAGPPPTGEEDTAEKDEL MKETAEAYLGK NELESYAYSLK NQLTSNPENTVFDAK NQLTSNPENTVFDAKR RALSSQHQAR SDIDEIVLVGGSTR SQIFSTASDNQPTVTIK STMKPVQK TFAPEEISAMVLTK TKPYIQVDIGGGQTK TWNDPSVQQDIK VEIIANDQGNR VLEDSDLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
32.8 68.5 51.3 48.5 71.4 70.8 65.9 125.0 57.6 52.4 73.7 89.6 40.8 71.0 67.5 49.8 59.5 38.0 66.2 84.0 61.1 106.0 97.6 54.1 73.3 49.5 99.4 97.4 60.3 114.0 110.0 63.0 85.5 124.0 90.9 29.0 52.5 110.0 59.6 77.4 104.0 93.9 50.3 77.2 103.0 31.9 99.5 65.5 71.4 80.0 30.6
21.5 21.7 22.0 23.0 21.6 23.0 21.9 21.8 23.4 23.3 23.8 19.5 21.1 21.2 12.0 21.1 23.2 23.9 20.4 22.4 21.6 23.6 22.2 22.4 18.9 20.8 20.4 20.9 20.8 21.5 19.3 23.3 22.4 22.3 20.5 20.0 21.6 21.0 22.0 22.1 22.9 21.8 21.7 22.6 22.0 23.1 22.8 20.9 22.4 22.6 23.9
2 19 6 3 4 1 1 7 3 4 11 23 2 0 12 1 6 1 2 22 4 19 20 3 26 7 9 5 0 30 21 14 33 21 2 0 6 26 9 22 26 2 0 10 39 1 44 4 24 56 1
0 0 0 0 1 0 0 5 0 0 0 0 0 6 0 0 0 0 0 12 0 0 18 0 0 0 0 4 10 4 19 0 0 13 2 2 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,441.68 1,741.83 1,715.85 1,237.61 1,957.99 1,402.74 1,271.63 1,961.96 1,216.63 1,063.52 1,431.74 1,423.78 2,033.06 2,474.25 773.51 1,336.61 966.48 1,061.55 1,337.74 1,512.75 997.52 1,217.63 1,934.01 1,210.59 1,397.79 1,329.62 2,164.99 1,974.91 2,174.04 1,659.90 1,816.00 1,074.55 1,566.78 1,588.85 1,965.03 2,016.07 1,296.60 2,175.99 1,256.62 1,316.64 1,677.81 1,833.91 1,153.62 1,460.76 1,836.93 918.51 1,536.80 1,604.87 1,430.69 1,228.63 918.48
Table S1 page 97/159
Aminoacyl tRNA synthase complex- AIMP1_HUMAN AIMP1 interacting multifunctional protein 1
34,335
100.00%
6
8
18
25.60%
Peroxiredoxin-2
PRDX2_HUMAN PRDX2
21,874
100.00%
7
8
42
35.90%
Gamma-glutamyl hydrolase
GGH_HUMAN GGH
35,948
100.00%
7
9
56
26.10%
31,370
100.00%
4
4
11
21.70%
Enoyl-CoA hydratase, mitochondrial ECHM_HUMAN ECHS1
26S proteasome non-ATPase regulatory subunit 12 CD166 antigen
PSD12_HUMAN PSMD12
52,888
100.00%
2
2
2
4.82%
CD166_HUMAN ALCAM
65,086
100.00%
13
14
95
25.20%
UMP-CMP kinase
KCY_HUMAN CMPK1
22,205
100.00%
8
9
32
55.60%
VLEDSDLKK VMEHFIK VTHAVVTVPAYFNDAQR VYEGERPLTK GAEADQIIEYLK IEILAPPNGSVPGDR ITFDAFPGEPDKELNPK KQQSIAGSADSKPIDVSR QQSIAGSADSKPIDVSR TVVSGLVNHVPLEQMQNR ATAVVDGAFK EGGLGPLNIPLLADVTR GLFIIDGK KEGGLGPLNIPLLADVTR LSEDYGVLK QITVNDLPVGR SVDEALR TDEGIAYR FFNVLTTNTDGK KPIIGILMQK LDLTEKDYEILFK NLDGISHAPNAVK SINGILFPGGSVDLR YLESAGAR YPVYGVQWHPEK ALNALCDGLIDELNQALK AQFAQPEILIGTIPGAGGTQR ICPVETLVEEAIQCAEK ISAQDAK DPNNLLNDWSQK LNSLMSLVNK ADIQMPFTCSVTYYGPSGQK ALFLETEQLK ALFLETEQLKK EMDPVTQLYTMTSTLEYK FVCMLVTEDNVFEAPTIVK LDVPQNLMFGK QIGDALPVSCTISASR SSNTYTLTDVR SSNTYTLTDVRR SVQYDDVPEYK SVQYDDVPEYKDR VFKQPSKPEIVSK YEKPDGSPVFIAFR EMDQTMAANAQK FLIDGFPR IQTYLQSTKPIIDLYEEMGK KNPDSQYGELIEK MKPLVVFVLGGPGAGK NQDNLQGWNK SVDEVFDEVVQIFDKEG
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
42.3 33.3 94.0 53.5 66.0 47.3 62.8 54.0 94.7 52.9 40.6 80.7 33.1 86.1 43.1 82.9 44.8 47.9 72.1 33.4 62.3 78.0 46.5 32.3 33.0 141.0 91.7 97.4 41.4 51.9 31.6 87.3 74.0 37.8 109.0 86.3 59.8 103.0 67.4 40.5 31.7 44.5 37.2 48.8 57.4 58.9 46.0 72.9 71.4 36.0 39.3
23.4 24.2 22.2 22.7 22.8 21.7 22.4 21.0 22.3 21.2 22.9 16.3 18.1 14.9 22.7 21.0 24.9 21.2 22.1 15.1 21.0 22.2 20.8 23.2 22.8 21.8 19.1 21.7 25.4 21.3 21.9 19.4 20.7 17.7 21.0 22.1 22.4 22.7 21.8 22.5 20.6 21.2 17.6 22.3 18.9 22.0 20.9 23.1 16.8 20.6 21.6
6 1 9 15 2 2 2 0 1 0 4 10 2 5 4 23 2 4 10 2 8 11 7 1 0 2 4 4 1 1 1 5 8 3 29 4 11 5 16 1 1 2 0 2 2 11 0 2 1 2 1
0 0 27 0 0 0 2 2 3 4 0 0 0 11 0 0 0 0 0 2 13 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 5 0 0 6 0 4 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,046.57 903.48 1,887.97 1,191.64 1,349.70 1,534.82 1,917.96 1,886.99 1,758.90 2,021.06 978.53 1,734.98 862.50 1,863.07 1,023.54 1,211.68 789.41 924.44 1,356.68 1,156.71 1,626.86 1,335.70 1,544.84 866.44 1,502.74 1,971.02 2,125.14 1,988.97 732.39 1,443.69 1,118.62 2,266.02 1,191.66 1,319.76 2,166.00 2,228.10 1,261.66 1,674.85 1,256.61 1,412.71 1,342.62 1,613.74 1,486.86 1,625.83 1,337.58 964.53 2,386.22 1,520.76 1,585.91 1,216.57 1,954.93
Table S1 page 98/159
Glucosamine-6-phosphate isomerase GNPI1_HUMAN GNPDA1 1
32,651
100.00%
6
7
18
Galactocerebrosidase
GALC_HUMAN GALC
77,019
99.90%
2
2
3
Eukaryotic translation initiation factor 3 subunit E
EIF3E_HUMAN EIF3E
52,205
100.00%
5
5
9
45 kDa calcium-binding protein
CAB45_HUMAN SDF4
41,789
100.00%
12
14
73
Plasminogen activator inhibitor 1
PAI1_HUMAN SERPINE1
45,042
100.00%
17
22
726
YGYTHLSAGELLR 30.10% AIEEGVNHMWTVSAFQQHPR LVDPLYSIK TFNMDEYVGLPR TLAMDTILANAR VPTMALTVGVGTVMDAR YFTLGLPTGSTPLGCYK 4.09% EFDGIGAVSGGGATSR SLWTDIPVNFPK 15.30% LGHVVMGNNAVSPYQQVIEK LKETIDNNSVSSPLQSLQQR LNMTPEEAER MLFDYLADK QEYLDTLYR 31.20% AVDPDGDGHVSWDEYK DLGGFDEDAEPR DLGGFDEDAEPRR EVADAIR GFHQEVFLGK LEMDGHLNR LMVIFSK QMIAVADENQNHHLEPEEVLK TAEHFQEAMEESK VDVNTDR VDVNTDRK YSEFFTGSK 48.30% ELMGPWNKDEISTTDAIFVQR FIINDWVK FSLETEVDLR GAVDQLTR GMAPALR GMISNLLGK HNPTGTVLFMGQVMEP IDDKGMAPALR KPLENLGMTDMFR LVQGFMPHFFR MAPEEIIMDRPFLFVVR QFQADFTSLSDQEPLHVAQALQK
Ras-related protein Ral-A
RALA_HUMAN RALA
23,549
100.00%
2
2
2
Peroxiredoxin-6
PRDX6_HUMAN PRDX6
25,018
100.00%
8
11
38
QVDFSEVER SDGSTVSVPMMAQTNK TPFPDSSTHR VFQQVAQASK VFQQVAQASKDR 14.10% AEQWNVNYVETSAK VKEDENVPFLLVGNK 41.50% DGDSVMVLPTIPEEEAK ELAILLGMLDPAEKDEK LPFPIIDDR LSILYPATTGR PGGLLLGDVAPNFEANTTVGR VATPVDWKDGDSVMVLPTIPEEEAK
95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
29.9 32.0 30.3 75.3 93.6 91.8 72.6 70.7 37.7 32.0 39.6 50.1 38.9 33.3 90.1 82.3 39.9 31.5 40.3 51.8 33.1 48.2 78.9 45.7 34.0 32.3 45.4 51.7 55.6 58.5 35.2 54.8 89.0 57.9 65.8 47.5 36.6 90.9 80.7 60.6 49.4 78.7 50.6 57.4 33.8 54.7 67.6 59.3 59.0 77.2 35.6
22.7 21.8 16.1 20.9 23.3 22.6 22.0 22.0 22.1 21.4 20.6 18.9 20.9 21.8 17.5 16.0 21.2 23.5 24.2 19.9 20.2 22.5 17.8 23.3 23.4 21.2 20.8 22.5 23.2 23.4 25.7 21.4 21.1 23.9 23.2 23.0 21.8 21.1 22.3 20.1 20.6 22.3 22.8 21.9 20.4 22.0 21.2 20.9 19.5 20.3 21.1
0 0 1 8 2 2 2 1 2 0 0 2 2 1 4 13 1 1 2 4 1 0 15 11 3 1 0 24 21 19 3 41 113 13 34 13 0 1 52 57 29 53 2 1 1 5 5 8 3 4 0
3 2 0 0 0 1 0 0 0 2 2 0 0 0 0 0 0 0 0 2 0 7 8 0 0 0 30 0 0 0 0 0 0 9 24 3 17 130 0 0 38 0 0 0 0 0 2 0 0 2 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2
1,479.76 2,353.11 1,047.61 1,457.67 1,289.69 1,749.89 1,874.94 1,480.70 1,416.75 2,199.12 2,257.18 1,205.55 1,131.54 1,200.59 1,789.77 1,320.57 1,476.67 773.42 1,161.61 1,100.52 853.49 2,444.19 1,536.66 818.40 946.50 1,065.49 2,466.20 1,034.57 1,208.62 859.46 731.39 932.52 1,789.83 1,202.62 1,551.77 1,394.70 2,095.07 2,601.30 1,108.53 1,684.75 1,144.54 1,105.60 1,376.73 1,638.78 1,700.92 1,829.88 1,885.00 1,085.60 1,191.67 2,098.09 2,742.36
Table S1 page 99/159
VVFVFGPDK VVFVFGPDKK EAFEETHLTSLDPVK FFTNFESR GEEDWLYER EDTPNSVWEPAK EPTMYVGSTSVQTSR GDSGGAFAVQDPNDKTK SDFSNEER SSNNPHSPIVEEFQVPYNK TMQENSTPRED TNFDNDIALVR FRGPFTDVVTTNLK GPFTDVVTTNLK LGNPTDR ADAEEEAATR DLEDKEGEIQAGAK EAVAPVQEESDLEK SVSTPSEAGSQDSGDGAVGSR DTNGENIAESLVAEGLATR DTPDEPWAFPAR DYVAPTANLDQK EADGSETPEPFAAEAK GDVGLGLVK LGTLSPAFSTR NDIASHPPVEGSYAPR NLPGLVQEGEPFSEEATLFTK QFLPFLQR QINLSNIR SLLSAEEAAK SSHYDELLAAEAR TDAVDSVVR VITEYLNAQESAK VMQVLNADAIVVK
29,970
100.00%
3
3
4
12.30%
76,666
100.00%
7
7
22
13.50%
VAPB_HUMAN VAPB
27,211
100.00%
3
3
3
8.64%
Cytoplasmic dynein 1 intermediate chain 2
DC1I2_HUMAN DYNC1I2
71,438
100.00%
4
4
8
9.25%
Staphylococcal nuclease domaincontaining protein 1
SND1_HUMAN SND1
101,981
100.00%
16
18
44
23.50%
Heme-binding protein 2
HEBP2_HUMAN HEBP2
22,858
100.00%
4
5
24
Latent-transforming growth factor beta-binding protein 2
LTBP2_HUMAN LTBP2
195,025
100.00%
7
7
29
Protein CYR61
CYR61_HUMAN CYR61
42,008
100.00%
4
4
14
26,905
100.00%
14
14
149
23.90% APEDAGPQPGSYEIR NNEVWLIQK NQEQLLTLASILR VYYTAGYNSPVK 4.78% EQDAPVAGLQPVER GAGGQSMSEAPTGDHAPAPTR QICCCSR SSAAGEGTLAR SSGALPGPAER STPLGQQQPAPR VTNDVCSEPLR 13.10% ELGFDASEVELTR GLECNFGASSTALK ILYNPLQGQK IYQNGESFQPNCK 56.80% FLDGNELTLADCNLLPK
Pyridoxine-5'-phosphate oxidase
PNPO_HUMAN PNPO
Complement C1s subcomponent
C1S_HUMAN
Vesicle-associated membrane protein-associated protein B/C
C1S
VNVTVDYIRPASPATETVPAFSER
Chloride intracellular channel protein CLIC1_HUMAN CLIC1
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
30.5 41.2 58.2 52.2 33.7 42.2 78.8 45.7 46.5 31.0 41.0 68.8 29.8 59.7 32.6 74.7 65.3 55.6 103.0 98.2 34.9 45.8 79.3 35.3 37.3 69.0 88.1 39.2 40.3 37.2 46.5 34.4 63.2 76.3 42.2 78.0 55.5 108.0 75.2 52.8 58.8 34.2 59.4 32.1 33.9 36.3 98.3 74.0 35.4 73.1 72.0
21.8 18.9 22.0 21.5 19.0 21.1 21.6 24.1 14.9 21.2 16.1 23.5 20.4 22.0 20.9 18.3 22.4 21.6 20.0 21.8 19.3 23.5 19.2 20.3 21.8 21.6 21.7 20.3 21.8 24.0 22.0 24.7 22.1 19.6 21.1 21.9 22.8 18.5 22.6 23.3 19.7 13.0 22.8 22.0 22.4 22.0 22.6 22.0 21.9 20.5 21.8
1 4 2 1 1 3 3 1 4 0 3 5 0 1 1 2 2 2 2 1 2 2 4 1 2 2 6 6 2 2 2 1 2 4 0 4 4 11 4 3 0 1 3 1 1 1 8 4 1 1 7
0 2 0 0 0 0 0 0 0 3 0 0 1 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 0 0 1 0 0 19 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,007.56 1,135.65 1,715.85 1,047.49 1,196.52 1,372.64 1,642.77 1,706.80 983.41 2,186.05 1,323.55 1,277.65 1,594.86 1,291.69 772.40 1,062.47 1,502.73 1,543.75 1,950.86 1,959.96 1,401.64 1,334.66 1,648.73 857.51 1,149.63 1,709.82 2,306.16 1,048.59 957.55 1,018.54 1,461.70 961.50 1,465.75 1,415.79 2,619.34 1,586.75 1,143.62 1,498.86 1,361.67 1,508.77 2,010.89 983.39 1,019.51 1,041.53 1,279.68 1,289.62 1,465.72 1,454.70 1,173.66 1,584.71 1,932.97
Table S1 page 100/159
1
FSAYIK GFTIPEAFR GVTFNVTTVDTK GVTFNVTTVDTKR IGNCPFSQR KFLDGNELTLADCNLLPK LAALNPESNTAGLDIFAK LFMVLWLK LHIVQVVCK NSNPALNDNLEK VLDNYLTSPLPEEVDETSAEDEGVSQR VLDNYLTSPLPEEVDETSAEDEGVSQRK
Basal cell adhesion molecule
BCAM_HUMAN BCAM
67,386
100.00%
15
18
174
Transgelin-2
TAGL2_HUMAN TAGLN2
22,374
100.00%
12
15
86
Exportin-T
XPOT_HUMAN XPOT
109,949
100.00%
3
3
6
1,4-alpha-glucan-branching enzyme GLGB_HUMAN GBE1
80,445
100.00%
4
4
7
EIF3L_HUMAN EIF3L
66,711
100.00%
7
7
11
Eukaryotic translation initiation factor 3 subunit L
YLSNAYAR 28.70% AGAAGTAEATAR EGDEVTLICSAR EGDTVQLLCR GDGSPSPEYTLFR GRSPPYQLDSQGR LASAEMQGSELQVTMHDTR LEVPVEMNPEGYMTSR LNVFAKPEATEVSPNK LSVPPLVEVMR LSWSQLGGSPAEPIPGR SPPYQLDSQGR TAEIEPK VAYLDPLELSEGK VEDYDAADDVQLSK VTSALSR 67.30% DDGLFSGDPNWFPK DDGLFSGDPNWFPKK DGTVLCELINALYPEGQAPVK DGTVLCELINALYPEGQAPVKK GASQAGMTGYGMPR GPAYGLSR IQASTMAFK NFSDNQLQEGK NVIGLQMGTNR QMEQISQFLQAAER TLMNLGGLAVAR YGINTTDIFQTVDLWEGK 4.26% DLQEFIPLINQITAK LAQVSPELLLASVR NAQEALQAIETK 8.26% IVLDSDAAEYGGHQR LLEIDPYLKPYAVDFQR VALILQNVDLPN YGWLAAPQAYVSEK 17.00% LAGFLDLTEQEFR QLEVYTSGGDPESVAGEYGR QYEQQTYQVIPEVIK VFSDEVQQQAQLSTIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
34.2 44.0 101.0 35.3 53.3 41.1 110.0 52.5 47.3 78.8 44.2 51.0 45.4 104.0 54.6 48.8 63.1 43.0 34.5 86.6 92.1 46.1 85.8 63.1 37.9 61.4 129.0 37.8 58.5 31.6 72.6 48.4 71.7 42.1 41.1 75.7 62.2 95.1 86.6 111.0 39.8 52.3 45.2 113.0 36.1 42.7 48.1 72.0 110.0 55.9 59.4
19.5 22.1 21.6 21.1 23.3 21.5 21.5 18.3 17.9 22.4 19.3 20.1 20.3 23.2 22.2 22.8 21.9 22.9 20.7 20.2 21.4 18.3 21.6 22.9 21.9 22.5 20.3 22.2 20.0 22.2 20.5 21.1 18.1 25.0 21.6 21.0 23.6 22.4 21.5 22.3 18.7 14.3 22.9 22.1 20.4 17.9 22.3 22.5 20.6 21.8 22.2
4 4 21 1 6 1 50 9 4 27 0 0 6 36 3 2 13 2 0 16 8 6 10 14 4 28 14 4 6 1 1 1 14 5 2 10 6 8 11 8 1 4 1 2 0 1 2 2 1 2 1
0 0 0 0 0 0 0 0 0 0 7 2 0 0 0 0 0 2 4 0 7 0 1 0 0 0 0 0 0 1 0 4 0 0 0 0 0 8 0 0 0 0 0 0 2 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
728.40 1,037.54 1,281.67 1,437.77 1,078.51 2,061.07 1,844.98 1,065.62 1,095.64 1,328.64 2,992.39 3,120.49 957.48 1,046.52 1,349.64 1,190.58 1,425.67 1,460.72 2,119.98 1,883.85 1,743.93 1,239.71 1,751.91 1,247.60 787.42 1,433.75 1,567.71 733.42 1,594.72 1,722.81 2,287.16 2,415.26 1,415.60 820.43 1,012.51 1,279.59 1,202.63 1,694.82 1,215.69 2,100.03 1,742.97 1,495.88 1,315.69 1,630.78 2,080.11 1,308.75 1,582.79 1,538.79 2,113.97 1,865.97 1,848.95
Table S1 page 101/159
Exportin-2
XPO2_HUMAN CSE1L
110,404
100.00%
10
10
17
14.30%
Neutrophil gelatinase-associated lipocalin
NGAL_HUMAN LCN2
22,571
100.00%
9
11
135
51.00%
Serpin B7
SPB7_HUMAN SERPINB7
42,888
100.00%
4
4
9
11.30%
RNA-binding protein 8A
RBM8A_HUMAN RBM8A
19,871
99.50%
2
2
5
17.20%
Exportin-7
XPO7_HUMAN XPO7
123,895
99.50%
2
2
3
2.48%
Coatomer subunit gamma
COPG_HUMAN COPG
97,701
100.00%
5
5
9
8.35%
Midkine
MK_HUMAN
15,567
99.50%
2
2
4
11.90%
Polypeptide Nacetylgalactosaminyltransferase 1
GALT1_HUMAN GALNT1
64,202
100.00%
7
7
17
14.70%
AP-1 complex subunit beta-1
AP1B1_HUMAN AP1B1
104,621
99.50%
2
2
2
6.74%
Ubiquitin carboxyl-terminal hydrolase isozyme L3
UCHL3_HUMAN UCHL3
26,165
100.00%
4
5
18
27.40%
MDK
VSGGPSLEQR VYEIQDIYENSWTK VYELQASR ALTLPGSSENEYIMK DLEGSDIDTR EHDPVGQMVNNPK GSNTIASAAADKIPGLLGVFQK LLQTDDEEEAGLLELLK LVLDAFALPLTNLFK QLSDAISIIGR SANVNEFPVLK TGNIPALVR YGALALQEIFDGIQPK ELTSELKENFIR ITLYGR MYATIYELK MYATIYELKEDK SYPGLTSYLVR TFVPGCQPGEFTLGNIK VPLQQNFQDNQFQGK VVSTNYNQHAMVFFK WYVVGLAGNAILR ADLSGIASGGR LTFQNLMEWTNPR QLPQSTLFR YVEVFFPQFK GYTLVEYETYK MREDYDSVEQDGDEPGPQR LYGDDALDNALQTFIK NSIVNSQPPEK ELAPAVSVLQLFCSSPK QEIFQEQLAAVPEFR SIATLAITTLLK SSPEPVALTESETEYVIR TLEEAVGNIVK EFGADCK YNAQCQETIR ATEEDSQVPSIR ATPYTFPGGTGQIINK GNQLWEYDPVK HYFSLGEIR NFFYIISPGVTK TPTMAGGLFSIDR VDYGDISSR DIPNENEAQFQIR LASQANIAQVLAELK LQSSNIFTVAK MEPLNNLQVAVK NVEGQDMLYQSLK FLEESVSMSPEER SQGQDVTSSVYFMK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
52.7 82.2 47.2 62.9 47.8 46.3 30.8 94.2 32.3 58.8 43.9 40.5 83.9 73.1 37.8 54.7 64.8 79.9 57.1 91.3 58.1 65.1 46.0 51.4 49.0 42.8 60.7 51.5 66.5 32.5 42.7 38.3 65.3 109.0 34.7 36.8 42.4 56.5 41.7 55.5 39.6 63.2 64.6 37.7 57.6 58.9 44.5 46.1 53.5 89.0 75.7
21.4 23.2 22.7 21.8 20.8 21.6 16.9 21.1 13.2 21.4 23.0 18.0 20.7 21.1 19.7 22.4 22.8 22.0 22.3 23.0 22.5 19.1 22.8 22.9 22.3 24.5 22.6 14.9 22.1 21.7 21.4 22.1 11.1 22.6 22.5 16.0 21.0 21.5 22.8 24.1 22.9 21.4 22.8 21.0 22.5 17.6 21.2 22.3 22.3 20.4 20.8
2 2 1 2 2 2 0 2 1 2 2 1 2 8 7 12 6 17 8 33 8 29 1 2 4 2 2 0 2 1 1 2 1 4 1 2 2 3 2 2 2 2 4 2 1 2 1 4 2 5 3
0 0 0 0 0 0 1 0 0 0 0 0 0 5 0 0 0 0 0 2 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,029.53 1,787.85 965.51 1,668.82 1,120.51 1,480.69 2,158.19 1,929.01 1,674.98 1,172.66 1,217.65 940.56 1,762.94 1,478.79 722.42 1,147.57 1,503.74 1,255.67 1,864.93 1,790.88 1,784.88 1,431.81 1,003.52 1,665.81 1,089.61 1,303.67 1,365.66 2,238.92 1,796.91 1,212.62 1,845.98 1,804.92 1,244.78 2,006.99 1,172.65 826.34 1,282.59 1,331.64 1,664.87 1,348.65 1,121.57 1,385.75 1,365.68 1,011.47 1,573.76 1,568.90 1,207.67 1,371.73 1,540.73 1,555.70 1,576.73
Table S1 page 102/159
Putative tropomyosin alpha-3 chain- TPM3L_HUMAN --like protein
26,252
100.00%
4
5
15
Ribosome maturation protein SBDS SBDS_HUMAN SBDS
28,746
100.00%
3
3
3
Cleavage stimulation factor subunit 1 CSTF1_HUMAN CSTF1
48,341
100.00%
3
3
4
VTHETSAHEGQTEAPSIDEK WLPLEANPEVTNQFLK 24.70% AELAESR HIAEEADR IQVLQQQADDAEER IQVLQQQADDAEERAER LKEAETR LMDQNLK MELQEIQLK 12.80% DLDEVLQTHSVFVNVSK GEVQVSDKER SGVEKDLDEVLQTHSVFVNVSK
Leucine-rich repeat flightlessinteracting protein 1
LRRF1_HUMAN LRRFIP1
89,235
100.00%
3
3
11
Heat shock protein HSP 90-alpha
HS90A_HUMAN HSP90AA1
84,645
100.00%
23
29
321
8.58% LGMENDDTAVQYAIGR NLLSLGHNNIVR YTGAGLSGR 4.70% EFTNQEAAEPK IDGATQSSPAEPK SAVEAQNEVTENPK 47.10% ADLINNLGTIAK ALLFVPR APFDLFENR APFDLFENRK DNSTMGYMAAK DQVANSAFVER EDQTEYLEER EGLELPEDEEEK EGLELPEDEEEKK EKYIDQEELNK ELHINLIPNK ELHINLIPNKQDR ELISNSSDALDK ELISNSSDALDKIR EMLQQSK GVVDSEDLPLNISR HFSVEGQLEFR HIYYITGETK HLEINPDHSIIETLR HNDDEQYAWESSAGGSFTVR HSQFIGYPITLFVEK HSQFIGYPITLFVEKER IMKDILEK IRYESLTDPSK KHLEINPDHSIIETLR KHSQFIGYPITLFVEK LGIHEDSQNR LSELLR LVTSPCCIVTSTYGWTANMER NPDDITNEEYGEFYK RAPFDLFENR SLTNDWEDHLAVK TDTGEPMGR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
96.7 72.3 35.7 38.5 108.0 59.9 42.4 43.1 56.2 38.2 35.4 33.0 68.0 36.0 50.3 43.3 45.4 84.8 74.8 45.0 81.0 34.0 73.2 78.7 49.1 58.8 43.1 55.1 34.5 44.6 80.1 99.6 50.8 113.0 64.6 43.0 85.7 133.0 68.5 28.2 36.0 47.5 23.5 29.9 49.0 44.8 94.9 98.2 46.6 83.6 55.4
20.9 20.7 24.2 22.0 22.1 22.0 24.5 23.8 23.9 21.9 24.0 21.0 21.9 19.2 22.2 21.0 21.7 21.3 20.9 18.9 22.4 22.8 16.0 22.9 18.8 20.1 20.8 23.3 20.0 20.2 23.3 22.3 23.4 22.4 23.7 22.1 21.8 17.3 20.8 20.5 21.2 22.3 19.0 18.9 23.1 23.2 20.9 17.2 23.1 21.8 19.8
2 6 1 4 9 1 6 1 5 0 1 0 2 1 1 2 6 3 86 17 16 1 11 32 12 3 2 4 1 5 18 5 6 54 7 11 10 7 23 0 1 2 0 0 6 17 3 26 12 97 10
2 0 0 0 0 3 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 1 0 0 4 0 42 54 9 1 0 0 0 1 9 0 0 0 1 7 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,166.00 1,899.00 775.40 940.45 1,642.80 1,998.98 846.47 877.45 1,131.61 1,929.99 1,146.58 2,430.25 1,752.82 1,349.77 881.45 1,263.59 1,300.64 1,515.73 1,242.71 815.51 1,108.54 1,236.64 1,204.50 1,235.60 1,311.57 1,416.64 1,544.73 1,408.70 1,190.69 1,589.88 1,291.64 1,560.82 879.42 1,513.79 1,348.67 1,224.63 1,786.95 2,255.96 1,778.95 2,064.09 989.57 1,308.68 1,915.04 1,907.04 1,168.57 730.45 2,462.12 1,833.78 1,264.64 1,527.74 963.42
Table S1 page 103/159
Oligoribonuclease, mitochondrial
ORN_HUMAN REXO2
26,816
99.90%
2
2
3
Interleukin-1 receptor-like 1
ILRL1_HUMAN IL1RL1
63,341
100.00%
8
11
118
TLTIVDTGIGMTK TLVSVTK VILHLK VILHLKEDQTEYLEER YESLTDPSK YESLTDPSKLDSGK YIDQEELNK YYTSASGDEMVSLK 10.10% ALDDISESIK QPDELLDSMSDWCK 18.20% DEQGFSLFPVIGAPAQNEIK DEQGFSLFPVIGAPAQNEIKEVEIGK
FLPAAVADSGIYTCIVR IQQEEGQNQSFSNGLACLDMVLR
ITDFGEPR QSWGLENEALIVR SFTVKDEQGFSLFPVIGAPAQNEIK
T-complex protein 1 subunit zeta
TCPZ_HUMAN CCT6A
58,007
100.00%
6
6
19
VFASGQLLK 17.50% ALQFLEEVK DGNVLLHEMQIQHPTASLIAK GIDPFSLDALSK IITEGFEAAK VATAQDDITGDGTTSNVLIIGELLK
Cellular nucleic acid-binding protein CNBP_HUMAN CNBP
19,444
100.00%
4
5
6
Gamma-synuclein
SYUG_HUMAN SNCG
13,312
99.50%
2
3
4
Plastin-3
PLST_HUMAN PLS3
70,796
100.00%
16
20
80
VLAQNSGFDLQETLVK 25.40% CGESGHLAK CGETGHVAINCSK GFQFVSSSLPDICYR TSEVNCYR 13.40% EDLRPSAPQQEGEASK KEDLRPSAPQQEGEASK 38.60% AESMLQQADK ALENDPDCR ANDDIIVNWVNR AYFHLLNQIAPK DGETLEELMK HVIPMNPNTDDLFK IDINMSGFNETDDLKR IKVPVDWSK INNFSADIKDSK KLENCNYAVELGK LSPEELLLR MINLSVPDTIDER NEALAALLR QFVTPADVVSGNPK RYTLNVLEDLGDGQK SGNLTEDDKHNNAK VYALPEDLVEVKPK YAFVNWINK YAVSMAR YPALTKPENQDIDWTLLEGETR YTLNVLEDLGDGQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
109.0 40.7 35.5 69.3 43.0 67.9 60.6 74.2 59.6 43.1 79.3 48.1 115.0 53.7 56.2 98.5 38.1 61.7 45.3 27.8 37.9 46.1 88.9 89.5 32.1 51.8 48.8 44.3 37.3 35.5 63.1 37.8 55.1 43.1 52.5 32.8 86.2 43.3 61.2 63.0 67.1 66.8 79.1 87.7 32.9 48.6 60.2 34.8 31.3 63.3 90.0
22.1 19.6 7.8 22.0 23.0 22.6 23.1 19.8 23.8 19.6 21.7 19.8 21.5 20.8 23.1 21.9 20.6 18.2 21.9 20.5 22.9 21.8 18.6 21.1 18.6 17.6 22.3 17.9 21.5 22.0 22.3 16.5 21.8 21.0 21.2 21.9 21.2 21.3 22.8 22.8 17.1 22.8 18.2 22.6 22.0 20.6 18.7 20.9 20.5 21.8 22.3
57 4 7 7 9 14 21 37 2 1 18 0 6 2 31 26 0 18 4 0 2 4 4 4 1 1 2 1 0 0 3 3 2 0 3 0 2 0 4 2 7 24 16 11 0 1 4 1 1 2 7
0 0 0 102 0 3 0 0 0 0 3 8 3 1 0 0 2 0 0 1 0 0 0 0 0 1 0 0 1 2 0 0 0 4 0 2 4 4 0 0 0 0 0 0 1 2 2 0 0 5 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,365.73 747.46 722.49 2,015.05 1,039.49 1,539.75 1,151.56 1,566.70 1,090.56 1,723.73 2,160.10 2,815.45 1,852.96 2,653.24 934.46 1,514.80 2,722.41 962.57 1,076.60 2,331.21 1,262.66 1,078.58 2,544.34 1,761.94 958.44 1,432.63 1,775.84 1,028.45 1,741.84 1,869.93 1,136.53 1,089.46 1,428.72 1,414.78 1,180.54 1,656.81 1,883.88 1,071.62 1,351.69 1,537.77 1,069.63 1,518.75 970.57 1,458.76 1,720.89 1,542.72 1,599.90 1,154.60 813.39 2,589.28 1,564.79
Table S1 page 104/159
Putative phospholipase B-like 1
PLBL1_HUMAN PLBD1
63,240
100.00%
2
2
3
ATP synthase subunit beta, mitochondrial
ATPB_HUMAN ATP5B
56,543
100.00%
11
12
40
Creatine kinase U-type, mitochondrial
KCRU_HUMAN CKMT1A
47,020
100.00%
5
5
10
Nodal modulator 1
NOMO1_HUMAN NOMO1
134,308
100.00%
5
5
11
Lysosome-associated membrane glycoprotein 1
LAMP1_HUMAN LAMP1
44,865
100.00%
3
3
17
45,963
99.90%
2
2
4
Arrestin domain-containing protein 1 ARRD1_HUMAN ARRDC1 Transforming growth factor beta-2
TGFB2_HUMAN TGFB2
47,731
100.00%
2
2
13
Transformer-2 protein homolog alpha Peptidyl-prolyl cis-trans isomerase FKBP2
TRA2A_HUMAN TRA2A
32,671
99.90%
2
2
8
FKBP2_HUMAN FKBP2
15,632
100.00%
3
4
5
Basement membrane-specific heparan sulfate proteoglycan core protein
PGBM_HUMAN HSPG2
3.98% QVIPETLLSWQR TTGWGILEIR 30.60% AIAELGIYPAVDPLDSTSR FTQAGSEVSALLGR IGLFGGAGVGK IMDPNIVGSEHYDVAR IMNVIGEPIDER IPSAVGYQPTLATDMGTMQER TIAMDGTEGLVR TVLIMELINNVAK VALVYGQMNEPPGAR VLDSGAPIKIPVGPETLGR VVDLLAPYAK 13.70% GTGGVDTAATGGVFDISNLDR HTTDLDASK LGYILTCPSNLGTGLR RGTGGVDTAATGGVFDISNLDR VVVDALSGLK 5.07% DGENYVVLLDSTLPR EQQLAEIEAR IQSTVTQPGGK SSIDSEPALVLGPLK VQVMVPEAETR 8.63% ALQATVGNSYK FFLQGIQLNTILPDAR TVESITDIR 5.08% LGAPLPFR VVYSPGEPLAGTVR 5.80% FAGIDGTSTYTSGDQK IELYQILK 8.16% GFAFVYFER YGPLSGVNVVYDQR 28.90% KLVIPSELGYGER LEDGTEFDSSLPQNQPFVFSLGTGQVIK
468,761
100.00%
75
85
619
LVIPSELGYGER 20.90% AFAHLQVPER AGFFGDAMK AGLSSGFIGCVR AHSSAGQQVAR AMDFNGILTIR ASYAQQPAESR ATATSCRPCPCPYIDASR AVTLECVSAGEPR CAPGYYGNPSQGQPCQR CEQCQPGYYGDAQR CESCAPGYEGNPIQPGGK CKNNVVGR CSATGSPTPTLEWTGGPGGQLPAK
DFISLGLQDGHLVFR EDGRPVPSGTQQR EGGQLPPGHSVQDGVLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
54.4 50.9 73.2 87.2 45.8 42.2 56.2 53.1 60.0 76.2 79.7 62.1 40.6 106.0 37.8 38.5 34.8 65.1 53.8 56.0 30.8 86.9 34.7 41.2 75.9 34.8 42.8 52.2 108.0 43.8 52.2 56.5 36.8 28.1 63.2 42.8 32.8 46.2 45.0 35.9 70.6 54.8 97.2 62.3 49.0 104.0 34.1 82.8 77.6 35.9 30.4
20.9 22.6 21.7 22.1 20.4 21.5 22.5 21.4 22.9 19.4 23.0 14.0 19.3 22.2 20.9 20.8 22.2 20.3 22.3 23.3 23.0 20.6 22.8 22.8 18.0 23.3 19.8 21.1 20.7 14.0 23.2 22.5 20.3 21.1 22.3 21.8 17.2 23.9 21.1 22.6 22.3 19.4 22.7 16.4 11.8 17.2 24.1 21.8 20.9 21.9 23.2
1 2 4 4 6 0 4 2 3 2 4 2 2 2 1 2 0 4 3 2 1 4 1 6 10 1 2 2 7 6 2 6 1 0 2 4 2 2 2 4 61 0 8 1 2 2 1 1 15 3 0
0 0 0 0 0 2 0 0 0 0 0 5 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 4 0 0 0 0 0 2 0 0 0 0 0 0 8 4 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,469.81 1,145.63 1,988.03 1,435.75 975.56 1,831.87 1,401.71 2,298.08 1,278.64 1,473.84 1,617.81 1,919.10 1,088.64 2,022.97 987.47 1,734.92 2,179.07 1,000.60 1,690.87 1,186.61 1,115.61 1,525.85 1,274.64 1,151.61 1,846.02 1,033.55 870.52 1,444.78 1,647.75 1,019.61 1,135.56 1,566.79 1,460.81 3,053.51 1,332.72 1,167.63 943.43 1,223.62 1,111.56 1,266.65 1,207.57 2,082.92 1,388.68 1,939.82 1,731.69 1,920.82 946.49 2,370.14 1,716.91 1,426.70 1,745.89
Table S1 page 105/159
EGGSLPPQAR EQAWQRPDGQPATR ESDQGAYTCEAMNAR ESIQASR EVSEAVVDTLESEYLK FDAGSGMATIR FSSGITGCVK FTVTQR GHTPTQPGALNQR GMVFGIPDGVLELVPQR GPSCQDCDTGYTR GSIQVDGEELVSGR GSVYIGGAPDVATLTGGR HCTSSSWSR HQIVGSR HQTHGSLLR IAHVELADAGQYR IESSSPTVVEGQTLDLNCVVAR IQVVVLSASDASPPPVK ITFRPDSADGMLLYNGQK LCNECADGSFHLSTR LDGSLPPDSR LEGDTLIIPR LGTVPQFPR LLQVTPADSGEYVCR LLSGPYFWSLPSR LPAVEPTDQAQYLCR LRSPVISIDPPSSTVQQGQDASFK
LSGSHSQGVAYPVR LVSEDPINDGEWHR LYIFQASPADAGQYVCR LYQASPADSGEYVCR NLVLHSARPGAPPPQPLDLQHR NPDGCLK RGGSLPAR RGSIQVDGEELVSGR RPDGQPATR RVPGSPTNLANR SAEPLALGR SIEYSPQLEDAGSR SIVPQGGSHSLR SLPEVPETIELEVR SPAYTLVWTR SPGPNVAVNAK SPLPWQHR SPVISIDPPSSTVQQGQDASFK TQVHAGR TSTASGLLLWQGVEVGEAGQGK
VAEGQTLDLK VDSYGGSLR VGSSLPGR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
41.3 42.2 74.1 37.6 134.0 85.7 31.7 38.1 49.5 53.5 80.5 70.8 119.0 30.2 30.5 37.7 65.1 108.0 51.7 33.3 31.6 45.2 78.9 53.6 77.3 50.5 94.2 73.1 45.3 71.3 91.1 97.3 36.0 32.4 36.5 59.7 36.8 36.5 34.3 111.0 29.1 90.9 83.2 78.1 35.7 121.0 35.3 111.0 74.3 48.1 58.7
22.0 22.6 10.8 24.7 22.5 21.3 21.6 21.1 23.1 20.7 12.6 22.5 21.9 15.6 19.9 23.6 22.3 21.2 16.4 22.1 18.5 22.1 20.1 22.3 21.6 21.5 22.3 20.6 22.2 21.9 21.9 19.9 18.0 17.8 20.9 22.6 21.6 20.4 20.4 21.7 21.4 20.7 22.1 21.2 23.9 22.8 20.0 21.2 23.4 22.1 22.7
12 3 4 6 25 29 1 3 4 4 2 32 9 1 1 0 5 4 5 0 0 8 26 12 6 6 5 0 5 7 8 9 0 2 1 4 2 2 3 16 0 9 10 22 1 9 1 4 9 8 20
0 0 0 0 0 0 0 0 18 0 0 0 0 0 0 12 4 0 0 1 1 0 0 0 0 0 0 5 2 3 0 0 2 0 0 0 0 0 0 0 2 0 0 0 0 2 0 2 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,011.52 1,639.79 1,702.68 790.41 1,810.90 1,141.53 1,055.52 751.41 1,376.70 1,842.98 1,516.58 1,445.72 1,690.88 1,107.46 796.44 1,048.57 1,442.74 2,374.19 1,706.97 2,042.00 1,766.76 1,056.53 1,126.65 1,014.57 1,707.84 1,522.81 1,760.86 2,557.33 1,457.75 1,666.78 1,958.94 1,715.77 2,413.32 803.37 813.47 1,601.82 997.52 1,281.70 913.51 1,551.73 1,237.67 1,610.86 1,193.63 1,053.57 1,020.54 2,288.14 768.41 2,188.13 1,073.58 953.47 772.43
Table S1 page 106/159
Plasma alpha-L-fucosidase
FUCO2_HUMAN FUCA2
54,050
100.00%
3
3
18
Beta-1,4-galactosyltransferase 1
B4GT1_HUMAN B4GALT1
43,903
100.00%
3
3
19
VISSGSVASYVTSPQGFQFR VPGSPTNLANR VQVSPER VTSYGGELR VTVTSEGGR VVPYFTQTPYSFLPLPTIK YELGSGLAVLR YQLGSGEAR 8.35% FDPTWESLDAR FFNANQWADIFQASGAK YEDFGPLFTAK 14.30% ETMLSDGLNSLTYQVLDVQR LPQLVGVSTPLQGGSNSAAAIGQSSGELR
Protein canopy homolog 2
CNPY2_HUMAN CNPY2
20,635
100.00%
3
3
7
Quinone oxidoreductase PIG3
QORX_HUMAN TP53I3
35,519
100.00%
3
3
4
T-complex protein 1 subunit delta
TCPD_HUMAN CCT4
57,908
100.00%
11
12
23
EH domain-containing protein 2
EHD2_HUMAN EHD2
61,145
100.00%
2
2
4
Secernin-1
SCRN1_HUMAN SCRN1
46,364
100.00%
3
4
9
Isopentenyl-diphosphate Deltaisomerase 1
IDI1_HUMAN IDI1
26,302
100.00%
4
4
12
Neutral alpha-glucosidase AB
GANAB_HUMAN GANAB
106,858
100.00%
23
28
198
VAIIIPFR 25.80% ALVDELEWEIAQVDPK INPDGSQSVVEVPYAR SEAHLTELLEEICDR 11.40% EVAKPSPGEGEVLLK GSLITSLLR MAGAIPLVTAGSQK 27.60% AFADAMEVIPSTLAENAGLNPISTVTELR ALIAGGGAPEIELALR AVADAIR DALSDLALHFLNK IDDVVNTR IGLIQFCLSAPK LVIEEAER TAGINVR TDMDNQIVVSDYAQMDR VIDPATATSVDLR VVSQYSSLLSPMSVNAVMK 4.24% LEGHGLPANLPR LFELEEQDLFR 9.66% AIIESDQEQGR EPAAEIEALLGMDLVR SIFKPFIFVDDVK 23.30% AELGIPLEEVPPEEINYLTR AFSVFLFNTENK IIAATFLFK NVTLNPDPNEIK 26.80% AEKDEPGAWEETFK DENSVELTMAEGPYK DPAEGDGAQPEETPR DPAEGDGAQPEETPRDGDKPEETQGK
FRIDELEPR GLLEFEHQR KLVAIVDPHIK LDLLEDR LKVTEGGEPYR LSFQHDPETSVLVLR LVAIVDPHIK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
105.0 35.8 36.5 43.7 59.1 40.1 96.4 63.7 70.1 102.0 56.2 111.0 37.1 35.5 56.9 66.3 28.7 45.9 44.6 30.1 26.3 64.2 32.9 77.7 36.8 35.8 32.2 36.5 90.8 74.7 63.6 33.8 38.3 55.7 69.1 43.4 59.7 64.8 43.7 52.7 66.5 115.0 109.0 19.8 38.5 59.9 54.8 44.5 49.0 58.0 60.2
22.1 22.9 20.5 21.8 24.2 17.3 20.8 22.8 21.0 21.7 22.1 21.7 19.7 15.8 21.3 21.7 21.8 19.1 17.3 21.5 20.6 17.6 24.0 21.9 23.7 20.8 21.2 24.0 17.9 22.2 22.1 21.9 22.9 22.5 21.5 19.7 20.8 22.3 14.5 22.0 21.8 19.7 19.6 18.0 23.5 21.9 8.5 22.3 22.9 20.7 14.6
13 1 2 6 15 1 25 8 5 5 8 11 0 5 3 2 0 1 2 1 0 3 1 2 2 2 1 2 2 4 2 0 2 4 3 1 4 2 2 4 3 7 6 0 1 6 0 2 2 0 5
0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 2 0 0 0 1 0 0 1 0 0 0 0 0 0 0 2 0 0 1 0 0 0 0 0 3 0 0 0 1 0 7 0 2 26 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,117.07 1,125.60 814.44 981.50 905.47 2,211.21 1,177.66 980.48 1,336.62 1,914.91 1,287.63 2,298.13 2,794.47 928.60 1,854.95 1,730.87 1,814.86 1,552.86 959.59 1,343.74 3,046.54 1,550.89 715.41 1,456.78 931.49 1,346.75 958.52 730.42 2,032.86 1,357.73 2,072.04 1,273.70 1,438.72 1,245.61 1,742.90 1,554.86 2,282.19 1,416.72 1,023.62 1,353.70 1,636.75 1,698.75 1,568.68 2,753.21 1,174.62 1,128.58 1,232.77 873.47 1,248.66 1,740.93 1,104.68
Table S1 page 107/159
MMDYLQGSGETPQTDVR NPEPELLVR QYASLTGTQALPPLFSLGYHQSR
Serine/threonine-protein phosphatase PP2AB_HUMAN PPP2CB 2A catalytic subunit beta isoform
35,557
100.00%
3
3
11
T-complex protein 1 subunit gamma TCPG_HUMAN CCT3
60,517
100.00%
9
9
12
34,796
100.00%
17
20
220
Insulin-like growth factor-binding protein 2
IBP2_HUMAN IGFBP2
REPWLLPSQHNDIIR SGGMERPFVLAR SIRPGLSPYR VPDVLVADPPIAR VSQGSKDPAEGDGAQPEETPR VTEGGEPYR VVIIGAGKPAAVVLQTK WYQMGAYQPFFR YRVPDVLVADPPIAR 11.00% ESNVQEVR SPDTNYLFMGDYVDR YSFLQFDPAPR 17.10% AMTGVEQWPYR AVAQALEVIPR ELGIWEPLAVK GISDLAQHYLMR KVQSGNINAAK TAVETAVLLLR TLIQNCGASTIR VQSGNINAAK WSSLACNIALDAVK 69.20% CPPCTPER CYPHPGSELPLQALVMGEGTCEK DAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGR
EKVTEQHR GDPECHLFYNEQQEAR GECWCVNPNTGK GPLEHLYSLHIPNCDK HGLYNLK HHLGLEEPK HHLGLEEPKK LAACGPPPVAPPAAVAAVAGGAR
Matrix metalloproteinase-9
MMP9_HUMAN MMP9
78,442
100.00%
11
11
45
LEGEACGVYTPR LIQGAPTIR MPCAELVR MSLNGQR SGMKELAVFR TPCQQELDQVLER 19.70% AFALWSAVTPLTFTR AVIDDAFAR FQTFEGDLK FTEGPPLHKDDVNGIR GSRPQGPFLIADKWPALPR LFGFCPTR LGLGADVAQVTGALR QLAEEYLYR QLSLPETGELDSATLK QSTLVLFPGDLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
110.0 46.4 69.6 38.7 39.8 35.9 41.8 93.9 42.2 66.8 38.7 43.3 44.6 69.6 64.7 38.8 72.6 40.5 41.1 49.2 84.3 45.9 34.3 71.5 34.4 58.7 22.5 56.3 67.0 71.0 30.8 39.8 51.1 30.3 107.0 85.4 43.7 50.5 36.9 44.2 108.0 65.4 42.8 31.6 32.9 44.3 42.5 110.0 42.3 65.6 74.0
17.3 20.7 20.2 20.5 23.0 21.7 17.0 20.8 21.9 3.0 19.8 17.4 22.5 20.2 21.8 21.3 16.3 19.1 22.9 21.6 15.8 23.4 23.0 22.8 16.8 20.3 14.1 22.0 15.9 15.3 22.1 22.7 22.2 23.0 19.3 21.6 15.7 21.6 22.8 23.2 21.4 20.6 23.5 22.1 22.5 17.5 21.6 18.9 20.8 21.9 21.0
18 6 0 0 0 1 2 6 13 5 1 0 3 4 4 1 2 1 1 1 2 2 1 1 1 0 0 6 2 8 0 20 1 0 41 21 31 8 4 0 12 2 2 1 0 0 2 8 2 4 6
0 0 14 4 4 0 0 36 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 4 0 1 0 48 1 4 0 0 0 0 4 0 0 0 0 2 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,959.84 1,066.59 2,535.30 1,874.00 1,335.68 1,145.64 1,361.78 2,154.99 1,007.48 1,664.05 1,609.73 1,680.94 960.48 1,792.79 1,340.66 1,353.63 1,166.69 1,254.71 1,419.71 1,129.63 1,185.72 1,333.69 1,001.54 1,547.79 1,016.43 2,589.18 4,318.81 1,026.53 1,992.85 1,421.59 1,892.93 844.47 1,059.56 1,187.65 2,041.10 1,351.63 968.59 975.48 805.40 1,153.60 1,615.78 1,680.91 977.51 1,084.53 1,794.91 2,106.16 997.49 1,440.82 1,184.60 1,701.89 1,345.75
Table S1 page 108/159
LDLR chaperone MESD
MESD_HUMAN MESDC2
Glutathione reductase, mitochondrial GSHR_HUMAN GSR
26,060
100.00%
5
5
8
56,239
100.00%
8
9
51
Isocitrate dehydrogenase [NADP] cytoplasmic
IDHC_HUMAN IDH1
46,643
100.00%
18
20
114
Quinone oxidoreductase
QOR_HUMAN CRYZ
35,189
100.00%
6
6
20
SLGPALLLLQK 27.80% DYNDADMAR IDPSKPESILK LLEQWEKDDDIEEGDLPEHK RPSAPVDFSK TLMMFVTVSGSPTEK 23.00% ADFDNTVAIHPTSSEELVTLR ALLTPVAIAAGR GHAAFTSDPKPTIEVSGK LGGTCVNVGCVPK LGIQTDDKGHIIVDEFQNTNVK LNAIYQNNLTK RAAELGAR TYSTSFTPMYHAVTK 50.50% ATDFVVPGPGK DAAEAIKK DATNDQVTK FKDIFQEIYDK GQETSTNPIASIFAWTR GWPLYLSTK IIWELIK ISGGSVVEMQGDEMTR KISGGSVVEMQGDEMTR LIDDMVAQAMK LVSGWVKPIIIGR NILGGTVFR SDYLNTFEFMDK SEGGFIWACK SIEDFAHSSFQMALSK TVEAEAAHGTVTR VEITYTPSDGTQK VTYLVHNFEEGGGVAMGMYNQDK
27.40% ILGTAGTEEGQK KPLLPYTPGSDVAGVIEAVGDNASAFK
Desmoplakin
DESP_HUMAN DSP
331,763
100.00%
28
29
115
QGAAIGIPYFTAYR SDIAVPIPK VAEAHENIIHGSGATGK VFEFGGPEVLK 11.60% AELIVQPELK AESGPDLR AFIGFEGVK ALLQAILQTEDMLK ANSSATETINK ATGSEVSQR FGDSNTVMR FLEFQYLTGGLVDPEVHGR GFFDPNTEENLTYLQLK GIVDSITGQR GYFNEELSEILSDPSDDTK IEVLEEELR ISITEGIER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
80.3 42.3 43.6 36.7 44.7 38.5 66.1 74.6 30.8 53.0 43.0 55.9 56.2 58.8 64.4 37.5 40.0 52.0 97.2 47.1 30.7 98.6 38.4 57.0 58.9 54.8 81.6 48.1 40.6 76.1 63.4 63.1 53.0 33.1 52.7 41.5 79.1 47.1 52.9 35.3 36.0 72.7 51.2 44.0 49.8 47.8 76.7 45.6 67.5 51.7 33.5
11.5 13.2 19.1 21.8 23.5 21.6 21.6 14.0 21.4 22.8 20.6 21.8 21.5 21.8 23.2 23.4 21.8 22.8 23.0 22.3 20.2 18.8 21.3 22.5 12.3 20.8 17.2 20.5 21.6 22.7 23.0 18.6 23.5 19.5 21.0 14.8 22.3 22.9 16.8 19.4 21.5 19.9 23.4 23.6 18.8 21.6 22.5 22.7 20.3 23.7 23.0
12 1 2 0 2 1 1 20 0 2 0 6 3 4 5 2 1 6 27 4 2 6 0 5 2 5 10 2 2 10 8 0 4 0 4 4 2 4 4 1 2 12 2 1 4 0 8 4 2 4 1
0 0 0 2 0 0 9 0 1 0 5 0 0 0 0 0 0 6 0 0 0 0 2 0 3 0 0 0 0 0 0 6 0 2 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,152.74 1,086.42 1,226.70 2,438.14 1,103.59 1,659.80 2,315.15 1,152.71 1,841.94 1,360.67 2,484.27 1,291.70 843.48 1,733.82 1,087.58 845.47 991.47 1,445.73 1,878.94 1,064.58 914.57 1,727.76 1,855.85 1,266.61 1,437.89 976.56 1,525.65 1,154.53 1,813.84 1,341.68 1,438.71 2,591.15 1,203.62 2,716.42 1,527.80 939.55 1,690.85 1,221.65 1,139.67 844.42 967.53 1,586.88 1,135.56 934.46 1,042.46 2,177.10 2,028.99 1,045.56 2,158.97 1,129.61 1,017.56
Table S1 page 109/159
Protein RCC2
RCC2_HUMAN RCC2
56,067
100.00%
8
11
42
Vinculin
VINC_HUMAN VCL
123,783
100.00%
45
48
212
ITNLTQQLEQASIVK LSLQDAVSQGVIDQDMATR NQCTQVVQER QAELDGK QLQNIIQATSR RVEEDIQQQK SAIYQLEEEYENLLK SGSLSLTQFADMISLK SMVEDITGLR STLEAETR SVQNDSQAIAEVLNQLK TLELQGLINDLQR VTQLTDR YEVTSGGGGTSR YGDGIQLTR 14.20% AGGAAVVITEPEHTK AGGAAVVITEPEHTKER DGQILPVPNVVVR LFDFPGR LGHAEQKDEMVPR RVEAPR VFSWGFGGYGR VKLEGSK 47.90% AAAVGTANK AGEVINQPMMMAAR AIPDLTAPVAAVQAAVSNLVR ALASIDSK ALASQLQDSLK AQQVSQGLDVLTAK AVAGNISDPGLQK AVANSRPAK DPSASPGDAGEQAIR EAEAASIK EAFQPQEPDFPPPPPDLEQLR ELLPVLISAMK ELTPQVVSAAR ETVQTTEDQILK ETVQTTEDQILKR EVENSEDPK EVENSEDPKFR GEGESPQAR GQGSSPVAMQK GVGQAAIR GWLRDPSASPGDAGEQAIR IPTISTQLK KIDAAQNWLADPNGGPEGEEQIR
LANVMMGPYR LLAVAATAPPDAPNREEVFDER LVQAAQMLQSDPYSVPAR MALLMAEMSR MLGQMTDQVADLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
72.9 78.6 43.1 30.4 63.8 34.8 69.2 53.3 34.2 36.1 99.2 71.1 30.2 59.5 46.2 57.1 50.7 60.8 37.0 42.9 38.9 38.9 41.0 46.4 56.1 103.0 31.7 66.3 102.0 76.8 61.8 84.5 46.5 79.6 59.6 40.6 55.6 67.7 32.5 43.2 47.5 55.4 55.5 36.3 42.5 69.9 62.5 47.1 88.1 76.8 88.2
17.3 22.4 21.7 22.6 22.2 22.7 21.8 22.5 22.9 24.1 21.0 20.1 24.9 21.1 22.2 22.1 21.2 15.9 21.7 22.6 19.6 21.7 20.5 25.2 20.5 13.4 25.0 22.9 21.6 21.1 20.1 20.9 24.2 21.6 18.7 21.6 23.1 22.3 18.0 21.8 18.6 22.8 18.9 22.2 19.3 21.4 21.3 21.2 21.7 22.5 21.8
1 1 15 1 13 2 6 2 3 4 7 3 1 5 2 6 0 7 4 1 3 2 3 1 10 8 2 12 11 10 2 9 1 4 12 2 2 2 1 2 1 4 4 1 2 0 2 0 4 4 5
0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 5 5 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 0 10 1 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,685.94 2,063.01 1,261.60 760.38 1,271.71 1,272.66 1,841.92 1,713.87 1,136.56 906.45 1,856.97 1,512.84 832.45 1,170.54 1,022.53 1,479.78 1,764.92 1,405.82 851.44 1,525.74 727.42 1,232.59 760.46 802.44 1,566.71 2,076.18 804.45 1,173.65 1,457.80 1,269.68 913.52 1,470.68 818.43 2,447.19 1,213.72 1,170.65 1,404.72 1,560.82 1,046.46 1,349.63 930.43 1,089.54 771.45 1,982.97 1,000.60 2,508.21 1,183.56 2,381.21 1,990.01 1,152.56 1,509.70
Table S1 page 110/159
MQEAMTQEVSDVFSDTTTPIK MSAEINEIIR MTGLVDEAIDTK NPGNQAAYEHFETMK NQGIEEALK NQGIEEALKNR QVATALQNLQTK SFLDSGYR SLGEISALTSK STVEGIQASVK TNISDEESEQATEMLVHNAQNLMQSVK
Semaphorin-3A
SEM3A_HUMAN SEMA3A
88,873
100.00%
3
3
6
Heat shock 70 kDa protein 1A/1B
HSP71_HUMAN HSPA1A
70,036
100.00%
29
40
520
TNLLQVCER VAMANIQPQMLVAGATSIAR VDQLTAQLADLAAR VLQLTSWDEDAWASK VMLVNSMNTVK WIDNPTVDDR 5.58% DGPNYQWVPYQGR DLPDDVITFAR QQQLYIGSTAGVAQLPLHR 54.40% AEDEVQR AFYPEEISSMVLTK AQIHDLVLVGGSTR ARFEELCSDLFR ATAGDTHLGGEDFDNR CQEVISWLDANTLAEKDEFEHK DAGVIAGLNVLR ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK
FEELCSDLFR FGDPVVQSDMK HWPFQVINDGDKPK IINEPTAAAIAYGLDR ITITNDKGR KFGDPVVQSDMK LDKAQIHDLVLVGGSTR LLQDFFNGR LSKEEIER LVNHFVEEFK LVNHFVEEFKR MVQEAEK MVQEAEKYK NALESYAFNMK NQVALNPQNTVFDAK NQVALNPQNTVFDAKR NSTIPTK QTQIFTTYSDNQPGVLIQVYEGER
SAVEDEGLK SAVEDEGLKGK SINPDEAVAYGAAVQAAILMGDK
STLEPVEK TTPSYVAFTDTER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
133.0 53.6 73.7 59.5 37.8 27.5 81.0 39.7 63.7 78.4 77.7 46.5 155.0 46.4 73.7 51.2 51.0 71.6 63.8 28.8 32.6 93.3 92.0 42.6 80.2 18.5 93.0 92.6 49.7 73.9 50.8 122.0 64.4 44.4 21.4 57.6 55.0 41.3 42.2 49.8 32.2 82.7 108.0 64.5 33.7 46.3 39.1 41.2 135.0 36.5 106.0
20.0 24.0 23.2 21.4 21.2 21.1 21.5 19.5 22.4 22.5 17.8 23.8 19.8 21.2 22.7 22.7 20.3 20.8 23.2 19.1 19.3 22.3 19.9 21.5 18.3 21.0 18.3 20.1 20.0 21.4 22.5 21.0 22.3 22.8 17.6 22.5 22.9 23.1 22.6 23.2 23.3 20.3 22.0 21.8 25.0 21.1 22.6 23.9 21.3 22.2 21.6
4 4 6 1 3 0 11 3 6 2 0 2 5 2 6 5 2 2 3 0 1 35 25 2 16 0 46 0 7 10 1 62 20 4 0 21 12 6 2 3 3 14 37 2 4 2 2 1 17 1 97
0 0 0 0 0 1 0 0 0 0 11 0 6 0 0 0 0 0 0 1 0 0 3 1 24 0 0 7 0 0 58 19 0 0 0 0 0 5 10 0 0 0 0 1 0 3 0 0 3 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,358.08 1,191.60 1,292.64 1,736.77 1,001.53 1,271.67 1,314.74 944.45 1,105.61 1,118.61 3,078.40 1,132.58 2,058.08 1,484.81 1,748.85 1,235.65 1,230.58 1,579.73 1,261.64 2,080.13 846.40 1,630.80 1,465.81 1,542.74 1,675.73 2,662.25 1,197.70 3,055.50 1,315.60 1,238.57 1,680.85 1,687.90 1,017.57 1,350.67 1,822.02 1,109.57 1,003.54 1,261.66 1,417.76 834.40 1,125.56 1,287.60 1,658.85 1,814.95 760.42 2,786.36 947.47 1,132.59 2,320.15 902.48 1,487.70
Table S1 page 111/159
SH3 domain-binding glutamic acid- SH3L3_HUMAN SH3BGRL3 rich-like protein 3
10,420
100.00%
4
5
31
39.80%
VEIIANDQGNR VQVSYK YKAEDEVQR IQYQLVDISQDNALR IQYQLVDISQDNALRDEMR SQQSEVTR VYSTSVTGSR DAEEAISQTIDTIVDMIK GDEGPPGSEGAR GDPGEAGPQGDQGR GDPGFEGER GLEQLLVGGSHLK IALVITDGR LKPYGALVDK LLLFSDGNSQGATPAAIEK NVQELK TAEYDVAYGESHLFR TDPAHDVR VAVVQYSGTGQQRPER VFSVAITPDHLEPR VPSYQALLR LDFLIPLSK NTPSPFIETFTEDDEASR VVINVPIFK ILELDQFK IMATPEQVGK NIPPYFVALVPQEEELDDQK NIYVLQELDNPGAK SDSFENPVLQQHFR TFNTSTGGLLLPSDTKR
Collagen alpha-1(VI) chain
CO6A1_HUMAN COL6A1
108,513
100.00%
14
17
66
16.70%
Glutamate--cysteine ligase catalytic subunit
GSH1_HUMAN GCLC
72,750
100.00%
3
3
4
5.65%
X-ray repair cross-complementing protein 6
XRCC6_HUMAN XRCC6
69,828
100.00%
6
6
11
13.60%
Calpain small subunit 1
CPNS1_HUMAN CAPNS1
28,299
100.00%
4
5
9
Xaa-Pro aminopeptidase 1
XPP1_HUMAN XPNPEP1
69,901
100.00%
2
2
4
Proteasome subunit beta type-3
PSB3_HUMAN PSMB3
22,932
100.00%
7
10
46
Laminin subunit gamma-2
LAMC2_HUMAN LAMC2
130,958
100.00%
23
24
286
23.10% LFAQLAGDDMEVSATELMNILNK LGFEEFK SMVAVMDSDTTGK YSDESGNMDFDNFISCLVR 5.14% GSLTFEPLTLVPIQTK QEALEWLIR VTSELLR 47.80% DAVSGMGVIVHIIEK FGIQAQMVTTDFQK FGPYYTEPVIAGLDPK LNLYELK LYIGLAGLATDVQTVAQR NCVAIAADRR QIKPYTLMSMVANLLYEK 24.60% ADSLSSLVTR AGYFGDPLAPNPADK ALGSAAADAQR ALHEGVGSGSGSPDGAVVQGLVEK
AQGGDGVVPDTELEGR CLNCNDNTDGIHCEK CVCKPAVTGER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
80.0 30.9 50.8 104.0 58.8 45.0 76.8 67.3 68.0 65.3 30.8 46.0 47.8 30.4 88.5 30.1 65.2 32.2 48.9 47.8 54.8 35.9 109.0 56.4 33.2 37.6 34.0 90.9 34.0 58.9 140.0 42.9 47.7 107.0 45.3 43.1 33.9 64.8 87.6 71.2 42.7 102.0 41.6 42.5 63.5 72.7 89.0 73.5 81.4 54.1 36.6
22.6 21.0 23.2 21.4 22.4 23.6 21.7 22.0 21.6 18.6 20.0 18.1 20.0 18.4 22.7 22.9 20.8 21.8 21.8 21.1 21.9 16.8 19.0 14.6 20.3 24.4 22.3 22.1 22.2 21.2 21.0 20.5 16.9 15.2 17.9 21.8 22.3 22.4 22.5 21.5 19.6 16.2 23.2 20.9 23.6 22.5 22.8 21.7 22.0 11.8 22.5
56 1 28 2 4 7 10 2 3 6 1 2 2 0 12 2 2 2 3 3 12 1 2 1 1 2 2 2 0 1 2 1 1 3 2 2 1 2 9 9 6 12 1 0 11 14 63 0 18 1 0
0 0 25 0 8 0 0 0 0 0 0 3 0 1 0 0 3 0 7 0 0 0 0 0 0 0 0 0 3 0 2 0 0 0 0 0 0 0 0 1 0 4 1 1 0 0 0 6 0 0 7
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,228.63 723.40 1,137.55 1,775.93 2,307.14 934.46 1,056.53 2,007.98 1,128.49 1,340.58 963.42 1,350.77 957.57 1,103.65 1,932.01 730.41 1,757.81 910.44 1,774.92 1,580.84 1,046.60 1,045.63 2,055.91 1,028.65 1,005.56 1,089.56 2,344.17 1,573.82 1,703.81 1,807.96 2,523.25 869.44 1,373.59 2,268.95 1,743.99 1,157.63 817.48 1,583.85 1,629.79 1,766.90 892.51 1,889.05 1,145.58 2,174.12 1,048.56 1,532.74 1,030.53 2,250.14 1,599.76 1,849.73 1,276.61
Table S1 page 112/159
Spliceosome RNA helicase BAT1
UAP56_HUMAN BAT1
48,974
100.00%
9
9
33
22.90%
High mobility group protein HMGI/HMG-Y 3-ketoacyl-CoA thiolase, mitochondrial Tissue factor pathway inhibitor
HMGA1_HUMAN HMGA1
11,658
100.00%
2
2
4
22.40%
THIM_HUMAN ACAA2
41,906
100.00%
2
2
3
7.81%
TFPI1_HUMAN TFPI
34,998
100.00%
2
2
5
5.59%
DNA damage-binding protein 2
DDB2_HUMAN DDB2
47,847
100.00%
2
2
3
4.22%
Guanine nucleotide-binding protein subunit beta-2-like 1
GBLP_HUMAN GNB2L1
35,059
100.00%
10
11
40
34.70%
Lactotransferrin
TRFL_HUMAN LTF
78,164
100.00%
2
2
13
2.96%
Galectin-3-binding protein
LG3BP_HUMAN LGALS3BP
65,314
100.00%
24
32
2361
47.40%
EATQAEIEADR EFDLQVDNR ELEFDTNMDAVQMVITEAQK EVEGELER HPSAHDVILEGAGLR HQDVFSSAQR IQMDQFMQQLQR ITSTFHQDVDGWK LAESHVESASNMEQLTR LDPVYFVAPAK MQQAEQALQDILR NLGNWKEEAQQLLQNGK QCIFDR SLAQEATR SSAEYSVHK VSDASDKTQQAER DFLLKPELLR DVQEIFR ELAFQISK FMQDPMEIFVDDETK GLAITFVSDENDAK ILVATNLFGR LTLHGLQQYYVK QVMMFSATLSK VAVFFGGLSIK KQPPVSPGTALVGSQK SSQPLASK AANDAGYFNDEMAPIEVK DFTATDLSEFAAK FFFNIFTR FYYNSVIGK ASFLYSLPHR YNLIVVGR DETNYGIPQR DGQAMLWDLNEGK DVLSVAFSSDNR FSPNSSNPIIVSCGWDK IIVDELKQEVISTSSK LTRDETNYGIPQR LWDLTTGTTTR LWNTLGVCK QIVSGSR YWLCAATGPSIK CGLVPVLAENYK YYGYTGAFR AAFGQGSGPIMLDEVQCTGTEASLADCK
ASHEEVEGLVEK AVDTWSWGER ELSEALGQIFDSQR GLNLTEDTYKPR GQWGTVCDNLWDLTDASVVCR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
62.2 55.6 65.9 40.5 51.3 66.0 83.1 73.1 84.9 71.5 99.2 39.2 31.8 67.2 49.4 78.8 32.5 34.4 37.0 92.6 45.1 79.9 26.4 49.4 42.5 57.4 51.6 78.8 40.6 39.7 38.2 29.1 64.3 52.6 92.9 79.2 49.3 118.0 46.6 55.0 51.4 38.3 44.1 63.3 42.4 49.5 65.9 81.0 125.0 55.4 122.0
20.6 22.2 19.5 21.6 21.3 21.6 22.6 22.6 22.3 21.2 23.0 21.0 22.1 24.5 21.9 21.7 16.1 24.2 20.9 18.3 22.8 17.7 20.0 21.6 16.5 17.8 24.1 19.0 21.4 24.0 24.0 23.3 19.6 22.2 20.8 22.1 20.7 18.1 22.7 22.7 24.2 24.2 22.3 22.2 21.7 19.3 22.9 19.6 22.8 22.9 19.7
3 5 1 2 0 21 28 4 7 13 16 0 2 10 3 4 1 3 2 5 2 10 0 4 5 2 2 2 1 2 3 0 2 5 6 6 2 6 2 6 2 1 2 6 7 0 93 353 314 2 8
0 0 0 0 25 0 0 0 18 0 0 4 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 0 0 0 0 0 0 0 7 78 0 37 3 2
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,232.58 1,135.54 2,344.07 960.46 1,571.83 1,174.56 1,565.76 1,533.73 1,901.90 1,219.67 1,559.79 1,970.01 838.39 875.46 1,007.48 1,434.68 1,243.74 906.47 935.52 1,844.81 1,479.73 1,103.66 1,462.81 1,258.62 1,137.67 1,593.90 817.44 1,970.88 1,415.67 1,091.57 1,090.56 1,190.63 933.55 1,192.56 1,492.67 1,309.64 1,907.90 1,789.00 1,562.79 1,264.65 1,090.57 746.42 1,366.68 1,362.71 1,097.51 2,913.31 1,326.65 1,206.55 1,592.79 1,406.73 2,452.10
Table S1 page 113/159
Glutamate dehydrogenase 1, mitochondrial
DHE3_HUMAN GLUD1
61,382
100.00%
14
18
51
30.10%
Pre-mRNA-processing factor 19
PRP19_HUMAN PRPF19
55,163
100.00%
4
4
7
12.30%
Splicing factor U2AF 65 kDa subunit Heterogeneous nuclear ribonucleoprotein R
U2AF2_HUMAN U2AF2
53,483
100.00%
2
2
12
5.47%
HNRPR_HUMAN HNRNPR
70,926
100.00%
3
3
19
11.20%
PSB4_HUMAN PSMB4
29,187
100.00%
8
9
54
48.50%
Proteasome subunit beta type-4
IDITLSSVK IYTSPTWSAFVTDSSWSAR KSQLVYQSR KTLQALEFHTVPFQLLAR LADGGATNQGR LASAYGAR RIDITLSSVK SDLAVPSELALLK SLGWLK SQLVYQSR STHTLDLSR STSSFPCPAGHFNGFR TIAYENK TLQALEFHTVPFQLLAR TVIRPFYLTNSSGVD VEIFYR YSSDYFQAPSDYR YYPYQSFQTPQHPSFLFQDK ALASLMTYK DDGSWEVIEGYR DIVHSGLAYTMER DSNYHLLMSVQESLER GASIVEDK GASIVEDKLVEDLR GFIGPGIDVPAPDMSTGER HGGTIPIVPTAEFQDR IIAEGANGPTTPEADKIFLER LQHGSILGFPK MVEGFFDR TAAYVNAIEK YNLGLDLR YSTDVSVDEVK IWSVPNASCVQVVR SSEQILATLK TVPEELVKPEELSK YIAENGTDPINNQPLSEEQLIDIK ELLTSFGPLK LFIGGLPNYLNDDQVK AGPIWDLR DLYEDELVPLFEK EAAQEAVK NLATTVTEEILEK TGYTLDVTTGQR VTEGLVDVILYHQPDDK AIHSWLTR FEGGVVIAADMLGSYGSLAR FQIATVTEK GVEIEGPLSTETNWDIAHMISGFE
QPVLSQTEAR QVLGQMVIDEELLGDGHSYSPR
TQNPMVTGTSVLGVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
65.7 145.0 57.8 33.3 95.2 61.8 51.0 90.9 45.3 58.7 43.9 48.6 42.7 87.8 51.7 35.5 105.0 58.5 45.8 79.8 57.7 54.1 44.4 71.7 68.8 59.7 93.0 34.7 53.6 44.2 65.0 77.3 48.4 47.0 56.4 46.0 50.6 53.5 39.9 43.1 37.7 81.0 43.9 34.8 40.8 83.1 45.8 71.0 57.0 94.5 89.8
19.2 21.4 20.0 14.3 20.7 23.0 16.6 18.8 24.7 21.4 21.4 20.1 22.7 17.5 21.0 21.1 17.6 21.6 20.8 20.3 21.6 21.7 24.2 21.9 22.6 21.5 20.8 19.0 18.1 21.7 23.1 21.8 21.7 22.2 20.5 21.0 21.3 21.6 21.3 21.7 22.0 22.1 22.5 21.7 19.6 22.5 20.5 20.0 22.0 21.3 22.1
37 139 58 0 110 78 88 132 74 91 26 6 13 98 2 23 304 5 5 4 4 2 1 2 4 2 2 1 5 4 3 4 2 2 2 1 7 5 2 4 5 14 2 0 2 8 6 2 6 2 9
0 10 13 0 0 0 0 0 0 0 0 0 0 116 0 0 0 19 0 0 1 0 0 3 0 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 13 0
0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
975.57 2,162.02 1,108.61 2,112.20 1,059.52 808.43 1,131.67 1,355.78 703.41 980.52 1,029.53 1,768.79 838.43 1,984.10 1,668.86 826.45 1,598.68 2,521.18 1,013.53 1,425.63 1,507.72 1,936.91 818.43 1,543.83 1,931.92 1,737.89 2,242.17 1,196.68 1,016.45 1,079.57 963.53 1,241.59 1,614.84 1,089.62 1,597.87 2,714.35 1,104.63 1,805.94 927.51 1,609.80 845.44 1,460.79 1,311.65 1,941.00 983.54 2,029.01 1,036.57 2,648.22 1,128.60 2,459.19 1,547.81
Table S1 page 114/159
Polypeptide Nacetylgalactosaminyltransferase 5
GALT5_HUMAN GALNT5
106,250
100.00%
3
3
11
Fructose-bisphosphate aldolase C
ALDOC_HUMAN ALDOC
39,438
100.00%
9
13
100
VNNSTMLGASGDYADFQYLK 3.51% ALLPEDSGTHQVLR NDNPYSFPK VEVDLDQTQR 46.40% ALQASALNAWR DGADFAK DNAGAATEEFIKR GILAADESVGSMAK GVVPLAGTDGETTTQGLDGLSER
KDGADFAK QVLFSADDR TPSALAILENANVLAR VDKGVVPLAGTDGETTTQGLDGLSER
VLAAVYK YASICQQNGIVPIVEPEILPDGDHDLK YASICQQNGIVPIVEPEILPDGDHDLKR
YEGSGEDGGAAAQSLYIANHAY
Heat shock 70 kDa protein 4
HSP74_HUMAN HSPA4
94,314
100.00%
32
35
178
YTPEEIAMATVTALR 48.50% AESEEMETSQAGSK AFSDPFVEAEK AGGIETIANEYSDR EFSITDVVPYPISLR ELSTTLNADEAVTR EMLNLYIENEGK FLEMCNDLLAR FQESEERPK GCALQCAILSPAFK LEDTENWLYEDGEDQPK LFEELGK LKETAESVLK LMNETTAVALAYGIYK LNLQNK MDQPPQAK MQVDQEEPHVEEQQQQTPAENK MQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSK
NAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDK
Tissue alpha-L-fucosidase
FUCO_HUMAN FUCA1
53,672
100.00%
5
5
24
NAVEEYVYEMR NFTTEQVTAMLLSK NKEDQYDHLDAADMTK QDLPALEEKPR QIQQYMK QSLTMDPVVK SEENEEPMETDQNAK SEENEEPMETDQNAKEEEK SNLAYDIVQLPTGLTGIK STNEAMEWMNNK SVMDATQIAGLNCLR TSTVDLPIENQLLWQIDR VEPPKEEQK VLATAFDTTLGGR 14.20% DGLIVPIFQER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
108.0 71.7 41.2 37.6 66.2 46.1 69.4 86.2 129.0 55.0 57.3 93.2 84.6 45.5 68.3 91.7 114.0 64.9 117.0 51.8 69.1 65.0 78.3 62.1 49.5 44.0 37.1 95.2 30.8 40.5 96.9 33.4 47.6 70.2 42.8 46.1 66.4 88.8 31.3 66.0 33.5 41.8 60.7 34.1 135.0 74.1 88.4 94.1 31.8 114.0 41.2
21.3 21.8 20.5 22.4 22.7 22.6 23.1 22.6 21.5 22.3 23.3 17.1 20.8 18.0 21.0 19.7 19.2 22.9 16.4 21.5 22.0 20.7 23.2 22.3 20.9 22.8 22.6 16.9 20.2 21.0 22.0 23.3 19.4 19.1 13.0 16.3 18.3 21.9 20.2 21.0 21.5 23.0 12.3 13.8 17.2 17.0 22.9 20.6 20.7 21.7 21.6
6 4 4 3 2 14 2 4 46 4 4 12 2 18 0 0 2 3 2 11 13 16 10 2 2 8 1 6 1 3 3 2 4 0 0 0 5 10 0 3 1 3 1 0 25 6 4 4 1 11 2
0 0 0 0 0 0 0 0 9 0 0 2 11 0 5 5 0 1 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 2 0 2 0 0 2 2 0 0 0 1 1 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,210.01 1,535.82 1,081.50 1,202.60 1,200.65 723.33 1,421.70 1,364.67 2,273.13 851.43 1,050.52 1,652.93 2,615.32 763.47 3,020.50 3,176.61 2,243.98 1,681.85 1,483.62 1,239.59 1,495.70 1,735.93 1,519.76 1,452.70 1,397.66 1,149.55 1,535.77 2,080.90 835.46 1,117.65 1,773.91 729.43 930.44 2,638.17 4,118.77 3,366.46 1,418.63 1,582.82 1,893.83 1,295.70 954.47 1,117.59 1,766.70 2,281.93 1,903.05 1,454.60 1,664.81 2,141.12 1,083.57 1,321.71 1,286.71
Table S1 page 115/159
ERO1-like protein alpha
ERO1A_HUMAN ERO1L
54,377
100.00%
7
7
22
18.20%
Glycylpeptide Ntetradecanoyltransferase 1
NMT1_HUMAN NMT1
56,789
100.00%
6
6
13
16.50%
Glycyl-tRNA synthetase
SYG_HUMAN GARS
83,124
100.00%
9
9
20
16.10%
RuvB-like 2
RUVB2_HUMAN RUVBL2
51,140
100.00%
8
8
20
21.00%
40,212
100.00%
6
6
10
25.60%
Vesicular integral-membrane protein LMAN2_HUMAN LMAN2 VIP36
DLVGELGTALR DNYPPGFSYADFGPQFTAR FFHPEEWADLFQAAGAK TQHFVSAK FDGILTEGEGPR LGAVDESLSEETQK LIANMPESGPSYEFHLTR LLESDYFR LQTQGLGTALK QEIVSLFNAFGR YLLQETWLEK AIELFSVGQGPAK DIPVVHQLLTR GFDVFNALDLMENK GSETDSAQDQPVK LGEVVNTHGPVEPDKDNIR SYQFWDTQPVPK APQVDVDK GEFTIETEGK LGDAVEQGVINNTVLGYFIGR LPFAAAQIGNSFR QQGDLVR SPITGNDLSPPVSFNLMFK TLYVEEVVPNVIEPSFGLGR TVNVVQFEPSK VDDSSGSIGR AAGVVLEMIR AVLIAGQPGTGK GLGLDDALEPR LLIVSTTPYSEK QASQGMVGQLAAR TQGFLALFSGDTGEIK TTEMETIYDLGTK VYSLFLDESR DRLVPGPVFGSK LFQLMVEHTPDEESIDWTK LPTGYYFGASAGTGDLSDNHDIISMK
Endoplasmic reticulum aminopeptidase 2
ERAP2_HUMAN ERAP2
110,449
100.00%
9
9
17
ATP-dependent RNA helicase A
DHX9_HUMAN DHX9
140,944
100.00%
9
9
22
NCIDITGVR NLHGDGIALWYTR WTELAGCTADFR 10.60% AAELFSQWMESSGK FDLGSYDIR FPWQELR ILAVTDFEPTQAR LIELGMEGK TQNLAALLHAIAR VLSYPAHEQIALLVPEK VSIYASPDKR YFDIYYPLSK 9.45% AIEPPPLDAVIEAEHTLR DFVNYLVR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0%
81.9 94.9 28.5 37.3 62.5 91.0 38.9 41.9 41.1 88.1 40.7 58.9 32.2 55.9 32.5 48.8 48.8 51.0 40.3 77.5 73.9 36.5 32.3 65.3 56.8 68.9 57.9 63.3 73.6 64.2 51.9 95.3 74.2 45.2 32.0 31.8 48.7 32.5 30.5 86.3 69.6 50.2 34.5 70.9 33.2 60.0 40.9 30.1 39.5 27.5 39.3
23.1 18.8 22.7 23.5 22.0 23.1 22.8 21.9 20.4 22.2 22.0 22.0 18.1 22.1 19.6 21.8 22.1 20.1 22.1 19.2 21.9 21.5 22.2 19.2 22.5 22.2 22.3 17.6 21.5 19.9 23.0 21.3 22.1 22.8 21.7 21.4 19.3 23.0 22.4 20.5 20.0 22.0 23.4 22.5 23.7 15.7 17.4 22.5 23.1 19.8 22.3
13 7 0 1 2 2 0 2 2 10 2 2 3 1 2 0 3 2 2 2 4 1 2 1 4 2 2 2 2 2 2 4 4 2 0 0 0 1 1 3 2 2 1 5 1 2 1 1 2 0 2
0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 2 0 0 0 0 0 0 0 0 0 0 0 0 1 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,143.64 2,149.96 1,963.93 917.48 1,290.63 1,505.73 2,078.00 1,042.52 1,129.66 1,380.73 1,322.70 1,316.72 1,290.75 1,612.77 1,361.62 2,089.07 1,495.72 871.45 1,110.53 2,235.18 1,391.74 815.44 2,064.05 2,218.18 1,247.66 992.47 1,058.60 1,111.65 1,155.60 1,350.75 1,332.67 1,683.86 1,501.71 1,228.62 1,271.71 2,334.10 2,746.27 1,047.53 1,515.77 1,426.64 1,570.72 1,085.53 975.51 1,460.78 989.53 1,391.81 1,907.06 1,135.61 1,308.65 1,971.06 1,025.54
Table S1 page 116/159
26,671
100.00%
7
7
18
CEAM6_HUMAN CEACAM6
37,177
99.50%
2
3
22
PSMD1_HUMAN PSMD1
105,821
100.00%
5
5
12
APLP2_HUMAN APLP2
86,937
100.00%
17
24
499
40S ribosomal protein S3
RS3_HUMAN
Carcinoembryonic antigen-related cell adhesion molecule 6 26S proteasome non-ATPase regulatory subunit 1
Amyloid-like protein 2
RPS3
DVVQAYPEVR ELDALDANDELTPLGR GMTLVTPLQLLLFASK LGGIGQFLAK QPAIISQLDPVNER TTQVPQFILDDFIQNDR YPSPFFVFGEK 35.40% DEILPTTPISEQK ELAEDGYSGVEVR FGFPEGSVELYAEK GGKPEPPAMPQPVPTA KPLPDHVSIVEPK LLGGLAVR TEIIILATR 9.88% EVLLLAHNLPQNR SDPVTLNVLYGPDGPTISPSK 9.13% DTSEDIEELVEPVAAHGPK EAINLLEPMTNDPVNYVR QDVYDLLK TPEASPEPK TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK
31.10% ADMDQFTASISETPVDVR AKEQLEIR CLVGEFVSDVLLVPEK EEVLQYCQEMYPELQITNVMEANQR
Eukaryotic translation initiation factor 4B
IF4B_HUMAN EIF4B
69,136
100.00%
3
4
20
Proteasome subunit beta type-1
PSB1_HUMAN PSMB1
26,473
100.00%
8
10
69
Kallikrein-10
KLK10_HUMAN KLK10
30,120
100.00%
9
14
231
EMIFNAER EWEEAELQAK GSGVGEQDGGLIGAEEK HYQHVLAVDPEK LNMHVNIQTGK MALENYLAALQSDPPRPHR NKVDENMVIDETLDVK QQLVETHLAR QTLIQHFQAMVK SCFETK SQVMTHLHVIEER VEAMLNDR VPYVAQEIQEEIDELLQEQR VSIDNWCR 7.53% AASIFGGAKPVDTAAR STPKEDDSSASTSQSTR VAPAQPSEEGPGR 43.60% AGGSASAMLQPLLDNQVGFK AMTTGAIAAMLSTILYSR DVFISAAER DVYTGDALR EGIREETVSLR GAVYSFDPVGSYQR LSEGFSIHTR NMQNVEHVPLSLDR 27.20% ALQLPYR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
44.8 49.9 38.8 36.2 59.0 55.4 31.9 86.3 79.4 38.5 45.9 37.4 44.8 37.9 45.4 99.8 41.5 54.3 35.4 47.4 43.7 110.0 43.5 76.5 42.3 43.2 56.6 82.8 46.3 53.3 64.2 47.2 59.7 36.7 42.0 36.4 57.2 62.7 52.9 53.0 40.4 61.0 103.0 73.5 58.8 36.7 46.1 92.4 28.6 72.8 36.0
23.6 21.5 13.4 19.2 20.9 22.0 22.1 22.0 20.8 22.8 23.7 18.8 14.8 15.3 18.3 21.5 21.6 22.1 21.7 21.1 19.0 20.4 22.0 21.6 17.9 22.1 20.9 22.4 22.7 22.2 21.4 22.4 19.3 22.7 16.2 22.4 21.9 21.4 22.0 22.0 19.8 23.3 22.3 22.0 23.3 22.0 23.1 21.4 24.1 22.6 22.6
3 4 2 2 3 4 1 2 3 2 5 0 2 2 4 17 0 4 3 2 0 61 22 5 0 8 28 7 4 6 0 3 19 3 6 0 32 0 16 4 1 13 16 6 10 4 3 11 0 8 5
0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 2 0 0 0 1 2 0 0 1 0 0 0 139 2 49 3 18 0 0 3 0 5 0 2 0 0 4 0 0 0 0 0 1 6 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 88 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,175.61 1,741.86 1,748.00 1,003.59 1,579.84 2,050.02 1,317.65 1,470.77 1,423.67 1,572.76 1,573.81 1,458.83 798.52 1,029.63 1,516.86 2,157.11 2,035.98 2,088.04 993.53 955.47 3,324.53 1,981.92 986.56 1,803.96 3,147.41 1,009.48 1,232.58 1,602.76 1,435.73 1,270.66 2,195.10 1,861.92 1,194.66 1,459.77 771.33 1,578.81 963.46 2,429.22 1,049.48 1,531.82 1,783.79 1,294.64 2,020.02 1,902.97 1,007.52 1,009.50 1,288.69 1,545.73 1,146.59 1,667.82 860.50
Table S1 page 117/159
TXND5_HUMAN TXNDC5
47,611
100.00%
6
6
24
13.70%
Parathyroid hormone-related protein PTHR_HUMAN PTHLH
20,176
100.00%
3
4
9
20.90%
Actin-related protein 2
ARP2_HUMAN ACTR2
44,744
100.00%
3
3
16
9.90%
Dihydrolipoyl dehydrogenase, mitochondrial
DLDH_HUMAN DLD
54,159
100.00%
10
12
33
24.00%
Nucleobindin-1
NUCB1_HUMAN NUCB1
53,862
100.00%
28
36
231
59.90%
Thioredoxin domain-containing protein 5
GLTCSSITILSPK LARPVVPGPR RTDEHDLMLLK TDEHDLMLLK VGDDHLLLLQGEQLR VGDDHLLLLQGEQLRR YHQGSGPILPR YMSWINK EYVESQLQR FVLSQAKDEL GYPTLLLFR GYPTLLWFR IAEVDCTAER TLAPTWEELSKK ATSEVSPNSKPSPNTK FGSDDEGR YLTQETNKVETYK DLMVGDEASELR ILLTEPPMNPTK SMLEVNYPMENGIVR ADGGTQVIDTK ALTGGIAHLFK EANLAASFGK GIEMSEVR GRIPVNTR IPNIYAIGDVVAGPMLAHK NETLGGTCLNVGCIPSK NLGLEELGIELDPR SEEQLKEEGIEYK VGKFPFAANSR AKMDAEQDPNVQVDHLNLLK APAAHPEGQLK DLELLIQTATR EFGDTGEGWETVEMHPAYTEEELR
EKLQAANAEDIK ELDFVSHHVR ELQQAVLHMEQR EVWEELDGLDPNR EVWEELDGLDPNRFNPK FEEELAAR FHPDTDDVPVPAPAGDQK FHPDTDDVPVPAPAGDQKEVDTSEK
KLEEQQR LDELKR LLERLPEVEVPQHL LPEVEVPQHL LQAANAEDIK LSQETEALGR LVTLEEFLASTQR MDAEQDPNVQVDHLNLLK NEEDDMREMEEER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
79.7 29.8 50.0 41.8 88.6 51.3 43.1 41.2 45.2 45.8 50.8 42.7 53.6 37.7 70.8 59.9 65.2 86.3 55.8 70.9 68.4 58.3 32.5 42.6 31.7 80.4 81.7 70.1 62.4 54.7 41.8 52.7 68.5 56.8 64.1 71.6 78.5 59.3 57.7 55.1 76.6 61.9 42.3 35.9 29.1 63.2 54.7 80.5 83.9 121.0 29.8
22.0 9.5 21.8 22.2 19.6 18.1 21.7 21.0 23.0 22.8 18.6 20.9 21.0 22.1 22.8 16.1 23.5 20.7 20.5 21.9 22.7 20.2 23.2 22.1 16.3 19.6 23.1 21.7 22.8 21.7 21.6 23.4 21.1 15.3 23.0 23.0 23.0 21.9 22.3 23.4 21.8 21.2 23.7 23.5 17.8 22.8 21.5 23.4 20.3 21.8 9.0
4 0 6 1 28 1 10 7 2 5 10 4 2 1 2 4 2 5 10 1 2 2 1 2 1 2 2 4 2 0 0 10 9 0 2 4 16 11 2 8 5 0 1 2 0 18 7 15 22 4 0
0 1 35 0 51 22 54 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 10 0 0 3 2 4 0 0 2 0 0 2 0 0 0 2 2 0 0 1 0 0 0 4 11 2
0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,376.75 1,061.66 1,386.71 1,214.61 1,705.92 1,862.03 1,224.65 941.46 1,151.57 1,149.62 1,079.63 1,152.62 1,163.54 1,402.76 1,643.82 882.36 1,616.82 1,350.62 1,353.75 1,783.84 1,104.55 1,127.66 1,007.52 936.45 912.54 1,995.07 1,819.87 1,567.83 1,581.77 1,193.64 2,294.15 1,118.60 1,272.72 2,828.20 1,329.70 1,238.63 1,481.75 1,571.73 2,057.99 964.47 1,905.90 2,694.25 930.50 773.45 1,671.94 1,160.63 1,072.56 1,103.57 1,506.82 2,095.01 1,743.64
Table S1 page 118/159
ES1 protein homolog, mitochondrial ES1_HUMAN
C21orf33
28,152
100.00%
2
2
3
NVDTNQDR QFEHLDPQNQHTFEAR RFEEELAAR VNVPGSQAQLK YLESLGEEQR YLESLGEEQRK YLQEVIDVLETDGHFR 13.10% EVVEAHVDQK ITDLANLSAANHDAAIFPGGFGAAK
NIF3-like protein 1
NIF3L_HUMAN NIF3L1
41,951
100.00%
2
2
8
Prolyl endopeptidase
PPCE_HUMAN PREP
80,684
100.00%
5
5
15
41,498
100.00%
7
9
30
92,454
100.00%
21
24
118
Protein arginine N-methyltransferase ANM1_HUMAN PRMT1 1
Endoplasmin
ENPL_HUMAN HSP90B1
6.37% ALMQVVDFLSR GIDGVSVTSFSAR 11.70% LPEADDIQYPSMLLLTADHDDR NILQLHDLTTGALLK SDGTETSTNLHQK TFPLDVGSIVGYSGQK VFLDPNILSDDGTVALR 25.20% ANKLDHVVTIIK ATLYVTAIEDR DVAIKEPLVDVVDPK TGEEIFGTIGMRPNAK TGFSTSPESPYTHWK VEEVELPVEK WLAPDGLIFPDR 35.00% DISTNYYASQK EAESSPFVER EEASDYLELDTIK EESDDEAAVEEEEEEKKPK EFEPLLNWMK ELISNASDALDK ELISNASDALDKIR FAFQAEVNR FQSSHHPTDITSLDQYVER GLFDEYGSK GVVDSDDLPLNVSR IADDKYNDTFWK IYFMAGSSR LGVIEDHSNR LIINSLYK LISLTDENALSGNEELTVK NLLHVTDTGVGMTR SGTSEFLNK SGYLLPDTK SILFVPTSAPR TDDEVVQREEEAIQLDGLNASQIR
Peroxiredoxin-5, mitochondrial
PRDX5_HUMAN PRDX5
22,008
100.00%
9
11
27
VFITDDFHDMMPK YSQFINFPIYVWSSK 44.90% ETDLLLDDSLVSIFGNR ETDLLLDDSLVSIFGNRR FSMVVQDGIVK GVLFGVPGAFTPGCSK LLADPTGAFGK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
32.0 35.0 42.2 52.3 45.4 51.5 110.0 34.1 39.2 72.8 81.2 64.7 57.8 31.5 73.9 115.0 32.3 56.3 58.3 37.6 48.8 45.7 38.9 59.3 44.4 88.7 49.6 43.0 92.5 108.0 44.4 86.1 57.2 111.0 52.5 38.3 59.3 39.8 75.1 59.9 31.9 46.2 65.1 44.4 33.4 65.3 89.4 38.5 59.7 33.5 33.8
18.6 21.8 23.8 20.5 22.2 22.6 22.8 23.0 21.4 22.2 22.0 20.5 14.9 20.8 21.8 21.5 12.8 21.7 18.7 22.1 21.0 20.6 21.0 20.5 21.7 22.1 18.4 23.1 23.1 21.4 23.1 21.4 19.4 22.1 21.4 21.2 22.4 14.3 21.6 22.0 21.6 21.7 20.6 21.4 17.4 22.6 22.0 20.7 21.7 22.6 22.9
1 3 3 19 4 4 8 1 0 6 2 0 2 1 2 7 0 4 6 2 2 4 2 8 6 4 0 3 15 10 4 0 4 13 2 2 7 4 22 3 1 4 9 0 1 4 7 2 2 1 2
0 3 0 0 0 1 18 0 2 0 0 3 0 0 0 0 4 0 5 1 0 0 0 0 0 0 1 0 0 2 0 4 0 0 0 0 2 0 0 4 0 0 0 4 0 0 0 1 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
961.43 1,996.93 1,120.58 1,140.64 1,223.59 1,351.69 1,933.97 1,153.59 2,442.24 1,294.68 1,295.66 2,544.19 1,649.96 1,417.66 1,667.86 1,844.98 1,350.81 1,251.66 1,636.92 1,736.86 1,724.79 1,170.63 1,399.74 1,289.60 1,150.54 1,525.73 2,219.97 1,322.65 1,275.64 1,544.83 1,081.54 2,260.06 1,015.47 1,485.76 1,515.71 1,047.49 1,139.58 963.59 2,046.06 1,513.78 982.48 993.53 1,187.68 2,728.34 1,627.71 1,878.94 1,906.98 2,063.08 1,238.65 1,593.81 1,089.59
Table S1 page 119/159
THLPGFVEQAEALK VGDAIPAVEVFEGEPGNK VGDAIPAVEVFEGEPGNKVNLAELFK
Heterogeneous nuclear ribonucleoprotein A/B
ROAA_HUMAN HNRNPAB
36,207
100.00%
3
3
34
Carboxypeptidase A4
CBPA4_HUMAN CPA4
47,334
100.00%
18
21
324
VNLAELFK 13.30% EVYQQQQYGSGGR FGEVVDCTIK GFGFILFK MFVGGLSWDTSKK 50.60% APDAEELDK APDAEELDKVAR DPAITSILEK DTGTYGFLLPANQIIPTAEETWLGLK
EWISQATAIWTAR FFGDQVLR IVSDYQR KAPDAEELDK KIVSDYQR LSQLVNSNNLK MDIFLLPVANPDGYVYTQTQNR
NGDEISK NPGSSCIGADPNR RPAVWLNAGIHSR SPSSFNRPVDVLVPSVSLQAFK SQGLEYAVTIEDLQALLDNEDDEMQHNEGQER
Galectin-1
LEG1_HUMAN LGALS1
14,698
100.00%
2
2
4
17.80%
Myoferlin
MYOF_HUMAN MYOF
234,698
99.50%
2
2
4
1.16%
Microtubule-associated protein RP/EB family member 1
MARE1_HUMAN MAPRE1
29,982
100.00%
4
6
11
24.30%
Hyaluronan and proteoglycan link protein 3 Semaphorin-3B
HPLN3_HUMAN HAPLN3
40,876
100.00%
2
2
3
4.44%
SEM3B_HUMAN SEMA3B
83,104
100.00%
6
6
14
10.90%
SVVDFIQK TIMEHVR LNLEAINYMAADGDFK LPDGYEFK GPVGTVSEAQLAR VIVESASNIPK FFDANYDGKDYDPVAAR KPLTSSSAAPQRPISTQR LEHEYIQNFK QGQETAVAPSLVAPALNKPK LTLTEAR VGQLFAAWK AASVLVGEELYSGVAADLMGR AFLGPFAHK DFPDDVIQFAR ETAVEAAPALGR LFVGAENHVASLNLDNISK SAVAQIALHR DHFLMDGQVR GNVLLEDGK GNVLLEDGKGR GTTEGSAVCVFTMK HVSLYQPQLATRPWIQDIEGASAK
INSSLQLPDR ISLPLGSEERPFLR MLLLQPQAR SQSLRPTK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
51.1 95.1 37.6 57.7 98.9 55.7 55.5 43.6 51.0 34.7 66.8 39.4 76.6 59.3 51.6 55.3 40.6 65.6 83.5 53.6 49.6 32.0 54.1 74.9 52.7 43.4 99.2 31.8 72.2 48.0 35.2 36.7 33.6 56.1 30.6 49.0 49.9 31.3 60.0 66.9 46.7 50.2 35.1 41.6 36.0 63.9 39.8 37.3 33.9 55.2 35.3
21.8 22.1 19.2 19.9 21.0 22.7 22.7 23.1 20.1 22.0 20.8 18.8 23.0 23.1 23.1 22.6 20.3 22.2 22.0 22.3 19.1 19.9 18.1 16.9 20.9 22.4 22.4 20.9 21.1 21.9 20.1 19.0 23.4 16.1 23.3 21.3 22.2 23.8 22.6 22.2 21.0 18.2 20.6 21.6 21.0 20.5 20.2 22.4 20.6 22.0 22.5
2 2 0 3 22 13 10 2 8 0 26 0 69 35 6 18 8 26 17 2 1 0 5 0 7 2 3 1 2 2 0 0 1 1 1 2 1 2 3 4 0 2 2 3 2 4 0 1 2 26 5
1 0 4 0 0 0 0 0 0 2 0 3 0 0 0 12 0 0 35 0 0 8 33 1 0 0 0 0 0 0 1 2 0 5 0 0 0 0 0 0 2 0 2 0 0 0 2 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,539.82 1,827.91 2,742.44 933.54 1,499.69 1,167.57 928.53 1,471.73 987.46 1,313.67 1,086.60 2,848.48 1,532.79 981.52 880.45 1,115.56 1,008.55 1,229.69 2,571.26 762.36 1,344.60 1,476.82 2,374.28 3,705.65 935.52 901.46 1,784.85 968.47 1,284.69 1,156.66 1,963.88 1,925.06 1,320.66 2,019.12 803.46 1,019.57 2,124.06 987.54 1,322.64 1,184.63 2,041.07 1,065.62 1,233.57 944.51 1,157.63 1,503.68 2,708.42 1,142.62 1,613.90 1,085.61 916.52
Table S1 page 120/159
STALVVDGELYTGTVSSFQGNDPAISR
Hsp90 co-chaperone Cdc37
CDC37_HUMAN CDC37
44,450
100.00%
4
4
9
19.00%
Obg-like ATPase 1
OLA1_HUMAN OLA1
44,727
100.00%
6
6
21
18.20%
Nck-associated protein 1
NCKP1_HUMAN NCKAP1
128,777
99.50%
2
2
4
2.39%
Inositol polyphosphate 1phosphatase mRNA export factor
INPP_HUMAN INPP1
43,981
99.50%
2
2
2
6.27%
RAE1L_HUMAN RAE1
40,951
100.00%
2
2
4
7.61%
Extracellular matrix protein 1
ECM1_HUMAN ECM1
60,655
100.00%
20
21
239
VPGLHHTYDVLFLGTGDGR EGEEAGPGDPLLEAVPK LGPGGLDPVEVYESLPEELQK QYMEGFNDELEAFKER SMVNTKPEKTEEDSEEVR GGDGIKPPPIIGR IGIVGLPNVGK IPAFLNVVDIAGLVK NYIVEDGDIIFFK VPVPDER YLEANMTQSALPK ELATVLSDQPGLLGPK NNNQQLAQLQK NIFGEESNEFTNDWGEK VASEALAR GLIVYQLENQPSEFR SSNPMMVLQLPER
52.80% ACPSHQPDISSGLELPFPPGVPTLDNIK AWEDTLDKYCDR ELLALIQLER ELPSLQHPNEQK EVGPPLPQEAVPLQK FCEAEFSVK FSCFQEEAPQPHYQLR HPPSPTR LDGFPPGRPSPDNLNQICLPNR LLPAQLPAEK LLPAQLPAEKEVGPPLPQEAVPLQK
LTFINDLCGPR LVWEEAMSR NLPATDPLQR NVALVSGDTENAK QGETLNFLEIGYSR QHVVYGPWNLPQSSYSHLTR QLRPEHFQEVGYAAPPSPPLSR SLPMDHPDSSQHGPPFEGQSQVQPPPSQEATPLQQEK
Far upstream element-binding protein 1
FUBP1_HUMAN FUBP1
67,543
100.00%
9
10
23
Lysyl oxidase homolog 2
LOXL2_HUMAN LOXL2
86,705
99.90%
2
2
3
Fructose-bisphosphate aldolase A
ALDOA_HUMAN ALDOA
39,403
100.00%
28
38
1360
SQGGWGHR 16.50% EMVLELIR IGGDAGTSLNSNDYGYGGQK IGGNEGIDVPIPR IQFKPDDGTTPER IQIAPDSGGLPER IQNDAGVR MVMIQDGPQNTGADKPLR RPLEDGDQPDAK RPLEDGDQPDAKK 2.58% GGAYIGEGR TPVMEGYVEVK 68.70% AAQEEYVK AAQEEYVKR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
37.9 41.8 76.9 91.6 30.7 52.3 38.8 46.3 78.3 45.7 36.6 76.5 46.1 56.2 86.4 31.5 32.9 43.9 33.2 59.4 74.2 68.1 57.8 43.1 41.2 35.5 27.3 36.4 36.5 65.5 61.0 36.0 98.4 111.0 32.5 29.9 21.1 56.4 51.0 85.1 89.8 46.4 77.0 35.0 42.6 38.3 33.9 32.0 43.9 60.5 92.5
21.8 21.9 22.1 20.5 18.2 20.3 18.7 13.2 12.8 23.0 19.0 22.7 18.2 21.4 16.8 23.4 21.7 21.7 20.9 18.2 16.6 22.9 18.8 20.1 20.3 25.0 21.6 14.0 12.0 23.2 22.3 22.1 23.3 22.7 21.5 20.8 17.9 20.1 23.6 19.1 21.4 23.1 21.9 21.3 22.2 22.1 21.9 23.3 22.1 21.6 22.9
0 0 4 3 0 0 0 3 9 1 3 4 2 2 1 1 1 3 0 3 32 15 21 6 0 3 0 7 0 8 30 4 23 57 0 0 0 4 2 2 5 0 2 2 1 2 0 1 2 10 59
1 3 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 6 0 1 0 9 0 0 0 0 0 1 3 0 0 0 0 0 2 0 0 2 0 3 0 0 0 14
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,784.37 2,054.05 1,707.84 2,269.16 2,021.89 2,123.98 1,276.74 1,066.66 1,568.94 1,572.80 811.43 1,481.73 1,637.91 1,298.68 2,015.86 816.46 1,792.92 1,501.75 2,986.50 1,571.68 1,197.72 1,419.72 1,601.89 1,116.50 2,036.93 791.42 2,477.24 1,079.65 2,662.52 1,305.66 1,136.54 1,124.61 1,317.67 1,626.81 2,369.18 2,476.27 4,035.88 884.41 1,002.57 1,973.88 1,336.72 1,503.74 1,352.72 872.46 2,002.97 1,340.65 1,468.74 879.43 1,267.62 937.46 1,093.56
Table S1 page 121/159
ADDGRPFPQVIK ALANSLACQGK ALQASALK CPLLKPWALTFSYGR DGADFAK ELSDIAHR FSHEEIAMATVTALR FSHEEIAMATVTALRR GGVVGIKVDK GILAADESTGSIAK GILAADESTGSIAKR GVVPLAGTNGETTTQGLDGLSER
IGEHTPSALAIMENANVLAR KDGADFAK KELSDIAHR LQSIGTENTEENR LQSIGTENTEENRR PYQYPALTPEQK PYQYPALTPEQKK QLLLTADDR SKGGVVGIK VDKGVVPLAGTNGETTTQGLDGLSER
VLAAVYK YASICQQNGIVPIVEPEILPDGDHDLK YASICQQNGIVPIVEPEILPDGDHDLKR
Fructose-1,6-bisphosphatase 1
F16P1_HUMAN FBP1
36,797
100.00%
8
8
28
Src substrate cortactin
SRC8_HUMAN CTTN
61,567
99.50%
2
2
4
Nidogen-1
NID1_HUMAN NID1
136,358
100.00%
21
25
145
YTPSGQAGAAASESLFVSNHAY 33.40% AGIAHLYGIAGSTNVTGDQVK AISSAVR APVILGSPDDVLEFLK DFDPAVTEYIQR EAVLDVIPTDIHQR GTGELTQLLNSLCTAVK STDEPSEKDALQPGR YVGSMVADVHR 4.18% FGVQSER TQTPPVSPAPQPTEER 19.00% AAECVHR AECLNPSQPSR ALEGLQYPFAVTSYGK ASLHGGEPTTIIR EDLSPSITQR EYTVTEPERDGASPSR GNLYWTDWNR IETSYMDGTNR IYTYQWR KALEGLQYPFAVTSYGK MVYWTDITEPSIGR NGFSITGGEFTR NIFWTDSNLDR NLYFTDWK QAEVTFVGHPGNLVIK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0%
45.4 80.4 64.5 28.3 46.1 56.8 104.0 33.8 34.9 103.0 107.0 140.0 90.9 55.0 36.3 74.9 48.8 67.2 55.1 76.1 43.9 85.1 45.5 68.3 91.7 143.0 31.5 39.7 86.8 67.6 60.3 70.4 61.9 34.4 48.7 42.7 38.6 39.5 75.7 41.9 49.7 46.5 36.9 72.1 35.0 72.3 104.0 61.3 70.8 30.2 29.3
22.1 23.8 22.3 21.8 22.6 21.9 22.3 21.5 20.2 23.5 21.5 21.6 21.2 22.3 22.4 21.9 23.0 23.1 22.8 23.1 20.9 20.9 18.0 21.0 19.7 21.0 21.5 24.8 19.7 22.4 21.3 21.3 22.2 22.4 23.4 22.1 18.6 21.5 22.1 21.5 23.0 22.1 21.4 17.2 22.0 21.3 21.7 21.2 22.2 21.2 19.7
14 16 39 0 14 42 94 0 2 78 8 20 19 4 0 9 3 104 6 27 3 1 18 0 0 204 0 2 13 4 2 2 1 2 2 2 1 1 18 3 6 8 4 8 2 2 11 4 6 1 0
21 0 0 1 0 0 180 0 0 0 4 4 283 0 7 0 7 0 4 0 0 7 0 5 5 12 2 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 3 0 0 0 0 1
0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,342.71 1,132.58 801.48 1,808.95 723.33 940.49 1,691.84 1,831.95 971.59 1,332.70 1,488.80 2,272.14 2,107.10 851.43 1,068.58 1,490.71 1,646.81 1,434.73 1,562.82 1,044.57 844.53 2,614.33 763.47 3,020.50 3,176.61 2,228.03 2,072.08 703.41 1,712.95 1,453.70 1,605.86 1,804.95 1,629.77 1,249.60 822.41 1,734.87 842.39 1,258.59 1,743.90 1,351.73 1,145.58 1,793.83 1,324.61 1,302.56 1,029.52 1,871.99 1,683.81 1,285.62 1,380.65 1,086.53 1,708.94
Table S1 page 122/159
1-phosphatidylinositol-4,5bisphosphate phosphodiesterase beta-3
PLCB3_HUMAN PLCB3
138,785
100.00%
5
5
9
5.51%
Neurolysin, mitochondrial
NEUL_HUMAN NLN
80,636
100.00%
2
2
2
3.27%
Tax1-binding protein 3
TX1B3_HUMAN TAX1BP3
13,717
99.50%
2
2
3
19.40%
Plexin-B2
PLXB2_HUMAN PLXNB2
205,109
100.00%
2
2
3
1.52%
Gamma-glutamylcyclotransferase
GGCT_HUMAN GGCT
20,990
100.00%
6
6
27
37.80%
UPF0364 protein C6orf211
CF211_HUMAN C6orf211
51,156
100.00%
3
3
5
9.75%
Proteasome activator complex subunit 1
PSME1_HUMAN PSME1
28,706
100.00%
9
11
41
36.90%
Alpha-enolase
ENOA_HUMAN ENO1
47,152
100.00%
34
47
2850
77.90%
QCVAEGSPQR QDLGSPEGIAVDHLGR SDIDAVYVTTNGIIATSEPPAK VLFETDLVNPR VYYREDLSPSITQR YALSNSIGPVR EAQVDAEAQR EVVLDANTTQFK LLDGLAQAQAEGR LNEVLYPPLRPSQAR LVAGQQQVLQQLAEEEPK LVNTGLLTLR NLNEDDTFLVFSK RSEEVVR VSEGGPAEIAGLQIGDK EASPNPEDGIVR SSGGPGAGLCLFPLDK ENGLPLEYQEK LDFGNSQGK NPSAAFFCVAR SNLNSLDEQEGVK SYLMTNYESAPPSPQYK VSEEIEDIIK HGEEGVEAEK LRNELQTDKPFIPLVEK TIEDLDENQLKDEFFK APLDIPVPDPVK APLDIPVPDPVKEK EPALNEANLSNLK IEDGNNFGVAVQEK ISELDAFLKEPALNEANLSNLK IVVLLQR NAYAVLYDIILK QLVHELDEAEYR TENLLGSYFPK AAVPSGASTGIYEALELR AGYTDKVVIGMDVAASEFFR AVEHINK DATNVGDEGGFAPNILENK DATNVGDEGGFAPNILENKEGLELLK
DYPVVSIEDPFDQDDWGAWQK EGLELLK EIFDSR FTASAGIQVVGDDLTVTNPK GNPTVEVDLFTSK GVPLYR HIADLAGNSEVILPVPAFNVINGGSHAGNK
IDKLMIEMDGTENK IEEELGSK IGAEVYHNLK KLNVTEQEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
35.8 92.5 53.6 71.6 61.8 81.3 45.7 45.8 36.3 32.2 88.9 47.9 40.9 40.3 93.6 54.0 40.5 59.0 47.2 61.8 74.9 81.0 84.1 33.6 35.8 95.6 47.5 52.0 46.5 77.3 96.1 46.9 86.0 62.2 56.0 161.0 84.9 40.7 111.0 77.3 113.0 42.4 31.7 128.0 110.0 31.4 60.7 72.5 56.8 67.0 52.7
19.8 22.5 21.2 22.5 22.0 22.6 21.0 23.4 21.8 17.1 20.0 16.1 22.5 23.9 21.7 21.7 22.9 22.6 22.7 21.4 22.6 19.9 23.7 20.4 15.9 21.7 18.9 18.5 22.0 22.9 18.4 12.8 18.6 21.6 22.0 21.5 21.7 19.5 21.4 21.6 17.1 20.9 22.0 21.7 23.0 21.6 21.0 22.8 23.5 22.8 23.4
3 6 3 29 2 12 2 1 1 0 4 1 1 1 2 2 1 1 4 2 8 4 8 1 0 2 2 2 2 2 0 4 14 2 7 354 2 20 151 0 22 14 3 277 163 2 0 20 33 69 53
0 6 0 0 3 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 3 0 0 2 0 0 1 0 87 6 0 7 84 4 0 0 38 0 0 11 31 0 30 11
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,131.52 1,663.84 2,262.15 1,302.71 1,726.88 1,176.64 1,116.53 1,364.71 1,341.71 1,752.98 2,008.07 1,099.68 1,541.75 874.47 1,640.85 1,283.62 1,575.78 1,319.65 965.47 1,239.59 1,432.69 1,991.91 1,174.62 1,084.49 2,040.15 1,983.96 1,260.72 1,517.86 1,412.74 1,519.74 2,429.29 840.57 1,395.79 1,501.73 1,268.65 1,804.94 2,192.07 810.45 1,960.93 2,743.38 2,510.12 801.47 766.37 2,033.06 1,406.72 704.41 3,011.57 1,652.79 904.46 1,143.62 1,088.60
Table S1 page 123/159
LAMQEFMILPVGAANFR LAQANGWGVMVSHR LMIEMDGTENK LNVTEQEK LNVTEQEKIDK NFRNPLAK SCNCLLLK SGETEDTFIADLVVGLCTGQIK SGKYDLDFK SPDDPSR TIAPALVSK VNQIGSVTESLQACK VVIGMDVAASEFFR YDLDFK YDLDFKSPDDPSR YGKDATNVGDEGGFAPNILENK
N-acetylglucosamine-1phosphotransferase subunit gamma Follistatin-related protein 1
GNPTG_HUMAN GNPTG
33,956
99.90%
2
2
4
13.40%
FSTL1_HUMAN FSTL1
34,967
100.00%
5
5
70
14.90%
Protocadherin Fat 1
FAT1_HUMAN FAT1
506,251
100.00%
5
5
10
1.55%
Annexin A10
ANX10_HUMAN ANXA10
37,261
100.00%
10
10
50
31.80%
Adenylosuccinate synthetase isozyme 2
PURA2_HUMAN ADSS
50,080
100.00%
6
7
17
18.60%
Annexin A3
ANXA3_HUMAN ANXA3
36,359
100.00%
17
20
179
48.00%
YISPDQLADLYK YNQLLR QWDQVEQDLADELITPQGHEK VVEEPNAFGVNNPFLPQASR GAQTQTEEEMTR ICANVFCGAGR LDSSEFLK LSFQEFLK YVQELQK AEISEFAPPNTPVVMVK AFEVNPQGVLLTSSAIK IGEETGVIETSDR IVSGDSENLFK VQATDADAGLNRK DKPAYFAYR DTLMNLVQGTR GVGTDENCLIEILASR LYSAIHDFGFHNK MMIAEAYQSMYGR SEIDLLTIR SLFHDIR SYQQLR TMLQMILCNK TNGEIFQMR ELPVNAQNYVR FIEDELQIPVK LDGEIIPHIPANQEVLNK LDILDMFTEIK TLPGWNTDISNAR VGIGAFPTEQDNEIGELLQTR ALLTLADGR ALLTLADGRR DISQAYYTVYK DISQAYYTVYKK DYPDFSPSVDAEAIQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
114.0 41.4 78.8 55.3 42.9 35.2 47.0 98.1 50.1 44.9 49.6 139.0 117.0 38.8 68.8 52.0 90.8 37.6 28.6 62.4 82.0 49.8 43.2 57.1 37.7 37.5 67.6 47.4 31.8 27.1 38.2 65.0 92.1 19.6 102.0 71.2 34.0 34.0 46.6 71.1 37.0 52.9 38.8 89.6 60.0 107.0 64.9 36.2 64.5 44.0 85.8
21.5 22.1 19.9 23.7 22.8 23.8 22.3 22.2 21.5 16.5 15.9 22.8 22.6 19.7 20.5 21.7 22.9 22.8 22.0 22.1 17.6 21.5 22.3 21.0 21.5 22.7 19.3 22.3 23.3 22.9 22.4 23.6 22.2 22.6 16.1 21.9 22.6 22.0 22.9 22.0 23.2 22.5 18.9 21.8 22.3 21.0 21.2 19.4 22.6 22.8 21.1
297 0 79 25 3 5 13 6 10 5 13 186 349 5 11 0 169 68 0 3 41 7 5 16 1 1 6 1 1 0 2 9 4 0 6 20 1 1 2 4 2 5 0 2 2 2 13 2 11 4 19
41 3 0 0 0 0 0 0 54 0 0 2 0 0 6 4 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 2 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,923.98 1,525.77 1,296.58 960.50 1,316.71 959.54 1,007.50 2,353.16 1,072.53 773.34 899.56 1,633.82 1,556.78 800.38 1,554.71 2,309.11 1,425.73 806.45 2,479.17 2,185.10 1,396.60 1,224.56 938.48 1,011.55 907.49 1,844.95 1,773.98 1,405.68 1,208.62 1,358.70 1,130.56 1,247.64 1,746.87 1,548.76 1,598.67 1,059.61 887.47 794.42 1,251.63 1,095.53 1,302.68 1,330.73 2,000.08 1,353.70 1,444.72 2,287.16 929.54 1,085.64 1,350.66 1,478.75 1,781.82
Table S1 page 124/159
EYQAAYGK GAGTNEDALIEILTTR GIGTDEFTLNR HYGYSLYSAIK MLISILTER NTPAFLAER QDAQILYK SDTSGDYEITLLK SEIDLLDIR SLGDDISSETSGDFR SLGDDISSETSGDFRK VDEHLAK AVELLR FILNLPTFSVR NGIHDLDNISFPK NGYELSPTAAANFTR VAASNIVQMK VAASNIVQMKDDHDK GIMGEDTYPYQGK GNFVSPVK GTGPYPPSVDWR LQTFASNWR MALNQFSDMSFAEIK TPDKVNHAVLAVGYGEK TYSTEEYHHR VNHAVLAVGYGEK FDQNLDTK NSWGPEWGSNGYVK VFREPLFLDLPK ALYLSDNDFEILPPDIGK EIGELTQLK LQILSLR LTVLPPELGNLDLTGQK DTDSSVASEVR ELANFDPSRPGPPSGR IQASQQDDSMR QGNAVTLGDYYQGR SSSAGGQGSYVPLLR AASITSEVFNK GNENANGAPAITLLIR LAESVEK SLFSSIGEVESAK TNLIVNYLPQNMTQDELR VLVDQTTGLSR AYAALAALEK EDITQSAQHALR LNQLKPGLQYK VLAGETLSVNDPPDVLDR VLQDMGLPTGAEGR
Proteasome subunit beta type-2
PSB2_HUMAN PSMB2
22,820
100.00%
6
6
31
29.90%
Cathepsin H
CATH_HUMAN CTSH
37,376
100.00%
8
10
161
25.10%
Cathepsin L2
CATL2_HUMAN CTSL2
37,311
100.00%
3
3
24
10.20%
Ras suppressor protein 1
RSU1_HUMAN RSU1
31,524
100.00%
4
4
8
18.40%
Lipolysis-stimulated lipoprotein receptor
LSR_HUMAN LSR
71,421
100.00%
5
5
238
10.30%
FACT complex subunit SPT16
SP16H_HUMAN SUPT16H
119,899
100.00%
3
3
10
3.25%
ELAV-like protein 1
ELAV1_HUMAN ELAVL1
36,075
100.00%
3
3
10
12.90%
Interleukin enhancer-binding factor 3 ILF3_HUMAN ILF3
95,321
100.00%
5
5
21
7.27%
PPT1_HUMAN PPT1
34,176
100.00%
4
4
34
21.20% CPSPPMINLISVGGQHQGVFGLPR ETIPLQETSLYTQDR
Palmitoyl-protein thioesterase 1
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
48.3 117.0 75.0 39.7 66.4 41.2 58.5 87.1 73.7 83.3 85.4 43.7 38.8 56.0 67.6 90.0 75.8 67.9 87.2 30.6 44.8 44.0 107.0 61.2 42.3 59.7 42.0 42.2 42.9 46.5 36.7 35.0 48.1 70.6 29.9 77.9 92.0 102.0 75.9 67.8 38.6 51.3 46.6 85.5 47.8 40.7 42.6 83.1 59.9 38.4 88.7
18.5 22.4 23.3 22.2 21.0 24.0 22.6 21.8 24.9 18.9 20.8 19.0 22.0 17.0 22.3 22.0 23.4 21.6 20.1 23.6 21.6 23.3 20.7 20.4 18.7 22.1 22.0 20.9 18.2 22.3 21.9 19.6 15.7 21.0 22.6 19.1 22.1 22.6 22.7 20.2 25.1 22.1 21.8 22.3 20.2 23.4 18.4 21.2 23.2 20.4 22.6
3 35 14 1 23 2 8 14 10 5 4 4 3 10 2 2 12 2 52 2 18 15 55 1 1 6 11 2 0 2 2 2 2 28 0 102 44 63 6 2 2 3 1 6 1 1 2 7 10 0 16
0 3 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 11 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
929.44 1,673.87 1,222.61 1,301.65 1,075.62 1,018.53 978.53 1,441.71 1,073.58 1,585.70 1,713.79 811.43 700.44 1,306.75 1,469.74 1,611.78 1,076.58 1,686.81 1,458.66 847.47 1,331.64 1,122.57 1,731.81 1,797.95 1,322.58 1,356.73 980.47 1,580.71 1,473.85 2,020.03 1,030.58 842.55 1,808.02 1,165.53 1,696.84 1,294.57 1,541.73 1,478.76 1,166.61 1,623.88 775.42 1,353.69 2,162.09 1,188.66 1,020.57 1,368.69 1,301.76 1,909.99 1,459.72 2,577.31 1,793.89
Table S1 page 125/159
Ornithine aminotransferase, mitochondrial
OAT_HUMAN OAT
48,518
100.00%
4
4
10
12.30%
X-ray repair cross-complementing protein 5
XRCC5_HUMAN XRCC5
82,689
100.00%
8
10
25
11.10%
Ribonuclease inhibitor
RINI_HUMAN RNH1
49,956
100.00%
8
8
28
23.00%
Dystroglycan
DAG1_HUMAN DAG1
97,424
100.00%
7
8
63
12.40%
Stathmin
STMN1_HUMAN STMN1
17,285
100.00%
4
5
9
30.90%
Selenide, water dikinase 1
SPS1_HUMAN SEPHS1
42,893
99.50%
2
2
4
8.42%
Dihydropteridine reductase
DHPR_HUMAN QDPR
25,772
100.00%
2
2
5
14.30%
Polymerase I and transcript release factor
PTRF_HUMAN PTRF
43,459
100.00%
8
10
30
22.30%
Cathepsin Z
CATZ_HUMAN CTSZ
33,850
100.00%
5
6
52
19.50%
Myosin light polypeptide 6
MYL6_HUMAN MYL6
16,912
100.00%
6
8
20
46.40%
GINESYKK LQQGYNAMGFSQGGQFLR GIYLWDVEGR LPSDVVTAVR TVQGPPTSDDIFER VAIAALEVLEEENLAENADK ANPQVGVAFPHIK EEASGSSVTAEEAK EEASGSSVTAEEAKK FSEEQR LGGHGPSFPLK VITMFVQR YAPTEAQLNAVDALIDSMSLAK YAYDKR ELCQGLGQPGSVLR ELSLAGNELGDEGAR ELTVSNNDINEAGVR LDDCGLTEAR LEDAGVR LGDVGMAELCPGLLHPSSR VNPALAELNLR WAELLPLLQQCQVVR EGAMSAQLGYPVVGWHIANK IPSDTFYDHEDTTTDKLK LFDMSAFMAGPGNAK LGCSLNQNSVPDIHGVEAPAR LREQQLVGEK SFSEVELHNMK VTIPTDLIASSGDIIK AIEENNNFSK ASGQAFELILSPR DLSLEEIQK SKESVPEFPLSPPK ESFNPESYELDK IIEVAPQVATQNVNPTPGATS MTDSFTEQADQVTAEVGK NRPSSGSLIQVVTTEGR AHATTSNTVSK GEAGDLR IIGAVDQIQLTQAQLEER IREGQVEVLK KLEVNEAELLR QAEMEGAVQSIQGELSK VMIYQDEVK VMIYQDEVKLPAK IVTSTYKDGK NSWGEPWGER NVDGVNYASITR STYPRPHEYLSPADLPK VGDYGSLSGR ALGQNPTNAEVLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
34.1 121.0 52.8 54.7 76.6 94.3 46.9 103.0 75.7 31.3 39.2 32.7 113.0 32.0 52.8 110.0 112.0 51.9 40.6 57.3 69.9 62.4 49.7 29.9 95.9 45.8 51.9 44.5 122.0 53.6 35.1 48.3 36.2 60.4 71.3 141.0 55.6 32.2 32.4 148.0 26.5 65.7 130.0 33.7 30.6 36.0 40.2 80.3 36.8 83.2 55.9
20.3 21.8 22.0 19.8 22.5 22.0 20.1 20.1 21.9 20.8 20.8 21.6 21.6 20.5 22.1 21.9 22.3 21.0 23.4 22.1 18.2 19.1 22.5 21.6 20.1 22.1 22.0 21.4 18.2 21.8 22.4 24.0 21.7 19.1 21.3 19.4 20.8 22.0 20.8 19.0 19.5 19.9 22.2 23.2 21.4 20.6 17.6 22.6 22.2 21.6 21.4
2 15 2 4 2 2 2 6 4 3 2 1 3 1 3 4 4 2 1 0 7 4 1 0 23 0 3 7 21 2 1 2 2 2 2 3 0 1 1 6 0 4 7 1 0 1 2 26 0 12 2
0 0 0 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 3 0 0 2 3 0 3 0 0 0 0 0 0 2 0 0 0 2 0 0 4 1 3 0 0 2 0 0 0 9 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
938.49 2,001.96 1,207.61 1,056.61 1,561.75 2,141.10 1,377.76 1,394.63 1,522.72 795.36 1,109.61 1,009.55 2,321.17 815.41 1,513.78 1,530.74 1,630.80 1,149.52 759.40 2,024.99 1,209.70 1,853.01 2,144.06 2,125.99 1,588.71 2,234.10 1,199.68 1,336.62 1,642.93 1,165.55 1,388.75 1,074.57 1,541.82 1,457.64 2,107.10 1,972.88 1,800.96 1,116.56 717.35 2,025.10 1,170.68 1,313.74 1,804.88 1,140.56 1,549.83 1,111.60 1,217.53 1,308.65 1,971.00 1,010.49 1,354.73
Table S1 page 126/159
Plasminogen activator inhibitor 2
PAI2_HUMAN SERPINB2
Transcriptional activator protein Pur- PURB_HUMAN PURB beta
46,580
100.00%
13
14
66
33,224
100.00%
3
3
5
EAFQLFDR ILYSQCGDVMR NKDQGTYEDYVEGLR SDEMNVK VLDFEHFLPMLQTVAK 36.40% ANFSGMSER GKIPNLLPEGSVDGDTR GSYPDAILQAQAADK IPNLLPEGSVDGDTR ITNCILFFGR LEEHYELR LNIGYIEDLK MAEDEVEVYIPQFK MVLVNAVYFK SLSSAINASTGNYLLESVNK SMGMEDAFNK TPVQMMYLR YYSSEPQAVDFLECAEEAR 24.40% DSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPR GGGEQETQELASK GGGGFGAGPGPGGLQSGQTIALPAQGLIEFR
V-type proton ATPase subunit S1
VAS1_HUMAN ATP6AP1
52,009
99.50%
2
2
7
Actin-related protein 2/3 complex subunit 3 DAZ-associated protein 1
ARPC3_HUMAN ARPC3
20,530
100.00%
2
2
3
DAZP1_HUMAN DAZAP1
43,365
99.50%
2
2
4
60 kDa SS-A/Ro ribonucleoprotein
RO60_HUMAN TROVE2
60,654
100.00%
5
6
17
Syntenin-1
SDCB1_HUMAN SDCBP
32,427
100.00%
3
3
7
Uncharacterized protein LP9056
L9056_HUMAN LP9056
63,530
100.00%
5
5
32
EGF-containing fibulin-like extracellular matrix protein 1
FBLN3_HUMAN EFEMP1
54,621
100.00%
11
11
120
6.81% EVLTGNDEVIGQVLSTLK LGASPLHVDLATLR 13.50% DTDIVDEAIYYFK LIGNMALLPIR 7.62% LFVGGLDWSTTQETLR SQAPGQPGASQWGSR 10.80% ALLQEMPLTALLR LGLENAEALIR QIANSQDGYVWQVTDMNR SFSQEGR WRPDEEILK 21.50% DSTGHVGFIFK LYPELSQYMGLSLNEEEIR VIQAQTAFSANPANPAILSEASAPIPHDGNLYPR
9.24% ALFPSLGTYDLEK AMEQEFSATK GLLYQLFR KDHVLDIPTTQR VSSLASASR 23.10% ADQVCINLR ELPQSIVYK FSCMCPQGYQVVR GSFACQCPPGYQK IPSNPSHR LNCEDIDECR NNFVIR NPCQDPYILTPENR QTSPVSAMLVLVK RNPADPQR SGNENGEFYLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
52.8 67.4 79.1 31.0 51.8 40.5 57.3 86.3 64.7 69.5 26.8 73.3 58.2 43.0 106.0 36.7 51.5 110.0 45.0 43.6 47.4 73.2 39.7 68.1 61.2 112.0 77.4 77.3 72.8 75.2 35.8 55.3 36.1 90.3 36.5 48.7 66.7 39.7 29.2 75.0 49.2 35.7 58.7 84.6 45.5 53.9 35.2 63.8 76.1 35.9 53.4
22.6 20.5 21.5 20.9 20.9 20.5 21.3 23.2 22.0 21.4 22.5 21.7 21.6 19.4 21.4 12.8 23.2 17.8 20.3 22.4 19.8 19.2 18.3 22.2 15.1 21.8 21.3 16.3 21.6 21.4 20.8 21.6 22.0 22.1 18.8 22.2 21.4 19.1 20.8 23.3 23.4 21.8 17.2 17.2 22.9 13.4 23.7 21.3 19.8 22.2 19.7
2 2 2 1 6 2 3 7 9 7 0 10 1 1 8 1 4 3 0 2 0 5 0 1 2 2 2 8 4 1 1 2 4 2 0 9 10 5 0 7 3 1 2 14 13 1 3 9 58 2 14
0 0 2 0 3 0 9 0 0 0 1 0 0 0 0 0 0 0 1 0 2 0 2 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,025.51 1,357.62 1,786.83 822.37 1,888.00 1,014.43 1,767.92 1,547.77 1,582.81 1,240.65 1,088.54 1,177.65 1,713.80 1,183.65 2,068.06 1,161.46 1,138.58 2,263.98 3,255.52 1,333.62 2,867.48 1,915.04 1,462.84 1,591.75 1,210.73 1,822.93 1,513.71 1,468.86 1,198.68 2,124.98 810.37 1,185.63 1,207.61 2,300.11 3,530.80 1,453.76 1,141.52 1,009.58 1,422.77 877.47 1,088.55 1,076.60 1,647.71 1,499.64 907.48 1,323.53 762.43 1,716.80 1,372.79 953.49 1,285.58
Table S1 page 127/159
UPF0160 protein MYG1, mitochondrial 26S proteasome non-ATPase regulatory subunit 13
MYG1_HUMAN C12orf10
42,432
99.50%
2
2
4
PSD13_HUMAN PSMD13
42,901
100.00%
3
3
6
Acyl-coenzyme A thioesterase 1
ACOT1_HUMAN ACOT1
46,260
99.50%
2
2
4
Glutaminyl-tRNA synthetase
SYQ_HUMAN QARS
87,782
99.50%
2
2
6
Leucine-rich alpha-2-glycoprotein
A2GL_HUMAN LRG1
38,162
100.00%
3
3
15
Desmoglein-2
DSG2_HUMAN DSG2
122,276
100.00%
18
21
221
Beta-lactamase-like protein 2
LACB2_HUMAN LACTB2
32,789
100.00%
2
2
9
12,757
100.00%
6
6
11
SH3 domain-binding glutamic acid- SH3L1_HUMAN SH3BGRL rich-like protein
6.91% AMDLVQEEFLQR FQVDPSGEIVELAK 11.20% LNIGDLQVTK QMTDPNVALTFLEK TAWGQQPDLAANEAQLLR 7.36% DGYADIVDVLNSPLEGPDQK GPGVGLLGISK 2.58% FDDTNPEKEEAK LFTLTALR 11.00% DLLLPQPDLR TLDLGENQLETLPPDLLR VAAGAFQGLR 18.30% AWITAPVALR DGNGEVTDKPVK DNWISVDSVTSEIK EETPFFLLTGYALDAR GITEPPFGIFVFNK GNNVEKPLELR GQIIGNFQAFDEDTGLPAHAR ILDVNDNIPVVENK IVAISEDYPR IVAISEDYPRK IVSLEPAYPPVFYLNK LEDRDNWISVDSVTSEIK LPDFESR QAQVQIR QESTSVLLQQSEK QESTSVLLQQSEKK VLEGMVEENQVNVEVTR VVPSFLPVDQGGSLVGR 9.38% EQQILTLFR ILIDTGEPAIPEYISCLK 78.10% DIAANEENRK ENNAVYAFLGLTAPPGSK ENVPENSRPATGYPLPPQIFNESQYR
Hsc70-interacting protein
F10A1_HUMAN ST13
Nicotinate phosphoribosyltransferase PNCB_HUMAN NAPRT1
Matrix metalloproteinase-28
MMP28_HUMAN MMP28
Charged multivesicular body protein CHM4B_HUMAN CHMP4B 4b 4F2 cell-surface antigen heavy chain 4F2_HUMAN SLC3A2
41,314
100.00%
3
3
23
10.00%
57,561
100.00%
3
3
5
7.06%
58,923
99.50%
2
2
5
5.19%
24,933
99.50%
2
2
4
11.20%
67,978
100.00%
6
6
29
13.70%
GDYDAFFEAR QQDVLGFLEANK VYIASSSGSTAIK AIDLFTDAIK AIEINPDSAQPYK VAAIEALNDGELQK AAFVAYALAFPR LDSGDLLQQAQEIR SPAQYQVVLSER AFQWVSQLPVSGVLDR GGLQVEPYYPR EALENANTNTEVLK GGPTPQEAIQR ADLLLSTQPGREEGSPLELER GENSWFSTQVDTVATK GQSEDPGSLLSLFR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
83.4 42.0 42.0 55.7 106.0 91.8 62.2 36.9 46.2 35.7 66.7 74.9 38.5 56.6 56.2 43.0 79.7 56.4 119.0 82.4 68.1 30.1 54.9 83.2 34.5 37.0 99.2 38.8 76.8 55.9 55.8 64.9 35.3 52.7 53.1 41.3 77.8 45.2 57.5 53.8 109.0 30.0 87.6 65.9 71.0 52.3 45.0 45.9 37.2 56.3 85.3
22.5 23.6 21.5 22.9 21.7 22.0 14.6 20.5 14.9 19.0 20.0 22.0 18.1 22.4 23.1 22.1 20.4 21.5 21.2 20.9 23.2 21.6 18.6 22.7 24.0 20.0 22.9 22.3 22.5 19.5 20.4 21.7 22.3 22.0 20.1 16.3 23.9 21.5 22.0 23.0 21.8 19.5 22.0 22.6 21.4 22.3 23.0 22.8 20.8 21.3 22.7
2 2 3 2 1 2 2 2 4 2 7 6 5 4 4 1 17 6 4 35 12 0 44 4 3 2 10 2 28 2 7 2 1 2 0 2 2 2 10 3 10 1 2 2 2 3 2 2 0 2 12
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 18 0 0 1 0 16 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,494.73 1,531.80 1,100.63 1,622.81 1,982.01 2,145.04 997.60 1,422.64 934.57 1,179.67 2,037.09 989.55 1,097.65 1,258.63 1,592.78 1,842.93 1,565.84 1,268.70 2,257.10 1,581.85 1,162.61 1,290.71 1,850.01 2,106.04 863.43 842.48 1,476.75 1,604.85 1,944.97 1,726.95 1,147.65 2,032.07 1,159.57 1,848.95 3,003.46 1,190.51 1,361.71 1,283.68 1,106.61 1,445.73 1,470.78 1,296.71 1,585.82 1,376.72 1,801.96 1,278.65 1,545.78 1,153.60 2,310.19 1,769.83 1,505.76
Table S1 page 128/159
Mitotic checkpoint protein BUB3
BUB3_HUMAN BUB3
37,137
100.00%
6
6
9
19.80%
Serpin B6
SPB6_HUMAN SERPINB6
42,605
100.00%
6
7
45
23.40%
Splicing factor, arginine/serine-rich 6 SFRS6_HUMAN SFRS6
39,570
100.00%
5
5
21
14.00%
LDHB_HUMAN LDHB
36,621
100.00%
13
15
160
42.20%
Protein arginine N-methyltransferase ANM5_HUMAN PRMT5 5 U2 small nuclear ribonucleoprotein RU2A_HUMAN SNRPA1 A'
72,667
99.50%
2
2
4
3.61%
28,399
100.00%
3
3
6
15.70%
Sodium/potassium-transporting ATPase subunit alpha-1
AT1A1_HUMAN ATP1A1
112,882
100.00%
7
7
35
9.78%
Aminopeptidase B
AMPB_HUMAN RNPEP
72,579
100.00%
13
14
34
28.20%
L-lactate dehydrogenase B chain
LLTSFLPAQLLR VAEDEAEAAAAAK VILDLTPNYR LNQPPEDGISSVK LYDVPANSMR QGYVLSSIEGR QVTDAETKPK VAVEYLDPSPEVQK VLVWDLR ELNMIIMLPDETTDLR GNTAAQMAQILSFNK IAELLSPGSVDPLTR LVLVNAVYFR NLGMTDAFELGK SGGGGDIHQGFQSLLTEVNK ALDKLDGTEINGR LIEDKPR LIVENLSSR QAGEVTYADAHK VIVEHAR EKLIAPVAEEEATVPNNK FIIPQIVK GEMMDLQHGSLFLQTPK GLTSVINQK IVADKDYSVTANSK IVVVTAGVR LIAPVAEEEATVPNNK LKDDEVAQLK LKGEMMDLQHGSLFLQTPK LNLVQR MVVESAYEVIK SADTLWDIQK SLADELALVDVLEDK SLADELALVDVLEDKLK VIGSGCNLDSAR AAILPTSIFLTNK VPLVAPEDLR LTAELIEQAAQYTNAVR NAIANASTLAEVER SLTYLSILR AVFQANQENLPILK GVGIISEGNETVEDIAAR NMVPQQALVIR QGAIVAVTGDGVNDSPALK SPDFTNENPLETR TSATWLALSR VDNSSLTGESEPQTR AEFGPPGPGAGSR AFFPCFDTPAVK AIEAVAISPWK EEYNGVIEEFLATGEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
40.9 32.0 50.5 41.4 36.7 49.5 32.9 59.4 33.5 79.4 98.8 76.0 50.2 56.1 86.9 67.7 43.6 52.6 51.6 44.6 79.2 42.0 53.4 53.7 97.5 61.8 88.2 45.0 29.6 48.6 76.7 75.9 115.0 37.2 73.9 48.2 52.0 77.8 63.1 53.4 52.3 103.0 34.8 87.6 89.9 86.7 89.7 39.7 31.7 65.7 72.0
12.0 21.8 21.5 22.8 21.7 22.6 24.0 23.2 22.0 22.4 23.1 19.3 16.8 21.8 21.8 22.5 18.0 21.6 21.4 18.7 21.4 16.0 21.9 22.1 21.2 17.0 20.5 23.5 21.5 18.8 21.9 23.4 21.6 17.6 21.7 16.7 19.0 22.6 22.9 17.0 19.5 22.0 21.4 20.8 20.6 22.9 21.3 22.5 22.2 20.6 22.4
8 1 5 2 1 1 1 2 2 3 11 14 4 6 2 2 1 11 3 4 1 3 2 14 13 18 20 5 0 25 21 22 27 1 3 3 1 2 2 2 4 2 1 4 5 2 17 4 1 2 3
0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 6 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,371.84 1,245.60 1,203.67 1,383.71 1,181.56 1,208.63 1,116.59 1,573.81 900.53 1,935.94 1,593.81 1,567.87 1,193.70 1,295.63 2,044.01 1,401.73 870.51 1,030.59 1,289.61 823.48 1,952.03 957.61 1,963.93 959.55 1,510.78 913.58 1,694.90 1,158.64 2,205.11 742.46 1,267.66 1,176.59 1,629.86 1,871.04 1,248.60 1,388.82 1,108.64 1,890.99 1,458.76 1,065.63 1,584.88 1,829.92 1,284.71 1,811.95 1,519.70 1,105.60 1,619.75 1,199.58 1,399.67 1,184.67 1,827.87
Table S1 page 129/159
ETFASTASQLHSNVVNYVQQIVAPK
Delta-aminolevulinic acid dehydratase Eukaryotic translation initiation factor 3 subunit J
HEM2_HUMAN ALAD
36,277
99.50%
2
2
3
EIF3J_HUMAN EIF3J
29,045
100.00%
4
5
9
Aminoacylase-1
ACY1_HUMAN ACY1
45,866
100.00%
8
9
17
40S ribosomal protein SA
RSSA_HUMAN RPSA
32,836
100.00%
6
6
38
Actin-related protein 2/3 complex subunit 2
ARPC2_HUMAN ARPC2
34,316
100.00%
8
8
15
Thimet oligopeptidase
THOP1_HUMAN THOP1
78,823
100.00%
9
10
24
Protein disulfide-isomerase A6
PDIA6_HUMAN PDIA6
48,104
100.00%
6
6
19
IEPGVDPDDTYNETPYEK LGDTYPSISNAR QHMDITGEENPLNK RPLHSAQAVDVASASNFR TYQLVYFLDK VDIIPGFEFDR VKIEPGVDPDDTYNETPYEK YTLPLYHAMMGGSEVAQTLAK 9.09% AAVLEAMTAFR GSAADSEESPAIEAIHLLR 20.50% ETFGVNNAVYGIDAMNPSSR LQEESDLELAK RLEEPEEPK VLTPEEQLADKLR 28.70% AGFALDEGIANPTDAFTVFYSER AVGVPALGFSPMNR DMNLTLEPEIMPAATDNR EGSVTSVNLTK FMEDTAAEK GPEEEHPSVTLFR TVQPKPDYGAAVAFFEETAR VVNSILAFR 24.10% AIVAIENPADVSVISSR DPEEIEKEEQAAAEK FAAATGATPIAGR FTPGTFTNQIQAAFR KSDGIYIINLK SDGIYIINLK 25.00% ASHTAPQVLFSHR DNTINLIHTFR DSIVHQAGMLK ELQAHGADELLK ELQAHGADELLKR IIEETLALK MILLEVNNR NCFASVFEK 14.90% ETQENIKR FYLDLYPR LKPLGEQER NILDFPQHVSPSK QANTGLFNLR TSQTVATFLDELAQK VDQALHTQTDADPAEEYAR WDLSAQQIEER YYMNQVEETR 21.80% DGELPVEDDIDLSDVELDDLGKDEL GESPVDYDGGR GSTAPVGGGAFPTIVER LAAVDATVNQVLASR NLEPEWAAAASEVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
30.0 106.0 42.5 38.8 33.3 67.5 34.2 37.1 39.5 43.1 27.1 94.0 53.0 33.4 58.9 58.0 32.6 68.6 50.4 49.7 62.1 45.8 69.2 108.0 54.9 83.8 89.0 31.2 59.6 38.5 38.6 49.2 47.9 27.8 57.4 49.8 30.5 34.1 33.8 34.1 65.5 54.4 74.9 79.2 68.5 53.0 66.5 40.7 97.8 101.0 31.3
20.4 17.9 23.2 21.5 21.0 24.1 22.8 21.6 21.2 22.1 22.4 21.8 23.0 22.6 20.6 21.1 23.3 20.9 22.7 19.1 22.5 21.4 17.9 19.2 21.7 23.4 21.8 17.4 21.6 22.5 22.5 21.8 21.8 22.0 17.6 22.8 19.1 23.2 22.9 20.3 23.0 22.7 22.3 20.0 21.3 18.7 20.1 18.4 22.8 20.6 22.2
0 4 2 2 0 5 2 0 0 2 0 1 2 1 3 1 2 1 2 2 2 0 4 13 1 9 9 1 5 0 2 2 2 0 2 3 1 1 3 0 2 2 5 1 2 3 2 2 2 3 1
3 0 0 1 1 0 0 2 2 0 1 0 0 0 2 0 0 0 0 0 1 2 0 0 0 0 0 0 0 2 0 0 0 1 0 0 0 0 0 2 0 0 0 3 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,731.41 2,081.92 1,293.64 1,641.75 1,925.99 1,289.68 1,307.66 2,309.08 2,313.13 1,179.62 1,965.99 2,157.99 1,274.65 1,126.57 1,511.84 2,491.18 1,431.74 2,062.94 1,134.60 1,057.45 1,497.73 2,197.09 1,018.60 1,740.95 1,715.80 1,203.65 1,698.86 1,263.73 1,135.64 1,450.76 1,343.71 1,198.63 1,323.69 1,479.79 1,029.62 1,101.61 1,101.50 1,017.53 1,086.56 1,069.60 1,481.78 1,133.61 1,651.85 2,129.97 1,374.67 1,332.59 2,758.27 1,151.50 1,615.84 1,527.85 1,514.75
Table S1 page 130/159
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
ECH1_HUMAN ECH1
35,798
100.00%
5
5
15
Neuropilin-2
NRP2_HUMAN NRP2
104,843
100.00%
2
2
6
Antileukoproteinase
SLPI_HUMAN SLPI
14,308
100.00%
6
6
11
5'-nucleotidase
5NTD_HUMAN NT5E
63,351
99.50%
2
2
3
AP-2 complex subunit beta
AP2B1_HUMAN AP2B1
104,537
100.00%
3
3
8
Adenylate kinase isoenzyme 1
KAD1_HUMAN AK1
21,617
100.00%
5
5
9
Tumor protein D54
TPD54_HUMAN TPD52L2
22,220
100.00%
5
5
18
Ribulose-phosphate 3-epimerase
RPE_HUMAN RPE
24,910
99.50%
2
2
3
14-3-3 protein epsilon
1433E_HUMAN YWHAE
29,157
100.00%
19
24
347
TGEAIVDAALSALR 17.10% MMADEALGSGLVSR SPVAVQSTK VIGNQSLVNELAFTAR VNLLYSR YQETFNVIER 2.69% SGEIAIDDIR VFQANNDATEVVLNK 41.70% AGVCPPK CCMGMCGK CLDPVDTPNPTR SAQCLR SCVSPVK YKKPECQSDWQCPGK 4.18% FPILSANIK GPLASQISGLYLPYK 4.27% LASQANIAQVLAELK MEPLNNLQVAVK NVEGQDMLYQSLK 27.80% EVQQGEEFER GFLIDGYPR GQLVPLETVLDMLR IIFVVGGPGSGK VDDNEETIK 42.70% GLLSDSMTDVPVDTGVAAR LGLSTLGELK TPAVEGLTEAEEEELR TSAALSTVGSAISR VVGDRENGSDNLPSSAGSGDKPLSDPAPF
11.40% IGPSILNSDLANLGAECLR SVINLLR 71.00% AAFDDAIAELDTLSEESYK AASDIAMTELPPTHPIR DNLTLWTSDMQGDGEEQNK DNLTLWTSDMQGDGEEQNKEALQDVEDENQ
DSTLIMQLLR EAAENSLVAYK EALQDVEDENQ HLIPAANTGESK IISSIEQK IISSIEQKEENK KEAAENSLVAYK LAEQAER LAEQAERYDEMVESMK LICCDILDVLDK LICCDILDVLDKHLIPAANTGESK
NLLSVAYK QMVETELK VAGMDVELTVEER YDEMVESMK YDEMVESMKK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
97.7 98.7 53.3 79.9 47.9 32.0 51.3 72.3 43.4 50.6 66.8 37.9 36.6 45.6 31.9 33.4 58.9 46.1 53.5 43.2 38.9 64.7 58.8 47.9 103.0 59.0 62.3 70.1 32.2 91.9 35.0 121.0 81.8 115.0 76.9 79.3 67.4 65.5 54.5 48.1 76.5 58.1 59.4 49.0 78.4 34.9 51.4 58.5 104.0 49.6 34.3
22.3 21.5 23.0 20.6 20.7 21.9 23.8 22.7 21.0 0.0 21.9 23.8 25.0 19.9 17.6 19.3 17.6 22.3 22.3 21.2 22.1 20.2 18.7 21.2 22.2 17.9 21.6 22.2 20.0 20.9 21.0 20.9 22.0 18.2 15.2 21.3 23.2 17.1 22.5 22.6 22.6 22.0 21.6 20.1 23.3 20.2 19.1 24.0 22.5 13.0 17.9
9 6 2 2 4 1 4 2 2 3 2 1 1 0 2 1 2 4 2 2 2 3 1 1 4 8 1 4 0 2 1 21 36 7 0 113 31 5 4 8 8 5 36 1 16 0 49 19 63 11 1
0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 10 38 0 5 0 0 0 1 0 0 0 0 9 0 0 0 0 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,386.76 1,468.68 916.51 1,731.94 864.49 1,298.64 1,088.56 1,661.85 728.38 1,019.32 1,384.65 734.36 776.40 1,910.85 1,002.60 1,606.88 1,568.90 1,371.73 1,540.73 1,250.57 1,037.54 1,599.88 1,130.66 1,062.50 1,919.94 1,030.62 1,772.86 1,320.71 2,885.36 2,013.04 814.52 2,087.97 1,819.94 2,180.94 3,467.47 1,189.66 1,194.60 1,289.55 1,237.65 917.53 1,417.75 1,322.70 816.42 1,928.87 1,476.74 2,695.38 907.53 993.49 1,463.71 1,163.46 1,275.56
Table S1 page 131/159
YLAEFATGNDR YLAEFATGNDRK IADGYEQAAR QQISLATQMVR WVGGPEIELIAIATGGR FEHCNFNDVTTR LRENELTYYCCK EGPFGTLVYTIK WDQLTLSQR DTVIVWPR FYGSPEELAR VVQPTLEQTQYSWER HAETSSGGQAASSQEQAR LAQAYYESTR QGSSVSQDSDSEGHSEDSER
T-complex protein 1 subunit epsilon TCPE_HUMAN CCT5
59,654
100.00%
3
3
15
7.02%
CD59 glycoprotein
CD59_HUMAN CD59
14,159
99.50%
2
3
5
18.80%
Metalloproteinase inhibitor 3
TIMP3_HUMAN TIMP3
24,128
99.90%
2
2
6
9.95%
Amiloride-sensitive amine oxidase [copper-containing]
ABP1_HUMAN ABP1
85,360
100.00%
3
3
6
4.39%
Filaggrin
FILA_HUMAN FLG
435,128
100.00%
4
4
6
1.75%
Heat shock protein beta-1
HSPB1_HUMAN HSPB1
22,765
100.00%
11
11
69
59.00% AQLGGPEAAK GPSWDPFR
QSGTPHAETSSGGQAASSHEQAR
KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK
LATQSNEITIPVTFESR LFDQAFGLPR QLSSGVSEIR RVPFSLLR TKDGVVEITGK VPFSLLR VSLDVNHFAPDELTVK YTLPPGVDPTQVSSSLSPEGTLTVEAPMPK
Heterogeneous nuclear ribonucleoprotein F
HNRPF_HUMAN HNRNPF
45,654
100.00%
3
4
49
Proteasome subunit alpha type-1
PSA1_HUMAN PSMA1
29,538
100.00%
12
14
60
Ras-related protein Rab-14
RAB14_HUMAN RAB14
23,880
100.00%
9
9
21
15.90% ATENDIYNFFSPLNPVR HSGPNSADSANDGFVR ITGEAFVQFASQELAEK VHIEIGPDGR YIEVFK 44.10% AMSIGAR AQPAQPADEPAEK AQPAQPADEPAEKADEPMEH AQSELAAHQK ETLPAEQDLTTK IHQIEYAMEAVK LLCNFMR LVSLIGSK NQYDNDVTVWSPQGR NVSIGIVGK THAVLVALK TQIPTQR 54.00% ADLEAQR GAAGALMVYDITR IYQNIQDGSLDLNAAESGVQHKPSAPQGGR
LQIWDTAGQER NLTNPNTVIILIGNK STYNHLSSWLTDAR TGENVEDAFLEAAK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
62.7 55.1 91.7 59.0 33.8 65.5 45.6 55.4 43.7 49.4 34.0 84.4 40.3 40.0 30.5 18.6 54.9 33.8 75.0 80.1 86.6 61.5 37.1 28.2 49.2 70.7 37.4 74.0 98.5 111.0 44.3 32.9 44.8 60.4 75.1 33.8 66.5 44.1 34.3 55.4 86.6 46.5 36.8 33.5 63.8 48.8 41.0 61.5 53.4 30.4 85.2
21.1 22.4 23.5 23.1 19.8 17.8 20.6 20.6 23.9 21.0 22.6 22.4 20.1 21.5 12.8 19.1 20.5 21.3 19.5 21.2 22.3 23.6 15.8 22.1 19.3 21.7 20.7 22.4 19.3 21.4 22.2 19.7 23.7 21.7 17.8 21.2 23.0 22.7 22.3 17.2 24.9 21.7 13.4 22.7 22.0 22.5 20.6 22.2 15.3 22.3 22.9
21 19 12 2 1 2 2 4 2 2 2 2 0 2 0 0 5 2 0 11 21 4 2 0 3 8 0 23 8 36 3 2 3 10 5 2 6 6 1 3 12 3 1 3 3 1 0 7 3 0 2
0 0 0 0 0 1 0 0 0 0 0 0 2 0 1 0 0 0 11 0 0 0 0 1 0 0 1 1 3 0 1 0 0 0 0 0 0 4 0 0 1 0 0 0 0 0 0 0 0 1 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,256.59 1,384.69 1,093.53 1,290.68 1,738.95 1,539.67 1,648.75 1,324.72 1,146.59 985.55 1,168.56 1,863.92 1,801.81 1,201.59 2,122.84 2,281.02 941.51 961.45 3,242.65 1,905.99 1,163.62 1,075.57 987.61 1,146.64 831.51 1,783.92 3,114.56 1,996.98 1,630.72 1,867.94 1,092.58 798.44 721.37 1,351.65 2,176.95 1,082.56 1,345.69 1,447.73 953.47 816.52 1,778.81 886.54 951.60 843.47 802.41 1,337.69 3,150.56 1,316.66 1,623.94 1,650.79 1,493.71
Table S1 page 132/159
Vacuolar protein sorting-associated protein 26A
VP26A_HUMAN VPS26A
38,153
100.00%
11
11
26
GrpE protein homolog 1, mitochondrial
GRPE1_HUMAN GRPEL1
24,261
100.00%
3
3
6
3,2-trans-enoyl-CoA isomerase, mitochondrial
D3D2_HUMAN DCI
TGENVEDAFLEAAKK YIIIGDMGVGK 41.90% EITGIGPSTTTETETIAK ELALPGELTQSR EYDLIVHQLATYPDVNNSIK FESPESQASAEQPEM HYLFYDGESVSGK IQHMELQLIK LFLAGYDPTPTMR QQEIILWR SNTHEFVNLVK YEIMDGAPVK YEIMDGAPVKGESIPIR 21.20% DLLEVADVLEK NSGQNLEEDMGQSEQKADPPATEK
32,799
100.00%
5
5
16
Poliovirus receptor-related protein 1 PVRL1_HUMAN PVRL1
57,140
100.00%
4
5
71
Proteasome activator complex subunit 3
PSME3_HUMAN PSME3
29,489
100.00%
3
3
6
Importin subunit beta-1
IMB1_HUMAN KPNB1
97,153
100.00%
16
19
70
NADP-dependent malic enzyme
MAOX_HUMAN ME1
64,133
100.00%
5
6
11
WD repeat-containing protein 1
WDR1_HUMAN WDR1
66,175
100.00%
11
13
47
TLRPALVGVVK 16.90% AVQELWLR DADVQNFVSFISK ILADNPR SLQMYLER VLVEPDAGAGVAVMK 12.80% GPINYSLAGTYICEATNPIGTR LKGEAEYQEIR QNVAIYNPSMGVSVLAPYR VEFLRPSFTDGTIR 16.10% ITSEAEDLVANFFPK SNQQLVDIIEK TVESEAASYLDQISR 25.70% AAVENLPTFLVELSR ANFDKESER ESCLEAYTGIVQGLK GALQYLVPILTQTLTK GDQENVHPDVMLVQPR LAATNALLNSLEFTK LLETTDRPDGHQNNLR LQQVLQMESHIQSTSDR SDYDMVDYLNELR SNEILTAIIQGMR SSAYESLMEIVK TVSPDRLELEAAQK VAALQNLVK VLANPGNSQVAR YLEVVLNTLQQASQAQVDK YMEAFKPFLGIGLK 16.10% DMAAFNERPIIFALSNPTSK GSEYDDFLDEFMEAVSSK QITDNIFLTTAEVIAQQVSDK QQLNIHGLLPPSFNSQEIQVLR TATVYPEPQNK 24.40% AHDGGIYAISWSPDSTHLLSASGDK DYSGQGVVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
34.8 36.2 75.6 67.2 68.4 49.0 44.3 28.0 67.8 45.7 34.4 34.0 36.3 70.7 36.4 34.4 49.6 103.0 38.4 44.7 76.3 96.7 61.0 125.0 57.0 57.0 31.6 82.1 90.6 56.2 68.9 51.9 48.5 110.0 32.9 27.4 77.4 72.8 51.5 38.0 45.7 79.6 115.0 28.4 49.7 94.9 127.0 33.2 45.0 49.5 41.0
22.2 22.3 22.1 21.9 20.6 14.6 22.0 19.3 22.5 22.1 22.5 22.2 22.5 22.2 18.5 7.0 22.3 22.2 19.4 22.0 20.8 21.9 22.8 20.7 21.5 22.7 22.7 21.8 19.7 21.3 22.2 12.0 22.0 20.1 22.5 22.1 18.6 22.5 21.4 21.9 16.9 21.5 20.3 21.3 21.9 15.1 19.8 17.3 23.2 21.6 21.8
0 1 5 5 1 3 1 0 4 2 0 1 0 2 0 0 2 4 2 6 2 1 13 31 0 3 1 2 12 2 2 5 2 15 1 0 2 6 3 2 3 6 2 0 0 2 2 0 2 0 1
2 0 0 0 0 0 0 1 0 0 1 0 2 0 2 2 0 0 0 0 0 0 4 0 22 0 0 0 2 0 0 0 2 0 1 1 0 0 0 0 0 0 0 1 2 0 2 1 0 3 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,621.81 1,181.62 1,848.94 1,313.71 2,332.18 1,682.69 1,501.70 1,252.71 1,497.74 1,085.61 1,287.67 1,138.55 1,890.96 1,243.68 2,619.15 1,152.75 1,014.57 1,469.73 798.45 1,055.52 1,455.79 2,368.16 1,335.69 2,079.07 1,637.87 1,680.85 1,286.70 1,668.81 1,658.91 1,095.51 1,667.83 1,759.04 1,849.89 1,605.89 1,878.94 2,015.98 1,632.72 1,445.78 1,372.67 1,556.83 955.59 1,225.67 2,147.14 1,629.87 2,238.12 2,084.86 2,334.22 2,531.37 1,247.63 2,585.23 952.47
Table S1 page 133/159
Latent-transforming growth factor beta-binding protein 4
LTBP4_HUMAN LTBP4
173,410
100.00%
19
21
186
FATASADGQIYIYDGK IIGGDPK KVFASLPQVER LATGSDDNCAAFFEGPPFK LYSILGTTLKDEGK NIDNPALADIYTEHAHQVVVAK VFASLPQVER YAPSGFYIASGDVSGK YEYQPFAGK 14.50% AEAAAPYTVLAQSAPR CSCAPGYR DGGCSLPILR DVDECQLFR EDGYSDASGFGYCFR EICPAGPGYHYSASDLR GCQLCPPFGSEGFR GGYTCVCPDGFLLDSSR GYLAPSGDLSLR LSPQGTR NPQVCGPGR QICCCSR RVPPPCAPGR SSCISQHVISEAK TQEVCCR TSAGTFPGSQPQAPASPVLPARPPPPPLPR
Alpha-actinin-1
ACTN1_HUMAN ACTN1
103,043
100.00%
30
39
368
VPPPCAPGR VSGPWEEADAEAVAR VSLSQPR YNTRPLGQEPPR 67.60% AGTQIENIEEDFR AGTQIENIEEDFRDGLK AIMTYVSSFYHAFSGAQK ALDFIASK ASIHEAWTDGK ATLPDADKER CQLEINFNTLQTK DDPLTNLNTAFDVAEK DHSGTLGPEEFK DLLLDPAWEK DQALTEEHAR DYETATLSEIK EGLLLWCQR ELPPDQAEYCIAR ETADTDTADQVMASFK FAIQDISVEETSAK GISQEQMNEFR GYEEWLLNEIR HEAFESDLAAHQDR HRPELIDYGK HTNYTMEHIR ICDQWDNLGALTQK
95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
80.4 31.8 26.5 83.3 77.0 35.5 46.9 80.0 35.4 122.0 47.7 41.3 37.5 85.8 64.9 58.0 91.9 33.3 32.3 49.8 34.2 38.6 27.5 34.8 63.2 31.6 99.1 44.1 38.4 71.5 79.1 87.6 64.7 48.0 51.9 92.7 101.0 30.8 50.4 52.5 64.5 48.2 73.8 121.0 104.0 52.0 101.0 51.6 44.5 41.5 105.0
22.5 18.8 20.4 19.3 19.2 21.1 22.7 22.1 21.7 22.8 14.9 23.1 20.5 13.0 20.6 18.9 18.8 22.9 22.6 19.9 13.0 23.3 21.4 16.6 16.9 22.7 22.0 23.1 23.0 21.9 22.1 22.3 21.2 20.6 21.9 22.9 22.9 20.4 22.0 22.3 22.6 23.4 21.1 17.8 22.3 19.9 23.5 20.1 21.8 20.6 21.8
12 2 0 3 4 0 4 8 3 30 2 18 1 3 2 12 5 1 2 6 1 0 0 1 0 1 29 12 1 4 4 31 17 20 16 4 10 1 7 4 3 26 14 26 225 18 73 0 0 0 4
0 0 1 0 3 1 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 1 1 0 42 0 0 0 4 0 7 13 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 4 29 15 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,719.82 699.40 1,273.73 2,043.91 1,537.85 2,418.24 1,145.63 1,618.78 1,102.52 1,615.84 970.39 1,087.56 1,181.53 1,730.68 1,892.86 1,611.71 1,903.83 1,248.66 758.42 984.47 983.39 1,106.59 1,445.71 952.40 2,988.61 950.49 1,586.75 786.45 1,427.74 1,521.72 1,934.95 2,023.96 864.48 1,214.58 1,115.57 1,608.81 1,762.85 1,316.61 1,199.63 1,169.56 1,269.62 1,174.60 1,561.73 1,745.75 1,537.78 1,354.61 1,421.71 1,625.73 1,227.65 1,301.61 1,661.80
Table S1 page 134/159
IDQLEGDHQLIQEALIFDNK ILAGDKNYITMDELR IMSIVDPNR ISIEMHGTLEDQLSHLR IVQTYHVNMAGTNPYTTITPQEINGK
KDDPLTNLNTAFDVAEK KHEAFESDLAAHQDR LAILGIHNEVSK LASDLLEWIR LDHLAEK LLETIDQLYLEYAK LMLLLEVISGER LSNRPAFMPSEGR LVSIGAEEIVDGNVK MEEIGR MLDAEDIVGTARPDEK MTLGMIWTIILR MVSDINNAWGCLEQVEK QFGAQANVIGPWIQTK QKDYETATLSEIK RDQALTEEHAR TFTAWCNSHLR TINEVENQILTR TIPWLENR VEQIAAIAQELNELDYYDSPSVNAR
Filamin-A
FLNA_HUMAN FLNA
280,711
100.00%
72
88
1231
VGWEQLLTTIAR VLAVNQENEQLMEDYEK VPENTMHAMQQK YLDIPK 39.60% AEGPGLSR AFGPGLQGGSAGSPAR AGGPGLER AGNNMLLVGVHGPR AGQSAAGAAPGGGVDTR AHVVPCFDASK ALTQTGGPHVK ANLPQSFQVDTSK ASGPGLNTTGVPASLPVEFTIDAK
ATCAPQHGAPGPGPADASK AWGPGLEGGVVGK AYGPGIEPTGNMVK CSGPGLER DAGEGLLAVQITDPEGKPK DAPQDFHPDR DLAEDAPWK DLAEDAPWKK DVDIIDHHDNTYTVK EAGAGGLAIAVEGPSK EATTEFSVDAR EGPYSISVLYGDEEVPR ENGVYLIDVK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
100.0 30.4 41.5 32.2 52.3 104.0 48.4 55.3 101.0 45.8 81.6 43.2 38.1 123.0 30.8 83.3 97.4 114.0 80.2 70.0 58.8 33.2 86.4 36.2 75.6 92.8 136.0 40.7 35.7 47.3 96.4 79.5 59.6 90.0 32.3 44.4 73.7 90.5 42.9 76.9 65.6 52.7 99.3 40.3 31.6 40.9 48.7 90.2 85.5 100.0 36.9
21.2 21.4 22.9 21.8 20.8 22.1 21.5 16.9 22.0 19.3 19.8 19.6 23.5 21.4 23.0 22.3 20.2 20.4 20.9 22.2 22.2 22.0 22.5 20.3 22.0 20.5 21.1 20.6 19.0 20.5 22.4 20.7 22.7 21.9 22.1 21.2 23.0 20.0 21.6 21.7 22.4 20.5 21.1 20.0 20.5 22.5 22.5 21.6 20.8 22.3 22.8
4 0 8 0 0 8 0 6 38 13 10 1 1 72 3 12 49 5 13 7 1 1 61 2 1 180 15 6 14 9 46 30 0 30 1 21 50 30 0 32 46 6 13 7 1 2 4 15 25 39 4
16 2 0 2 3 7 6 0 0 0 0 0 6 0 0 10 0 0 0 2 13 0 0 0 6 0 0 0 0 0 0 0 26 0 0 0 0 1 5 0 0 0 8 3 0 0 0 0 0 0 0
0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,339.19 1,751.90 1,044.55 1,995.00 2,890.44 1,890.95 1,753.83 1,293.75 1,215.67 825.45 1,711.92 1,388.78 1,477.72 1,542.84 734.35 1,775.85 1,479.81 2,008.91 1,757.93 1,525.78 1,325.66 1,392.65 1,429.77 1,028.55 2,808.37 1,386.77 2,067.95 1,429.66 748.42 786.41 1,429.72 756.40 1,450.76 1,442.70 1,230.59 1,108.61 1,434.72 2,342.22 1,789.83 1,226.65 1,433.71 875.40 1,938.02 1,197.53 1,044.50 1,172.60 1,784.85 1,426.75 1,225.57 1,909.92 1,149.62
Table S1 page 135/159
FGGEHVPNSPFQVTALAGDQPSVQPPLR
FNEEHIPDSPFVVPVASPSGDAR FTVETR FVPAEMGTHTVSVK GAGTGGLGLAVEGPSEAK GKLDVQFSGLTK GLVEPVDVVDNADGTQTVNYVPSR
GQHVPGSPFQFTVGPLGEGGAHK
GTVEPQLEAR IANLQTDLSDGLR IPEISIQDMTAQVTSPSGK IQQNTFTR KGEITGEVR LDVQFSGLTK LIALLEVLSQK LLGWIQNK LPQLPITNFSR LSPFMADIR LTVSSLQESGLK LVSNHSLHETSSVFVDSLTK LYSVSYLLK NDNDTFTVK NGHVGISFVPK SAGQGEVLVYVEDPAGHQEEAK
SPFEVYVDK SPFEVYVDKSQGDASK SPFSVAVSPSLDLSK SPYTVTVGQACNPSACR TFSVWYVPEVTGTHK TGVAVNKPAEFTVDAK TGVELGKPTHFTVNAK TPCEEILVK VANPSGNLTETYVQDR VAQPTITDNKDGTVTVR VDVGKDQEFTVK VEPGLGADNSVVR VGSAADIPINISETDLSLLTATVVPPSGR
VHGPGIQSGTTNKPNK VKAEGPGLSR VKETADFK VKVEPSHDASK VLPTHDASK VNQPASFAVSLNGAK VNVGAGSHPNK VPVHDVTDASK VQVQDNEGCPVEALVK VTAQGPGLEPSGNIANK VTVLFAGQHIAK VTYTPMAPGSYLISIK WGDEHIPGSPYR YAPSEAGLHEMDIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
63.0 53.4 33.4 37.9 98.9 38.5 117.0 20.8 58.9 116.0 107.0 42.6 40.9 57.7 65.7 65.3 53.8 46.8 76.2 52.3 37.0 34.9 29.6 65.6 64.4 68.7 75.4 67.2 42.2 84.4 26.9 41.3 120.0 72.0 64.8 58.5 31.6 53.9 47.0 32.1 43.2 44.2 67.2 57.0 58.0 101.0 102.0 69.2 67.7 42.2 52.8
20.3 22.1 20.3 22.8 22.4 20.4 21.5 21.9 22.7 21.5 21.8 22.3 23.4 22.2 13.4 22.2 20.0 23.2 21.5 21.2 21.5 20.3 20.8 21.5 21.8 21.7 21.7 20.3 22.5 21.7 20.8 23.2 22.7 21.5 22.9 22.5 15.8 22.1 18.9 20.9 21.7 19.8 22.8 22.6 22.6 22.5 21.9 17.9 21.6 21.2 21.3
0 0 2 2 37 1 15 0 25 60 11 12 2 4 17 37 22 15 10 0 4 2 0 0 29 1 37 1 2 17 0 2 36 15 20 11 0 4 17 1 0 2 4 5 27 12 60 11 41 1 6
22 17 0 0 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 18 0 5 0 0 11 16 1 0 0 9 5 0 2 3 0 0 2 0 0 1 13 0 0 1 0 2 0
0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,945.49 2,467.19 752.39 1,518.76 1,570.81 1,292.72 2,544.26 2,304.15 1,099.57 1,415.75 2,002.02 1,007.53 988.54 1,107.61 1,226.77 971.57 1,285.73 1,049.55 1,261.70 2,200.13 1,085.62 1,053.49 1,154.63 2,313.10 1,083.54 1,756.84 1,533.82 1,867.84 1,750.88 1,646.88 1,698.92 1,088.57 1,763.86 1,814.96 1,364.71 1,312.69 2,893.55 1,634.86 1,013.57 937.50 1,196.63 967.52 1,502.80 1,079.56 1,167.60 1,784.89 1,652.86 1,283.75 1,756.92 1,413.66 1,604.74
Table S1 page 136/159
Receptor-type tyrosine-protein phosphatase F
PTPRF_HUMAN PTPRF
212,860
100.00%
20
21
103
12.90%
Glutathione S-transferase omega-1
GSTO1_HUMAN GSTO1
27,549
100.00%
8
8
58
34.90%
Structural maintenance of chromosomes protein 3
SMC3_HUMAN SMC3
141,529
100.00%
8
8
14
8.87%
Nuclear ubiquitous casein and cyclin-dependent kinases substrate
NUCKS_HUMAN NUCKS1
27,279
100.00%
5
5
8
21.80%
Glucosamine 6-phosphate Nacetyltransferase
GNA1_HUMAN GNPNAT1
20,731
100.00%
4
4
14
31.50%
14-3-3 protein sigma
1433S_HUMAN SFN
27,757
100.00%
14
18
282
63.70%
YGGDEIPFSPYR YGGPYHIGGSPFK YGGQPVPNFPSK YNEQHVPGSPFTAR YTPVQQGPVGVNVTYGGDPIPK AAGTEGPFQEVDGVATTR AGLGEEFEK AHTDVGPGPESSPVLVR EHSSWDLVGLEK FEVIEFDDGAGSVLR GPPSEAVR GSGPLSPSIQSR GSSAGGLQHLVSIR LENGEPR NVLELSNVVR SDMGVGVFTPTIEAR TAQSTPSAPPQK TDEDVPSGPPR TGEQAPSSPPR TGEQAPSSPPRR TQQGVPAQPADFQAEVESDTR VGGSMLTPR VLAFTAVGDGPPSPTIQVK YSAPANLYVR YSIGGLSPFSEYAFR EDPTVSALLTSEK EFTKLEEVLTNK GSAPPGPVPEGSIR HEVININLK LNECVDHTPK MILELFSK NKPEWFFK VPSLVGSFIR ALDQFVNFSEQK EENAEQQALAAK ELGSLPQEAFEK GALTGGYYDTR GSGSQSSVPSVDQFTGVGIR INQMATAPDSQR KGDVEGSQSQDEGEGSGESER LAQATQER ATVTPSPVK LKATVTPSPVK NSQEDSEDSEDKDVK VGRPTASK VVDYSQFQESDDADEDYGR ITLECLPQNVGFYK LLLSTLTLLSK MKPDETPMFDPSLLK VLGQLTETGVVSPEQFMK DSTLIMQLLR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
71.6 27.3 51.9 48.2 101.0 116.0 52.7 68.7 33.0 106.0 43.1 38.6 65.2 30.5 58.2 71.2 43.4 39.8 71.1 45.9 93.1 48.4 82.1 52.5 55.8 76.8 81.8 72.9 49.5 53.2 40.4 30.5 54.3 76.7 59.8 42.4 50.4 82.5 57.7 56.2 34.4 38.1 41.0 67.6 33.4 125.0 49.5 65.6 31.1 102.0 79.3
20.3 22.8 22.1 22.1 20.5 22.8 22.0 22.1 21.9 22.4 20.2 22.2 21.1 20.5 22.0 22.6 21.8 21.4 22.2 22.0 20.8 24.0 18.0 23.1 22.6 23.7 21.6 23.0 18.8 21.0 19.2 21.8 18.8 23.2 21.6 22.4 21.0 21.7 22.0 15.3 22.9 19.2 17.1 16.5 24.0 12.8 21.6 6.0 22.1 21.9 21.3
19 0 27 5 24 11 2 2 0 5 2 3 2 1 8 6 8 3 20 0 2 4 11 5 2 4 2 7 21 4 8 0 10 1 2 1 1 2 4 0 1 2 1 1 2 2 2 5 1 6 113
0 2 0 12 10 0 0 3 1 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,400.65 1,379.68 1,290.65 1,602.77 2,286.18 1,805.87 979.47 1,717.89 1,399.69 1,653.81 812.43 1,185.62 1,381.76 814.41 1,142.65 1,595.77 1,212.62 1,169.54 1,126.55 1,282.65 2,274.06 933.48 1,897.04 1,153.60 1,693.82 1,389.71 1,450.78 1,320.69 1,079.62 1,212.57 980.55 1,095.56 1,074.63 1,425.70 1,301.63 1,347.68 1,173.55 1,964.97 1,347.63 2,166.90 916.49 899.52 1,140.70 1,724.71 815.47 2,237.91 1,681.86 1,201.78 1,780.85 1,979.02 1,189.66
Table S1 page 137/159
Integrin beta-1
ITB1_HUMAN ITGB1
88,397
100.00%
7
8
33
Adenylate kinase 2, mitochondrial
KAD2_HUMAN AK2
26,461
100.00%
6
6
18
96,007
100.00%
12
12
36
Programmed cell death 6-interacting PDC6I_HUMAN PDCD6IP protein
EMPPTNPIR GAVEKGEELSCEER GEELSCEER KEMPPTNPIR LAEQAER LAEQAERYEDMAAFMK MKGDYYR NLLSVAYK NLLSVAYKNVVGGQR SAYQEAMDISK SAYQEAMDISKK SNEEGSEEKGPEVR TTFDEAMADLHTLSEDSYK VETELQGVCDTVLGLLDSHLIK VLSSIEQK YEDMAAFMK YLAEVATGDDK YLAEVATGDDKK 9.90% IGFGSFVEK LKPEDITQIQPQQLVLR SAVTTVVNPK SGEPQTFTLK SLGTDLMNEMR TVMPYISTTPAK WDTGENPIYK 31.00% APSVPAAEPEYPK AVLLGPPGAGK LQAYHTQTTPLIEYYR LVSDEMVVELIEK NGFLLDGFPR QAEMLDDLMEK 18.40% ELPELLQR EPSAPSIPTPAYQSSPAGGHAPTPPTPAPR
FYNELTEILVR KADLVNR LALASLGYEK LANQAADYFGDAFK LLDEEEATDNDLR NLATAYDNFVELVANLK SLLSNLDEVKK SVIEQGGIQTVDQLIK TMQGSEVVNVLK YYDQICSIEPK Arylsulfatase A
ARSA_HUMAN ARSA
53,571
99.50%
2
2
3
Activated RNA polymerase II transcriptional coactivator p15
TCP4_HUMAN SUB1
14,378
100.00%
6
6
11
8.09% DPGENYNLLGGVAGATPEVLQALK GGLPLEEVTVAEVLAAR 35.40% EQISDIDDAVR EQISDIDDAVRK EYWMDPEGEMKPGR GISLNPEQWSQLK GISLNPEQWSQLKEQISDIDDAVR
VLIDIR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
50.8 66.0 40.6 34.0 59.4 67.8 42.7 51.4 56.6 75.3 78.9 105.0 92.6 32.9 65.9 57.4 95.4 51.0 53.2 60.0 55.8 34.7 42.8 32.1 34.3 62.1 39.9 34.0 93.3 68.0 47.0 64.8 57.3 66.8 34.5 47.8 74.3 110.0 72.6 43.8 115.0 68.6 48.0 70.5 70.8 62.8 34.8 32.7 69.9 56.6 38.7
21.8 20.0 15.2 21.7 21.6 19.9 19.2 19.1 18.5 20.7 21.7 19.0 18.7 19.3 22.9 15.9 21.9 22.4 21.5 12.3 23.8 24.0 22.1 22.2 21.7 22.3 11.8 21.5 22.3 23.1 20.2 17.8 20.2 21.1 24.0 21.2 21.4 20.9 20.8 20.3 18.5 23.4 21.6 20.1 18.1 22.3 22.6 16.5 22.1 21.7 19.0
13 2 2 3 36 5 6 49 1 24 28 39 31 0 27 36 13 6 13 2 4 3 3 2 1 2 1 0 6 4 2 4 0 2 1 2 4 5 2 2 6 3 2 1 2 2 1 0 3 0 1
0 0 0 2 0 6 0 0 0 0 0 50 20 1 0 0 0 0 0 5 0 0 0 0 0 0 0 3 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,054.54 1,592.72 1,108.46 1,198.63 816.42 1,934.86 932.43 907.53 1,617.91 1,242.57 1,370.66 1,546.70 2,173.96 2,439.28 903.52 1,105.47 1,181.57 1,309.66 983.52 2,019.16 1,015.58 1,107.57 1,266.58 1,308.69 1,222.57 1,355.68 979.59 1,997.01 1,519.79 1,135.59 1,322.60 997.57 2,936.45 1,396.75 815.47 1,064.60 1,530.72 1,532.71 1,894.99 1,245.71 1,727.95 1,320.68 1,415.65 2,426.26 1,723.96 1,260.61 1,388.70 1,756.73 1,499.79 2,741.38 728.47
Table S1 page 138/159
Peptidyl-prolyl cis-trans isomerase FKBP3
FKBP3_HUMAN FKBP3
25,159
100.00%
6
6
18
Eukaryotic translation initiation factor 3 subunit F
EIF3F_HUMAN EIF3F
37,546
100.00%
3
3
7
Protein disulfide-isomerase
PDIA1_HUMAN P4HB
57,100
100.00%
31
40
314
30.80% AWTVEQLR FLQEHGSDSFLAEHK GWDEALLTMSK SEETLDEGPPK SEQLPK TANKDHLVTAYNHLFETK 10.90% FLMSLVNQVPK VIGLSSDLQQVGGASAR VIGTLLGTVDK 60.40% AEGSEIR EADDIVNWLK EADDIVNWLKK ENLLDFIK FFPASADR HNQLPLVIEFTEQTAPK IKPHLMSQELPEDWDKQPVK ILEFFGLK ILEFFGLKK ILFIFIDSDHTDNQR ITEFCHR KEECPAVR KFDEGR KSNFAEALAAHK LGETYKDHENIVIAK LITLEEEMTK LKAEGSEIR MDSTANEVEAVK NFEDVAFDEK NFEDVAFDEKK NNFEGEVTK NNFEGEVTKENLLDFIK QFLQAAEAIDDIPFGITSNSDVFSK
QLAPIWDK SNFAEALAAHK TGPAATTLPDGAAAESLVESSEVAVIGFFK
Protein DJ-1
PARK7_HUMAN PARK7
19,873
100.00%
11
13
65
THILLFLPK TVIDYNGER VDATEESDLAQQYGVR YKPESEELTAER YQLDKDGVVLFK 49.70% ALVILAK DGLILTSR EGPYDVVVLPGGNLGAQNLSESAAVK
EILKEQENR GAEEMETVIPVDVMR GAEEMETVIPVDVMRR KEGPYDVVVLPGGNLGAQNLSESAAVK
VEKDGLILTSR VTTHPLAK VTVAGLAGK VTVAGLAGKDPVQCSR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0%
45.8 31.8 74.3 50.0 32.8 35.7 81.3 100.0 74.5 49.2 62.6 46.8 54.5 40.6 62.5 36.0 53.7 39.9 70.7 52.9 51.2 43.0 37.7 36.4 71.1 38.5 84.2 55.4 48.7 30.9 80.7 44.3 45.8 54.1 64.6 38.1 32.4 115.0 61.6 65.2 57.7 42.4 64.7 45.3 68.7 44.0 34.1 33.5 32.5 30.1 40.3
23.3 21.7 22.4 20.3 21.1 22.0 20.9 21.3 19.2 23.9 22.6 22.5 20.7 21.8 19.9 20.3 18.3 16.3 21.8 21.8 21.9 23.7 23.2 21.8 23.0 23.7 20.8 19.3 21.4 22.4 21.4 21.6 19.7 22.6 20.0 12.0 22.7 22.0 22.5 20.7 11.8 24.1 20.8 24.0 23.2 22.0 18.2 20.4 16.0 21.0 21.4
2 0 5 2 1 0 3 2 2 2 21 2 20 1 11 0 14 2 2 5 2 1 0 2 14 2 26 4 9 1 3 3 2 4 0 6 2 26 11 7 15 7 6 4 18 0 0 1 1 1 0
0 4 0 0 0 0 0 0 0 0 0 0 0 0 41 0 0 0 2 0 0 0 2 11 0 0 0 0 0 0 6 1 0 0 9 5 0 2 4 10 0 0 3 1 0 5 1 0 0 0 2
0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,002.54 1,744.83 1,250.61 1,201.56 701.38 2,102.07 1,291.71 1,657.89 1,115.67 761.38 1,202.61 1,330.70 991.55 910.44 1,965.04 2,418.25 966.57 1,094.66 1,833.91 962.45 988.49 751.37 1,286.69 1,729.91 1,222.62 1,002.56 1,309.59 1,213.54 1,341.63 1,037.49 2,010.02 2,713.34 970.54 1,158.59 2,935.49 1,081.68 1,066.52 1,780.84 1,451.70 1,424.78 727.51 874.50 2,584.33 1,158.61 1,707.79 1,863.89 2,712.42 1,230.71 866.51 815.50 1,657.87
Table S1 page 139/159
Putative hydroxypyruvate isomerase HYI_HUMAN
HYI
30,388
100.00%
4
4
7
Selenium-binding protein 1
SBP1_HUMAN SELENBP1
52,374
99.90%
2
2
3
Heterogeneous nuclear ribonucleoprotein A3
ROA3_HUMAN HNRNPA3
39,577
100.00%
3
3
17
Osteoclast-stimulating factor 1
OSTF1_HUMAN OSTF1
23,770
100.00%
3
4
7
Glycogen phosphorylase, brain form PYGB_HUMAN PYGB
96,680
100.00%
10
10
28
BGH3_HUMAN TGFBI
74,665
100.00%
21
25
175
Transforming growth factor-betainduced protein ig-h3
21.70% AEMEAVFLENLR EFLPIVGHVQVAQVPGR GDTVEGLSWLR ITDPQYFLDTPQQAAAILQK 6.57% GGPVQVLEDEELK NTGTEAPDYLATVDVDPK 10.30% EDSVKPGAHLTVK IETIEVMEDR IFVGGIK IFVGGIKEDTEEYNLR 20.10% DIVEMLFTQPNIELNQQNK GYADIVQLLLAK LGDTALHAAAWK 14.90% GLAGLGDVAEVR IGEEFLTDLSQLK IGEEFLTDLSQLKK IVNGWQVEEADDWLR LLPLVSDEVFIR LQDFNVGDYIEAVLDR LVTSIGDVVNHDPVVGDR VAIQLNDTHPALSIPELMR VIFLENYR VLYPNDNFFEGK 33.70% DGTPPIDAHTR DLLNNHILK EGVYTVFAPTNEAFR ELANILK FSMLVAAIQSAGLTETLNR GDELADSALEIFK ILGDPEALR ILGDPEALRDLLNNHILK IPSETLNR LTLLAPLNSVFK NHIIKDQLASK NNVVSVNK NNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQER
Serine/threonine-protein phosphatase 2ABA_HUMAN PPP2R2A 2A 55 kDa regulatory subunit B alpha isoform ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1
51,675
100.00%
3
3
6
107,220
100.00%
18
18
46
QAGLGNHLSGSER QASAFSR SPYQLVLQHSR VLTDELK VLTPPMGTVMDVLK YGTLFTMDR YLYHGQTLETLGGK YLYHGQTLETLGGKK 8.05% LFEEPEDPSNR SFFSEIISSISDVK VVIFQQEQENK 21.50% ASLINNAFQLVSIGK DMNEVETQFK EMFDDVSYDK ESALLFDAEK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
32.3 35.3 56.8 88.9 64.2 64.1 30.6 66.0 34.6 46.2 78.9 75.4 46.0 74.4 70.1 43.6 98.5 64.5 119.0 38.7 31.6 50.2 55.6 36.2 35.4 66.1 37.3 107.0 90.6 60.2 27.1 56.0 60.9 42.1 33.5 39.0 56.8 41.4 71.6 33.1 47.0 63.2 66.3 52.3 60.9 65.2 66.3 101.0 34.8 30.8 45.3
21.9 16.4 23.3 19.9 22.3 22.2 21.4 23.0 16.5 21.4 22.3 16.7 21.6 21.4 22.6 20.4 22.0 18.3 22.1 21.8 19.3 21.6 21.8 23.3 18.0 21.8 20.0 21.1 22.4 18.4 14.1 21.6 12.0 18.9 24.0 15.8 22.4 21.1 21.4 23.0 22.7 21.3 22.6 20.3 20.4 23.5 23.8 17.8 19.0 15.7 23.4
1 0 2 2 1 2 1 14 1 2 2 2 2 2 3 0 2 3 3 0 0 5 3 3 1 20 4 14 30 7 0 7 13 2 1 0 5 4 7 2 10 10 5 0 2 2 2 3 2 1 2
0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 4 1 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 4 0 8 0 0 0 6 2 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,437.70 1,846.03 1,232.63 2,261.18 1,412.73 1,905.91 1,380.75 1,234.60 733.46 1,882.96 2,274.14 1,303.76 1,253.66 1,156.63 1,492.79 1,620.89 1,829.88 1,400.82 1,866.92 1,891.99 2,134.13 1,053.57 1,442.70 1,179.58 1,079.62 1,700.83 800.49 2,038.06 1,407.70 983.55 2,044.16 929.51 1,315.80 1,266.72 873.48 4,362.26 1,325.66 766.38 1,327.71 817.47 1,532.81 1,103.52 1,579.81 1,707.91 1,332.61 1,558.80 1,361.71 1,574.89 1,256.55 1,248.51 1,122.57
Table S1 page 140/159
Histone H2A type 1-D
H2A1D_HUMAN HIST1H2AD
14,090
100.00%
2
3
21
Laminin subunit beta-3
LAMB3_HUMAN LAMB3
129,553
100.00%
31
39
345
FELGSSSIAHMVMGTTNQFSTR GFPLITITVR GTHTAVSSNDR HLAISNMPLVK ILASTQFEPTAAR NPVGYPLAWQFLR QTWTDEGSVSER SDGTPFPWNK SGIVQYLQK TDVLILPEEVEWIK TKTDVLILPEEVEWIK TQEFPQILTLIGR VGDYFFGK VSVYAVPDK 21.50% AGLQFPVGR VTIAQGGVLPNIQAVLLPK 34.70% AAEESASQIQSSAQR AGGAFLMAGQVAEQLR AHAVEGQVEDVVGNLR AVLSSPAVTEQEVAQVASAILSLR
CDCNILGSR EGFGGLMCSAAAIR GFNAQLQR GYHPPSAYYAVSQLR IQEVGEITNLR ISSADPSGAFR LEMSSLPDLTPTFNK LETQVSASR LGQSSMLGEQGAR LLIQQVR LPNVDLVLSQTK LQAEAEEAR MLSTAYEQSAQAAQQVSDSSR MNEIQAIAAR QGTVALQEAQDTMQGTSR QLGDFWTR QQGAEAVQAQQLAEGASEQALSAQEGFER
Malate dehydrogenase, cytoplasmic MDHC_HUMAN MDH1
36,409
100.00%
12
12
102
RLQAEAEEAR RVEQIR SADLTGLEK SFNGLLTMYQR TEAEELFGETMEMMDR TLQGLQLDLPLEEETLSLPR TYGDVATGCR VAEVQQVLRPAEK VENVASSSGPMR VQLNLMDLVSGIPATQSQK 43.10% AICDHVR DVIATDKEDVAFK ELTEEKESAFEFLSSA ENFSCLTR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
45.9 39.9 31.7 40.1 77.1 36.0 48.9 34.0 34.6 47.1 26.9 67.6 33.7 40.5 65.0 62.7 107.0 96.2 95.2 107.0 34.8 85.4 54.6 46.4 71.4 62.7 79.7 82.1 85.5 46.4 80.8 39.6 139.0 91.6 102.0 45.7 87.6 48.5 33.5 40.0 48.3 91.0 85.7 47.0 60.8 65.9 123.0 33.1 93.9 75.1 47.2
20.0 15.6 20.3 19.5 22.3 21.9 19.9 21.0 18.7 20.3 17.7 19.0 22.0 21.6 22.4 11.1 22.4 22.3 21.4 16.6 17.4 21.3 23.9 22.7 22.5 23.5 21.6 23.5 22.9 13.8 19.5 21.0 20.2 23.2 21.5 22.9 20.3 22.7 22.6 24.0 23.0 11.1 16.5 18.1 18.2 22.2 19.7 20.8 23.0 21.6 20.0
0 4 2 2 8 2 1 1 2 3 0 8 1 2 5 14 36 18 5 4 1 2 5 0 17 4 11 18 21 2 28 2 6 15 6 4 0 3 1 4 4 9 12 1 5 38 15 1 11 28 2
1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 2 0 18 5 0 0 0 3 0 0 0 0 0 0 0 0 4 0 6 0 5 0 0 0 0 0 1 0 1 0 3 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
2,433.12 1,116.68 1,144.53 1,238.69 1,404.75 1,560.83 1,394.62 1,148.54 1,035.58 1,683.92 1,913.06 1,515.85 932.45 977.53 944.53 1,931.17 1,562.74 1,634.83 1,692.87 2,439.35 1,094.47 1,455.67 933.49 1,708.84 1,271.70 1,107.54 1,692.85 990.52 1,333.65 869.56 1,326.76 1,016.50 2,274.03 1,116.58 1,936.90 1,022.51 3,031.44 1,172.60 800.47 933.49 1,329.66 1,950.78 2,265.23 1,099.48 1,466.83 1,249.58 2,058.09 870.43 1,450.74 1,816.85 1,026.47
Table S1 page 141/159
Annexin A5
ANXA5_HUMAN ANXA5
35,921
100.00%
25
34
482
EVGVYEALKDDSWLK FVEGLPINDFSR GEFVTTVQQR LGVTANDVK LSSAMSAAK NVIIWGNHSSTQYPDVNHAK SQGAALDK VIVVGNPANTNCLTASK 75.90% ADAETLR ADAETLRK DLLDDLKSELTGK DPDAGIDEAQVEQDAQALFQAGELK
ETSGNLEQLLLAVVK FITIFGTR GAGTDDHTLIR GLGTDEESILTLLTSR GTVTDFPGFDER GTVTDFPGFDERADAETLR KNFATSLYSMIK LIVALMKPSR LYDAYELK MLVVLLQANR NFATSLYSMIK QEISAAFK QVYEEEYGSSLEDDVVGDTSGYYQR
GDP-L-fucose synthase
FCL_HUMAN TSTA3
35,875
99.50%
2
2
10
9.35%
Ran-specific GTPase-activating protein
RANG_HUMAN RANBP1
23,293
100.00%
3
3
9
16.40%
Ephrin type-A receptor 2
EPHA2_HUMAN EPHA2
108,249
100.00%
4
4
8
4.30%
162,232
99.50%
2
2
2
1.95%
35,062
99.50%
2
2
4
9.77%
27,530
100.00%
8
8
19
49.20%
CAP-Gly domain-containing linker CLIP1_HUMAN CLIP1 protein 1 Serine/threonine-protein phosphatase PP4C_HUMAN PPP4C 4 catalytic subunit 6PGL_HUMAN PGLS 6-phosphogluconolactonase
SEIDLFNIR SEIDLFNIRK SIPAYLAETLYYAMK TPEELR VLTEIIASR WGTDEEK WGTDEEKFITIFGTR YMTISGFQIEETIDR DADLTDTAQTR VVADGAGLPGEDWVFVSSK FASENDLPEWK TLEEDEEELFK VAEKLEALSVK FADIVSILDK LNVEER VLEDDPEATYTTSGGK YSEPPHGLTR LTNLQENLSEVSQVK SQQLSALQEENVK EILVEESNVQR VGGDVPETNYLFMGDFVDR ELPAAVAPAGPASLAR ILEDQEENPLPAALVQPHTGK IVAPISDSPKPPPQR LCWFLDEAAAR LPIPESQVITINPELPVEEAAEDYAK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
74.4 63.8 76.5 61.6 39.1 50.0 34.8 133.0 42.8 48.4 86.8 89.2 110.0 54.0 84.3 126.0 64.6 45.4 56.8 65.3 53.3 38.8 69.9 47.2 36.5 68.2 38.8 80.6 40.6 78.8 30.9 78.2 56.9 78.7 32.2 57.4 49.3 29.3 50.8 34.7 52.7 27.0 47.7 51.8 37.7 70.8 43.7 62.6 59.0 56.5 28.7
21.1 22.9 23.3 23.0 21.6 22.0 24.9 21.5 24.0 23.2 22.9 20.5 19.2 19.7 22.0 22.1 21.2 21.9 22.7 15.6 21.1 20.1 22.0 22.0 17.2 23.7 21.3 22.7 20.7 19.8 17.6 22.1 22.0 20.7 22.0 21.4 21.3 17.4 21.7 23.4 20.9 22.0 21.5 21.8 22.9 20.9 19.6 20.6 18.2 22.3 19.7
8 12 12 15 1 0 1 4 2 6 24 2 29 10 20 30 44 0 5 5 13 2 62 13 1 64 3 25 1 38 1 19 3 9 1 2 6 0 4 2 1 0 1 1 2 2 3 0 2 1 0
0 0 0 0 0 7 0 0 0 0 1 4 1 0 1 5 0 3 1 13 0 0 0 0 0 0 0 3 0 0 0 28 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 2 0 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,751.89 1,393.71 1,164.60 916.51 881.44 2,280.12 789.41 1,757.92 775.40 903.49 1,446.77 2,658.25 1,613.91 954.54 1,155.58 1,704.90 1,340.61 2,096.99 1,402.74 1,127.70 1,014.51 1,172.68 1,290.64 893.47 2,888.24 1,106.58 1,234.68 1,749.88 744.39 1,001.60 864.37 1,799.90 1,818.86 1,206.56 1,932.97 1,335.62 1,381.64 1,186.70 1,120.63 759.40 1,682.78 1,156.58 1,701.90 1,473.76 1,315.69 2,130.98 1,490.83 2,299.19 1,601.90 1,351.65 2,865.48
Table S1 page 142/159
Small nuclear ribonucleoprotein Sm SMD3_HUMAN SNRPD3 D3 HNRH1_HUMAN HNRNPH1 Heterogeneous nuclear ribonucleoprotein H
13,899
99.50%
2
2
4
15.10%
49,212
100.00%
6
9
90
18.70%
SERA_HUMAN PHGDH
56,633
99.50%
2
2
2
3.19%
GLOD4_HUMAN GLOD4
34,776
100.00%
6
7
20
22.00%
Isoleucyl-tRNA synthetase, cytoplasmic
SYIC_HUMAN IARS
144,484
100.00%
3
3
4
2.06%
Myosin-Ic
MYO1C_HUMAN MYO1C
121,709
100.00%
2
2
2
3.29%
Interleukin-18
IL18_HUMAN IL18
22,309
100.00%
2
2
6
8.81%
Calsyntenin-1
CSTN1_HUMAN CLSTN1
109,774
100.00%
30
36
929
28.70%
D-3-phosphoglycerate dehydrogenase Glyoxalase domain-containing protein 4
LVPFDHAESTYGLYR TVIFVATGEGK VTLTLPVLNAAR FLILPDMLK VAQLEQVYIR ATENDIYNFFSPLNPVR GLPWSCSADEVQR HTGPNSPDTANDGFVR SNNVEMDWVLK STGEAFVQFASQEIAEK VHIEIGPDGR DLPLLLFR TLGILGLGR ELPDLEDLMK GGVDHAAAFGR ILTPLVSLDTPGK IYEKDEEK LLDDAMAADKSDEWFAK VTLAVSDLQK FLIQNVLR LESDYEILER LLILMEAR GEELLSPLNLEQAAYAR VLQALGSEPIQYAVPVVK SDIIFFQR TIFIISMYK AASEFESSEGVFLFPELR AMQHISYLNSR ATEDVLVK ATVHIQVNDVNEYAPVFK ATVIEGK EGLDLQVLEDSGR EKLDCELQK EPFTISVWMR ETILCSSDK ETILCSSDKTDMNR GNLAGLTLR GPDGTNVK GPDGTNVKK GVQIQAHPSQLVLTLEGEDLGELDK
IHGQNVPFDAVVVDK IISTITR IPDGVVSVSPK IPDGVVSVSPKEPFTISVWMR ISIKPTCTPGWQGWNNR ISLSGVHHFAR LDCELQK LIFLFR LTVTAYDCGK QFPTPGIR QYDSILR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
35.5 47.7 68.2 31.4 75.2 74.0 34.1 97.0 40.3 104.0 44.3 41.0 30.7 46.2 55.9 60.9 31.1 33.1 53.3 33.8 34.5 41.6 34.5 47.5 51.8 37.1 85.6 75.3 65.0 78.9 44.9 108.0 32.4 42.3 36.5 65.2 67.2 61.1 36.8 64.9 101.0 55.9 74.8 46.4 42.5 78.3 37.1 44.1 49.2 44.6 51.9
22.5 22.0 12.6 19.8 22.7 22.4 20.8 20.9 21.6 22.0 22.2 19.3 18.9 21.8 21.5 15.6 22.7 20.4 21.0 16.9 22.8 20.4 22.0 15.6 21.9 22.6 22.3 23.0 23.6 21.9 25.5 22.2 23.9 22.2 21.2 19.8 20.8 20.0 21.6 19.8 21.5 17.9 19.4 21.3 22.2 21.0 22.4 12.8 22.3 23.1 22.4
2 2 6 3 1 23 1 12 1 36 3 1 1 2 4 8 1 0 3 2 1 1 1 1 3 3 188 21 20 25 16 124 1 16 1 2 80 4 3 0 35 44 98 0 1 6 6 17 8 7 17
0 0 0 0 0 1 0 12 0 0 1 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 2 14 0 50 0 0 0 0 0 0 0 0 0 20 28 0 0 2 11 16 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,767.87 1,121.62 1,267.77 1,089.64 1,218.68 1,996.98 1,504.69 1,684.77 1,350.64 1,841.89 1,092.58 986.60 899.57 1,202.60 1,057.52 1,353.80 1,053.51 1,941.89 1,073.62 1,002.61 1,266.62 974.57 1,873.97 1,911.10 1,025.54 1,131.61 2,014.98 1,319.65 874.49 2,044.05 717.41 1,430.71 1,162.58 1,281.63 1,052.49 1,685.75 914.54 787.40 915.49 2,689.41 1,637.87 803.50 1,097.62 2,360.23 2,014.99 1,223.66 905.44 808.51 1,127.54 915.51 894.47
Table S1 page 143/159
SLLDRK STGEGVIR VIDCLYTCK YISNEFK YRPAEFHWK TEESPASDEAGEKEAK VSSAEGAAKEEPK EQFVEFR TFDQLTPEESK WIYEDVER AAGDVDIGDAAYYFER DIKGESLFQGR TLIYYLDEIPPK GAMGPAGPDGHQGPR GEQGLTGMPGIR LLSTDASHSR LQGMAPAAGADLDK SELISYLTSPDVR DRPFFAGLVK FMQASEDLLK GDFCIQVGR GLVGEIIK GLVGEIIKR NIIHGSDSVESAEK TFIAIKPDGVQR VMLGETNPADSKPGTIR YMHSGPVVAMVWEGLNVVK AAHSEGNTTAGLDMR DASLMVTNDGATILK EAVAMESYAK GATQQILDEAER IGVNQPK ILIANTGMDTDKIK LGGSLADSYLDEGFLLDK LGGSLADSYLDEGFLLDKK LKGSGNLEAIHIIK SLHDALCVLAQTVK
Non-histone chromosomal protein HMG-14 Calumenin
HMGN1_HUMAN HMGN1
10,641
99.50%
2
2
4
29.00%
CALU_HUMAN CALU
37,090
100.00%
3
3
5
8.25%
Tumor-associated calcium signal transducer 2
TACD2_HUMAN TACSTD2
35,692
100.00%
3
3
13
12.10%
Collagen alpha-1(XVII) chain
COHA1_HUMAN COL17A1
150,404
100.00%
5
7
22
4.28%
Nucleoside diphosphate kinase A
NDKA_HUMAN NME1
17,131
100.00%
4
6
9
65.80%
T-complex protein 1 subunit beta
TCPB_HUMAN CCT2
57,472
100.00%
11
12
21
26.50%
Peptidyl-prolyl cis-trans isomerase H PPIH_HUMAN PPIH
19,190
100.00%
3
4
10
Ubiquitin-conjugating enzyme E2 L3 UB2L3_HUMAN UBE2L3
17,844
99.50%
2
3
8
Polypyrimidine tract-binding protein PTBP1_HUMAN PTBP1 1
57,205
100.00%
7
8
24
13.00% IENVPTGPNNKPK IIDGLLVMR KIENVPTGPNNKPK 24.00% IEINFPAEYPFKPPK TDQVIQSLIALVNDPQPEHPLR 20.00% DYGNSPLHR HQNVQLPR IAIPGLAGAGNSVLLVSNLNPER
VQDDEVGDGTTSVTVLAAELLR
NFQNIFPPSATLHLSNIPPSVSEEDLK
Nicotinamide
NAMPT_HUMAN NAMPT
55,505
100.00%
3
3
9
NNQFQALLQYADPVSAQHAK VLFSSNGGVVK VTNLLMLK 8.55% AVPEGFVIPR
95.0% 95.0% 95.0% 95.0% 94.6% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
32.3 53.5 64.3 35.7 26.2 26.5 70.8 33.2 33.0 33.1 99.6 30.1 39.4 73.6 41.9 55.3 60.0 44.1 47.4 61.9 51.1 36.3 52.3 73.1 34.9 88.7 45.3 40.3 43.9 44.8 86.1 32.4 44.7 85.8 38.9 18.6 31.2 141.0 29.8 55.0 63.0 32.4 92.6 31.7 43.5 144.0 29.3 51.2 48.2 47.7 33.9
23.2 24.3 21.1 20.2 23.6 19.9 22.5 21.2 22.4 21.6 20.0 23.3 20.6 20.2 23.3 21.8 22.3 22.6 20.3 22.9 22.8 16.7 16.7 21.9 19.8 22.3 21.4 18.6 22.2 20.5 22.1 20.0 21.6 22.6 22.0 14.3 20.8 21.9 21.1 19.9 19.5 21.4 19.2 21.7 21.4 14.0 20.6 21.6 21.1 19.5 19.5
3 16 24 2 0 0 3 1 2 2 9 2 2 2 2 5 4 2 2 2 4 2 5 2 2 4 0 0 1 4 2 1 1 2 0 0 1 2 0 4 2 0 2 2 2 7 0 0 2 2 1
0 0 0 0 1 1 0 0 0 0 0 0 0 3 0 4 0 0 1 0 0 0 0 1 0 8 1 2 0 0 0 0 0 0 2 0 0 2 2 0 2 1 5 0 0 2 1 6 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
731.44 818.44 1,171.55 900.45 1,233.62 1,677.75 1,302.65 954.47 1,294.62 1,109.53 1,732.78 1,249.65 1,464.80 1,420.64 1,231.61 1,086.55 1,373.67 1,479.77 1,149.64 1,181.59 1,051.50 828.52 984.62 1,485.72 1,344.76 1,785.92 2,116.07 1,546.69 1,564.79 1,114.51 1,330.66 755.44 1,548.83 1,912.95 2,041.05 1,492.89 1,554.83 2,288.16 1,407.76 1,029.61 1,535.85 1,789.95 2,483.33 1,058.50 991.54 2,275.28 2,994.52 2,243.12 1,106.62 931.57 1,084.62
Table S1 page 144/159
phosphoribosyltransferase Probable aminopeptidase NPEPL1
PEPL1_HUMAN NPEPL1
55,843
99.50%
2
2
6
Glucose-6-phosphate 1dehydrogenase
G6PD_HUMAN G6PD
59,240
100.00%
18
22
114
Eukaryotic translation initiation factor 2 subunit 1
IF2A_HUMAN EIF2S1
36,095
100.00%
7
7
15
Proteasome subunit alpha type-7
PSA7_HUMAN PSMA7
27,869
100.00%
12
15
93
GTDTVAGLALIK VIQGDGVDINTLQEIVEGMK 5.16% ELGIIPTIIRDEELK TVEINNTDAEGR 41.20% CISEVQANNVVLGQYVGNPDGEGEATK DGLLPENTFIVGYAR EMVQNLMVLR GGYFDEFGIIR GPTEADELMK GPTEADELMKR GYLDDPTVPR IFGPIWNR IIVEKPFGR KPGMFFNPEESELDLTYGNR LFYLALPPTVYEAVTK LKLEDFFAR LNSHMNALHLGSQANR LPDAYER LSNHISSLFR NSYVAGQYDDAASYQR QSEPFFK VGFQYEGTYK 23.80% AGLNCSTENMPIK GVFNVQMEPK INLIAPPR LTPQAVK TEGLSVLSQAMAVIK VVTDTDETELAR YVMTTTTLER 45.60% AITVFSPDGHLFQVEYAQEAVK AITVFSPDGHLFQVEYAQEAVKK
Semaphorin-7A
SEM7A_HUMAN SEMA7A
74,806
100.00%
5
5
21
Density-regulated protein
DENR_HUMAN DENR
22,074
100.00%
4
4
11
ADP-ribose pyrophosphatase,
NUDT9_HUMAN NUDT9
39,108
99.50%
2
2
2
ALLEVVQSGGK DIVVLGVEK GRDIVVLGVEK GSTAVGVR ILNPEEIEK KGSTAVGVR LTVEDPVTVEYITR LYQTDPSGTYHAWK NIELAVMR NYTDEAIETDDLTIK 8.86% AAAIQTMSLDAER GDQGGESSLSVSK LQDVFLLPDPSGQWR VSLAPNSR VYLFDFPEGK 21.70% LDADYPLR QEAGISEGQGTAGEEEEK WPEVDDDSIEDLGEVK WPEVDDDSIEDLGEVKK 7.43% EFGEEALNSLQK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
59.0 126.0 34.5 59.6 70.8 79.2 64.1 54.9 40.2 51.0 45.3 41.0 34.0 43.0 48.6 43.6 61.4 45.2 33.4 98.6 33.2 37.1 42.6 38.4 45.0 33.3 37.7 78.6 30.2 56.5 35.1 81.3 45.2 63.9 37.6 34.7 43.8 102.0 70.9 40.2 136.0 61.3 66.7 51.4 32.3 55.8 46.0 82.1 95.8 42.7 40.9
21.6 20.7 15.6 21.7 20.9 22.8 22.9 21.8 21.9 22.9 23.1 24.8 18.6 19.3 17.6 20.3 22.6 24.0 23.7 19.3 21.5 22.9 19.7 23.2 13.0 15.4 20.3 23.8 22.2 21.7 20.7 22.7 19.8 19.2 24.2 20.8 21.7 22.1 21.8 24.5 21.2 22.1 22.9 22.5 22.6 22.2 23.6 18.8 20.5 21.5 22.7
2 6 1 5 0 11 8 9 3 4 5 6 2 0 7 7 1 5 1 19 2 3 2 2 2 1 1 6 1 2 0 12 2 6 1 3 1 17 4 4 31 3 6 4 3 5 4 3 2 0 1
0 0 0 0 2 0 0 0 0 0 0 0 0 4 0 10 1 0 2 0 0 0 0 0 0 0 0 0 0 5 2 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 0 2 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,158.67 2,158.11 1,739.00 1,318.62 2,848.34 1,664.87 1,232.65 1,273.62 1,106.50 1,262.61 1,132.56 1,002.55 1,058.64 2,360.09 1,825.02 1,138.63 1,778.87 863.43 1,173.64 1,807.79 882.44 1,191.57 1,450.67 1,164.57 893.56 756.46 1,546.85 1,348.66 1,214.61 2,449.24 2,577.34 1,100.63 971.58 1,184.70 746.42 1,084.59 874.51 1,634.86 1,666.79 945.52 1,740.82 1,392.68 1,250.59 1,770.92 843.47 1,214.61 962.49 1,848.81 1,845.84 1,973.93 1,364.67
Table S1 page 145/159
mitochondrial Glycogen debranching enzyme
GDE_HUMAN AGL
174,750
100.00%
11
11
19
High mobility group protein B2
HMGB2_HUMAN HMGB2
24,017
100.00%
8
11
42
Phosphatidylethanolamine-binding protein 1
PEBP1_HUMAN PEBP1
21,039
100.00%
8
9
55
WADPQISESNFSPK 8.88% AVTVYTNYPFPGETFNR FPSLPILSPALMDVPYR IPFASLASR LEQGYELQFR LGISSLIR LGPTLQGK LTLAELNQILYR SDPNQHLTIIQDPEYR SGGGYIVVDPILR SGSLAVDNADPILK YTWNDVGQLVEK 33.00% HPDSSVNFAEFSK IKSEHPGLSIGDTAK KLGEMWSEQSAK LGEMWSEQSAK MSSYAFFVQTCR SEHPGLSIGDTAK SKFEDMAK YEKDIAAYR 59.40% GNDISSGTVLSDYVGSGPPK LYEQLSGK LYTLVLTDPDAPSR LYTLVLTDPDAPSRK NRPTSISWDGLDSGK VLTPTQVK WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK
Protein FAM49B
FA49B_HUMAN FAM49B
Uncharacterized glycosyltransferase AER61_HUMAN AER61 AER61
36,731
100.00%
11
13
37
61,994
100.00%
3
3
5
32,931
100.00%
3
3
10
F-actin-capping protein subunit alpha-2
CAZA2_HUMAN CAPZA2
60S ribosomal protein L7
RL7_HUMAN
RPL7
29,210
100.00%
2
2
4
Leucyl-tRNA synthetase, cytoplasmic
SYLC_HUMAN LARS
134,453
99.50%
2
2
3
YVWLVYEQDRPLK 42.00% AWGAVVPLVGK DAEGILEDLQSYR DQPPNSVEGLLNALR EAIQHPADEK EAIQHPADEKLQEK GLLGALTSTPYSPTQHLER HLNDETTSK INNVPAEGENEVNNELANR MSLFYAEATPMLK MTNPAIQNDFSYYR VMLETPEYR 5.69% EAVFSLLPR ELGFLDQLR ILNQNELVNALK 27.60% EGAAHAFAQYNLDQFTPVK FIIHAPPGEFNEVFNDVR FTITPSTTQVVGILK IQVHYYEDGNVQLVSHK LLLNNDNLLR 10.10% IALTDNALIAR IVEPYIAWGYPNLK 1.96% FDDPLLGPR STGNFLTLTQAIDK
95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
48.9 68.9 44.0 31.6 30.2 43.2 30.9 49.8 26.4 64.2 64.4 59.1 36.0 62.0 47.2 65.6 104.0 47.2 32.1 50.4 121.0 58.7 97.2 64.7 79.3 30.4 26.1 38.1 48.5 84.7 81.7 39.8 74.0 59.2 45.4 94.3 65.6 99.5 40.3 65.3 44.9 45.6 36.8 36.6 78.8 40.7 72.5 70.4 55.3 35.2 61.7
22.0 21.2 19.8 21.2 21.9 20.1 17.9 17.5 21.6 20.8 21.5 22.4 21.1 21.0 22.2 20.6 19.7 22.5 20.0 22.0 22.7 20.9 22.5 20.2 22.9 17.2 19.2 21.3 17.6 22.3 21.5 23.2 22.8 21.3 19.7 21.6 22.7 21.5 23.0 20.8 23.2 17.6 22.3 21.8 14.1 22.2 19.2 20.1 20.3 22.0 21.7
1 2 1 1 1 2 1 2 0 3 3 2 1 2 2 2 19 5 1 5 14 12 13 0 6 1 0 1 3 4 6 1 2 2 1 2 5 4 3 2 2 1 0 0 6 0 14 2 2 1 2
0 0 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 1 0 2 0 0 0 3 3 0 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 2 2 0 11 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,605.76 1,975.96 1,932.03 961.55 1,282.64 858.54 813.48 1,446.83 1,925.94 1,345.75 1,399.74 1,451.72 1,464.68 1,552.83 1,409.67 1,265.58 1,512.66 1,311.65 955.46 1,128.57 1,949.95 937.50 1,560.83 1,688.92 1,632.80 885.54 3,471.72 1,708.91 1,096.65 1,508.72 1,622.85 1,137.55 1,635.83 2,041.07 1,044.50 2,096.00 1,533.73 1,735.78 1,137.56 1,031.59 1,090.59 1,368.79 2,107.03 2,101.05 1,604.93 2,029.01 1,197.70 1,170.68 1,662.89 1,029.54 1,508.80
Table S1 page 146/159
Semaphorin-5A
SEM5A_HUMAN SEMA5A
120,597
100.00%
2
2
4
Metalloproteinase inhibitor 2
TIMP2_HUMAN TIMP2
24,382
100.00%
7
9
36
Glyceraldehyde-3-phosphate dehydrogenase
G3P_HUMAN
36,035
100.00%
14
19
204
GAPDH
2.42% LADPNLLEVGR NAVDFSQLTFDPGQK 25.90% AVSEKEVDSGNDIYGNPIK EVDSGNDIYGNPIK EVDSGNDIYGNPIKR EYLIAGK GAAPPKQEFLDIEDP IQYEIK SDGSCAWYR 51.90% AGAHLQGGAK GALQNIIPASTGAAK IISNASCTTNCLAPLAK LISWYDNEFGYSNR LTGMAFR LVINGNPITIFQER LVINGNPITIFQERDPSK RVIISAPSADAPMFVMGVNHEK VIHDNFGIVEGLMTTVHAITATQK
T-complex protein 1 subunit eta
TCPH_HUMAN CCT7
59,350
100.00%
14
15
37
VIISAPSADAPMFVMGVNHEK VPTANVSVVDLTCR VVDLMAHMASK VVDLMAHMASKE WGDAGAEYVVESTGVFTTMEK 37.00% ALEIIPR EGTDSSQGIPQLVSNISACQVIAEAVR
Eukaryotic translation initiation factor 3 subunit D
EIF3D_HUMAN EIF3D
63,956
100.00%
3
4
8
Ras GTPase-activating proteinbinding protein 2 GMP synthase [glutaminehydrolyzing]
G3BP2_HUMAN G3BP2
54,102
99.50%
2
2
3
GUAA_HUMAN GMPS
76,699
100.00%
4
4
7
Rho GDP-dissociation inhibitor 1
GDIR1_HUMAN ARHGDIA
23,190
100.00%
3
5
28
Uridine diphosphate glucose pyrophosphatase
NUD14_HUMAN NUDT14
24,100
100.00%
4
4
6
GGAEQFMEETER LLDVVHPAAK LPIGDVATQYFADR MVVDAVMMLDDLLQLK QLCDNAGFDATNILNK QVKPYVEEGLHPQIIIR SLHDAIMIVR SQDAEVGDGTTSVTLLAAEFLK STVDAPTAAGR TATQLAVNK TFSYAGFEMQPK VQGGALEDSQLVAGVAFK 8.94% IFHTVTTTDDPVIR LGDDIDLIVR YNFPNPNPFVEDDMDKNEIASVAYR
6.22% LPNFGFVVFDDSEPVQR VEAKPEVQSQPPR 7.94% ELGLPEELVSR EPPTDVTPTFLTTGVLSTLR SGNIVAGIANESK TLNMTTSPEEK 22.10% AEEYEFLTPVEEAPK IDKTDYMVGSYGPR SIQEIQELDKDDESLR 21.60% IEGASVGR QFRPAVYAGEVER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
54.9 69.2 103.0 80.1 91.5 34.0 48.1 40.9 35.0 69.1 95.3 93.8 97.8 46.0 86.9 62.0 47.1 45.6 90.5 119.0 47.8 61.5 133.0 43.5 32.8 63.8 39.3 96.5 73.3 57.9 18.5 30.0 135.0 56.2 44.0 68.7 51.0 57.5 75.9 45.1 33.3 33.4 43.2 88.5 46.8 37.2 82.3 83.1 90.4 34.7 31.5
19.9 22.4 22.8 22.6 22.2 21.8 22.6 21.8 15.4 21.2 20.5 22.3 21.3 22.0 20.6 18.6 21.7 20.2 21.7 22.9 22.7 22.5 20.1 15.4 20.6 16.7 17.0 22.8 21.5 23.1 14.3 21.3 22.4 21.6 22.8 19.4 21.5 21.9 21.7 19.0 22.2 21.3 20.9 19.6 23.2 22.6 22.6 22.3 22.2 24.3 22.3
2 2 2 3 10 5 7 4 1 15 25 4 6 8 22 2 0 0 6 20 2 18 21 2 0 6 2 2 4 2 0 1 5 5 2 2 1 2 2 0 1 0 1 2 1 3 19 2 2 1 0
0 0 2 0 2 0 0 0 0 0 0 0 0 0 0 1 4 13 2 2 0 0 12 0 1 0 0 0 0 0 0 0 1 0 0 0 0 2 0 2 0 2 0 0 0 0 0 4 1 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,196.66 1,666.81 2,035.00 1,520.72 1,676.82 793.45 1,626.80 793.45 1,101.44 909.49 1,411.79 1,833.92 1,763.80 811.41 1,613.90 2,041.11 2,401.20 2,611.36 2,213.11 1,530.80 1,201.61 1,330.65 2,293.03 811.50 2,829.41 1,399.58 1,062.63 1,565.80 1,881.94 1,793.85 2,019.14 1,170.63 2,252.13 1,045.53 945.54 1,421.64 1,788.95 1,614.85 1,128.63 2,961.34 1,965.97 1,464.78 1,241.67 2,145.14 1,259.66 1,266.59 1,751.84 1,601.76 1,917.94 788.43 1,521.78
Table S1 page 147/159
Malignant T cell-amplified sequence MCTS1_HUMAN MCTS1 1
Interleukin-1 receptor antagonist protein Serpin B3
20,538
100.00%
4
6
7
31.50%
IL1RA_HUMAN IL1RN
20,037
99.90%
2
2
4
19.20%
SPB3_HUMAN SERPINB3
44,548
100.00%
8
9
22
25.10%
37,496
100.00%
6
6
11
19.70%
106,795
100.00%
9
9
15
13.10%
41,463
100.00%
2
2
3
7.25%
99,349
99.50%
2
2
3
3.41%
72,355
100.00%
3
3
7
6.00%
38,850
100.00%
4
4
18
19.80%
Serine/threonine-protein phosphatase PP1A_HUMAN PPP1CA PP1-alpha catalytic subunit
Alanyl-tRNA synthetase, cytoplasmic
SYAC_HUMAN AARS
ADH7_HUMAN ADH7 Alcohol dehydrogenase class 4 mu/sigma chain Pyruvate dehydrogenase phosphatase PDPR_HUMAN PDPR regulatory subunit, mitochondrial DDX17_HUMAN DDX17 Probable ATP-dependent RNA helicase DDX17
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
NHRF1_HUMAN SLC9A3R1
Phosphoglucomutase-1
PGM1_HUMAN PGM1
61,433
100.00%
22
27
112
QTMFYTEVTDAQR VATYWSGVGLTGSR LYPAAVDTIVAIMAEGK MSAEDIEK NQLIEQFPGIEPWLNQIMPK YPFILPHQQVDK LQLEAVNITDLSENR NNQLVAGYLQGPNVNLEEK DLSMIVLLPNEIDGLQK DNTAQQIK FYQTSVESVDFANAPEESR GLVLSGVLHK INSWVESQTNEK LMEWTSLQNMR VDLHLPR VLHFDQVTENTTGK EIFLSQPILLELEAPLK IKYPENFFLLR LNLDSIIGR NVQLTENEIR TFTDCFNCLPIAAIVDEK YPENFFLLR ASEWVQQVSGLMDGK AVFDETYPDPVR EIADLGEALATAVIPQWQK GLEVTDDSPK IVAVTGAEAQK MALELLTQEFGIPIER MSNYDTDLFVPYFEAIQK QIWQNLGLDDTK VGAEDADGIDMAYR ISEGFELLNSGQSIR MLTYDPMLLFTGR INAGLNVIGIPSEIISPK TGSIFLAQTQDR APILIATDVASR ELAQQVQQVADDYGK VLEEANQAINPK AQEAPGQAEPPAAAEVQGAGNENEPR
EALAEAALESPRPALVR LLVVDPETDEQLQK SVDPDSPAEASGLR 46.60% ADNFEYSDPVDGSISR DLEALMFDR EAIQLIAR FFGNLMDASK FNISNGGPAPEAITDK IAAANGIGR IALYETPTGWK IDAMHGVVGPYVK INQDPQVMLAPLISIALK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
54.0 79.5 82.7 32.0 50.0 34.0 67.1 109.0 57.2 53.8 93.2 48.7 73.8 54.2 49.4 68.3 56.9 31.7 47.5 39.4 74.1 55.5 41.4 47.0 53.0 38.0 40.7 37.4 42.6 31.2 72.0 87.8 53.2 36.1 51.3 57.3 53.1 52.7 75.9 35.6 68.0 51.7 108.0 48.1 45.7 60.0 104.0 47.2 31.5 46.1 97.5
19.2 22.2 20.9 20.3 20.3 21.1 22.2 21.6 19.3 23.3 19.8 12.3 21.6 22.4 20.0 22.9 13.6 18.6 20.9 23.7 21.4 21.1 22.6 22.0 18.8 23.0 21.2 21.2 20.3 22.4 19.2 22.6 22.6 12.8 22.8 18.5 22.9 21.3 21.0 19.1 21.1 21.7 18.2 21.8 19.3 20.5 22.5 20.0 22.7 22.5 16.3
2 2 2 1 1 1 2 2 4 1 2 2 2 5 3 2 3 0 2 1 2 2 1 2 2 2 2 2 1 1 2 2 1 1 2 5 1 1 0 0 9 6 5 7 2 4 2 2 1 2 20
0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 2 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,605.72 1,453.74 1,761.95 938.41 2,411.24 1,484.79 1,714.90 2,100.07 1,898.03 917.47 2,175.98 1,022.64 1,434.69 1,408.67 849.49 1,588.80 1,953.13 1,439.81 1,000.58 1,215.63 2,113.99 1,198.63 1,634.79 1,408.68 2,053.10 1,060.52 1,086.62 1,875.99 2,197.02 1,430.73 1,498.65 1,649.85 1,573.78 1,835.06 1,336.69 1,226.71 1,691.82 1,325.71 2,588.20 1,792.99 1,626.86 1,400.67 1,771.78 1,109.53 913.55 1,129.54 1,630.81 842.48 1,278.67 1,385.73 1,980.12
Table S1 page 148/159
LSGTGSAGATIR LVIGQNGILSTPAVSCIIR LYIDSYEKDVAK QEATLVVGGDGR QFSANDK QFSANDKVYTVEK SGEHDFGAAFDGDGDRNMILGK
Kallikrein-11
KLK11_HUMAN KLK11
31,041
100.00%
2
2
18
7.45%
Basic leucine zipper and W2 domain-containing protein 2 26S protease regulatory subunit 6A
BZW2_HUMAN BZW2
48,146
99.50%
2
2
6
6.68%
PRS6A_HUMAN PSMC3
49,187
100.00%
4
4
5
13.70%
Cadherin-1
CADH1_HUMAN CDH1
97,440
100.00%
14
16
158
18.40%
Cystatin-B
CYTB_HUMAN CSTB
11,121
100.00%
3
3
12
45.90%
Splicing factor, proline- and glutamine-rich
SFPQ_HUMAN SFPQ
76,132
100.00%
4
4
6
6.65%
Beta-hexosaminidase subunit alpha
HEXA_HUMAN HEXA
60,672
100.00%
11
12
70
25.10%
SIFDFSALK SMPTSGALDR TQAYQDQKPGTSGLR VDLGVLGK VSQLQER YDYEEVEAEGANK LLCGATLIAPR YVDWIQETMK DTLVQGLNEAGDDLEAVAK LLELFPVNR LAGPQLVQMFIGDGAK QTYFLPVIGLVDAEK TMLELLNQLDGFQPNTQVK VDILDPALLR DTANWLEINPDTGAISTR FKVGTDGVITVK GLDFEAK GQVPENEANVVITTLK MALEVGDYK NDVAPTLMSVPR NMFTINR NTGVISVVTTGLDR TAYFSLDTR VFYSITGQGADTPPVGVFIIER VGTDGVITVK VNFEDCTGR VTEPLDR YLPRPANPDEIGNFIDENLK SQVVAGTNYFIK VFQSLPHENKPLTLSNYQTNK VHVGDEDFVHLR FATHAAALSVR LFVGNLPADITEDEFK LFVGNLPADITEDEFKR MGGGGAMNMGDPYGSGGQK ALLSAPWYLNR DFYVVEPLAFEGTPEQK DLLFGSGSWPRPYLTGK EDIPVNYMK GLETFSQLVWK GSYNPVTHIYTAQDVK GYVVWQEVFDNK IQPDTIIQVWR LTSDLTFAYER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
81.2 47.1 73.0 84.8 41.8 28.0 33.2 39.5 31.6 69.5 50.7 55.2 112.0 85.1 52.6 123.0 53.4 34.6 60.1 64.5 32.9 120.0 52.7 41.4 97.7 64.9 34.7 30.6 121.0 71.1 115.0 80.0 60.1 34.0 30.2 53.9 81.3 63.5 42.2 66.3 28.8 30.3 57.9 72.9 36.6 30.5 50.5 69.2 54.2 50.4 83.6
23.2 15.8 22.5 22.5 22.1 22.5 18.8 20.7 21.4 23.0 20.0 23.4 16.8 20.6 20.8 21.7 20.4 21.7 19.1 21.4 13.8 22.2 17.4 23.6 20.3 21.1 22.3 21.9 20.8 21.2 20.2 21.7 17.8 21.0 21.4 21.1 20.6 22.6 23.3 22.7 22.0 10.0 22.2 21.8 21.7 22.0 21.0 22.5 22.1 19.0 22.1
23 2 2 8 2 0 0 1 1 3 4 2 6 9 9 3 3 1 2 1 1 41 2 2 31 9 2 2 10 4 14 5 3 4 0 4 2 0 0 2 0 1 12 19 1 1 7 4 2 8 4
0 0 1 0 0 1 2 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 26 0 2 0 0 0 0 0 0 0 0 0 1 0 0 6 2 0 1 0 0 0 0 0 0 1 0 0 0
0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,090.59 2,011.14 1,443.74 1,201.62 809.38 1,528.76 2,325.02 1,027.55 1,050.49 1,649.83 800.49 859.46 1,516.64 1,184.68 1,328.62 1,957.97 1,100.65 1,660.87 1,692.92 2,205.12 1,124.67 1,973.96 1,263.73 779.39 1,711.92 1,025.50 1,299.67 895.45 1,431.78 1,073.53 2,366.24 988.57 1,097.47 829.44 2,315.17 1,326.71 2,458.27 1,422.71 1,143.63 1,807.91 1,964.01 1,819.71 1,303.72 1,968.96 1,893.99 1,124.53 1,307.70 1,792.89 1,483.72 1,368.76 1,315.65
Table S1 page 149/159
NAD(P)H dehydrogenase [quinone] NQO1_HUMAN NQO1 1
30,851
100.00%
5
6
12
Splicing factor, arginine/serine-rich 4 SFRS4_HUMAN SFRS4
56,662
100.00%
3
3
8
Proliferation-associated protein 2G4 PA2G4_HUMAN PA2G4
43,769
100.00%
21
23
195
SNPEIQDFMR TEIEDFPR 21.20% ALIVLAHSER EAAAAALKK EGHLSPDIVAEQK IQILEGWK LKDPANFQYPAESVLAYK 11.90% GESENAGTNQETR LDGTEVNGR LIVENLSSR LVEDKPGSR QAGEVTYADAHK VIVEHAR 54.30% AAHLCAEAALR AFFSEVER ALLQSSASR EGEFVAQFK FDAMPFTLR FTVLLMPNGPMR GDAMIMEETGK HELLQPFNVLYEK ITSGPFEPDLYK ITSGPFEPDLYKSEMEVQDAELK
AMPL_HUMAN LAP3
56,150
100.00%
6
6
10
Phosphoribosylformylglycinamidine PUR4_HUMAN PFAS synthase
144,706
100.00%
8
8
14
8,547
100.00%
5
6
102
Cytosol aminopeptidase
Ubiquitin
UBIQ_HUMAN RPS27A
LVKPGNQNTQVTEAWNK MGGDIANR MGVVECAK RFDAMPFTLR SDQDYILK SEMEVQDAELK SLVEASSSGVSVLSLCEK TAENATSGETLEENEAGD TIIQNPTDQQK TIIQNPTDQQKK VAHSFNCTPIEGMLSHQLK 16.00% EKEDDVPQFTSAGENFDK GITFDSGGISIK GSPNANEPPLVFVGK GVLFASGQNLAR QLMETPANEMTPTR TIQVDNTDAEGR 6.35% ELSDPAGAIIYTSR EPGGPSPR FGEPVLAGFAR FQQQQGLR LNFSTPTSTNIVSVCR SLGLQLPDGQR VGPGPALMLR VGTETVR 69.70% ESTLHLVLR IQDKEGIPPDQQR QLEDGR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
52.0 37.6 63.9 33.0 67.4 43.9 54.7 54.6 53.3 52.6 59.5 51.6 44.6 45.9 57.6 61.4 47.2 51.3 59.7 63.8 72.8 76.7 49.8 63.5 67.6 30.8 31.1 62.0 78.2 86.1 104.0 51.4 53.7 28.6 32.7 40.7 48.0 46.7 59.7 62.5 77.4 32.1 62.2 33.8 68.5 51.1 32.2 40.9 46.9 73.5 31.8
19.6 22.1 18.3 21.8 22.7 23.1 21.2 18.0 22.7 21.6 22.0 21.4 18.7 22.1 21.1 22.0 21.9 21.5 22.7 19.7 21.5 22.5 21.6 21.0 21.4 21.8 21.6 22.0 20.6 22.3 16.0 22.0 21.1 21.5 19.2 22.0 22.4 23.0 20.9 21.7 23.0 20.2 23.0 23.9 22.0 20.8 18.8 25.0 18.4 21.4 20.8
8 3 2 1 3 2 1 1 3 11 4 3 4 0 12 16 9 8 6 19 6 7 0 6 7 1 1 11 10 14 10 17 4 0 0 1 2 2 2 2 2 1 3 1 2 2 2 1 11 13 1
0 0 0 0 0 0 3 0 0 0 0 0 0 7 0 0 0 0 0 0 8 0 8 7 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,252.56 1,006.48 1,108.65 872.52 1,422.72 986.57 2,054.06 1,392.60 960.48 1,030.59 1,000.54 1,289.61 823.48 1,182.61 984.48 932.52 1,054.52 1,113.54 1,391.72 1,213.51 1,629.86 1,366.69 2,626.26 1,927.00 849.39 909.42 1,269.64 981.49 1,294.58 1,851.94 1,837.76 1,285.68 1,413.77 2,185.05 2,055.92 1,194.64 1,525.80 1,232.68 1,650.75 1,318.62 1,492.76 796.40 1,163.62 1,004.53 1,795.90 1,183.64 1,010.58 761.42 1,067.62 1,523.78 717.35
Table S1 page 150/159
Cathepsin D
CATD_HUMAN CTSD
44,535
100.00%
14
16
473
Histidyl-tRNA synthetase, cytoplasmic
SYHC_HUMAN HARS
57,394
100.00%
7
7
16
TITLEVEPSDTIENVK TLSDYNIQK 38.60% AIGAVPLIQGEYMIPCEK DPDAQPGGELMLGGTDSK FDGILGMAYPR ISVNNVLPVFDNLMQQK LVDQNIFSFYLSR QPGITFIAAK QVFGEATK RTMSEVGGSVEDLIAK TMSEVGGSVEDLIAK VGFAEAAR VGFAEAARL VSTLPAITLK YSQAVPAVTEGPIPEVLK YYTVFDRDNNR 16.90% AQLGPDESK ASAELIEEEVAK DQGGELLSLR HGAEVIDTPVFELK IFSIVEQR IGDYVQQHGGVSLVEQLLQDPK
Leukotriene A-4 hydrolase
LKHA4_HUMAN LTA4H
69,269
100.00%
12
12
34
60S acidic ribosomal protein P0
RLA0_HUMAN RPLP0
34,256
100.00%
5
5
18
Cathepsin L1
CATL1_HUMAN CTSL1
37,546
100.00%
6
7
70
Pirin
PIR_HUMAN
32,096
100.00%
5
5
13
PIR
LVSELWDAGIK 29.30% DGETPDPEDPSR DLSSHQLNEFLAQTLQR EDDLNSFNATDLK ELVALMSAIR GSPMEISLPIALSK HFNALGGWGELQNSVK LVVDLTDIDPDVAYSSVPYEK MQEVYNFNAINNSEIR SAYEFSETESMLK SLSNVIAHEISHSWTGNLVTNK SSALQWLTPEQTSGK WEDAIPLALK 23.00% AFLADPSAFVAAAPVAAATTAAPAAAAAPAK GHLENNPALEK GNVGFVFTK IIQLLDDYPK TSFFQALGITTK 22.20% HSFTMAMNAFGDMTSEEFR LYGMNEEGWR MIELHNQEYR NSWGEEWGMGGYVK QVMNGFQNR VFQEPLFYEAPR 18.30% MNPGDLQWMTAGR MVEPQYQELK NLDPFLLFDEFK SEEIPKPSK TPTLYLDFK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
86.7 44.2 82.5 114.0 84.1 61.3 78.4 41.5 34.4 57.0 95.3 64.6 50.2 35.2 98.8 31.4 45.6 74.5 58.1 55.7 71.9 49.2 66.1 35.3 36.9 90.2 66.7 75.6 37.0 99.6 110.0 58.1 57.2 60.9 37.4 47.2 41.4 49.2 76.7 103.0 44.7 55.8 54.0 96.3 60.7 78.0 77.8 34.2 38.8 39.7 41.0
21.8 22.3 22.0 20.3 22.0 20.6 22.6 20.5 22.7 22.8 23.2 25.0 22.9 13.8 19.4 20.3 21.2 23.2 23.7 21.6 20.5 20.3 22.6 16.3 21.8 20.8 21.6 21.5 22.3 21.9 20.7 18.6 20.4 23.3 19.7 18.3 23.5 21.8 22.0 21.7 13.4 20.5 22.5 17.6 21.6 22.0 20.2 22.5 23.0 22.3 21.0
71 3 18 56 74 110 39 7 1 1 67 32 3 3 34 1 2 4 2 2 2 0 2 6 0 2 4 4 0 3 2 2 0 2 2 0 1 2 6 8 0 8 9 4 2 44 4 2 1 4 2
0 0 0 0 0 20 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 0 0 1 0 0 0 4 0 0 1 0 0 0 0 2 0 1 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,787.93 1,081.55 2,005.01 1,803.81 1,239.62 1,959.04 1,601.83 1,045.60 879.46 1,707.86 1,535.76 820.43 933.52 1,042.65 1,898.03 1,462.67 944.47 1,288.66 1,087.58 1,554.82 991.56 2,423.26 1,230.67 1,314.55 2,000.02 1,481.68 1,102.63 1,458.79 1,756.88 2,338.17 1,957.91 1,521.68 2,407.24 1,632.82 1,155.64 2,752.47 1,221.62 968.52 1,217.68 1,313.71 2,240.91 1,254.56 1,332.64 1,615.69 1,109.52 1,495.76 1,492.67 1,280.62 1,497.76 1,014.55 1,097.59
Table S1 page 151/159
Peroxiredoxin-4
PRDX4_HUMAN PRDX4
30,523
100.00%
5
6
15
Bifunctional aminoacyl-tRNA synthetase
SYEP_HUMAN EPRS
170,575
100.00%
3
3
9
Eukaryotic translation initiation factor 3 subunit B
EIF3B_HUMAN EIF3B
92,465
100.00%
6
6
30
Protocadherin-7
PCDH7_HUMAN PCDH7
116,054
100.00%
6
7
14
Coatomer subunit delta
COPD_HUMAN ARCN1
57,193
100.00%
6
6
24
Plastin-2
PLSL_HUMAN LCP1
70,274
100.00%
25
27
141
29.20% DYGVYLEDSGHTLR GLFIIDDK GLFIIDDKGILR IPLLSDLTHQISK LVQAFQYTDK QITLNDLPVGR SVDETLR VSVADHSLHLSK 2.84% DQDLEPGAPSMGAK LTVAENEAETK NQGGGLSSSGAGEGQGPK 9.46% AQAVSEDAGGNEGR GTQGVVTNFEIFR ITNDFYPEEDGKTK MAQELYMEQK TSIFWNDVKDPVSIEER VTLMQLPTR 7.76% LDASEGGGGTNPGGR LFEIDPTSGVVSLVGK RLDASEGGGGTNPGGR SVYEADLAENSAPGTPILQLR VATVLATDADSGK YELLQEPGGGGSGGESR 13.70% GVQLQTHPNVDKK IEGLLAAFPK LFTAESLIGLK NTLEWCLPVIDAK SFPVNSDVGVLK VTQVDGNSPVR 46.90% AACLPLPGYR ALENDPDCR AYYHLLEQVAPK EGESLEDLMK EKDDIQR FSLVGIGGQDLNEGNR GDEEGVPAVVIDMSGLR GSVSDEEMMELR IGNFSTDIK IGNFSTDIKDSK IKVPVDWNR ISFDEFIK KLENCNYAVELGK LSPEELLLR MINLSVPDTIDER NEALIALLR NWMNSLGVNPR QFVTATDVVR TENLNDDEKLNNAK VDTDGNGYISFNELNDLFK VNDDIIVNWVNETLR VYALPEDLVEVNPK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
76.8 47.4 53.2 55.2 58.8 53.0 53.7 59.9 46.5 63.4 77.1 108.0 65.3 32.8 47.5 27.0 65.4 59.6 88.6 45.3 61.6 52.3 62.4 45.2 43.6 64.9 55.3 38.1 71.0 40.5 37.8 52.5 41.0 31.1 86.3 54.7 64.4 48.0 38.9 40.1 45.9 63.0 67.1 66.8 77.8 48.9 65.2 87.2 76.0 97.8 52.8
21.9 20.5 15.6 17.1 21.3 19.9 24.7 21.8 20.2 23.2 21.3 18.6 22.1 20.8 17.6 22.9 22.3 19.2 20.1 21.1 20.9 23.2 22.9 20.8 20.4 16.7 23.1 22.3 22.1 24.2 16.5 22.6 22.0 22.3 22.3 21.4 15.8 21.6 21.7 20.3 20.5 22.8 17.1 22.8 16.0 22.1 23.3 21.4 21.6 21.8 20.8
2 11 9 3 2 4 2 1 3 2 4 15 4 1 2 0 7 2 2 1 1 2 2 1 2 6 1 1 13 2 3 2 1 1 8 7 1 2 1 0 4 2 7 24 6 2 11 7 2 26 2
0 0 5 3 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 2 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,624.76 920.51 1,359.80 1,464.84 1,212.63 1,225.69 819.42 1,292.70 1,431.64 1,204.61 1,587.74 1,360.61 1,467.76 1,656.78 1,302.57 2,035.01 1,058.60 1,344.61 1,660.92 1,500.72 2,244.15 1,247.65 1,692.78 1,463.80 1,058.63 1,191.70 1,558.79 1,261.68 1,171.61 1,117.58 1,089.46 1,431.76 1,150.53 903.45 1,675.84 1,743.86 1,414.58 994.52 1,324.68 1,126.64 998.52 1,537.77 1,069.63 1,518.75 1,012.62 1,287.63 1,135.61 1,617.77 2,161.01 1,799.93 1,585.85
Table S1 page 152/159
YAFVNWINK YPALHKPENQDIDWGALEGETR
Histone-binding protein RBBP4
RBBP4_HUMAN RBBP4
47,638
100.00%
6
6
26
Fatty acid synthase
FAS_HUMAN FASN
273,409
100.00%
14
14
62
Hepatoma-derived growth factor
HDGF_HUMAN HDGF
26,771
100.00%
9
12
59
YTLNILEEIGGGQK 16.50% IGEEQSPEDAEDGPPELLFIHGGHTAK LMIWDTR LNVWDLSK TPSSDVLVFDYTK TVALWDLR VINEEYK 6.69% AAEQYTPK DNLEFFLAGIGR EDGLAQQQTQLNLR FPQLDSTSFANSR GLVQALQTK GNAGQSNYGFANSAMER LPEDPLLSGLLDSPALK LQVVDQPLPVR SEGVVAVLLTK SLLVNPEGPTLMR TPEAVQK VLEALLPLK VLQGDLVMNVYR VVVQVLAEEPEAVLK ISSSDLSLGHVTR SSGFPVHLLPDIAEPGSVAGR 42.50% AGDLLEDSPK DLFPYEESKEK EAATLEVERPLPMEVEK EAENPEGEEK EAENPEGEEKEAATLEVERPLPMEVEK
GFSEGLWEIENNPTVK GPPQEEEEEEDEEEEATKEDAEAPGIR
Caprin-1
CAPR1_HUMAN CAPRIN1
78,346
100.00%
3
3
14
4.23%
Cytoplasmic FMR1-interacting protein 1
CYFP1_HUMAN CYFIP1
145,169
100.00%
6
6
9
5.67%
Niban-like protein 1
NIBL1_HUMAN FAM129B
82,666
99.50%
2
2
6
3.27%
Aldo-keto reductase family 1 member C3
AK1C3_HUMAN AKR1C3
36,827
100.00%
14
16
233
44.60%
IDEMPEAAVK KGFSEGLWEIENNPTVK LDDYQER LNQDQLDAVSK YQEVTNNLEFAK AVGPSSTQLYMVR LGTPQQIAIAR NVIQSVLQAIR SLLQGTILQYVK SSLEGPTILDIEK TVLPFSQEFQR FQELIFEDFAR VQQVQPAMQAVIR AIDGLDR HIDSAHLYNNEEQVGLAIR IADGSVKR LAIEAGFR LNDGHFMPVLGFGTYAPPEVPR QLEMILNKPGLK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0%
34.8 75.4 100.0 62.8 34.4 43.3 89.5 52.7 32.2 36.0 44.6 78.7 70.1 34.6 79.3 87.2 56.2 53.5 50.8 31.6 53.6 63.9 70.3 35.2 51.0 54.7 35.4 42.0 42.8 49.0 68.6 75.4 60.5 92.6 41.3 60.8 52.2 47.8 51.3 43.2 41.5 50.5 42.1 54.6 65.7 30.0 82.9 45.2 46.2 71.0 56.0
20.9 22.0 22.2 20.3 23.5 22.5 23.1 23.2 22.2 23.4 21.6 22.0 22.0 20.0 16.4 17.3 17.2 19.2 21.4 19.8 8.5 22.3 15.1 22.2 21.1 21.2 22.0 22.3 16.1 20.9 23.4 14.6 21.9 21.8 20.1 23.2 22.4 22.7 16.8 17.3 15.7 22.0 21.6 22.6 21.3 23.4 22.0 23.3 23.1 20.9 17.6
1 0 2 0 2 3 5 13 1 1 2 4 9 3 1 7 8 4 4 1 7 2 9 1 0 1 2 2 2 0 17 0 15 3 2 5 7 1 2 1 1 2 2 2 4 1 0 1 52 1 9
0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 2 1 7 0 5 0 0 0 0 0 0 0 0 0 0 0 0 56 0 0 6 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,154.60 2,539.22 1,534.81 2,873.36 934.48 974.53 1,471.73 973.55 894.46 907.45 1,351.70 1,613.83 1,469.70 957.57 1,789.76 1,778.00 1,263.74 1,115.67 1,442.77 772.42 995.65 1,422.74 1,622.94 1,371.72 2,106.10 1,044.52 1,384.66 1,957.00 1,131.48 3,053.46 1,819.89 3,042.28 1,118.54 1,947.98 938.42 1,230.63 1,455.71 1,424.72 1,167.69 1,240.74 1,362.80 1,401.75 1,351.70 1,414.70 1,483.81 759.40 2,179.09 845.48 876.49 2,430.19 1,383.80
Table S1 page 153/159
REDIFYTSK RQLEMILNKPGLK RTPALIALR SIGVSNFNR SKDIVLVAYSALGSQR TPALIALR WVDPNSPVLLEDPVLCALAK YQLQR EGFVEYTEQVVK LLSSAFDEVYPALPSDVQTAIK LVLEQVVTSIASVADTAEEK NLIDEDGNNQWPEGLK NTTAAEEAR SLVEIADTVPK VCDIAAELAR VIAALLQTMEDQGNQR DIQLENYTPK DIQLENYTPKEPLTLQAR EPLTLQAR EVVDILTEQLR MWTTVHPGAR IAQSDYIPTQQDVLR LLLLGAGESGK ADSYYEYLLK IPYSDVNIGTGVAHPPR QETQLLEDYVEAIEGVR VPSGGYSSINNVQDPQKPEPR DIVQFVPYR EALAQTVLAEVPTQLVSYFR FGIYDIDNK FQNAPR LYGPTNFAPIINHVAR SDPFLEFFR GQSEVSAAQLQER IAVAGDLFQPER LLDLDEAAYK AFGYYGPLR NPPGFAFVEFEDPR NPPGFAFVEFEDPRDAADAVR VYVGNLGNNGNKTELER
Importin-5
IPO5_HUMAN IPO5
123,614
100.00%
8
9
18
10.60%
NKG2D ligand 2
N2DL2_HUMAN ULBP2
27,351
100.00%
5
6
66
15.90%
Guanine nucleotide-binding protein G(i) subunit alpha-2 Endoplasmic reticulum mannosyloligosaccharide 1,2-alphamannosidase
GNAI2_HUMAN GNAI2
40,434
99.50%
2
2
5
7.32%
MA1B1_HUMAN MAN1B1
79,564
100.00%
4
4
10
9.30%
Copine-1
CPNE1_HUMAN CPNE1
59,041
100.00%
6
6
14
12.80%
Growth arrest-specific protein 6
GAS6_HUMAN GAS6
79,658
100.00%
3
3
13
4.85%
Splicing factor, arginine/serine-rich 3 SFRS3_HUMAN SFRS3
19,312
100.00%
4
5
24
28.70%
CALR_HUMAN CALR
48,125
100.00%
14
20
158
44.40% AKIDDPTDSKPEDWDKPEHIPDPDAK EQFLDGDGWTSR FYALSASFEPFSNK FYGDEEKDK GLQTSQDAR
Calreticulin
IDDPTDSKPEDWDKPEHIPDPDAK
IDNSQVESGSLEDDWDFLPPK IDNSQVESGSLEDDWDFLPPKK IKDPDASKPEDWDER KPEDWDEEMDGEWEPPVIQNPEYK
KVHVIFNYK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
38.6 28.1 37.6 53.8 60.2 70.5 86.9 30.5 44.9 48.1 108.0 60.5 37.3 59.9 32.8 81.9 59.5 94.6 37.6 87.0 38.2 52.5 57.8 41.7 35.2 81.6 40.8 45.7 76.4 42.5 31.9 36.9 71.8 110.0 74.3 50.4 54.3 79.2 54.6 27.7 37.9 66.6 103.0 47.9 55.9 31.7 137.0 97.1 66.3 63.1 28.1
21.6 14.5 10.0 22.6 18.8 14.8 21.1 22.5 22.4 20.3 19.7 22.4 21.3 22.7 23.3 22.3 23.4 20.8 19.0 22.4 21.1 22.2 20.1 22.7 21.5 22.0 22.0 22.5 17.4 22.2 23.0 20.6 21.0 22.7 22.5 22.0 22.3 22.1 21.4 22.6 20.5 19.7 21.9 18.4 23.0 19.5 20.2 21.5 21.8 17.1 18.3
15 0 2 6 0 31 2 2 1 1 2 1 2 4 2 4 6 7 5 38 4 2 3 2 0 2 0 2 3 2 1 0 4 5 4 4 8 7 3 0 0 29 13 4 5 0 11 6 5 0 0
0 2 0 0 26 0 0 0 0 0 1 0 0 0 0 0 0 6 0 0 0 0 0 0 2 0 4 0 0 0 0 2 0 0 0 0 0 0 5 1 3 0 0 3 0 1 0 51 2 13 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 1 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,158.58 1,539.90 1,010.65 993.51 1,706.94 854.55 2,236.17 707.38 1,427.71 2,364.23 2,102.12 1,841.87 962.45 1,171.66 1,117.57 1,802.91 1,220.62 2,129.12 927.53 1,314.73 1,171.57 1,746.90 1,057.63 1,264.61 1,792.93 1,991.99 2,269.12 1,136.61 2,235.20 1,084.53 732.38 1,782.97 1,157.56 1,402.69 1,315.70 1,150.60 1,043.53 1,621.77 2,320.10 1,876.95 2,959.40 1,410.63 1,607.77 1,130.50 975.49 2,760.26 2,391.10 2,519.19 1,800.84 2,976.29 1,147.66
Table S1 page 154/159
LFPNSLDQTDMHGDSEYNIMFGPDICGPGTK
Tubulointerstitial nephritis antigenlike
TINAL_HUMAN TINAGL1
52,369
100.00%
16
17
194
NVLINK QIDNPDYK 48.00% ELAPGLHLR ELMENGPVQALMEVHEDFFLYK
GGIYSHTPVSLGRPER GVNECDIESFVLGVWGR GVVSDHCYPFSGR HGTHSVK ITGWGEETLPDGR IYPVLGTYWDNCNR LDGAWWFLR LGSNDKEIMK LGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEK
QATAHCPNSYVNNNDIYQVTPVYR
Adenosine kinase
ADK_HUMAN ADK
40,529
100.00%
4
4
6
11.30%
Pigment epithelium-derived factor
PEDF_HUMAN SERPINF1
46,326
100.00%
7
7
23
19.90%
Reticulocalbin-2
RCN2_HUMAN RCN2
36,860
99.50%
2
2
4
12.30%
DNA damage-binding protein 1
DDB1_HUMAN DDB1
126,952
100.00%
21
22
64
19.70%
RELAPGLHLR VGMEDMGHH YCQEQDLCCR YWTAANSWGPAWGER ELFDELVK IVIFTQGR VAQWMIQQPHK YSLKPNDQILAEDK DTDTGALLFIGK ELLDTVTAPQK LAAAVSNFGYDLYR LDLQEINNWVQAQMK LQSLFDSPDFSK LTQVEHR TSLEDFYLDEER LSEEEILENPDLFLTSEATDYGR WDPTANEDPEWILVEK ALVSEWKEPQAK ALYYLQIHPQELR DSAATTDEER EATADDLIK EMLGGEIIPR GDFILVGDLMR IAVMELFRPK IEVQDTSGGTTALRPSASTQALSSSVSSSK
IVVFQYSDGK LEELHVIDVK LPSFELLHK LQTVAEK LVFSNVNLK LVSQEPK LYEWTTEK QGQGQLVTCSGAFK TVPLYESPR VTLGTQPTVLR VVEELTR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
56.1 30.6 51.7 44.1 27.5 33.0 43.6 62.7 42.6 90.1 78.4 73.5 34.3 35.0 55.6 56.2 38.2 50.7 82.9 34.3 33.7 27.6 32.2 81.0 41.5 72.0 56.2 69.2 63.7 61.2 45.2 52.1 53.9 34.2 57.8 32.6 63.9 46.7 66.8 47.2 63.5 54.0 32.9 30.7 49.2 33.2 30.6 78.1 37.0 74.0 39.9
15.6 22.0 22.1 18.5 21.0 21.2 21.8 19.9 22.6 22.2 21.4 23.1 22.8 19.3 21.0 16.8 12.0 9.5 22.3 20.9 19.6 22.7 22.2 22.3 22.6 23.1 22.3 22.7 21.0 19.6 21.0 20.8 21.7 20.5 16.5 23.3 22.0 22.8 18.3 20.3 21.7 18.6 19.5 23.7 17.6 21.1 20.5 22.1 22.3 19.2 23.4
0 1 5 7 0 1 3 4 4 51 11 75 3 0 0 0 3 5 9 1 3 0 0 6 4 2 2 6 1 2 1 3 2 0 4 2 8 2 2 0 4 2 1 1 4 1 1 2 1 15 3
2 0 0 0 1 0 0 0 0 0 0 0 11 1 2 3 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 5 0 0 1 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
3,488.51 700.44 992.47 1,005.58 2,671.24 1,725.90 1,936.92 1,480.66 765.40 1,430.69 1,770.83 1,163.60 1,150.58 3,849.90 2,824.31 1,161.69 1,028.39 1,431.55 1,751.79 992.53 933.55 1,365.71 1,633.84 1,250.66 1,214.66 1,559.79 1,845.92 1,383.68 882.48 1,516.68 2,641.25 1,941.92 1,385.74 1,643.89 1,094.46 975.50 1,114.59 1,235.65 1,203.69 2,952.48 1,155.61 1,194.67 1,083.62 788.45 1,033.60 800.45 1,069.52 1,480.72 1,061.56 1,184.70 845.47
Table S1 page 155/159
Protein FAM3C
FAM3C_HUMAN FAM3C
24,663
100.00%
11
13
412
54.60%
60S ribosomal protein L22
RL22_HUMAN RPL22
14,769
99.50%
2
2
3
18.80%
Sortilin
SORT_HUMAN SORT1
92,052
99.50%
2
2
2
2.29%
Heterogeneous nuclear ribonucleoprotein A1
ROA1_HUMAN HNRNPA1
38,729
100.00%
10
14
257
39.50%
YLAIAPPIIK YLLGDMEGR AIQDGTIVLMGTYDDGATK GINVALANGK ICLEDNVLMSGVK LIADLGSTSITNLGFR MASGAANVVGPK MDASLGNLFAR SALDTAAR SPFEQHIK TGEVLDTK TKSPFEQHIK YFDMWGGDVAPFIEFLK AGNLGGGVVTIER ITVTSEVPFSK ADLGALELWR IYSFGLGGR DYFEQYGK EDSQRPGAHLTVK EDTEEHHLR GFAFVTFDDHDSVDK GFGFVTYATVEEVDAAMNARPHK
Basic leucine zipper and W2 domain-containing protein 1
BZW1_HUMAN BZW1
Testin
TES_HUMAN
Fascin
FSCN1_HUMAN FSCN1
TES
48,027
100.00%
4
4
10
47,978
100.00%
4
4
17
54,512
100.00%
25
32
511
IEVIEIMTDR IFVGGIK IFVGGIKEDTEEHHLR KLFIGGLSFETTDESLR LFIGGLSFETTDESLR NQGGYGGSSSSSSYGSGR SESPKEPEQLR SSGPYGGGGQYFAKPR 8.83% AEVLSEEPILK DINAVAASLR GFSESER LMELFPANK 10.90% EGDPAIYAER NVMILTNPVAAK QPVAGSEGAQYR STPAAVGAMEDK 61.30% DVPWGVDSLITLAFQDQR FLIVAHDDGR GDHAGVLK KVTGTLDANR LINRPIIVFR LSCFAQTVSPAEK LVARPEPATGYTLEFR NGQLAASVETAGDSELFLMK QGMDLSANQDEETDQETFQLEIDR QGMDLSANQDEETDQETFQLEIDRDTK
QIWTLEQPPDEAGSAAVCLR SSYDVFQLEFNDGAYNIK VGKDELFALEQSCAQVVLQAANER
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
31.1 42.5 145.0 52.1 77.2 149.0 92.1 81.6 64.1 57.2 48.8 38.0 62.0 48.1 58.1 64.7 30.5 47.3 59.3 44.3 78.1 32.7 72.2 34.6 41.6 47.9 124.0 128.0 49.8 99.9 73.6 43.6 35.8 34.2 41.7 70.3 36.2 48.5 51.9 57.9 50.2 44.6 46.0 99.6 65.3 82.5 48.1 83.5 90.4 115.0 72.7
16.0 23.0 22.3 20.2 23.2 19.5 21.8 23.3 23.6 20.8 24.6 21.1 21.2 22.9 22.0 22.6 21.5 19.2 22.1 20.9 20.1 22.0 23.6 16.5 21.8 21.6 21.4 15.7 21.9 21.7 20.2 21.3 17.7 23.6 22.6 20.3 23.0 22.0 21.6 22.4 18.9 23.2 10.4 21.8 20.7 22.1 16.5 16.8 21.6 21.5 20.8
1 1 143 3 10 133 60 6 9 25 6 0 2 1 2 1 1 9 22 5 25 0 33 1 0 2 99 14 18 4 4 2 1 3 1 6 2 8 1 17 3 4 4 9 24 20 0 0 4 34 0
0 0 1 0 0 8 0 0 0 0 0 6 0 0 0 0 0 0 0 0 2 0 0 0 17 1 0 0 20 1 0 0 0 0 0 0 0 0 0 11 0 1 33 0 69 0 5 10 0 0 10
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,098.69 1,053.50 1,984.95 956.55 1,493.73 1,677.92 1,101.57 1,194.59 804.42 985.51 862.45 1,214.65 2,050.96 1,242.68 1,207.66 1,143.62 969.52 1,049.46 1,437.75 1,165.52 1,699.76 2,526.21 1,234.64 733.46 1,879.97 1,913.00 1,784.91 1,694.70 1,299.65 1,628.78 1,227.68 1,029.57 811.36 1,062.57 1,120.53 1,270.72 1,262.61 1,192.55 2,060.05 1,142.60 796.43 1,074.59 1,240.79 1,437.70 1,819.97 2,097.02 2,828.22 3,172.39 2,241.10 2,109.98 2,675.35
Table S1 page 156/159
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
DDAH1_HUMAN DDAH1
31,104
100.00%
7
8
29
33.00%
Proteasome subunit beta type-6
PSB6_HUMAN PSMB6
25,340
100.00%
6
7
28
21.30%
Ribosyldihydronicotinamide dehydrogenase [quinone] Alpha-centractin
NQO2_HUMAN NQO2
25,935
99.50%
2
3
5
13.00%
ACTZ_HUMAN ACTR1A
42,597
100.00%
3
3
4
12.50%
Amyloid beta A4 protein
A4_HUMAN
86,923
100.00%
16
19
237
22.60%
Thioredoxin domain-containing protein 17
TXD17_HUMAN TXNDC17
13,922
100.00%
5
6
16
43.90%
APP
VNASASSLK VNASASSLKK VTGTLDANR WSLQSEAHR YAHLSARPADEIAVDR YFGGTEDR YLAADKDGNVTCER YLAPSGPSGTLK YLKGDHAGVLK YLTAEAFGFK YSVQTADHR YWTLTATGGVQSTASSK ALPESLGQHALR DYAVSTVPVADGLHLK GAEILADTFK SAKGEEVDVAR SFCSMAGPNLIAIGSSESAQK TPEEYPESAK VDGLLTCCSVLINK DGSSGGVIR LAAIAESGVER LTPIHDR QVLLGDQIPK TTTGSYIANR VTDKLTPIHDR SLASDITDEQKK VLAPQISFAPEIASEEER AQYYLPDGSTIEIGPSR DQLQTFSEEHPVLLTEAPLNPR EYEEDGAR AVIQHFQEKVESLEQEAANER CAPFFYGGCGGNR CLVGEFVSDALLVPDK EQNYSDDVLANMISEPR ISYGNDALMPSLTETK LALENYITALQAVPPRPR MDAEFR MSQVMR MSQVMREWEEAER QQLVETHMAR SQVMTHLR THPHFVIPYR VEAMLNDR VESLEQEAANER WDSDPSGTK WYFDVTEGK DPNNDFR SWCPDCVQAEPVVR TIFAYFTGSK VTAVPTLLK YEEVSVSGFEEFHR
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
62.8 51.6 60.7 57.7 18.8 51.8 81.6 44.2 47.3 45.8 66.2 149.0 37.3 76.4 51.5 47.0 73.3 61.9 81.4 76.0 98.9 31.2 34.5 67.8 48.7 62.2 78.4 35.4 39.9 33.1 51.5 31.8 83.1 109.0 90.6 85.2 32.5 37.9 33.3 47.2 31.2 36.9 57.2 79.8 40.1 43.8 32.0 84.4 43.0 40.8 54.4
22.9 18.9 23.6 22.0 22.0 17.0 21.0 22.5 22.3 23.8 22.2 22.4 20.8 21.8 23.3 23.5 21.6 21.0 22.7 23.6 23.0 20.7 17.8 22.0 21.0 23.0 21.4 22.1 20.3 16.2 20.6 13.4 22.8 19.6 21.8 14.1 17.9 20.2 18.7 21.9 21.4 21.4 21.9 21.3 19.2 19.8 18.1 19.9 23.8 11.8 20.3
8 7 12 21 0 8 2 3 3 12 24 140 2 3 2 2 2 12 2 4 8 1 1 10 2 2 2 1 0 1 0 2 3 27 16 2 2 2 0 2 2 0 32 33 3 8 2 2 3 4 2
0 0 0 1 0 0 0 0 9 0 1 0 0 0 0 4 0 0 0 0 0 0 0 0 2 0 1 0 2 0 11 0 0 2 0 59 0 0 1 2 0 28 0 0 0 0 0 0 0 0 3
0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
876.48 1,004.57 946.50 1,113.54 1,783.91 944.41 1,611.74 1,190.64 1,200.67 1,146.58 1,076.51 1,757.87 1,291.71 1,684.89 1,064.56 1,160.59 2,155.02 1,150.53 1,591.82 847.43 1,115.61 851.47 1,110.65 1,083.54 1,294.71 1,334.68 1,986.02 1,866.92 2,534.29 968.40 2,455.22 1,462.60 1,761.91 1,996.89 1,739.85 2,022.15 768.34 767.35 1,712.74 1,212.62 971.51 1,266.67 963.46 1,374.65 992.43 1,144.53 877.38 1,702.77 1,134.58 941.60 1,714.77
Table S1 page 157/159
Complement C3
CO3_HUMAN C3
187,131
100.00%
33
35
98
25.60% ADIGCTPGSGK AEDLVGK AGDFLEANYMNLQR APSTWLTAYVVK AYYENSPQQVFSTEFEVK EYVLPSFEVIVEPTEK FYYIYNEK GYTQQLAFR ILLQGTPVAQMTEDAVDAER IPIEDGSGEVVLSR ISLPESLKR KQELSEAEQATR LVAYYTLIGASGQR NTMILEICTR QELSEAEQATR QLANGVDR QNQELK QPSSAFAAFVK SEETKENEGFTVTAEGK SGQSEDRQPVPGQQMTLK SGSDEVQVGQQR SNLDEDIIAEENIVSR SSLSVPYVIVPLK TIYTPGSTVLYR TMQALPYSTVGNSNNYLHLSVLR
TVMVNIENPEGIPVK VFLDCCNYITELR VHQYFNVELIQPGAVK VLLDGVQNPR VPVAVQGEDTVQSLTQGDGVAK
Sushi repeat-containing protein SRPX2
SRPX2_HUMAN SRPX2
52,954
100.00%
4
4
26
11.00%
Fumarylacetoacetase
FAAA_HUMAN FAH
46,358
100.00%
4
4
9
10.50%
27,350
100.00%
2
2
6
13.90%
22,970
100.00%
10
12
74
62.70%
Splicing factor, arginine/serine-rich 7 SFRS7_HUMAN SFRS7
Rho GDP-dissociation inhibitor 2
GDIR2_HUMAN ARHGDIB
VQLSNDFDEYIMAIEQTIK VTIKPAPETEK YYTYLIMNK DSADGTITR EQQLSANIIEELR HVTIIELVGQPPQEVGR LLIISAPDPSNR ASSVVVSGTPIR HLFTGPVLSK LGEPIPISK VFLQNLLSVSQAR NPPGFAFVEFEDPR NPPGFAFVEFEDPRDAEDAVR VYVGNLGTGAGK APEPHVEEDDDDELDSK APEPHVEEDDDDELDSKLNYKPPPQK
APNVVVTR ATFMVGSYGPRPEEYEFLTPVEEAPK
ELQEMDKDDESLIK LNYKPPPQK LTLVCESAPGPITMDLTGDLEALKK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
45.8 41.6 71.1 53.1 74.1 81.1 37.2 48.3 119.0 100.0 32.7 73.7 54.1 34.6 58.8 68.4 39.3 31.7 31.4 49.3 71.4 91.5 54.2 37.9 34.3 50.9 65.7 32.3 52.4 90.8 133.0 40.1 37.5 53.9 62.1 34.5 55.1 79.4 34.2 34.9 84.4 79.2 36.5 42.8 103.0 21.0 52.3 61.1 64.9 28.2 31.3
21.2 24.4 21.5 20.4 21.3 21.1 22.6 21.5 21.9 22.0 18.6 22.9 20.5 22.8 22.3 21.3 23.4 22.6 21.5 21.6 21.1 22.3 12.0 21.1 20.6 21.5 20.9 19.8 20.2 21.4 21.2 19.3 22.5 22.9 21.8 18.1 17.4 22.4 18.6 14.9 18.4 22.1 20.5 22.8 16.2 20.4 18.1 21.8 23.0 19.8 20.8
1 2 7 2 3 4 2 3 10 2 1 2 3 1 2 2 1 1 0 2 10 4 9 1 0 2 2 0 2 3 2 1 2 6 1 0 15 4 2 1 2 7 0 2 4 0 13 0 11 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 0 0 2 0 2 0 2 0 0 0 4 0 0 0 0 0 0 4 0 4 0 0 12 1 4 3
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1,062.49 731.39 1,657.76 1,335.73 2,166.00 1,878.97 1,139.54 1,083.56 2,173.08 1,470.78 1,042.63 1,389.70 1,511.82 1,266.62 1,261.60 872.46 759.40 1,152.61 1,855.86 2,001.97 1,289.61 1,816.89 1,401.84 1,370.73 2,594.30 1,655.87 1,702.79 1,841.99 1,110.63 2,198.13 2,273.10 1,212.68 1,224.60 935.44 1,542.81 1,872.03 1,295.73 1,172.66 1,098.63 953.57 1,474.84 1,621.77 2,378.11 1,135.61 1,939.80 3,005.40 855.51 2,960.40 1,692.80 1,084.62 2,688.38
Table S1 page 158/159
Peroxiredoxin-1
PRDX1_HUMAN PRDX1
22,093
100.00%
14
17
183
55.30%
Proteasome subunit alpha type-3
PSA3_HUMAN PSMA3
28,416
100.00%
10
11
77
37.60%
Tyrosine-protein kinase-like 7
PTK7_HUMAN PTK7
118,374
100.00%
6
6
13
7.38%
Syntaxin-12
STX12_HUMAN STX12
31,625
99.50%
2
2
2
10.50%
Apolipoprotein B-100
APOB_HUMAN APOB
515,554
100.00%
2
2
4
0.48%
TGVKVDK TLLGDGPVVTDPK YVQHTYR ADEGISFR AEEFKK ATAVMPDGQFK DISLSDYK GLFIIDDK GLFIIDDKGILR IGHPAPNFK KQGGLGPMNIPLVSDPK LVQAFQFTDK QGGLGPMNIPLVSDPK QGGLGPMNIPLVSDPKR QITVNDLPVGR SVDETLR TIAQDYGVLK AVENSSTAIGIR DIREEAEK EEASNFR ESLKEEDESDDDNM HEIVPK HVGMAVAGLLADAR LYEEGSNKR SLADIAR SNFGYNIPLK VFQVEYAMK ADGSSLPEWVTDNAGTLHFAR DDVTGEEAR HPASEAEIQPQTQVTLR QPSSQDALQGR VFTAGSEER VVLAPQDVVVAR ELGSLPLPLSTSEQR QLEADILDVNQIFK IEGNLIFDPNNYLPK NLLVALK
95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%
35.2 73.8 37.0 59.6 30.6 58.5 37.4 47.4 53.2 45.3 54.7 67.5 108.0 62.5 82.9 53.7 60.4 92.8 39.4 45.5 77.1 34.8 81.5 48.6 31.3 58.0 57.8 37.8 48.7 29.8 47.2 35.6 48.0 37.3 45.5 31.6 41.8
22.4 20.9 22.1 22.6 23.1 22.6 21.6 20.5 15.6 21.7 18.2 21.2 22.0 19.6 21.0 24.7 21.7 23.2 22.9 21.0 8.5 19.9 21.8 21.4 25.5 22.3 21.9 22.0 15.9 22.5 21.8 21.3 14.5 20.8 21.1 21.7 12.0
1 15 5 12 1 19 5 11 9 1 3 54 17 3 23 2 14 11 4 4 14 3 6 4 1 12 10 0 2 0 4 1 3 1 1 2 2
0 0 0 0 0 0 0 0 5 0 1 0 0 3 0 0 0 0 0 0 0 0 8 0 0 0 0 1 0 2 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
746.44 1,311.72 966.48 894.43 751.40 1,180.57 940.46 920.51 1,359.80 980.53 1,750.95 1,196.63 1,638.85 1,778.96 1,211.68 819.42 1,107.61 1,217.65 989.49 852.39 1,671.62 722.42 1,396.74 1,095.54 745.42 1,152.61 1,130.56 2,244.07 991.43 1,904.98 1,186.58 995.48 1,265.76 1,626.87 1,645.88 1,746.91 770.51
Table S1 page 159/159