Supporting Table S1.xlsx

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Protein name

Accession No.

Apolipoprotein A-I-binding protein

AIBP_HUMAN APOA1BP

Kunitz-type protease inhibitor 1

SPIT1_HUMAN SPINT1

DNA replication licensing factor MCM2 Multifunctional protein ADE2

MCM2_HUMAN MCM2

Matrilysin

MMP7_HUMAN MMP7

Antithrombin-III

ANT3_HUMAN SERPINC1

Tumor protein D52

TPD52_HUMAN TPD52

Histone H2B type 1-C/E/F/G/I

H2B1C_HUMAN HIST1H2BC

Kynureninase

KYNU_HUMAN KYNU

Gene symbol

PUR6_HUMAN PAICS

Serine/threonine-protein phosphatase PP2BA_HUMAN PPP3CA 2B catalytic subunit alpha isoform

Heterogeneous nuclear ribonucleoproteins A2/B1

ROA2_HUMAN HNRNPA2B1

Supporting Table S1. List of proteins identified in the BxPC-3 conditioned medium No. of No. of Molecular Protein Spectral Sequence Peptide sequence unique unique weight (Da) probability counts coverage peptides spectra 20.10% GLTVPIASIDIPSGWDVEK 8 4 4 100.00% 31,657 GNAGGIQPDLLISLTAPK KSATQFTGR LFGYEPTIYYPK 20.20% AWAGIDLK 77 11 10 100.00% 58,379 DPNQVELWGLK EGFINYLTR GSSGAQATFPQGPSMER KDPNQVELWGLK SFVYGGCLGNK TQGFGGSGIPK VQPQEPLVLKDVENTDWR WYYDPTEQICK YTSGFDELQR 2.65% GLALALFGGEPK 4 2 2 100.00% 101,880 VAVGELTDEDVK 6.35% EIVLADVIDNDSWR 3 2 2 99.50% 47,062 VTSAHKGPDETLR 9.74% DLPHITVDR 4 3 3 100.00% 29,660 FYLYDSETK NANSLEAK 10.60% FDTISEK 43 7 7 100.00% 52,586 FSPENTR FSPENTRK LPGIVAEGR LQPLDFK RVWELSK TSDQIHFFFAK 16.10% LGINSLQELK 5 3 3 100.00% 24,310 TSETLSQAGQK VEEEIQTLSQVLAAK 38.90% AMGIMNSFVNDIFER 17 5 5 100.00% 13,889 EIQTAVR IAGEASR LLLPGELAK QVHPDTGISSK 11.40% FTNLLTSILDSAETK 12 5 5 100.00% 52,335 FTNLLTSILDSAETKN IAAYGHEVGK TYLEEELDKWAK VAPVPLYNSFHDVYK 10.20% DAMPSDANLNSINK 7 4 4 100.00% 58,672 GLTPTGMLPSGVLSGGK IITEGASILR LFEVGGSPANTR 43.60% DYFEEYGK 314 20 17 100.00% 37,412 EDTEEHHLR

Peptide probability 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

Mascot Mascot No. of identified spectra No. of Calculated ion identity 2+ tryptic 3+ 4+ MH+ score score spectra spectra spectra termini 47.3 20.1 3 0 0 2 1,997.06 64.2 17.8 2 0 0 2 1,764.99 36.0 21.6 1 0 0 2 995.53 51.2 23.9 2 0 0 2 1,490.76 31.2 24.8 1 0 0 2 873.48 45.8 21.3 2 0 0 2 1,298.67 53.5 22.0 26 0 0 2 1,112.57 67.5 18.5 16 0 0 2 1,723.77 69.1 20.6 7 4 0 2 1,426.77 49.7 21.8 2 0 0 2 1,201.57 37.8 23.4 4 0 0 2 1,048.54 94.9 21.5 1 0 0 2 2,166.12 37.0 19.0 2 0 0 2 1,502.66 61.5 20.6 12 0 0 2 1,215.56 68.1 21.6 2 0 0 2 1,172.67 64.2 23.0 2 0 0 2 1,274.65 36.8 22.4 1 0 0 2 1,644.82 23.8 21.9 0 0 2 2 1,410.73 31.8 21.6 1 0 0 2 1,065.57 30.2 22.6 1 0 0 2 1,165.54 40.7 22.4 2 0 0 2 846.43 44.1 22.4 11 0 0 2 839.42 32.0 23.8 2 0 0 2 850.41 32.2 23.6 1 0 0 2 978.50 49.2 19.0 13 0 0 2 911.53 34.7 23.9 2 0 0 2 860.49 33.6 22.4 4 0 0 2 917.52 57.3 22.1 10 0 0 2 1,340.66 40.3 21.5 1 0 0 2 1,114.65 62.2 23.1 2 0 0 2 1,149.58 55.2 20.9 2 0 0 2 1,657.90 114.0 21.8 13 0 0 2 1,743.82 34.3 23.8 1 0 0 2 816.46 41.5 24.5 1 0 0 2 703.37 32.5 13.8 1 0 0 2 953.60 45.9 22.5 0 1 0 2 1,168.60 101.0 21.6 4 0 0 2 1,652.87 62.8 21.4 4 0 0 2 1,766.92 64.8 22.5 2 0 0 2 1,044.55 38.9 23.1 1 0 0 2 1,524.76 44.0 22.5 1 0 0 2 1,748.90 39.2 19.9 2 0 0 2 1,505.69 61.0 22.2 2 0 0 2 1,587.84 45.4 19.3 1 0 0 2 1,072.64 48.4 23.8 2 0 0 2 1,247.64 33.2 15.4 2 0 0 2 1,050.44 44.3 20.9 5 0 0 2 1,165.52 Table S1 page 1/159

Glutaredoxin-3

GLRX3_HUMAN GLRX3

37,415

100.00%

5

5

8

17.90%

Laminin subunit gamma-1

LAMC1_HUMAN LAMC1

177,583

100.00%

26

29

355

19.20%

Flap endonuclease 1

FEN1_HUMAN FEN1

42,576

100.00%

4

4

9

15.30%

Phosphoserine phosphatase

SERB_HUMAN PSPH

24,990

100.00%

2

2

2

11.60%

EESGKPGAHVTVK GFGFVTFDDHDPVDK GFGFVTFDDHDPVDKIVLQK GGGGNFGPGPGSNFR GGNFGFGDSR GGSDGYGSGR IDTIEIITDR KLFIGGLSFETTEESLR LFIGGLSFETTEESLR LFVGGIK LFVGGIKEDTEEHHLR LTDCVVMR NYYEQWGK QEMQEVQSSR TLETVPLER AYSNWPTYPQLYVK ENGELLPILR GELVGGLDIVK LEAEGVPEVSEK YEISSVPTFLFFK AFDITYVR AHVENTER ALAEEAAK CELCDDGYFGDPLGR CIYNTAGFYCDR DGFFGNPLAPNPADK DGSEASLEWSSER DTLQEANDILNNLK EAQDVKDVDQNLMDR EAQQALGSAAADATEAK EVVCTNCPTGTTGK GKTEQQTADQLLAR HKQEADDIVR LIEIASR LNEIEGTLNK LNTFGDEVFNDPK LSAEDLVLEGAGLR MEAENLEQLIDQK NTIEETGNLAEQAR QDIAVISDSYFPR QLQEAEK TEQQTADQLLAR TFAEVTDLDNEVNNMLK TGQCECQPGITGQHCER TKEVVCTNCPTGTTGK VSVPLIAQGNSYPSETTVK EAHQLFLEPEVLDPESVELK KLPIQEFHLSR LIADVAPSAIR QLQQAQAAGAEQEVEK LIAEQPPHLTPGIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

55.6 86.5 39.2 66.3 63.1 74.0 101.0 80.3 109.0 34.6 41.6 35.6 37.4 68.4 40.4 32.0 46.4 35.5 43.9 44.0 54.3 34.5 48.1 71.6 33.8 71.3 73.9 79.1 45.7 133.0 41.7 88.3 47.0 53.3 52.3 88.2 123.0 92.1 98.8 88.3 39.5 60.2 110.0 69.2 57.1 109.0 43.2 27.6 54.0 107.0 32.1

22.6 20.5 21.3 21.1 17.4 16.1 23.1 20.7 21.8 16.5 21.8 22.9 19.1 19.7 20.9 22.2 19.1 21.6 22.8 22.6 21.6 20.7 21.6 14.1 14.6 21.8 16.5 21.6 22.1 22.7 19.8 22.9 23.1 22.3 24.2 22.7 21.8 21.8 22.3 22.8 22.0 22.6 21.6 14.5 21.7 20.5 20.8 17.6 17.2 22.1 17.6

8 23 0 24 19 2 30 2 112 1 0 2 2 29 11 1 2 2 2 1 12 1 9 2 1 16 5 9 3 26 1 5 0 4 9 36 58 20 21 20 1 2 13 0 1 36 0 0 3 3 0

0 14 9 0 0 0 0 1 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 6 0 0 23 0 0 0 2 0 0 0 0 0 0 11 0 0 2 1 0 0 1

0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,338.70 1,695.77 2,277.16 1,377.63 1,013.44 912.38 1,188.65 1,927.02 1,798.92 733.46 1,879.97 993.49 1,087.48 1,237.55 1,057.59 1,729.86 1,153.66 1,099.64 1,286.65 1,577.83 984.52 955.46 802.43 1,773.72 1,539.64 1,559.75 1,452.62 1,600.82 1,791.82 1,631.79 1,523.68 1,558.82 1,210.62 801.48 1,130.61 1,495.71 1,442.79 1,576.75 1,545.75 1,510.75 845.44 1,373.70 1,968.92 2,017.83 1,752.83 1,990.05 2,322.19 1,367.78 1,125.66 1,727.86 1,541.88

Table S1 page 2/159

Complement C1r subcomponent

C1R_HUMAN C1R

80,102

100.00%

14

14

67

LNIPATNVFANR 22.60% FCGQLGSPLGNPPGK FCGQLGSPLGNPPGKK GGGALLGDR IAHDLR LGNHPIR LPVANPQACENWLR MGNFPWQVFTNIHGR QDACQGDSGGVFAVR QRPPDLDTSSNAVDLLFFTDESGDSR

TLDEFTIIQNLQPQYQFR VLNYVDWIK VLNYVDWIKK WILTAAHTLYPK YTTTMGVNTYK Eukaryotic translation initiation factor 3 subunit A

EIF3A_HUMAN EIF3A

166,557

100.00%

3

3

4

Crk-like protein

CRKL_HUMAN CRKL

33,759

100.00%

2

2

3

Rap1 GTPase-GDP dissociation stimulator 1 Eukaryotic initiation factor 4A-III

GDS1_HUMAN RAP1GDS1

66,300

99.90%

2

2

3

IF4A3_HUMAN EIF4A3

46,854

100.00%

4

4

6

T-complex protein 1 subunit alpha

TCPA_HUMAN TCP1

60,327

100.00%

8

9

17

3.62% EQPEKEPELQQYVPQLQNNTILR FNVLQYVVPEVK LTSLVPFVDAFQLER 8.91% IHYLDTTTLIEPAPR TALALEVGDIVK 4.28% EQFASTNIAEELVK SVAQQASLTEQR 16.50% ETQALILAPTR GIYAYGFEKPSAIQQR GRDVIAQSQSGTGK LDYGQHVVAGTPGR MLVLDEADEMLNK 18.50% AFHNEAQVNPER AFHNEAQVNPERK FATEAAITILR MLVDDIGDVTITNDGATILK QAGVFEPTIVK SLLVIPNTLAVNAAQDSTDLVAK

Serpin B9

SPB9_HUMAN SERPINB9

42,386

100.00%

13

15

57

Neutral amino acid transporter B(0)

AAAT_HUMAN SLC1A5

56,582

100.00%

3

3

31

SSLGPVGLDK YINENLIVNTDELGR 41.20% ADLSAMSAER AFQSLLTEVNK AQLLELPYAR GKWNEPFDETYTR GNTATQMAQALSLNTEEDIHR HLGIVDAFQQGK IEELLPGSSIDAETR INQEEQRPVQMMYQEATFK LAHVGEVR LQEDYDMESVLR LVLVNAIYFK STEVEVLLPK TEGKIEELLPGSSIDAETR WNEPFDETYTR 8.13% EVLDSFLDLAR NIFPSNLVSAAFR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

50.7 82.3 44.7 53.4 35.3 40.9 77.4 62.2 39.2 71.1 88.4 50.3 29.4 67.2 54.9 27.4 50.5 33.4 32.4 45.0 54.1 73.8 48.5 71.7 66.6 28.4 64.5 39.6 28.8 35.5 127.0 38.5 95.7 32.7 61.0 76.8 77.6 59.0 51.8 28.7 67.4 85.9 63.3 55.9 65.1 32.0 61.4 50.0 35.5 69.9 35.7

21.6 22.4 21.8 21.5 19.2 20.5 22.4 23.2 19.2 20.3 22.2 21.5 18.8 20.0 21.2 20.6 19.0 20.2 20.9 19.7 22.6 23.3 19.8 21.2 23.3 22.1 22.1 21.3 22.1 19.2 21.5 21.8 15.4 21.5 22.5 20.8 21.1 22.1 20.4 21.5 21.4 23.1 21.6 19.0 22.0 14.0 21.8 22.3 19.3 22.7 21.7

1 3 0 4 2 2 4 0 1 0 10 5 0 2 12 0 2 1 0 1 2 1 2 3 1 0 2 2 0 2 2 2 4 1 2 9 5 7 1 0 4 3 0 4 3 4 5 0 2 9 2

0 0 4 0 0 0 0 12 0 5 0 0 1 0 0 1 0 0 2 0 0 0 0 2 0 1 0 0 1 0 0 0 0 0 0 0 0 0 2 2 1 0 7 0 0 0 0 2 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,329.73 1,528.76 1,656.85 815.44 724.41 806.46 1,667.83 1,819.87 1,566.70 2,882.34 2,254.15 1,149.63 1,277.73 1,413.79 1,294.60 2,794.44 1,434.80 1,734.94 1,739.93 1,228.72 1,578.80 1,317.68 1,212.70 1,827.94 1,403.72 1,469.75 1,552.72 1,411.67 1,539.77 1,205.69 2,120.08 1,188.66 2,353.30 972.54 1,762.90 1,066.48 1,249.68 1,173.66 1,642.75 2,300.09 1,312.70 1,629.83 2,370.12 880.50 1,497.69 1,179.71 1,114.64 2,045.04 1,457.63 1,277.67 1,435.77

Table S1 page 3/159

Integrin alpha-3

ITA3_HUMAN ITGA3

118,740

100.00%

9

9

25

Glia-derived nexin

GDN_HUMAN SERPINE2

43,985

100.00%

4

4

20

Major vault protein

MVP_HUMAN MVP

99,308

100.00%

12

12

22

SELPLDPLPVPTEEGNPLLK 9.57% AAFVSEQQQK ARPVINIVHK EAGNPGSLFGYSVALHR GNSYMIQR LQSFFGGTVMGESGMK TVEDVGSPLK VYIYHSSSK YLLLAGAPR YTQVLWSGSEDQR 14.10% DMIDNLLSPDLIDGVLTR SYQVPMLAQLSVFR TIDSWMSIMVPK VLGITDMFDSSK 18.90% ALQPLEEGEDEEK DITPLQVVLPNTALHLK DLAVAGPEMQVK DQAVFPQNGLVVSSVDVQSVEPVDQR

Receptor-type tyrosine-protein phosphatase kappa

PTPRK_HUMAN PTPRK

162,085

100.00%

13

15

95

10.60%

Ras-related protein Rap-1b

RAP1B_HUMAN RAP1B

20,807

100.00%

3

3

5

16.80%

Ras-related protein Rab-11B

RB11B_HUMAN RAB11B

24,471

100.00%

5

5

20

30.30%

10 kDa heat shock protein, mitochondrial

CH10_HUMAN HSPE1

10,914

100.00%

6

7

25

60.80%

HYCTVANPVSR LAQDPFPLYPGEVLEK LFSVPDFVGDACK QAIPLDENEGIYVQDVK QMTEAIGPSTIR TAVFGFETSEAK VLFAPMR VPHNAAVQVYDYR CVTQSER ESEETIIQTDEDVPGPVPVK GLNPGTLNILVR GSGVSNFAQLIVR IAEIQAR KESEETIIQTDEDVPGPVPVK LWHLDPDTEYEIR MILTNPEGR MTSGSWTETHAVNAPTYK NGEDIPVAQTK TDQDLYR TYQGFWNPPLAPR VLLTRPGEGGTGLPGPPLITR EQGQNLAR INVNEIFYDLVR LVVLGSGGVGK AQIWDTAGQER GAVGALLVYDIAK NNLSFIETSALDSTNVEEAFK STIGVEFATR VVLIGDSGVGK GGIMLPEK GKGGEIQPVSVK KFLPLFDR SAAETVTK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

69.7 50.1 34.1 72.3 39.7 91.2 47.0 30.5 60.5 67.9 69.7 64.0 64.9 74.6 40.0 45.3 58.1 37.1 53.1 60.8 35.7 74.8 40.3 49.7 30.1 26.8 35.2 82.2 65.7 73.5 41.5 46.9 45.2 33.3 55.3 38.7 35.1 53.1 58.2 45.7 90.8 45.1 54.2 70.3 117.0 53.8 64.8 51.9 41.9 30.9 39.8

18.7 23.2 11.5 22.6 20.2 21.9 22.6 21.9 19.5 22.0 22.2 21.3 23.0 22.3 21.3 13.6 22.1 21.2 22.5 20.6 22.1 21.9 23.9 22.0 22.6 22.8 21.7 22.0 16.3 21.4 21.7 21.9 21.8 23.9 20.2 22.5 21.3 23.0 12.8 20.6 21.8 17.8 21.8 17.9 21.4 21.4 19.8 25.3 21.6 19.3 24.1

20 6 0 2 2 4 1 1 4 2 9 4 2 5 2 2 4 0 1 3 1 2 2 2 1 0 1 4 13 22 2 0 2 1 3 4 5 2 3 1 3 1 3 9 2 2 4 2 1 1 2

0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 5 8 0 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,158.17 1,135.57 1,146.71 1,774.89 984.46 1,691.78 1,044.56 1,083.55 973.58 1,568.73 2,016.03 1,654.86 1,439.69 1,328.64 1,486.69 1,872.10 1,257.65 2,812.41 1,303.62 1,815.95 1,454.70 1,930.98 1,303.67 1,286.63 849.47 1,531.77 879.40 2,182.08 1,266.75 1,347.74 800.46 2,310.17 1,686.81 1,030.54 1,996.91 1,171.60 910.43 1,546.78 2,101.21 915.46 1,494.80 985.60 1,274.61 1,289.75 2,329.12 1,080.57 1,043.61 860.46 1,198.68 1,035.60 806.43

Table S1 page 4/159

117,956

99.50%

2

2

3

2.65%

URP2_HUMAN FERMT3

75,937

100.00%

3

3

5

7.35%

VASP_HUMAN VASP

39,811

100.00%

5

6

18

12.10%

35,062

99.90%

2

2

3

8.71%

18,031

99.50%

2

2

7

25.00%

Insulin-degrading enzyme

IDE_HUMAN

Fermitin family homolog 3

Vasodilator-stimulated phosphoprotein

IDE

Electron transfer flavoprotein subunit ETFA_HUMAN ETFA alpha, mitochondrial CA123_HUMAN C1orf123 UPF0587 protein C1orf123 Podocalyxin-like protein 1

PODXL_HUMAN PODXL

58,617

100.00%

2

2

12

4.66%

Biotinidase

BTD_HUMAN BTD

61,115

100.00%

3

3

15

9.94%

VLQATVVAVGSGSK VVLDDKDYFLFR ESLDDLTNLVVK NEFIPTNFEILPLEK LEGSAPTDVLDSLTTIPELK SQDEAPGDPIQQLNLK VVLAGGVAPALFR DESANQEEPEAR QEEASGGPTAPK QVWGLNFGSK TPKDESANQEEPEAR VPAQSESVR GLLPEELTPLILATQK LEVAPISDIIAIK ATLENITNLRPVGEDFR ENSIEILSSTIKPYNAEDNENFK LASVPGSQTVVVK LGDQGPPEEAEDR LSSGLVTAALYGR QEALELMNQNLDIYEQQVMTAAQK

MA2B2_HUMAN MAN2B2

113,961

100.00%

3

3

4

Membrane-bound transcription factor MBTP1_HUMAN MBTPS1 site-1 protease DSG1_HUMAN DSG1 Desmoglein-1

117,732

99.90%

2

2

6

113,731

100.00%

6

6

52

RS19_HUMAN RPS19

16,043

99.50%

2

2

3

Poliovirus receptor-related protein 2 PVRL2_HUMAN PVRL2

57,724

100.00%

3

3

4

Epididymis-specific alphamannosidase

40S ribosomal protein S19

Protein-glutamine gammaglutamyltransferase 2

TGM2_HUMAN TGM2

77,311

100.00%

10

11

49

Bleomycin hydrolase

BLMH_HUMAN BLMH

52,545

100.00%

3

3

5

Urokinase-type plasminogen

UROK_HUMAN PLAU

48,490

100.00%

10

11

45

TSIYPFLDFMPSPQVVR 3.96% IEQEYQAGPLELNR LWWDGVASDQQK QGPISDNYLFTPGK 2.38% QRPPSGAGSVTPER VAVFDTGLSEK 8.67% EMQDLGGGER ISGVGIDQPPYGIFVINQK QEPSDSPMFIINR VGDFVATDLDTGRPSTTVR YQGTILSIDDNLQR YVMGNNPADLLAVDSR 13.10% IAGQVAAANK VLQALEGLK 7.62% MGPSFPSPKPGSER VEHESFEEPALIPVTLSVR VQVLPEVR 18.00% ALLVEPVINSYLLAER CLGIPTR DLYLENPEIK LAEKEETGMAMR LVVNFESDKLK NEFGEIQGDK TVEIPDPVEAGEEVK VVTNYNSAHDQNSNLLIEYFR YLLNLNLEPFSEK YPEGSSEER 8.13% IGPITPLEFYR LYTVEYLSNMVGGR TLYNNQPIDFLK 21.80% DKPGVYTR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

97.7 71.9 38.1 47.5 68.2 32.1 55.1 43.7 30.2 43.2 60.3 37.2 46.2 34.0 40.0 63.2 49.7 57.9 46.8 39.6 56.0 50.7 31.9 60.4 39.3 31.6 56.9 58.2 59.3 31.2 67.7 69.9 51.8 35.2 27.2 33.9 33.9 91.4 37.5 49.4 43.5 36.6 52.0 36.6 39.5 88.8 58.2 38.0 37.3 36.1 31.4

19.1 22.1 22.8 21.4 20.4 22.4 15.4 16.2 21.4 23.0 20.3 21.5 12.8 12.3 21.3 21.4 18.3 20.3 19.7 21.9 21.8 22.8 22.0 22.7 22.4 22.4 17.2 18.6 22.7 21.8 22.7 22.6 20.0 16.2 22.0 20.3 16.6 15.3 24.7 22.9 21.0 19.6 22.4 22.7 21.4 21.7 17.7 20.4 22.7 22.1 23.4

2 4 1 2 2 1 2 2 1 1 3 2 2 1 0 0 8 4 4 0 9 1 1 2 0 2 10 22 7 0 1 11 2 1 0 0 2 18 1 2 0 2 2 2 0 6 1 2 2 1 1

0 13 0 0 0 0 0 0 0 0 9 0 0 0 3 4 0 0 0 2 0 0 0 0 4 0 0 0 0 1 0 0 0 0 1 1 0 2 0 0 6 0 0 0 7 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,315.76 1,529.80 1,345.72 1,803.95 2,099.11 1,752.88 1,269.77 1,374.58 1,171.56 1,135.59 1,700.77 972.51 1,736.02 1,381.83 1,945.01 2,655.28 1,284.75 1,412.63 1,307.73 2,808.36 2,013.02 1,659.83 1,432.69 1,536.77 1,438.74 1,165.61 1,107.47 2,045.11 1,549.73 2,007.02 1,635.83 1,750.84 942.54 970.59 1,473.72 2,152.13 939.56 1,800.03 816.44 1,233.64 1,397.64 1,291.73 1,136.52 1,611.81 2,497.21 1,579.84 1,053.45 1,305.72 1,617.79 1,465.77 935.50

Table S1 page 5/159

activator

Latent-transforming growth factor beta-binding protein 1 Heterogeneous nuclear ribonucleoprotein L

LTBP1_HUMAN LTBP1

186,769

99.50%

2

2

4

HNRPL_HUMAN HNRNPL

64,115

100.00%

6

8

27

DYSADTLAHHNDIALLK EDYIVYLGR FEVENLILHK KEDYIVYLGR KPSSPPEELK LNSNTQGEMK MLCAADPQWK SDALQLGLGK VSHFLPWIR 1.57% EEPVEALTFSR TSTDLDVDVDQPKEEK 15.60% ISRPGDSDDSR NDQDTWDYTNPNLSGQGDPGSNPNKR

Golgi membrane protein 1

GOLM1_HUMAN GOLM1

45,315

100.00%

10

11

71

29.90%

Septin-2

SEPT2_HUMAN SEPT2

41,470

100.00%

6

6

25

19.70%

Peptidyl-prolyl cis-trans isomerase FKBP1A Protein disulfide-isomerase A3

FKB1A_HUMAN FKBP1A

11,933

99.50%

2

2

7

25.00%

PDIA3_HUMAN PDIA3

56,767

100.00%

32

40

439

59.60%

SDALETLGFLNHYQMK SKPGAAMVEMADGYAVDR SSSGLLEWESK TPASPVVHIR DLSENNDQR DQLVIPDGQEEEQEAAGEGR DTINLLDQR GNVLGNSK IQSSHNFQLESVNK LPQEPGR LQQDVLQFQK NIDVFNVEDQKR QQLQALSEPQPR QVEKEETNEIQVVNEEPQR ASIPFSVVGSNQLIEAK HIIDNR ILDEIEEHNIK STLINSLFLTDLYPER TIISYIDEQFER VNIVPVIAK GVQVETISPGDGR GWEEGVAQMSVGQR DASIVGFFDDSFSEAHSEFLK DGEEAGAYDGPR DLLIAYYDVDYEK DPNIVIAK EATNPPVIQEEKPK EATNPPVIQEEKPKK ELSDFISYLQR FEDKTVAYTEQK FIQENIFGICPHMTEDNKDLIQGK FISDKDASIVGFFDDSFSEAHSEFLK

FLDAGHK FLQDYFDGNLK FLQDYFDGNLKR FVMQEEFSR GFPTIYFSPANK GFPTIYFSPANKK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

32.3 48.3 36.3 54.6 55.3 69.7 37.1 86.8 32.3 40.2 72.0 42.9 79.9 61.3 29.5 62.5 41.0 40.0 103.0 59.8 30.1 88.2 38.6 42.6 45.1 58.9 40.8 74.9 30.8 45.5 51.9 66.1 36.9 61.7 107.0 36.7 66.1 88.1 45.8 80.2 42.3 64.7 45.8 43.0 28.6 31.2 71.8 58.2 53.2 61.3 65.6

22.6 21.1 20.8 22.0 21.8 22.2 19.5 22.2 19.9 23.6 22.1 20.6 17.6 22.1 21.7 23.0 20.1 18.3 21.0 23.4 24.3 22.5 18.9 22.1 23.0 22.4 21.9 19.9 20.6 22.2 20.5 22.5 10.4 21.8 21.5 20.5 14.9 22.2 16.4 21.6 20.3 22.5 22.3 21.6 20.8 21.6 22.1 22.5 18.5 22.5 21.2

0 2 4 5 10 4 1 12 0 2 2 1 0 8 0 8 0 4 6 10 1 4 8 6 1 14 0 8 1 3 4 6 3 2 5 1 17 53 4 17 1 33 0 0 0 1 9 12 38 18 4

2 0 0 0 3 0 0 0 1 0 0 2 2 3 1 0 2 0 0 0 0 11 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 6 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,896.95 1,127.57 1,241.69 1,255.67 1,111.60 1,121.53 1,235.56 1,001.56 1,154.65 1,277.64 1,818.86 1,204.56 2,890.26 1,866.91 1,867.87 1,222.60 1,076.62 1,090.48 2,169.99 1,087.58 788.43 1,630.82 796.43 1,246.68 1,476.74 1,394.74 2,298.12 1,759.96 767.42 1,352.71 1,882.00 1,513.75 952.62 1,314.67 1,533.71 2,348.07 1,236.51 1,619.78 869.51 1,579.83 1,707.93 1,370.70 1,458.71 2,863.38 2,938.38 787.41 1,359.66 1,515.76 1,188.54 1,341.68 1,469.78

Table S1 page 6/159

IFRDGEEAGAYDGPR KAQEDL KTFSHELSDFGLESTAGEIPVVAIR

LAPEYEAAATR LNFAVASR LSKDPNIVIAK MDATANDVPSPYEVR QAGPASVPLR RLAPEYEAAATR SEPIPESNDGPVK TADGIVSHLKK TEEEFKK TFSHELSDFGLESTAGEIPVVAIR

Periplakin

PEPL_HUMAN PPL

204,660

100.00%

24

24

123

14-3-3 protein gamma

1433G_HUMAN YWHAG

28,285

100.00%

11

14

101

TVAYTEQK VVVAENFDEIVNNENK YGVSGYPTLK 15.20% AGLIDWNMFVK AITGILRPPLEQGR ALEQETR ASQEEQIAR AVQDSAER EAEVLLLQQR ELDEETER ELSELIEQLQK EVDPQVNWAALVEEK FTEVYAINR GAEEQLR KVPDPVLEESFQQLQR LAALEQEEAEAR LELVEQER LLAASQAR LQNLEFALNLLR NLLDEIASR SLLGEVEQNLQAAK SSLEEESR STAEGEAFIQALPGSGTTPLLR TENPGDASDLQGR VKEEEAALAAK VLDKYEDVVQGLQK VVLQQDPQQAR 59.90% ATVVESSEK AYSEAHEISK DNLTLWTSDQQDDDGGEGNN DSTLIMQLLR LAEQAER LAEQAERYDDMAAAMK MKGDYYR NCSETQYESK NLLSVAYK NLLSVAYKNVVGAR NVTELNEPLSNEER

95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

80.0 30.2 54.3 97.0 57.6 68.8 87.5 50.8 51.7 57.8 44.4 30.7 99.2 50.9 129.0 56.8 46.3 41.9 41.8 46.8 42.8 63.7 30.6 68.0 83.2 49.2 46.5 30.5 73.8 32.0 41.2 78.8 43.9 85.9 52.6 69.8 64.2 27.8 83.5 52.6 58.0 55.2 80.8 79.3 59.4 52.0 42.7 42.2 51.4 79.1 94.6

22.5 22.9 20.3 23.5 22.6 16.6 20.8 18.9 23.2 21.9 18.8 21.9 21.5 21.9 22.6 21.9 23.4 15.1 22.4 22.2 22.0 21.1 18.3 21.7 22.4 21.9 22.0 20.5 22.9 22.4 22.2 17.6 23.6 21.5 20.6 20.4 19.6 23.5 21.4 21.2 23.5 22.8 12.8 21.3 21.6 20.8 19.2 14.3 19.1 17.7 21.6

5 1 0 24 34 5 24 4 2 10 2 1 2 5 7 33 2 2 3 4 1 6 1 9 4 8 2 0 1 1 3 2 9 19 2 10 21 0 2 8 5 6 4 113 36 4 6 2 49 4 23

12 0 10 0 0 18 0 0 1 0 1 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 2 0

0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,652.77 703.36 2,703.40 1,191.60 877.49 1,197.72 1,680.75 995.56 1,347.70 1,368.66 1,168.67 910.45 2,575.30 939.48 1,832.90 1,084.57 1,293.67 1,520.89 846.43 1,031.51 875.42 1,198.68 1,020.45 1,329.73 1,726.87 1,112.57 802.41 1,913.01 1,329.67 1,015.54 829.49 1,443.83 1,030.55 1,499.81 936.43 2,216.16 1,359.61 1,158.64 1,633.88 1,281.69 949.48 1,134.54 2,193.88 1,189.66 816.42 1,812.83 932.43 1,245.51 907.53 1,503.86 1,643.79

Table S1 page 7/159

RATVVESSEK TAFDDAIAELDTLNEDSYK VISSIEQK YDDMAAAMK YLAEVATGEK YLAEVATGEKR ARPAEVGGMQLR GNVGVVLFNFGK IFYPEIEEVQALDDTER LSEHATAPTR ALQDLENAASGDATVR EFESVLVDAFSHVAR IASLPQEVQDVSLLEK LTFLYLANDVIQNSK SVYGGEFIQQLK IGGGIDVPVPR IGQQPQQPGAPPQQDYTK IQNDAGVR SVSLTGAPESVQK VQISPDSGGLPER ELSNTAAYQSVR FASYINNDMVLQK FFPFGLVQLSSDLSK QGSIPYDSVTGPSK AAEEPSKVEEK AEDGATPSPSNETPK EAGEGGEAEAPAAEGGK GEAAAERPGEAAVASSPSK GEPAAAAAPEAGASPVEK

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

DUT_HUMAN DUT

26,689

100.00%

4

5

13

20.20%

Regulation of nuclear pre-mRNA domain-containing protein 1B

RPR1B_HUMAN RPRD1B

36,883

100.00%

5

6

14

22.70%

Far upstream element-binding protein 2

FUBP2_HUMAN KHSRP

73,129

100.00%

4

4

11

8.87%

Sialate O-acetylesterase

SIAE_HUMAN SIAE

58,297

100.00%

4

4

11

10.30%

31,536

100.00%

6

7

32

25.30%

11,350

100.00%

6

8

42

274,595

100.00%

28

28

80

51.50% DAVTYTEHAK DNIQGITKPAIR ISGLIYEETR TVTAMDVVYALK TVTAMDVVYALKR VFLENVIR 16.00% AFEDEMSGR ALVADSHPESER DASVAEAWLLGQEPYLSSR DTGNIGQER EIEELQSQAQALSQEGK EQWANLEQLSAIR EVDDLEQWIAER FESLEPEMNNQASR FMELLEPLNER HQILEQAVEDYAETVHQLSK ITDLYTDLR IVSSSDVGHDEYSTQSLVK LAEISDVWEEMK LLEVLSGER LQALDTGWNELHK

Myristoylated alanine-rich C-kinase MARCS_HUMAN MARCKS substrate

TAAKGEAAAERPGEAAVASSPSK

Histone H4

H4_HUMAN

Spectrin beta chain, brain 1

SPTB2_HUMAN SPTBN1

HIST1H4A

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

40.3 121.0 65.9 70.3 64.8 64.8 37.6 79.5 106.0 47.8 89.5 54.2 88.5 73.0 69.4 60.3 66.6 35.0 63.8 49.6 61.6 34.5 98.2 54.1 36.3 55.1 76.0 90.9 93.4 39.2 35.1 50.4 41.5 56.5 79.4 52.8 40.9 42.9 72.2 52.8 98.2 57.8 64.0 47.0 51.5 49.1 31.9 41.3 36.0 48.8 55.7

23.5 20.4 22.9 14.5 22.1 22.3 22.2 20.9 21.6 21.8 22.3 22.9 19.5 20.1 21.1 18.6 22.3 21.3 23.2 22.1 22.2 22.2 21.7 22.8 22.5 20.8 19.3 22.1 22.9 21.7 22.8 18.8 22.5 20.8 20.0 20.3 14.0 22.4 21.8 20.2 21.9 22.5 20.8 18.3 22.5 22.2 22.3 22.8 21.9 21.5 22.6

2 12 27 11 19 8 0 2 2 3 2 1 2 2 3 3 2 2 4 2 2 1 6 2 0 11 2 4 6 0 3 2 6 4 2 21 2 2 1 2 2 2 5 4 2 0 1 0 1 4 2

0 2 0 0 0 2 1 0 0 5 0 4 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 6 0 1 0 2 0 0 2 0 0 0 0 0 0 0 0 0 0 2 0 4 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,105.59 2,130.97 903.52 1,015.42 1,080.56 1,236.66 1,300.68 1,250.69 2,066.99 1,082.56 1,630.80 1,705.85 1,768.97 1,738.94 1,368.72 1,079.62 1,980.98 872.46 1,302.69 1,354.70 1,338.67 1,558.76 1,684.90 1,435.71 1,216.61 1,500.68 1,529.67 1,784.88 1,622.80 2,156.09 1,134.54 1,325.75 1,180.62 1,310.70 1,466.80 989.58 1,057.43 1,310.63 2,092.04 989.47 1,887.93 1,557.80 1,502.71 1,667.73 1,406.70 2,338.17 1,109.58 2,050.99 1,465.69 1,015.58 1,524.78

Table S1 page 8/159

Serine-threonine kinase receptorassociated protein

STRAP_HUMAN STRAP

38,421

100.00%

5

5

8

Annexin A8

ANXA8_HUMAN ANXA8

36,865

100.00%

18

22

225

LQQFLR LVSDGNINSDR LVSQDNFGFDLPAVEAATK MLTAQDMSYDEAR QALQDTLALYK SQNIVTDSSSLSAEAIR TALPAQSAATLPAR TQETPSAQMEGFLNR TQTAIASEDMPNTLTEAEK VAVVNQIAR VDSIDDR VIESTQDLGNDLAGVMALQR VLDNAIETEK VLVLSQDYGK 21.70% FSPDGELYASGSEDGTLR IYDLNKPEAEPK QGDTGDWIGTFLGHK TVDFTQDSNYLLTGGQDK YDYNSGEELESYK 66.40% AYEEDYGSSLEEDIQADTSGYLER CTQNLHSYFAER DDVSSFVDPGLALQDAQDLYAAGEK

Protein transport protein Sec23A

SC23A_HUMAN SEC23A

86,145

100.00%

3

3

12

5.62%

Destrin

DEST_HUMAN DSTN

18,488

99.50%

2

2

4

18.80%

Transmembrane protein 132A

T132A_HUMAN TMEM132A

110,089

100.00%

7

7

20

9.48%

Interstitial collagenase

MMP1_HUMAN MMP1

53,990

100.00%

13

13

96

27.10%

EGVIIEILASR FITILCTR GIGTNEQAIIDVLTK GIGTNEQAIIDVLTKR ILVCLLQGSR LIVALMYPPYR NALLSLVGSDP SATHLLR SEIDLNLIK SELSGKFER SETHGSLEEAMLTVVK SSSHFNPDPDAETLYK SWIEQEGVTVK TKNQLR TLSSMIMEDTSGDYK GPQVQQPPPSNR HLLQAPVDDAQEILHSR IDMNLTDLLGELQR HECQANGPEDLNR MIYASSK YALYDASFETK AEELVNTAPLTGVPQHVPVR EPGVTSIEVR IELTDTTLEQVR QVAGSVGGNTGVR SETFLLLQPWPR VASLEGGR VPGPAEGPAEPAAEASDEAERR ADVDHAIEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

31.1 74.3 92.1 31.2 50.6 118.0 57.0 56.3 129.0 53.0 43.6 104.0 50.6 43.0 66.2 30.0 49.8 107.0 70.8 33.7 48.5 92.5 87.1 66.6 105.0 104.0 77.7 64.5 35.3 32.1 58.1 34.5 73.3 68.7 55.7 31.5 106.0 62.3 60.0 61.3 54.6 37.6 59.8 37.1 45.4 55.1 41.4 45.4 41.4 37.9 31.3

21.2 23.2 22.1 14.3 21.4 22.8 18.8 22.0 21.4 16.0 22.5 21.9 24.2 22.0 18.7 21.7 22.6 21.7 15.1 16.5 20.8 20.9 20.8 20.8 20.6 18.3 21.2 20.6 22.9 18.7 21.7 21.8 21.7 21.8 22.5 22.7 19.3 23.7 21.5 22.3 17.7 20.3 22.6 18.0 22.7 22.8 22.4 21.5 24.3 21.6 21.0

5 3 4 2 2 4 5 1 6 3 2 2 6 4 1 1 0 2 2 1 2 6 59 11 24 4 6 20 1 1 7 2 13 5 6 1 16 8 0 2 2 1 2 0 4 4 2 2 2 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 2 4 0 0 0 0 0 0 0 0 0 0 31 3 0 0 0 0 2 0 0 0 0 4 0 0 0 0 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

804.47 1,189.58 2,022.02 1,562.65 1,263.70 1,777.89 1,367.76 1,708.80 2,065.96 969.58 819.39 2,146.08 1,131.59 1,121.62 1,900.86 1,416.74 1,631.78 2,001.94 1,596.67 2,740.18 1,525.69 2,624.24 1,199.70 1,023.57 1,571.86 1,727.97 1,158.67 1,335.75 1,085.58 797.46 1,044.59 1,052.54 1,730.86 1,807.81 1,275.66 759.45 1,693.73 1,304.67 1,942.01 1,630.85 1,539.66 815.40 1,307.62 2,127.16 1,086.58 1,417.75 1,201.63 1,486.81 788.43 2,206.04 997.50

Table S1 page 9/159

Myosin regulatory light chain 12A

ML12A_HUMAN MYL12A

19,777

100.00%

5

6

12

39.80%

ATP-dependent DNA helicase Q1

RECQ1_HUMAN RECQL

73,441

100.00%

2

2

4

3.85%

ADP-ribosylation factor 1

ARF1_HUMAN ARF1

20,680

100.00%

3

3

6

25.40%

Beta-mannosidase

MANBA_HUMAN MANBA

100,879

100.00%

13

13

46

18.30%

Low-density lipoprotein receptor

LDLR_HUMAN LDLR

95,357

100.00%

4

4

11

5.35%

Plasminogen activator inhibitor 1 RNA-binding protein

PAIRB_HUMAN SERBP1

44,948

100.00%

4

4

30

13.70%

18,630

99.50%

2

2

4

20.30%

Cold-inducible RNA-binding protein CIRBP_HUMAN CIRBP Protein S100-A9

S10A9_HUMAN S100A9

13,224

99.90%

2

2

2

18.40%

Syndecan-4

SDC4_HUMAN SDC4

21,624

100.00%

6

8

435

25.30%

AFQLWSNVTPLTFTK DIYSSFGFPR EYNLHR HIDAALSEENTGK IENYTPDLPR NSGPVVEK QMQEFFGLK SMDPGYPK SQNPVQPIGPQTPK TYFFVANK VTGKPDAETLK YDEYKR ATSNVFAMFDQSQIQEFK DGFIDKEDLHDMLASLGK FTDEEVDELYR GNFNYIEFTR LNGTDPEDVIR ISSMVVMENVGQQK VAGVVAPTLPR ILMVGLDAAGK LGEIVTTIPTIGFNVETVEYK NISFTVWDVGGQDK FASEYGYQSWPSFSTLEK FQSAVLYAAQQSK FSDNGFLMTEK GSNWIPADSFQDR GSPGLSFYFK ILFNEVTIGETDNMFNR LLLQSVVDANMNTLR TILFYPWEPTSK TVELIEEPIK VNLILEGVDTVSK VSSTEDWSFNSK VTSELLR YSFDITNVVR AHGVSSYDTVISR IYWSDLSQR NVVALDTEVASNR SEYTSLIPNLR EAGGGGVGGPGAK FDQLFDDESDPFEVLK RPDQQLQGEGK SAAQAAAQTNSNAAGK GFGFVTFENIDDAK LFVGGLSFDTNEQSLEQVFSK MSQLER NIETIINTFHQYSVK AGSGSQVPTEPK AGSGSQVPTEPKK ETEVIDPQDLLEGR ISPVEESEDVSNK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

78.7 67.5 33.6 82.8 50.8 36.8 33.9 34.2 78.8 38.3 42.5 34.7 101.0 70.1 72.9 67.0 60.9 44.7 52.0 44.1 57.3 77.2 94.2 109.0 69.9 34.3 37.8 107.0 79.6 34.2 55.9 99.4 72.5 33.9 72.1 45.0 30.3 89.7 51.8 78.6 97.2 55.5 91.7 55.2 123.0 35.5 47.7 77.2 39.5 89.2 101.0

20.1 21.3 21.0 22.5 23.0 21.0 21.0 18.5 21.8 23.1 23.4 19.6 21.5 22.1 19.4 21.7 22.8 22.9 14.8 23.1 18.5 23.3 21.2 22.1 19.5 21.0 23.1 22.1 21.0 23.1 20.8 19.5 20.1 22.3 21.4 23.3 22.4 22.1 23.0 21.0 20.3 22.1 22.9 21.5 22.0 24.1 21.5 22.3 22.0 22.5 22.0

9 18 2 15 7 1 4 1 26 5 5 2 4 2 2 2 1 1 3 2 2 2 3 6 3 1 3 3 7 1 5 5 4 1 4 1 1 3 6 4 8 8 10 2 2 1 1 99 3 134 33

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,752.93 1,188.57 831.41 1,384.67 1,217.62 829.44 1,127.56 910.40 1,490.80 989.51 1,158.64 873.41 2,090.99 2,003.98 1,415.63 1,260.60 1,228.62 1,581.76 1,079.66 1,087.62 2,323.24 1,565.76 2,126.97 1,440.75 1,288.59 1,492.68 1,102.56 2,028.97 1,702.92 1,481.77 1,170.66 1,386.78 1,386.62 817.48 1,213.62 1,391.69 1,167.58 1,387.72 1,292.69 1,013.50 1,943.89 1,255.64 1,460.71 1,559.74 2,345.17 763.38 1,806.94 1,157.58 1,285.68 1,613.80 1,432.68

Table S1 page 10/159

Protein transport protein Sec24C

SC24C_HUMAN SEC24C

118,307

100.00%

2

2

2

Transketolase

TKT_HUMAN TKT

67,861

100.00%

29

39

526

KLEENEVIPK RISPVEESEDVSNK 3.02% AVITSLLDQIPEMFADTR TLFQPQTGAYQTLAK 50.70% AFDQIR AVELAANTK AYGQALAK DAIAQAVR HQPTAIIAK IIALDGDTK ILATPPQEDAPSVDIANIR ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR

ISSDLDGHPVPK KAYGQALAK KILATPPQEDAPSVDIANIR KISSDLDGHPVPK KLILDSAR LDNLVAILDINR LGHASDR LGQSDPAPLQHQMDIYQK LQALKDTANR MFGIDRDAIAQAVR MPSLPSYK NMAEQIIQEIYSQIQSK NSTFSEIFK NSTFSEIFKK QAFTDVATGSLGQGLGAACGMAYTGK

Splicing factor, arginine/serine-rich 9 SFRS9_HUMAN SFRS9

25,525

100.00%

4

5

9

Cathepsin S

CATS_HUMAN CTSS

37,478

99.50%

2

2

4

Integrin alpha-6

ITA6_HUMAN ITGA6

126,618

100.00%

8

8

36

SGKPAELLK SVPTSTVFYPSDGVATEK TSRPENAIIYNNNEDFQVGQAK TVPFCSTFAAFFTR VLDPFTIKPLDR VLDPFTIKPLDRK 21.30% DGVGMVEYLR EKDLEDLFYK IYVGNLPTDVR VLVSGLPPSGSWQDLK 6.04% GIDSDASYPYK ILPDSVDWR 9.91% LETTSNQDNLAPITAK LIATFPDTLTYSAYR LLLVGAPR LNYLDILMR NIGDINQDGYPDIAVGAPYDDLGK

Prostaglandin F2 receptor negative regulator

FPRP_HUMAN PTGFRN

98,538

100.00%

15

15

47

SEDEVGSLIEYEFR SRPVINIQK VNSLPEVLPILNSDEPK 17.50% ALSADQGSYR AQDGDFIFSK EGEPFELR EHTDTFNFR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

57.7 78.5 55.9 35.7 35.9 55.9 42.9 37.0 37.1 49.7 99.8 86.0 55.6 51.4 54.1 83.2 53.6 86.8 31.3 76.0 38.6 57.1 43.0 113.0 38.8 44.5 91.2 46.1 94.8 84.7 64.8 62.8 27.9 57.9 60.4 50.9 50.8 45.5 30.5 82.8 73.0 34.5 73.7 90.2 66.7 34.9 56.5 62.2 40.9 36.5 35.3

21.6 23.1 21.6 20.7 25.6 23.0 22.7 22.7 17.4 23.1 20.1 18.9 22.7 20.5 17.8 20.7 19.8 17.6 21.3 22.1 21.6 22.8 21.8 21.7 20.6 22.6 21.0 19.6 22.3 21.6 22.1 19.2 14.9 22.6 21.9 22.0 20.0 20.9 23.5 21.9 21.5 12.6 21.7 21.5 21.0 16.1 19.6 22.1 21.4 22.3 20.3

78 33 1 1 8 4 3 1 3 10 68 0 9 3 0 3 7 21 1 8 1 2 5 28 2 7 4 1 60 6 6 20 0 1 3 2 2 2 2 3 8 1 9 2 2 3 8 2 4 1 1

29 26 0 0 0 0 0 0 0 0 30 2 11 0 2 4 0 0 0 11 0 11 0 57 0 0 2 0 0 71 0 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,198.67 1,588.78 2,036.04 1,666.88 749.39 916.51 821.45 843.47 978.57 945.53 2,020.07 3,752.91 1,264.65 949.55 2,148.17 1,392.75 915.56 1,368.79 755.38 2,069.01 1,129.63 1,562.81 938.47 2,039.01 1,072.53 1,200.63 2,532.19 942.56 1,884.92 2,508.21 1,651.79 1,413.81 1,541.91 1,138.56 1,299.65 1,246.68 1,682.91 1,215.55 1,100.57 1,715.88 1,731.90 838.55 1,150.63 2,520.19 1,672.77 1,054.64 1,864.01 1,067.51 1,127.54 976.47 1,166.52

Table S1 page 11/159

26,580

100.00%

6

8

31

CNDP2_HUMAN CNDP2

52,862

100.00%

12

14

40

Aspartate aminotransferase, cytoplasmic

AATC_HUMAN GOT1

46,230

100.00%

14

17

85

Ubiquitin-like modifier-activating enzyme 1

UBA1_HUMAN UBA1

117,832

100.00%

20

24

171

Eukaryotic translation initiation factor 6

IF6_HUMAN

Cytosolic non-specific dipeptidase

EIF6

GEILLR LDTVGSDAYR MDVLNAFK MPDSTLPGSR MYQTQVSDAGLYR NVQPSDQGHYK SDLSLER TANDAVELHIK VLADSLHVGPSARPPPSLSLR VPTATLVR YIISLDQDSVVK 37.10% ASFENNCEIGCFAK ETEEILADVLK HGLLVPNNTTDQELQHIR LNEAQPSTIATSMR NSLPDTVQIR TSIEDQDELSSLLQVPLVAGTVNR

38.10% EGGSIPVTLTFQEATGK GNILIPGINEAVAAVTEEEHK GSTDDKGPVAGWINALEAYQK LPDGSEIPLPPILLGR LVPNMTPEVVGEQVTSYLTK NVMLLPVGSADDGAHSQNEK QKLPDGSEIPLPPILLGR QLGGSVELVDIGK TVFGVEPDLTR WVAIQSVSAWPEK YIDENQDR YPSLSLHGIEGAFSGSGAK 42.90% APPSVFAEVPQAQPVLVFK EPESILQVLSQMEK HIYLLPSGR IANDNSLNHEYLPILGLAEFR IGADFLAR INVSGLTTK ITWSNPPAQGAR IVASTLSNPELFEEWTGNVK KVNLGVGAYR LALGDDSPALK NFGLYNER NLDYVATSIHEAVTK QIASVMK VGGVQSLGGTGALR 26.50% AAVATFLQSVQVPEFTPK AENYDIPSADR AEVSQPR ALPAVQQNNLDEDLIR ALPAVQQNNLDEDLIRK ATLPSPDKLPGFK GNVQVVIPFLTESYSSSQDPPEK IYDDDFFQNLDGVANALDNVDAR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

32.3 62.8 50.7 56.4 102.0 32.8 46.8 33.1 51.5 36.9 44.7 52.3 59.7 67.8 72.1 35.5 73.3 83.1 45.9 29.3 56.4 81.5 90.0 47.3 87.9 48.0 77.1 42.8 36.4 87.1 73.5 33.6 29.8 65.7 35.8 68.0 102.0 33.9 47.6 30.6 83.2 32.1 76.6 73.1 44.4 31.7 95.9 50.8 31.8 75.7 53.6

22.0 21.7 22.8 21.8 20.6 20.9 24.7 22.4 15.4 18.9 22.1 15.8 22.1 20.6 23.1 22.4 19.0 22.7 20.9 22.4 13.4 21.5 21.8 13.0 22.4 22.9 22.7 20.1 21.7 17.8 22.2 18.8 20.8 24.4 20.4 22.3 21.2 17.9 21.9 21.4 21.4 22.6 22.2 19.3 21.2 20.5 22.0 19.2 20.1 21.8 19.7

1 8 2 9 5 1 4 0 0 3 2 2 2 0 6 1 8 4 2 0 4 4 3 3 3 4 2 1 0 10 14 2 0 9 3 10 9 0 4 1 4 1 6 20 3 2 6 1 1 4 4

0 0 0 0 0 0 0 2 2 0 0 0 0 3 0 0 7 0 0 1 0 0 3 5 0 0 0 0 1 3 0 0 5 0 0 0 1 1 0 0 2 0 0 2 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

700.44 1,096.53 937.48 1,060.51 1,531.72 1,272.60 819.42 1,210.64 2,169.21 856.53 1,379.74 1,646.69 1,259.67 2,085.08 1,534.75 1,142.62 2,584.35 1,734.89 2,204.16 2,220.09 1,686.98 2,221.14 2,097.99 1,943.13 1,314.73 1,233.65 1,500.79 1,052.47 1,877.94 2,024.12 1,630.84 1,055.60 2,399.24 862.48 932.54 1,297.67 2,234.13 1,076.62 1,099.60 1,012.49 1,660.85 792.43 1,271.71 1,933.04 1,250.57 786.41 1,808.95 1,937.05 1,370.77 2,521.25 2,600.19

Table S1 page 12/159

LAGTQPLEVLEAVQR LAYVAAGDLAPINAFIGGLAAQEVMK

Proteasome subunit beta type-5

PSB5_HUMAN PSMB5

28,463

100.00%

9

12

69

Golgi apparatus protein 1

GSLG1_HUMAN GLG1

134,536

100.00%

3

3

5

Coactosin-like protein

COTL1_HUMAN COTL1

15,927

100.00%

11

12

40

Aspartate aminotransferase, mitochondrial

AATM_HUMAN GOT2

47,459

100.00%

11

12

78

LDQPMTEIVSR LKSDTAAAAVR LQTSSVLVSGLR LVVADTR NEEDAAELVALAQAVNAR NFPNAIEHTLQWAR QPAENVNQYLTDPK SLVASLAEPDFVVTDFAK VGPDTER YDGQVAVFGSDLQEK 31.20% ATAGAYIASQTVK ATAGAYIASQTVKK DAYSGGAVNLYHVR GPGLYYVDSEGNR HGVIVAADSR ISVAAASK LLANMVYQYK RGPGLYYVDSEGNR VSSDNVADLHEK 2.97% FCENTQAGEGR IIIQESALDYR VAELSSDDFHLDR 70.40% AGGANYDAQTE ELEEDFIK ELEEDFIKSELK EVVQNFAK FALITWIGENVSGLQR FTTGDAMSK FTTGDAMSKR KAGGANYDAQTE LFAFVR TGTDKTLVK YDGSTIVPGEQGAEYQHFIQQCTDDVR

28.80% ASAELALGENSEVLK DAGMQLQGYR EIATVVK FVTVQTISGTGALR IAAAILNTPDLR IAAAILNTPDLRK IGASFLQR ISVAGVTSSNVGYLAHAIHQVTK

Nascent polypeptide-associated complex subunit alpha

NACA_HUMAN NACA

23,365

100.00%

6

6

44

MNLGVGAYR NLDKEYLPIGGLAEFCK NMGLYGER 30.70% IEDLSQQAQLAAAEK NILFVITKPDVYK NNSNDIVNAIMELTM QVTGVTR SKNILFVITKPDVYK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

92.1 42.4 61.0 63.2 81.7 35.2 110.0 55.8 76.0 93.3 53.2 97.5 110.0 83.7 72.1 71.3 56.1 34.9 67.5 67.8 84.0 49.2 66.4 36.9 52.1 38.4 58.2 33.7 81.7 39.2 46.6 36.2 34.8 41.8 39.1 59.8 76.5 40.3 107.0 74.9 49.8 70.4 24.3 34.1 30.4 46.1 128.0 77.0 40.6 35.5 40.7

17.9 18.7 23.5 21.1 19.1 24.6 21.8 22.3 22.6 22.0 20.1 21.6 21.0 19.3 23.2 21.4 21.2 22.4 21.2 22.4 22.5 17.0 22.0 21.0 17.0 22.8 22.8 23.4 20.8 17.2 21.6 20.1 16.3 19.1 17.3 22.6 21.2 22.8 20.9 18.0 15.9 21.7 17.8 23.3 22.0 20.5 22.3 15.8 20.3 24.2 13.4

23 0 12 4 10 1 14 1 8 19 3 7 13 2 7 4 17 1 9 2 8 1 2 0 2 3 2 2 14 2 2 1 8 1 0 8 10 2 35 8 3 4 0 1 0 4 14 10 3 1 0

9 4 0 4 0 0 9 0 0 0 0 0 0 0 2 0 0 0 0 1 3 0 0 2 0 0 0 0 1 0 0 0 0 0 2 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,623.91 2,619.39 1,304.65 1,102.62 1,259.73 773.45 1,883.95 1,696.86 1,616.79 1,909.00 773.38 1,655.79 1,280.69 1,408.78 1,521.75 1,426.66 1,024.55 746.44 1,242.66 1,582.76 1,313.63 1,268.53 1,320.72 1,503.71 1,096.45 1,022.50 1,479.76 934.50 1,803.98 973.43 1,113.54 1,224.55 752.45 962.55 3,113.39 1,530.80 1,138.53 759.46 1,449.81 1,267.74 1,395.83 891.51 2,352.27 980.50 1,967.00 955.43 1,614.83 1,549.90 1,710.77 760.43 1,765.03

Table S1 page 13/159

Coatomer subunit beta'

COPB2_HUMAN COPB2

102,471

100.00%

3

3

10

G-protein coupled receptor 126

GP126_HUMAN GPR126

136,681

99.50%

2

2

19

Prefoldin subunit 2

PFD2_HUMAN PFDN2

16,630

99.50%

2

2

3

26S proteasome non-ATPase regulatory subunit 7 Poly(ADP-ribose) glycohydrolase ARH3

PSD7_HUMAN PSMD7

37,008

99.50%

2

2

4

ARHL2_HUMAN ADPRHL2

38,929

100.00%

3

3

8

MAT2B_HUMAN MAT2B

37,534

100.00%

6

7

20

Methionine adenosyltransferase 2 subunit beta

SPASDTYIVFGEAK 4.53% AAESLADPTEYENLFPGLK LPEAAFLAR NVMEEGKDFQPSR 2.46% LLLGSNQNEIVSLK VILPQTSDAYQVSVAK 16.90% GAVSAEQVIAGFNR IIETLTQQLQAK 7.72% DIKDTTVGTLSQR SVVALHNLINNK 10.70% ALVQSLLAK HVQSLEPDPGTPGSER TEALYYTDDTAMAR 24.30% AVLENNLGAAVLR IPILYGEVEK LETLGIGQR LVEEEVNIPNRR RPDVVENQPDAASQLNVDASGNLAK

VLVTGATGLLGR Brain acid soluble protein 1

BASP1_HUMAN BASP1

22,675

100.00%

6

7

20

50.70%

AAEAAAAPAESAAPAAGEEPSKEEGEPK

AEPPKAPEQEQAAPGPAAGGEAPK

ESEPQAAAEPAEAK ETPAATEAPSSTPK KTEAPAAPAAQETK SDGAPASDSKPGSSEAAPSSK Calcyclin-binding protein

CYBP_HUMAN CACYBP

26,192

100.00%

2

2

2

Proteasome subunit alpha type-6

PSA6_HUMAN PSMA6

27,382

100.00%

8

10

75

26S proteasome non-ATPase regulatory subunit 2

PSMD2_HUMAN PSMD2

100,184

100.00%

6

6

14

Lactadherin

MFGM_HUMAN MFGE8

43,105

100.00%

3

3

6

Myotrophin

MTPN_HUMAN MTPN

12,877

100.00%

2

2

4

Probable ATP-dependent RNA helicase DDX6 Ubiquitin thioesterase OTUB1

DDX6_HUMAN DDX6

54,401

99.50%

2

2

6

OTUB1_HUMAN OTUB1

31,267

100.00%

5

5

13

19.30% KAELLDNEKPAAVVAPITTGYTVK SYSMIVNNLLKPISVEGSSK 37.40% AINQGGLTSVAVR GSSAGFDR HITIFSPEGR ILTEAEIDAHLVALAERD LLDSSTVTHLFK LYQVEYAFK QTESTSFLEK YGYEIPVDMLCK 9.69% APVQPQQSPAAAPGGTDEKPSGK AVPLALALISVSNPR EDVLTLLLPVMGDSK FGGSGSQVDSAR HLAGEVAK VGQAVDVVGQAGKPK 10.90% EVTGIITQGAR MWVTGVVTQGASR NAVHVNLFETPVEAQYVR 25.40% GPDGLTAFEATDNQAIK NGDLDEVKDYVAK 7.25% GPVKPTGGPGGGGTQTQQQMNQLK SGAYLIPLLER 23.60% EYAEDDNIYQQK FFEHFIEGGR GEGGTTNPHIFPEGSEPK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

107.0 78.6 64.0 37.0 87.7 71.2 68.6 43.9 50.7 62.6 56.7 52.2 83.8 90.4 36.8 65.2 42.4 64.6 85.1 35.6 46.4 54.5 41.3 66.8 50.1 33.1 28.3 96.8 46.3 60.8 123.0 73.4 54.5 45.3 50.6 56.1 33.1 63.4 79.8 37.7 84.5 83.5 46.0 27.4 103.0 49.4 64.6 40.5 68.4 41.0 38.3

22.5 22.0 22.5 20.9 17.9 20.5 22.9 18.5 22.1 18.9 15.3 23.4 18.9 19.1 21.0 22.0 21.0 22.0 16.0 20.5 21.8 20.0 21.7 21.7 21.2 14.9 20.1 20.8 18.3 21.5 20.1 21.6 23.7 22.4 20.6 21.6 12.0 20.9 21.6 18.9 18.1 23.1 22.5 21.5 22.9 22.7 22.0 19.2 18.7 22.3 21.5

14 6 3 1 8 11 2 1 2 2 4 2 2 3 1 4 2 0 6 0 0 4 4 3 3 0 0 20 2 12 6 10 10 4 4 0 0 3 2 1 3 4 1 0 2 2 0 2 4 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 2 2 0 0 0 2 1 1 0 0 0 2 5 0 0 0 4 1 0 0 0 0 0 0 1 0 0 4 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,484.73 2,065.01 987.56 1,552.71 1,527.87 1,718.93 1,418.74 1,385.80 1,433.76 1,321.76 942.60 1,705.81 1,636.72 1,339.77 1,160.66 986.56 1,467.79 2,608.30 1,156.71 2,636.23 2,298.14 1,427.67 1,386.68 1,412.74 1,932.88 2,528.40 2,182.14 1,285.72 796.36 1,156.61 1,979.05 1,360.75 1,160.60 1,169.57 1,503.69 2,218.11 1,520.92 1,629.88 1,167.54 824.46 1,452.82 1,144.63 1,407.71 2,086.07 1,747.85 1,465.72 2,382.18 1,231.71 1,515.66 1,238.60 1,853.87

Table S1 page 14/159

Integrin beta-4

ITB4_HUMAN ITGB4

202,133

100.00%

9

9

38

60S ribosomal protein L10a

RL10A_HUMAN RPL10A

24,814

100.00%

8

11

26

Clusterin

CLUS_HUMAN CLU

52,477

100.00%

14

17

904

ATP-citrate synthase

ACLY_HUMAN ACLY

120,825

100.00%

13

13

23

75,373

99.90%

2

2

4

52,145

100.00%

3

3

14

IQQEIAVQNPLVSER LLTSGYLQR 5.98% DVVSFEQPEFSVSR EAIINLATQPK LLELQEVDSLLR LVFSALGPTSLR MLLIENLR NVISLTEDVDEFR QEVEENLNEVYR TQDYPSVPTLVR VAPGYYTLTADQDAR 27.60% AGKFPSLLTHNENMVAK AVDIPHMDIEALK AVDIPHMDIEALKK DTLYEAVR FPSLLTHNENMVAK KYDAFLASESLIK STMGKPQR YDAFLASESLIK 30.30% ALQEYR ASSIIDELFQDR ELDESLQVAER FMETVAEK IDSLLENDR KTLLSNLEEAK KYNELLK LFDSDPITVTVPVEVSR QQTHMLDVMQDHFSR RPHFFFPK SGSGLVGR TLLSNLEEAK TLLSNLEEAKK VTTVASHTSDSDVPSGVTEVVVK

N-acetylgalactosaminyltransferase 7 GALT7_HUMAN GALNT7 Ras GTPase-activating proteinbinding protein 1

G3BP1_HUMAN G3BP1

15.10% AFDSGIIPMEFVNK DLVSSLTSGLLTIGDR EAYPEEAYIADLDAK FICTTSAIQNR IGNTGGMLDNILASK LGQEATVGK LYRPGSVAYVSR QHFPATPLLDYALEVEK SGGMSNELNNIISR SINNPDMR TIAIIAEGIPEALTR TILSLMTR WGDIEFPPPFGR 5.02% LEGWQGNPPPIYVGSSPTLK SPAMAGGLFAIER 9.87% EAGEQGDIEPR LPNFGFVVFDDSEPVQK SSSPAPADIAQTVQEDLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

108.0 44.2 62.7 72.8 70.7 46.1 37.7 40.6 64.9 31.8 110.0 36.3 27.0 42.4 52.1 49.5 70.5 30.7 72.0 45.8 105.0 65.7 57.8 53.6 47.9 43.6 102.0 43.0 35.2 85.3 71.8 52.6 84.9 47.2 58.7 59.5 39.8 90.9 54.2 28.5 27.2 58.6 39.1 73.2 34.4 30.4 67.1 73.2 42.3 80.2 92.7

20.4 19.2 22.3 19.4 20.4 18.1 22.8 22.3 22.1 22.2 22.6 20.8 22.6 20.7 22.5 22.9 21.2 24.1 21.5 24.6 23.5 22.5 19.0 22.9 20.4 19.1 21.7 19.9 23.9 23.2 23.1 20.4 21.6 23.0 20.8 21.0 22.8 22.1 23.9 20.7 21.2 21.5 20.6 17.0 21.4 22.5 20.9 23.0 20.8 22.1 22.0

4 2 4 9 4 4 5 2 2 3 5 0 0 2 6 2 3 1 2 2 188 242 83 26 3 28 88 0 0 21 30 11 34 2 2 1 1 4 2 0 0 2 1 3 1 1 2 2 3 6 5

0 0 0 0 0 0 0 0 0 0 0 2 1 1 0 0 5 0 0 0 0 0 0 0 1 0 0 9 57 0 0 0 64 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,723.93 1,050.59 1,625.78 1,197.68 1,427.81 1,260.73 1,001.58 1,536.75 1,521.72 1,375.72 1,640.79 1,856.97 1,451.76 1,595.85 966.49 1,616.81 1,484.80 904.47 1,356.71 779.41 1,393.70 1,288.64 970.46 1,074.54 1,245.71 907.53 1,873.99 1,872.85 1,075.58 732.40 1,117.61 1,245.71 2,314.18 1,567.78 1,646.90 1,697.79 1,310.65 1,503.78 902.49 1,367.74 1,971.02 1,507.72 962.44 1,567.91 934.54 1,417.69 2,140.11 1,335.67 1,200.55 1,937.97 1,884.93

Table S1 page 15/159

U1 small nuclear ribonucleoprotein A

SNRPA_HUMAN SNRPA

Dipeptidyl peptidase 1

CATC_HUMAN CTSC

51,824

100.00%

2

3

8

Dynactin subunit 2

DCTN2_HUMAN DCTN2

44,214

100.00%

4

4

7

Transferrin receptor protein 1

TFR1_HUMAN TFRC

84,856

100.00%

11

12

42

Involucrin

INVO_HUMAN IVL

68,457

100.00%

5

5

7

Glucosidase 2 subunit beta

GLU2B_HUMAN PRKCSH

59,408

100.00%

17

19

142

31,262

100.00%

4

4

10

17.00%

AVQGGGATPVVGAVQGPVPGMPPMTQAPR

EVSSATNALR GQAFVIFK KAVQGGGATPVVGAVQGPVPGMPPMTQAPR

4.10% AINAIQK NVHGINFVSPVR 12.70% ASVEDADTQSK LLGPDAAINLTDPDGALAK VAELEKR WSPIASTLPELVQR 17.00% AAAEVAGQFVIK DSAQNSVIIVDK GFVEPDHYVVVGAQR ILNIFGVIK LAQMFSDMVLK LLNENSYVPR SGVGTALLLK SSGLPNIPVQTISR VEYHFLSPYVSPK VSASPLLYTLIEK YNSQLLSFVR 12.00% HLEEQEGQLK HLEQQQGQLEVPEQQVGQPK HLVQQEGQLEQQER QEAQLELPEQQVGQPK YLEQQEGQLK 32.20% AQQEQELAADAFK ERESLQQMAEVTR ESLQQMAEVTR ETMVTSTTEPSR ILIEDWK ILIEDWKK LGGSPTSLGTWGSWIGPDHDK LGGSPTSLGTWGSWIGPDHDKFSAMK

Ras-related protein Rab-1A

RAB1A_HUMAN RAB1A

22,660

100.00%

5

5

15

Heterogeneous nuclear ribonucleoprotein K

HNRPK_HUMAN HNRNPK

50,961

100.00%

9

11

68

LIELQAGKK LVSQKPK LWEEQLAAAK NKFEEAER SEALPTDLPAPSAPDLTEPK SLEDQVEMLR SLKDMEESIR TVKEEAEKPER YEQGTGCWQGPNR 36.10% EFADSLGIPFLETSAK IQSTPVK LLLIGDSGVGK LQIWDTAGQER MGPGATAGGAEK NATNVEQSFMTMAAEIK 26.30% ENTQTTIK GSYGDLGGPIITTQVTIPK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

36.5 56.3 38.9 44.3 42.1 49.5 69.6 90.6 51.5 80.7 53.7 67.3 69.6 51.1 43.2 77.2 43.9 55.0 30.7 102.0 62.3 41.5 33.8 29.3 63.9 34.1 93.1 27.0 62.1 72.4 32.9 31.3 51.2 23.8 33.5 36.2 61.3 34.1 82.2 74.8 56.1 46.2 70.4 77.3 31.5 58.7 61.5 55.5 103.0 31.6 97.7

21.2 23.1 20.3 20.2 21.8 20.3 20.5 20.0 23.7 19.2 21.3 23.4 22.7 12.3 21.6 23.9 17.6 19.4 22.2 17.0 21.7 22.9 21.5 21.9 22.9 22.9 23.1 22.6 22.8 21.1 24.2 21.0 21.7 21.0 18.3 18.6 23.7 21.8 21.6 22.8 22.7 23.0 18.0 23.1 20.7 20.3 22.2 20.3 20.3 23.3 19.2

0 4 3 0 4 2 2 2 1 2 4 2 1 7 2 2 3 6 0 9 3 2 0 0 1 1 11 0 10 35 1 1 0 0 2 2 11 2 4 10 2 7 2 7 2 2 7 2 2 1 5

2 0 0 1 0 2 0 0 0 0 0 0 2 0 0 0 0 0 1 0 0 0 1 2 0 0 0 1 0 0 0 0 2 0 0 0 0 0 0 0 6 32 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,759.40 1,047.54 909.52 2,887.49 757.46 1,338.73 1,150.52 1,865.00 844.49 1,596.88 1,203.67 1,288.68 1,672.84 1,016.65 1,314.64 1,204.63 958.59 1,468.81 1,565.80 1,433.83 1,226.65 1,210.61 2,300.16 1,721.86 1,821.94 1,235.63 1,448.70 1,576.78 1,291.63 1,354.62 916.51 1,044.61 2,168.04 2,748.31 999.62 799.50 1,158.62 1,022.49 2,049.04 1,219.60 1,207.60 1,315.69 1,552.66 1,724.87 772.46 1,071.64 1,316.66 1,062.49 1,916.87 934.48 1,917.03

Table S1 page 16/159

Collagen alpha-1(XII) chain

COCA1_HUMAN COL12A1

333,127

100.00%

56

58

484

IDEPLEGSEDR IILDLISESPIK IITITGTQDQIQNAQYLLQNSVK NAGAVIGK RPAEDMEEEQAFKR TDYNASVSVPDSSGPER VVLIGGKPDR 24.50% ALALGALQNIR DITDTSIGAYWTSAPGMVR DYKPQVGVIADPSSK FNQMLNQIPNDYQSSR GDTTNTVLQGLK GEVQTVTFDTEEVK GGNTLTGMALNFIR GGNTMTGDAIDYLVK GMTSSEPISIMEK GPGDLEAPSNLVISER GQEITVR IEQELAAIK IIYRPVAGGESR IIYSPTVGDPIDEYTTVPGR ITEVTSEGFR ITVDPTTDGPTK ITWTQAPGR ITYQPSTGEGNEQTTTIGGR IVEVFDIGPK LGELVVGPYDNTVVLEELR LKPDTPYTITVSSLYPDGEGGR LLPETPSDPFAIWQITDR LNWNPSPSPVTGYK LQPQTTYDITVLPIYK LSPADGTR MIATDPDDTHAYNVADFESLSR NLQPDTSYTVTVVPVYTEGDGGR

NNVILQPLQPDTPYK NSDVEIFAVGVK NTFTESAGAR NVGVEVFSLGIK NVQVYNPTPNSLDVR QHALSVGPQTTTLSVR QVCEQLISGQMNR SLLQAVANLPYK SLYDDVDTGEK SQDDVEAPSKK SQDEVEIPAR TEFNLNQYYQR TLENLIPDTK TLKVDEETENTMR TSDPTMSSFR VEDIIEAINTFPYR VGVVQYSSDTR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

78.2 99.9 59.6 34.0 52.2 81.8 33.2 91.3 45.6 50.1 92.1 57.4 96.3 46.7 89.9 76.9 87.6 30.5 47.8 32.6 65.1 72.8 41.6 32.9 124.0 62.0 75.2 37.6 36.0 62.1 69.4 34.2 55.0 79.1 62.1 66.7 40.7 62.3 50.6 31.9 63.1 68.4 39.5 44.4 60.3 48.3 38.4 40.5 32.2 62.9 88.7

19.5 14.9 17.2 23.3 21.5 19.4 12.6 11.1 21.8 22.6 20.5 22.9 22.9 22.1 22.6 20.5 22.5 25.5 20.4 21.7 21.7 23.2 23.4 22.0 21.1 21.3 20.2 21.3 21.2 23.0 17.7 21.6 18.1 21.3 21.0 22.7 22.5 20.6 22.0 20.2 22.4 18.3 21.3 22.8 21.4 21.3 23.6 22.0 19.7 22.3 23.1

2 36 1 2 0 8 2 24 2 2 7 14 12 2 20 12 25 1 2 1 4 14 6 2 17 28 6 0 4 10 20 2 0 6 4 3 6 20 2 0 2 37 6 1 16 4 2 2 1 11 31

0 0 7 0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 6 0 0 0 0 3 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 6 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,259.58 1,340.80 2,589.39 729.43 1,751.80 1,780.80 1,053.64 1,139.69 2,056.97 1,603.83 1,954.91 1,246.66 1,581.77 1,464.76 1,570.74 1,441.66 1,653.85 802.44 1,014.58 1,317.73 2,193.11 1,138.57 1,244.64 1,029.55 2,110.01 1,116.63 2,115.13 2,366.19 2,099.08 1,559.79 1,893.04 816.42 2,484.10 2,468.19 1,739.93 1,277.67 1,053.50 1,261.72 1,715.87 1,694.92 1,562.74 1,316.76 1,241.55 1,203.59 1,143.56 1,475.69 1,143.63 1,581.74 1,144.49 1,679.86 1,210.61

Table S1 page 17/159

Dipeptidyl peptidase 3

DPP3_HUMAN DPP3

82,574

100.00%

12

14

69

VILTPMTAGSR VLVVVTDGR VPPTVTSTVLK VQIALAQYSGDPR VSDPTTSTMK VSWDPSPSPVLGYK VSWTPPSDSVDR VTDETTDSFK VTWEPAPGEVK VVYSPVDGTRPSESIVVPGNTR VYDPSTSTLNVR WDPAPGPVLQYR 23.50% AQDPDQLR EVDGEGKPYYEVR FPEDGPELEEILTQLATADAR FSTIASSYEECR GEFEGFVAVVNK LAQDFLDSQNLSAYNTR LASVLGSEPSLDSEVTSK NVSLGNVLAVAYATQR SGETWDSK VILGSEAAQQHPEEVR VLLEAGEGLVTITPTTGSDGRPDAR

Branched-chain-amino-acid aminotransferase, mitochondrial

BCAT2_HUMAN BCAT2

44,270

100.00%

6

6

14

Keratinocyte proline-rich protein

KPRP_HUMAN KPRP

64,115

100.00%

4

4

48

Granulins

GRN_HUMAN GRN

63,522

100.00%

16

20

423

Prostasin

PRSS8_HUMAN PRSS8

36,413

99.50%

2

2

4

VVEQLEK 21.20% AADLQLEMTQKPHK KPGPGEPLVFGK LFRPWLNMDR LGGNYGPTVLVQQEALK NLHIPTMENGPELILR QSLLDMAQTWGEFR 6.74% GRPAVCQPQGR IEISSPCCPR LQLFPR RLDQCPESPLQR 26.30% APAHLSLPDPQALK APAHLSLPDPQALKR ASLSHPR AVALSSSVMCPDAR CITPTGTHPLAK EVVSAQPATFLAR GSEIVAGLEK LPAHTVGDVK QGVCCADR QGWACCPYR QHCCPAGYTCNVK SCEKEVVSAQPATFLAR SPHVGVK VHCCPHGAFCDLVHTR WDAPLRDPALR WPTTLSR 6.12% LGAHQLDSYSEDAK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

33.3 58.0 34.9 82.7 49.5 69.6 33.0 64.2 33.2 42.5 80.8 53.7 34.1 51.4 33.3 69.1 48.4 125.0 65.7 117.0 60.8 90.8 70.2 40.9 37.5 43.7 26.9 70.2 42.6 88.7 41.6 37.3 35.0 52.8 57.7 64.5 58.1 81.5 58.6 87.5 66.4 53.1 46.8 44.3 51.9 43.4 39.2 20.5 28.9 32.6 36.3

22.7 20.0 18.1 22.5 21.6 23.2 21.2 20.0 21.3 20.4 22.6 22.0 20.5 22.7 21.5 18.4 22.1 21.5 22.7 20.0 20.0 21.7 19.8 20.9 22.2 19.2 23.5 19.5 21.2 21.8 22.6 20.1 23.2 21.6 20.4 18.8 20.6 21.7 21.7 22.3 22.8 20.0 14.9 15.8 15.8 22.0 17.8 18.3 21.6 24.1 22.0

1 8 2 6 6 13 2 10 1 0 12 2 1 4 0 4 2 10 8 8 3 4 0 3 1 2 0 2 0 5 0 1 3 1 11 8 43 25 15 99 77 22 1 8 6 0 10 0 0 2 0

0 0 0 0 0 0 0 0 0 8 0 0 0 2 1 0 0 0 0 0 0 4 15 0 0 0 1 0 3 0 43 0 0 0 5 51 0 0 4 0 0 0 0 0 0 3 0 0 3 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,145.64 957.57 1,141.68 1,417.74 1,082.50 1,531.78 1,345.64 1,142.52 1,212.63 2,329.22 1,351.69 1,398.72 942.46 1,540.73 2,315.14 1,449.63 1,295.66 1,955.95 1,818.93 1,675.91 909.40 1,762.91 2,525.32 844.48 1,625.83 1,225.69 1,363.69 1,786.97 1,862.98 1,681.80 1,225.62 1,218.56 773.47 1,498.74 1,457.81 1,613.91 767.42 1,479.69 1,295.68 1,388.75 1,002.55 1,036.58 965.39 1,197.49 1,594.66 1,892.95 723.42 1,965.86 1,309.70 860.46 1,533.72

Table S1 page 18/159

Polyadenylate-binding protein 1

PABP1_HUMAN PABPC1

70,653

100.00%

17

19

73

VTELQPR 29.90% ALDTMNFDVIK EFSPFGTITSAK FSPAGPILSIR GFGFVCFSSPEEATK GFGFVSFER IVATKPLYVALAQR KEFSPFGTITSAK NFGEDMDDER NFGEDMDDERLK NLDDGIDDERLR QAHLTNQYMQR QTELKR SGVGNIFIK SKVDEAVAVLQAHQAK SLGYAYVNFQQPADAER VANTSTQTMGPRPAAAAAAATPAVR

FACT complex subunit SSRP1

SSRP1_HUMAN SSRP1

Protein SET

SET_HUMAN

SET

81,060

99.90%

2

2

3

33,471

100.00%

8

12

148

YQGVNLYVK 2.68% ASSGLLYPLER LFDFVNAK 31.40% EFHLNESGDPSSK EQQEAIEHIDEVQNEIDR EQQEAIEHIDEVQNEIDRLNEQASEEILK

Poly(rC)-binding protein 1

PCBP1_HUMAN PCBP1

37,480

100.00%

2

2

12

Flavin reductase

BLVRB_HUMAN BLVRB

22,101

100.00%

5

6

28

HLA class I histocompatibility antigen, A-11 alpha chain

1A11_HUMAN HLA-A

40,919

100.00%

4

4

33

IDFYFDENPYFENK KPRPPPALGPEETSASAGLPK LNEQASEEILK LNEQASEEILKVEQK VEVTEFEDIK 9.27% ESTGAQVQVAGDMLPNSTER IITLTGPTNAIFK 42.70% LPSEGPRPAHVVVGDVLQAADVDK LQAVTDDHIR NDLSPTTVMSEGAR TVAGQDAVIVLLGTR YVAVMPPHIGDQPLTGAYTVTLDGR

CD109 antigen

18.40% APWIEQEGPEYWDQETR DGEDQTQDTELVETRPAGDGTFQK

CD109_HUMAN CD109

161,674

100.00%

33

41

575

SWTAADMAAQITK WAAVVVPSGEEQR 24.40% ADGNQLTLEER ADGNQLTLEERR AEQEGGMQFWVSSESK AKEALNMLTWR ALSEFAALMNTER AYFLGSK DYIDGVYDNAEYAER EALNMLTWR ELLYQR ELSYMVVSR FLIDTHNR GDVTLTFLPLSFWGK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

40.4 73.5 49.8 62.9 61.6 34.4 63.1 67.8 45.2 39.2 36.6 39.9 32.2 67.8 46.0 97.2 43.8 43.2 37.3 36.4 77.4 96.5 60.4 86.6 79.9 59.6 96.7 76.7 107.0 53.3 88.9 43.7 73.1 121.0 67.4 97.9 67.8 76.3 55.7 78.1 68.6 93.8 56.7 98.9 44.2 98.4 60.8 32.0 54.0 55.2 47.6

20.4 21.7 22.1 21.0 19.8 22.3 10.8 21.4 8.5 18.3 22.4 22.1 24.1 19.9 19.5 21.3 21.0 20.8 22.7 20.9 20.5 21.7 20.5 19.1 19.6 23.3 21.1 23.6 21.7 16.4 19.8 23.2 21.5 17.9 21.2 18.7 20.8 22.7 23.0 22.5 22.2 19.0 22.6 22.0 19.7 18.8 23.0 22.7 21.8 22.9 20.7

3 12 6 11 1 3 2 2 3 1 2 2 1 6 0 5 0 2 1 2 29 2 0 32 0 13 3 57 2 10 0 4 6 9 0 2 0 5 14 32 0 16 2 38 7 8 14 4 10 13 2

0 0 0 0 0 0 7 0 0 0 0 3 0 0 2 0 2 0 0 0 1 2 1 0 2 0 5 0 0 0 4 0 0 0 4 0 12 0 0 0 2 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

842.47 1,282.64 1,284.65 1,157.67 1,662.75 1,045.51 1,542.94 1,412.74 1,243.45 1,484.63 1,430.69 1,405.66 774.45 934.54 1,693.92 1,928.91 2,397.23 1,083.58 1,205.65 953.51 1,446.65 2,195.02 3,449.67 1,840.81 2,100.15 1,273.66 1,757.93 1,208.61 2,105.98 1,388.82 2,469.31 1,167.61 1,493.69 1,512.88 2,687.35 2,133.95 2,637.19 1,393.68 1,427.73 1,245.61 1,401.71 1,815.79 1,348.70 1,468.71 785.42 1,792.77 1,133.58 821.45 1,083.55 1,015.53 1,680.90

Table S1 page 19/159

Serine/threonine-protein phosphatase PTPA_HUMAN PPP2R4 2A activator

Heat shock cognate 71 kDa protein

HSP7C_HUMAN HSPA8

40,650

100.00%

6

7

19

70,882

100.00%

42

60

1243

IEFPILEDSSELQLK IPVQLVFK ISVFIQTDK ISVTQPDSIVGIVAVDK IVTLFSDFKPYK LKELSYMVVSR LSDSWQPR NNVVITVTQR NSLGGFASTQDTTVALK SNGEFWDPGR SNLIQQWLSQQSDLGVISK SSMAVHSLFK SYSQSILLDLTDNR TLSFSFPPNTVTGSER TLTLPSLPLNSADEIYELR TNIQVTVTGPSSPSPVK TRDENIK TYIQLK VGSPFELVVSGNK VGSPFELVVSGNKR VIHSELQGGNK 20.90% FGSLLPIHPVTSG FPVIQHFK LVALLNTLDR QPPPDSSEEAPPATQNFIIPK VDDQIAIVFK WIDETPPVDQPSR 61.00% ARFEELNADLFR ATVEDEK CNEIINWLDK DAGTIAGLNVLR EIAEAYLGK FDDAVVQSDMK FEELNADLFR FELTGIPPAPR GPAVGIDLGTTYSCVGVFQHGK GTLDPVEK HWPFMVVNDAGRPK IINEPTAAAIAYGLDK IINEPTAAAIAYGLDKK ITITNDKGR LDKSQIHDIVLVGGSTR LLQDFFNGK LSKEDIER MKEIAEAYLGK MVNHFIAEFK MVNHFIAEFKR MVQEAEK MVQEAEKYK NQTAEKEEFEHQQK NQVAMNPTNTVFDAK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

104.0 57.2 52.2 99.5 59.6 46.1 68.6 52.6 101.0 50.9 122.0 39.9 92.4 79.8 101.0 105.0 35.9 33.1 90.7 81.5 35.3 63.3 33.1 76.9 47.0 49.0 51.2 53.8 32.9 51.4 109.0 50.7 88.0 56.2 35.9 52.1 46.9 61.0 114.0 129.0 64.4 86.0 50.0 62.1 71.7 46.7 34.3 49.8 32.2 69.7 106.0

21.5 17.0 21.5 18.3 20.9 20.9 21.7 20.7 21.9 17.9 20.3 24.1 22.0 22.0 20.0 20.4 24.5 19.1 22.3 20.3 22.6 20.5 23.0 19.1 21.3 21.8 23.2 22.1 23.2 24.2 22.0 21.7 19.8 22.7 19.7 21.4 21.5 22.6 21.5 17.0 22.3 19.3 22.1 23.4 22.1 22.9 22.7 23.2 23.3 20.9 22.6

50 22 7 42 23 2 15 3 25 6 37 4 26 49 46 8 3 2 15 17 1 6 1 5 1 2 3 2 2 2 100 10 12 31 1 0 10 0 30 25 20 6 13 19 26 21 1 3 3 6 60

2 0 0 1 1 2 0 0 0 0 4 0 0 0 2 0 0 0 0 9 3 0 0 0 1 0 0 21 0 0 0 0 0 0 0 24 0 53 4 21 0 27 0 0 52 5 1 0 0 8 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,760.93 943.60 1,050.58 1,740.97 1,457.80 1,340.72 988.49 1,143.65 1,709.87 1,164.51 2,144.14 1,106.57 1,624.82 1,739.86 2,145.14 1,711.92 875.46 765.45 1,332.72 1,488.82 1,181.63 1,324.73 1,015.57 1,127.68 2,263.13 1,147.64 1,539.74 1,480.75 791.38 1,304.63 1,199.68 993.53 1,270.56 1,253.62 1,197.66 2,263.12 858.46 1,669.83 1,659.90 1,787.99 1,017.57 1,838.01 1,081.57 989.53 1,268.66 1,235.62 1,407.72 834.40 1,125.56 1,745.81 1,665.79

Table S1 page 20/159

NQVAMNPTNTVFDAKR NSLESYAFNMK NTTIPTK QATKDAGTIAGLNVLR QTQTFTTYSDNQPGVLIQVYEGER

RFDDAVVQSDMK RNTTIPTK SFYPEEVSSMVLTK SINPDEAVAYGAAVQAAILSGDK

Heterogeneous nuclear ribonucleoprotein U-like protein 1

HNRL1_HUMAN HNRNPUL1

95,722

100.00%

5

5

16

Chromobox protein homolog 3

CBX3_HUMAN CBX3

20,794

100.00%

6

7

19

Elongation factor 1-gamma

EF1G_HUMAN EEF1G

50,101

100.00%

12

13

79

Purine nucleoside phosphorylase

PNPH_HUMAN PNP

32,100

100.00%

14

17

116

SQIHDIVLVGGSTR STAGDTHLGGEDFDNR TTPSYVAFTDTER TVTNAVVTVPAYFNDSQR VCNPIITK VEIIANDQGNR VQVEYK VQVEYKGETK YKAEDEK 8.88% EALGGQALYPHVLVK HLPSTEPDPHVVR NYILDQTNVYGSAQR QGAPTSFLPPEASQLKPDR WDVLIQQATQCLNR 45.40% GFTDADNTWEPEENLDCPELIEAFLNSQK IIGATDSSGELMFLMK KVEEAEPEEFVVEK SLSDSESDDSK VEEAEPEEFVVEK WKDSDEADLVLAK 25.60% AKDPFAHLPK ALIAAQYSGAQVR EYFSWEGAFQHVGK FAETQPK ILGLLDAYLK KLDPGSEETQTLVR LDPGSEETQTLVR MAQFDAK QAFPNTNR STFVLDEFKR TFLVGER WFLTCINQPQFR 51.20% ANHEEVLAAGK DHINLPGFSGQNPLR DHINLPGFSGQNPLRGPNDER FEVGDIMLIR FGDRFPAMSDAYDR FPAMSDAYDR LEQFVSILMASIPLPDK LEQFVSILMASIPLPDKAS LGADAVGMSTVPEVIVAR LTQAQIFDYGEIPNFPR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

83.9 89.2 36.0 58.2 75.4 68.8 39.2 102.0 134.0 87.1 75.2 106.0 89.9 38.8 80.0 37.3 54.7 36.8 63.0 43.4 94.8 34.7 86.9 46.2 97.2 84.4 63.7 58.1 58.2 42.1 92.8 48.2 33.4 63.5 76.4 66.9 31.1 32.1 51.7 35.5 46.2 63.4 64.7 22.6 58.2 46.7 55.8 53.6 32.2 79.8 69.4

22.6 20.6 24.6 19.0 21.2 21.3 22.1 22.3 21.7 21.0 17.4 21.6 21.8 24.7 22.6 22.1 22.5 22.0 18.1 22.1 21.6 21.1 22.7 17.9 22.3 23.0 17.0 22.7 23.1 21.0 21.2 21.2 23.8 13.0 22.2 22.3 18.9 22.6 21.3 22.7 22.2 23.4 22.8 20.9 22.1 19.2 16.5 19.2 20.2 21.1 21.7

4 50 1 0 13 20 2 83 38 38 27 97 52 5 56 2 24 2 2 0 2 0 1 0 6 3 2 3 2 0 11 2 4 19 6 4 1 1 9 1 3 8 6 0 17 0 4 2 1 19 5

1 0 0 2 43 6 0 1 4 16 26 0 9 0 0 0 1 0 0 8 0 3 0 1 0 2 0 0 0 11 0 0 0 0 7 0 0 0 0 0 0 7 9 0 0 5 0 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,821.89 1,303.60 774.44 1,627.91 2,774.33 1,426.66 930.54 1,632.78 2,260.15 1,481.81 1,691.73 1,487.70 1,982.00 944.52 1,228.63 765.41 1,180.62 882.42 1,594.90 1,483.77 1,741.85 2,039.06 1,744.88 3,382.51 1,744.85 1,661.83 1,169.48 1,533.73 1,489.75 1,123.63 1,347.74 1,684.78 820.42 1,118.68 1,572.82 1,444.73 826.38 947.47 1,241.65 821.45 1,609.80 1,138.59 1,664.85 2,333.14 1,192.64 1,647.72 1,172.50 1,917.04 2,075.11 1,800.95 2,009.01

Table S1 page 21/159

Vimentin

VIME_HUMAN VIM

53,635

100.00%

3

3

63

3.43%

Asparaginyl-tRNA synthetase, cytoplasmic

SYNC_HUMAN NARS

62,926

100.00%

10

11

21

23.40%

UTP--glucose-1-phosphate uridylyltransferase

UGPA_HUMAN UGP2

56,924

100.00%

3

4

9

7.48%

Cullin-4B

CUL4B_HUMAN CUL4B

103,969

100.00%

4

4

5

4.93%

tRNA-nucleotidyltransferase 1, mitochondrial Ras-related protein Rab-5C

TRNT1_HUMAN TRNT1

50,112

100.00%

2

2

3

5.76%

RAB5C_HUMAN RAB5C

23,465

100.00%

3

3

6

17.10%

Ras-related C3 botulinum toxin substrate 1 6-phosphofructokinase type C

RAC1_HUMAN RAC1

21,433

100.00%

2

2

5

12.50%

K6PP_HUMAN PFKP

85,579

100.00%

3

3

4

6.51%

Annexin A2

ANXA2_HUMAN ANXA2

38,588

100.00%

28

37

986

69.90%

LVFGFLNGR STVPGHAGR VFGFSLITNK VIMDYESLEK FLEQQNK KLLEGEESR LLEGEESR EDGTFYEFGEDIPEAPER EGIDPTPYYWYTDQR EPFPTIYVDSQKENER FLTWILNR IFDSEEILAGYK KEDGTFYEFGEDIPEAPER LTESVDVLMPNVGEIVGGSMR MNYSDAIVWLK NLMFLVLR SPAGSIVHELNPNFQPPK GLPDNISSVLNK IQRPPEDSIQPYEK SFENSLGINVPR ETVEEQASTTER LPENYTDETWQK QYQIDAAIVR TIDGILLLIER EIGALLQQLR LQSPEFQSLFTEGLK GVDLQENNPASR LVLLGESAVGK QASPNIVIALAGNK LTPITYPQGLAMAK YLECSALTQR AIGVLTSGGDAQGMNAAVR EIGWTDVGGWTGQGGSILGTK NVIFQPVAELK AEDGSVIDYELIDQDAR AYTNFDAER AYTNFDAERDALNIETAIK DALNIETAIK DIISDTSGDFR DIISDTSGDFRK DLYDAGVKR ELASALK GLGTDEDSLIEIICSR GVDEVTIVNILTNR LMVALAK LSLEGDHSTPPSAYGSVK LYDSMK QDIAFAYQR RAEDGSVIDYELIDQDAR SALSGHLETVILGLLK SEVDMLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

62.5 39.3 75.8 47.7 47.6 56.2 43.0 68.1 52.6 29.8 41.5 38.0 34.7 77.0 57.1 40.9 70.8 31.7 57.5 67.0 31.7 48.6 49.8 40.1 51.3 58.4 73.8 43.1 43.5 55.1 46.2 80.9 100.0 34.8 101.0 66.7 72.7 74.5 75.3 57.6 47.6 37.7 98.8 105.0 44.8 77.1 34.8 82.0 99.0 89.0 35.4

21.0 22.1 20.0 22.2 24.2 23.9 23.5 18.3 20.2 22.0 19.8 22.7 19.7 22.3 22.4 18.9 22.7 22.2 22.0 23.1 20.7 21.4 23.0 14.9 18.1 21.2 21.7 20.1 18.2 20.8 21.9 22.8 22.0 20.3 21.0 19.4 22.1 24.5 20.8 22.4 23.2 23.5 22.4 21.3 24.2 22.5 18.9 22.3 22.3 11.1 22.8

4 1 19 7 58 1 4 2 2 0 2 1 0 2 4 2 2 1 2 4 1 1 2 1 2 1 2 2 2 4 1 1 2 1 31 14 38 23 6 6 4 1 74 116 12 15 1 79 22 36 4

0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 34 0 0 0 0 0 0 30 0 3 0 0 82 36 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,022.58 881.46 1,125.63 1,242.59 906.47 1,060.56 932.47 2,100.90 1,903.85 1,951.94 1,062.61 1,384.70 2,229.00 2,235.10 1,339.67 1,021.59 1,932.00 1,256.69 1,699.87 1,332.69 1,379.63 1,523.70 1,176.64 1,255.76 1,140.67 1,723.89 1,299.63 1,085.66 1,395.80 1,519.82 1,240.60 1,803.90 2,119.05 1,257.72 1,908.88 1,086.49 2,155.07 1,087.60 1,225.57 1,353.67 1,036.54 731.43 1,777.86 1,542.85 745.46 1,844.90 756.36 1,111.55 2,064.98 1,650.98 837.40

Table S1 page 22/159

Profilin-2

PROF2_HUMAN PFN2

15,028

99.50%

2

2

3

Aldo-keto reductase family 1 member C1

AK1C1_HUMAN AKR1C1

36,771

100.00%

4

5

27

SLYYYIQQDTK SLYYYIQQDTKGDYQK SVPHLQK SYSPYDMLESIR SYSPYDMLESIRK TDLEKDIISDTSGDFR TKGVDEVTIVNILTNR TNQELQEINR TPAQYDASELK VYKEMYK WISIMTER 19.30% EGFFTNGLTLGAK SQGGEPTYNVAVGR 45.50% AIDGLNR EEPWVDPNSPVLLEDPVLCALAK

HIDSAHLYNNEEQVGLAIR IADGSVKR LAIEAGFR LNDGHFMPVLGFGTYAPAEVPK

Actin-related protein 2/3 complex subunit 5 Aldo-keto reductase family 1 member B10

Desmocollin-3

ARPC5_HUMAN ARPC5

16,303

99.50%

2

2

3

AK1BA_HUMAN AKR1B10

36,003

100.00%

16

17

117

DSC3_HUMAN DSC3

99,953

100.00%

11

11

29

QLEMILNKPGLK QNVQVFEFQLTSEEMK REDIFYTSK RQLEMILNKPGLK RTPALIALR SIGVSNFNR TPALIALR YQLQR 16.60% ALAAGGVGSIVR QGNMTAALQAALK 55.70% ACNVLQSSHLEDYPFDAEY AKMPIVGLGTWK ALGVSNFSHFQIEK ATFLDAWEAMEELVDEGLVK DDKGNAIGGK HIDCAYVYQNEHEVGEAIQEK IKEIAAK IVENIQVFDFK LLNKPGLK LSDEEMATILSFNR MPIVGLGTWK NVIVIPK REDLFIVSK SGDDLFPK TAAQVLIR VAIDAGYR 10.50% AVALSDK AVALSDKK EVTVLLEHQK GVDKEPLNLFYIER NAGFQEYTIPITVK SFTIWLSDK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

74.2 71.4 30.7 76.7 64.6 87.7 92.7 69.0 75.0 38.2 37.0 35.5 58.2 37.0 29.4 82.9 45.2 46.2 59.8 56.0 91.6 38.6 28.1 37.6 53.8 70.5 30.5 83.8 56.9 53.9 29.8 83.6 101.0 35.9 38.9 40.3 99.3 32.4 92.3 59.7 41.1 50.8 60.7 61.2 33.0 40.4 35.3 53.3 31.6 74.8 52.5

23.0 21.7 19.2 21.1 23.0 22.2 18.1 23.6 23.1 22.8 22.2 22.6 22.2 22.6 21.3 22.0 23.3 23.1 21.7 17.6 21.3 21.6 14.5 10.0 22.6 14.8 22.5 19.8 23.0 17.4 19.2 23.0 21.5 22.0 20.3 19.8 21.2 11.5 22.4 21.4 13.6 21.1 22.3 21.0 23.8 25.8 21.9 19.2 21.7 21.6 21.6

86 3 1 28 21 16 6 71 39 4 5 1 2 2 0 0 1 52 3 9 5 15 0 2 6 31 2 2 1 2 0 10 2 2 0 2 24 2 23 11 2 11 10 11 1 1 2 4 0 2 5

0 2 0 0 0 25 10 0 0 0 0 0 0 0 1 56 0 0 16 0 0 0 2 0 0 0 0 0 0 0 1 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,421.70 2,012.96 808.47 1,460.67 1,588.77 1,811.87 1,771.99 1,244.62 1,222.60 976.48 1,051.52 1,354.70 1,434.70 758.42 2,591.31 2,179.09 845.48 876.49 2,360.18 1,383.80 1,972.93 1,158.58 1,539.90 1,010.65 993.51 854.55 707.38 1,070.63 1,316.70 2,257.97 1,300.75 1,576.81 2,282.09 974.49 2,532.15 772.49 1,351.73 882.58 1,625.78 1,101.61 782.51 1,106.62 878.43 871.54 864.46 703.40 831.49 1,195.67 1,692.90 1,580.83 1,096.57

Table S1 page 23/159

60S ribosomal protein L12

RL12_HUMAN RPL12

Deleted in malignant brain tumors 1 DMBT1_HUMAN DMBT1 protein

17,801

100.00%

5

5

13

38.20%

260,708

100.00%

4

4

31

1.78%

37,989

100.00%

9

9

248

28.80%

Follistatin

FST_HUMAN

Inositol monophosphatase 1

IMPA1_HUMAN IMPA1

30,171

100.00%

2

2

4

8.66%

Actin-related protein 2/3 complex subunit 1B

ARC1B_HUMAN ARPC1B

40,932

100.00%

3

4

19

11.30%

Adapter molecule crk

CRK_HUMAN CRK

33,813

100.00%

5

5

11

25.30%

Proline synthase co-transcribed bacterial homolog protein

PROSC_HUMAN PROSC

30,326

100.00%

7

7

20

32.40%

Nucleolin

NUCL_HUMAN NCL

76,598

100.00%

28

33

416

35.20%

FST

SSDPDFR VILNVPSK VILNVPSKLEADK VLNDGSVYTAR VNLEECFR CTGGEVGATSALAPK HSGNITFDEIVNIAR IGPLGLSPK KVGDDIAK QAQIEVVPSASALIIK FGQGSGPIVLDDVR LVNGDGR LVNGGDR QLGCGWATSAPGNAR CKEQPELEVQYQGR CVCAPDCSNITWK EQPELEVQYQGR GPVCGLDGK GRCSLCDELCPDSK LSTSWTEEDVNDNTLFK SIGLAYEGK TELSKEECCSTGR TYRNECALLK SLLVTELGSSR SSPVDLVTATDQK ASSEGGTAAGAGLDSLHK EVEERPAPTPWGSK TWKPTLVILR ALFDFNGNDEEDLPFK DSSTSPGDYVLSVSENSR IGDQEFDSLPALLEFYK IHYLDTTTLIEPVSR QEAVALLQGQR APLEVAQEH HGLPPSETIAIVEHINAK IGSTIFGER LMAVPNLFMLETVDSVK TFGENYVQELLEK TKPADMVIEAYGHGQR VQQAVAR ALELTGLK ALVATPGKK EALNSCNKR EAMEDGEIDGNK EAMEDGEIDGNKVTLDWAKPK EVFEDAAEIR FGYVDFESAEDLEK GFGFVDFNSEEDAK GIAYIEFK GLSEDTTEETLK GLSEDTTEETLKESFDGSVR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

49.2 36.7 54.3 91.4 38.2 94.4 40.3 50.5 40.0 49.5 93.7 37.0 37.0 43.9 38.9 61.2 81.1 33.6 34.7 110.0 57.8 32.3 33.0 64.5 74.2 95.1 49.1 48.2 83.1 74.0 91.9 37.3 73.4 33.3 34.5 63.7 63.8 79.1 62.7 45.2 58.9 32.0 38.2 72.2 48.7 70.9 97.9 81.0 45.0 71.5 94.7

20.1 14.0 16.6 23.6 22.2 22.6 22.1 11.5 23.4 12.8 22.5 21.9 21.9 21.1 24.6 17.2 22.2 21.6 16.6 21.6 21.3 16.9 22.6 21.9 24.0 21.9 22.4 14.8 20.8 19.2 22.5 21.0 20.4 23.3 20.0 22.0 21.8 23.3 22.0 18.9 20.7 16.3 21.8 14.1 21.3 23.5 19.2 17.4 20.2 22.7 21.3

2 2 2 4 4 2 1 4 2 4 26 1 1 3 0 5 10 1 12 174 41 1 0 2 2 6 1 0 2 2 2 0 4 1 0 2 5 7 0 2 20 1 1 13 0 8 13 59 18 13 5

0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 3 0 0 2 0 10 0 0 0 1 0 0 2 0 0 0 1 0 0 0 0 0 4 0 0 0 0 0 22

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

823.36 869.55 1,425.83 1,194.61 1,066.50 1,418.70 1,685.86 881.55 845.47 1,666.97 1,459.75 730.38 730.38 1,545.72 1,763.84 1,610.68 1,475.71 902.44 1,525.65 1,998.93 937.50 1,556.67 1,267.65 1,161.65 1,360.70 1,628.79 1,582.79 1,226.76 1,870.85 1,899.86 1,984.99 1,757.94 1,212.67 993.50 1,926.05 979.52 1,938.99 1,569.78 1,788.87 771.45 844.51 884.56 1,091.53 1,323.54 2,362.12 1,178.57 1,648.74 1,561.68 940.51 1,322.63 2,200.03

Table S1 page 24/159

IVTDRETGSSK KFGYVDFESAEDLEK KGAAIPAK NDLAVVDVR NSTWSGESK QGTEIDGR QKVEGTEPTTAFNLFVGNLNFNK

Triosephosphate isomerase

TPIS_HUMAN TPI1

26,651

100.00%

19

30

637

SISLYYTGEK TEADAEKTFEEK TGISDVFAK TLVLSNLSYSATEETLQEVFEK VAVATPAK VAVATPAKK VEGTEPTTAFNLFVGNLNFNK VTLDWAKPK VTQDELK VTQDELKEVFEDAAEIR 89.60% DCGATWVVLGHSER EAGITEK ELASQPDVDGFLVGGASLKPEFVDIINAK

RNA-binding protein FUS

FUS_HUMAN FUS

53,408

100.00%

5

6

11

FFVGGNWK HVFGESDELIGQK IAVAAQNCYK IIYGGSVTGATCK KFFVGGNWK KQSLGELIGTLNAAK QSLGELIGTLNAAK RHVFGESDELIGQK SNVSDAVAQSTR TATPQQAQEVHEK VAHALAEGLGVIACIGEK VIADNVKDWSK VPADTEVVCAPPTAYIDFAR VTNGAFTGEISPGMIK VVFEQTK VVLAYEPVWAIGTGK 12.70% AAIDWFDGK AAIDWFDGKEFSGNPIK APKPDGPGGGPGGSHMGGNYGDDR

Heterogeneous nuclear ribonucleoproteins C1/C2

HNRPC_HUMAN HNRNPC

33,653

100.00%

9

10

94

Protocadherin-1

PCDH1_HUMAN PCDH1

114,726

100.00%

10

11

114

GEATVSFDDPPSAK TGQPMINLYTDR 30.40% AAVAGEDGR GFAFVQYVNER LKGDDLQAIK MIAGQVLDINLAAEPK NDKSEEEQSSSSVK QKVDSLLENLEK VDSLLENLEK VFIGNLNTLVVK VPPPPPIAR 11.60% DMNDNAPTIEIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

49.8 77.6 40.9 70.8 53.8 58.5 49.0 52.0 65.8 55.6 129.0 47.7 33.5 109.0 48.6 40.7 94.3 88.2 32.2 67.6 32.3 89.2 58.8 115.0 38.0 99.7 102.0 64.9 98.2 77.8 119.0 57.7 78.0 99.0 45.1 112.0 62.3 37.3 28.0 76.7 41.0 53.5 85.8 37.5 99.1 72.4 54.0 48.2 85.2 32.4 76.7

22.9 22.1 18.1 21.6 20.4 22.0 20.8 23.7 21.4 20.9 21.1 15.4 16.3 21.6 21.4 24.5 21.9 21.5 24.5 18.4 20.7 22.9 23.2 22.5 21.3 16.5 21.0 22.5 22.7 22.7 20.2 23.4 21.8 22.4 21.9 19.4 22.3 22.6 16.8 21.7 22.7 20.6 22.3 21.3 19.7 19.8 21.3 24.0 13.6 18.1 20.3

1 2 1 24 12 19 0 19 9 34 17 3 1 42 3 12 7 15 1 0 4 38 18 16 3 21 28 3 42 64 30 11 6 14 5 124 2 1 0 3 2 2 12 1 16 6 4 4 46 2 16

0 0 0 0 0 0 2 0 4 0 3 0 0 12 0 0 12 12 0 51 0 37 0 0 2 22 1 8 0 5 45 0 2 5 0 4 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,192.62 1,776.83 755.48 1,000.54 995.44 875.42 2,568.31 1,160.58 1,397.64 937.50 2,501.27 756.46 884.56 2,312.16 1,057.60 832.44 1,991.99 1,586.74 747.39 3,029.58 954.48 1,458.72 1,137.57 1,326.67 1,082.58 1,542.89 1,414.79 1,614.82 1,234.60 1,466.72 1,807.97 1,274.67 2,192.07 1,621.83 850.47 1,602.89 1,022.49 1,894.93 2,268.97 1,420.66 1,424.68 845.41 1,329.66 1,100.63 1,682.92 1,553.69 1,415.77 1,159.62 1,316.79 943.57 1,404.64

Table S1 page 25/159

Poliovirus receptor

PVR_HUMAN PVR

45,284

100.00%

2

3

32

6.00%

S-adenosylmethionine synthase isoform type-2

METK2_HUMAN MAT2A

43,643

100.00%

6

7

25

16.70%

Filaggrin-2

FILA2_HUMAN FLG2

248,034

100.00%

3

3

24

1.71%

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase Aldehyde dehydrogenase family 1 member A3

DHX15_HUMAN DHX15

90,917

99.90%

2

2

6

3.14%

AL1A3_HUMAN ALDH1A3

56,091

100.00%

15

19

60

35.20%

EQQSTYTFQLK GLFTISPETGEIQVK LEVGAPYLR NTGLITVQGPVDREDLSTLR TGDIFTTETSIDR VQDGGSPPR VTVLDTNDNAPK WDSYDLTIK YFLQTTTPLDYEK VLAKPQNTAEVQK VQLTGEPVPMAR AAVDYQK DSFPWEVPK FVIGGPQGDAGLTGR HIGYDDSSK TQVTVQYMQDR YLDEDTIYHLQPSGR FSNSSSSNEFSK HQEEESETEEDEEDTPGHK QDGECGTLSK EVDDLGPEVGDIK TLATDILMGVLK ANSTDYGLTAAVFTK AVEAAQVAFQR EAGFPPGVVNIVPGFGPTVGAAISSHPQINK

Alpha-actinin-4

ACTN4_HUMAN ACTN4

104,839

100.00%

61

80

2114

EEIFGPVQPILK ELGEYALAEYTEVK GLFIKPTVFSEVTDNMR IAFTGSTEVGK IAKEEIFGPVQPILK IFINNEWHESK ILELIESGK ILELIESGKK KRPVGDPFDVK LLHQLADLVER TEQGPQIDQK VFVEEQVYSEFVR 70.70% AGTQIENIDEDFR AGTQIENIDEDFRDGLK AIMTYVSSFYHAFSGAQK ALDFIASK ASFNHFDKDHGGALGPEEFK ASIHEAWTDGK CQLEINFNTLQTK DDPVTNLNNAFEVAEK DGLAFNALIHR DHALLEEQSK DHGGALGPEEFK DLLLDPAWEK DYETATLSDIK EAILAIHK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

42.1 59.7 32.1 59.3 81.5 52.3 89.0 32.3 60.6 60.2 59.6 35.8 30.5 88.8 43.1 60.7 61.5 71.1 62.0 32.2 49.4 60.7 112.0 56.3 36.7 54.8 71.8 43.8 52.9 65.7 60.8 36.5 51.0 33.9 47.0 52.2 79.6 72.7 87.9 87.6 64.7 45.0 48.0 92.7 86.6 60.7 59.8 44.6 50.4 70.9 55.5

21.6 22.0 21.8 19.6 22.3 21.1 22.9 23.2 22.8 18.8 21.2 22.5 22.3 22.7 19.8 22.1 22.1 16.1 10.0 18.2 22.4 19.0 23.1 23.9 18.8 18.8 22.3 21.4 21.1 14.0 21.9 19.3 18.2 22.0 17.9 21.5 22.3 20.7 22.0 22.3 21.2 20.3 20.6 22.9 22.0 21.6 23.2 21.1 22.0 21.7 15.2

5 13 6 2 2 13 20 1 19 16 13 3 1 6 6 2 4 22 0 1 1 5 3 2 0 2 4 1 4 2 2 2 2 0 2 5 14 5 11 31 17 0 20 4 14 26 8 2 7 22 14

0 0 0 17 0 0 0 0 0 3 0 0 0 0 0 0 3 0 1 0 0 0 0 0 4 0 0 3 0 2 0 0 2 2 2 0 0 0 16 13 0 17 0 0 0 4 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,372.68 1,618.87 1,017.57 2,184.16 1,455.70 912.45 1,286.66 1,140.56 1,618.80 1,425.81 1,297.69 794.40 1,104.54 1,444.76 1,021.46 1,384.65 1,806.87 1,320.57 2,254.89 1,094.48 1,385.68 1,290.73 1,558.78 1,189.63 3,057.62 1,369.77 1,614.79 1,970.01 1,109.58 1,681.99 1,416.69 1,001.59 1,129.68 1,257.70 1,306.75 1,143.56 1,630.81 1,507.70 1,920.93 2,023.96 864.48 2,203.02 1,214.58 1,608.81 1,775.85 1,226.66 1,169.58 1,256.59 1,199.63 1,255.61 894.54

Table S1 page 26/159

EGLLLWCQR ELPPDQAEYCIAR ETTDTDTADQVIASFK FAIQDISVEETSAK GISQEQMQEFR GYEEWLLNEIR HEAFESDLAAHQDR HRDYETATLSDIK HRPELIEYDK HRPELIEYDKLR HTNYTMEHIR IAESNHIK ICDQWDALGSLTHSR ISIEMNGTLEDQLSHLK KDDPVTNLNNAFEVAEK KHEAFESDLAAHQDR LASDLLEWIR LDHLAEK LMLLLEVISGER LSGSNPYTTVTPQIINSK LSNRPAFMPSEGK LVSIGAEEIVDGNAK MAPYQGPDAVPGALDYK MEEIGR MLDAEDIVNTARPDEK MTLGMIWTIILR MVSDINNGWQHLEQAEK NFITAEELR NVNVQNFHISWK QFASQANVVGPWIQTK QGEAEFNR QLEAIDQLHLEYAK QQSNEHLR RQFASQANVVGPWIQTK STLPDADR STLPDADRER TFTAWCNSHLR TINEVENQILTR TIPWLEDR TIPWLEDRVPQK TIQEMQQK VEQIAAIAQELNELDYYDSHNVNTR

Splicing factor, arginine/serine-rich 2 SFRS2_HUMAN SFRS2

3-hydroxyisobutyrate

3HIDH_HUMAN HIBADH

25,459

100.00%

3

3

33

35,312

100.00%

7

8

18

VGWEQLLTTIAR VLAGDKNFITAEELR VLAVNQENEHLMEDYEK VQQLVPK YLDIPK 14.50% DAEDAMDAMDGAVLDGR VDNLTYR VGDVYIPR 31.80% DFSSVFQFLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

48.2 73.8 114.0 104.0 72.7 101.0 51.6 71.0 41.8 39.2 41.5 56.8 97.7 42.6 109.0 48.4 101.0 45.8 43.2 104.0 57.7 114.0 102.0 30.8 94.6 97.4 83.7 47.7 59.0 111.0 67.1 86.0 30.4 50.7 34.4 42.1 33.2 86.4 30.7 39.9 39.8 107.0 92.8 117.0 88.6 53.3 35.7 122.0 31.0 65.1 36.7

23.4 21.1 21.2 22.3 21.0 23.5 20.1 22.8 22.3 20.4 20.6 20.1 20.7 22.4 21.8 21.5 22.0 19.3 19.6 21.3 23.1 22.0 22.2 23.0 22.0 20.2 21.1 23.3 22.2 21.9 21.5 21.7 20.8 20.6 21.7 22.3 22.0 22.5 22.7 20.7 22.5 20.7 20.5 20.5 21.8 15.4 19.0 13.8 23.1 22.8 22.7

26 14 78 225 48 73 0 6 0 0 0 13 8 0 29 0 38 13 1 57 19 180 53 3 20 49 8 7 8 39 5 52 1 0 1 7 1 61 1 9 4 0 180 12 8 12 14 15 1 17 1

0 0 3 0 0 0 4 34 44 2 15 0 27 9 66 6 0 0 0 4 31 0 0 0 38 0 6 0 0 2 0 4 0 4 0 17 0 0 0 0 0 44 0 21 17 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,174.60 1,561.73 1,741.81 1,537.78 1,368.62 1,421.71 1,625.73 1,548.77 1,299.67 1,568.86 1,301.61 911.50 1,758.82 1,943.98 1,903.94 1,753.83 1,215.67 825.45 1,388.78 1,920.01 1,433.72 1,514.81 1,808.85 734.35 1,832.87 1,479.81 2,014.93 1,092.57 1,485.76 1,773.93 950.43 1,670.88 1,011.50 1,930.03 874.43 1,159.57 1,392.65 1,429.77 1,029.54 1,481.81 1,021.50 2,905.40 1,386.77 1,675.90 2,060.96 811.50 748.42 1,783.71 880.45 918.51 1,245.63

Table S1 page 27/159

dehydrogenase, mitochondrial

Bone morphogenetic protein 1

BMP1_HUMAN BMP1

111,231

100.00%

13

13

73

UPF0568 protein C14orf166

CN166_HUMAN C14orf166

28,051

100.00%

3

3

6

22,022

99.50%

2

2

4

138,335

100.00%

2

2

4

Peptidyl-prolyl cis-trans isomerase F, PPIF_HUMAN PPIF mitochondrial TPP2_HUMAN TPP2 Tripeptidyl-peptidase 2

DLGLAQDSATSTK EFQDAGEQVVSSPADVAEK GSLLIDSSTIDPAVSK MGAVFMDAPVSGGVGAAR SPILLGSLAHQIYR TPVGFIGLGNMGNPMAK 15.70% AAAFLGDIALDEEDLR AGFAVNFFK DYGHIQSPNYPDDYRPSK ENIQPGQEYNFLK FVSDGSINK FYSDNSVQR GDIAQAR GGGPQAISIGK GIFLDTIVPK KPEPVLATGSR LPEPIVSTDSR YCGSGPPEEVYSAGDSVLVK YCGYEKPDDIK 15.60% AGVMALANLLQIQR LTQDAVAK NAEPLINLDVNNPDFK 18.40% FPDENFTLK GSGDPSSSSSSGNPLVYLDVDANGKPLGR

Heterogeneous nuclear ribonucleoprotein D-like

HNRDL_HUMAN HNRPDL

46,421

99.50%

2

2

2

Polypeptide Nacetylgalactosaminyltransferase 2

GALT2_HUMAN GALNT2

64,715

100.00%

12

12

31

Inositol-3-phosphate synthase 1

INO1_HUMAN ISYNA1

61,050

100.00%

4

4

11

Translin

TSN_HUMAN TSN

26,165

99.50%

2

4

6

SUMO-conjugating enzyme UBC9

UBC9_HUMAN UBE2I

17,990

100.00%

3

4

10

1.84% GTLTEAFPVLGGK VPITAVIAAK 10.00% DLTEYLSR FGEVVDCTIK GFGFVLFK VFVGGLSPDTSEEQIK 25.20% AAEVWMDEYK EIILVDDYSNDPEDGALLGK FNQVESDKLR FYFEELGK GGFDWNLVFK NFYYAAVPSAR QHPYTFPGGSGTVFAR QKWEQIEGNSK TPMIAGGLFVMDK VRGADAAQAK WDYMTPEQR WPDFNQEAYVGGTMVR 8.78% APLVPPGSPVVNALFR VFVGGDDFK VGPVAATYPMLNK VIVLWTANTER 15.40% EAVTEILGIEPDREK EILTLLQGVHQGAGFQDIPK 20.30% KDHPFGFVAVPTK MLFKDDYPSSPPK VEYEKR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

67.3 90.3 48.3 87.7 51.0 63.3 88.4 63.7 20.4 72.3 31.3 49.6 45.5 59.6 46.8 39.2 60.0 111.0 42.3 58.5 30.4 74.2 42.8 73.8 56.4 37.5 31.1 55.7 40.5 35.2 44.1 127.0 29.8 30.2 43.6 53.8 55.8 41.3 63.1 32.0 48.5 61.7 32.4 31.2 48.7 72.8 59.4 75.8 47.1 81.1 31.4

22.7 20.0 21.0 21.4 18.5 22.2 22.3 21.6 20.2 22.8 22.5 20.0 21.9 18.9 18.2 19.9 22.3 21.0 19.1 19.5 23.4 21.9 22.5 20.7 21.1 7.8 21.8 22.7 22.9 22.6 19.1 22.1 23.5 22.3 21.7 21.9 22.6 22.9 21.9 21.3 16.9 20.6 15.8 21.6 22.4 21.4 21.5 17.9 21.4 22.7 22.0

2 2 2 5 2 3 3 18 0 12 2 2 6 2 10 2 12 2 1 3 1 2 2 0 2 2 1 13 13 1 2 7 0 1 2 2 0 2 5 1 2 3 2 1 4 4 1 1 2 2 2

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 2 0 0 0 2 0 0 0 0 0 0 0 0 0 2 2 4 0 0

0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,306.65 2,005.94 1,602.86 1,724.81 1,567.90 1,735.85 1,718.86 1,000.53 2,151.97 1,579.78 966.49 1,115.51 730.38 984.55 1,102.65 1,154.65 1,213.64 2,113.98 1,387.62 1,513.85 845.47 1,812.91 1,110.55 2,833.36 1,289.71 982.63 996.50 1,167.57 914.51 1,705.87 1,257.55 2,176.07 1,235.64 1,032.50 1,182.59 1,258.62 1,721.84 1,346.67 1,411.70 986.54 1,241.53 1,885.85 1,633.94 983.48 1,360.73 1,301.72 1,698.89 2,164.18 1,442.78 1,540.74 823.43

Table S1 page 28/159

Cleavage and polyadenylation specificity factor subunit 6 Complement factor D

CPSF6_HUMAN CPSF6

59,193

99.50%

2

2

2

CFAD_HUMAN CFD

27,014

100.00%

3

4

23

Lysyl oxidase homolog 4

LOXL4_HUMAN LOXL4

84,463

100.00%

10

13

53

42,806

99.50%

2

2

3

Nucleosome assembly protein 1-like NP1L4_HUMAN NAP1L4 4 Hexokinase-1

HXK1_HUMAN HK1

102,470

100.00%

12

13

28

Thioredoxin reductase 1, cytoplasmic

TRXR1_HUMAN TXNRD1

70,889

100.00%

9

11

19

7.08% AVSDASAGDYGSAIETLVTAISLIK TPLSEAEFEEIMNR 22.10% AVPHPDSQPDTIDHDLLLLQLSEK RPDSLQHVLLPVLDR VQVLLGAHSLSQPEPSK 17.10% AQEVVMSGVR FSTQIYNLGR GSWAEEPR GYLSETVSNALGPQGR LGQGLGPIHLSEVR LVGPESKPEEGR QHSPVTEGAVEVK SADHMDWPYGYR VVCGMLGFPSEVPVDSHYYR YGQGEGPIWLDNVR 10.10% AAATAEEPDPK FYEEVHDLER LDNVPHTPSSYIETLPK 16.00% ASGVEGADVVK ATDCVGHDVVTLLR GAALITAVGVR GAAMVTAVAYR GDFIALDLGGSSFR GKFNTSDVSAIEK HIDLVEGDEGR ITPELLTR LRTEASS LVDEYSLNAGK SANLVAATLGAILNR TPDGTENGDFLALDLGGTNFR 17.60% FLIATGERPR KLMHQAALLGQALQDSR LMHQAALLGQALQDSR MIEAVQNHIGSLNWGYR QFVPIKVEQIEAGTPGR VEQIEAGTPGR VMVLDFVTPTPLGTR VVGFHVLGPNAGEVTQGFAAALK

UPF0027 protein C22orf28

CV028_HUMAN C22orf28

55,192

99.50%

2

2

4

Plakophilin-1

PKP1_HUMAN PKP1

82,845

100.00%

3

3

5

Insulin-like growth factor-binding protein 5

IBP5_HUMAN IGFBP5

30,552

100.00%

5

7

61

Complement factor B

CFAB_HUMAN CFB

85,515

100.00%

6

6

11

VVYENAYGQFIGPHR 4.95% QIGNVAALPGIVHR SYNDELQFLEK 5.09% LLQSGNSDVVR SPNQNVQQAAAGALR VMGNQVFPEVTR 22.80% EHEEPTTSEMAEETYSPK FVGGAENTAHPR HMEASLQELK IISAPEMR QDEEKPLHALLHGR 9.42% EAGIPEFYDYDVALIK EKLQDEDLGFL

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

51.5 51.9 41.9 44.9 32.0 65.3 67.2 42.4 88.6 48.7 41.1 49.5 34.2 46.4 70.6 45.1 48.4 28.3 35.8 67.0 38.3 54.4 35.0 63.2 53.3 35.0 37.3 74.7 77.9 109.0 34.8 34.0 39.7 44.5 62.3 58.0 99.9 69.9 61.4 31.4 35.8 48.2 104.0 32.2 92.6 76.8 44.7 37.7 42.8 61.4 44.5

19.6 22.6 20.6 16.6 19.0 23.7 21.0 17.6 23.3 19.5 22.0 22.2 15.9 21.0 22.0 21.8 21.0 21.0 23.3 22.1 18.6 22.5 22.3 22.0 21.9 18.2 22.5 23.2 17.9 21.5 22.0 20.5 21.3 22.2 18.4 22.1 21.0 18.1 22.5 17.2 20.5 22.2 22.1 22.7 15.2 22.1 21.4 23.6 20.9 22.4 23.3

1 1 0 0 0 7 8 4 7 2 1 2 0 0 7 2 4 0 2 1 1 1 2 2 3 1 1 2 4 1 2 0 0 0 2 2 4 0 1 0 2 2 2 1 4 18 11 6 0 2 2

0 0 3 16 2 0 0 0 0 8 2 2 1 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 7 0 0 1 2 1 1 0 0 2 1 2 0 0 0 0 6 0 0 0 7 0 0

0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,452.28 1,665.78 2,681.38 1,758.00 1,789.98 1,091.55 1,198.62 931.43 1,648.83 1,475.83 1,297.68 1,380.71 1,497.62 2,328.08 1,603.79 1,099.53 1,336.62 1,910.99 1,031.54 1,555.79 1,027.63 1,125.57 1,454.73 1,395.71 1,239.60 942.56 763.40 1,208.62 1,483.86 2,210.04 1,159.66 1,896.01 1,767.92 2,003.98 1,869.02 1,156.60 1,661.89 2,282.23 1,749.87 1,444.84 1,385.66 1,187.64 1,524.79 1,376.70 2,094.88 1,255.62 1,201.59 932.49 1,642.87 1,842.92 1,306.65

Table S1 page 29/159

F-actin-capping protein subunit alpha-1

CAZA1_HUMAN CAPZA1

32,905

100.00%

13

16

83

QLNEINYEDHK VASYGVKPR VSEADSSNADWVTK YGLVTYATYPK 67.50% DVQDSLTVSNEAQTAK EASDPQPEEADGGLK EGAAHAFAQYNMDQFTPVK ESCDSALR FITHAPPGEFNEVFNDVR FTITPPTAQVVGVLK IEGYEDQVLITEHGDLGNSR IIENAENEYQTAISENYQTMSDTTFK

IQVHYYEDGNVQLVSHK KEASDPQPEEADGGLK LLLNNDNLLR TIDGQQTIIACIESHQFQPK VSDEEKVR HLA class I histocompatibility antigen, Cw-12 alpha chain

1C12_HUMAN HLA-C

40,867

99.50%

2

2

12

Cystatin-C

CYTC_HUMAN CST3

15,781

100.00%

9

12

108

Insulin-like growth factor-binding protein 6

IBP6_HUMAN IGFBP6

25,304

100.00%

4

6

732

13,509

100.00%

3

3

5

Small nuclear ribonucleoprotein Sm SMD2_HUMAN SNRPD2 D2 Mesothelin

MSLN_HUMAN MSLN

68,970

100.00%

13

15

123

Drebrin-like protein

DBNL_HUMAN DBNL

48,188

100.00%

4

4

12

16.40% DGEDQTQDTELVETRPAGDGTFQK FDSDAASPR SWTAADTAAQITQR WAAVVVPSGEEQR 62.30% AFCSFQIYAVPWQGTMTLSK ALDFAVGEYNK ASNDMYHSR KQIVAGVNYFLDVELGR LVGGPMDASVEEEGVR LVGGPMDASVEEEGVRR QIVAGVNYFLDVELGR RALDFAVGEYNK TQPNLDNCPFHDQPHLK 16.20% APAVAEENPK GAQTLYVPNCDHR HLDSVLQQLQTEVYR RHLDSVLQQLQTEVYR 24.60% EEEEFNTGPLSVLTQSVK NNTQVLINCR REEEEFNTGPLSVLTQSVK 20.80% ANVDLLPR EIDESLIFYK FVAESAEVLLPR GLLPVLGQPIIR GSLLSEADVR IQSFLGGAPTEDLK LLGPHVEGLK LLGPHVEGLKAEER LLPAALACWGVR LRTDAVLPLTVAEVQK QLDVLYPK TDAVLPLTVAEVQK VNAIPFTYEQLDVLK 13.50% FQDVGPQAPVGSVYQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

33.7 43.4 94.2 67.7 98.7 90.3 30.5 43.4 51.1 65.7 61.2 61.3 40.7 73.6 72.5 66.1 59.3 67.8 63.5 81.4 55.7 57.9 70.7 73.0 102.0 106.0 37.8 115.0 38.5 71.2 73.9 43.4 129.0 53.7 89.0 62.3 34.5 31.3 56.9 55.6 50.5 53.9 84.0 43.8 48.4 40.0 96.4 47.3 101.0 67.5 102.0

21.9 20.8 20.6 22.8 23.4 19.5 20.6 18.3 21.7 14.8 22.1 18.5 22.2 22.0 19.2 22.1 24.0 20.8 22.1 23.7 23.0 21.2 22.9 18.1 18.1 21.2 21.3 20.7 22.9 21.7 20.9 20.8 21.8 20.2 22.1 23.4 22.2 17.6 22.4 21.6 9.0 23.7 23.3 17.0 19.6 20.5 14.0 21.1 19.5 20.0 22.1

1 2 2 2 6 14 0 1 2 10 0 0 0 2 14 1 2 0 6 6 14 6 38 8 6 12 5 19 2 2 393 6 238 0 2 2 0 2 9 4 6 8 30 2 0 3 10 6 10 16 4

0 0 0 0 0 0 3 0 4 0 5 3 11 1 0 0 0 12 0 0 0 0 0 0 3 0 4 3 0 0 0 3 91 1 0 0 1 0 0 0 0 0 0 4 2 0 11 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,402.66 976.56 1,508.69 1,275.66 1,705.82 1,542.69 2,140.98 937.41 2,089.01 1,570.92 2,245.07 3,056.37 2,029.01 1,670.79 1,197.70 2,314.15 961.50 2,637.19 965.43 1,519.75 1,427.73 2,351.12 1,226.61 1,080.45 1,921.05 1,660.79 1,800.89 1,792.96 1,382.71 2,060.96 1,025.53 1,530.71 1,828.96 1,985.06 2,006.99 1,231.62 2,163.09 897.52 1,256.64 1,330.74 1,275.82 1,046.55 1,475.77 1,062.63 1,547.85 1,326.74 1,753.02 975.55 1,483.84 1,749.94 1,719.87

Table S1 page 30/159

Protein S100-A16

S10AG_HUMAN S100A16

11,784

100.00%

4

4

6

Small nuclear ribonucleoproteinassociated proteins B and B' Thrombospondin-1

RSMB_HUMAN SNRPB

24,593

100.00%

2

2

11

TSP1_HUMAN THBS1

129,364

100.00%

25

28

433

VAGTGEGGLEEMVEELNSGK VKDPNSGLPK YQEQGGEASPQR 36.90% AADKLIQNLDANHDGR AVIVLVENFYK LIHEQEQQSSS LIQNLDANHDGR 9.58% GENLVSMTVEGPPPK VLGLVLLR 25.00% AQGYSGLSVK CEGSSVQTR DHSGQVFSVVSNGK DLASIAR FQMIPLDPK FTGSQPFGQGVEHATANK FVFGTTPEDILR FYVVMWK GFLLLASLR GGVNDNFQGVLQNVR GPDPSSPAFR GTLLALER GTSQNDPNWVVR IEDANLIPPVPDDKFQDLVDAVR

Nucleoprotein TPR

TPR_HUMAN TPR

TRI29_HUMAN TRIM29 Tripartite motif-containing protein 29 AN32B_HUMAN ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B

267,271

100.00%

11

11

20

65,818

100.00%

2

2

3

28,771

100.00%

3

4

40

IMADSGPIYDK IPESGGDNSVFDIFELTGAAR KIMADSGPIYDK LCNNPTPQFGGK LVPNPDQK MENAELDVPIQSVFTR NALWHTGNTPGQVR QVTQSYWDTNPTR SITLFVQEDR TIVTTLQDSIR VTEENKELANELR 5.80% ASTALSNEQQAR EGVQGPLNVSLSEEGK ELENANDLLSATK LDELQASDVSVK LQEQVTDLR NIEELQQQNQR NLQEQTVQLQSELSR QTEEQVNDLKER SQEQILEILR TETMNVVMETNK TLSSVQNEVQEALQR 3.06% EQDAVDQVK VIMDALDER 28.70% DISTLEPLK IFGGLDMLAEK KLELSENR LKDISTLEPLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

87.5 45.1 65.5 60.6 65.6 39.6 28.5 70.4 52.1 37.2 55.8 61.7 41.6 44.9 83.3 69.2 43.3 61.6 93.9 50.2 59.8 52.2 56.0 55.2 133.0 51.8 62.0 38.2 117.0 55.9 97.2 53.9 66.4 53.7 53.3 41.7 53.1 63.4 59.3 61.4 96.3 33.7 54.5 64.6 86.7 39.4 33.0 33.0 62.3 46.1 50.2

21.4 20.0 23.3 22.7 17.4 20.9 22.6 23.2 6.0 20.2 20.3 22.7 25.5 24.0 22.3 22.6 23.3 13.8 23.5 20.3 21.8 21.2 20.0 23.2 22.2 22.7 22.6 19.6 22.6 22.3 22.1 23.3 21.2 23.1 22.6 22.4 22.6 24.4 23.1 21.3 21.8 22.2 24.8 20.0 22.2 21.9 23.6 21.5 22.4 23.4 17.5

2 0 4 0 2 1 0 6 5 2 1 1 4 11 17 79 1 8 56 7 8 22 0 12 7 2 15 3 51 5 21 2 64 2 4 1 1 2 2 2 1 1 3 1 2 1 2 3 21 6 6

0 2 0 2 0 0 1 0 0 0 0 0 0 0 4 0 0 0 1 0 0 0 26 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,021.93 1,054.59 1,349.61 1,750.88 1,294.74 1,285.60 1,365.69 1,554.78 882.61 1,009.53 1,023.45 1,460.71 745.42 1,088.58 1,875.90 1,394.73 988.50 989.61 1,616.81 1,030.50 872.52 1,372.66 2,579.34 1,209.58 2,195.06 1,353.67 1,332.64 910.50 1,864.91 1,550.78 1,595.75 1,207.63 1,246.70 1,544.79 1,275.63 1,642.83 1,417.72 1,303.67 1,101.59 1,399.69 1,772.91 1,488.73 1,228.69 1,428.64 1,701.88 1,031.50 1,077.53 1,015.57 1,209.62 988.54 1,256.75

Table S1 page 31/159

UBA3_HUMAN UBA3 NEDD8-activating enzyme E1 catalytic subunit Puromycin-sensitive aminopeptidase PSA_HUMAN NPEPPS

51,835

99.50%

2

2

2

103,261

100.00%

22

25

86

Nuclear autoantigenic sperm protein NASP_HUMAN NASP

85,218

100.00%

4

5

16

LLPQLTYLDGYDR LPNLTHLNLSGNK SLDLFNCEVTNLNDYR 5.83% IQDFNDTFYR LQEVLDYLTNSASLQMK 28.10% AFFESHPAPSAER AGIISTVEVLK ATLEEAR DAESIHQYLLQR DLSLPPVDR DNWEELYNR DYFNVPYPLPK ETALLIDPK IDFVGELNDK KPYPDDENLVEVK LGLQNDLFSLAR LGWDPKPGEGHLDALLR LNLGTVGFYR LSVEGFAVDK SPVYLTVLK TIQQCCENILLNAAWLK TQYSSAMLESLLPGIR VALSNMNVIDR VLGATLLPDLIQK VTLSFPSTLQTGTGTLK YAAVTQFEATDAR YQGGFLISR 7.49% EAEGSSAEYKK EAQLYAAQAHLK EIEELKELLPEIR HLVMGDIPAAVNAFQEAASLLGK

Small proline-rich protein 2E

SPR2E_HUMAN SPRR2E

7,837

100.00%

4

4

88

Transitional endoplasmic reticulum ATPase

TERA_HUMAN VCP

89,307

100.00%

28

34

195

66.70% CPEPCPPPK CPPVTPSPPCQPK CPQPCPPQQCQQK QPCQPPPVCPTPK 42.80% AFEEAEK AIANECQANFISIK DVDLEFLAK ELQELVQYPVEHPDK ETVVEVPQVTWEDIGGLEDVKR

EVDIGIPDATGR GGNIGDGGGAADR GILLYGPPGTGK GPELLTMWFGESEANVR GVLFYGPPGCGK IVSQLLTLMDGLK KAFEEAEK KGDIFLVR KYEMFAQTLQQSR LAGESESNLR LAGESESNLRK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

69.2 76.2 103.0 49.3 86.5 39.4 62.0 47.2 64.8 30.0 49.9 47.8 34.1 56.2 43.0 86.9 34.1 61.2 56.3 48.9 68.2 69.0 74.2 91.2 76.0 99.6 54.2 39.0 47.8 66.4 38.8 52.2 32.6 54.9 47.2 35.8 63.5 63.3 73.4 81.2 71.2 75.1 58.7 55.2 35.2 112.0 32.0 45.2 95.2 73.9 54.4

21.9 19.9 20.7 20.5 22.0 21.1 18.2 24.9 21.6 21.6 19.8 22.7 20.5 23.8 23.1 21.6 21.1 21.6 23.5 14.0 22.3 22.5 23.8 11.8 17.9 21.2 21.0 21.5 21.8 18.8 20.8 20.0 22.0 18.1 23.1 20.0 22.6 23.0 22.3 20.5 21.9 20.1 21.2 21.6 22.8 17.9 23.0 17.6 22.1 22.7 23.6

4 6 5 1 1 2 5 2 2 1 2 6 2 2 2 7 0 3 2 3 2 2 4 18 2 3 4 1 2 5 0 69 1 2 16 2 2 6 4 2 9 5 9 2 1 20 1 11 3 4 6

0 7 0 0 0 0 0 0 2 0 0 0 0 0 0 0 6 0 0 0 0 1 0 0 0 0 0 0 0 1 7 0 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 2 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,566.82 1,420.79 1,972.91 1,318.61 1,969.00 1,445.68 1,129.68 789.41 1,472.75 1,011.55 1,238.54 1,352.69 999.57 1,149.58 1,545.78 1,346.74 1,873.99 1,139.62 1,064.56 1,019.61 2,075.04 1,781.91 1,231.65 1,380.85 1,750.96 1,442.69 1,040.55 1,198.56 1,342.71 1,610.90 2,368.23 1,081.48 1,464.70 1,655.71 1,505.72 823.38 1,578.80 1,049.55 1,823.92 2,498.28 1,242.63 1,116.50 1,172.67 1,951.92 1,251.62 1,446.82 951.48 947.57 1,629.81 1,075.54 1,203.63

Table S1 page 32/159

Peptidyl-prolyl cis-trans isomerase FKBP4

FKBP4_HUMAN FKBP4

51,788

100.00%

10

10

49

Eukaryotic initiation factor 4A-I

IF4A1_HUMAN EIF4A1

46,137

100.00%

15

18

65

LDQLIYIPLPDEK LGDVISIQPCPDVK LIVDEAINEDNSVVSLSQPK MDELQLFR NAPAIIFIDELDAIAPK NVFIIGATNRPDIIDPAILRPGR QAAPCVLFFDELDSIAK QTNPSAMEVEEDDPVPEIR RIVSQLLTLMDGLK SVSDNDIR VINQILTEMDGMSTK WALSQSNPSALR 29.00% AEASSGDHPTDTEMKEEQK ATESGAQSAPLPMEGVDISPK AWDIAIATMK EGTGTEMPMIGDR FEIGEGENLDLPYGLER LAEEENKAK LYANMFER QDEGVLK RGEAHLAVNDFELAR SNTAGSQSQVETEA 39.40% ATQALVLAPTR DFTVSAMHGDMDQK DQIYDIFQK EELTLEGIR ELAQQIQK ENYIHR GFKDQIYDIFQK GIYAYGFEKPSAIQQR GYDVIAQAQSGTGK KEELTLEGIR LNSNTQVVLLSATMPSDVLEVTK

SAP domain-containing ribonucleoprotein

SARNP_HUMAN SARNP

23,653

100.00%

6

6

12

Mucin-2

MUC2_HUMAN MUC2

540,252

100.00%

6

6

37

Eukaryotic translation initiation factor 3 subunit G

EIF3G_HUMAN EIF3G

35,594

100.00%

3

3

4

LQMEAPHIIVGTPGR MFVLDEADEMLSR QFYINVER VLITTDLLAR 34.30% FGISSVPTK FGIVTSSAGTGTTEDTEAK FGLNVSSISR FNVPVSLESK GLSSDNKPMVNLDK ITSEIPQTER 1.35% HETQEVLIK SNNDFTTR TASGLVEATGAGFANTWK TCGCVGPDNVPR TFDGDVFR TVHMMPMQVQVQVNR 7.19% ADDNATIR LPGELEPVQATQNK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

78.0 52.9 110.0 63.1 95.9 30.1 69.4 76.8 45.5 36.7 94.9 77.9 45.0 72.8 62.8 52.4 104.0 40.0 46.6 35.9 45.2 75.9 55.3 43.4 32.3 32.5 39.3 34.0 67.4 71.7 121.0 48.1 64.9 58.5 105.0 38.2 55.7 49.7 98.5 47.7 31.8 69.6 48.8 38.2 39.2 102.0 35.6 45.5 41.2 47.5 39.6

20.3 22.0 20.8 23.0 18.6 12.8 21.6 20.3 14.8 22.5 22.7 22.9 16.6 21.6 23.3 17.1 22.1 24.0 19.4 23.0 22.0 17.4 18.1 14.1 23.4 23.7 20.5 21.0 22.8 21.2 23.1 22.7 19.5 21.3 20.5 22.6 17.6 20.9 21.6 22.0 23.6 22.4 23.5 19.6 18.8 22.8 19.0 20.3 21.8 22.0 21.4

14 1 5 6 34 0 8 4 2 2 9 10 0 7 2 9 8 1 2 2 0 6 3 2 1 1 5 1 4 3 4 2 2 4 11 2 10 3 2 2 2 2 1 5 2 20 1 5 0 2 1

0 0 0 0 2 1 2 0 2 0 0 0 10 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 2 0 1 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,556.86 1,540.80 2,170.12 1,051.52 1,811.00 2,518.43 1,923.95 2,171.98 1,586.93 905.43 1,679.84 1,329.69 2,105.89 2,101.01 1,135.58 1,425.60 1,950.95 1,031.54 1,059.49 788.42 1,697.87 1,408.62 1,140.67 1,613.66 1,169.58 1,059.57 957.54 831.41 1,501.77 1,827.94 1,394.69 1,187.66 2,475.30 1,618.87 1,571.71 1,068.55 1,114.68 935.52 1,871.89 1,079.58 1,119.60 1,533.76 1,173.61 1,096.60 954.43 1,780.89 1,331.58 956.45 1,845.88 875.42 1,523.81

Table S1 page 33/159

Eukaryotic translation initiation factor 5A-1

IF5A1_HUMAN EIF5A

16,815

100.00%

8

11

27

RADDNATIR 55.20% EDLRLPEGDLGK IVEMSTSK KYEDICPSTHNMDVPNIK LPEGDLGKEIEQK NDFQLIGIQDGYLSLLQDSGEVR

TPP1_HUMAN TPP1

61,230

100.00%

6

6

13

6-phosphogluconate dehydrogenase, 6PGD_HUMAN PGD decarboxylating

53,124

100.00%

11

12

103

46,424

100.00%

14

15

46

Tripeptidyl-peptidase 1

NGFVVLK VHLVGIDIFTGK VHLVGIDIFTGKK 16.00% ILSGRPPLGFLNPR LFGGNFAHQASVAR LSELVQAVSDPSSPQYGK LYQQHGAGLFDVTR VNTELMK YLTLENVADLVRPSPLTLHTVQK

Serpin H1

SERPH_HUMAN SERPINH1

26.90% AGQAVDDFIEK FQDTDGK GILFVGSGVSGGEEGAR HEMLPASLIQAQR IISYAQGFMLLR LVPLLDTGDIIIDGGNSEYR NPELQNLLLDDFFK SAVENCQDSWR TVSKVDDFLANEAK VDDFLANEAK YGPSLMPGGNK 42.30% AATLAER AVAISLPK AVLSAEQLR AVLSAEQLRDEEVHAGLGELLR DQAVENILVSPVVVASSLGLVSLGGK

Chloride intracellular channel protein CLIC4_HUMAN CLIC4 4

Phosphoglycerate mutase 1

PGAM1_HUMAN PGAM1

28,756

100.00%

9

11

32

28,787

100.00%

17

24

165

DTQSGSLLFIGR GVVEVTHDLQK HLAGLGLTEAIDK HLAGLGLTEAIDKNK LSSLIILMPHHVEPLER LYGPSSVSFADDFVR SAGLAFSLYQAMAK SALQSINEWAAQTTDGK TGLYNYYDDEKEK 47.80% AGSDGESIGNCPFSQR FLDGNEMTLADCNLLPK FSAYIK GVVFSVTTVDLK HPESNTAGMDIFAK LDEYLNSPLPDEIDENSMEDIK LFMILWLK NFDIPK NSRPEANEALER YLTNAYSR 69.70% ALPFWNEEIVPQIK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

33.8 43.7 42.8 33.5 55.9 74.3 51.4 57.5 46.7 30.4 87.2 95.5 54.9 44.4 41.5 61.5 31.1 107.0 53.7 59.8 116.0 80.4 48.0 78.2 77.1 75.6 31.9 37.1 37.3 53.0 73.1 79.8 51.0 46.5 57.2 18.5 71.9 58.1 90.5 51.4 94.2 70.9 34.2 56.0 34.4 51.9 40.8 37.2 39.8 40.1 74.7

22.4 22.5 21.5 21.5 21.4 21.0 19.9 19.2 15.6 13.8 23.1 22.0 22.3 23.8 14.8 23.1 19.3 23.0 22.3 22.3 21.5 22.4 16.1 22.7 23.6 22.3 25.1 15.8 22.0 19.2 14.3 22.9 21.1 19.2 18.5 17.2 21.8 22.4 23.3 20.9 18.6 21.8 19.5 19.0 20.4 20.4 16.6 24.5 21.9 20.5 20.6

1 2 1 0 2 4 2 4 0 0 1 6 0 2 0 7 1 54 4 3 13 2 2 2 8 6 1 1 2 0 1 9 4 2 0 0 7 2 2 2 2 4 4 2 2 5 4 1 5 2 34

0 2 0 2 0 2 0 4 2 1 0 0 2 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 4 6 0 0 0 2 0 0 0 0 0 0 0 0 0 0 2 0 0 3 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,031.52 1,341.70 910.46 2,161.01 1,455.77 2,580.30 776.47 1,298.75 1,426.84 1,536.90 1,474.76 1,904.96 1,604.82 850.43 2,607.45 1,192.59 810.36 1,591.81 1,509.78 1,427.77 2,160.12 1,705.88 1,351.57 1,536.79 1,121.55 1,136.54 731.41 798.51 986.56 2,405.28 2,551.43 1,293.68 1,224.66 1,337.74 1,579.88 1,984.11 1,659.80 1,457.75 1,819.88 1,637.73 1,681.72 1,950.93 728.40 1,264.72 1,533.70 2,579.17 1,079.63 733.39 1,385.68 987.49 1,683.91

Table S1 page 34/159

AMEAVAAQGK FSGWYDADLSPAGHEEAK FSGWYDADLSPAGHEEAKR HGEAQVK HGESAWNLENR HLEGLSEEAIMELNLPTGIPIVYELDK

Serine/threonine-protein phosphatase PPP6_HUMAN PPP6C 6 catalytic subunit

35,127

100.00%

3

4

7

11.10%

HYGGLTGLNK KAMEAVAAQGK NLKPIKPMQFLGDEETVR NLKPIKPMQFLGDEETVRK RGGQALR RSYDVPPPPMEPDHPFYSNISK SYDVPPPPMEPDHPFYSNISK VLIAAHGNSLR YADLTEDQLPSCESLK YADLTEDQLPSCESLKDTIAR APLDLDKYVEIAR GAGWLFGAK VTNEFVHINNLK IQEGVFDINNEANGIK TASNVEEAFINTAK YIIIGDTGVGK AMLESIGVPLEK APWELLELR IDVGEAEPR NSEPEEVIPSR QVEPLDPPAGSAPGEHVFVK VDAQFGGIDQR VSYYENVIK ELAEEKR KLNQALLDLHALGSAR LGGPEAGLGEYLFER HIGLVYSGMGPDYR LAQQYYLVYQEPIPTAQLVQR LVQIEYALAAVAGGAPSVGIK YNEDLELEDAIHTAILTLK

Ras-related protein Rab-2A

RAB2A_HUMAN RAB2A

23,528

100.00%

3

3

8

19.30%

Tyrosyl-tRNA synthetase, cytoplasmic

SYYC_HUMAN YARS

59,127

100.00%

7

7

14

15.30%

Ferritin light chain

FRIL_HUMAN FTL

20,003

100.00%

3

3

5

21.70%

Proteasome subunit alpha type-2

PSA2_HUMAN PSMA2

25,881

100.00%

4

8

47

32.10%

Glutathione synthetase

GSHB_HUMAN GSS

52,368

100.00%

18

18

99

42.80% AIEHADGGVAAGVAVLDNPYPV AIENELLAR ALAEGVLLR ASYILMEK CPDIATQLAGTK EGGGNNLYGEEMVQALK EGIAQTVFLGLNR GLALGIAK GSLDQDR ILSNNPSK QDDFTAR QIEINTISASFGGLASR QQLEELAR QYSLQNWEAR SADGSPALK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

68.3 82.3 41.9 47.5 79.2 34.3 49.6 73.1 54.3 30.3 30.1 43.2 43.7 58.0 87.8 47.0 68.6 47.8 70.8 102.0 101.0 43.7 35.8 41.9 53.7 39.4 30.7 79.3 37.1 36.2 35.3 59.2 73.1 89.0 44.2 119.0 65.2 53.8 73.2 61.6 71.6 72.5 80.6 40.3 33.9 33.0 36.4 124.0 43.1 60.7 44.2

23.2 19.8 20.5 19.5 21.2 19.8 23.0 23.5 20.5 18.5 20.9 20.6 19.9 18.2 20.5 21.0 21.8 21.7 21.5 23.0 23.4 21.7 22.6 20.7 20.8 21.8 22.0 23.7 22.8 24.4 14.8 23.2 22.3 18.8 14.0 20.9 21.9 21.4 16.5 20.2 22.8 21.9 21.1 18.2 19.9 22.3 21.0 21.6 21.4 22.5 22.0

3 8 0 2 12 0 10 5 4 0 1 0 4 12 2 0 1 2 2 2 4 2 2 2 2 2 0 2 2 1 0 2 6 4 1 2 15 4 16 8 3 8 9 2 2 2 4 6 3 6 4

0 19 6 0 1 1 0 1 5 0 0 3 0 9 0 4 2 0 0 0 0 0 0 0 0 0 2 0 0 0 2 0 5 1 18 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 6 10 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

991.49 1,979.88 2,135.98 768.40 1,312.60 3,039.56 1,059.56 1,103.59 2,115.13 2,243.22 757.44 2,589.21 2,433.11 1,150.67 1,868.86 2,425.16 1,502.82 906.48 1,427.76 1,760.88 1,494.74 1,135.64 1,286.70 1,126.63 985.50 1,256.61 2,074.06 1,205.59 1,114.58 874.46 1,719.99 1,607.81 1,580.75 2,521.35 2,027.15 2,201.13 2,135.08 1,028.57 941.58 954.50 1,274.64 1,808.85 1,417.78 742.48 790.37 872.48 852.39 1,763.93 986.53 1,294.62 845.44

Table S1 page 35/159

SDYMFQR TFEDISEK VQQELSRPGMLEMLLPGQPEAVAR

N-acetyl-D-glucosamine kinase

NAGK_HUMAN NAGK

37,359

99.90%

2

2

3

Mucin-4

MUC4_HUMAN MUC4

231,563

100.00%

3

3

4

Exostosin-1

EXT1_HUMAN EXT1

86,239

100.00%

5

6

23

Catenin alpha-1

CTNA1_HUMAN CTNNA1

100,055

100.00%

4

5

17

Coatomer subunit epsilon

COPE_HUMAN COPE

34,465

100.00%

5

5

11

Glutamine synthetase

GLNA_HUMAN GLUL

42,047

100.00%

4

4

6

Cleavage and polyadenylation specificity factor subunit 5

CPSF5_HUMAN NUDT21

26,210

100.00%

5

6

14

Eukaryotic translation initiation factor 3 subunit C

EIF3C_HUMAN EIF3C

105,329

100.00%

3

3

6

Ig kappa chain C region

IGKC_HUMAN IGKC

11,591

99.50%

2

2

15

Integrin alpha-2

ITA2_HUMAN ITGA2

129,280

100.00%

4

4

6

Dipeptidyl peptidase 9

DPP9_HUMAN DPP9

98,246

100.00%

5

5

7

Heterogeneous nuclear ribonucleoprotein Q

HNRPQ_HUMAN SYNCRIP

69,586

100.00%

10

10

52

7.85% AGVDPLVPLR HIVAVLPEIDPVLFQGK 1.89% IGLASALQPR NDVVFQPISGEDVR TEGLLGVWNNNPEDDFR 9.25% ASISTENFRPNFDVSIPLFSK IAESYQNILAAIEGSR IVLTTLEIIQDR LLLQIPSTIR YLTGIGSDTR 6.73% LLEPLVTQVTTLVNTNSK NAGNEQDLGIQYK TSVQTEDDQLIAGQSAR WDDSGNDIIVLAK 20.50% APPAPGPASGGSGEVDELFDVK AYLAQR FGVVLDEIKPSSAPELQAVR KFGVVLDEIKPSSAPELQAVR LQDAYYIFQEMADK 11.30% GGLDNAR QVYMSLPQGEK RPAETNLR VQAMYIWIDGTGEGLR 26.90% LFLVQLQEK LMTEILGR LPGGELNPGEDEVEGLK TINLYPLTNYTFGTK YIQQTKPLTLER 3.18% ELLGQGLLLR FEELTNLIR LGSLVENNER 35.80% TVAAPSVFIFPPSDEQLK VDNALQSGNSQESVTEQDSK 5.17% FVQGLDIGPTK IGQTSSSVSFK QIPAAQEQPFIVSNQNK VDISLENPGTSPALEAYSETAK 7.65% AGKPYQLQIYPNER ELVQPFSSLFPK LSGPDDDPLHK LYYLGMPYGSR SQGYDWSEPFSPGEDEFK 20.70% AGPIWDLR DLFEDELVPLFEK DSDLSHVQNK EAAQEAVK EFNEDGALAVLQQFK LMMDPLTGLNR

95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

30.9 43.2 26.2 45.2 46.9 65.0 41.5 77.3 26.9 92.8 30.0 45.7 44.7 98.2 63.0 84.4 73.4 88.3 31.1 52.8 33.0 86.2 30.7 42.8 38.5 54.3 66.4 41.0 76.8 74.2 52.2 48.0 48.4 57.1 68.6 140.0 55.4 36.6 31.7 84.3 31.0 39.0 33.7 38.7 54.1 39.9 75.9 51.8 37.7 44.6 50.8

13.0 21.1 20.8 17.8 12.3 16.9 22.1 20.5 20.8 22.6 17.1 9.5 22.0 15.8 22.5 22.3 22.8 22.3 23.7 18.2 16.0 22.6 19.3 21.8 19.8 22.5 18.8 21.4 22.3 22.3 19.4 16.7 22.5 22.6 20.3 20.1 22.6 21.7 21.8 22.4 22.4 20.9 23.1 22.2 16.0 21.3 23.0 21.1 22.0 23.1 23.2

1 5 0 1 0 1 2 1 0 7 1 4 4 6 4 4 2 2 1 0 0 4 1 2 2 1 2 2 2 4 2 2 2 2 11 4 2 2 1 1 0 2 1 2 1 2 23 6 5 3 5

0 0 1 0 2 0 0 0 1 6 0 0 0 1 0 0 0 0 0 3 1 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

962.40 968.46 2,681.38 1,036.62 1,875.07 1,025.61 1,574.78 1,975.92 2,369.21 1,734.90 1,413.83 1,153.73 1,082.55 1,970.12 1,449.70 1,818.88 1,445.73 2,097.01 721.40 2,155.18 2,283.27 1,734.81 702.35 1,295.63 956.53 1,824.90 1,117.66 932.52 1,752.87 1,745.91 1,489.84 1,111.68 1,134.62 1,130.58 1,946.03 2,135.97 1,174.65 1,140.59 1,911.99 2,292.12 1,676.88 1,391.76 1,193.58 1,335.64 2,104.88 927.51 1,593.81 1,142.54 845.44 1,708.85 1,292.63

Table S1 page 36/159

TGYTLDVTTGQR TKEQILEEFSK VTEGLTDVILYHQPDDK VWGNVGTVEWADPIEDPDPEVMAK

5'-nucleotidase domain-containing protein 1

NT5D1_HUMAN NT5DC1

51,830

100.00%

5

6

10

Nardilysin

NRDC_HUMAN NRD1

131,558

100.00%

5

5

11

Aldose reductase

ALDR_HUMAN AKR1B1

35,836

100.00%

7

7

66

16.00% DIVAAIQHNYK MMTPEVLAEAYGK SQRPEESEPLEK TAGYYPNPPLVLSSDETLISK VVYFGDSMHSDIFPAR 4.09% ANLVLLSGANEGK GSLSNAGDPEIVK LGADESEEEGR LGADESEEEGRR TVFQFDVQR 26.30% EELFIVSK GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR

Osteopontin

OSTP_HUMAN SPP1

35,405

100.00%

9

10

52

MPILGLGTWK NLVVIPK REELFIVSK SPPGQVTEAVK TTAQVLIR VAIDVGYR 37.60% AIPVAQDLNAPSDWDSR ANDESNEHSDVIDSQELSK DSYETSQLDDQSAETHSHK GKDSYETSQLDDQSAETHSHK ISHELDSASSEVN KANDESNEHSDVIDSQELSK QLYNKYPDAVATWLNPDPSQK QNLLAPQNAVSSEETNDFKQETLPSK

SYIM_HUMAN IARS2 Isoleucyl-tRNA synthetase, mitochondrial TNF6B_HUMAN TNFRSF6B Tumor necrosis factor receptor superfamily member 6B Neuroblast differentiation-associated AHNK_HUMAN AHNAK protein AHNAK

113,776

100.00%

2

2

3

32,661

99.50%

2

2

18

629,086

100.00%

10

10

85

Ig alpha-1 chain C region

IGHA1_HUMAN IGHA1

37,636

99.50%

2

2

3

Aconitate hydratase, mitochondrial

ACON_HUMAN ACO2

85,410

100.00%

10

11

21

YPDAVATWLNPDPSQK 1.98% DSFLGSIPGK EMTADVIELK 10.30% LLQALEAPEGWGPTPR LTELLGAQDGALLVR 2.19% ADIDVSGPK GEGPDVDVNLPK GEGPEVDVNLPK VDIDVPDVNIEGPDAK VDIDVPDVNIEGPEGK VDIEGPDVNIEGPEGK VDVDIPDVNIEGPDAK VDVDVPDVNIEGPDAK VDVEVPDVSLEGPEGK 7.37% QEPSQGTTTFAVTSILR SAVQGPPER 17.20% DGYAQILR DINQEVYNFLATAGAK DSSGQHVDVSPTSQR EGWPLDIR IVYGHLDDPASQEIER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

43.9 58.2 42.5 43.8 39.7 50.1 46.0 74.0 32.6 104.0 59.2 66.3 50.0 35.7 41.2 33.9 53.7 37.2 45.2 75.6 64.5 47.0 98.1 26.9 43.4 52.4 56.6 43.5 35.5 58.7 81.2 35.1 34.0 54.1 91.7 47.5 55.0 43.2 56.3 50.9 57.3 43.6 72.0 49.0 46.9 37.3 47.6 79.6 43.7 33.2 35.1

22.5 22.3 22.5 21.0 21.7 21.0 22.3 20.8 21.2 21.9 22.9 17.9 19.4 22.2 19.9 18.7 20.5 13.6 20.6 20.5 18.5 22.9 22.7 18.5 16.8 18.1 20.5 20.2 21.1 21.3 22.4 22.5 23.1 21.4 17.7 22.1 22.6 22.3 22.6 22.4 22.4 22.4 22.6 21.6 22.0 21.9 23.3 22.0 21.1 20.8 21.9

2 2 0 1 2 2 2 2 0 4 2 2 0 1 2 0 28 4 16 23 12 7 18 0 0 0 6 0 0 0 6 2 1 7 11 28 15 8 8 4 1 2 13 6 1 2 2 2 2 1 0

0 0 3 0 0 0 1 0 1 0 0 0 2 0 0 2 0 0 0 0 0 0 0 1 4 3 0 3 2 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,311.65 1,351.71 1,942.98 2,670.24 1,271.67 1,471.68 1,428.70 2,265.17 1,856.86 1,285.71 1,286.66 1,191.51 1,347.61 1,139.59 964.54 3,262.68 1,115.63 782.51 1,120.64 1,112.60 901.55 892.49 1,854.90 2,116.93 2,177.92 2,363.04 1,387.63 2,245.02 2,448.22 2,888.43 1,801.88 1,020.54 1,164.58 1,734.92 1,568.90 901.46 1,239.62 1,253.64 1,695.84 1,695.84 1,667.81 1,695.84 1,681.83 1,668.83 1,835.95 940.49 935.50 1,753.88 1,599.74 985.51 1,841.90

Table S1 page 37/159

Cathepsin B

CATB_HUMAN CTSB

37,803

100.00%

10

13

86

26.30%

Protein-arginine deiminase type-3

PADI3_HUMAN PADI3

74,725

100.00%

9

9

19

17.50%

Lamin-B1

LMNB1_HUMAN LMNB1

66,392

100.00%

6

6

13

12.80%

Endoplasmic reticulum resident protein 29

ERP29_HUMAN ERP29

28,977

100.00%

6

6

17

27.60%

NSFL1 cofactor p47

NSF1C_HUMAN NSFL1C

40,555

100.00%

9

12

24

33.80%

LTGSLSGWSSPK NAVTQEFGPVPDTAR QGLLPLTFADPADYNK SQFTITPGSEQIR WVVIGDENYGEGSSR DIMAEIYK HYGYNSYSVSNSEK ICEPGYSPTYK LCGTFLGGPKPPQR LPASFDAR SGVYQHVTGEMMGGHAIR TDQYWEK TDQYWEKI VMFTEDLK VMFTEDLKLPASFDAR ALLFQGVVDDEQVK ATAFFPDLVNMLVLGK HVLGQDK ILGPDFGYVTR ILIGGNLPGSSGR SVSGLDSFGNLEVSPPVVANGK TISINQVLSNK TLPVVFDSPR TQGPAALFDDHK ALYETELADAR IESLSSQLSNLQK IGDTSVSYK IQELEDLLAK LLEGEEER LSSEMNTSTVNSAR NSQGEEVAQR DGDFENPVPYTGAVK ESYPVFYLFR FDTQYPYGEK GALPLDTVTFYK ILDQGEDFPASEMTR SLNILTAFQK ASSSILIDESEPTTNIQIR DLIHDQDEDEEEEEGQR EANLLNAVIVQR LGAAPEEESAYVAGEK LGAAPEEESAYVAGEKR LGSTAPQVLSTSSPAQQAENEAK

Spectrin alpha chain, brain

SPTA2_HUMAN SPTAN1

284,525

100.00%

59

66

256

SGFSLDNGELR SPNELVDDLFK SYQDPSNAQFLESIR 29.40% AALLELWELR ADVVESWIGEK ALINADELASDVAGAEALLDR DLAALEDKVK DLAALGDKVNSLGETAER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

54.7 67.6 69.0 41.4 54.3 33.1 80.1 52.7 53.6 51.1 65.4 38.1 62.5 35.0 45.5 63.1 61.7 36.7 38.2 75.1 34.4 39.2 44.0 36.4 53.2 38.3 30.9 36.4 39.2 67.2 66.6 72.1 43.5 31.5 56.7 92.5 68.3 78.2 105.0 51.8 63.2 67.1 74.0 51.0 62.1 108.0 53.1 43.1 114.0 45.5 43.6

23.1 22.6 22.3 23.2 21.4 21.6 19.1 20.5 21.8 24.5 21.5 19.4 21.5 22.0 22.6 22.5 20.4 20.1 21.7 20.2 21.6 21.6 23.2 21.7 22.8 21.7 20.4 22.9 21.6 22.1 20.4 22.1 23.7 18.9 20.6 21.1 18.1 22.1 14.3 18.9 22.7 22.0 22.1 23.0 23.4 21.5 20.0 23.8 21.4 21.4 22.1

2 2 3 2 2 3 5 6 3 7 1 3 26 2 1 2 4 2 1 3 1 2 2 0 4 1 1 2 2 2 3 2 2 1 5 3 4 1 1 2 2 1 2 2 4 5 5 4 4 3 0

0 0 0 0 0 0 0 0 2 0 15 0 0 0 12 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 1 0 0 0 0 0 2 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,219.63 1,601.79 1,762.90 1,463.75 1,667.77 998.49 1,634.71 1,314.60 1,527.81 876.46 1,961.90 969.43 1,082.52 982.49 1,855.93 1,560.83 1,751.94 796.43 1,237.66 1,240.70 2,173.11 1,216.69 1,130.62 1,299.63 1,251.62 1,446.78 969.49 1,171.66 974.48 1,512.70 1,117.52 1,608.75 1,320.66 1,247.56 1,324.72 1,724.78 1,134.65 2,074.07 2,085.85 1,339.77 1,620.78 1,776.88 2,314.15 1,194.58 1,276.64 1,754.84 1,213.69 1,232.62 2,127.09 1,101.62 1,858.95

Table S1 page 38/159

DLASVQALLR DLIGVQNLLK DLSSVQTLLTK DLTGVQNLR DLTNVQNLQK DLTSWVTEMK DTEQVDNWMSK DVDEIEAWISEK DVDETISWIK DVEDEETWIR DVTGAEALLER EAALTSEEVGADLEQVEVLQK EANELQQWINEK EANQQQQFNR EELYQNLTR EKEPIAASTNR ELPTAFDYVEFTR GKDLIGVQNLLK GLVSSDELAK GNAMVEEGHFAAEDVK GVIDMGNSLIER HQAFEAEVQANSGAIVK IAALQAFADQLIAAGHYAK IDGITIQAR ITALDEFATK KVEDLFLTFAK LAALADQWQFLVQK LDILDQER LFGAAEVQR LGESQTLQQFSR LIQEQHPEEELIK LIQNNHYAMEDVATR LIQSHPESAEDLQEK LLEATELK LLVGSEDYGR LNDSYR LQIASDENYKDPTNLQGK LQQLFR LQQSHPLSATQIQVK LQTASDESYKDPTNIQSK LSDDNTIGKEEIQQR LTVLSEER MNEVISLWK MTLVASEDYGDTLAAIQGLLK NQALNTDNYGHDLASVQALQR NTTGVTEEALK QEQIDNQTR REELITNWEQIR SADESGQALLAAGHYASDEVR SQLLGSAHEVQR SSLSSAQADFNQLAELDR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

72.8 50.5 72.3 59.4 50.9 37.1 44.0 39.0 52.7 72.2 72.3 80.6 69.7 45.0 31.4 26.6 56.6 40.5 32.6 64.2 49.7 29.1 35.3 45.6 45.8 45.0 60.3 35.7 68.3 64.5 54.8 43.5 72.2 31.0 49.3 36.1 77.5 30.8 50.9 76.0 76.9 47.8 43.2 82.8 47.8 31.1 44.2 37.9 61.9 66.2 133.0

21.2 18.6 21.0 22.4 22.3 23.2 17.8 22.4 23.9 20.2 23.5 21.2 21.6 21.6 23.1 23.7 22.6 14.9 24.0 20.1 22.8 22.0 19.8 22.0 22.4 18.8 20.7 21.2 24.1 22.9 21.6 22.4 22.2 20.9 22.3 21.8 22.5 21.2 18.2 21.8 22.7 22.9 23.3 21.3 22.4 23.8 20.7 22.2 21.6 22.2 21.7

8 3 7 3 4 6 1 1 1 9 9 1 4 8 2 0 5 4 2 2 4 0 0 2 6 4 4 1 13 4 5 0 7 1 4 3 1 2 0 3 1 4 5 2 0 1 2 0 0 5 7

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 4 0 1 2 0 0 0 0 0 0 0 0 4 2 0 0 0 3 0 4 3 6 0 0 0 2 0 0 2 8 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,085.63 1,112.67 1,204.68 1,015.55 1,172.63 1,209.58 1,352.58 1,433.68 1,205.61 1,291.58 1,173.61 2,258.14 1,501.73 1,262.59 1,165.59 1,215.63 1,587.77 1,297.78 1,018.54 1,719.76 1,319.66 1,798.91 1,972.07 986.56 1,108.59 1,310.74 1,630.90 1,001.53 990.54 1,393.71 1,605.85 1,790.85 1,723.85 916.54 1,108.56 767.37 2,034.01 804.47 1,677.93 2,024.98 1,745.87 946.52 1,119.59 2,225.14 2,328.13 1,162.60 1,131.54 1,586.83 2,147.00 1,324.70 1,951.94

Table S1 page 39/159

TATDEAYKDPSNLQGK VLETAEDIQER VNEVNQFAAK ADYSGMSSGSGLYAQK IKDLFPDGSISSSTK LGFDLFK NNDLSMFVLLPNDIDGLEK YYHASLEPVDFVNAADESR AALPEGLPEASR AANMHAQIK ASLEDLGWADWVLSPR TDTGVSLQTYDDLLAK SGNYPSSLSNETDR VDQETLTEMVKPSIDYVR AQFEGIVTDLIR DAGQISGLNVLR DSETGENIR KDSETGENIR LLGQFTLIGIPPAPR LYSPSQIGAFVLMK NAVITVPAYFNDSQR NTTIPTK QAVTNPNNTFYATK RYDDPEVQK SQVFSTAADGQTQVEIK STNGDTFLGGEDFDQALLR TTPSVVAFTADGER VINEPTAAALAYGLDK VLENAEGAR VQQTVQDLFGR NPPDVDGVIGEIR YDASILLWK IVQEFYDPMTPVNAR VFDSLLNLSSTLQATR ASKPLPPAPAPDEYLVSPITGEK IGEEEIQKPEEK VMQQQQQTTQQQLPQK VQAQVIQETIVPK AIKVEQATKPSFESGR GFAFVTFESPADAK IVEVLLMK LFIGGLNTETNEK VEQATKPSFESGR EALTYDGALLGDR EEVVQKEQE GSNMDFREPTEEER

Serpin B13

SPB13_HUMAN SERPINB13

44,259

100.00%

5

5

8

19.40%

Growth/differentiation factor 15

GDF15_HUMAN GDF15

34,137

100.00%

4

4

6

17.20%

LanC-like protein 2

LANC2_HUMAN LANCL2

50,838

99.50%

2

2

2

7.11%

Stress-70 protein, mitochondrial

GRP75_HUMAN HSPA9

73,663

100.00%

15

15

58

28.60%

Myelin protein zero-like protein 2

MPZL2_HUMAN MPZL2

24,466

99.50%

2

2

6

10.20%

Claudin-1

CLD1_HUMAN CLDN1

22,726

99.50%

2

2

5

14.70%

Splicing factor 3A subunit 1

SF3A1_HUMAN SF3A1

88,868

100.00%

4

4

10

8.07%

Heterogeneous nuclear ribonucleoprotein G

HNRPG_HUMAN RBMX

42,316

100.00%

5

7

19

13.00%

Eukaryotic translation initiation factor 4H

IF4H_HUMAN EIF4H

27,368

100.00%

4

5

15

23.80%

Splicing factor, arginine/serine-rich 1 SFRS1_HUMAN SFRS1

27,727

100.00%

10

11

90

44.40% DGTGVVEFVR DGYDYDGYR EAGDVCYADVYR GGPPFAFVEFEDPR

TVATPLNQVANPNSAIFGGARPR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

73.9 71.1 72.5 64.8 30.6 42.8 86.6 37.4 38.8 40.4 78.5 57.7 59.0 29.2 70.7 65.2 49.8 63.7 42.3 43.0 52.0 36.0 88.5 44.4 70.0 97.8 88.8 98.2 61.5 77.0 69.1 40.3 62.1 74.0 29.6 55.0 71.6 55.5 38.5 76.1 32.0 80.0 60.5 82.7 46.9 37.4 43.9 66.8 60.4 68.1 65.2

22.3 22.5 23.6 19.0 21.8 19.8 22.3 21.5 22.4 20.9 22.0 22.1 17.4 22.0 21.4 22.9 19.1 22.9 10.4 21.8 22.9 24.6 22.7 22.8 22.2 21.8 22.7 21.2 21.0 23.4 22.2 21.2 21.8 19.2 19.4 22.1 21.8 16.8 21.5 22.3 18.8 22.3 23.1 23.4 22.3 16.3 18.8 22.9 11.5 17.0 21.3

8 6 6 2 1 2 2 0 1 1 2 2 1 0 3 7 2 2 4 2 2 1 3 3 8 2 4 2 9 5 4 2 3 2 0 2 4 2 0 3 1 9 2 6 3 1 0 22 6 4 7

4 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 1 0 0 0 1 0 0 2 3 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,737.83 1,302.65 1,119.58 1,637.71 1,594.83 839.47 2,163.06 2,183.00 1,210.64 999.50 1,814.91 1,739.87 1,526.67 2,139.06 1,361.74 1,242.68 1,020.46 1,148.55 1,592.95 1,569.84 1,694.85 774.44 1,568.77 1,149.55 1,808.90 2,055.96 1,450.72 1,645.88 958.50 1,290.68 1,380.71 1,108.60 1,779.87 1,764.95 2,377.27 1,428.72 1,957.98 1,452.84 1,747.93 1,486.72 944.59 1,435.74 1,435.72 1,393.70 1,117.54 1,712.72 2,351.26 1,078.55 1,123.43 1,417.61 1,564.74

Table S1 page 40/159

GGPPFAFVEFEDPRDAEDAVYGR

HDHD2_HUMAN HDHD2 Haloacid dehalogenase-like hydrolase domain-containing protein PLAK_HUMAN JUP Junction plakoglobin

28,519

100.00%

2

2

4

13.10%

81,728

100.00%

10

10

55

17.00%

Cell adhesion molecule 4

CADM4_HUMAN CADM4

42,766

99.90%

2

2

9

6.44%

Alpha-galactosidase A

AGAL_HUMAN GLA

48,750

100.00%

5

5

19

13.50%

CD44 antigen

CD44_HUMAN CD44

81,535

100.00%

4

4

24

5.80%

40S ribosomal protein S25

RS25_HUMAN RPS25

13,725

99.50%

2

2

2

15.20%

Calpain-1 catalytic subunit

CAN1_HUMAN CAPN1

81,875

100.00%

9

10

50

12.30%

Serpin B8

SPB8_HUMAN SERPINB8

42,750

100.00%

5

5

12

18.40%

Cytochrome c

CYC_HUMAN CYCS

11,731

100.00%

6

7

20

49.50%

IYVGNLPPDIR KEDMTYAVR SHEGETAYIR TKDIEDVFYK VVVSGLPPSGSWQDLK DGLALGPGPFVTALEYATDTK LLLDGAPLIAIHK ALMGSPQLVAAVVR HPEAEMAQNSVR ISEDKNPDYR LAEPSQLLK LLNDEDPVVVTK LNYGIPAIVK LVQNCLWTLR NLALCPANHAPLQEAAVIPR SAIVHLINYQDDAELATR TMQNTSDLDTAR FQLEEFSPR LHQYDGSIVVIQNPAR ALLQDKDVIAINQDPLGK NFADIDDSWK QEIGGPR SILDWTSFNQER SYTIAVASLGK ALSIGFETCR ESSETPDQFMTADETR FAGVFHVEK TEAADLCK AALQELLSK LITPAVVSER APSDLYQIILK GQVVSLIR KAPSDLYQIILK LYELIITR NYLSIFR NYPATFWVNPQFK QLAGEDMEISVK RPTELLSNPQFIVDGATR YLGQDYEQLR ADFSGMSTEK GFQSLLSEVNR ISEVLDAGTVDPLTK LEESYDLEPFLR LGMIDAFDEAK LVLVNAIYFK ADLIAYLK GIIWGEDTLMEYLENPK GIIWGEDTLMEYLENPKK KTGQAPGYSYTAANK TGPNLHGLFGR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

37.0 54.8 43.4 42.9 62.2 39.5 70.3 45.4 73.5 42.3 27.4 35.7 72.9 52.9 60.4 46.1 27.0 56.2 55.8 35.9 43.7 38.2 38.7 72.2 34.2 58.0 83.6 42.3 41.4 39.3 35.6 63.3 43.3 72.3 45.5 31.5 70.7 59.1 52.0 58.2 52.9 57.5 105.0 48.0 58.0 32.0 62.3 93.6 98.9 98.8 70.8

20.5 21.6 21.1 22.0 22.2 21.0 21.8 7.0 20.1 20.4 22.0 17.5 21.3 18.1 23.1 19.4 21.8 19.9 22.2 20.4 17.5 19.7 20.7 22.1 19.6 22.6 10.4 22.9 20.9 20.0 18.6 18.9 21.0 16.7 14.6 20.5 22.6 22.4 21.2 21.4 14.0 23.3 22.2 22.9 23.2 14.0 17.4 22.5 22.0 22.6 21.7

0 17 8 6 8 5 2 2 17 2 0 1 7 16 6 0 0 2 7 0 0 2 2 7 4 6 1 8 9 1 1 12 3 12 5 1 6 2 1 2 1 3 2 2 4 4 4 4 2 2 3

3 0 0 0 4 0 0 0 0 0 1 0 0 0 0 2 1 0 0 2 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,541.17 1,256.70 1,128.54 1,162.55 1,257.64 1,668.90 2,136.09 1,373.85 1,427.80 1,384.63 1,236.59 998.59 1,341.73 1,087.65 1,302.70 2,155.14 2,029.04 1,352.61 1,152.57 1,809.96 1,951.09 1,210.54 756.40 1,495.72 1,109.62 1,153.57 1,859.76 1,033.55 907.42 972.57 1,084.64 1,260.72 871.54 1,388.82 1,020.61 912.49 1,611.80 1,335.65 2,014.07 1,284.62 1,088.46 1,249.65 1,557.84 1,510.74 1,209.58 1,179.71 906.53 2,023.97 2,136.07 1,556.77 1,168.62

Table S1 page 41/159

Superoxide dismutase [Cu-Zn]

SODC_HUMAN SOD1

15,917

100.00%

2

2

5

Amidophosphoribosyltransferase

PUR1_HUMAN PPAT

57,381

99.50%

2

2

4

26S proteasome non-ATPase regulatory subunit 9 Collagenase 3

PSMD9_HUMAN PSMD9

24,635

99.50%

2

3

5

MMP13_HUMAN MMP13

53,804

100.00%

7

7

14

TGQAPGYSYTAANK 16.90% GDGPVQGIINFEQK HVGDLGNVTADK 4.26% EVLPGEIVEISR IVLVDDSIVR 9.42% KLGQSESQGPPR SDVDLYQVR 22.70% DPGALMFPIYTYTGK ENAASSMTER IVNYTPDMTHSEVEK LDDNTLDVMK LIEEDFPGIGDKVDAVYEK SHFMLPDDDVQGIQSLYGPGDEDPNPK

UPF0424 protein C1orf128

CA128_HUMAN C1orf128

24,160

100.00%

3

3

7

GDP-fucose protein Ofucosyltransferase 1 Programmed cell death protein 5

OFUT1_HUMAN POFUT1

43,938

99.90%

2

2

3

PDCD5_HUMAN PDCD5

14,267

99.50%

2

2

2

Partner of Y14 and mago

WIBG_HUMAN WIBG

22,638

99.50%

2

2

6

Apoptosis-inducing factor 1, mitochondrial

AIFM1_HUMAN AIFM1

66,884

100.00%

4

4

10

Glia maturation factor beta

GMFB_HUMAN GMFB

16,696

99.50%

2

2

3

Lupus La protein

LA_HUMAN

46,821

100.00%

7

7

25

Platelet-activating factor acetylhydrolase IB subunit gamma Catalase

PA1B3_HUMAN PAFAH1B3

25,716

100.00%

2

2

11

CATA_HUMAN CAT

59,739

100.00%

4

4

8

Olfactomedin-like protein 2A

OLM2A_HUMAN OLFML2A

73,037

100.00%

4

4

51

Gelsolin

GELS_HUMAN GSN

85,680

100.00%

28

41

685

SSB

TLLFSGNQVWR 12.80% DLTGELEYATK GLAYGLYLR VFYIGLR 6.70% FGNQADHFLGSLAFAK VISLEDFMEK 19.20% AVENYLIQMAR NSILAQVLDQSAR 14.20% AAPTAASDQPDSAATTEK IQAGEVSQPSK 8.48% ALGTEVIQLFPEK ELWFSDDPNVTK SATEQSGTGIR VMPNAIVQSVGVSSGK 23.90% LVVLDEELEGISPDELKDELPER NTEDLTEEWLR 19.90% EVTWEVLEGEVEK GSIFVVFDSIESAK IIEDQQESLNK LDEGWVPLEIMIK NKEVTWEVLEGEVEK QKLEEDAEMK SPSKPLPEVTDEYKNDVK 7.79% AIVQLVNER VVVLGLLPR 11.40% ADVLTTGAGNPVGDKLNVITVGPR AFYVNVLNEEQR FNTANDDNVTQVR LSQEDPDYGIR 6.75% LDPGDLSVHR LGLQLLQK SNSAEPNSAEQDEAEPR VFGDLDQVR 43.20% AGALNSNDAFVLK AGKEPGLQIWR AQPVQVAEGSEPDGFWEALGGK

AVEVLPK DPDQTDGLGLSYLSSHIANVER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

56.6 69.4 71.4 61.1 44.3 39.4 55.9 48.5 30.0 65.2 34.8 27.2 54.0 56.5 30.3 45.7 39.8 48.4 38.8 40.3 69.2 139.0 44.1 38.2 33.4 59.8 49.9 64.2 63.8 57.3 68.4 70.6 44.4 27.8 39.0 39.6 45.2 71.8 50.0 71.1 72.0 40.2 58.1 54.5 136.0 56.9 84.6 57.0 117.0 56.8 121.0

21.2 23.0 22.4 20.1 21.2 21.9 21.7 23.1 17.6 25.3 22.9 21.8 18.5 22.8 22.6 19.0 19.7 22.7 22.8 22.7 21.7 20.4 22.0 20.1 21.2 23.1 22.8 21.4 21.5 22.4 21.6 23.6 21.8 22.4 21.7 22.0 20.0 3.0 17.2 22.3 22.4 22.1 22.3 13.0 15.4 24.0 23.0 19.8 21.4 14.5 21.7

4 3 2 2 2 2 2 4 1 2 1 0 0 4 1 4 2 0 1 1 1 4 2 3 1 4 2 0 1 4 8 6 2 0 0 0 2 9 0 2 2 2 4 4 39 4 66 3 53 20 2

0 0 0 0 0 1 0 0 0 0 0 1 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 1 2 2 0 0 2 0 0 0 0 0 0 0 0 26 5 0 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,428.68 1,501.77 1,225.62 1,340.74 1,128.66 1,283.67 1,094.55 1,689.82 1,095.47 1,778.83 1,163.56 2,137.07 2,987.34 1,320.71 1,239.61 1,025.58 867.51 1,722.86 1,210.60 1,307.68 1,414.77 1,731.80 1,143.60 1,444.81 1,450.69 1,106.54 1,588.84 2,637.35 1,405.66 1,546.76 1,498.78 1,316.67 1,542.82 1,788.90 1,236.58 2,046.04 1,041.61 965.65 2,364.29 1,481.74 1,493.70 1,292.61 1,108.58 912.59 1,830.77 1,048.54 1,319.70 1,254.70 2,272.09 755.47 2,387.15

Table S1 page 42/159

DSQEEEKTEALTSAK EPGLQIWR EVQGFESATFLGYFK GASQAGAPQGR GGVASGFK HVVPNEVVVQR KGGVASGFK LKATQVSK NWRDPDQTDGLGLSYLSSHIANVER

QTQVSVLPEGGETPLFK RTPITVVK SEDCFILDHGK SEDCFILDHGKDGK TASDFITK TGAQELLR TPITVVK TPSAAYLWVGTGASEAEK VHVSEEGTEPEAMLQVLGPKPALPAGTEDTAK VHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANR

VPEARPNSMVVEHPEFLK VPFDAATLHTSTAMAAQHGMDDDGTGQK

VSNGAGTMSVSLVADENPFAQGALK

Peptidyl-prolyl cis-trans isomerase A PPIA_HUMAN PPIA

17,995

100.00%

13

17

257

YIETDPANR 72.70% ALSTGEK EGMNIVEAMER FEDENFILK HTGPGILSMANAGPNTNGSQFFICTAK

GRB2_HUMAN GRB2 Growth factor receptor-bound protein 2 Transcription intermediary factor 1- TIF1B_HUMAN TRIM28 beta

25,189

100.00%

2

2

3

11.10%

88,531

100.00%

3

3

9

6.23%

26S proteasome non-ATPase regulatory subunit 3

PSMD3_HUMAN PSMD3

60,962

100.00%

6

6

8

14.40%

Proprotein convertase subtilisin/kexin type 9

PCSK9_HUMAN PCSK9

74,353

100.00%

19

26

261

35.00%

IIPGFMCQGGDFTR MVNPTVFFDIAVDGEPLGR SIYGEKFEDENFILK TEWLDGK TEWLDGKHVVFGK VKEGMNIVEAMER VNPTVFFDIAVDGEPLGR VSFELFADK VSFELFADKVPK ATADDELSFK ESESAPGDFSLSVK IVAERPGTNSTGPAPMAPPR LDLDLTADSQPPVFK LSPPYSSPQEFAQDVGR AVQGFFTSNNATR FNQVLDQFGEK LQLDSPEDAEFIVAK SLMPYFLLTQAVR SVFPEQANNNEWAR TAAAAAEHSQR AGVVLVTAAGNFR AHNAFGGEGVYAIAR CAPDEELLSCSSFSR DVINEAWFPEDQR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

101.0 37.9 110.0 69.2 43.4 57.0 47.9 38.1 72.8 91.1 31.0 65.6 27.1 46.1 74.2 35.2 122.0 70.1 48.7 61.4 65.3 113.0 48.1 35.6 58.7 56.8 76.5 88.7 138.0 82.9 41.3 29.4 86.5 106.0 65.3 66.9 30.5 49.4 53.6 69.6 84.4 90.8 49.1 39.1 30.1 38.8 61.7 48.4 79.6 94.7 74.4

22.8 20.8 22.3 20.8 22.5 20.5 21.0 17.8 21.2 21.2 17.0 19.6 19.6 20.8 23.7 14.9 22.4 19.6 19.2 21.9 18.5 21.9 23.0 26.1 21.3 21.7 21.5 22.0 22.6 22.6 23.0 22.3 22.7 21.5 21.4 20.3 22.4 22.1 22.5 22.0 23.1 22.2 22.3 22.9 19.8 21.0 21.1 19.7 22.5 16.8 21.0

38 3 95 11 7 20 2 2 0 61 2 3 0 2 18 2 116 0 0 0 0 4 9 1 15 6 0 7 13 37 14 0 21 38 30 19 1 2 0 2 3 1 1 2 1 1 2 8 9 2 22

18 0 0 0 0 11 0 0 6 1 0 1 1 0 0 0 1 5 0 10 20 7 0 0 0 0 4 0 0 4 0 1 12 22 0 13 0 0 4 0 0 0 0 0 0 0 0 0 12 0 0

0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 2 5 1 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,665.78 998.54 1,722.84 999.50 722.38 1,275.72 850.48 874.54 2,843.37 1,829.97 913.58 1,320.59 1,620.73 882.46 887.50 757.48 1,837.90 3,317.66 3,957.95 2,095.06 2,889.28 2,479.21 1,078.52 705.38 1,278.58 1,154.57 2,791.33 1,598.75 2,077.04 1,831.91 848.42 1,515.80 1,505.75 1,946.00 1,055.54 1,379.76 1,096.52 1,452.69 2,035.04 1,658.86 1,877.90 1,412.69 1,324.65 1,674.86 1,538.84 1,661.77 1,112.54 1,274.72 1,532.76 1,757.75 1,618.75

Table S1 page 43/159

GTVSGTLIGLEFIR HLAQASQELQ ILHVFHGLLPGFLVK LPGTYVVVLK LPGTYVVVLKEETHLSQSER LQAQAAR MATAIAR MSGDLLELALK RLQAQAAR SEEDGLAEAPEHGTTATFHR SQLVQPVGPLVVLLPLAGGYSR TVWSAHSGPTR VLNAACQR VLTPNLVAALPPSTHGAGWQLFCR

Proteasome subunit alpha type-4

PSA4_HUMAN PSMA4

29,467

100.00%

9

10

49

VMVTDFENVPEEDGTR 36.80% ATCIGNNSAAAVSMLK EGEMTLK LLDEVFFSEK LNEDMACSVAGITSDANVLTNELR

Deoxyribonuclease-2-alpha

DNS2A_HUMAN DNASE2

39,563

99.90%

2

2

5

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

DDAH2_HUMAN DDAH2

29,626

100.00%

6

7

12

LSAEKVEIATLTR QAYTQFGGK SALALAIK TTIFSPEGR VEIATLTR 6.11% ALINSPEGAVGR YLDESSGGWR 33.70% DFAVSTVPVSGPSHLR GAEIVADTFR GGGDLPNSQEALQK GVPESLASGEGAGAGLPALDLAK

Peptidyl-prolyl cis-trans isomerase B PPIB_HUMAN PPIB

Beta-1,3-Nacetylglucosaminyltransferase Thioredoxin

23,725

100.00%

13

17

92

LFNG_HUMAN LFNG

41,756

99.90%

2

3

11

THIO_HUMAN TXN

11,719

100.00%

6

6

22

IVEIGDENATLDGTDVLFTGR TVVAGSSDAAQK 54.60% DFMIQGGDFTR DKPLKDVIIADCGK DTNGSQFFITTVK FPDENFK HYGPGWVSMANAGK IEVEKPFAIAK IEVEKPFAIAKE IGDEDVGR SIYGERFPDENFK TVDNFVALATGEK VIFGLFGK VIKDFMIQGGDFTR VLEGMEVVR 5.28% GPFSVEADPSR LLASYPHTR 42.90% EKLEATINELV LEATINELV MIKPFFHSLSEK TAFQEALDAAGDK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

62.4 52.4 46.2 38.2 34.7 45.8 44.8 88.1 44.4 79.3 108.0 59.0 43.5 29.5 108.0 80.9 31.1 75.0 128.0 77.6 34.3 62.0 42.0 54.7 64.5 76.3 50.8 51.6 52.2 102.0 129.0 64.5 51.0 68.5 96.1 32.9 75.9 42.3 70.6 50.4 53.6 98.9 52.6 91.2 56.4 67.1 45.0 49.1 35.8 65.2 99.2

19.4 22.4 7.8 12.8 19.6 19.4 24.2 23.0 20.5 20.5 10.4 22.3 24.2 19.4 20.8 22.7 21.0 22.6 21.5 18.5 20.8 17.9 23.3 20.5 21.4 21.4 21.5 23.6 22.5 21.0 22.6 23.1 19.3 20.9 22.0 20.6 21.4 17.3 20.4 20.2 22.0 22.8 18.7 22.4 23.1 22.1 22.1 22.7 23.6 22.6 22.6

22 7 0 3 0 2 6 12 1 2 68 8 3 0 25 4 1 15 2 2 1 9 8 4 3 2 2 2 2 2 2 1 5 2 4 2 4 2 7 2 2 20 13 4 9 5 4 8 1 4 4

2 0 7 0 4 0 0 0 0 2 19 0 0 3 0 0 0 0 0 3 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 4 0 4 0 0 0 0 7 0 0 2 0 0 0 0

0 0 9 0 1 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,462.83 1,124.57 1,690.02 1,088.67 2,285.21 757.43 749.40 1,189.65 913.53 2,154.97 2,263.32 1,198.60 931.48 2,605.37 1,837.83 1,623.78 823.39 1,226.63 2,609.22 1,430.82 999.49 786.51 1,007.52 902.53 1,183.64 1,169.52 1,668.87 1,078.55 1,413.70 2,080.09 2,235.11 1,133.58 1,286.58 1,571.85 1,457.73 896.42 1,474.69 1,244.73 1,373.77 860.41 1,601.76 1,364.71 880.53 1,642.83 1,031.56 1,161.55 1,057.58 1,258.69 1,001.55 1,479.77 1,336.64

Table S1 page 44/159

TNPO1_HUMAN TNPO1

102,341

100.00%

3

3

3

4.68%

Serine/threonine-protein phosphatase PPP5_HUMAN PPP5C 5

56,862

100.00%

9

9

16

23.80%

Small nuclear ribonucleoprotein Sm SMD1_HUMAN SNRPD1 D1 Guanine nucleotide-binding protein GBG12_HUMAN GNG12 G(I)/G(S)/G(O) subunit gamma-12 PAPL_HUMAN PAPL Iron/zinc purple acid phosphataselike protein

13,264

99.50%

2

3

8

27.70%

7,989

99.50%

2

2

2

37.50%

50,462

100.00%

3

3

6

10.00%

Transportin-1

Ephrin-B1

EFNB1_HUMAN EFNB1

37,989

100.00%

6

8

38

24.60%

L-lactate dehydrogenase A chain

LDHA_HUMAN LDHA

36,671

100.00%

14

16

150

38.60%

Nidogen-2

NID2_HUMAN NID2

151,235

100.00%

19

20

147

17.10%

VGEFSGANK VGEFSGANKEK ESQSPDTTIQR GDVEEDETIPDSEQDIRPR QSSFALLGDLTK AALRDYETVVK AASNMALGK AEGYEVAHGGR AFLEENNLDYIIR AIAGDEHKR AIELDKK FYSQAIELNPSNAIYYGNR GNHETDNMNQIYGFEGEVK SVVDSLDIESMTIEDEYSGPK NREPVQLETLSIR YFILPDSLPLDTLLVDVEPK SDPLLIGIPTSENPFK TASTNNIAQAR AQGTFVPFVDGGILR LAVFGDLGADNPK SEVQFGLQPSGPLPLR AEAGRPYEYYK FQEFSPNYMGLEFK GGSGTAGTEPSDIIIPLR GSLGDSDGKHETVNQEEK IGDKLDIICPR NLEPVSWSSLNPK DLADELALVDVIEDK DQLIYNLLK DQLIYNLLKEEQTPQNK DYNVTANSK FIIPNVVK GEMMDLQHGSLFLR KSADTLWGIQK LNLVQR LVIITAGAR NVNIFK QVVESAYEVIK SADTLWGIQK VIGSGCNLDSAR VTLTSEEEAR AGLELGAEPETIVNSGLISPEGLAIDHIR

AIAVDPIR DGVVSVNK EDTSPAVLGLAAR ELYHYSDSTVTSTSSR ESYNVQLQLPAR GEADDLKSEGPYFSLTSTEQSVK

GNLYWTDWNR HAQAQYAYPGAR HPSFPTTQQLNVDR

95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

56.0 37.8 30.1 40.7 60.1 37.3 39.6 41.2 89.2 38.5 39.4 115.0 41.3 118.0 53.8 87.8 30.5 49.0 73.9 45.9 54.2 30.5 73.7 47.0 43.5 42.1 89.0 106.0 64.7 76.1 62.2 36.9 43.2 35.2 48.6 73.5 31.4 56.5 64.5 73.9 66.1 48.4 31.6 38.5 73.1 72.8 57.1 37.0 36.9 54.1 53.7

22.5 23.5 22.2 20.5 21.9 20.8 23.4 19.8 21.9 21.0 22.6 21.8 17.1 19.8 20.0 17.0 21.1 23.5 21.1 23.4 19.7 21.9 21.1 21.8 20.0 21.1 22.7 21.3 20.4 21.9 20.6 17.9 22.0 21.7 18.8 17.0 22.0 21.8 23.0 21.7 23.7 17.7 18.7 24.1 21.3 20.6 22.5 20.3 21.4 23.2 22.5

3 2 1 0 1 1 2 1 4 1 2 2 0 2 2 4 1 1 3 1 2 1 8 2 1 1 12 25 6 2 2 3 4 2 25 22 1 4 11 3 34 0 1 2 16 4 9 0 4 14 0

0 0 0 1 0 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 6 7 0 0 0 2 0 0 4 0 0 0 0 0 0 0 0 2 0 0 0 1 0 2 0 0 16

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

908.45 1,165.59 1,261.60 2,200.00 1,279.69 1,264.69 878.44 1,145.53 1,609.82 996.52 816.48 2,220.07 2,197.95 2,330.06 1,554.86 2,287.25 1,727.92 1,146.59 1,576.85 1,316.69 1,724.93 1,346.64 1,752.79 1,740.91 1,929.88 1,299.71 1,470.76 1,657.85 1,119.64 2,074.08 1,011.47 929.58 1,649.78 1,246.68 742.46 913.58 734.42 1,264.68 1,118.58 1,248.60 1,134.56 2,971.57 854.51 817.44 1,299.69 1,832.83 1,417.74 2,488.17 1,324.61 1,332.64 1,639.82

Table S1 page 45/159

Nucleophosmin

NPM_HUMAN NPM1

32,557

100.00%

9

10

143

HSGQFTDEYLPEQR IETSSLDGENRR ITQTAEGLDPENYLSIK KVLFYTDLVNPR LANPLHFYEAR MVYWTDVAGR SEGPYFSLTSTEQSVK VFALYNDEER VLFYTDLVNPR VLYREDTSPAVLGLAAR 38.80% GPSSVEDIK LLSISGK MQASIEK MSVQPTVSLGGFEITPPVVLR MTDQEAIQDLWQWR SKGQESFK TVSLGAGAKDELHIVEAEAMNYEGSPIK

Collagen alpha-6(IV) chain

CO4A6_HUMAN COL4A6

163,794

100.00%

3

3

7

2.25%

Tropomodulin-3

TMOD3_HUMAN TMOD3

39,578

99.90%

2

2

6

7.10%

Aspartyl aminopeptidase

DNPEP_HUMAN DNPEP

52,411

100.00%

3

3

4

4.84%

Xaa-Pro dipeptidase

PEPD_HUMAN PEPD

54,530

100.00%

6

6

29

14.40%

Filamin-B

FLNB_HUMAN FLNB

278,141

100.00%

83

99

1267

41.70%

VDNDENEHQLSLR VTLATLK GDSGSQGFR GNPGPVGIPSPR GPMGSEGVQGPPGQQGK FGYQFTQQGPR SNDPVATAFAEMLK VKVPLQDLMVR VPLQDLMVR YASNAVSEALIR AVYEAVLR FEVNNTILHPEIVECR KNPAVQAGSIVVLQGGEETQR STLFVPR TDMELEVLR VPLALFALNR AAGSGELGVTMK ADIEMPFDPSK AEVSIQNNK AGGPGLER AGLAPLEVR AGPGTLSVTIEGPSK AHGPGLEGGLVGKPAEFTIDTK APLNVQFNSPLPGDAVK APSVATVGSICDLNLK AWGPGLHGGIVGR CLATGPGIASTVK DAGEGLLAVQITDQEGKPK DAGYGGISLAVEGPSK DGTYAVTYIPDK DGTYAVTYVPLTAGMYTLTMK DLAEDAPWK DLAEDAPWKK DLDIIDNYDYSHTVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

69.7 29.0 121.0 79.4 51.2 54.0 96.3 57.1 64.7 35.6 67.2 44.5 40.3 126.0 86.8 34.3 69.0 89.0 37.8 48.9 39.2 79.3 50.3 63.4 30.4 37.8 46.1 33.9 43.4 61.1 33.8 63.4 87.8 70.7 73.7 41.1 79.5 49.7 70.1 36.9 79.2 106.0 48.6 60.6 65.0 55.8 41.7 40.9 31.6 40.9 81.1

21.9 21.8 22.0 18.3 23.2 22.0 21.6 21.2 20.8 19.4 21.7 22.0 22.8 19.2 24.6 21.5 21.1 21.7 15.1 19.3 22.8 21.0 22.4 23.2 19.1 22.7 22.9 21.0 21.7 19.0 20.5 23.7 16.9 23.0 19.9 22.9 20.7 17.9 22.1 19.0 21.3 21.6 22.7 23.6 21.6 23.0 21.7 21.3 20.5 22.5 21.0

3 0 29 1 4 7 6 17 10 1 31 1 7 49 26 1 0 15 5 1 2 4 2 4 0 2 1 1 0 0 3 3 18 24 30 5 30 15 18 0 35 2 2 7 5 3 3 1 1 2 18

0 2 0 0 0 0 0 0 0 0 0 0 0 6 0 0 2 0 0 0 0 0 0 0 1 0 0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,706.78 1,376.68 1,891.97 1,464.82 1,330.69 1,197.57 1,759.84 1,255.60 1,336.73 1,831.01 931.47 717.45 822.40 2,243.21 1,835.84 910.46 2,929.46 1,568.73 745.48 910.40 1,147.62 1,626.76 1,328.64 1,493.73 1,313.76 1,086.60 1,293.68 920.52 1,969.98 2,181.16 819.47 1,121.55 1,113.68 1,136.56 1,265.57 1,002.52 756.40 925.55 1,413.76 2,194.15 1,766.94 1,644.86 1,276.69 1,274.68 1,969.02 1,520.76 1,342.65 2,328.11 1,044.50 1,172.60 1,810.85

Table S1 page 46/159

EAFTNKPNVFTVVTR EAGAGGLSIAVEGPSK EATTDFTVDSRPLTQVGGDHIK FADEHVPGSPFTVK FNDEHIPESPYLVPVIAPSDDAR FNGSHVVGSPFK FVPQEMGVHTVSVK GAGIGGLGITVEGPSESK GEAGVPAEFSIWTR GIEPTGNMVK GLEELVK GLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVK

GQHVTGSPFQFTVGPLGEGGAHK

HVGNQQYNVTYVVK IAGPGLGSGVR IFAQDGEGQR IFFAGDTIPK IGNLQTDLSDGLR IKVFGPGIEGK IPEINSSDMSAHVTSPSGR IPYLPITNFNQNWQDGK IQQNTFTR KGEITGEVHMPSGK LDVTILSPSR LDVTILSPSRK LIALLEVLSQK LKPGAPLKPK LLGWIQNK LNGLENR LPNNHIGISFIPR LTVMSLQESGLK LVSPGSANETSSILVESVTR NTVELLVEDK NTVELLVEDKGNQVYR SPFEVQVGPEAGMQK SPFEVSVDK SPFTVGVAAPLDLSK TATPEIVDNKDGTVTVR TFEMSDFIVDTR TGEEVGFVVDAK TYSVEYLPK VDPSHDASK VEVGKDQEFTVDTR VFGPGIEGK VKAEGPGLSK VKVDPSHDASK VKVEPAVDTSR VLFASQEIPASPFR VLQSFTVDSSK VLSEDEEDVDFDIIHNANDTFTVK

VMYTPMAPGNYLISVK

95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

63.6 80.8 52.5 41.6 36.7 26.4 65.5 85.3 75.9 37.8 31.9 90.7 43.6 52.0 79.6 63.3 59.8 72.4 46.6 98.2 82.1 42.6 40.4 77.0 32.4 65.7 32.5 65.3 44.8 44.3 58.7 129.0 32.6 33.3 86.5 41.2 101.0 79.9 92.5 46.2 41.8 35.2 87.8 37.5 34.6 27.5 45.3 85.8 69.1 31.5 74.2

20.9 22.5 21.7 22.1 21.4 22.9 23.6 22.0 23.6 22.4 21.8 19.2 21.8 23.3 18.8 22.9 21.2 22.5 18.6 22.0 22.6 22.3 21.8 22.7 18.7 13.4 0.0 22.2 21.5 17.7 22.5 21.3 24.0 21.8 22.1 21.8 21.5 20.9 21.1 22.6 22.3 20.1 22.9 22.7 18.6 21.9 22.3 22.5 22.5 20.5 22.4

11 7 0 3 1 0 6 25 17 5 1 0 0 2 29 52 55 17 0 6 31 12 1 17 0 17 0 37 2 0 8 35 1 0 36 7 57 7 19 15 3 1 12 2 4 0 3 38 6 0 21

43 0 12 6 3 1 0 0 0 0 0 10 4 0 0 0 0 0 9 20 0 0 4 0 1 0 3 0 0 10 0 3 0 3 0 0 0 2 0 0 0 0 13 0 0 1 14 0 0 1 0

0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,722.92 1,442.75 2,387.18 1,530.76 2,581.26 1,275.65 1,573.80 1,628.85 1,519.75 1,061.53 787.46 3,505.68 2,308.15 1,648.84 983.56 1,120.54 1,108.60 1,401.73 1,144.67 1,984.94 2,048.02 1,007.53 1,485.74 1,100.63 1,228.73 1,226.77 1,048.69 971.57 815.44 1,477.83 1,321.70 2,046.07 1,159.62 1,876.98 1,603.78 1,007.51 1,501.83 1,815.95 1,460.67 1,250.63 1,099.57 955.45 1,622.80 903.49 985.57 1,182.61 1,200.66 1,561.84 1,210.63 2,765.28 1,799.91

Table S1 page 47/159

VNIGQGSHPQK VNQPASFAIR VPVKDVVDPSK VQAQGPGLK VSYFPTVPGVYIVSTK VTASGPGLSSYGVPASLPVDFAIDAR

VTEAEIVPMGK VVASGPGLEHGK VVPCLVTPVTGR YADEEIPR YGGELVPHFPAR YGGPNHIVGSPFK YMIGVTYGGDDIPLSPYR YTPTQQGNMQVLVTYGGDPIPK

Echinoderm microtubule-associated EMAL2_HUMAN EML2 protein-like 2

70,659

100.00%

5

5

11

Heterogeneous nuclear ribonucleoprotein D0

HNRPD_HUMAN HNRNPD

38,417

100.00%

8

10

116

Single-stranded DNA-binding protein, mitochondrial Endoplasmic reticulum resident protein 44

SSBP_HUMAN SSBP1

17,242

99.50%

2

2

5

ERP44_HUMAN ERP44

46,955

100.00%

3

3

6

Ubiquitin-conjugating enzyme E2 N UBE2N_HUMAN UBE2N

17,121

100.00%

3

3

5

Transcriptional activator protein Pur- PURA_HUMAN PURA alpha CYTN_HUMAN CST1 Cystatin-SN

34,893

100.00%

2

2

3

16,344

99.50%

2

2

3

8.63% DGTLVSGGGR IIEDPAR LQEVEVPEDFGPVR QITSADAVR TVAEGHGDTLYVGTTR 26.50% ESESVDKVMDQK EYFGGFGEVESIELPMDNK FGEVVDCTLK GFGFVLFK IDASKNEEDEGHSNSSPR IFVGGLSPDTPEEK MFIGGLSWDTTK MFIGGLSWDTTKK 20.30% NPVTIFSLATNEMWR SGDSEVYQLGDVSQK 7.88% DLAEITTLDR SDPIQEIR TPADCPVIAIDSFR 23.70% LELFLPEEYPMAAPK LLAEPVPGIK TNEAQAIETAR 11.20% IAEVGAGGNK LIDDYGVEEEPAELPEGTSLTVDNKR

Ceruloplasmin

CERU_HUMAN CP

122,190

100.00%

9

9

29

Beta-2-microglobulin

B2MG_HUMAN B2M

13,697

100.00%

5

10

224

24.80% IIPGGIYNADLNDEWVQR QQTVGGVNYFFDVEVGR 11.50% ALYLQYTDETFR DIASGLIGPLIICK DIFTGLIGPMK EYTDASFTNR GAYPLSIEPIGVR MFTTAPDQVDKEDEDFQESNK NNEGTYYSPNYNPQSR QSEDSTFYLGER VNKDDEEFIESNK 42.90% IEKVEHSDLSFSK IQVYSR SNFLNCYVSGFHPSDIEVDLLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

44.6 70.9 64.6 52.9 58.5 52.0 77.4 78.2 45.7 52.8 41.9 59.3 62.4 92.5 61.7 35.8 85.5 34.8 74.3 43.1 73.6 55.7 40.5 68.2 91.8 71.1 32.9 81.9 100.0 50.1 31.9 37.0 32.4 34.7 54.5 46.8 67.1 89.7 33.1 66.1 53.3 33.7 51.8 56.2 38.4 71.4 69.1 88.5 92.9 39.4 44.9

22.2 23.5 19.4 17.6 20.3 20.3 23.3 22.5 19.3 22.1 22.1 22.3 21.0 21.2 23.9 19.7 22.1 24.0 22.4 21.8 20.2 22.7 22.9 18.9 23.0 22.4 22.1 22.4 21.4 23.8 20.8 22.8 22.4 11.8 23.2 21.6 21.3 22.4 21.6 23.4 19.3 23.0 17.0 22.0 15.7 17.5 20.2 21.3 23.0 21.9 21.4

13 25 17 13 30 6 24 22 6 7 3 4 6 9 3 1 4 1 2 4 7 13 13 3 45 6 2 3 2 4 1 1 1 2 2 2 0 2 1 2 2 1 3 9 0 4 2 4 5 12 7

13 0 0 0 0 0 0 21 0 0 30 2 0 0 0 0 0 0 0 2 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 0 0 0 3 0 37

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,164.61 1,102.60 1,182.67 897.52 1,756.95 2,547.31 1,173.62 1,150.62 1,297.73 992.47 1,342.69 1,372.70 2,032.97 2,423.19 918.46 813.45 1,613.82 960.51 1,676.82 1,394.65 2,176.98 1,167.57 914.51 1,971.86 1,488.76 1,355.67 1,499.76 1,778.89 1,611.75 1,146.60 957.50 1,561.77 1,763.89 1,036.64 1,203.60 915.49 2,889.40 2,073.04 1,914.94 1,519.74 1,469.84 1,207.64 1,203.53 1,371.76 2,490.06 1,903.82 1,431.64 1,566.73 1,518.78 765.43 2,554.23

Table S1 page 48/159

Adenosylhomocysteinase

SAHH_HUMAN AHCY

47,699

100.00%

18

24

142

39.60%

Aspartyl-tRNA synthetase, cytoplasmic

SYDC_HUMAN DARS

57,119

100.00%

5

5

10

14.20%

Nuclear migration protein nudC

NUDC_HUMAN NUDC

38,226

100.00%

8

8

20

27.50%

Procollagen-lysine,2-oxoglutarate 5- PLOD3_HUMAN PLOD3 dioxygenase 3

84,769

100.00%

16

16

77

27.00%

269,747

100.00%

6

6

11

3.19%

Talin-1

TLN1_HUMAN TLN1

VEHSDLSFSK VNHVTLSQPK AGIPVYAWK ALDIAENEMPGLMR ATDVMIAGK DGPLNMILDDGGDLTNLIHTK ESLIDGIK ESLIDGIKR GISEETTTGVHNLYK IILLAEGR KALDIAENEMPGLMR KLDEAVAEAHLGK LDEAVAEAHLGK VADIGLAAWGR VAVVAGYGDVGK VNIKPQVDR VPAINVNDSVTK WLNENAVEK YPQLLPGIR YPVGVHFLPK ATVNQDTR EAGVEMGDEDDLSTPNEK FGAPPHAGGGIGLER IYVISLAEPR LPLQLDDAVRPEAEGEEEGR ELTDEEAER FMDQHPEMDFSK GQPAIIDGELYNEVK LKPNLGNGADLPNYR LSDLDSETR LVSSDPEINTK SETSGPQIK SMGLPTSDEQK AVMNFVVR DVFSGSDTDPDMAFCK IFQNLNGALDEVVLK KFVQSGSR LAGGYENVPTVDIHMK LLLLDYPPDR LSLNLDHK LVGPEEALSPGEAR LYLDPGLR NVAYDTLPIVVHGNGPTK QVGYEDQWLQLLR SEDYVELVQR TLGLGEEWR TYVGPMTESLFPGYHTK VGVWNVPYISQAYVIR YKDDDDDQLFYTR AVAEQIPLLVQGVR GLAGAVSELLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

60.7 59.6 42.1 77.5 35.1 111.0 41.5 40.9 80.5 41.5 71.3 91.3 59.9 93.8 73.9 33.1 76.6 50.6 51.3 40.6 34.7 40.6 44.9 52.1 36.1 55.5 44.4 75.5 27.0 36.0 61.6 48.3 34.9 71.5 51.7 124.0 38.1 38.5 56.1 31.7 95.0 53.6 69.0 55.4 70.9 55.4 50.8 59.7 75.3 39.6 46.0

23.1 20.3 22.9 22.4 24.0 22.6 23.6 20.9 23.2 16.3 22.1 21.4 22.1 22.3 22.7 18.7 22.2 22.6 20.4 21.0 23.1 14.9 22.3 19.7 22.4 19.2 12.3 22.0 21.2 22.4 23.9 23.8 21.0 22.8 14.1 19.6 21.1 22.1 22.3 17.4 21.9 21.7 21.0 22.9 22.2 25.1 22.2 19.3 19.9 14.5 21.2

30 46 1 11 1 4 1 3 7 6 2 2 2 13 4 1 15 7 17 2 3 1 0 2 0 6 2 2 0 2 3 1 3 4 1 5 1 0 17 1 13 4 3 5 6 4 1 5 1 1 4

17 58 0 0 0 29 0 0 1 0 4 3 2 0 0 0 0 0 0 4 0 0 2 0 2 0 0 0 1 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,148.56 1,122.63 1,004.56 1,575.75 905.48 2,268.12 874.49 1,030.59 1,648.82 884.56 1,719.84 1,380.75 1,252.65 1,128.62 1,134.62 1,068.62 1,256.69 1,102.55 1,056.62 1,156.65 904.45 1,951.81 1,435.74 1,160.67 2,223.09 1,091.49 1,543.62 1,645.84 1,641.87 1,035.50 1,202.63 946.48 1,208.55 935.51 1,791.72 1,672.93 908.50 1,743.87 1,214.68 939.53 1,424.74 946.54 1,895.00 1,647.85 1,237.61 1,060.54 1,927.93 1,864.01 1,693.73 1,492.89 1,085.63

Table S1 page 49/159

ILAQATSDLVNAIK LNEAAAGLNQAATELVQASR NLGTALAELR VLVQNAAGSQEK ESEDFIVEQYK GVLLMLFGGVPK IQETQAELPR ISGQVVR SELVNWYLK TSILAAANPISGHYDR TANEGGSLLYEQLGYK YELPLVIQALTNIEDK ALESSIAPIVIFASNR AVLLAGPPGTGK GLGLDESGLAK GTEDITSPHGIPLDLLDR LDPSIFESLQK QAASGLVGQENAR YSVQLLTPANLLAK MTELETAMGMIIDVFSR YSGSEGSTQTLTK APVDITGQFEK DNILPELGVR FEDHEGLPTVVK IQHAVQLATEPLEK WGEEEAELNK LAEMPADSGYPAYLGAR TALVANTSNMPVAAR ATAPQTQHVSPMR FYEQMNGPVAGASR GVVQELQQAISK IASLEVENQSLR KPALVAK LVPVGYGIR SIQLDGLVWGASK

DNA replication licensing factor MCM6

MCM6_HUMAN MCM6

92,873

100.00%

6

6

8

7.92%

Sodium-coupled neutral amino acid transporter 2 RuvB-like 1

S38A2_HUMAN SLC38A2

56,011

99.50%

2

2

4

6.32%

RUVB1_HUMAN RUVBL1

50,211

100.00%

7

8

22

20.80%

Protein S100-P

S100P_HUMAN S100P

10,382

99.50%

2

2

10

31.60%

Cysteinyl-tRNA synthetase, cytoplasmic

SYCC_HUMAN CARS

85,458

100.00%

5

5

8

7.62%

V-type proton ATPase catalytic subunit A Elongation factor 1-delta

VATA_HUMAN ATP6V1A

68,287

100.00%

2

2

4

5.19%

EF1D_HUMAN EEF1D

31,104

100.00%

8

10

63

37.00%

14-3-3 protein eta

1433F_HUMAN YWHAH

28,202

100.00%

9

10

41

58.90% AVTELNEPLSNEDR AVTELNEPLSNEDRNLLSVAYK DNLTLWTSDQQDEEAGEGN DSTLIMQLLR ELETVCNDVLSLLDK KNSVVEASEAAYK LAEQAER MKGDYYR NLLSVAYK NLLSVAYKNVVGAR NSVVEASEAAYK QAFDDAIAELDTLNEDSYK VISSIEQK YDDMASAMK YLAEVASGEKK

SLAGSSGPGASSGTSGDHGELVVR

95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

49.6 84.8 47.1 40.0 32.0 30.0 61.6 46.3 38.6 26.2 107.0 96.1 71.9 33.0 45.4 39.5 50.7 57.9 55.1 77.8 97.0 39.0 32.9 31.5 39.9 45.6 50.9 93.9 44.4 90.3 79.0 90.1 39.0 47.2 82.6 108.0 86.6 32.5 32.5 79.3 96.4 53.8 59.4 42.7 51.4 79.1 71.3 113.0 65.9 53.8 46.7

17.9 20.8 21.6 22.2 21.2 18.4 22.3 23.8 22.4 22.1 22.3 19.9 19.8 16.7 23.1 22.3 23.2 22.1 16.2 20.4 21.8 23.1 20.8 21.8 20.2 20.2 21.8 23.3 23.4 20.5 20.9 22.1 12.0 19.5 22.0 21.3 22.5 20.8 15.6 21.3 22.6 22.5 21.6 19.2 19.1 17.7 22.3 21.6 22.9 9.5 21.2

2 1 2 1 1 1 2 1 2 0 2 2 6 1 1 0 2 3 2 4 6 2 1 0 0 2 2 2 7 9 13 10 1 4 8 1 4 0 1 113 6 2 36 6 49 4 7 4 27 9 4

0 0 0 0 0 0 0 0 0 1 0 0 3 0 0 4 0 0 0 0 0 0 0 2 1 0 0 0 2 0 0 0 0 0 0 8 0 3 0 0 0 0 0 0 0 2 0 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,456.84 2,027.05 1,057.60 1,243.66 1,386.64 1,246.72 1,184.63 758.45 1,151.61 1,685.86 1,742.86 1,859.02 1,687.94 1,080.64 1,059.57 1,949.00 1,276.68 1,300.66 1,530.89 1,991.91 1,358.64 1,204.62 1,125.63 1,370.70 1,576.87 1,204.55 1,797.85 1,531.79 1,439.71 1,542.70 1,299.73 1,358.73 726.49 973.58 1,373.74 2,185.05 1,586.77 2,475.27 2,121.89 1,189.66 1,747.88 1,395.71 816.42 932.43 907.53 1,503.86 1,267.62 2,157.98 903.52 1,063.41 1,194.64

Table S1 page 50/159

Early endosome antigen 1

EEA1_HUMAN EEA1

162,450

100.00%

5

5

12

Protein S100-A8

S10A8_HUMAN S100A8

10,817

99.50%

2

2

9

43,045

100.00%

7

9

27

Interleukin enhancer-binding factor 2 ILF2_HUMAN ILF2

Ephrin type-B receptor 4

EPHB4_HUMAN EPHB4

108,252

99.50%

2

2

2

Pyruvate kinase isozymes M1/M2

KPYM_HUMAN PKM2

57,920

100.00%

38

50

933

3.90% AAQLATEIADIK IQNLEALLQK ITTQLDQVTAK LSASETSLHR LSLAQEDLISNR 23.70% ALNSIIDVYHK LLETECPQYIR 23.80% ILITTVPPNLR ILPTLEAVAALGNK NQDLAPNSAEQASILSLVTK QPLALNVAYR VKPAPDETSFSEALLK VLQSALAAIR WFEENASQSTVK 2.53% SSPSSLSLAWAVPR VDTVAAEHLTR 67.60% AGKPVICATQMLESMIK APIIAVTR ASDVHEVR CCSGAIIVLTK CDENILWLDYK DIQDLK DPVQEAWAEDVDLR FDEILEASDGIMVAR FGVEQDVDMVFASFIR GADFLVTEVENGGSLGSK GADFLVTEVENGGSLGSKK GDLGIEIPAEK GDYPLEAVR GIFPVLCKDPVQEAWAEDVDLR

GSGTAEVELK GSGTAEVELKK GVNLPGAAVDLPAVSEK GVNLPGAAVDLPAVSEKDIQDLK

IENHEGVR ITLDNAYMEK IYVDDGLISLQVK KGVNLPGAAVDLPAVSEK LAPITSDPTEATAVGAVEASFK LDIDSPPITAR LNFSHGTHEYHAETIK MQHLIAR NTGIICTIGPASR QKGADFLVTEVENGGSLGSK RFDEILEASDGIMVAR RLAPITSDPTEATAVGAVEASFK

SAHQVAR SGMNVAR SVETLKEMIK TATESFASDPILYRPVAVALDTK TATESFASDPILYRPVAVALDTKGPEIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0%

54.7 51.3 47.0 46.5 56.7 36.6 72.0 36.2 90.0 130.0 37.5 60.0 68.8 72.7 39.7 47.2 48.7 59.2 60.2 52.2 57.7 42.7 103.0 41.4 120.0 124.0 54.9 67.3 50.4 50.7 60.2 65.3 96.0 81.9 54.0 68.6 109.0 84.7 159.0 69.5 35.6 41.5 75.5 86.0 96.0 26.5 33.1 70.1 42.2 63.6 58.4

22.3 18.1 22.1 22.6 21.8 21.9 23.3 11.5 14.1 20.6 21.8 21.6 18.1 21.8 21.8 21.5 22.4 14.3 21.1 22.8 22.0 24.4 21.9 21.9 22.4 21.8 22.2 21.5 22.7 20.5 23.3 22.3 20.1 17.8 22.5 22.6 19.4 17.8 21.2 21.5 22.2 20.8 23.2 22.2 22.5 20.5 20.0 23.8 21.2 19.1 17.9

3 4 2 1 2 1 8 3 9 4 2 2 2 2 1 1 1 18 10 2 5 2 15 1 24 66 2 32 22 0 8 28 15 6 15 40 87 6 87 60 0 8 10 2 35 0 2 4 7 10 0

0 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 7 0 0 0 0 0 0 0 16 0 2 0 0 3 0 4 0 14 0 0 0 8 45 0 1 0 0 4 84 1 0 0 1 77 5

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,243.69 1,169.69 1,217.67 1,100.57 1,358.73 1,272.70 1,421.71 1,236.77 1,409.84 2,099.10 1,144.65 1,731.92 1,041.64 1,425.67 1,457.78 1,211.64 1,908.96 840.53 912.45 1,221.63 1,468.68 731.39 1,642.77 1,665.82 1,875.90 1,779.88 1,907.97 1,141.61 1,019.52 2,557.28 990.51 1,118.61 1,636.89 2,349.27 953.48 1,197.58 1,462.82 1,764.99 2,175.12 1,197.65 1,883.90 884.48 1,359.71 2,036.03 1,821.92 2,331.22 768.41 734.36 1,193.65 2,465.29 3,017.60

Table S1 page 51/159

VFLAQK VNFAMNVGK VVEVGSK AFFMLDGILSK EDPIVYEIHPTK ETLDAQTFHTR ETSIFSYR ETSIFSYREDPIVYEIHPTK EVFNILQAAYVSKPGAQLAR FMQVVVSR GDLTIANLGTSEGR GNDIDPEAVKGEVLK IDLANR KEVFNILQAAYVSKPGAQLAR MVINVHEAGR NLNSVSVPR QAISSTVLGK SFISGGSTITGVGK SVSNSILECYTPAQTISTEFAVK TEFTTALQR VFPNSAPLEGGTR YVNDFFNK MGNTPDSASDNLGFR QPAGPGSGIR APLQGTLLGYR LAYQGQDTPEVLMDIGLR TATITVLPQQPR AVDNQVYVATASPAR ECSIYLIGGSIPEEDAGK LALIQLQISSIK LDSVLLLSSMNLPGGELR LGQGVLVQVSPSLVK ITHSPQAHDNPQEK LAADDPEVR FNVWDTAGQEK LVLVGDGGTGK NLQYYDISAK SNYNFEKPFLWLAR VCENIPIVLCGNK YVATLGVEVHPLVFHTNR DLFLQGAYDTVR DVTADFEGQSPK

Hepatocyte growth factor receptor

MET_HUMAN MET

155,525

100.00%

19

20

90

14.50%

Sulfatase-modifying factor 2

SUMF2_HUMAN SUMF2

33,825

100.00%

2

2

3

8.31%

Tyrosine-protein kinase receptor UFO

UFO_HUMAN AXL

98,317

100.00%

3

4

59

4.59%

Omega-amidase NIT2

NIT2_HUMAN NIT2

30,591

100.00%

3

3

6

16.30%

Exosome complex exonuclease RRP4 Ephrin-A1

EXOS2_HUMAN EXOSC2

32,771

99.90%

2

2

2

11.30%

EFNA1_HUMAN EFNA1

23,769

99.90%

2

2

13

11.20%

GTP-binding nuclear protein Ran

RAN_HUMAN RAN

24,405

100.00%

6

6

27

35.60%

Dipeptidyl peptidase 2

DPP2_HUMAN DPP7

54,325

99.50%

2

2

6

4.88%

40,497

100.00%

6

6

13

27,384

100.00%

4

4

12

21.80% DGMEYPFIGEGEPHVDGEPGDLR FQDLGAAYEVLSDSEK FQDLGAAYEVLSDSEKR LALQLHPDRNPDDPQAQEK TLEVEIEPGVR TTQLGPGR 23.00% AFYAELYHIISSNLEK IEDGNDFGVAIQEK QNLFQEAEEFLYR

DnaJ homolog subfamily B member DJB11_HUMAN DNAJB11 11

Proteasome activator complex subunit 2

PSME2_HUMAN PSME2

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

35.6 61.9 32.8 78.7 69.7 68.7 44.2 55.3 83.9 57.0 106.0 74.4 39.5 31.4 40.6 65.2 50.1 107.0 45.9 56.9 39.5 42.0 56.5 41.1 90.9 102.0 50.3 92.6 66.7 33.5 33.4 50.2 26.1 54.3 79.9 58.2 33.7 35.9 73.2 22.0 48.5 61.6 26.6 128.0 32.0 34.8 51.0 34.4 56.2 110.0 76.2

19.8 22.0 25.5 21.1 22.7 22.2 20.5 20.9 18.2 22.6 22.6 21.3 22.7 14.1 22.6 20.6 19.4 21.3 21.6 22.3 22.3 22.0 19.2 21.8 21.2 22.9 16.8 22.1 21.7 10.8 20.6 13.4 22.3 20.5 21.6 21.5 22.4 21.3 22.5 19.8 22.1 21.4 17.2 21.8 22.0 22.1 20.9 21.6 21.9 22.7 21.6

2 27 1 12 2 2 2 0 1 8 14 6 2 0 2 6 1 4 2 7 2 3 1 2 26 21 11 4 1 1 1 1 0 10 13 6 3 1 2 0 3 3 0 4 0 0 2 3 2 3 4

0 0 0 0 0 0 0 4 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

705.43 995.50 717.41 1,241.66 1,440.74 1,318.64 1,002.49 2,424.21 2,175.19 965.52 1,403.71 1,583.83 701.39 2,303.29 1,141.58 985.54 1,003.58 1,310.70 2,545.25 1,066.55 1,344.69 1,046.49 1,581.70 939.50 1,188.67 2,035.02 1,324.76 1,561.80 1,937.92 1,326.84 1,930.03 1,523.92 1,601.77 985.50 1,294.61 1,015.58 1,214.61 1,784.91 1,515.77 2,052.10 1,397.71 1,293.60 2,532.10 1,771.84 1,927.94 2,185.10 1,241.67 829.45 1,897.97 1,534.74 1,686.81

Table S1 page 52/159

Perilipin-3

PLIN3_HUMAN PLIN3

47,028

100.00%

3

3

8

Phospholipid transfer protein

PLTP_HUMAN PLTP

54,723

100.00%

9

11

112

Argininosuccinate lyase

ARLY_HUMAN ASL

51,641

99.50%

2

2

3

Complement factor H

CFAH_HUMAN CFH

139,078

100.00%

35

40

244

TKVEAFQTTISK 10.40% IATSLDGFDVASVQQQR TLTAAAVSGAQPILSK VSGAQEMVSSAK 24.70% AGALQLLLVGDK ATYFGSIVLLSPAVIDSPLK AVEPQLQEEER DPVASTSNLDMDFR FLEQELETITIPDLR TGLELSRDPAGR TMLQIGVMPMLNER VPHDLDMLLR VYDFLSTFITSGMR 7.33% INVLPLGSGAIAGNPLGVDR LNSNDEDIHTANER 34.20% AGEQVTYTCATYYK AQTTVTCMENGWSPTPR CFEGFGIDGPAIAK CNMGYEYSER CTSTGWIPAPR DGWSAQPTCIK DTSCVNPPTVQNAYIVSR ECDTDGWTNDIPICEVVK ECELPK EFDHNSNIR EIMENYNIALR EQVQSCGPPPELLNGNVK FVCNSGYK GEWVALNPLR HGGLYHENMR IDVHLVPDR IDVHLVPDRK IVSSAMEPDR IVSSAMEPDREYHFGQAVR KGEWVALNPLR LGYVTADGETSGSITCGK LSYTCEGGFR NTEILTGSWSDQTYPEGTQAIYK

RPYFPVAVGK SCDIPVFMNAR SIDVACHPGYALPK SLGNVIMVCR SPDVINGSPISQK SPPEISHGVVAHMSDSYQYGEEVTYK

UPF0556 protein C19orf10

CS010_HUMAN C19orf10

18,777

100.00%

2

3

5

SSNLIILEEHLK SSQESYAHGTK TDCLSLPSFENAIPMGEK TGDEITYQCR TGESVEFVCK WQSIPLCVEK 13.90% ESDVPLKTEEFEVTK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

76.5 89.0 42.1 56.8 86.8 63.0 64.2 71.0 64.4 38.3 85.6 36.2 77.6 101.0 36.0 54.7 38.6 83.5 58.2 51.9 34.1 82.4 60.8 30.4 57.0 85.2 74.1 34.0 70.8 37.1 34.5 26.5 60.5 42.7 42.6 43.7 65.3 70.8 42.8 56.1 65.7 59.5 71.8 41.4 64.5 41.0 71.3 49.7 35.8 42.7 71.1

19.5 22.1 18.3 22.6 16.6 14.1 22.7 18.3 21.5 21.7 23.2 22.4 22.7 16.8 19.6 20.8 20.0 22.3 7.8 22.1 21.0 22.3 17.6 20.5 20.3 22.7 22.2 18.6 20.4 19.4 20.8 18.7 22.9 21.8 18.5 20.8 19.5 21.0 20.5 21.3 22.6 22.6 22.5 19.0 18.9 19.7 21.5 18.3 21.4 22.8 22.7

3 3 2 3 16 6 31 3 9 1 11 0 22 2 0 5 1 9 4 2 1 4 1 1 7 20 4 2 7 0 5 0 9 0 6 1 3 5 3 8 4 12 18 0 16 1 8 9 1 6 2

0 0 0 0 0 0 0 0 2 4 0 7 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 4 0 0 0 4 28 0 0 0 0 2 17 0 0 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,352.74 1,834.93 1,527.87 1,209.58 1,197.72 2,091.17 1,327.65 1,583.70 1,816.97 1,271.67 1,632.83 1,208.65 1,636.80 1,933.09 1,627.73 1,654.74 1,951.86 1,481.71 1,324.49 1,245.61 1,262.58 2,020.98 2,150.94 775.37 1,131.52 1,365.68 1,965.97 974.44 1,154.63 1,229.55 1,063.59 1,191.69 1,120.53 2,192.06 1,282.73 1,815.84 1,189.53 2,602.23 1,133.65 1,309.60 1,527.76 1,164.59 1,341.70 2,926.32 1,395.78 1,194.54 2,008.94 1,242.54 1,155.54 1,259.65 1,750.88

Table S1 page 53/159

Platelet-derived growth factor subunit A Annexin A7

PDGFA_HUMAN PDGFA

24,025

99.50%

2

2

3

ANXA7_HUMAN ANXA7

52,723

99.50%

2

2

11

LIM domain and actin-binding protein 1

LIMA1_HUMAN LIMA1

85,208

100.00%

3

3

5

Nuclear transport factor 2

NTF2_HUMAN NUTF2

14,461

100.00%

3

3

7

Tropomyosin beta chain

TPM2_HUMAN TPM2

32,834

100.00%

13

16

65

Phosphoglucomutase-2

PGM2_HUMAN PGM2

68,268

100.00%

5

5

8

26,680

100.00%

7

7

24

27,747

100.00%

11

11

63

EF-hand domain-containing protein EFHD2_HUMAN EFHD2 D2

14-3-3 protein theta

1433T_HUMAN YWHAQ

SYLYFTQFK 13.30% SQVDPTSANFLIWPPCVEVK TVIYEIPR 5.12% GFGTDEQAIVDVVANR SEIDLVQIK 6.46% IAWPPPTELGSSGSALEEGIK ISANENSLAVR NENEEILERPAQLANAR 29.90% ADEDPIMGFHQMFLLK LSSLPFQK NINDAWVCTNDMFR 32.00% AEFAER GTEDEVEK IQLVEEELDR IQLVEEELDRAQER KATDAEADVASLNR KYEEVAR LDKENAIDR LEEAEKAADESER LKEAETR LKGTEDEVEK LVILEGELER RIQLVEEELDR YEEVAR 8.01% AAMGPGISR DLTTGYDDSQPDKK LDQETAQWLR MEFGTAGLR QLIDQGK 24.60% ADLNQGIGEPQSPSR ADLNQGIGEPQSPSRR DGFIDLMELK LGAPQTHLGLK LSEIDVSSEGVK RADLNQGIGEPQSPSR VQAINVSSR 59.20% AVTEQGAELSNEER DSTLIMQLLR EMQPTHPIR KEMQPTHPIR LAEQAER NLLSVAYK QTIDNSQGAYQEAFDISK QTIDNSQGAYQEAFDISKK SICTTVLELLDK TAFDEAIAELDTLNEDSYK TELIQK VISSIEQK YDDMATCMK YLAEVACGDDR YLAEVACGDDRK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

46.7 42.0 36.3 89.0 52.5 41.7 60.9 32.4 49.2 31.0 85.7 30.5 33.2 69.4 50.9 110.0 30.6 32.3 77.8 42.4 30.2 41.3 32.9 38.1 43.8 64.8 45.9 50.9 31.8 68.1 35.8 44.8 30.7 82.5 44.5 50.9 104.0 79.3 67.1 43.9 59.4 51.4 119.0 69.4 74.9 107.0 36.0 65.9 32.0 35.0 56.2

22.6 21.8 20.2 22.6 19.8 21.7 22.6 22.0 22.9 20.6 19.3 22.0 21.2 22.3 21.9 22.6 22.4 23.4 21.9 24.5 23.5 20.3 21.9 22.0 23.7 20.5 22.2 21.8 21.7 22.3 23.1 23.4 18.1 23.2 23.1 22.5 21.8 21.3 22.4 22.5 21.6 19.1 21.2 22.0 21.6 21.6 23.5 22.9 10.4 18.5 21.5

2 1 2 2 9 2 2 0 4 1 2 1 1 10 7 2 1 0 11 6 0 2 2 3 2 2 2 1 1 4 0 6 0 7 3 1 8 113 13 0 36 49 4 0 6 4 4 27 1 1 2

0 0 0 0 0 0 0 1 0 0 0 0 0 0 6 0 0 2 7 0 2 0 2 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 11 0 0 0 4 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,196.60 2,287.14 990.56 1,690.84 1,044.59 2,139.10 1,173.62 1,966.99 1,891.91 919.53 1,755.76 722.35 906.41 1,243.65 1,727.89 1,460.73 894.47 1,073.56 1,476.68 846.47 1,147.58 1,170.67 1,399.75 766.37 875.44 1,582.72 1,259.64 981.48 801.45 1,568.77 1,724.87 1,180.59 1,134.66 1,262.65 1,724.87 973.54 1,532.72 1,189.66 1,108.56 1,252.65 816.42 907.53 2,014.94 2,143.03 1,391.75 2,144.99 731.43 903.52 1,134.43 1,268.56 1,396.65

Table S1 page 54/159

Protein mago nashi homolog 2

MGN2_HUMAN MAGOHB

17,259

100.00%

5

5

8

Ubiquitin-conjugating enzyme E2 variant 1 Platelet-activating factor acetylhydrolase IB subunit alpha

UB2V1_HUMAN UBE2V1

16,477

100.00%

2

2

4

LIS1_HUMAN PAFAH1B1

46,619

100.00%

8

10

15

Aldehyde dehydrogenase, dimeric NADP-preferring

AL3A1_HUMAN ALDH3A1

50,362

100.00%

17

21

200

Trifunctional purine biosynthetic protein adenosine-3

PUR2_HUMAN GART

107,750

100.00%

3

3

5

3-ketoacyl-CoA thiolase, peroxisomal

THIK_HUMAN ACAA1

44,274

100.00%

4

4

6

Spermidine synthase

SPEE_HUMAN SRM

33,807

99.50%

2

2

3

Laminin subunit alpha-3

LAMA3_HUMAN LAMA3

366,625

100.00%

43

52

416

YLIANATNPESK 35.80% IGSLIDVNQSK IGSLIDVNQSKDPEGLR IIDDSEITKEDDALWPPPDR NDVMIR VFYYLVQDLK 13.60% LLEELEEGQK WTGMIIGPPR 22.20% EEFTSGGPLGQK GHTDSVQDISFDHSGK LNEAKEEFTSGGPLGQK SGKPGPFLLSGSR SNGYEEAYSVFK TAPYVVTGSVDQTVK VWDYETGDFER YALSGHR 41.90% DLYPVINGGVPETTELLK EKPLALYMFSSNDK ERFDHILYTGSTGVGK FDHILYTGSTGVGK HLTPVTLELGGK IIMTAAAK IQQLEALQR ISEAVKR LIQEQEQELVGALAADLHK LPEWAADEPVEK SCLVRPLMNDEGLK SFETFSHR SLEEAIQFINQR SLKEFYGEDAK VAYGGTGDAATR VMGLIEGQK VRYPPSPAK 3.86% ENLISALEEAKK FGDPECQVILPLLK VDLGGFAGLFDLK 12.00% AEELGLPILGVLR GNPGNITSR IAQFLSDIPETVPLSTVNR QVITLLNELK 7.62% AAFVLPEFAR VLIIGGGDGGVLR 15.50% AASASESALQTVIK AASASESALQTVIKEDLPR AGYTGTQCER ALGAIQR ALTDADNSVNK ANDITDEVLDGLNPIQTDVER APVYLGSPPSGKPK AQTLNNNVNR CAPGYFGNPQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

74.4 62.3 42.7 57.1 36.7 51.5 46.1 43.4 37.0 70.9 51.3 31.4 41.4 75.7 76.9 33.8 67.8 48.8 26.6 66.7 56.7 40.0 68.4 34.5 104.0 68.1 53.0 36.8 82.0 49.3 95.2 48.5 31.3 52.6 55.8 72.9 76.8 36.0 79.4 48.2 35.9 45.7 84.6 94.9 74.0 40.0 76.9 98.2 56.3 52.6 40.3

23.2 23.3 20.5 22.1 24.1 22.7 22.8 20.6 22.5 20.5 22.5 22.0 20.5 22.1 17.6 22.6 20.0 22.3 22.4 22.9 18.9 22.9 18.6 22.5 19.5 22.3 23.3 21.8 22.7 22.0 22.4 22.7 22.3 21.6 21.4 21.2 14.3 20.6 19.7 17.8 21.6 17.8 22.1 21.0 18.1 20.9 22.8 21.6 20.0 21.7 20.5

2 2 0 1 2 2 2 2 1 1 1 0 2 2 2 1 3 5 0 6 2 2 16 3 4 11 2 5 15 2 51 8 1 1 2 2 2 1 2 1 2 1 8 12 3 2 30 2 9 3 2

0 0 1 0 0 0 0 0 0 2 2 1 0 0 0 0 0 1 1 0 4 0 0 0 52 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 0 1 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,320.68 1,173.65 1,840.98 2,325.13 763.38 1,287.70 1,187.62 1,127.60 1,249.61 1,729.78 1,804.91 1,302.72 1,393.63 1,564.82 1,416.61 803.42 1,958.05 1,642.82 1,779.90 1,494.76 1,264.73 834.48 1,098.63 802.48 2,105.12 1,383.68 1,647.82 1,010.47 1,447.75 1,286.63 1,138.55 974.53 1,014.57 1,344.74 1,628.87 1,351.73 1,379.83 915.46 2,100.13 1,170.71 1,120.62 1,225.73 1,375.74 1,986.05 1,142.49 728.44 1,147.56 2,327.14 1,397.78 1,143.59 1,238.56

Table S1 page 55/159

CAVDAATAYENILNAIK EAELQVDQILTK EINSLQSDFTK ELTDLNQEFETLQEK ESQLLLNR FANSPRPDLWVLER FISLNIEDGK GATSSKPETPGVYDMDGR GDIDAMISSAK GLLFFAENGDR IKDTYGR INQLLQDTPVASPR KANDITDEVLDGLNPIQTDVER KAQTLNNNVNR LAASLNEAR LGGSNFEGCISNVFVQR LKQEVSPALNNLQQTLNIVTVQK

LLIDDQLLR LPDLWR LPQELLKPR LQEAAAQAK LSLSPEVLDLTSNSLK LSLSPEVLDLTSNSLKR NSFMALYLSK QANGLNQENER QEVSPALNNLQQTLNIVTVQK QISGTDGEGNNVPSGDFSR SAISNHGSK SPQTYMDGLLHYVSVISDNSGLR

Sulfhydryl oxidase 1

QSOX1_HUMAN QSOX1

82,561

100.00%

21

24

234

SQFAVDMQTTSSR SQLQGLSASAGLLEQMR TLSSNSDKLLNEAK VPTQPHAPIPTFGQTIQTTVDR VTASMDSGAGGTSTSVTPK YKLNSELPK 32.80% AAPGQEPPEHMAELQR AHFSPSNIILDFPAAGSAAR DCASHFEQMAAASMHR DFNIPGFPTVR DVQNVAAAPELAMGALELESR EVALDLSQHK FPVLEGQR IEVGRFPVLEGQR IYMADLESALHYILR KEGAVLAK LAGAPSEDPQFPK LEEIDGFFAR NGSGAVFPVAGADVQTLR NKIPYSFFK NNEEYLALIFEK RVLNTEANVVR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

102.0 87.7 58.5 119.0 51.8 30.8 47.6 67.8 65.7 51.7 30.5 102.0 100.0 63.0 66.7 92.0 50.1 68.7 33.0 39.7 65.2 110.0 78.1 35.5 60.6 121.0 98.8 44.2 44.8 74.7 108.0 59.5 79.3 97.0 29.8 70.3 97.2 27.1 44.5 98.4 55.9 42.2 46.9 36.6 31.4 71.9 51.0 84.9 28.7 92.0 45.6

22.9 22.6 22.1 22.6 23.0 21.2 23.1 20.5 23.5 22.5 21.5 20.6 20.4 21.1 23.4 22.2 11.1 20.3 20.7 12.6 21.6 20.9 17.2 22.7 20.7 16.6 20.4 20.5 21.5 19.9 22.6 22.0 19.9 21.4 20.8 22.1 21.6 13.0 22.8 22.2 22.1 22.9 19.9 22.2 21.0 22.0 22.8 22.4 22.9 22.3 20.1

2 7 15 29 7 0 4 5 10 6 1 8 2 2 12 2 0 33 1 1 4 15 8 1 2 7 12 4 0 7 11 1 0 12 0 6 11 0 11 3 9 11 2 1 1 20 8 8 0 10 6

0 0 0 0 0 4 0 9 0 0 0 0 17 3 0 0 11 0 0 0 0 1 2 0 0 2 0 0 2 0 2 0 37 0 1 0 27 1 0 0 0 0 2 0 0 0 0 0 2 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,836.92 1,386.75 1,281.63 1,836.89 972.55 1,699.89 1,135.60 1,867.85 1,107.54 1,238.62 852.46 1,551.85 2,455.23 1,271.68 944.52 1,883.91 2,578.46 1,098.65 799.45 1,093.67 929.51 1,715.94 1,872.04 1,189.59 1,272.59 2,337.28 1,936.86 900.45 2,568.24 1,473.66 1,804.92 1,519.80 2,404.26 1,769.82 1,091.61 1,776.83 2,042.05 1,864.75 1,262.65 2,184.10 1,139.61 945.52 1,499.83 1,823.94 815.50 1,356.68 1,196.60 1,758.91 1,143.62 1,482.75 1,270.72

Table S1 page 56/159

AN32E_HUMAN ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E

Nuclease-sensitive element-binding protein 1

YBOX1_HUMAN YBX1

30,675

100.00%

3

3

4

35,906

100.00%

9

10

63

SALYSPSDPLTLLQADTVR SFYTAYLQR TALDDRK VLNTEANVVR VPVLMESR 7.46% DLSTVEALQNLK IKDLSTVEALQNLK INLELR 47.20% AADPPAENSSAPEAEQGGAE EDGNEEDKENQGDETQGQQPPQR

GAEAANVTGPGGVPVQGSK NDTKEDVFVHQTAIK NEGSESAPEGQAQQR NYQQNYQNSESGEK NYQQNYQNSESGEKNEGSESAPEGQAQQR RPQYSNPPVQGEVMEGADNQGAGEQGRPVR

49,015

100.00%

3

3

8

ODO2_HUMAN DLST Dihydrolipoyllysine-residue succinyltransferase component of 2oxoglutarate dehydrogenase SF3A3_HUMAN SF3A3 Splicing factor 3A subunit 3

48,711

100.00%

3

3

9

58,833

100.00%

4

4

7

PCNA_HUMAN PCNA

28,751

100.00%

12

14

53

Eukaryotic peptide chain release factor subunit 1

Proliferating cell nuclear antigen

ERF1_HUMAN ETF1

SVGDGETVEFDVVEGEK 7.78% GFGGIGGILR LSVLGAITSVQQR YFDEISQDTGK 9.93% AKPAEAPAAAAPK ASAFALQEQPVVNAVIDDTTK VEGGTPLFTLR 12.80% EELNAISGPNEFAEFYNR ENPSEEAQNLVEFTDEEGYGR SLESLDTSLFAK VKPLQDQNELFGK 49.00% AEDNADTLALVFEAPNQEK ATPLSSTVTLSMSADVPLVVEYK

Actin-related protein 2/3 complex subunit 4

ARPC4_HUMAN ARPC4

19,649

100.00%

3

3

9

Actin-related protein 3

ARP3_HUMAN ACTR3

47,354

100.00%

8

9

23

DLSHIGDAVVISCAK FSASGELGNGNIK LVQGSILK LVQGSILKK MPSGEFAR NLAMGVNLTSMSK SEGFDTYR VSDYEMK YLNFFTK YYLAPK 17.90% AENFFILR ELLLQPVTISR VLIEGSINSVR 30.90% AEPEDHYFLLTEPPLNTPENR DITYFIQQLLR DREVGIPPEQSLETAK LGYAGNTEPQFIIPSCIAIK LSEELSGGR NIVLSGGSTMFR TLTGTVIDSGDGVTHVIPVAEGYVIGSCIK

Adenylyl cyclase-associated protein CAP1_HUMAN CAP1

51,838

100.00%

8

10

45

YSYVCPDLVK 23.40% AGAAPYVQAFDSLLAGPVAEYLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

121.0 51.0 36.0 51.0 50.2 47.3 49.1 39.6 36.1 43.3 115.0 35.6 70.5 37.8 85.1 61.5 45.0 40.9 65.0 62.0 39.8 108.0 52.8 73.8 119.0 65.8 46.2 90.9 50.8 65.1 98.0 32.1 43.5 43.7 83.3 47.9 49.0 37.8 31.5 49.8 66.4 58.2 28.8 46.9 81.2 76.7 59.3 66.4 33.3 38.8 77.6

21.4 23.3 24.3 22.9 23.1 22.7 17.9 21.8 17.7 15.8 22.3 22.7 19.2 17.7 15.6 20.6 21.7 20.1 17.8 18.5 21.6 20.9 21.6 20.6 17.8 22.1 21.5 21.7 20.4 22.5 23.2 19.2 11.5 20.6 23.3 15.7 17.1 23.6 19.6 21.7 17.1 21.2 21.8 19.1 21.9 21.3 23.5 22.3 19.2 20.2 20.0

64 10 4 12 3 1 1 2 2 0 25 0 6 1 0 0 2 2 3 3 0 2 2 1 2 2 2 19 2 2 3 2 2 7 7 2 2 1 2 5 2 2 0 2 4 2 5 5 0 2 2

2 0 0 0 0 0 0 0 0 18 0 2 0 0 5 1 0 0 0 0 5 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,047.07 1,148.57 818.44 1,114.62 946.50 1,330.72 1,571.90 757.46 1,897.81 2,628.11 1,695.87 1,744.89 1,587.70 1,688.72 3,257.40 3,239.53 1,795.82 946.55 1,371.80 1,302.59 1,192.67 2,217.14 1,189.66 2,099.97 2,413.04 1,310.68 1,515.82 2,074.99 2,424.26 1,584.81 1,293.64 857.55 985.64 910.41 1,365.69 974.42 871.39 932.49 754.41 1,009.55 1,268.76 1,186.68 2,482.19 1,409.78 1,768.91 2,192.14 947.48 1,297.66 3,058.58 1,243.60 2,351.23

Table S1 page 57/159

1

OSMR_HUMAN OSMR Oncostatin-M-specific receptor subunit beta SUMO-activating enzyme subunit 1 SAE1_HUMAN SAE1

110,492

99.90%

2

2

2

2.55%

38,432

100.00%

3

3

6

9.83%

EIGGDVQK EMNDAAMFYTNR LSDLLAPISEQIK NSLDCEIVSAK SGPKPFSAPKPQTSPSPK VENQENVSNLVIEDTELK VPTISINK LPLTPVSLK QPSQSYTLFESFSGEK AQNLNPMVDVK LDSSETTMVK VSQGVEDGPDTKR EDARPVPQGSCQSELHR LPGGLEPK QCHPALDGQR TGVKLPGGLEPK THEDLYIIPIPNCDR AAEDDEDDDVDTK AAEDDEDDDVDTKK EVVEEAENGR AFAVGVQQVLLK AIFQTIQNR ENIVEAIIHSPELIR ETENDDLTNVIQK EYNEFAEVFLK GIDQCIPLFVEAALER GTMDPALR QLQDIATLADQR QLQDIATLADQRR SDQNLQTALELTR ELPQFATGENLPR GTLGGLFSQILQGEDIVR DCLLELIEQK FGGSFLNCVR ILNETGK LPQVLAHLGALK QEVEIR SDTDVSMPLVEER SYENQKPPFDAK

Insulin-like growth factor-binding protein 4

IBP4_HUMAN IGFBP4

27,916

100.00%

5

5

25

20.90%

Prothymosin alpha

PTMA_HUMAN PTMA

12,185

100.00%

3

3

8

21.60%

Importin-7

IPO7_HUMAN IPO7

119,502

100.00%

10

10

17

10.60%

Apoptosis inhibitor 5

API5_HUMAN API5

57,545

99.50%

2

2

8

6.08%

UPF0553 protein C9orf64

CI064_HUMAN C9orf64

39,012

100.00%

5

6

9

17.00%

NADPH--cytochrome P450 reductase Lactoylglutathione lyase

NCPR_HUMAN POR

76,673

99.50%

2

2

3

5.17%

LGUL_HUMAN GLO1

20,761

100.00%

4

4

26

PCNP_HUMAN PCNP

18,907

100.00%

4

5

10

Rab GDP dissociation inhibitor alpha GDIA_HUMAN GDI1

50,566

100.00%

10

10

30

25.00% DFLLQQTMLR GLAFIQDPDGYWIEILNPNK IAWALSR VLGMTLIQK 29.80% AGAAGGPEEEAEKPVK FGFAIGSQTTK SAEEEAADLPTKPTK SHLGNVHDQDN 45.00% DWNVDLIPK FLMANGQLVK FQLLEGPPESMGR

PEST proteolytic signal-containing nuclear protein

YESGDHVAVYPANDSALVNQLGK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

35.0 76.7 70.9 35.6 50.7 116.0 33.9 34.6 41.4 44.9 39.1 41.4 55.8 35.2 40.0 49.0 76.3 67.4 89.5 63.3 70.8 49.3 42.8 66.5 36.1 38.2 43.7 53.7 28.3 77.4 60.8 53.1 47.6 42.4 37.1 58.2 37.8 48.4 43.1 27.8 77.6 112.0 45.1 59.2 76.2 61.0 71.6 39.0 43.3 43.4 78.3

22.0 14.5 18.0 22.5 20.5 22.4 20.4 6.0 22.9 23.7 20.9 22.2 21.1 16.2 21.0 15.7 21.8 10.0 16.6 20.8 14.3 22.2 20.1 22.3 21.0 22.3 23.1 22.7 21.9 22.9 22.4 19.9 23.6 21.3 24.6 10.4 23.5 20.9 21.9 21.6 22.4 20.5 22.3 18.5 21.9 22.2 22.4 18.2 21.6 22.8 23.0

3 5 15 2 0 10 3 1 1 2 2 2 0 1 0 0 5 2 2 4 2 2 2 2 2 1 1 2 0 2 6 2 1 2 1 2 1 1 2 0 8 4 7 7 2 2 2 2 2 6 4

0 0 0 0 2 2 0 0 0 0 0 0 7 0 8 4 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 2 0 0 0 1 0 0 0 0 0 0 2 0 0 0 0

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

845.44 1,494.60 1,426.82 1,235.59 1,837.98 2,073.04 871.53 967.62 1,834.85 1,244.63 1,126.53 1,387.68 1,965.92 810.47 1,181.55 1,195.71 1,855.90 1,437.55 1,565.65 1,131.53 1,272.77 1,090.60 1,732.96 1,518.73 1,388.67 1,830.94 876.43 1,371.72 1,527.82 1,488.77 1,471.75 1,903.03 1,260.65 1,156.56 774.44 1,259.78 773.42 1,493.68 1,423.69 2,447.18 1,280.67 2,303.17 816.47 1,002.60 1,539.77 1,156.60 1,586.79 1,235.54 1,099.58 1,136.61 1,460.72

Table S1 page 58/159

Calcium-binding protein 39

CAB39_HUMAN CAB39

39,853

100.00%

4

4

4

Arginyl-tRNA synthetase, cytoplasmic

SYRC_HUMAN RARS

75,364

100.00%

5

5

13

Fibulin-1

FBLN1_HUMAN FBLN1

77,194

100.00%

13

13

113

GRDWNVDLIPK IICILSHPIK IYKVPSTETEALASNLMGMFEK KQNDVFGEAEQ LYSESLAR MAGTAFDFENMKR MLLYTEVTR NPYYGGESSSITPLEELYK NTNDANSCQIIIPQNQVNR SPYLYPLYGLGELPQGFAR TDDYLDQPCLETVNR TFEGVDPQTTSMR VPSTETEALASNLMGMFEK VVEGSFVYK 12.90% FQNDRTEDEQFNDEK LIEFLSK LLGELLLDR LLSAEFLEQHYDR 10.60% AAYPDLENPPLLVTPSQQAK GFDILGIKPVQR SDGGYTYDTSDLAAIK STIIGESISR VIVDFSSPNIAK 21.50% AITPPHPASQANIIFDITEGNLR CLAFECPENYR DSFDIIKR EFTRPEEIIFLR GYHLNEEGTR IIEVEEEQEDPYLNDR LEMNYVVGGVVSHR MCVDVNECQR SAATLQQEK SQETGDLDVGGLQETDK SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDR

Leucine-rich PPR motif-containing protein, mitochondrial

LPPRC_HUMAN LRPPRC

157,894

100.00%

6

6

9

Inorganic pyrophosphatase

IPYR_HUMAN PPA1

32,643

100.00%

4

4

7

Translationally-controlled tumor protein

TCTP_HUMAN TPT1

19,578

100.00%

5

7

51

TGYYFDGISR YMDGMTVGVVR 5.09% LQDAINILK NVQGIIEILK SNTLPISLQSIR SYVSEKDVTSAK TVLDQQQTPSR TVQLTSSELESTLETLK 19.40% AAPFSLEYR DKDFAIDIIK VIAINVDDPDAANYNDINDVK VLGILAMIDEGETDWK 33.10% DGLEMEKC DLISHDEMFSDIYK EDGVTPYMIFFK GKLEEQRPER VKPFMTGAAEQIK

95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

36.0 26.5 32.2 43.0 55.9 36.4 53.4 108.0 59.4 98.6 79.5 79.6 104.0 30.8 26.2 31.9 57.2 27.4 79.9 35.2 81.8 31.7 67.7 59.1 53.0 40.1 44.5 39.8 98.8 28.3 53.3 64.8 137.0 71.0 76.1 73.4 32.8 31.1 40.3 44.3 55.6 46.0 35.7 51.6 110.0 50.7 34.8 88.5 65.4 39.9 56.1

21.5 16.9 21.6 20.9 20.3 18.3 23.0 22.1 21.9 21.6 20.2 21.4 21.2 20.9 16.5 14.1 19.1 22.6 20.5 18.6 21.2 22.2 21.1 19.7 16.6 21.6 20.4 19.5 21.1 23.0 15.2 23.1 22.4 19.4 21.7 21.0 17.8 17.2 20.7 22.1 22.7 20.2 22.0 21.7 22.2 22.1 12.3 21.5 22.4 21.1 21.2

1 0 0 4 6 2 13 2 1 8 2 4 8 1 0 1 1 0 4 0 2 2 4 0 3 5 5 12 6 0 10 3 8 0 18 5 1 1 1 1 4 1 2 2 2 1 1 17 10 2 9

0 1 2 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 28 0 0 0 0 0 2 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 5

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,312.70 1,193.71 2,491.21 1,264.58 938.49 1,549.68 1,125.60 2,147.02 2,199.06 2,141.11 1,838.82 1,468.67 2,070.97 1,027.55 1,914.81 849.51 1,041.63 1,620.80 2,152.13 1,342.79 1,676.77 1,062.58 1,289.71 2,475.30 1,458.61 993.54 1,549.84 1,175.54 1,990.92 1,575.80 1,326.52 975.51 1,791.83 3,763.73 1,178.55 1,227.59 1,027.62 1,126.68 1,328.75 1,313.66 1,272.66 1,878.99 1,053.54 1,177.65 2,288.10 1,805.90 997.40 1,712.78 1,446.70 1,241.66 1,419.77

Table S1 page 59/159

Ras-related protein Rab-1B

RAB1B_HUMAN RAB1B

22,154

99.50%

2

3

5

Actin, cytoplasmic 1

ACTB_HUMAN ACTB

41,720

100.00%

19

28

1414

34.80% EFADSLGIPFLETSAK LLLIGDSGVGK LQIWDTAGQER MGPGAASGGERPNLK NATNVEQAFMTMAAEIK 58.70% AGFAGDDAPR AVFPSIVGRPR CDVDIRK DLTDYLMK DLYANTVLSGGTTMYPGIADR DSYVGDEAQSK DSYVGDEAQSKR EITALAPSTMK GYSFTTTAER HQGVMVGMGQK IIAPPER IIAPPERK IWHHTFYNELR KDLYANTVLSGGTTMYPGIADR LCYVALDFEQEMATAASSSSLEK

QEYDESGPSIVHR SYELPDGQVITIGNER TTGIVMDSGDGVTHTVPIYEGYALPHAILR

ATP synthase subunit alpha, mitochondrial

ATPA_HUMAN ATP5A1

Serine/threonine-protein phosphatase 2AAA_HUMAN PPP2R1A 2A 65 kDa regulatory subunit A alpha isoform

59,734

100.00%

4

4

6

65,292

100.00%

10

13

31

Galectin-3

LEG3_HUMAN LGALS3

26,135

100.00%

6

10

65

Serine protease HTRA1

HTRA1_HUMAN HTRA1

51,269

100.00%

12

13

78

VAPEEHPVLLTEAPLNPK 9.22% AVDSLVPIGR TGAIVDVPVGEELLGR TGTAEMSSILEER VVDALGNAIDGK 25.00% AISHEHSPSDLEAHFVPLVK IGPILDNSTLQSEVKPILEK LAGGDWFTSR LTQDQDVDVK MAGDPVANVR NLCSDDTPMVR QLSQSLLPAIVELAEDAK SALASVIMGLSPILGK SEIIPMFSNLASDEQDSVR VLAMSGDPNYLHR 28.40% GNDVAFHFNPR IALDFQR IQVLVEPDHFK MLITILGTVKPNANR QSVFPFESGKPFK VAVNDAHLLQYNHR 27.70% ADIALIK ESTLNMVVR EVPVASGSGFIVSEDGLIVTNAHVVTNK

GACGQGQEDPNSLR IAPAVVHIELFR IDHQGKLPVLLLGR IKDVDEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

77.3 58.7 61.5 51.6 84.4 81.5 65.7 34.7 51.3 125.0 81.6 63.0 68.7 76.4 48.0 42.4 39.0 55.8 96.1 99.6 58.9 125.0 74.2 85.4 31.1 30.5 67.5 56.7 22.0 84.4 55.2 37.1 66.6 39.0 84.9 37.8 105.0 73.9 66.6 43.1 54.1 86.9 41.8 75.1 35.5 33.6 29.9 38.2 51.1 50.7 35.9

23.1 20.3 22.2 21.6 19.7 21.2 18.6 23.7 20.6 21.7 19.0 21.6 23.5 20.0 21.7 17.9 16.0 22.4 21.4 20.3 21.4 22.9 20.0 18.4 19.3 20.2 20.6 23.1 21.0 14.6 21.7 23.6 22.0 18.1 18.6 15.7 22.4 21.8 21.8 24.4 20.6 14.8 22.1 22.6 19.8 23.5 19.2 18.6 15.2 10.8 24.7

7 2 7 2 2 149 47 1 26 149 88 43 60 154 19 6 5 0 2 26 36 175 0 60 2 1 1 2 0 2 2 2 2 1 7 2 4 2 10 4 7 9 1 2 3 2 0 1 2 0 1

0 0 0 1 0 0 0 0 0 6 0 7 0 0 13 0 0 53 10 22 53 2 81 44 0 0 0 0 0 1 0 0 0 0 1 0 0 2 0 0 11 12 5 4 0 0 2 0 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,724.87 1,071.64 1,316.66 1,457.72 1,900.88 976.45 1,198.71 905.45 1,014.48 2,231.07 1,198.52 1,354.62 1,177.61 1,132.53 1,171.57 795.47 923.57 1,515.75 2,359.16 2,566.17 1,516.70 1,790.89 3,183.62 1,954.07 1,026.59 1,624.89 1,439.67 1,171.63 2,213.14 2,194.23 1,109.54 1,160.58 1,045.51 1,323.57 1,925.06 1,572.90 2,138.01 1,488.73 1,273.61 862.48 1,324.73 1,640.95 1,497.77 1,649.85 743.47 1,064.54 2,839.48 1,488.65 1,364.81 1,558.94 846.46

Table S1 page 60/159

Dermcidin

DCD_HUMAN DCD

11,266

99.50%

2

2

69

Vacuolar protein sorting-associated protein 35

VPS35_HUMAN VPS35

91,692

100.00%

11

11

30

LHRPPVIVLQR LPVLLLGR MMSLTSSK VTAGISFAIPSDK YNFIADVVEK 20.00% DAVEDLESVGK ENAGEDPGLAR 17.60% AELAELPLR ENDAVTIQVLNQLIQK GVQHPLR ILVGTNLVR IPVDTYNNILTVLK IREDLPNLESSEETEQINK LLDEAIQAVK LSQLEGVNVER PTTQQSPQDEQEKLLDEAIQAVK

SEDPDQQYLILNTAR VADLYELVQYAGNIIPR AMGPLVLTEVLFNEK VLTLSDDLER EFPGFLENQKDPLAVDK FAGDKGYLTK PSQMEHAMETMMFTFHK ATIGADFLTK DPENFPFVVLGNK EAINVEQAFQTIAR FQSLGVAFYR LVTMQIWDTAGQER NNIPYFETSAK TSLMNQYVNK ALDTMNFDVIK EFSPFGSITSAK FSPAGPVLSIR GFGFVCFSSPEEATK SLGYAYVNFQQPADAER

49,205

99.50%

2

2

4

5.80%

S10AA_HUMAN S100A10

11,186

100.00%

3

5

9

45.40%

Ras-related protein Rab-7a

RAB7A_HUMAN RAB7A

23,472

100.00%

7

8

27

39.60%

Polyadenylate-binding protein 4

PABP4_HUMAN PABPC4

70,766

99.50%

2

2

5

10.20%

Legumain

LGMN_HUMAN LGMN

49,393

100.00%

7

7

41

Coronin-1B

COR1B_HUMAN CORO1B

54,217

99.50%

2

2

5

ATP-dependent RNA helicase DDX1 Myosin-9

DDX1_HUMAN DDX1

82,415

100.00%

2

2

3

MYH9_HUMAN MYH9

226,520

100.00%

38

44

163

21.00% ASSPVPLPPVTHLDLTPSPDVPLTIMK DYTGEDVTPQNFLAVLR IVSLLAASEAEVEQLLSER KLMNTNDLEESR LMNTNDLEESR QLTEEIQR VMQFQGMK 4.29% DADPILISLR VGIIAWHPTAR 2.57% ELAEQTLNNIK TGASVLNK 24.50% AGVLAHLEEER ALEEAMEQK ALELDSNLYR ANLQIDQINTDLNLER DFSALESQLQDTQELLQEENR

Eukaryotic translation initiation factor 5 Protein S100-A10

IF5_HUMAN

EIF5

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

41.1 57.6 50.2 42.6 55.8 50.7 90.3 46.3 79.1 30.5 63.1 79.8 45.7 54.4 70.8 48.8 73.2 34.0 75.7 35.8 64.8 33.6 20.0 59.5 64.4 89.0 67.9 83.8 32.1 31.5 73.5 41.4 48.9 61.6 97.2 50.0 78.1 64.7 75.1 65.0 47.0 31.1 57.1 34.2 46.1 41.0 48.5 48.8 69.8 133.0 125.0

9.0 6.0 16.8 22.0 22.0 23.0 20.9 17.7 19.1 20.5 16.7 17.6 21.8 21.6 22.3 21.4 22.5 20.8 21.3 23.5 22.5 22.6 17.5 20.2 22.5 22.4 22.0 23.3 21.7 21.7 21.7 21.6 21.1 19.8 21.3 17.4 22.1 18.4 21.1 20.1 22.3 18.7 19.9 20.5 22.7 22.9 23.8 22.2 23.2 22.0 20.8

2 45 3 1 8 1 68 4 2 1 1 10 0 2 3 0 2 0 3 1 4 2 0 2 4 12 2 4 1 1 12 1 4 1 5 0 17 1 5 6 5 1 3 0 2 1 1 3 5 4 5

6 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 1 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 2 0 0 1 0 0 0 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,327.83 880.60 916.41 1,305.71 1,197.62 1,161.56 1,128.53 1,011.58 1,826.00 806.46 984.62 1,602.91 2,244.10 1,099.64 1,243.66 2,596.31 1,762.86 1,934.04 1,676.89 1,160.62 1,946.99 1,099.58 2,082.89 1,036.57 1,475.75 1,589.83 1,187.62 1,647.82 1,283.63 1,213.59 1,282.64 1,270.63 1,143.65 1,662.75 1,928.91 2,838.53 1,937.96 2,057.11 1,465.70 1,337.60 1,016.54 1,000.46 1,112.63 1,220.69 1,272.68 789.45 1,223.64 1,064.49 1,193.62 1,869.97 2,493.17

Table S1 page 61/159

Glypican-1

GPC1_HUMAN GPC1

61,663

100.00%

18

22

271

ELEDATETADAMNR ELESQISELQEDLESER EMEAELEDERK FVSELWK HSQAVEELAEQLEQTKR IAEFTTNLTEEEEK IAEFTTNLTEEEEKSK IAQLEEELEEEQGNTELINDR IAQLEEQLDNETK IAQLEEQLDNETKER IIGLDQVAGMSETALPGAFK IMGIPEEEQMGLLR IRELESQISELQEDLESER KEEELQAALAR KFDQLLAEEK KQELEEICHDLEAR LDPHLVLDQLR LQVELDNVTGLLSQSDSK MQQNIQELEEQLEEEESAR NFINNPLAQADWAAK NLPIYSEEIVEMYK NRDEAIK NTDQASMPDNTAAQK QAQQERDELADEIANSSGK QLEEAEEEAQR QLLQANPILEAFGNAK QQQLTAMK RGDLPFVVPR TEMEDLMSSKDDVGK THEAQIQEMR VEAQLQELQVK VISGVLQLGNIVFK VKLQEMEGTVK 37.30% DVQDFWISLPGTLCSEK ERPPSGTLEK GCLANQADLDAEWR GFSLSDVPQAEISGEHLR KVAQVPLGPECSR MALSTASDDR QAEALRPFGEAPR QQIMQLK SFVQGLGVASDVVR SFVQGLGVASDVVRK SHAELETALR TLQATFPGAFGELYTQNAR VAQVPLGPECSR VIQGCGNPK VLQAMLATQLR VNPQGPGPEEK VNPQGPGPEEKR YLPEVMGDGLANQINNPEVEVDITKPDMTIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

88.5 107.0 45.1 33.0 50.3 101.0 87.6 98.9 83.1 27.0 92.1 64.0 47.9 66.7 35.6 31.3 50.3 65.3 137.0 82.4 33.7 37.2 94.1 55.2 70.5 81.5 36.3 26.4 57.4 38.7 37.6 60.0 31.1 50.6 41.6 62.1 56.1 45.6 61.9 32.8 32.8 97.2 74.7 40.2 105.0 48.5 38.4 51.7 44.8 52.9 80.9

17.0 21.4 20.0 22.0 21.9 22.0 22.3 20.6 22.3 22.3 21.3 23.3 21.6 22.8 22.6 21.8 18.9 21.4 20.3 22.6 20.6 23.0 18.1 20.7 20.4 19.4 23.6 19.6 17.0 21.5 21.1 12.0 22.8 22.1 21.2 20.3 21.8 21.6 20.5 21.9 23.4 21.3 18.8 22.7 23.2 22.3 21.3 20.4 23.0 22.7 19.8

8 6 3 1 0 6 1 2 8 0 12 3 0 5 1 0 4 3 1 6 2 1 5 0 3 28 1 0 2 2 2 3 0 4 9 2 6 2 9 0 3 61 2 5 54 8 4 13 35 13 0

0 0 0 0 2 0 0 2 0 1 0 0 2 0 0 1 5 0 3 0 0 0 0 3 0 0 0 1 1 0 0 0 2 0 0 0 9 7 0 4 0 0 0 0 12 0 0 0 0 7 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,581.67 2,033.95 1,394.61 908.49 1,996.01 1,653.79 1,868.91 2,472.17 1,530.77 1,815.91 2,018.06 1,647.81 2,303.14 1,257.68 1,220.65 1,769.85 1,318.75 1,946.01 2,333.06 1,672.84 1,743.85 845.45 1,591.70 2,088.98 1,331.61 1,726.95 963.49 1,155.66 1,716.73 1,258.59 1,284.72 1,486.90 1,277.68 1,994.95 1,113.59 1,618.73 1,941.97 1,440.76 1,082.48 1,441.76 904.49 1,433.78 1,561.87 1,126.59 2,085.04 1,312.67 972.49 1,259.71 1,151.57 1,307.67 3,503.70

Table S1 page 62/159

Profilin-1

PROF1_HUMAN PFN1

15,036

100.00%

8

13

157

Chromobox protein homolog 5

CBX5_HUMAN CBX5

22,208

100.00%

2

2

4

Macrophage migration inhibitory factor Pyridoxal kinase

MIF_HUMAN

12,459

99.50%

2

2

8

PDXK_HUMAN PDXK

35,084

100.00%

5

5

9

Coproporphyrinogen-III oxidase, mitochondrial 5'(3')-deoxyribonucleotidase, cytosolic type

HEM6_HUMAN CPOX

50,134

100.00%

2

2

6

NT5C_HUMAN NT5C

23,365

100.00%

3

3

6

Beta-galactosidase

BGAL_HUMAN GLB1

76,060

100.00%

2

2

9

Metastasis-associated protein MTA2 MTA2_HUMAN MTA2

75,007

99.50%

2

2

2

Nucleosome assembly protein 1-like NP1L1_HUMAN NAP1L1 1 PSD11_HUMAN PSMD11 26S proteasome non-ATPase regulatory subunit 11

45,357

100.00%

2

2

10

47,448

100.00%

4

4

6

MIF

55.70% CYEMASHLR DSLLQDGEFSMDLR DSPSVWAAVPGK STGGAPTFNVTVTK TDKTLVLLMGK TFVNITPAEVGVLVGK TFVNITPAEVGVLVGKDR TLVLLMGK 14.70% SNFSNSADDIK TADSSSSEDEEEYVVEK 17.40% LLCGLLAER PMFIVNTNVPR 24.00% AQAGEGVRPSPMQLELR GQVLNSDELQELYEGLR NPAGSVVMER VVPLADIITPNQFEAELLSGR YDYVLTGYTR 6.61% ATSLGRPEEEEDELAHR IESILMSLPLTAR 19.90% LLSWSDNWR VLVDMDGVLADFEAGLLR WVEQHLGPQFVER 4.28% AYVAVDGIPQGVLER TEAVASSLYDILAR 7.04% LNPADAPNPVVFVATK VKPTLIAVRPPVPLPAPSHPASTNEPIVLED

Apolipoprotein A-I

APOA1_HUMAN APOA1

30,761

100.00%

3

3

7

Thioredoxin-like protein 1

TXNL1_HUMAN TXNL1

32,233

100.00%

4

5

7

Radixin

RADI_HUMAN RDX

68,548

100.00%

9

10

24

6.91% FYEEVHDLER LDGLVETPTGYIESLPR 12.30% EASIDILHSIVK IMLNTPEDVQALVSGK LYDNLLEQNLIR TGQAAELGGLLK 15.40% DYVSQFEGSALGK EQLGPVTQEFWDNLEK VSFLSALEEYTK 17.00% IFINLPR IKQHLENDPGSNEDTDIPK QHLENDPGSNEDTDIPK SEPTQALELTEDDIKEDGIVPLR 36.20% AFAAQEDLEK ALELDQER APDFVFYAPR EKEELMER ENPLQFK FVIKPIDK IAQDLEMYGVNYFEIK IGFPWSEIR ILALCMGNHELYMR KALELDQER KAPDFVFYAPR KENPLQFK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

44.5 105.0 61.2 78.5 65.1 102.0 86.8 56.4 42.9 130.0 66.2 72.6 26.8 103.0 46.3 56.6 61.9 32.6 78.5 37.5 111.0 32.8 38.4 80.9 63.7 30.7 48.4 80.5 34.7 65.0 83.4 68.5 41.7 78.3 85.9 44.0 48.1 48.8 38.7 40.5 34.1 80.6 33.2 35.5 41.1 55.0 68.8 40.7 31.0 47.6 31.1

18.5 21.4 21.4 23.1 17.6 17.7 17.2 17.6 20.9 14.3 22.2 23.9 21.4 22.5 21.7 17.7 22.2 21.8 19.6 22.5 21.7 21.6 22.1 21.6 20.0 13.6 21.0 21.1 18.8 22.2 20.8 22.4 21.1 22.7 21.5 20.3 22.0 19.6 21.0 23.6 21.5 21.7 21.6 24.5 17.2 23.2 23.4 21.7 23.2 22.3 21.9

3 78 4 8 10 22 2 14 2 2 4 4 0 3 2 1 2 0 4 2 2 0 2 7 1 0 4 6 1 1 2 2 1 4 2 2 0 1 0 3 1 84 2 1 6 2 121 2 1 25 1

2 2 0 0 7 2 3 0 0 0 0 0 1 0 0 0 0 2 0 0 0 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 2 0 0 0 0 0 0 0 0 0 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,182.50 1,625.75 1,213.62 1,379.72 1,218.71 1,643.94 1,915.07 874.54 1,197.54 1,903.79 1,044.59 1,303.68 1,838.95 1,962.98 1,059.53 2,282.24 1,250.61 1,938.92 1,459.82 1,176.58 1,949.01 1,624.82 1,586.85 1,508.80 1,652.90 3,254.82 1,336.62 1,859.98 1,324.75 1,730.90 1,503.82 1,157.65 1,400.67 1,932.93 1,386.72 872.54 2,150.04 1,908.86 2,568.31 1,121.55 973.50 1,182.59 1,079.50 875.46 959.59 1,948.94 1,104.58 1,752.82 1,101.59 1,310.69 1,003.56

Table S1 page 63/159

KPDTIEVQQMK KTQNDVLHAENVK LFFLQVK LKQIEEQTIK NISFNDKK NQEQLAAELAEFTAK QAADQMKNQEQLAAELAEFTAK

S-formylglutathione hydrolase

ESTD_HUMAN ESD

31,446

100.00%

8

8

28

QLFDQVVK QLQALSSELAQAR RKPDTIEVQQMK VLEQHK VTTMDAELEFAIQPNTTGK 38.30% AFSGYLGTDQSK AYDATHLVK FAVYLPPK KAFSGYLGTDQSK MYSYVTEELPQLINANFPVDPQR

SGYHQSASEHGLVVIAPDTSPR SVSAFAPICNPVLCPWGK SYPGSQLDILIDQGK ATVLNYLPK GPTQEFK LPPNVVEESAR QTVSWAVTPK AAPEASGTPSSDAVSR DAGPLLISLK KGTVVAEK IVLTNPVCTEVGEK VGQEIEVRPGIVSK FNEVAAQYSEDK

Alpha-2-macroglobulin

A2MG_HUMAN A2M

163,273

100.00%

4

4

12

2.51%

Coronin-1A

COR1A_HUMAN CORO1A

51,008

100.00%

3

3

7

7.38%

Eukaryotic translation initiation factor 2 subunit 3 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Renin receptor

IF2G_HUMAN EIF2S3

51,092

100.00%

2

3

5

5.93%

PIN4_HUMAN PIN4

13,792

99.50%

2

2

5

32.10%

RENR_HUMAN ATP6AP2

38,991

100.00%

2

2

4

D-dopachrome decarboxylase

DOPD_HUMAN DDT

12,694

100.00%

4

4

9

Syntaxin-binding protein 2

STXB2_HUMAN STXBP2

66,423

99.50%

2

2

2

V-set and transmembrane domaincontaining protein 2-like protein Platelet-activating factor acetylhydrolase IB subunit beta T-complex protein 1 subunit theta

VTM2L_HUMAN VSTM2L

22,331

99.50%

2

2

2

PA1B2_HUMAN PAFAH1B2

25,552

99.90%

2

3

28

TCPQ_HUMAN CCT8

59,603

100.00%

15

15

33

7.43% LFQENSVLSSLPLNSLSR SFDTSLIR 36.40% FFPLESWQIGK PFLELDTNLPANR PFLELDTNLPANRVPAGLEK SHSAHFFEFLTK 3.88% ILSGVIR LIVPVLLDAAVPAYDK 18.10% VQPGENSVLHLPEAPPAAPAPPPPKPGK VVGSNISHK 12.20% ELFSPLHALNFGIGGDTTR IIVLGLLPR 31.60% AIADTGANVVVTGGK ANEVISK APGFAQMLK AVDDGVNTFK DIDEVSSLLR DMLEAGILDTYLGK EDGAISTIVLR FAEAFEAIPR

GSMVGPFQEAAFALPVSGMDKPVFTDPPVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0%

64.0 27.7 42.2 28.2 31.2 109.0 26.4 58.8 101.0 51.6 34.7 106.0 70.0 48.9 51.0 64.6 46.7 31.5 61.5 76.5 46.2 31.5 40.0 43.8 82.2 48.2 30.1 32.8 45.8 85.7 44.4 92.5 32.9 61.0 81.2 38.8 39.8 33.9 30.0 42.4 35.6 74.1 55.9 83.2 52.5 39.6 30.2 54.0 70.1 40.1 78.6

23.1 22.8 18.9 20.0 22.7 23.0 21.8 21.4 22.0 22.3 19.1 22.4 21.8 23.3 21.4 22.7 21.8 21.8 22.7 22.3 18.4 23.7 22.4 23.0 20.3 16.0 21.9 22.8 18.3 18.6 20.7 19.4 20.3 21.8 22.1 18.1 22.8 21.8 14.6 16.5 20.0 22.1 4.8 22.1 25.0 23.4 22.3 23.8 22.6 23.0 21.2

5 0 11 0 2 8 0 19 3 12 2 27 8 4 6 2 0 0 2 2 2 2 1 7 4 2 1 1 2 2 0 3 1 3 2 0 0 1 1 0 1 2 24 2 2 2 1 2 4 2 4

0 1 0 2 0 2 1 0 0 33 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 0 0 2 0 3 0 0 0 0 2 2 0 0 1 0 2 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,316.69 1,495.79 894.55 1,229.71 965.51 1,662.83 2,451.18 976.55 1,414.77 1,488.78 753.43 2,082.01 1,273.61 1,017.54 934.54 1,401.70 2,740.33 2,308.13 2,002.99 1,633.84 1,018.59 806.41 1,210.64 1,116.61 1,502.71 1,026.62 831.49 1,558.82 1,510.86 1,400.63 3,151.55 2,004.08 938.49 1,351.71 1,499.79 2,194.19 1,450.71 757.49 1,696.99 2,792.51 940.52 2,045.05 993.68 1,372.74 760.42 962.51 1,065.52 1,146.60 1,538.78 1,173.65 1,150.59

Table S1 page 64/159

Erythrocyte band 7 integral membrane protein

STOM_HUMAN STOM

31,714

100.00%

10

11

58

46.50%

EH domain-containing protein 1

EHD1_HUMAN EHD1

60,611

100.00%

3

3

4

7.30%

Citrate synthase, mitochondrial

CISY_HUMAN CS

51,696

100.00%

9

9

23

20.00%

Tryptophanyl-tRNA synthetase, cytoplasmic

SYWC_HUMAN WARS

53,150

100.00%

8

11

45

27.40%

Leukocyte elastase inhibitor

ILEU_HUMAN SERPINB1

42,726

100.00%

14

16

62

38.30%

GSTDNLMDDIER LFVTNDAATILR LVPGGGATEIELAK QYGNEVFLAK TAEELMNFSKGEENLMDAQVK VADMALHYANK YNIMLVR AMAAEAEASR EASMVITESPAALQLR GPGLFFILPCTDSFIK LLAQTTLR LPVQLQR NSTIVFPLPIDMLQGIIGAK TISFDIPPQEILTK VIAAEGEMNASR VQNATLAVANITNADSATR YLQTLTTIAAEK ELVNNLGEIYQK LLDTVDDMLANDIAR QEESLMPSQVVK ALGFPLERPK AYAQGISR DILADLIPK DVSDEKLR DYIWNTLNSGR GLVYETSVLDPDEGIR HLPNDPMFK IVPNVLLEQGK VVPGYGHAVLR AGNASKDEIDSAVK ALIEVLQPLIAEHQAR DLTLDQAYSYAVENAK DMNQVLDAYENK GIDYDKLIVR ISFPAIQAAPSFSNSFPQIFR MSASDPNSSIFLTDTAK PNSEPASLLELFNSIATQGELVR ADLSGMSGAR EATTNAPFR FAYGYIEDLK FQSLNADINKR HNSSGSILFLGR IEEQLTLEK IPELLASGMVDNMTK KIEEQLTLEK LGVQDLFNSSK LVLVNAIYFK TFHFNTVEEVHSR TYGADLASVDFQHASEDAR TYGADLASVDFQHASEDARK TYNFLPEFLVSTQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

59.3 82.9 35.1 40.3 29.7 39.3 48.1 51.8 93.6 53.3 42.7 42.1 51.7 53.9 76.7 153.0 74.8 72.6 60.5 41.4 28.0 43.2 46.6 47.5 66.3 114.0 30.1 38.8 35.6 53.9 59.7 107.0 93.8 56.8 57.6 109.0 135.0 68.3 30.0 51.7 63.6 49.4 43.3 92.8 30.2 74.2 32.0 20.2 102.0 55.1 64.6

18.9 20.1 19.5 22.5 20.9 23.3 21.1 20.0 21.8 21.1 19.8 15.8 17.1 19.9 22.6 21.3 21.5 22.4 22.6 22.9 20.0 23.0 14.3 24.0 22.5 22.7 21.8 15.3 20.5 22.0 16.4 21.3 19.4 20.3 21.5 21.6 20.7 21.0 23.3 23.3 22.3 23.3 22.4 22.7 21.7 23.3 14.0 22.3 19.9 20.7 22.7

2 3 2 2 0 2 2 3 9 2 2 2 1 4 21 7 6 2 1 1 0 3 5 1 5 4 1 1 2 2 5 11 4 2 2 9 2 6 1 2 4 1 2 9 1 11 4 0 2 0 11

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 1 6 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 4 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,365.60 1,333.75 1,354.76 1,168.60 2,416.10 1,232.61 908.50 1,022.46 1,731.90 1,811.94 915.56 853.53 2,143.18 1,601.88 1,263.60 1,930.00 1,351.75 1,419.75 1,690.83 1,390.69 1,127.66 865.45 997.59 961.50 1,338.64 1,762.89 1,098.54 1,209.72 1,167.66 1,404.70 1,801.03 1,800.87 1,455.64 1,191.67 2,325.20 1,800.83 2,485.29 964.45 1,006.50 1,218.60 1,305.69 1,287.68 1,102.60 1,650.81 1,230.69 1,207.63 1,179.71 1,602.77 2,052.93 2,181.02 1,686.87

Table S1 page 65/159

Cellular retinoic acid-binding protein RABP2_HUMAN CRABP2 2 Calmodulin

CALM_HUMAN CALM1

15,675

100.00%

3

3

5

16,820

100.00%

5

7

12

28.30% IAVAAASKPAVEIK SENFEELLK VGEEFEEQTVDGRPCK 50.30% DTDSEEEIREAFR EADIDGDGQVNYEEFVQMMTAK

Lysosomal protective protein

PPGB_HUMAN CTSA

54,450

100.00%

3

3

16

6.25%

Hornerin

HORN_HUMAN HRNR

282,355

100.00%

9

11

106

4.49%

Intercellular adhesion molecule 1

ICAM1_HUMAN ICAM1

57,807

100.00%

3

3

19

7.52%

Phosphoserine aminotransferase

SERC_HUMAN PSAT1

40,405

100.00%

9

11

33

24.10%

Scavenger mRNA-decapping enzyme DcpS Acylamino-acid-releasing enzyme

DCPS_HUMAN DCPS

38,592

99.90%

2

2

3

11.30%

ACPH_HUMAN APEH

81,206

100.00%

14

16

92

23.10%

EAFSLFDKDGDGTITTK ELGTVMR VFDKDGNGYISAAELR DTVVVQDLGNIFTR YEKDTVVVQDLGNIFTR YGDSGEQIAGFVK GPYESGSGHSSGLGHQESR GPYESGSGHSSGLGHR GSGSGQSPSSGQHGTGFGR GSGSGQSPSYGR HGSSSGSSSSYGQHGSGSR QSLGHGQHGSGSGQSPSPSR QSPSYGR SGSGWSSSR YGQQGSGSGQSPSR DGTFPLPIGESVTVTR LLGIETPLPK VELAPLPSWQPVGK ALELNMLSLK DDLLGFALR ELLAVPDNYK FGTINIVHPK FGVIFAGAQK GDDALEKR IINNTENLVR LPHSVLLEIQK QVVNFGPGPAK IVFENPDPSDGFVLIPDLK VNEASGDGDGEDAVVILEK AESFFQTK ALDVSASDDEIAR CELLSDDSLAVSSPR GSTGFGQDSILSLPGNVGHQDVK

MGFAVLLVNYR QPALSAACLGPEVTTQYGGQYR

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

HCDH_HUMAN HADH

34,260

100.00%

4

5

14

QVLLSEPEEAAALYR SALYYVDLIGGK SFNLSALEK TPLLLMLGQEDR TPLLLMLGQEDRR TVHTEWTQR VTSVVVDVVPR VVFDSAQR 12.10% DTPGFIVNR GDASKEDIDTAMK LVEVIK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

27.4 40.4 50.2 40.3 32.2 68.8 35.7 109.0 88.6 28.0 83.1 56.7 90.5 28.7 62.5 29.1 45.5 37.1 42.0 43.3 56.5 46.2 60.5 74.6 42.9 44.0 37.2 54.3 35.1 72.1 36.0 40.0 60.5 132.0 53.0 94.4 79.7 68.9 32.9 81.7 96.5 79.1 30.4 89.4 41.9 32.4 90.4 40.2 32.3 55.0 31.8

14.0 22.5 21.1 18.8 17.6 22.4 23.8 22.2 22.6 21.3 21.3 19.3 20.4 18.8 20.8 18.6 21.6 21.3 19.3 20.5 22.6 12.6 19.6 21.5 23.9 23.4 19.4 20.2 22.3 23.8 16.4 21.0 20.2 21.4 20.6 24.3 22.2 21.7 21.8 22.3 22.8 21.6 21.4 22.5 19.9 21.6 18.1 23.1 24.0 21.2 14.8

0 2 0 1 1 2 2 2 8 0 7 0 2 0 11 0 0 8 2 1 7 5 7 7 6 1 1 1 1 4 2 4 2 1 2 12 1 2 1 1 12 15 1 25 0 1 5 4 2 5 1

1 0 2 0 0 2 0 2 0 1 0 9 19 1 0 1 47 0 0 0 0 0 0 0 0 0 2 0 0 0 4 0 0 0 0 0 0 6 0 2 0 0 0 0 2 0 0 0 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,367.83 1,108.55 1,879.85 1,596.71 2,490.08 1,844.89 821.42 1,754.87 1,576.83 1,997.03 1,370.66 1,928.85 1,584.72 1,747.78 1,139.51 1,808.75 1,947.90 794.38 910.40 1,395.63 1,688.89 1,080.67 1,520.85 1,147.64 1,019.55 1,161.62 1,125.64 1,037.58 903.45 1,185.66 1,276.76 1,113.61 2,115.10 1,916.91 957.47 1,361.66 1,648.79 2,313.15 1,298.69 2,367.14 1,688.89 1,298.70 1,008.54 1,401.74 1,541.85 1,157.57 1,169.69 921.48 1,018.53 1,380.63 700.46

Table S1 page 66/159

Kinectin

KTN1_HUMAN KTN1

156,258

100.00%

30

33

68

Attractin

ATRN_HUMAN ATRN

158,518

100.00%

12

13

76

Fibroblast growth factor-binding protein 1

FGFP1_HUMAN FGFBP1

26,246

100.00%

5

7

160

CAD protein

PYR1_HUMAN CAD

242,965

100.00%

4

4

5

TFESLVDFSK 25.20% AHVQEVAQHNLK ALKEEIGNVQLEK AQQSLELIQSK DAVSNTTNQLESK EVIDLLKPDQVEGIQK GELTTLIHQLQEK ILNDQNK LLEEQLQHEISNK LMQLMESEQK LQALANEQAAAAHELEK LQQEEVQKK LQTLVSEQPNKDVVEQMEK NAEQAATQLK QMQSSFTSSEQELER QQNYQQASSFPPHEELLK QQQVEAVELEAK QSAELNK QTEDSLASER QTEDSLASERDR STYVTEVR SVEELLEAELLK SVEQEENKWK SVLAETEGILQK TAEHEAAQQDLQSK TENSSLTK TQLLQDVQDENK VQELQNLLK VQLQEAER WEEVQSYIR WLQDLQEENESLK 8.96% CTWLIEGQPNR DLDMFINASK EEYSNLKLPR IMQSSQSMSK LTGSSGFVTDGPGNYK LTLTPWVGLR NHNALLASLTTQK SEAACLAAGPGIR SVNNVVVR TLDHDR YDVDTQMWTILK YGHSLALYK 21.40% DTLGNTQIK KDFPESSLK LVSSTLFGNTKPR VVSEQKDTLGNTQIK WAATEQEEGISLK 2.20% EATAGNPGGQTVR LALGIPLPELR MALLATVLGR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

61.5 40.1 58.8 68.5 90.9 58.9 34.5 30.7 75.1 33.2 69.9 49.2 42.2 50.8 112.0 35.7 59.5 41.7 47.4 28.9 33.4 76.0 41.6 89.2 69.7 33.4 78.3 38.4 50.3 50.4 63.6 67.2 40.8 35.9 53.3 95.5 61.7 81.3 64.7 38.1 30.5 77.1 27.3 63.2 33.0 91.8 96.9 95.1 36.7 31.8 32.2

22.4 22.2 21.1 22.6 22.0 17.9 20.3 22.5 21.6 21.2 21.8 23.6 22.0 22.9 19.3 22.7 22.4 24.9 21.2 20.9 19.5 21.6 22.5 22.4 22.1 22.3 22.3 19.9 21.4 22.8 23.0 22.0 21.8 22.9 19.5 22.1 19.1 20.4 21.8 22.9 19.2 22.0 21.4 24.0 22.5 20.1 20.9 23.5 21.8 7.8 20.3

4 0 2 5 4 2 1 1 2 2 1 1 0 2 3 0 1 1 2 0 1 2 2 4 5 1 2 3 4 2 2 4 2 1 6 19 12 5 8 3 1 7 0 20 3 38 8 75 1 1 1

0 1 2 0 0 1 0 0 0 0 1 0 3 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 1 0 0 11 5 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,172.58 1,373.73 1,470.82 1,244.69 1,406.68 1,824.01 1,509.83 844.45 1,580.83 1,268.59 1,806.94 1,129.62 2,231.12 1,073.56 1,802.79 2,144.04 1,371.71 789.41 1,135.52 1,406.65 954.49 1,372.76 1,276.62 1,287.72 1,555.74 879.44 1,430.71 1,084.64 972.51 1,209.59 1,631.79 1,373.66 1,169.55 1,248.66 1,142.52 1,599.77 1,155.69 1,410.77 1,272.64 886.51 756.36 1,528.74 1,051.56 989.53 1,050.55 1,419.80 1,659.89 1,461.72 1,257.62 1,191.75 1,060.62

Table S1 page 67/159

Serum albumin

ALBU_HUMAN ALB

69,349

100.00%

23

27

1376

Transaldolase

TALDO_HUMAN TALDO1

37,524

100.00%

20

24

197

Actin-like protein 6A

ACL6A_HUMAN ACTL6A

47,443

100.00%

4

4

10

Protein S100-A2

S10A2_HUMAN S100A2

11,099

100.00%

4

5

8

VLGTSPEAIDSAENR 38.40% AACLLPK AAFTECCQAADK AVMDDFAAFVEK CCTESLVNR DDNPNLPR DVFLGMFLYEYAR FKDLGEENFK FQNALLVR KVPQVSTPTLVEVSR LKECCEKPLLEK LVAASQAALGL LVNEVTEFAK LVTDLTK QNCELFEQLGEYK QTALVELVK RHPDYSVVLLLR SLHTLFGDK TCVADESAENCDK TYETTLEK VFDEFKPLVEEPQNLIK VPQVSTPTLVEVSR YICENQDSISSK YLYEIAR 48.10% AAQASDLEK ALAGCDFLTISPK EAGISKDR FAADAVK IHLDEK ILDWHVANTDK ILDWHVANTDKK KFAADAVK KLGGSQEDQIK LGGSQEDQIK LIELYK LLGELLQDNAK LSDGIRK LSFDKDAMVAR LSSTWEGIQAGK MESALDQLK SYEPLEDPGVK TIVMGASFR VSTEVDAR WLHNEDQMAVEK 11.40% IPEGLFDPSNVK LIANNTTVER QGGPTYYIDTNALR VDFPTAIGMVVER 27.60% ELPSFVGEK ELPSFVGEKVDEEGLK VDEEGLKK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

98.5 36.6 53.6 68.9 53.0 32.7 39.2 52.4 53.2 104.0 56.1 69.3 64.2 55.6 75.9 54.3 39.1 32.1 96.6 34.8 58.5 84.9 51.9 46.6 68.2 83.2 47.0 49.4 33.2 65.4 64.2 31.2 32.9 56.5 46.9 77.8 46.9 62.5 88.6 43.9 36.0 37.7 59.2 61.3 31.1 55.6 74.9 41.6 36.6 86.8 40.1

22.7 24.7 14.6 20.8 18.1 22.0 22.3 22.8 19.8 16.1 22.5 17.6 22.8 21.1 21.1 21.2 17.6 23.9 8.5 21.1 20.0 20.3 19.4 21.0 23.6 22.4 24.5 23.0 18.8 22.7 20.2 20.6 23.9 23.9 13.8 21.3 22.2 22.7 23.3 23.1 22.6 22.3 23.6 21.5 22.9 23.8 22.6 22.8 21.9 22.6 23.6

2 11 4 22 36 3 2 8 38 264 11 2 44 70 2 9 0 1 3 1 17 88 52 194 4 13 5 3 1 2 5 1 1 8 9 45 4 12 24 8 6 14 10 10 1 4 4 1 1 2 2

0 0 0 0 0 0 0 4 0 444 4 0 0 0 0 0 8 0 0 0 34 0 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 2 0 0 0 0 0 7 0 0 0 0 0 1 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,558.77 772.44 1,371.57 1,342.64 1,138.50 940.45 1,639.78 1,226.61 960.56 1,639.94 1,546.80 1,013.60 1,149.62 789.47 1,657.75 1,000.60 1,467.84 1,017.54 1,498.58 984.49 2,045.10 1,511.84 1,443.64 927.49 932.47 1,392.72 875.46 721.39 754.41 1,311.67 1,439.76 849.48 1,202.64 1,074.54 778.47 1,213.68 788.46 1,252.64 1,276.65 1,050.51 1,233.60 981.52 876.44 1,499.70 1,315.69 1,130.62 1,568.77 1,433.75 1,005.53 1,775.91 917.49

Table S1 page 68/159

Peptidyl-prolyl cis-trans isomerase C PPIC_HUMAN PPIC

22,746

99.50%

2

2

14

Receptor-type tyrosine-protein phosphatase U

PTPRU_HUMAN PTPRU

162,407

100.00%

4

4

19

Transportin-3

TNPO3_HUMAN TNPO3

104,186

100.00%

2

3

6

Elongation factor 1-beta

EF1B_HUMAN EEF1B2

24,746

100.00%

3

3

19

Serine protease 23

PRS23_HUMAN PRSS23

42,984

100.00%

4

5

13

Soluble calcium-activated nucleotidase 1

CANT1_HUMAN CANT1

44,822

100.00%

7

7

24

Carcinoembryonic antigen-related cell adhesion molecule 1

CEAM1_HUMAN CEACAM1

57,542

100.00%

3

3

32

Brain-specific serine protease 4

BSSP4_HUMAN PRSS22

33,713

100.00%

3

3

22

Protein TFG

TFG_HUMAN TFG

43,430

99.50%

2

2

4

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

PIMT_HUMAN PCMT1

24,633

100.00%

5

5

9

Dickkopf-related protein 1

DKK1_HUMAN DKK1

28,653

100.00%

4

5

16

Apoptosis-associated speck-like protein containing a CARD

ASC_HUMAN PYCARD

21,610

100.00%

6

6

11

Tropomyosin alpha-4 chain

TPM4_HUMAN TPM4

28,504

100.00%

3

3

6

YSCQEGDKFK 9.91% IVIGLFGK TVENFVALATGEK 3.32% FLATFPLAAVSR GAPISVYQVIVEEER LVLTNPEGR QSGALVPAAGVR 3.90% SLDSFLLSPEAAVGLLK SVDPENNPTLVEVLEGVVR 18.20% KPALVAK LEECVR SIQADGLVWGSSK SPAGLQVLNDYLADK 17.20% DFLLNYPFSTSVK GNANDIGMDYDYALLELK LEVSSSCGPQCHK LPVVLPQSTLNLAKPDFGAEAK 23.20% AEWLAVKDER AQEENTWFSYLK AVPWVILSDGDGTVEK EWTTTTGDVVNENPEWVK GMELSDLIVFNGK TGVVYQIEGSK VASYIMAFTLDGR 8.94% QIVGYAIGTQQATPGPANSGR TIIVTELSPVVAKPQIK TLTLLSVTR 13.60% IVQGVQLR VGVAWVEPHPVYSWK VVGGEDSTDSEWPWIVSIQK 9.75% LLDSLEPPGEPGPSTNIPENDTVDGREEK LLSNDEVTIK 33.50% ALDVGSGSGILTACFAR LILPVGPAGGNQMLEQYDK MKPLMGVIYVPLTDKEK SGGASHSELIHNLR VQLVVGDGR 12.00% GQEGSVCLR GSHGLEIFQR KGSHGLEIFQR SSDCASGLCCAR 27.20% DLLLQALR ESQSYLVEDLER ESQSYLVEDLERS LLSVPLR VLTDEQYQAVR VTNVEWLLDALYGK 39.90% AEFAER AEVSELK EKAEGDVAALNR HIAEEADR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

35.1 40.9 106.0 56.1 97.5 37.6 38.1 47.6 74.4 39.0 37.8 70.8 120.0 54.7 80.6 52.0 73.4 31.4 57.8 98.1 102.0 37.6 54.8 62.0 113.0 37.0 64.0 40.8 57.7 84.2 38.7 65.8 57.6 59.4 29.3 48.3 33.2 33.3 41.5 41.1 40.7 39.9 65.9 57.8 30.0 84.0 61.8 30.5 33.9 63.8 38.5

18.4 9.5 22.2 18.9 22.6 18.8 19.3 17.5 20.2 12.0 22.9 22.5 22.6 22.5 20.6 19.0 14.0 23.4 21.1 22.2 21.3 22.9 22.5 23.4 22.1 9.5 13.2 15.2 21.9 21.5 19.9 23.0 22.4 21.4 20.0 23.5 20.0 22.2 22.7 21.7 9.0 16.5 22.5 21.0 12.3 22.6 21.2 22.0 25.1 22.7 22.0

2 2 12 9 6 1 3 2 2 1 1 6 12 4 4 2 2 1 3 9 4 1 4 2 6 1 25 9 0 6 0 2 2 2 0 0 1 2 2 0 3 2 2 2 1 2 2 1 1 2 4

0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 7 0 2 0 0 0 2 2 0 0 3 6 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,261.55 846.55 1,378.72 1,292.74 1,688.89 998.56 1,125.64 1,759.98 2,066.08 726.49 805.39 1,347.69 1,603.83 1,530.78 2,030.94 1,488.66 2,308.29 1,216.63 1,515.71 1,685.88 2,104.98 1,438.73 1,180.62 1,459.73 2,086.07 1,836.12 1,003.62 912.56 1,753.91 2,232.08 3,105.49 1,131.63 1,694.85 2,059.05 1,994.07 1,477.75 942.54 1,005.48 1,143.59 1,271.69 1,343.51 941.58 1,467.70 1,554.73 797.53 1,321.68 1,620.86 722.35 775.42 1,272.65 940.45

Table S1 page 69/159

Phosphoglycerate kinase 1

PGK1_HUMAN PGK1

44,597

100.00%

32

45

935

IQALQQQADEAEDR IQLVEEELDR IQLVEEELDRAQER KYEEVAR LEEAEKAADESER LKEAETR LVILEGELER RIQLVEEELDR YEEVAR 72.90% ACANPAAGSVILLENLR AGGFLMK AHSSMVGVNLPQK ALESPERPFLAILGGAK ALMDEVVK DCVGPEVEK DVLFLK ELNYFAK FHVEEEGKGK IQLINNMLDK IQLINNMLDKVNEMIIGGGMAFTFLK

ITLPVDFVTADK ITLPVDFVTADKFDENAK KYAEAVTR LGDVYVNDAFGTAHR LTLDKLDVK NNQITNNQR SLLGKDVLFLK SVVLMSHLGRPDGVPMPDK SVVLMSHLGRPDGVPMPDKYSLEPVAVELK

TGQATVASGIPAGWMGLDCGPESSK TGQATVASGIPAGWMGLDCGPESSKK

VADKIQLINNMLDK VDFNVPMK VDFNVPMKNNQITNNQR VLNNMEIGTSLFDEEGAK VLPGVDALSNI VNEMIIGGGMAFTFLK VSHVSTGGGASLELLEGK WNTEDKVSHVSTGGGASLELLEGK

Junctional adhesion molecule A

JAM1_HUMAN F11R

Procollagen-lysine,2-oxoglutarate 5- PLOD1_HUMAN PLOD1 dioxygenase 1

32,565

100.00%

6

6

27

83,535

100.00%

18

18

85

YAEAVTR YSLEPVAVELK 22.70% DGIVMPTNPK FDQGDTTR IPENNPVK ITASYEDR LIVLVPPSKPTVNIPSSATIGNR VTFLPTGITFK 33.40% AQVEEFLAQHGSEYQSVK FLGSGGFIGYAPNLSK FLLEYIAPMTEK IFLDPEKR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

75.6 69.4 50.9 30.6 77.8 42.4 41.3 32.9 38.1 106.0 51.7 64.1 82.0 51.0 49.2 42.5 38.3 36.8 52.5 50.3 54.8 100.0 51.4 105.0 45.5 52.8 44.0 42.9 26.2 80.3 50.2 70.8 55.8 40.3 101.0 66.6 76.2 106.0 61.5 53.1 65.8 30.8 43.3 38.2 51.5 45.7 40.0 94.9 107.0 69.9 38.1

21.9 22.3 21.9 22.4 21.9 24.5 20.3 21.9 22.0 20.4 22.2 22.6 17.3 23.9 18.8 15.7 21.5 22.2 23.4 20.0 20.3 21.4 20.8 22.5 17.3 21.5 9.0 22.4 18.5 20.3 21.4 21.0 22.8 22.7 22.0 18.7 22.5 21.6 21.1 22.5 21.6 22.0 18.6 19.6 20.6 4.8 16.8 22.3 21.9 22.4 21.9

3 10 7 1 11 6 2 2 3 5 22 24 38 7 10 2 6 3 6 0 1 67 2 25 6 15 2 0 0 1 0 4 13 2 153 39 40 47 0 25 22 1 3 5 5 0 4 6 5 7 1

0 0 6 0 7 0 0 2 0 1 0 10 52 0 0 0 0 18 0 3 0 40 0 76 0 0 0 8 0 2 5 4 0 2 4 0 1 77 33 0 0 0 0 0 0 9 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,614.77 1,243.65 1,727.89 894.47 1,476.68 846.47 1,170.67 1,399.75 766.37 1,768.94 739.38 1,383.71 1,769.00 904.48 1,032.47 734.45 884.45 1,159.57 1,217.66 2,958.51 1,318.73 2,023.04 937.51 1,634.79 1,044.63 1,101.54 1,232.76 2,035.05 3,295.71 2,493.14 2,621.23 1,630.88 965.48 2,048.00 1,966.94 1,097.62 1,759.88 1,740.91 2,514.25 809.42 1,247.69 1,087.55 939.42 910.50 954.45 2,373.39 1,223.70 2,049.99 1,627.85 1,470.76 1,017.57

Table S1 page 70/159

Threonyl-tRNA synthetase, cytoplasmic

SYTC_HUMAN TARS

83,420

100.00%

33

37

191

IFQNLDGALDEVVLK IQALGLGEDWNVEK IQGGYENVPTIDIHMNQIGFER LDPDMAFCANIR LQLNYLGNYIPR LVAEWEGQDSDSDQLFYTK LVGPEVR NLAYDTLPVLIHGNGPTK NVIAPLMTR QQDVFMFLTNR SAQFFNYK SEDYVDIVQGR SQVVFSAEELIYPDR VGVWNVPYISNIYLIK 45.50% ADMETLQR AEHDSILAEK AELNPWPEYIYTR AILGSVER CGPLIDLCR ETLLAMFK FLGDIEVWDQAEK FNLTYVSHDGDDK FQEEAK GAYIYNALIEFIR GCLDFLR GFQEVVTPNIFNSR IDIQIK IYGISFPDPK KETLLAMFK LADFGVLHR LEMYNILK LNLSTRPEK MGGEEKPIGAGEEK MIAILTENYGGK NELSGALTGLTR NSSTYWEGK QLENSLNEFGEK QLENSLNEFGEKWELNSGDGAFYGPK

Nuclear mitotic apparatus protein 1

NUMA1_HUMAN NUMA1

238,242

100.00%

6

6

10

QVDAESWK QVMVVPVGPTCDEYAQK TISETIER TTPYQIACGISQGLADNTVIAK TVYSVFGFSFK VNTPTTTVYR VTLPDGK WELNSGDGAFYGPK WPFWLSPR 3.55% AALMESQGQQQEER ALQQVQEK AVQAQGGESQQEAQR DSALETLQGQLEEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0%

109.0 88.5 54.3 77.1 67.4 74.0 33.1 89.7 30.2 62.6 36.1 82.0 40.8 50.0 64.4 49.9 57.3 56.8 60.3 42.7 68.7 67.1 32.3 78.3 31.5 71.8 32.3 63.7 37.6 60.4 39.0 32.9 59.1 62.2 97.8 39.7 67.8 90.1 41.4 67.5 39.7 103.0 35.9 38.7 32.5 60.9 46.6 67.6 30.1 86.3 48.0

20.5 21.3 21.5 20.8 20.7 21.1 17.2 19.8 23.4 22.7 22.6 22.3 22.0 16.1 22.0 21.4 22.7 23.7 22.5 20.7 22.7 19.6 23.2 20.9 23.2 23.2 20.5 22.2 19.7 20.3 21.1 22.2 20.6 22.5 22.5 18.9 22.1 20.1 21.3 21.8 23.8 20.9 22.7 22.5 21.1 20.8 23.9 19.7 20.6 22.2 23.0

13 4 0 2 7 11 2 3 1 8 1 8 1 1 6 5 8 3 2 4 13 2 1 9 1 12 2 25 2 2 3 0 10 6 17 2 2 0 3 4 5 4 2 1 3 2 11 4 1 1 1

0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 1 0 0 2 8 0 0 0 0 4 0 0 0 2 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,673.91 1,571.81 2,531.24 1,438.65 1,463.80 2,231.01 769.46 1,923.03 1,030.57 1,398.68 1,004.48 1,280.61 1,752.88 1,878.05 963.46 1,112.56 1,651.81 844.49 1,103.53 968.51 1,549.75 1,510.68 751.36 1,542.83 880.44 1,607.82 729.45 1,136.60 1,080.61 1,027.57 1,023.56 1,057.60 1,447.67 1,309.68 1,231.66 1,071.47 1,407.68 2,929.36 962.46 1,936.92 948.50 2,321.18 1,281.65 1,151.61 729.41 1,540.71 1,088.57 1,620.73 943.52 1,586.75 1,560.78

Table S1 page 71/159

Disintegrin and metalloproteinase domain-containing protein 15 von Willebrand factor A domaincontaining protein 1

ADA15_HUMAN ADAM15

87,726

99.50%

2

2

4

VWA1_HUMAN VWA1

46,786

100.00%

4

4

5

Eukaryotic translation initiation factor 3 subunit I

EIF3I_HUMAN EIF3I

36,484

100.00%

4

4

7

Epithelial discoidin domaincontaining receptor 1 Septin-7

DDR1_HUMAN DDR1

101,112

99.90%

2

2

5

SEPT7_HUMAN SEPT7

50,662

100.00%

6

6

13

Tropomyosin alpha-3 chain

TPM3_HUMAN TPM3

32,802

100.00%

4

4

15

36,244

99.50%

2

2

3

71,827

100.00%

3

3

7

DSAQTSVTQAQR LLQAETASNSAR 3.69% SYTLEQGPGDLQGPPIISR VLQTSLPEPLR 15.70% EFVGQLVAPLPLGTGALR EQLFAEASGARPGVPK MGDTHTGLALVYAK VLVWVTDGGSSDPVGPPMQELK

Four and a half LIM domains protein FHL1_HUMAN FHL1 1 TNR21_HUMAN TNFRSF21 Tumor necrosis factor receptor superfamily member 21 Importin-9

IPO9_HUMAN IPO9

115,946

99.90%

2

2

3

Collagen alpha-1(VII) chain

CO7A1_HUMAN COL7A1

295,200

100.00%

14

15

84

13.80% DPSQIDNNEPYMK LFDSTTLEHQK QINDIQLSR SYSSGGEDGYVR 2.19% DRWGQEVISGNEDPEGVVLK WGQEVISGNEDPEGVVLK 15.30% DVTNNVHYENYR FEDYLNAESR NLEGYVGFANLPNQVYR SPLAQMEEERR TVQVEQSK VNIIPLIAK 34.50% AADAEAEVASLNR AEFAER HIAEEADR IQLVEEELDR IQLVEEELDRAQER KLVIIEGDLER KYEEVAR LDKENALDR LEEAEKAADESER LKEAETR MELQEIQLK RIQLVEEELDR YEEVAR 7.12% AIVAGDQNVEYK QVIGTGSFFPK 5.19% GPEASLAQLISALR GTETEDVR GTFSDVPSSVMK 3.27% EALVDTLTGILSPVQEVR YSNDPVVASLAQDIFK 6.56% DLVLSEPSSQSLR EGSASVLTVR FATVQYSDDPR GATGVQGER GPGQEVPGSPQTLPGISSSQR LSVLGPAGEGPSAEVTAR QEVNVPAGETSVR SFLEGLVLPFSGAASAQGVR SQDLVDTAAQR VLSGGPTQQQELGPGQGSVLLR VPSIELR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

38.2 40.5 74.7 31.0 38.0 29.0 31.6 69.8 51.0 44.7 34.4 54.2 42.2 92.0 71.4 66.7 61.7 26.4 33.8 39.9 60.6 30.5 38.5 69.4 50.9 41.8 30.6 32.3 77.8 42.4 56.2 32.9 38.1 44.2 36.8 50.8 33.1 45.8 48.8 38.1 54.3 37.2 37.3 41.6 73.3 70.1 59.4 55.8 56.4 89.5 36.3

22.6 23.3 21.0 17.7 15.6 21.8 22.7 21.4 16.6 23.1 22.0 16.7 21.7 22.2 20.9 20.3 21.6 24.2 23.7 9.5 21.8 22.0 22.0 22.3 21.9 18.3 22.4 23.4 21.9 24.5 23.9 21.9 22.0 23.2 21.6 19.3 21.1 21.4 18.5 21.8 21.8 23.4 20.8 21.7 22.6 21.0 22.3 19.7 23.2 19.5 17.9

2 1 3 1 2 0 0 1 2 2 1 2 0 4 2 2 1 0 1 6 5 1 4 10 7 1 1 0 11 6 5 2 3 2 1 2 2 3 2 1 9 1 2 1 6 14 13 1 11 4 3

0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 6 0 0 2 7 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,291.62 1,260.65 2,028.04 1,252.73 1,838.05 1,656.87 1,492.75 2,327.16 1,566.67 1,318.66 1,086.59 1,276.54 2,227.10 1,955.97 1,523.69 1,243.56 1,953.98 1,361.65 918.49 980.65 1,316.64 722.35 940.45 1,243.65 1,727.89 1,284.75 894.47 1,073.56 1,476.68 846.47 1,131.61 1,399.75 766.37 1,306.66 1,180.64 1,425.81 906.42 1,270.60 1,940.07 1,766.90 1,430.75 1,018.55 1,298.60 874.44 2,079.05 1,710.90 1,385.70 2,006.07 1,203.60 2,221.19 813.48

Table S1 page 72/159

Alpha-mannosidase 2

MA2A1_HUMAN MAN2A1

131,128

100.00%

10

10

21

Phosphoglycerate kinase 2

PGK2_HUMAN PGK2

44,779

99.50%

2

2

13

Glucose-6-phosphate isomerase

G6PI_HUMAN GPI

63,130

100.00%

23

29

381

VQYTPLTGLGQPLPSER VSWSPVPGATQYR VVVSDATR 10.50% FLSSSLYTALTEAR FYTDLNGYQIQPR GLEQGIQDNK ILESASSNSHLADYVLYK ITANLFR LLAENNEIISNIR NYQQLFDYMNSQSK SQDSLPQK VLLAPLGDDFR YLVVYNPLEQDR 19.70% DVLFLK LGDVYVNDAFGTAHR NQITNNQR SLLGKDVLFLK VDFNVPMK VNEMIIGGGMAYTFLK VSHVSTGGGASLELLEGK WNTEDKVSHVSTGGGASLELLEGK

42.50% AVLHVALR DPQFQK DVMPEVNK ELQAAGK EWFLQAAK FAAYFQQGDMESNGK HFVALSTNTTK ILLANFLAQTEALMR INYTEGR KELQAAGK KIEPELDGSAQVTSHDASTNGLINFIK

LFDANKDR LTPFMLGALVAMYEHK MLVDLAK NLVTEDVMR SELNLR SNTPILVDGKDVMPEVNK SPEDLER TFTTQETITNAETAK TFTTQETITNAETAKEWFLQAAK

AN32A_HUMAN ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A

28,568

100.00%

10

11

42

TLAQLNPESSLFIIASK VFEGNRPTNSIVFTK VWYVSNIDGTHIAK 35.70% CPNLTHLNLSGNK DLSTIEPLK ELVLDNSR IKDLSTIEPLK KLELSDNR LLPQLTYLDGYDR LLPQLTYLDGYDRDDK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

95.4 45.1 40.4 82.8 42.7 51.1 30.9 30.5 75.2 66.6 33.2 42.6 46.4 42.5 105.0 32.9 44.0 55.8 46.3 106.0 61.5 41.5 35.9 31.9 33.0 48.4 86.3 55.4 97.3 39.8 45.9 51.9 33.3 56.9 37.7 52.5 33.3 58.6 48.9 119.0 66.2 108.0 42.3 72.5 39.5 33.0 41.8 50.2 51.6 69.2 35.1

19.9 23.4 24.5 23.2 22.2 22.2 21.5 21.8 21.3 20.0 22.5 22.0 23.0 15.7 22.5 20.9 9.0 22.8 22.5 21.6 21.1 9.0 23.3 22.3 23.6 23.1 19.3 23.1 19.2 22.7 23.7 19.2 24.0 21.9 21.0 22.6 25.1 22.3 19.5 21.9 21.1 16.8 21.4 22.8 23.2 21.5 23.2 17.5 22.8 21.9 22.8

12 3 2 2 2 4 0 1 4 1 1 3 2 2 25 1 2 13 12 47 0 3 4 1 1 12 6 10 69 7 3 0 2 4 4 12 5 8 15 69 1 57 6 14 0 3 5 6 3 4 1

0 0 0 0 0 0 1 0 0 0 0 0 0 0 76 0 0 0 0 77 33 0 0 0 0 0 0 0 28 0 0 16 0 0 0 0 0 7 0 1 8 2 0 6 2 0 0 3 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,855.99 1,447.73 846.47 1,558.81 1,614.79 1,101.55 2,010.02 834.48 1,498.82 1,781.78 902.46 1,215.67 1,508.78 734.45 1,634.79 987.50 1,232.76 965.48 1,759.88 1,740.91 2,514.25 878.56 762.38 947.45 716.39 992.52 1,692.73 1,218.65 1,719.95 852.42 844.49 2,884.47 978.50 1,852.93 805.45 1,092.54 731.41 1,972.01 845.40 1,655.81 2,629.32 1,832.02 1,708.90 1,602.83 1,467.74 1,015.57 945.50 1,256.75 974.53 1,566.82 1,924.97

Table S1 page 73/159

Hypoxia up-regulated protein 1

HYOU1_HUMAN HYOU1

111,319

100.00%

4

4

7

Phosphoglycolate phosphatase

PGP_HUMAN PGP

33,989

100.00%

3

3

6

14-3-3 protein beta/alpha

1433B_HUMAN YWHAB

28,065

100.00%

7

11

180

SLDLFNCEVTNLNDYR TPSDVKELVLDNSR VSGGLEVLAEK 5.81% AANSLEAFIFETQDK DAVVYPILVEFTR LGNTISSLFGGGTTPDAK LPATEKPVLLSK 11.80% GETAVPGAPEALR LGFITNNSSK TILTLTGVSTLGDVK 63.00% AVTEQGHELSNEER DNLTLWTSENQGDEGDAGEGEN

Biliverdin reductase A

BIEA_HUMAN BLVRA

33,411

100.00%

4

4

11

Ras-related protein Rab-10

RAB10_HUMAN RAB10

22,524

99.50%

2

2

4

Plectin-1

PLEC1_HUMAN PLEC1

531,766

100.00%

106

109

722

DSTLIMQLLR EMQPTHPIR KEMQPTHPIR LAEQAER LAEQAERYDDMAAAMK NLLSVAYK NLLSVAYKNVVGAR QTTVSNSQQAYQEAFEISK QTTVSNSQQAYQEAFEISKK TAFDEAIAELDTLNEESYK VISSIEQK YDDMAAAMK YLIPNATQPESK YLSEVASGDNK 16.20% FGFPAFSGISR GSLLFTAGPLEEER SGSLENVPNVGVNK SPLSWIEEK 22.50% AFLTLAEDILR LLLIGDSGVGK LQIWDTAGQER NIDEHANEDVER 24.20% AALAHSEEVTASQVAATK AALEEVER AGVAAPATQVAQVTLQSVQR AGVVGPELHEQLLSAEK AKLEQLFQDEVAK ALQALEELR APVPASELLASGVLSR AQAEQAALR AQLEPVASPAK AQVEQELTTLR ASDSELER DDGTGQLLLPLSDAR DPYSGSTISLFQAMQK DSQDAGGFGPEDR DTHDQLSEPSEVR EAEGQLQK EAQAVPATLPELEATK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

103.0 27.4 78.7 46.8 41.9 55.3 46.6 36.5 39.2 65.0 105.0 122.0 79.3 67.1 43.9 59.4 52.0 51.4 79.1 140.0 78.3 96.7 65.9 70.3 71.3 76.9 53.9 44.2 61.4 36.6 49.9 58.7 61.5 38.0 28.9 52.1 78.0 26.4 53.2 59.2 112.0 53.9 48.8 75.7 57.2 57.4 88.4 61.0 46.5 36.2 53.1

20.7 22.2 22.9 22.5 20.6 21.9 14.0 21.9 21.7 16.8 21.6 14.3 21.3 22.4 22.5 21.6 20.8 19.1 17.7 22.0 22.2 21.5 22.9 14.5 23.7 21.7 22.0 23.0 21.6 23.1 20.6 20.3 22.2 18.6 21.5 22.2 17.1 20.9 22.0 21.5 18.0 21.1 19.8 23.1 21.1 22.0 21.8 14.9 21.2 22.5 19.9

5 0 8 0 2 1 2 1 2 3 27 4 113 13 0 36 4 49 4 65 2 14 27 11 14 26 2 3 4 2 3 2 7 1 0 7 2 0 2 14 22 2 5 13 5 6 3 13 1 5 5

0 2 0 2 0 0 0 0 0 0 9 0 0 0 11 0 1 0 2 2 11 6 0 0 0 0 0 0 0 0 0 0 0 0 1 0 10 1 0 0 1 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,972.91 1,572.82 1,101.62 1,683.82 1,521.83 1,735.89 1,295.79 1,267.66 1,080.57 1,517.88 1,598.74 2,350.96 1,189.66 1,108.56 1,252.65 816.42 1,812.83 907.53 1,503.86 2,159.03 2,287.12 2,159.00 903.52 1,015.42 1,360.71 1,182.56 1,185.61 1,518.78 1,413.73 1,088.56 1,261.72 1,071.64 1,316.66 1,440.64 1,783.92 916.47 1,995.10 1,776.95 1,518.82 1,042.59 1,566.89 957.51 1,110.62 1,287.69 906.42 1,570.81 1,772.85 1,350.56 1,512.69 902.46 1,667.89

Table S1 page 74/159

ELAQEQAR ELQNAGDR EQELQQTLQQEQSVLDQLR ESADPLGAWLQDAR FLEVQYLTGGLIEPDTPGR FPVTDAVNK FRELAEEAAR GAQEVGER GGAEGELQALR GGELVYTDSEAR GIYQSLEGAVQAGQLK GKAEEQAVR GTQGAEEVLR GYFSEEMNR GYYSPYSVSGSGSTAGSR HISDLYEDLR LAAEQELIR LAAIGEATR LAEDEAFQR LEDLLQDAQDEKEQLNEYK LEQLFQDEVAK LFNAIIHR LGFHLPLEVAYQR LISLFQAMK LKQSAEEQAQAR LLDAQLATGGIVDPR LLDPEDVDVPQPDEK LLEAAAQSTK LLFNDVQTLK LLLWSQR LQAEEAER LQAEEVAQQK LQEAGILSAEELQR LQEALR LQLEATER LQNVQIALDYLR LRAETEQGEQQR LSVAAQEAAR LSYTQLLR LTAEDLFEAR LVASMEEAR MQAVQEATR MQEEVVR NDDIADGNPK NLLDEELQR NLVDNITGQR QAEEIGEK QEQIQAMPLADSQAVR QLAAEEER QLAEEDAAR QLAEEDLAQQR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

56.9 50.4 124.0 87.9 84.1 31.8 29.4 59.1 90.5 59.1 81.3 34.5 40.6 35.0 81.6 39.1 40.0 46.2 64.9 48.9 49.6 54.7 29.5 36.1 60.9 59.4 82.8 46.5 53.8 41.9 46.6 48.4 87.2 32.0 41.5 77.8 54.8 65.2 62.8 59.6 42.4 62.2 42.9 55.8 53.1 54.5 40.1 69.7 45.4 65.0 75.8

21.0 20.8 21.4 22.0 21.2 23.3 23.7 20.7 22.5 22.2 21.0 22.4 22.1 12.6 19.0 22.0 20.1 24.1 22.7 21.5 23.0 16.0 21.1 19.7 22.9 19.1 22.5 23.3 20.0 20.3 20.1 23.0 22.2 23.3 22.5 19.2 22.7 22.4 17.2 23.5 22.5 22.1 22.2 17.6 23.2 23.0 22.1 21.3 20.1 20.0 21.9

14 5 6 29 4 2 0 5 11 2 6 1 2 1 1 2 2 11 13 0 1 4 0 1 0 4 11 3 6 5 8 16 4 1 3 4 6 5 3 4 3 11 5 7 6 2 4 1 6 7 19

0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 1 0 17 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

944.48 902.43 2,313.17 1,528.74 2,105.09 990.53 1,191.61 845.41 1,100.57 1,296.61 1,661.89 987.52 1,059.54 1,148.47 1,782.79 1,260.62 1,042.59 901.51 1,078.52 2,321.12 1,319.68 983.58 1,542.84 1,050.60 1,358.70 1,538.85 1,708.83 1,031.57 1,190.68 915.54 945.46 1,143.60 1,556.83 729.43 959.52 1,445.81 1,444.71 1,015.55 993.57 1,164.59 1,021.50 1,049.51 906.44 1,058.48 1,129.59 1,129.60 903.44 1,800.89 945.46 1,002.49 1,300.65

Table S1 page 75/159

Hypoxanthine-guanine phosphoribosyltransferase

HPRT_HUMAN HPRT1

24,562

100.00%

8

8

32

Receptor-type tyrosine-protein phosphatase S

PTPRS_HUMAN PTPRS

217,075

100.00%

4

4

12

Malate dehydrogenase,

MDHM_HUMAN MDH2

35,486

100.00%

17

21

365

QLAEGTAQQR QLEMSAEAER QLLEEELAR QLQLAQEAAQK QLQLAQEAAQKR QQEELLAEENQR QQGLASYDYVR QSAEEQAQAR QSSEAEIQAK QTNLENLDQAFSVAER QVAEEAAR QVEEEILALK QVQVALETAQR RAAEEAEEAR RPELEDSTLR RQELEAELAK RQEQIQAMPLADSQAVR SAEAELQSK SELELTLGK SIITYVSSLYDAMPR SIQEELQQLR SKEQAELEAAR SLAAEEEAAR SLESLHSFVAAATK SLQEEHVAVAQLR SLSAIYLEK SLVPAAELLESR SMVEEGTGLR SNAEDTLR SQVEEELFSVR SSIAGLLLK SWSLATFR VAQLLER VKAEAEAAR VLALPEPSPAAPTLR VPDVQDGVR VQSGSESVIQEYVDLR WQAVLAQTDVR 39.40% FFADLLDYIK NVLIVEDIIDTGK SIPMTVDFIR SYCNDQSTGDIK TMQTLLSLVR VASLLVK VFIPHGLIMDR VIGGDDLSTLTGK 2.77% SPQGLGAFTPVVR TDEDVPSAPPR TGEQAPASAPR VLAFTSVGDGPLSDPIQVK 62.70% AGAGSATLSMAYAGAR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

64.7 53.5 40.4 74.8 45.3 85.0 38.6 48.9 61.3 134.0 38.6 64.6 46.3 35.6 41.9 33.1 46.7 63.2 33.4 63.7 75.4 37.1 72.1 83.3 40.4 40.7 45.9 47.4 46.2 86.4 46.9 37.6 46.6 38.8 58.3 34.3 101.0 61.0 60.9 72.9 32.0 45.5 64.5 32.6 41.0 93.2 53.6 32.6 66.8 85.9 112.0

20.5 20.4 23.1 21.7 20.3 22.1 21.7 20.4 23.7 23.6 21.8 22.7 22.9 20.5 23.3 22.4 22.1 23.5 22.0 21.8 22.3 23.3 22.1 22.6 22.1 19.4 21.1 21.3 22.5 22.9 15.8 22.9 20.7 23.1 16.7 21.3 22.5 23.2 22.4 21.2 23.2 16.6 19.8 19.1 20.5 22.6 20.7 21.5 22.4 20.3 22.0

12 9 8 12 1 5 2 2 6 16 6 15 5 1 4 2 0 15 1 9 18 0 24 4 0 5 4 2 3 9 7 4 4 3 22 2 6 16 5 4 2 2 9 2 0 3 2 1 6 3 74

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 6 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,101.57 1,179.53 1,100.60 1,227.67 1,383.77 1,486.71 1,299.63 1,117.52 1,090.54 1,834.89 873.44 1,171.66 1,242.68 1,131.54 1,215.63 1,186.64 1,956.99 962.48 989.55 1,731.86 1,243.66 1,231.63 1,046.51 1,460.77 1,479.79 1,023.57 1,284.72 1,094.52 905.43 1,322.66 901.57 967.50 828.49 944.52 1,531.89 984.51 1,808.90 1,286.69 1,244.66 1,428.80 1,178.62 1,387.58 1,161.67 729.49 1,297.71 1,275.68 1,328.73 1,183.56 1,084.54 1,943.05 1,454.71

Table S1 page 76/159

mitochondrial

Protein jagged-1

JAG1_HUMAN JAG1

133,778

100.00%

8

9

26

ANTFVAELK FVFSLVDAMNGK GCDVVVIPAGVPR GYLGPEQLPDCLK HGVYNPNK IFGVTTLDIVR IQEAGTEVVK KGEDFVK LTLYDIAHTPGVAADLSHIETK MISDAIPELK SQETECTYFSTPLLLGK TIIPLISQCTPK VAVLGASGGIGQPLSLLLK VDFPQDQLTALTGR VNVPVIGGHAGK VSSFEEK 7.96% ASHSGMINPSR CVCPPQWTGK DDGNPIKEITDK DLVNDFYCDCK IIDLVSKR SSSLQPVK VTAGGPCSFGSGSTPVIGGNTFNLK

YISSNVCGPHGK Cadherin-3

Cytoplasmic aconitate hydratase

CADH3_HUMAN CDH3

ACOC_HUMAN ACO1

91,401

98,383

100.00%

100.00%

6

9

7

11

58

24

14.70%

DPAGWLAMDPDSGQVTAVGTLDREDEQFVR

ETGWLLLNKPLDREEIAK GLDFEAK IFYSITGPGADSPPEGVFAVEK LTVTDLDAPNSPAWR STGTISVISSGLDR YEAHVPENAVGHEVQR 17.40% FVEFFGPGVAQLSIADR GPFLLGIK IDFEKEPLGVNAK IETVNESWNALATPSDK QAPQTIHLPSGEILDVFDAAER SNLVGMGVIPLEYLPGENADALGLTGQER

Elongation factor 2

EF2_HUMAN

EEF2

95,322

100.00%

25

27

126

SPPFFENLTLDLQPPK VILQDFTGVPAVVDFAAMR YQQAGLPLIVLAGK 31.90% ALLELQLEPEELYQTFQR ARPFPDGLAEDIDKGEVSAR CLYASVLTAQPR EDLYLKPIQR EGIPALDNFLDKL FSVSPVVR GEGQLGPAER GGGQIIPTAR GHVFEESQVAGTPMFVVK GPLMMYISK IKPVLMMNK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8%

83.3 87.8 71.3 54.5 39.7 66.0 46.8 48.3 99.3 72.9 106.0 65.3 129.0 108.0 52.3 35.8 45.4 36.2 34.9 75.6 40.6 58.8 98.7 52.0 56.6 29.2 41.4 123.0 77.7 96.4 67.3 74.2 44.1 52.5 84.6 38.2 30.1 67.1 99.2 65.1 94.1 60.9 55.6 35.8 69.5 35.2 46.4 38.3 39.9 63.4 26.4

21.7 22.4 21.4 23.2 21.1 17.3 23.5 22.4 18.9 23.6 22.1 19.9 3.0 22.9 17.7 21.5 20.7 18.2 22.6 13.2 17.1 23.4 22.1 21.3 19.3 17.6 23.6 21.3 21.7 21.8 23.4 21.3 21.2 22.6 22.1 20.8 20.5 21.3 21.0 14.9 20.8 22.1 22.5 19.9 22.4 20.6 21.1 20.3 22.4 22.0 22.0

15 11 5 6 2 36 9 2 2 24 3 2 61 32 9 4 2 2 0 6 2 6 2 2 0 0 2 16 13 22 0 2 3 2 2 0 0 2 2 3 3 0 2 1 24 2 10 4 0 8 0

0 0 0 0 0 0 0 0 50 0 0 0 2 0 15 0 3 0 1 0 0 0 0 0 1 2 0 0 0 0 2 0 0 2 0 3 1 0 2 0 1 3 0 0 0 0 0 0 2 0 1

0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

992.54 1,343.67 1,338.72 1,489.74 928.46 1,233.72 1,073.58 822.44 2,365.24 1,116.60 1,973.95 1,370.77 1,793.09 1,560.80 1,147.66 825.40 1,172.55 1,232.56 1,344.67 1,448.58 943.59 845.47 2,425.18 1,318.62 3,291.52 2,125.17 779.39 2,281.14 1,655.84 1,392.73 1,834.88 1,852.96 844.53 1,459.78 1,874.91 2,407.23 3,029.53 1,842.96 2,065.08 1,470.87 2,220.16 2,143.08 1,378.72 1,274.71 1,444.77 890.51 1,013.50 969.55 1,977.97 1,055.53 1,089.62

Table S1 page 77/159

IMGPNYTPGKK IWCFGPDGTGPNILTDITK KEDLYLKPIQR KIWCFGPDGTGPNILTDITK MVNFTVDQIR QFAEMYVAK SDPVVSYR TFCQLILDPIFK TGTITTFEHAHNMR VFDAIMNFK VFSGLVSTGLK VNFTVDQIR WLPAGDALLQMITIHLPSPVTAQK

Cullin-associated NEDD8dissociated protein 1

CAND1_HUMAN CAND1

136,363

100.00%

12

12

26

Proteasome subunit beta type-8

PSB8_HUMAN PSMB8

30,337

100.00%

6

7

15

Exostosin-2

EXT2_HUMAN EXT2

82,238

100.00%

5

5

11

Nucleoredoxin

NXN_HUMAN NXN

48,376

100.00%

4

4

8

Protein MEMO1

MEMO1_HUMAN MEMO1

33,716

100.00%

2

2

2

97,134

100.00%

11

11

21

YEWDVAEAR 12.80% AADIDQEVKER ALTLIAGSPLK DLLDTVLPHLYNETK EGPAVVGQFIQDVK ITSEALLVTQQLVK LGTLSALDILIK LTLIDPETLLPR MLTGPVYSQSTALTHK SVILEAFSSPSEEVK TVSPALISR TYIQCIAAISR VIRPLDQPSSFDATPYIK 24.30% AIAYATHR ASAGSYISALR FQHGVIAAVDSR ISVSAASK KGPGLYYVDEHGTR VESTDVSDLLHQYR 7.52% ADPVLYKDDFPEK FASVFGTMPLK HGESVLVLDK LLVVWNNQNK LPADSPIPER 15.90% DYTNLPEAAPLLTILDMSAR EVIAGPLLR ISNIPSLIFLDATTGK LRGDAAAGPGPGAGAGAAAEPEPR

Glycogen phosphorylase, liver form PYGL_HUMAN PYGL

6.40% TGMFER YSYYDESQGEIYR 19.40% DFNVGDYIQAVLDR EYAQNIWNVEPSDLK EYYEALPELK FSQFLETEYK IDDVAALDKK INPSSMFDVQVK LITSVADVVNNDPMVGSK LVIDQIDNGFFSPK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

30.3 89.0 45.7 29.0 46.7 41.7 32.2 58.5 38.9 43.0 84.6 80.2 44.4 63.6 38.1 57.0 39.0 49.1 73.6 33.6 67.4 27.9 65.8 30.9 48.5 44.6 33.4 91.5 50.7 51.7 28.0 75.9 51.5 50.4 44.6 38.4 61.5 50.8 41.6 72.6 62.5 34.2 52.4 87.8 48.0 30.9 68.3 28.3 52.3 108.0 65.4

22.4 21.8 18.3 21.5 22.8 21.1 22.6 21.5 20.4 20.8 18.8 23.8 16.3 19.4 23.3 17.4 22.0 21.9 14.3 13.0 15.3 22.8 22.1 21.4 21.6 20.2 22.2 21.8 22.2 21.8 22.7 22.8 22.4 21.9 21.0 20.8 20.9 22.4 13.0 18.1 21.8 16.7 16.6 22.8 22.8 22.6 22.8 23.4 22.9 21.8 22.2

0 2 0 0 2 3 2 5 0 2 17 12 0 5 1 3 1 2 2 1 8 0 2 1 2 0 1 2 2 2 0 2 2 3 1 1 4 1 1 4 0 1 1 3 2 1 2 0 2 4 1

3 0 2 1 0 0 0 0 4 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 2 0 0 0 0 2 4 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 1 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,221.63 2,105.04 1,402.81 2,233.13 1,238.62 1,102.52 922.46 1,494.80 1,615.77 1,100.55 1,107.64 1,091.59 2,616.42 1,138.52 1,273.64 1,083.68 1,770.93 1,486.79 1,542.91 1,256.78 1,380.81 1,749.88 1,621.83 943.56 1,295.68 2,047.09 902.48 1,095.58 1,299.68 762.44 1,591.79 1,661.81 1,536.76 1,197.63 1,096.60 1,227.69 1,094.58 2,220.12 967.59 1,689.94 2,116.05 756.34 1,672.71 1,624.80 1,805.87 1,254.63 1,291.62 1,087.60 1,364.69 1,874.95 1,592.83

Table S1 page 78/159

40S ribosomal protein S12

RS12_HUMAN RPS12

14,497

99.50%

2

2

4

Moesin

MOES_HUMAN MSN

67,804

100.00%

49

60

875

TFAYTNHTVLPEALER VIFLENYR VLYPNDNFFEGK WLLLCNPGLAELIAEK YEYGIFNQK 18.90% LVEALCAEHQINLIK TALIHDGLAR 69.30% AKFYPEDVSEELIQDITQR ALELEQER ALTSELANAR ALTSELANARDESK AMLENEK AMLENEKK APDFVFYAPR AQMVQEDLEK AQQELEEQTR AQQELEEQTRR EALLQASR EDAVLEYLK EGILNDDIYCPPETAVLLASYAVQSK

EKEELMER ESEAVEWQQK ESPLLFK EVWFFGLQYQDTK FVIKPIDK FYPEDVSEELIQDITQR GFSTWLK GMLREDAVLEYLK IAQDLEMYGVNYFSIK IGFPWSEIR ILALCMGNHELYMR ISQLEMAR KAPDFVFYAPR KAQQELEEQTR KESPLLFK KPDTIEVQQMK KTANDMIHAENMR KTQEQLALEMAELTAR KVTAQDVR LFFLQVK LKQIEEQTK LNKDQWEER NISFNDKK QEAEEAKEALLQASR QIEEQTK QLFDQVVK QRIDEFESM RALELEQER RKPDTIEVQQMK SGYLAGDK TAMSTPHVAEPAENEQDEQDENGAEASADLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

44.5 50.2 55.6 48.8 35.8 35.8 30.0 30.5 53.2 81.8 83.4 36.3 42.0 80.6 64.3 66.8 38.5 68.0 41.3 36.2 33.2 53.0 30.4 72.8 41.1 96.5 37.8 45.5 102.0 68.8 40.7 64.0 47.6 79.5 42.6 64.0 61.2 113.0 39.5 42.2 31.0 58.2 31.2 80.9 39.4 58.8 54.3 46.7 51.6 45.3 95.4

22.1 21.6 21.8 19.2 22.1 18.4 20.5 21.4 23.3 22.9 23.0 22.5 23.6 21.7 21.6 22.4 22.6 23.7 23.2 21.6 21.6 20.5 20.7 22.1 17.2 22.3 21.2 21.3 22.4 23.4 21.7 23.4 22.3 22.5 17.6 23.1 20.1 21.5 22.5 18.9 22.3 22.2 22.7 22.7 23.5 21.4 18.1 22.7 22.3 23.4 14.3

0 5 3 2 1 0 0 0 22 34 6 3 1 84 41 6 0 10 7 0 2 8 1 8 6 37 4 2 60 121 2 18 25 9 17 5 5 18 1 11 3 8 2 4 1 19 10 9 12 9 0

2 0 0 0 0 2 2 5 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 17 0 7 0 0 0 0 2 10 0 0 6 18 0 0 0 1 0 4 0 0 0 0 33 0 21

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,861.94 1,053.57 1,442.70 1,840.00 1,161.56 1,750.95 1,066.60 2,281.14 987.51 1,045.56 1,504.76 850.40 962.50 1,182.59 1,206.57 1,231.59 1,387.69 887.50 1,079.56 2,866.42 1,079.50 1,233.58 833.48 1,660.80 959.59 2,082.00 838.45 1,552.80 1,906.93 1,104.58 1,752.82 963.49 1,310.69 1,359.69 961.57 1,316.69 1,546.71 1,831.96 916.52 894.55 1,116.63 1,217.59 965.51 1,672.85 875.45 976.55 1,170.51 1,143.61 1,488.78 810.40 3,328.42

Table S1 page 79/159

Splicing factor 3B subunit 3

SF3B3_HUMAN SF3B3

135,561

100.00%

7

7

35

7.97%

Nucleoporin Nup37

NUP37_HUMAN NUP37

36,689

99.50%

2

2

3

8.28%

Ig lambda chain C regions

LAC_HUMAN IGLC1

11,218

100.00%

3

3

9

41.90%

Protein Daple

DAPLE_HUMAN CCDC88C

228,201

99.50%

2

2

2

0.84%

Lamina-associated polypeptide 2, isoform alpha

LAP2A_HUMAN TMPO

75,476

100.00%

3

3

8

5.91%

Bile salt-activated lipase

CEL_HUMAN CEL

79,304

100.00%

4

4

16

7.84%

LIM and SH3 domain protein 1

LASP1_HUMAN LASP1

29,699

100.00%

4

5

18

20.30%

Protocadherin Fat 2

FAT2_HUMAN FAT2

479,291

100.00%

10

10

33

3.04%

Elongation factor 1-alpha 1

EF1A1_HUMAN EEF1A1

50,123

100.00%

12

13

134

27.90%

TANDMIHAENMR TQEQLALEMAELTAR VLEQHK VTAQDVR VTTMDAELEFAIQPNTTGK DYIVVGSDSGR FLAVGLVDNTVR IVILEYQPSK LGAVFNQVAFPLQYTPR LPPNTNDEVDEDPTGNK TPVEEVPAAIAPFQGR TVLDPVTGDLSDTR VDGIAWSPETR VGAVAGNDWLIWDITR AAPSVTLFPPSSEELQANK AGVETTTPSK YAASSYLSLTPEQWK KAELEER NADLSDASRK PEFLEDPSVLTK SSTPLPTISSSAENTR YGVNPGPIVGTTR AISQSGVALSPWVIQK LGLLGDSVDIFK VGCPVGDAAR VGPLGFLSTGDANLPGNYGLR GFSVVADTPELQR LKQQSELQSQVR MGPSGGEGMEPERR QSFTMVADTPENLR ATDSGQPPLSASVR AVAAQDPVIYSLVR DVIEINPVTGVVK GSVVENSEPGELVATLK IDPYLGDISLK IILTDENDNPPQFK TGVLTVTGPLDYESK VPQDTVPGVELLR VQAIDPDSR VSIEDVNDNPPK EHALLAYTLGVK EVSTYIK IGGIGTVPVGR KLEDGPK LPLQDVYK QLIVGVNK QTVAVGVIK STTTGHLIYK THINIVVIGHVDSGK VETGVLKPGMVVTFAPVNVTTEVK

YEEIVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

82.1 122.0 34.7 35.1 106.0 38.6 64.4 39.3 74.4 79.4 80.3 96.9 56.4 42.3 47.4 59.7 74.6 36.5 33.3 42.9 64.6 45.5 71.9 76.7 39.5 83.0 64.3 43.2 27.3 81.8 41.3 87.4 51.5 60.2 33.0 54.3 62.0 53.2 30.9 59.4 59.2 30.0 84.2 30.0 48.0 45.9 33.2 38.5 48.2 43.5 30.9

19.2 22.8 19.1 24.3 22.4 22.0 20.3 19.1 20.2 19.3 21.9 22.8 22.8 21.7 21.4 23.3 21.4 24.4 23.4 23.2 23.1 22.5 19.2 20.0 21.6 21.6 23.4 22.1 16.3 23.2 22.3 20.3 16.9 21.8 22.0 23.1 22.3 19.1 20.6 23.0 20.5 21.6 16.1 19.8 21.1 17.1 19.4 21.3 20.0 16.0 20.6

21 29 2 6 27 1 3 1 4 6 11 9 2 1 1 4 4 1 1 2 4 2 4 6 2 4 4 2 0 6 2 6 2 2 1 2 4 8 1 5 7 1 37 1 11 2 1 5 0 0 1

3 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 12 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,402.62 1,703.86 753.43 788.43 2,082.01 1,167.56 1,303.74 1,189.68 1,921.03 1,854.84 1,681.89 1,488.75 1,230.61 1,785.93 1,986.02 990.51 1,743.86 874.46 1,076.53 1,374.72 1,647.82 1,330.71 1,683.94 1,276.72 1,001.48 2,118.10 1,418.73 1,443.79 1,521.64 1,608.77 1,385.70 1,501.84 1,382.79 1,728.90 1,233.67 1,643.83 1,579.82 1,422.80 1,000.51 1,326.65 1,314.74 839.45 1,025.61 786.44 975.55 870.54 914.57 1,120.60 1,588.88 2,531.38 780.41

Table S1 page 80/159

PGTB2_HUMAN RABGGTB

36,907

99.50%

2

2

2

PSMD6_HUMAN PSMD6

45,515

100.00%

6

6

10

Protein disulfide-isomerase A4

PDIA4_HUMAN PDIA4

72,916

100.00%

28

32

291

Macrophage-capping protein

CAPG_HUMAN CAPG

38,500

100.00%

8

8

31

Laminin subunit alpha-5

LAMA5_HUMAN LAMA5

399,769

100.00%

57

61

662

Geranylgeranyl transferase type-2 subunit beta 26S proteasome non-ATPase regulatory subunit 6

YYVTIIDAPGHR 6.65% HADYIASYGSK SDAPDTLLLEK 15.20% ANEDELK IDKVNEIVETNRPDSK IGLFYMDNDLITR PLENLEEEGLPK RLDEELEDAEK VNEIVETNRPDSK 42.20% DKDPPIPVAK DLGLSESGEDVNAAILDESGK DLGLSESGEDVNAAILDESGKK EFVTAFK EKYGIVDYMIEQSGPPSK EVSQPDWTPPPEVTLVLTK FAMEPEEFDSDTLR FDVSGYPTIK FEGGDRDLEHLSK FIEEHATK GESDPAYQQYQDAANNLR GQAVDYEGSR IDATSASVLASR KGQAVDYEGSR MDATANDVPSDR RFDVSGYPTIK RSPPIPLAK SHMMDVQGSTQDSAIK SHMMDVQGSTQDSAIKDFVLK TFDSIVMDPK TQEEIVAK VDATAETDLAK VDATAETDLAKR VEGFPTIYFAPSGDK VEGFPTIYFAPSGDKK VSQGQLVVMQPEK YALPLVGHR YGIVDYMIEQSGPPSK 32.80% AQVEIVTDGEEPAEMIQVLGPKPALK DLALAIR EGNPEEDLTADK EVQGNESDLFMSYFPR MQYAPNTQVEILPQGR QAALQVAEGFISR VSDATGQMNLTK YQEGGVESAFHK 18.70% AGALLPAIHEQLR AHPASNAIDGTER AIEASNAYSR AIQVFLLGGSR ASPDGLCQVSLQQGR AVAAEAQDTATR

95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

64.3 30.2 38.9 30.4 20.4 70.7 56.0 52.3 27.6 41.0 114.0 123.0 33.3 42.1 57.7 70.8 67.2 37.6 51.4 113.0 59.1 112.0 83.8 83.3 44.3 41.0 41.5 38.7 60.4 40.7 67.7 72.4 56.8 57.5 80.7 51.0 98.9 38.5 48.8 64.1 70.8 76.6 86.5 66.4 60.2 45.1 43.7 72.8 76.4 94.6 119.0

22.8 20.9 22.3 20.5 21.0 22.3 22.0 22.7 22.9 20.0 22.2 21.5 21.5 21.8 20.3 17.2 22.1 21.7 22.7 19.2 20.8 22.5 22.9 17.9 21.7 9.0 20.8 21.5 22.1 23.6 22.9 24.2 22.1 22.3 22.4 18.1 22.3 19.6 20.0 19.2 20.9 22.6 22.5 22.4 21.6 19.2 22.6 22.0 18.1 22.0 23.6

16 1 1 2 0 2 2 2 0 4 2 2 1 0 16 18 27 2 4 10 6 24 5 46 4 1 2 0 18 5 14 7 5 2 24 4 13 0 4 2 5 4 6 4 3 6 4 31 18 5 63

26 0 0 0 0 0 0 0 1 0 0 7 0 3 0 0 0 0 0 0 0 0 7 0 1 0 0 5 0 0 0 2 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,404.73 1,211.57 1,201.63 818.39 1,856.97 1,586.79 1,367.71 1,346.64 1,500.77 1,079.61 2,119.00 2,247.10 841.45 2,041.00 2,136.12 1,702.73 1,126.58 1,502.72 974.49 2,039.91 1,081.49 1,190.64 1,209.59 1,307.55 1,282.68 978.61 1,766.77 2,369.11 1,152.56 917.49 1,133.57 1,289.67 1,627.80 1,755.90 1,458.76 1,025.59 1,783.86 2,778.46 771.47 1,317.58 1,918.86 1,844.93 1,389.75 1,280.62 1,351.63 1,388.80 1,338.64 1,081.53 1,160.68 1,615.79 1,203.60

Table S1 page 81/159

AVPLQPPPPLTSASK CDQCSLGTFSLDAANPK CNCPPGLSGER DLADLAAYTALK DLGAPQAAAEAELAAAQR DQASQLLAGTEATLGHAK DTLASVFR EAQELNSR ECAPGYWGLPEQGCR ENVQGPK FANSPRPDLWVLER FPKPPQPIILR FYLQGPEPEPGQGTEDR GALDQLCGAGGLCR GAMSVSGR GDSCQECAPGFYR GFGEPFVLNPGTWALR GPPPELQPQPEGPPR GQDLGQAVLDAGHSVSTLEK GQLQLVEGNFR GQYCDICTAANSNK GYAQMAPVQPR HETAQQLEVLEQQSTSLGQDAR IAASATCGEEAPAR ILLVTDGAR ISFDSQISTTK LAASLDGAR LAQHEAGLMDLR LEEALQR LELEEAATPEGHAVR LGLVWAALQGAR LLWEMR LTAEQAR LVGGPVAGGDPNQTIR MQTFSPAGSK QATGDYMGVSLR QEVGVAVHTPQR QMIQETK STGDPWLTDGSYLDGTGFAR TLAEVER TLLAAIR TPLLQR TYQPWQFFASSK VQEQLSSLWEENQALATQTR VQSQLQAMQENVER VSLQLLR VSSYGGTLR WQGQYEGLR WWQSPPLSR YALVVEYANEDAR YELHSETQR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0%

42.8 70.9 35.7 80.4 115.0 106.0 49.4 53.6 56.2 33.3 30.8 33.8 92.6 90.9 52.3 34.7 40.1 81.6 104.0 81.8 98.4 61.1 36.8 90.3 41.4 66.4 58.0 34.7 30.2 83.6 78.4 38.7 44.6 78.7 43.4 51.8 32.8 36.2 132.0 39.5 38.8 44.8 57.2 98.7 110.0 45.7 46.4 38.7 30.3 36.7 34.4

18.0 19.5 17.0 21.8 22.2 21.4 21.9 21.8 18.6 20.8 21.2 10.8 20.8 20.7 22.3 10.4 22.3 22.1 22.1 23.5 16.4 22.9 21.4 21.6 20.0 22.2 24.0 22.2 22.9 22.4 17.8 24.3 24.3 21.4 22.3 22.2 22.4 23.8 20.9 24.1 21.8 19.0 22.5 21.6 22.7 21.8 21.1 22.6 21.9 22.3 21.9

2 2 2 17 24 12 22 9 2 2 0 0 13 11 2 2 1 29 11 22 2 10 0 4 3 13 13 0 1 14 52 2 6 23 2 8 3 3 10 4 10 13 5 7 37 14 11 4 1 1 0

0 0 0 0 0 2 0 0 0 0 4 4 0 0 0 0 0 0 31 0 0 0 2 0 0 0 0 4 0 25 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,502.86 1,883.83 1,246.53 1,264.68 1,752.89 1,810.93 908.48 946.46 1,779.76 771.40 1,699.89 1,305.81 1,919.88 1,447.68 764.37 1,546.61 1,760.91 1,595.82 2,025.03 1,260.67 1,601.67 1,217.61 2,468.20 1,403.66 957.57 1,226.63 873.48 1,353.70 858.47 1,621.82 1,254.73 847.45 788.43 1,550.83 1,053.50 1,297.62 1,320.70 877.45 2,115.96 817.44 757.49 727.45 1,489.71 2,331.16 1,659.81 828.53 939.49 1,136.55 1,156.59 1,512.73 1,162.55

Table S1 page 82/159

Metalloproteinase inhibitor 1

TIMP1_HUMAN TIMP1

23,153

100.00%

5

7

431

D-tyrosyl-tRNA(Tyr) deacylase 1

DTD1_HUMAN DTD1

23,406

100.00%

3

3

6

15,146

100.00%

3

3

10

Fatty acid-binding protein, epidermal FABP5_HUMAN FABP5

Lysyl-tRNA synthetase

SYK_HUMAN KARS

68,032

100.00%

8

8

13

Pre-mRNA-splicing factor SPF27

SPF27_HUMAN BCAS2

26,113

99.50%

2

2

6

Ezrin

EZRI_HUMAN EZR

69,397

100.00%

29

36

330

32.40% EPGLCTWQSLR FVYTPAMESVCGYFHR GFQALGDAADIR LQSGTHCLWTDQLLQGSEK SEEFLIAGK 14.80% ASVTVGGEQISAIGR SASSGAEGDVSSER SASSGAEGDVSSEREP 23.70% ELGVGIALR FEETTADGR LVVECVMNNVTCTR 11.70% INMVEELEK LIFYDLR LPETNLFETEETR LPETNLFETEETRK LQVMANSR MLVVGGIDR VAMFLTDSNNIK YLDLILNDFVR 10.70% TIVQLENEIYQIK YELPAPSSGQK 53.90% AKEAQDDLVK AKEELER ALQLEEER APDFVFYAPR AQEEAERLEADR DNAMLEYLK EAQDDLVK EKEELMLR ELSEQIQR ENPLQFK FVIKPIDK FYPEDVAEELIQDITQK GFPTWLK GMLKDNAMLEYLK IALLEEAR IAQDLEMYGINYFEIK IGFPWSEIR ILQLCMGNHELYMR IQVWHAEHR ITEAEKNER KAPDFVFYAPR KENPLQFK KPDTIEVQQMK KVSAQEVR LFFLQVK NISFNDKK QAVDQIK QLFDQVVK QLLTLSSELSQAR QQLETEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

38.2 97.1 106.0 133.0 65.6 36.6 36.7 53.7 37.2 52.5 71.1 32.4 38.7 72.5 44.3 35.8 31.4 40.9 45.6 56.3 29.5 57.1 40.5 45.8 80.6 42.2 47.8 42.5 32.8 49.8 35.5 41.1 82.5 30.7 65.8 56.8 79.9 68.8 45.8 33.2 51.7 47.6 31.1 64.0 51.1 42.2 31.2 48.6 58.8 113.0 40.8

22.8 20.1 23.5 21.9 21.7 21.9 18.8 17.9 17.1 19.8 22.3 24.2 19.0 22.6 23.1 23.3 23.7 23.3 20.8 20.3 22.7 24.0 24.4 21.6 21.7 21.3 22.9 22.2 23.9 22.9 24.5 17.2 22.0 23.9 22.3 18.6 22.0 23.4 21.6 23.1 23.5 22.3 21.9 23.1 22.5 18.9 22.7 21.7 21.4 21.4 23.5

6 18 259 9 100 1 1 4 2 4 4 1 1 2 0 1 2 2 2 2 0 5 4 17 84 12 15 1 1 10 1 6 5 1 5 34 25 121 2 1 3 25 1 5 4 11 2 7 19 45 6

0 1 0 38 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 4 0 0 0 0 6 0 0 0 0 0 0 5 0 4 0 0 0 1 0 2 2 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,346.65 1,963.88 1,233.62 2,201.07 993.53 1,444.78 1,338.58 1,564.67 927.56 1,025.45 1,694.80 1,104.56 939.53 1,578.77 1,706.86 934.48 975.53 1,368.68 1,380.75 1,590.87 1,176.59 1,116.59 874.46 987.51 1,182.59 1,416.67 1,096.54 917.46 1,063.55 1,002.52 875.46 959.59 2,038.00 848.47 1,525.78 914.53 1,962.95 1,104.58 1,809.85 1,175.61 1,089.55 1,310.69 1,003.56 1,316.69 916.52 894.55 965.51 801.45 976.55 1,445.80 875.45

Table S1 page 83/159

Thioredoxin-dependent peroxide reductase, mitochondrial

PRDX3_HUMAN PRDX3

27,675

100.00%

4

4

22

Latent-transforming growth factor beta-binding protein 3

LTBP3_HUMAN LTBP3

139,337

100.00%

5

6

18

Annexin A1

QQLETEKK QRIDEFEAL RKPDTIEVQQMK SGYLSSER SQEQLAAELAEYTAK THNDIIHNENMR VSAQEVR VSAQEVRK VTTMDAELEFAIQPNTTGK 18.40% DYGVLLEGSGLALR GLFIIDPNGVIK GTAVVNGEFK HLSVNDLPVGR 6.52% CTCAQGYAPAPDGR FCQVPAGGAGGGTGGSGPGLSR

ANXA1_HUMAN ANXA1

38,698

100.00%

18

25

353

GAGGGGALAR GYTQDNNIVNYGIPAHR TGALSTGALPPLAPEGDSVASK 58.10% AAYLQETGKPLDETLK AAYLQETGKPLDETLKK ALYEAGER CATSKPAFFAEK DITSDTSGDFR GDRSEDFGVNEDLADSDAR GGPGSAVSPYPTFNPSSDVAALHK

Bifunctional purine biosynthesis protein PURH

PUR9_HUMAN ATIC

64,599

100.00%

6

6

10

16.40%

Reticulocalbin-1

RCN1_HUMAN RCN1

38,873

100.00%

4

4

11

12.10%

Caveolin-1

CAV1_HUMAN CAV1

20,454

100.00%

2

2

2

19.70%

Nucleoside diphosphate kinase B

NDKB_HUMAN NME2

17,280

100.00%

11

14

74

73.70%

GLGTDEDTLIEILASR GTDVNVFNTILTTR GVDEATIIDILTK GVDEATIIDILTKR KGTDVNVFNTILTTR MYGISLCQAILDETKGDYEK NALLSLAK QAWFIENEEQEYVQTVK SEDFGVNEDLADSDAR SEIDMNDIK TPAQFDADELR AEISNAIDQYVTGTIGEDEDLIK ALFEEVPELLTEAEKK APGQLALFSVSDK DVSELTGFPEMLGGR EVSDGIIAPGYEEEALTILSK SLFSNVVTK AADLNGDLTATR IDNDGDGFVTTEELK TFDQLTPDESK TFDQLTPDESKER IDFEDVIAEPEGTHSFDGIWK YVDSEGHLYTVPIR ASEEHLK DRPFFPGLVK EISLWFKPEELVDYK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

33.7 43.5 51.6 61.3 125.0 55.5 40.3 36.8 106.0 103.0 58.5 35.2 55.4 59.6 106.0 55.8 32.0 65.9 65.7 68.1 55.8 48.4 82.2 95.4 67.4 122.0 102.0 98.1 52.0 114.0 32.8 40.7 98.3 122.0 48.6 88.1 80.7 40.5 72.3 36.8 90.1 31.0 81.2 114.0 34.6 57.9 62.7 30.5 48.6 38.5 44.1

22.9 23.6 22.3 20.5 22.5 21.5 24.7 22.5 22.4 22.0 18.3 22.6 21.9 15.2 21.6 19.0 22.8 21.2 21.4 18.2 22.5 21.0 19.3 17.8 22.1 21.8 21.8 20.9 19.1 20.3 20.6 20.9 22.2 18.0 21.3 22.1 21.9 20.9 22.3 21.8 20.9 19.5 23.0 22.6 22.1 22.7 21.4 23.5 20.3 20.6 21.1

1 5 12 17 68 3 4 2 27 10 8 1 3 2 1 2 0 9 2 4 8 4 21 2 3 54 40 69 3 9 0 3 25 9 11 30 1 2 2 2 2 1 2 4 1 4 1 0 5 3 3

0 0 33 0 5 2 0 0 0 0 0 0 0 0 1 0 3 0 1 9 0 2 0 9 29 2 0 0 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2

1,003.54 1,120.56 1,488.78 898.43 1,651.82 1,509.69 788.43 916.52 2,082.01 1,462.79 1,285.75 1,021.53 1,206.66 1,523.64 1,946.91 786.42 1,931.94 2,039.07 1,776.94 1,905.03 908.45 1,356.66 1,213.53 2,067.89 2,356.16 1,702.89 1,550.82 1,387.77 1,543.87 1,678.91 2,350.10 829.51 2,141.02 1,739.74 1,064.49 1,262.60 2,494.22 1,845.99 1,332.72 1,623.77 2,234.14 994.56 1,217.61 1,652.77 1,280.60 1,565.75 2,405.13 1,648.83 813.41 1,175.66 1,895.98

Table S1 page 84/159

28 kDa heat- and acid-stable phosphoprotein

HAP28_HUMAN PDAP1

20,613

100.00%

4

4

10

22.10%

Septin-11

SEP11_HUMAN SEPT11

49,381

100.00%

4

5

7

14.70%

Protein S100-A11

S10AB_HUMAN S100A11

11,723

100.00%

7

8

100

56.20%

Carbonyl reductase [NADPH] 1

CBR1_HUMAN CBR1

30,357

100.00%

10

11

70

53.80%

GDFCIQVGR GLVGEIIK GLVGEIIKR NIIHGSDSVK SAEKEISLWFKPEELVDYK TFIAIKPDGVQR VMLGETNPADSKPGTIR YMNSGPVVAMVWEGLNVVK GVEGLIDIENPNR KVTQLDLDGPK QYTSPEEIDAQLQAEK VTQLDLDGPK AAAQLLQSQAQQSGAQQTK FESDPATHNEPGVR STLMDTLFNTK SYELQESNVR VNIIPIIAK CIESLIAVFQK DGYNYTLSK DPGVLDR ISSPTETER NQKDPGVLDR TEFLSFMNTELAAFTK YAGKDGYNYTLSK DVCTELLPLIKPQGR EGWPSSAYGVTK EYGGLDVLVNNAGIAFK FHQLDIDDLQSIR GIGLAIVR GQAAVQQLQAEGLSPR ILLNACCPGWVR SETITEEELVGLMNK SPEEGAETPVYLALLPPDAEGPHGQFVSEK

Lysosomal Pro-X carboxypeptidase

PCP_HUMAN

PRCP

55,783

99.50%

2

2

7

Ras-related protein R-Ras

RRAS_HUMAN RRAS

23,463

100.00%

3

3

7

Heat shock protein HSP 90-beta

HS90B_HUMAN HSP90AB1

83,249

100.00%

38

49

810

VVNVSSIMSVR 5.24% NALDPMSVLLAR YYGESLPFGDNSFK 16.10% ADLESQR LDILDTAGQEEFGAMR LNVDEAFEQLVR 46.00% ADHGEPIGR ADLINNLGTIAK ALLFIPR APFDLFENK DNSTMGYMMAK EDQTEYLEER EGLELPEDEEEK EGLELPEDEEEKK EKYIDQEELNK ELISNASDALDK ELISNASDALDKIR ELKIDIIPNPQER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

51.1 36.3 52.3 40.6 31.4 34.9 88.7 118.0 72.9 49.5 98.7 41.8 135.0 65.3 35.8 44.9 39.9 70.9 54.8 45.5 34.5 39.7 104.0 51.9 62.0 58.1 74.9 40.5 48.8 96.8 58.2 106.0 84.2 87.9 58.2 52.9 38.6 79.5 114.0 35.9 74.8 51.5 37.6 55.5 49.1 58.8 43.1 55.1 92.5 108.0 37.3

22.8 16.7 16.7 21.7 20.7 19.8 22.3 22.3 22.6 21.3 22.0 21.8 21.5 21.7 22.0 21.0 9.5 21.2 20.7 20.5 22.4 21.6 22.4 22.5 19.1 21.4 21.3 21.8 14.8 21.8 22.9 22.0 20.3 22.4 21.1 20.8 23.3 22.1 23.0 22.0 20.9 17.1 22.7 11.8 18.8 20.1 20.8 23.3 23.1 21.4 18.5

4 2 5 1 0 2 4 19 2 2 4 2 2 1 1 1 6 6 6 2 2 0 79 2 1 5 6 0 5 8 4 9 0 8 5 2 1 3 3 3 86 11 4 6 12 3 2 4 15 10 2

0 0 0 0 2 0 8 12 0 0 0 0 2 0 0 0 0 0 0 0 0 2 1 0 0 0 0 10 0 4 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0

0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,051.50 828.52 984.62 1,069.56 2,311.19 1,344.76 1,785.92 2,125.05 1,425.73 1,213.68 1,849.88 1,085.58 1,957.01 1,555.71 1,286.63 1,224.59 980.65 1,307.70 1,060.50 771.40 1,019.50 1,141.60 1,849.90 1,479.71 1,738.95 1,281.61 1,779.93 1,599.81 798.52 1,652.87 1,458.74 1,692.84 3,164.54 1,206.65 1,299.71 1,623.73 818.40 1,765.84 1,432.74 951.47 1,242.71 829.53 1,080.54 1,280.50 1,311.57 1,416.64 1,544.73 1,408.70 1,275.64 1,544.83 1,564.87

Table S1 page 85/159

Polypeptide Nacetylgalactosaminyltransferase 12

GLT12_HUMAN GALNT12

66,921

100.00%

3

3

4

60 kDa heat shock protein, mitochondrial

CH60_HUMAN HSPD1

61,038

100.00%

11

14

57

EMLQQSK EQVANSAFVER GVVDSEDLPLNISR HFSVEGQLEFR HLEINPDHPIVETLR HNDDEQYAWESSAGGSFTVR HSQFIGYPITLYLEK IDIIPNPQER IEDVGSDEEDDSGK IEDVGSDEEDDSGKDK IRYESLTDPSK KHLEINPDHPIVETLR LGIHEDSTNR LSELLR NPDDITQEEYGEFYK RAPFDLFENK SIYYITGESK SLTNDWEDHLAVK SLVSVTK TLTLVDTGIGMTK VILHLK VILHLKEDQTEYLEER YESLTDPSK YESLTDPSKLDSGK YHTSQSGDEMTSLSEYVSR YIDQEELNK 5.16% ESSDSFVPLLR LANELSGLPK LQLQGEELR 25.10% ALMLQGVDLLADAVAVTMGPK APGFGDNRK GYISPYFINTSK ISSIQSIVPALEIANAHR KISSIQSIVPALEIANAHR LSDGVAVLK LVQDVANNTNEEAGDGTTTATVLAR

High mobility group protein B1

HMGB1_HUMAN HMGB1

24,877

100.00%

9

16

121

TLNDELEIIEGMK TVIIEQSWGSPK VGEVIVTKDDAMLLK VTDALNATR 40.50% FKDPNAPK GEHPGLSIGDVAK GEHPGLSIGDVAKK HPDASVNFSEFSK IKGEHPGLSIGDVAK KHPDASVNFSEFSK LGEMWNNTAADDKQPYEK MSSYAFFVQTCR TYIPPK TYIPPKGETK YEKDIAAYR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

50.8 76.7 113.0 64.6 69.1 133.0 73.6 57.1 62.6 32.8 47.5 30.3 53.3 44.8 91.9 49.7 54.9 83.6 43.2 109.0 35.5 69.3 43.0 67.9 75.7 60.6 33.7 35.1 45.2 73.6 34.4 68.3 60.0 26.8 48.1 139.0 72.3 69.6 31.0 58.2 42.0 45.4 47.6 52.8 62.7 40.2 76.8 104.0 39.9 35.2 50.4

23.4 23.5 22.4 23.7 21.0 17.3 21.8 21.4 15.1 17.3 22.3 18.4 22.5 23.2 17.8 22.6 23.7 21.8 18.8 22.1 7.8 22.0 23.0 22.6 17.9 23.1 23.1 17.5 21.6 20.9 24.4 23.4 17.7 14.6 20.6 21.8 23.3 22.1 20.2 24.0 23.5 22.8 21.1 21.1 19.7 23.1 20.8 19.7 22.7 21.6 22.0

6 18 54 7 2 7 5 13 1 0 2 0 9 17 21 6 6 97 2 57 7 7 9 14 3 21 1 1 2 2 1 4 2 0 1 4 8 4 0 8 9 2 0 3 14 2 7 19 1 2 5

0 0 0 4 8 54 9 0 0 2 0 0 13 0 0 0 0 7 0 0 0 102 0 3 45 0 0 0 0 14 0 0 4 1 0 3 0 0 1 0 0 0 1 2 30 15 15 0 0 2 2

0 0 0 0 1 0 0 0 0 0 0 11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 15 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

879.42 1,249.62 1,513.79 1,348.67 1,782.95 2,255.96 1,808.96 1,194.65 1,494.61 1,737.73 1,308.68 1,911.05 1,141.56 730.45 1,847.80 1,236.64 1,160.58 1,527.74 733.45 1,365.73 722.49 2,015.05 1,039.49 1,539.75 2,192.94 1,151.56 1,249.64 1,041.59 1,085.60 2,145.13 961.49 1,389.71 1,919.07 2,047.17 901.54 2,560.25 1,504.76 1,344.72 1,646.90 960.51 916.49 1,279.66 1,407.76 1,464.68 1,520.84 1,592.77 2,109.96 1,512.66 718.41 1,133.62 1,128.57

Table S1 page 86/159

Prostaglandin reductase 1

PTGR1_HUMAN PTGR1

35,853

100.00%

6

7

14

Ras GTPase-activating-like protein IQGAP1

IQGA1_HUMAN IQGAP1

189,241

100.00%

30

32

145

26.40% EYIIEGFENMPAAFMGMLK HFVGYPTNSDFELK LKEGDTMMGQQVAK TGPLPPGPPPEIVIYQELR TVESLEETLKK VVGAVGSDEK 24.60% ALESGDVNTVWK ALQSPALGLR ATFYGEQVDYYK EEIQSSISGVTAAYNR EQLWLANEGLITR FLSAIVSSVDK FQPGETLTEILETPATSEQEAEHQR

GLQQQNSDWYLK IFYPETTDIYDR IFYPETTDIYDRK IIGNLLYYR ILAIGLINEALDEGDAQK ITLQDVVSHSK LAAVALINAAIQK LEGVLAEVAQHYQDTLIR LGLAPQIQDLYGK LGNFFSPK LPYDVTPEQALAHEEVK LQQTYAALNSK LTAEEMDER NPNAMLVNLEEPLASTYQDILYQAK QSGQTDPLQKEELQSGVDAANSAAQQYQR

Glutathione S-transferase P

GSTP1_HUMAN GSTP1

23,339

100.00%

15

19

715

SNQQLENDLNLMDIK SWVNQMESQTGEASK TLINAEDPPMVVVR TLQALQIPAAK VDFTEEEINNMK VDQIQEIVTGNPTVIK YGIQMPAFSK YQELINDIAR 70.00% AFLASPEYVNLPINGNGK AFLASPEYVNLPINGNGKQ ALPGQLKPFETLLSQNQGGK ASCLYGQLPK DQQEAALVDMVNDGVEDLR EEVVTVETWQEGSLK FQDGDLTLYQSNTILR MLLADQGQSWK MLLADQGQSWKEEVVTVETWQEGSLK

MPPYTVVYFPVR PPYTVVYFPVR TLGLYGK TLGLYGKDQQEAALVDMVNDGVEDLR

YISLIYTNYEAGK YISLIYTNYEAGKDDYVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

58.6 41.9 39.0 59.2 40.7 40.1 75.9 54.2 68.1 100.0 94.1 42.3 51.2 31.2 50.3 27.3 61.9 118.0 38.2 76.0 78.1 47.5 44.0 54.1 51.7 70.4 44.6 97.1 87.4 109.0 61.0 72.2 59.5 78.1 47.8 36.5 90.3 86.5 84.9 57.3 129.0 102.0 141.0 67.4 50.8 76.9 73.2 41.0 75.3 55.5 121.0

21.0 22.0 22.2 18.1 21.7 23.7 23.1 16.1 20.0 22.1 21.2 20.8 20.3 22.8 22.4 22.9 20.0 19.9 21.4 13.2 19.6 20.3 21.8 21.5 22.4 18.8 20.6 20.6 22.6 18.9 20.7 15.3 20.0 18.7 21.8 23.7 21.6 21.6 18.5 22.5 21.8 23.2 21.8 23.1 21.6 22.1 21.2 21.1 21.3 22.7 22.1

2 2 2 4 0 1 6 3 4 3 6 1 0 1 2 0 4 16 0 4 4 4 5 0 4 5 0 0 2 2 8 6 6 4 4 3 4 3 29 10 78 81 136 14 0 4 119 27 0 4 84

0 0 2 0 1 0 0 0 0 0 0 0 9 0 0 1 0 9 2 0 3 0 0 6 0 0 4 4 0 0 0 0 0 0 0 0 4 0 73 0 9 0 0 0 4 0 0 0 22 0 10

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2

2,239.01 1,653.79 1,567.75 2,073.14 1,276.70 960.50 1,318.66 1,025.61 1,483.67 1,724.85 1,542.83 1,165.65 2,841.35 1,479.72 1,532.73 1,660.82 1,124.65 1,883.01 1,226.67 1,295.81 2,055.09 1,415.79 909.48 1,938.98 1,236.66 1,109.48 2,851.42 3,147.49 1,790.86 1,697.74 1,553.84 1,153.69 1,468.66 1,753.97 1,141.57 1,234.64 1,903.99 2,032.05 2,126.16 1,136.58 2,116.98 1,733.86 1,883.95 1,276.64 3,007.47 1,484.76 1,337.73 751.44 2,849.40 1,534.78 2,155.06

Table S1 page 87/159

Fibronectin

FINC_HUMAN FN1

262,581

100.00%

5

5

18

14-3-3 protein zeta/delta

1433Z_HUMAN YWHAZ

27,728

100.00%

21

27

754

3.31% ITYGETGGNSPVQEFTVPGSK LGVRPSQGGEAPR NLQPASEYTVSLVAIK SYTITGLQPGTDYK VPGTSTSATLTGLTR 73.90% DICNDVLSLLEK DNLTLWTSDTQGDEAEAGEGGEN

Agrin

AGRIN_HUMAN AGRN

214,820

100.00%

70

86

1629

DSTLIMQLLR EKIETELR EMQPTHPIR FLIPNASQAESK GIVDQSQQAYQEAFEISK GIVDQSQQAYQEAFEISKK KEMQPTHPIR KGIVDQSQQAYQEAFEISK LAEQAER LAEQAERYDDMAACMK MKGDYYR NELVQK NLLSVAYK NLLSVAYKNVVGAR SVTEQGAELSNEER TAFDEAIAELDTLSEESYK YDDMAACMK YLAEVAAGDDK YLAEVAAGDDKK 41.60% AAAVSSGFDGAIQLVSLGGR AIVDVHFDPTTAFR ALEPQGLLLYNGNAR ALGPAGCEADASAPATCAEMR ALQSNHFELSLR ASCYNSALGCCSDGK AYGTGFVGCLR AYHTLR CEFGAR CEHPPPGPVCGSDGVTYGSACELR

DDCEQMTGLCSCKPGVAGPK DFLALALLDGR DQCPEPCR EAACLQQTQIEEAR EPLYVGGAPDFSK EPVTLGAWTR ESLLDGGNK FDGPCDPCQGALPDPSR FDTGSGPAVLTSAVPVEPGQWHR

FGALCEAETGR FHCQCPPGR FNAVCLSR GAPEGTVCGSDGADYPGECQLLR

GDFVSLALR GIVTDGR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

58.0 44.8 49.4 45.4 80.8 82.6 129.0 79.3 47.8 67.1 62.7 134.0 74.9 43.9 115.0 59.4 50.3 42.7 31.1 51.4 79.1 112.0 114.0 59.2 47.0 79.5 106.0 56.0 36.1 119.0 66.7 109.0 64.2 37.0 35.5 38.6 41.4 49.9 35.0 105.0 63.3 30.0 38.5 50.9 93.8 87.4 29.5 72.7 123.0 62.2 33.1

21.7 21.1 20.4 21.8 21.6 23.7 13.8 21.3 22.3 22.4 23.7 21.8 22.5 22.5 22.5 21.6 16.1 19.2 22.9 19.1 17.7 20.7 20.6 10.0 22.5 22.7 21.1 22.2 21.0 17.2 22.1 10.4 21.2 24.2 18.8 16.2 14.5 21.5 11.5 21.8 22.7 23.4 23.5 16.6 20.8 20.8 18.0 23.2 16.3 21.4 24.0

2 0 1 2 5 60 14 113 5 13 21 169 6 0 3 36 0 6 2 49 4 64 34 21 8 53 109 5 0 7 6 4 16 6 1 0 0 3 4 11 16 1 1 2 5 35 0 32 10 24 2

0 8 0 0 0 0 0 0 0 0 0 8 7 11 4 0 2 0 0 0 2 0 10 0 0 29 0 1 2 4 6 0 0 0 0 1 4 0 0 0 0 0 0 0 101 0 2 0 3 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,168.05 1,323.71 1,732.95 1,543.76 1,461.79 1,418.72 2,409.00 1,189.66 1,017.56 1,108.56 1,304.69 2,040.99 2,169.08 1,252.65 2,169.08 816.42 1,933.81 932.43 730.41 907.53 1,503.86 1,548.71 2,131.99 1,104.42 1,151.56 1,279.65 1,875.99 1,588.81 1,628.88 2,105.91 1,414.74 1,649.64 1,200.58 760.41 739.32 2,602.11 2,225.93 1,203.67 1,061.41 1,646.78 1,379.68 1,129.60 932.47 1,888.80 2,408.20 1,210.55 1,158.49 966.48 2,409.05 977.54 717.39

Table S1 page 88/159

GKDFLALALLDGR GLYVAAQGACR GMLCGFGAVCEPNAEGPGR GPSGLLLYNGQK GSGVGECGDHPCLPNPCHGGAPCQNLEAGR

HQGPCDQAPSPCLGVQCAFGATCAVK

IFFVNPAPPYLWPAHK KFDGPCDPCQGALPDPSR KSPCPSVVAPVCGSDASTYSNECELQR

LALEFR LELGIGPGAATR LLDVNNQR LRDLGPGK MALEVVFLAR QAPVCGDDGVTYENDCVMGR QENVFK QIQVSR QLLTPEHVLR QVDVTSFAGHPCTR RLEFR SADGLTASCLCPATCR SAGDVDTLAFDGR SELFGETAR SFLAFPTLR SGCTPCSCDPQGAVR SIESTLDDLFR SPCPSVVAPVCGSDASTYSNECELQR

SPCQPNPCHGAAPCR SREPVTLGAWTR STVPVNTNR TDGKGDFVSLALR TEATQGLVLWSGK TFVEYLNAVTESEK TFVGAGLR TPSLDAEGSNCPATK TYDSDCWR VCGSDGVTYGNECQLK VGPTCADEK VGPTCADEKSPCQPNPCHGAAPCR

VLGAPVPAFEGR VLGESPVPHTVLNLK VLGESPVPHTVLNLKEPLYVGGAPDFSK

Ribosome-binding protein 1

RRBP1_HUMAN RRBP1

152,453

100.00%

4

4

11

Kinesin-1 heavy chain

KINH_HUMAN KIF5B

109,668

100.00%

4

4

8

VLPEGGAQCECPLGR VTCDGAYRPVCAQDGR VVISGFGDPLICDNQVSTGDTR 4.33% DALNQATSQVESK DAQDVQASQAEADQQQTR GNTPATGTTQGK VEPAVSSVVNSIQVLTSK 5.30% ISFLENNLEQLTK LITDLQDQNQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

103.0 69.6 94.2 57.2 35.9 55.0 29.5 34.3 57.7 40.6 79.9 57.4 50.7 62.6 119.0 33.2 31.6 43.5 69.8 33.2 89.9 115.0 57.2 58.0 82.9 70.9 67.8 63.2 51.4 53.1 76.5 103.0 124.0 55.5 97.3 49.4 106.0 51.0 70.6 69.0 71.0 60.9 81.1 37.7 108.0 72.8 139.0 38.5 61.8 54.2 45.7

19.9 23.5 17.4 22.0 14.5 18.8 20.1 19.3 18.6 21.6 20.2 20.9 18.1 20.4 14.8 24.0 24.0 15.2 21.1 21.3 18.9 21.5 22.2 20.3 13.6 22.0 17.1 17.1 22.5 22.4 22.2 22.3 22.4 23.1 20.8 13.4 18.4 19.4 15.6 21.0 16.3 18.0 21.6 20.0 20.9 22.3 20.3 22.4 17.9 22.3 22.9

32 22 15 8 0 0 0 0 0 24 94 54 17 16 4 1 2 8 16 18 19 116 25 95 4 34 0 5 25 17 12 84 164 21 8 11 31 2 0 44 23 0 7 2 14 3 6 1 1 2 2

0 0 0 0 2 4 7 1 2 0 0 0 0 0 2 0 0 2 17 0 0 0 0 0 0 0 2 3 32 0 3 0 0 0 0 0 0 0 2 0 4 12 0 10 2 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,388.79 1,165.58 1,994.85 1,246.68 3,160.32 2,816.24 1,897.02 2,016.89 2,998.33 748.44 1,154.65 971.53 855.51 1,164.65 2,242.92 764.39 730.42 1,205.70 1,574.74 720.42 1,739.75 1,323.62 1,009.50 1,051.59 1,651.66 1,295.65 2,870.24 1,708.71 1,372.73 987.52 1,378.73 1,389.74 1,629.80 820.47 1,547.70 1,102.43 1,786.77 976.44 2,666.13 1,212.67 1,602.92 2,963.59 1,642.77 1,824.81 2,350.14 1,390.68 1,988.89 1,132.56 1,857.03 1,548.83 1,315.69

Table S1 page 89/159

Rab GDP dissociation inhibitor beta GDIB_HUMAN GDI2

50,648

100.00%

23

27

108

QAVEQQIQSHR SAEIDSDDTGGSAAQK 60.00% DLGTESQIFISR DWNVDLIPK EIRPALELLEPIEQK EPEKEIRPALELLEPIEQK FKIPGSPPESMGR FLMANGQLVK FVSISDLLVPK GRDWNVDLIPK IPGSPPESMGR LSAIYGGTYMLNKPIEEIIVQNGK

22,641

100.00%

3

3

4

16.80%

DNA-(apurinic or apyrimidinic site) APEX1_HUMAN APEX1 lyase

35,538

100.00%

12

14

96

47.20%

Calnexin

CALX_HUMAN CANX

67,552

100.00%

2

2

2

5.24%

High mobility group protein B3

HMGB3_HUMAN HMGB3

22,963

100.00%

6

6

21

29.50%

DnaJ homolog subfamily C member DNJC8_HUMAN DNAJC8 8 COF1_HUMAN CFL1 Cofilin-1

29,824

99.90%

2

2

6

10.70%

18,485

100.00%

9

11

172

66.30%

Prefoldin subunit 3

PFD3_HUMAN VBP1

LYSESLAR MLLYTEVTR MTGSEFDFEEMKR NPYYGGESASITPLEDLYK NPYYGGESASITPLEDLYKR NTNDANSCQIIIPQNQVNR QLICDPSYVK SPYLYPLYGLGELPQGFAR TDDYLDQPCYETINR TYDATTHFETTCDDIK VICILSHPIK VPSTEAEALASSLMGLFEK VTEGSFVYK KLDEQYQK NLDSLEEDLDFLR QPGNETADTVLK EAAGEGPALYEDPPDQK EGYSGVGLLSR GAVAEDGDELR GAVAEDGDELRTEPEAK ICSWNVDGLR LDYFLLSHSLLPALCDSK LPAELQELPGLSHQYWSAPSDK NAGFTPQER NDKEAAGEGPALYEDPPDQK QGFGELLQAVPLADSFR TSPSGKPATLK VSYGIGDEEHDQEGR APVPTGEVYFADSFDR KIPNPDFFEDLEPFR KLGEMWNNLNDSEK KNPEVPVNFAEFSK LGEMWNNLNDSEK LGEMWNNLNDSEKQPYITK MSAYAFFVQTCR STNPGISIGDVAK EGKPTIVEEDDPELFK QREEEIEAQEK AVLFCLSEDKK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

31.7 71.5 80.0 43.3 44.8 23.5 39.5 43.4 65.7 36.0 43.3 53.7 55.9 53.4 62.2 119.0 113.0 59.4 32.8 98.6 97.4 66.4 37.9 103.0 44.1 33.5 45.3 43.2 76.3 70.3 36.2 85.5 39.8 45.9 57.0 45.0 44.8 89.8 31.5 81.7 82.3 32.5 73.0 40.0 74.0 40.7 91.7 97.2 57.9 38.6 65.1

22.6 18.8 22.6 21.6 16.1 17.9 23.4 22.8 16.5 21.5 21.1 19.3 20.3 23.0 17.3 22.1 21.6 21.9 23.3 21.6 18.1 17.8 18.4 22.6 21.8 21.9 22.6 21.9 20.6 22.8 20.2 21.5 21.8 21.1 20.9 22.8 21.0 21.6 21.2 17.4 21.5 22.6 22.7 22.3 19.5 22.1 21.0 23.0 22.3 20.8 22.5

0 3 6 2 0 0 3 6 6 1 2 0 6 13 3 6 2 1 1 8 2 2 2 14 3 2 1 1 5 11 2 4 2 1 0 8 0 41 2 10 1 0 2 2 5 0 2 8 2 4 2

1 0 0 0 2 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 0 2 1 9 0 0 0 0 0 0 0 3 0 0 4 0 2 0 0 1 0 1 0 0 0 2 0 0 0 0 0

0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,323.68 1,551.68 1,365.70 1,099.58 1,778.01 2,261.24 1,418.71 1,136.61 1,217.71 1,312.70 1,143.55 2,667.41 938.49 1,125.60 1,622.68 2,117.01 2,273.11 2,199.06 1,222.61 2,141.11 1,902.82 1,917.82 1,179.69 1,980.00 1,029.53 1,051.54 1,578.77 1,272.64 1,786.81 1,137.59 1,131.53 1,786.85 1,219.59 2,092.08 2,466.23 1,019.49 2,143.98 1,847.97 1,086.62 1,690.73 1,770.83 1,863.93 1,677.79 1,605.83 1,565.69 2,280.10 1,496.67 1,258.66 1,845.91 1,388.67 1,309.68

Table S1 page 90/159

EILVGDVGQTVDDPYATFVK HELQANCYEEVKDR KEDLVFIFWAPESAPLK LGGSAVISLEGKPL MIYASSK MLPDKDCR NIILEEGKEILVGDVGQTVDDPYATFVK

WD repeat-containing protein 5

WDR5_HUMAN WDR5

36,571

100.00%

4

4

6

Eukaryotic translation initiation factor 3 subunit K

EIF3K_HUMAN EIF3K

25,042

100.00%

3

3

6

60S acidic ribosomal protein P2

RLA2_HUMAN RPLP2

11,647

100.00%

2

2

4

UV excision repair protein RAD23 homolog B

RD23B_HUMAN RAD23B

43,153

100.00%

3

5

11

Serglycin

SRGN_HUMAN SRGN

17,635

100.00%

3

3

11

Alpha-soluble NSF attachment protein

SNAA_HUMAN NAPA

33,216

100.00%

3

3

6

Zyxin

ZYX_HUMAN ZYX

61,258

100.00%

3

3

6

19,962

100.00%

5

5

13

YALYDATYETK 17.10% FSPNGEWLASSSADK TLIDDDNPPVSFVK TLPAHSDPVSAVHFNR YILAATLDNTLK 18.80% ENAYDLEANLAVLK WLLAEMLGDLSDSQLK YNPENLATLER 39.10% LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK NIEDVIAQGIGK 13.90% NQPQFQQMR QEKPAEKPAETPVATSPTATDSTSGDSSR

Anterior gradient protein 2 homolog AGR2_HUMAN AGR2

26S proteasome non-ATPase regulatory subunit 5

PSMD5_HUMAN PSMD5

56,179

100.00%

3

3

8

General vesicular transport factor p115 Epidermal growth factor receptor

USO1_HUMAN USO1

107,880

100.00%

2

2

4

EGFR_HUMAN EGFR

134,261

100.00%

7

9

36

Alpha-N-acetylglucosaminidase

ANAG_HUMAN NAGLU

82,150

100.00%

5

6

12

QIIQQNPSLLPALLQQIGR 20.90% CNPDSNSANCLEEK GPMFELLPGESNK IQDLNR 13.90% EAEAMALLAEAER NSQSFFSGLFGGSSK VAGYAALLEQYQK 7.52% FSPGAPGGSGSQPNQK GPPASSPAPAPK QHPVPPPAQNQNQVR 26.90% HLSPDGQYVPR IMFVDPSLTVR LPQTLSR LYAYEPADTALLLDNMK LYAYEPADTALLLDNMKK 10.70% IVENSDAVTEILNNAELLK TYLSEGPYYVKPVSTTAVEGAE VFTAIANQPWAQK 2.29% IVAFENAFER NDGVLLLQALTR 7.19% EISDGDVIISGNK GDSFTHTPPLDPQELDILK IICAQQCSGR IPLENLQIIR LTQLGTFEDHFLSLQR NLQEILHGAVR NYDLSFLK 10.20% AGGVLAYELLPALDEVLASDSR FLLGSWLEQAR LLLTSAPSLATSPAFR LPRPLPAVPGELTEATPNR YDLLDLTR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

113.0 58.2 79.6 91.4 37.6 33.2 107.0 72.4 76.9 77.7 38.3 69.5 38.8 80.8 56.2 33.5 77.3 33.0 64.8 97.4 74.7 57.5 30.3 77.4 115.0 66.1 53.9 39.3 57.2 38.7 56.0 35.4 94.2 75.9 96.4 50.4 85.0 36.3 61.5 43.2 45.7 42.7 64.8 46.2 53.7 47.5 51.0 53.8 65.7 32.8 31.2

21.6 21.4 19.5 18.0 20.3 20.8 19.1 22.2 21.3 23.2 22.5 20.0 23.0 22.4 22.7 20.0 22.2 22.0 20.9 11.1 13.4 22.9 22.6 22.3 22.4 21.9 21.4 23.3 21.2 22.2 22.3 20.8 22.5 22.5 19.9 21.6 22.0 22.1 19.3 23.9 21.6 21.8 14.3 22.2 20.1 20.9 19.7 22.1 17.9 17.0 21.4

10 0 7 61 1 1 0 8 2 2 0 1 2 2 2 0 2 2 0 5 4 6 1 2 2 2 1 1 0 2 4 2 4 1 4 2 2 2 2 5 2 2 9 2 2 4 2 4 3 0 1

0 13 11 0 0 0 57 0 0 0 1 0 0 0 0 2 0 0 2 1 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 9 0 0 1 0 0 1 0 0 1 0

0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,166.10 1,790.81 1,990.07 1,340.78 815.40 1,050.47 3,062.59 1,337.63 1,595.73 1,559.80 1,747.89 1,335.75 1,562.81 1,834.93 1,319.66 2,774.43 1,256.69 1,192.55 2,945.40 2,130.24 1,637.65 1,418.70 758.42 1,403.68 1,549.73 1,453.77 1,515.72 1,076.57 1,709.88 1,268.64 1,293.69 814.48 1,940.97 2,069.06 2,085.11 2,361.15 1,473.79 1,195.61 1,312.76 1,346.68 2,123.07 1,192.56 1,208.74 1,904.99 1,249.70 999.52 2,259.19 1,319.71 1,644.93 2,028.12 1,008.54

Table S1 page 91/159

PDZ and LIM domain protein 1

PDLI1_HUMAN PDLIM1

36,053

100.00%

11

12

28

48.60% CGTGIVGVFVK DFEQPLAISR ERVTPPEGYEVVTVFPK LVGGKDFEQPLAISR MNLASEPQEVLHIGSAHNR SAMPFTASPASSTTAR TAASGVEANSRPLDHAQPPSSLVIDKESEVYK

VAASIGNAQK VITNQYNNPAGLYSSENISNFNNALESK

Lysozyme C

LYSC_HUMAN LYZ

16,519

100.00%

2

2

9

Stress-induced-phosphoprotein 1

STIP1_HUMAN STIP1

62,624

100.00%

21

24

67

ADP-sugar pyrophosphatase

NUDT5_HUMAN NUDT5

24,310

100.00%

5

6

15

EH domain-containing protein 4

EHD4_HUMAN EHD4

61,160

100.00%

3

3

5

Carcinoembryonic antigen-related cell adhesion molecule 5

CEAM5_HUMAN CEACAM5

76,778

99.50%

2

2

12

Lamin-A/C

LMNA_HUMAN LMNA

74,123

100.00%

27

32

213

VTPPEGYEVVTVFPK VWSPLVTEEGKR 27.00% STDYGIFQINSR TPGAVNACHLSCSALLQDNIADAVACAK

40.70% AAALEFLNR ALSVGNIDDALQCYSEAIK AMADPEVQQIMSDPAMR AMDVYQK DPQALSEHLKNPVIAQK EAADGYQR EGLQNMEAR ELDPTNMTYITNQAAVYFEK ELGNDAYK ETKPEPMEEDLPENKK FMNPFNMPNLYQK HDSPEDVKR HEANNPQLK IGNSYFKEEK ILKEQER KAAALEFLNR LAYINPDLALEEK LDPHNHVLYSNR LMDVGLIAIR NPVIAQK TYEEGLKHEANNPQLK 23.30% EQTADGVAVIPVLQR HANAKPFEVPFLK KEQTADGVAVIPVLQR QYIISEELISEGK TTYMDPTGK 5.91% EYQISAGDFPEVK FGNAFLNR LFEAEAQDLFR 6.13% QIIGYVIGTQQATPGPAYSGR SDLVNEEATGQFR TLTLLSVTR 43.50% AAYEAELGDAR AAYEAELGDARK AGQVVTIWAAGAGATHSPPTDLVWK

AQHEDQVEQYKK EAALSTALSEKR IDSLSAQLSQLQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

58.0 43.0 39.9 74.2 35.2 91.2 22.4 63.2 51.0 43.6 57.6 86.2 58.8 59.5 110.0 95.9 33.4 39.4 38.0 44.3 82.4 33.8 38.1 33.2 36.3 41.6 56.4 38.5 29.9 70.5 38.3 70.8 45.0 52.6 89.5 33.4 85.6 59.6 35.3 35.1 40.3 50.0 102.0 68.5 64.0 59.7 39.3 53.4 46.5 57.5 84.6

22.7 23.6 21.5 20.9 22.2 22.2 20.3 22.5 21.0 21.0 21.9 21.3 20.6 23.5 21.8 17.9 19.5 19.2 20.9 19.3 20.5 21.8 21.6 21.0 22.6 23.2 22.5 23.4 20.6 22.5 22.4 20.8 17.2 22.0 19.5 20.5 16.9 22.6 18.6 22.6 22.3 21.8 20.1 21.5 13.2 22.3 23.2 19.5 21.8 22.0 20.7

2 3 0 2 0 5 0 3 0 3 2 6 0 2 2 2 1 0 2 5 4 1 1 1 0 2 2 2 0 12 2 10 2 2 2 0 3 3 1 2 1 2 4 8 25 2 2 0 0 6 15

0 0 1 2 0 0 0 0 2 0 0 0 3 0 0 0 0 2 0 0 0 0 3 0 2 0 0 0 1 0 0 0 0 2 0 2 4 0 0 0 0 0 0 0 0 0 0 2 5 0 0

0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,136.61 1,175.61 1,947.02 1,629.90 2,119.04 1,598.75 3,395.71 958.53 3,101.48 1,661.88 1,400.75 1,400.68 2,927.38 1,004.55 2,067.01 1,937.84 870.40 1,888.03 909.41 1,063.48 2,364.11 909.43 1,913.92 1,659.77 1,082.52 1,050.53 1,214.61 915.53 1,132.65 1,488.80 1,464.73 1,100.65 769.46 1,870.93 1,595.88 1,497.82 1,723.97 1,508.79 1,029.46 1,482.71 938.48 1,338.67 2,177.14 1,465.69 1,003.62 1,165.55 1,293.64 2,533.32 1,502.72 1,275.69 1,430.79

Table S1 page 92/159

62,066

100.00%

5

5

21

COP9 signalosome complex subunit CSN4_HUMAN COPS4 4

46,252

100.00%

3

3

6

VPS29_HUMAN VPS29

20,488

99.50%

2

3

5

CLH1_HUMAN CLTC

191,601

100.00%

32

35

130

N-acetylglucosamine-6-sulfatase

Vacuolar protein sorting-associated protein 29 Clathrin heavy chain 1

GNS_HUMAN GNS

IRIDSLSAQLSQLQK ITESEEVVSR KLESTESR LADALQELR LAVYIDR LEAALGEAK LKDLEALLNSK LLEGEEER LQEKEDLQELNDR LQTMKEELDFQK LRDLEDSLAR LSPSPTSQR MQQQLDEYQELLDIK NSNLVGAAHEELQQSR QNGDDPLLTYR SGAQASSTPLSPTR SNEDQSMGNWQIK TALINSTGEEVAMR TLEGELHDLR VAVEEVDEEGK VAVEEVDEEGKFVR 10.10% AFQNVFAPR IQEPNTFPAILR SDVLVEYQGEGR TPGVFDPGYR WQTLLSVDDLVEK 9.36% IASQMITEGR NAAQVLVGIPLETGQK VISFEEQVASIR 12.60% GDFDENLNYPEQK TLAGDVHIVR 24.30% ADDPSSYMEVVQAANTSGNWEELVK AFMTADLPNELIELLEK ALEHFTDLYDIKR AYEFAER DAMQYASESK ENPYYDSR FNALFAQGNYSEAAK GQCDLELINVCNENSLFK GQFSTDELVAEVEK HELIEFR IAAYLFK ISGETIFVTAPHEATAGIIGVNR IVLDNSVFSEHR IYIDSNNNPER KFNALFAQGNYSEAAK LAELEEFINGPNNAHIQQVGDR LASTLVHLGEYQAAVDGAR LEKHELIEFR LLLPWLEAR LLYNNVSNFGR

95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

40.4 90.0 59.2 76.1 30.2 37.0 60.2 39.2 87.4 44.9 32.6 36.3 105.0 101.0 42.9 71.2 54.1 77.5 47.2 62.5 77.9 51.9 59.9 47.5 37.6 79.1 46.6 58.1 61.4 43.7 44.5 40.7 40.7 38.4 39.5 47.5 30.9 56.5 45.5 98.2 39.3 31.8 52.4 89.7 53.9 37.2 57.2 49.2 33.3 40.3 72.7

16.9 23.4 22.1 22.6 20.6 21.7 19.0 21.6 22.1 22.7 22.8 21.4 22.6 22.1 22.6 22.6 19.2 22.9 22.4 21.6 22.5 23.2 20.3 22.3 22.4 23.3 24.1 18.2 22.0 19.5 19.1 19.1 22.3 22.8 19.1 15.2 17.9 22.2 21.7 23.4 20.5 19.0 18.9 21.6 22.4 22.6 21.5 21.4 20.8 15.8 22.4

0 19 5 4 1 2 11 2 15 4 1 2 23 8 1 15 2 13 7 4 6 2 10 2 3 4 2 2 2 2 2 1 2 0 2 2 1 1 1 2 1 1 0 1 12 0 0 0 0 7 7

2 0 0 0 0 0 2 0 17 0 1 0 0 10 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 0 0 0 10 4 0 1 5 11 2 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,699.97 1,148.58 949.50 1,028.57 849.48 901.50 1,243.73 974.48 1,629.81 1,525.76 1,187.64 972.51 1,909.92 1,752.86 1,291.63 1,359.69 1,552.67 1,507.74 1,182.61 1,203.57 1,605.81 1,049.55 1,398.77 1,351.65 1,108.54 1,545.82 1,121.56 1,637.92 1,377.74 1,568.69 1,080.62 2,756.24 1,963.01 1,620.84 885.41 1,145.48 1,043.44 1,630.79 2,153.00 1,551.75 943.50 825.49 2,353.25 1,415.73 1,334.63 1,758.88 2,464.22 1,971.03 1,313.72 1,110.67 1,296.67

Table S1 page 93/159

Annexin A4

ANXA4_HUMAN ANXA4

35,866

100.00%

11

11

54

42.00%

Fumarate hydratase, mitochondrial

FUMH_HUMAN FH

54,620

100.00%

4

4

7

9.41%

Proteasome subunit beta type-7

PSB7_HUMAN PSMB7

29,948

100.00%

6

8

24

22.70%

Coatomer subunit alpha

COPA_HUMAN COPA

138,331

100.00%

4

4

6

4.08%

Beta-hexosaminidase subunit beta

HEXB_HUMAN HEXB

63,095

100.00%

8

10

34

18.90%

DNA-binding protein A

DBPA_HUMAN CSDA

40,071

100.00%

3

3

6

20.70%

NLQNLLILTAIK NNLAGAEELFAR NNRPSEGPLQTR RPISADSAIMNPASK SVNESLNNLFITEEDYQALR TLQIFNIEMK TSIDAYDNFDNISLAQR VGYTPDWIFLLR VIQCFAETGQVQK VMEYINR VVGAMQLYSVDR WLLLTGISAQQNR AASGFNAMEDAQTLR AASGFNAMEDAQTLRK AEIDMLDIR DEGNYLDDALVR GAGTDEGCLIEILASR GLGTDDNTLIR GLGTDEDAIISVLAYR ISQTYQQQYGR QDAQDLYEAGEK SDTSFMFQR SETSGSFEDALLAIVK TPEEIR AAAEVNQDYGLDPK IANDIR IGGVTER SGLGELILPENEPGSSIMPGK ATEGMVVADK DGIVLGADTR FRPDMEEEEAK ITPLEIEVLEETVQTMDTS LDFLRPYTVPNK LDFLRPYTVPNKK DADSITLFDVQQK LLELGPKPEVAQQTR SILLSVPLLVVDNK TALNLFFK EISEVFPDQFIHLGGDEVEFK GSIVWQEVFDDK GSYSLSHVYTPNDVR KLESFYIQK LAPGTIVEVWK VEPLDFGGTQK VLDIIATINK VLPEFDTPGHTLSWGK AGEAPTENPAPPTQQSSAE GAEAANVTGPDGVPVEGSR NDTKEDVFVHQTAIK NPTYRPR SVGDGETVEFDVVEGEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

87.7 93.1 44.4 59.4 113.0 53.5 114.0 32.9 91.1 38.2 67.8 87.9 119.0 75.2 59.3 60.7 103.0 55.4 103.0 63.6 55.8 65.0 107.0 40.6 62.8 32.4 42.7 46.1 33.7 33.7 50.1 58.4 35.5 30.6 51.0 32.1 47.5 37.9 52.4 56.6 63.3 30.5 49.0 30.5 62.2 61.7 64.4 65.3 35.6 31.9 45.0

10.0 23.5 23.3 23.3 21.6 22.0 22.0 21.4 22.6 22.1 22.5 20.0 21.8 22.2 24.4 21.3 22.9 23.5 21.4 21.6 19.1 18.5 21.7 20.7 22.0 22.7 25.1 22.2 23.1 22.3 18.2 22.1 20.4 15.8 22.7 16.6 11.5 20.2 21.4 22.0 22.5 20.6 18.3 23.7 18.0 21.8 20.3 22.9 22.7 23.9 21.7

10 7 2 2 2 6 3 1 2 2 4 4 4 2 4 2 2 2 10 5 2 5 16 1 2 2 1 2 2 3 10 2 1 0 1 0 1 2 1 6 6 1 6 1 7 4 1 4 0 1 2

0 0 7 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 3 1 0 2 0 0 1 0 1 0 0 0 0 0 0 0 2 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,353.85 1,304.66 1,368.70 1,573.80 2,355.15 1,252.66 1,942.91 1,479.80 1,507.76 940.46 1,337.69 1,499.83 1,581.73 1,725.82 1,091.54 1,379.64 1,661.82 1,174.61 1,692.88 1,371.67 1,366.61 1,118.49 1,666.85 744.39 1,490.71 701.39 731.41 2,141.08 1,020.50 1,016.54 1,396.61 2,164.06 1,462.81 1,590.90 1,479.73 1,678.95 1,509.93 953.55 2,435.18 1,422.69 1,694.81 1,155.64 1,212.70 1,190.61 1,099.67 1,783.90 1,881.85 1,782.86 1,744.89 903.48 1,795.82

Table S1 page 94/159

F-actin-capping protein subunit beta CAPZB_HUMAN CAPZB

31,334

100.00%

6

6

51

Superoxide dismutase [Mn], mitochondrial

SODM_HUMAN SOD2

24,705

100.00%

4

4

19

Heat shock protein 105 kDa

HS105_HUMAN HSPH1

96,848

100.00%

19

22

52

Proteasome-associated protein ECM29 homolog Farnesyl pyrophosphate synthase

ECM29_HUMAN ECM29

204,278

99.90%

2

2

3

FPPS_HUMAN FDPS

48,259

100.00%

8

10

41

Sorbitol dehydrogenase

DHSO_HUMAN SORD

38,307

100.00%

3

3

7

Disintegrin and metalloproteinase domain-containing protein 10

ADA10_HUMAN ADAM10

84,125

100.00%

3

3

7

DCN1-like protein 1

DCNL1_HUMAN DCUN1D1

30,108

100.00%

5

5

7

23.80% LEVEANNAFDQYR RLPPQQIEK SGSGTMNLGGSLTR SPWSNKYDPPLEDGAMPSAR STLNEIYFGK YDPPLEDGAMPSAR 19.80% AIWNVINWENVTER GDVTAQIALQPALK GELLEAIKR YQEALAK 27.00% AFNDPFIQK DLLNMYIETEGK EKENLSYDLVPLK ENLSYDLVPLK FQEAEERPK FVVQNVSAQK GCALQCAILSPAFK IEVPLYSLLEQTHLK KVDQPPEAK LKETAENSLK LLTETEDWLYEEGEDQAK MFEELGQR NAVEEYVYEFR NQQITHANNTVSNFK QAYVDKLEELMK QDLPSLDEKPR SQFEELCAELLQK SVLDAAQIVGLNCLR VEDVSAVEIVGGATR VLGTAFDPFLGGK 1.63% AGEQLAPFLPQLVPR TLMSSGQMAPSSSNK 19.60% ATPEQYQILK CSWLVVQCLQR EVLEYNAIGGK IGTDIQDNK KQDADSLQR LKEVLEYNAIGGK QDFVQHFSQIVR VLTEDEMGHPEIGDAIAR 11.80% AMGAAQVVVTDLSATR LENYPIPEPGPNEVLLR VAIEPGAPR 4.55% AIDTIYQTTDFSGIR FPNIGVEK GGTFYVEPAER 20.80% FLDLWNK LDVATDNFFQNPELYIR MEQELKEPGR QFMIFTQSSEK YKDPQDENK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

94.7 44.1 89.8 41.4 76.9 50.1 71.2 70.7 50.6 43.4 42.6 52.4 76.8 53.1 42.6 68.8 37.1 61.3 36.9 32.6 115.0 37.5 32.6 88.2 51.6 29.9 40.1 81.1 89.5 67.8 37.2 72.0 43.5 44.5 47.2 44.6 51.2 53.4 42.3 75.2 120.0 67.0 33.3 74.4 49.0 36.4 30.4 81.3 31.7 50.5 30.4

21.9 18.8 21.5 20.5 22.8 20.0 22.6 16.7 19.6 22.4 23.1 21.6 21.4 22.3 23.1 23.0 22.6 18.0 20.5 22.6 21.1 21.6 21.4 22.0 22.3 22.0 22.7 20.8 22.9 21.2 16.8 18.3 22.5 23.2 23.3 22.8 24.4 19.7 22.9 22.0 22.4 20.6 19.2 22.4 22.7 21.9 23.3 23.4 21.5 22.5 22.4

4 4 17 0 18 1 8 4 5 2 4 2 2 1 5 2 1 2 2 1 2 2 2 2 2 0 2 2 4 6 2 1 4 2 2 4 3 2 0 5 4 2 1 4 2 1 1 2 0 2 1

0 0 0 7 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 1 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 2 9 8 0 0 0 0 0 0 0 0 1 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,568.73 1,108.65 1,337.65 2,234.02 1,171.60 1,518.69 1,743.88 1,424.81 1,028.61 822.44 1,079.55 1,441.69 1,547.83 1,290.69 1,133.56 1,119.62 1,535.77 1,783.00 1,011.55 1,132.62 2,168.99 1,009.48 1,418.66 1,715.85 1,482.75 1,297.68 1,594.78 1,628.88 1,501.79 1,321.72 1,635.92 1,557.69 1,190.64 1,448.71 1,192.62 1,003.51 1,060.54 1,433.80 1,503.77 1,952.94 1,605.83 1,950.03 909.52 1,700.85 903.49 1,225.59 935.50 2,055.02 1,232.59 1,345.65 1,136.52

Table S1 page 95/159

Serpin B5

SPB5_HUMAN SERPINB5

42,084

100.00%

14

16

63

Alcohol dehydrogenase [NADP+]

AK1A1_HUMAN AKR1A1

36,556

100.00%

11

13

94

48.50% ACLENLGLK DELNADHPFIYIIR DLTDGHFENILADNSVNDQTK DVEDESTGLEK DVPFGFQTVTSDVNK ELETVDFK GDTANEIGQVLHFENVK GQINNSIK HIFSEDTSDFSGMSETK IIELPFQNK ILVVNAAYFVGK LSSFYSLK QLNSESLSQWTNPSTMANAK SLNLSTEFISSTK 36.60% ALEALVAK AVPREELFVTSK AWRDPDEPVLLEEPVVLALAEK

Laminin subunit beta-1

LAMB1_HUMAN LAMB1

198,045

100.00%

28

31

217

DPDEPVLLEEPVVLALAEK GLEVTAYSPLGSSDR GLVQALGLSNFNSR MPLIGLGTWK QLNALNK SPAQILLR VFDFTFSPEEMK YIVPMLTVDGK 17.40% AAQNSGEAEYIEK AEMLLEEAKR AMDLDQDVLSALAEVEQLSK ATGQCLCLPNVIGQNCDR AVITVQRPGR DILAQSPAAEPLK DRVEDVMMER DVTEMMAQVEVK EALEEAEK ELAEQLEFIK ELDSLQTEAESLDNTVK ETVDSVER IEDPYSPR IPSWTGAGFVR IQNLLK ISELER ISGVIGPYR KAAQNSGEAEYIEK LEGEVR LHTLGDNLLDSR NFLTQDSADLDSIEAVANEVLK QSAEDILLK QYIQDR TLDGELDEKYK TPMTDVCR VESLSQVEVILQHSAADIAR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

31.7 71.1 80.4 63.3 105.0 34.2 74.5 36.6 65.0 46.8 39.1 30.1 106.0 82.6 50.8 35.8 71.4 109.0 90.2 72.9 53.7 42.7 60.5 71.4 35.7 83.1 46.8 90.1 95.3 29.9 62.0 28.4 48.2 32.0 57.1 142.0 60.0 35.7 47.8 35.8 35.8 58.3 61.9 33.4 61.1 88.2 52.5 30.4 38.6 53.5 54.2

23.8 21.9 20.6 19.7 22.4 22.1 22.4 24.0 16.1 21.4 16.0 23.8 21.2 22.0 17.2 21.2 19.4 20.7 23.3 22.0 20.5 21.7 15.3 20.2 21.7 20.8 23.9 22.2 20.4 17.6 19.5 18.1 20.5 21.4 22.8 23.0 23.1 22.3 22.0 19.0 24.3 21.2 22.8 22.7 22.0 21.4 22.3 23.4 22.7 18.6 18.3

1 2 2 4 14 1 6 1 3 6 2 1 4 2 2 2 0 9 10 2 28 2 8 8 2 25 2 2 7 0 4 0 3 2 13 20 17 4 12 3 2 20 4 4 5 2 9 1 2 5 0

0 0 6 0 0 0 8 0 0 0 0 0 0 0 0 0 18 2 0 1 0 0 0 0 0 0 0 2 0 6 0 2 0 0 0 0 0 0 0 0 0 0 10 0 2 0 0 0 0 0 6

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,017.54 1,715.88 2,346.09 1,221.55 1,653.81 980.49 1,870.93 873.48 1,933.81 1,101.63 1,293.76 944.51 2,207.04 1,426.74 814.50 1,375.76 2,489.33 2,076.11 1,551.77 1,475.80 1,115.63 800.46 897.55 1,492.67 1,251.67 1,409.65 1,205.62 2,191.08 2,075.94 1,096.66 1,352.74 1,311.57 1,411.65 918.44 1,219.66 1,891.91 934.45 976.47 1,190.63 728.47 746.40 961.55 1,537.75 702.38 1,353.71 2,392.19 1,016.56 822.41 1,310.65 995.43 2,165.16

Table S1 page 96/159

Disintegrin and metalloproteinase domain-containing protein 9

ADAM9_HUMAN ADAM9

90,538

100.00%

3

4

14

3.17%

Matrix metalloproteinase-14

MMP14_HUMAN MMP14

65,868

99.90%

2

2

2

4.30%

Proteasome subunit alpha type-5

PSA5_HUMAN PSMA5

26,393

100.00%

8

9

73

46.90%

Annexin A11

ANX11_HUMAN ANXA11

54,374

100.00%

4

4

10

7.92%

78 kDa glucose-regulated protein

GRP78_HUMAN HSPA5

72,317

100.00%

34

42

564

54.40%

YEPQLPDHWEK YSDIEPSTEGEVIFR DLLPEDFVVYTYNK MDDVYKEPLK NKDLLPEDFVVYTYNK SPQSLSAAIAAMQK VGEYATYEAIR AIGSASEGAQSSLQEVYHK EELEEVIKDI GVNTFSPEGR ITSPLMEPSSIEK LFQVEYAIEAIK LGSTAIGIQTSEGVCLAVEK LNATNIELATVQPGQNFHMFTK SSLIILK DAQELYAAGENR FNAVLCSR SETDLLDIR TPVLFDIYEIK AKFEELNMDLFR ALSSQHQAR DAGTIAGLNVMR DNHLLGTFDLTGIPPAPR EFFNGKEPSR ELEEIVQPIISK FEELNMDLFR IEIESFYEGEDFSETLTR IEWLESHQDADIEDFK IEWLESHQDADIEDFKAK IINEPTAAAIAYGLDK IINEPTAAAIAYGLDKR ITITNDQNR ITPSYVAFTPEGER KSDIDEIVLVGGSTR KSQIFSTASDNQPTVTIK KVTHAVVTVPAYFNDAQR LSSEDKETMEK LYGSAGPPPTGEEDTAEKDEL MKETAEAYLGK NELESYAYSLK NQLTSNPENTVFDAK NQLTSNPENTVFDAKR RALSSQHQAR SDIDEIVLVGGSTR SQIFSTASDNQPTVTIK STMKPVQK TFAPEEISAMVLTK TKPYIQVDIGGGQTK TWNDPSVQQDIK VEIIANDQGNR VLEDSDLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

32.8 68.5 51.3 48.5 71.4 70.8 65.9 125.0 57.6 52.4 73.7 89.6 40.8 71.0 67.5 49.8 59.5 38.0 66.2 84.0 61.1 106.0 97.6 54.1 73.3 49.5 99.4 97.4 60.3 114.0 110.0 63.0 85.5 124.0 90.9 29.0 52.5 110.0 59.6 77.4 104.0 93.9 50.3 77.2 103.0 31.9 99.5 65.5 71.4 80.0 30.6

21.5 21.7 22.0 23.0 21.6 23.0 21.9 21.8 23.4 23.3 23.8 19.5 21.1 21.2 12.0 21.1 23.2 23.9 20.4 22.4 21.6 23.6 22.2 22.4 18.9 20.8 20.4 20.9 20.8 21.5 19.3 23.3 22.4 22.3 20.5 20.0 21.6 21.0 22.0 22.1 22.9 21.8 21.7 22.6 22.0 23.1 22.8 20.9 22.4 22.6 23.9

2 19 6 3 4 1 1 7 3 4 11 23 2 0 12 1 6 1 2 22 4 19 20 3 26 7 9 5 0 30 21 14 33 21 2 0 6 26 9 22 26 2 0 10 39 1 44 4 24 56 1

0 0 0 0 1 0 0 5 0 0 0 0 0 6 0 0 0 0 0 12 0 0 18 0 0 0 0 4 10 4 19 0 0 13 2 2 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,441.68 1,741.83 1,715.85 1,237.61 1,957.99 1,402.74 1,271.63 1,961.96 1,216.63 1,063.52 1,431.74 1,423.78 2,033.06 2,474.25 773.51 1,336.61 966.48 1,061.55 1,337.74 1,512.75 997.52 1,217.63 1,934.01 1,210.59 1,397.79 1,329.62 2,164.99 1,974.91 2,174.04 1,659.90 1,816.00 1,074.55 1,566.78 1,588.85 1,965.03 2,016.07 1,296.60 2,175.99 1,256.62 1,316.64 1,677.81 1,833.91 1,153.62 1,460.76 1,836.93 918.51 1,536.80 1,604.87 1,430.69 1,228.63 918.48

Table S1 page 97/159

Aminoacyl tRNA synthase complex- AIMP1_HUMAN AIMP1 interacting multifunctional protein 1

34,335

100.00%

6

8

18

25.60%

Peroxiredoxin-2

PRDX2_HUMAN PRDX2

21,874

100.00%

7

8

42

35.90%

Gamma-glutamyl hydrolase

GGH_HUMAN GGH

35,948

100.00%

7

9

56

26.10%

31,370

100.00%

4

4

11

21.70%

Enoyl-CoA hydratase, mitochondrial ECHM_HUMAN ECHS1

26S proteasome non-ATPase regulatory subunit 12 CD166 antigen

PSD12_HUMAN PSMD12

52,888

100.00%

2

2

2

4.82%

CD166_HUMAN ALCAM

65,086

100.00%

13

14

95

25.20%

UMP-CMP kinase

KCY_HUMAN CMPK1

22,205

100.00%

8

9

32

55.60%

VLEDSDLKK VMEHFIK VTHAVVTVPAYFNDAQR VYEGERPLTK GAEADQIIEYLK IEILAPPNGSVPGDR ITFDAFPGEPDKELNPK KQQSIAGSADSKPIDVSR QQSIAGSADSKPIDVSR TVVSGLVNHVPLEQMQNR ATAVVDGAFK EGGLGPLNIPLLADVTR GLFIIDGK KEGGLGPLNIPLLADVTR LSEDYGVLK QITVNDLPVGR SVDEALR TDEGIAYR FFNVLTTNTDGK KPIIGILMQK LDLTEKDYEILFK NLDGISHAPNAVK SINGILFPGGSVDLR YLESAGAR YPVYGVQWHPEK ALNALCDGLIDELNQALK AQFAQPEILIGTIPGAGGTQR ICPVETLVEEAIQCAEK ISAQDAK DPNNLLNDWSQK LNSLMSLVNK ADIQMPFTCSVTYYGPSGQK ALFLETEQLK ALFLETEQLKK EMDPVTQLYTMTSTLEYK FVCMLVTEDNVFEAPTIVK LDVPQNLMFGK QIGDALPVSCTISASR SSNTYTLTDVR SSNTYTLTDVRR SVQYDDVPEYK SVQYDDVPEYKDR VFKQPSKPEIVSK YEKPDGSPVFIAFR EMDQTMAANAQK FLIDGFPR IQTYLQSTKPIIDLYEEMGK KNPDSQYGELIEK MKPLVVFVLGGPGAGK NQDNLQGWNK SVDEVFDEVVQIFDKEG

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

42.3 33.3 94.0 53.5 66.0 47.3 62.8 54.0 94.7 52.9 40.6 80.7 33.1 86.1 43.1 82.9 44.8 47.9 72.1 33.4 62.3 78.0 46.5 32.3 33.0 141.0 91.7 97.4 41.4 51.9 31.6 87.3 74.0 37.8 109.0 86.3 59.8 103.0 67.4 40.5 31.7 44.5 37.2 48.8 57.4 58.9 46.0 72.9 71.4 36.0 39.3

23.4 24.2 22.2 22.7 22.8 21.7 22.4 21.0 22.3 21.2 22.9 16.3 18.1 14.9 22.7 21.0 24.9 21.2 22.1 15.1 21.0 22.2 20.8 23.2 22.8 21.8 19.1 21.7 25.4 21.3 21.9 19.4 20.7 17.7 21.0 22.1 22.4 22.7 21.8 22.5 20.6 21.2 17.6 22.3 18.9 22.0 20.9 23.1 16.8 20.6 21.6

6 1 9 15 2 2 2 0 1 0 4 10 2 5 4 23 2 4 10 2 8 11 7 1 0 2 4 4 1 1 1 5 8 3 29 4 11 5 16 1 1 2 0 2 2 11 0 2 1 2 1

0 0 27 0 0 0 2 2 3 4 0 0 0 11 0 0 0 0 0 2 13 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 5 0 0 6 0 4 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,046.57 903.48 1,887.97 1,191.64 1,349.70 1,534.82 1,917.96 1,886.99 1,758.90 2,021.06 978.53 1,734.98 862.50 1,863.07 1,023.54 1,211.68 789.41 924.44 1,356.68 1,156.71 1,626.86 1,335.70 1,544.84 866.44 1,502.74 1,971.02 2,125.14 1,988.97 732.39 1,443.69 1,118.62 2,266.02 1,191.66 1,319.76 2,166.00 2,228.10 1,261.66 1,674.85 1,256.61 1,412.71 1,342.62 1,613.74 1,486.86 1,625.83 1,337.58 964.53 2,386.22 1,520.76 1,585.91 1,216.57 1,954.93

Table S1 page 98/159

Glucosamine-6-phosphate isomerase GNPI1_HUMAN GNPDA1 1

32,651

100.00%

6

7

18

Galactocerebrosidase

GALC_HUMAN GALC

77,019

99.90%

2

2

3

Eukaryotic translation initiation factor 3 subunit E

EIF3E_HUMAN EIF3E

52,205

100.00%

5

5

9

45 kDa calcium-binding protein

CAB45_HUMAN SDF4

41,789

100.00%

12

14

73

Plasminogen activator inhibitor 1

PAI1_HUMAN SERPINE1

45,042

100.00%

17

22

726

YGYTHLSAGELLR 30.10% AIEEGVNHMWTVSAFQQHPR LVDPLYSIK TFNMDEYVGLPR TLAMDTILANAR VPTMALTVGVGTVMDAR YFTLGLPTGSTPLGCYK 4.09% EFDGIGAVSGGGATSR SLWTDIPVNFPK 15.30% LGHVVMGNNAVSPYQQVIEK LKETIDNNSVSSPLQSLQQR LNMTPEEAER MLFDYLADK QEYLDTLYR 31.20% AVDPDGDGHVSWDEYK DLGGFDEDAEPR DLGGFDEDAEPRR EVADAIR GFHQEVFLGK LEMDGHLNR LMVIFSK QMIAVADENQNHHLEPEEVLK TAEHFQEAMEESK VDVNTDR VDVNTDRK YSEFFTGSK 48.30% ELMGPWNKDEISTTDAIFVQR FIINDWVK FSLETEVDLR GAVDQLTR GMAPALR GMISNLLGK HNPTGTVLFMGQVMEP IDDKGMAPALR KPLENLGMTDMFR LVQGFMPHFFR MAPEEIIMDRPFLFVVR QFQADFTSLSDQEPLHVAQALQK

Ras-related protein Ral-A

RALA_HUMAN RALA

23,549

100.00%

2

2

2

Peroxiredoxin-6

PRDX6_HUMAN PRDX6

25,018

100.00%

8

11

38

QVDFSEVER SDGSTVSVPMMAQTNK TPFPDSSTHR VFQQVAQASK VFQQVAQASKDR 14.10% AEQWNVNYVETSAK VKEDENVPFLLVGNK 41.50% DGDSVMVLPTIPEEEAK ELAILLGMLDPAEKDEK LPFPIIDDR LSILYPATTGR PGGLLLGDVAPNFEANTTVGR VATPVDWKDGDSVMVLPTIPEEEAK

95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

29.9 32.0 30.3 75.3 93.6 91.8 72.6 70.7 37.7 32.0 39.6 50.1 38.9 33.3 90.1 82.3 39.9 31.5 40.3 51.8 33.1 48.2 78.9 45.7 34.0 32.3 45.4 51.7 55.6 58.5 35.2 54.8 89.0 57.9 65.8 47.5 36.6 90.9 80.7 60.6 49.4 78.7 50.6 57.4 33.8 54.7 67.6 59.3 59.0 77.2 35.6

22.7 21.8 16.1 20.9 23.3 22.6 22.0 22.0 22.1 21.4 20.6 18.9 20.9 21.8 17.5 16.0 21.2 23.5 24.2 19.9 20.2 22.5 17.8 23.3 23.4 21.2 20.8 22.5 23.2 23.4 25.7 21.4 21.1 23.9 23.2 23.0 21.8 21.1 22.3 20.1 20.6 22.3 22.8 21.9 20.4 22.0 21.2 20.9 19.5 20.3 21.1

0 0 1 8 2 2 2 1 2 0 0 2 2 1 4 13 1 1 2 4 1 0 15 11 3 1 0 24 21 19 3 41 113 13 34 13 0 1 52 57 29 53 2 1 1 5 5 8 3 4 0

3 2 0 0 0 1 0 0 0 2 2 0 0 0 0 0 0 0 0 2 0 7 8 0 0 0 30 0 0 0 0 0 0 9 24 3 17 130 0 0 38 0 0 0 0 0 2 0 0 2 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2

1,479.76 2,353.11 1,047.61 1,457.67 1,289.69 1,749.89 1,874.94 1,480.70 1,416.75 2,199.12 2,257.18 1,205.55 1,131.54 1,200.59 1,789.77 1,320.57 1,476.67 773.42 1,161.61 1,100.52 853.49 2,444.19 1,536.66 818.40 946.50 1,065.49 2,466.20 1,034.57 1,208.62 859.46 731.39 932.52 1,789.83 1,202.62 1,551.77 1,394.70 2,095.07 2,601.30 1,108.53 1,684.75 1,144.54 1,105.60 1,376.73 1,638.78 1,700.92 1,829.88 1,885.00 1,085.60 1,191.67 2,098.09 2,742.36

Table S1 page 99/159

VVFVFGPDK VVFVFGPDKK EAFEETHLTSLDPVK FFTNFESR GEEDWLYER EDTPNSVWEPAK EPTMYVGSTSVQTSR GDSGGAFAVQDPNDKTK SDFSNEER SSNNPHSPIVEEFQVPYNK TMQENSTPRED TNFDNDIALVR FRGPFTDVVTTNLK GPFTDVVTTNLK LGNPTDR ADAEEEAATR DLEDKEGEIQAGAK EAVAPVQEESDLEK SVSTPSEAGSQDSGDGAVGSR DTNGENIAESLVAEGLATR DTPDEPWAFPAR DYVAPTANLDQK EADGSETPEPFAAEAK GDVGLGLVK LGTLSPAFSTR NDIASHPPVEGSYAPR NLPGLVQEGEPFSEEATLFTK QFLPFLQR QINLSNIR SLLSAEEAAK SSHYDELLAAEAR TDAVDSVVR VITEYLNAQESAK VMQVLNADAIVVK

29,970

100.00%

3

3

4

12.30%

76,666

100.00%

7

7

22

13.50%

VAPB_HUMAN VAPB

27,211

100.00%

3

3

3

8.64%

Cytoplasmic dynein 1 intermediate chain 2

DC1I2_HUMAN DYNC1I2

71,438

100.00%

4

4

8

9.25%

Staphylococcal nuclease domaincontaining protein 1

SND1_HUMAN SND1

101,981

100.00%

16

18

44

23.50%

Heme-binding protein 2

HEBP2_HUMAN HEBP2

22,858

100.00%

4

5

24

Latent-transforming growth factor beta-binding protein 2

LTBP2_HUMAN LTBP2

195,025

100.00%

7

7

29

Protein CYR61

CYR61_HUMAN CYR61

42,008

100.00%

4

4

14

26,905

100.00%

14

14

149

23.90% APEDAGPQPGSYEIR NNEVWLIQK NQEQLLTLASILR VYYTAGYNSPVK 4.78% EQDAPVAGLQPVER GAGGQSMSEAPTGDHAPAPTR QICCCSR SSAAGEGTLAR SSGALPGPAER STPLGQQQPAPR VTNDVCSEPLR 13.10% ELGFDASEVELTR GLECNFGASSTALK ILYNPLQGQK IYQNGESFQPNCK 56.80% FLDGNELTLADCNLLPK

Pyridoxine-5'-phosphate oxidase

PNPO_HUMAN PNPO

Complement C1s subcomponent

C1S_HUMAN

Vesicle-associated membrane protein-associated protein B/C

C1S

VNVTVDYIRPASPATETVPAFSER

Chloride intracellular channel protein CLIC1_HUMAN CLIC1

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

30.5 41.2 58.2 52.2 33.7 42.2 78.8 45.7 46.5 31.0 41.0 68.8 29.8 59.7 32.6 74.7 65.3 55.6 103.0 98.2 34.9 45.8 79.3 35.3 37.3 69.0 88.1 39.2 40.3 37.2 46.5 34.4 63.2 76.3 42.2 78.0 55.5 108.0 75.2 52.8 58.8 34.2 59.4 32.1 33.9 36.3 98.3 74.0 35.4 73.1 72.0

21.8 18.9 22.0 21.5 19.0 21.1 21.6 24.1 14.9 21.2 16.1 23.5 20.4 22.0 20.9 18.3 22.4 21.6 20.0 21.8 19.3 23.5 19.2 20.3 21.8 21.6 21.7 20.3 21.8 24.0 22.0 24.7 22.1 19.6 21.1 21.9 22.8 18.5 22.6 23.3 19.7 13.0 22.8 22.0 22.4 22.0 22.6 22.0 21.9 20.5 21.8

1 4 2 1 1 3 3 1 4 0 3 5 0 1 1 2 2 2 2 1 2 2 4 1 2 2 6 6 2 2 2 1 2 4 0 4 4 11 4 3 0 1 3 1 1 1 8 4 1 1 7

0 2 0 0 0 0 0 0 0 3 0 0 1 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 0 0 1 0 0 19 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,007.56 1,135.65 1,715.85 1,047.49 1,196.52 1,372.64 1,642.77 1,706.80 983.41 2,186.05 1,323.55 1,277.65 1,594.86 1,291.69 772.40 1,062.47 1,502.73 1,543.75 1,950.86 1,959.96 1,401.64 1,334.66 1,648.73 857.51 1,149.63 1,709.82 2,306.16 1,048.59 957.55 1,018.54 1,461.70 961.50 1,465.75 1,415.79 2,619.34 1,586.75 1,143.62 1,498.86 1,361.67 1,508.77 2,010.89 983.39 1,019.51 1,041.53 1,279.68 1,289.62 1,465.72 1,454.70 1,173.66 1,584.71 1,932.97

Table S1 page 100/159

1

FSAYIK GFTIPEAFR GVTFNVTTVDTK GVTFNVTTVDTKR IGNCPFSQR KFLDGNELTLADCNLLPK LAALNPESNTAGLDIFAK LFMVLWLK LHIVQVVCK NSNPALNDNLEK VLDNYLTSPLPEEVDETSAEDEGVSQR VLDNYLTSPLPEEVDETSAEDEGVSQRK

Basal cell adhesion molecule

BCAM_HUMAN BCAM

67,386

100.00%

15

18

174

Transgelin-2

TAGL2_HUMAN TAGLN2

22,374

100.00%

12

15

86

Exportin-T

XPOT_HUMAN XPOT

109,949

100.00%

3

3

6

1,4-alpha-glucan-branching enzyme GLGB_HUMAN GBE1

80,445

100.00%

4

4

7

EIF3L_HUMAN EIF3L

66,711

100.00%

7

7

11

Eukaryotic translation initiation factor 3 subunit L

YLSNAYAR 28.70% AGAAGTAEATAR EGDEVTLICSAR EGDTVQLLCR GDGSPSPEYTLFR GRSPPYQLDSQGR LASAEMQGSELQVTMHDTR LEVPVEMNPEGYMTSR LNVFAKPEATEVSPNK LSVPPLVEVMR LSWSQLGGSPAEPIPGR SPPYQLDSQGR TAEIEPK VAYLDPLELSEGK VEDYDAADDVQLSK VTSALSR 67.30% DDGLFSGDPNWFPK DDGLFSGDPNWFPKK DGTVLCELINALYPEGQAPVK DGTVLCELINALYPEGQAPVKK GASQAGMTGYGMPR GPAYGLSR IQASTMAFK NFSDNQLQEGK NVIGLQMGTNR QMEQISQFLQAAER TLMNLGGLAVAR YGINTTDIFQTVDLWEGK 4.26% DLQEFIPLINQITAK LAQVSPELLLASVR NAQEALQAIETK 8.26% IVLDSDAAEYGGHQR LLEIDPYLKPYAVDFQR VALILQNVDLPN YGWLAAPQAYVSEK 17.00% LAGFLDLTEQEFR QLEVYTSGGDPESVAGEYGR QYEQQTYQVIPEVIK VFSDEVQQQAQLSTIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

34.2 44.0 101.0 35.3 53.3 41.1 110.0 52.5 47.3 78.8 44.2 51.0 45.4 104.0 54.6 48.8 63.1 43.0 34.5 86.6 92.1 46.1 85.8 63.1 37.9 61.4 129.0 37.8 58.5 31.6 72.6 48.4 71.7 42.1 41.1 75.7 62.2 95.1 86.6 111.0 39.8 52.3 45.2 113.0 36.1 42.7 48.1 72.0 110.0 55.9 59.4

19.5 22.1 21.6 21.1 23.3 21.5 21.5 18.3 17.9 22.4 19.3 20.1 20.3 23.2 22.2 22.8 21.9 22.9 20.7 20.2 21.4 18.3 21.6 22.9 21.9 22.5 20.3 22.2 20.0 22.2 20.5 21.1 18.1 25.0 21.6 21.0 23.6 22.4 21.5 22.3 18.7 14.3 22.9 22.1 20.4 17.9 22.3 22.5 20.6 21.8 22.2

4 4 21 1 6 1 50 9 4 27 0 0 6 36 3 2 13 2 0 16 8 6 10 14 4 28 14 4 6 1 1 1 14 5 2 10 6 8 11 8 1 4 1 2 0 1 2 2 1 2 1

0 0 0 0 0 0 0 0 0 0 7 2 0 0 0 0 0 2 4 0 7 0 1 0 0 0 0 0 0 1 0 4 0 0 0 0 0 8 0 0 0 0 0 0 2 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

728.40 1,037.54 1,281.67 1,437.77 1,078.51 2,061.07 1,844.98 1,065.62 1,095.64 1,328.64 2,992.39 3,120.49 957.48 1,046.52 1,349.64 1,190.58 1,425.67 1,460.72 2,119.98 1,883.85 1,743.93 1,239.71 1,751.91 1,247.60 787.42 1,433.75 1,567.71 733.42 1,594.72 1,722.81 2,287.16 2,415.26 1,415.60 820.43 1,012.51 1,279.59 1,202.63 1,694.82 1,215.69 2,100.03 1,742.97 1,495.88 1,315.69 1,630.78 2,080.11 1,308.75 1,582.79 1,538.79 2,113.97 1,865.97 1,848.95

Table S1 page 101/159

Exportin-2

XPO2_HUMAN CSE1L

110,404

100.00%

10

10

17

14.30%

Neutrophil gelatinase-associated lipocalin

NGAL_HUMAN LCN2

22,571

100.00%

9

11

135

51.00%

Serpin B7

SPB7_HUMAN SERPINB7

42,888

100.00%

4

4

9

11.30%

RNA-binding protein 8A

RBM8A_HUMAN RBM8A

19,871

99.50%

2

2

5

17.20%

Exportin-7

XPO7_HUMAN XPO7

123,895

99.50%

2

2

3

2.48%

Coatomer subunit gamma

COPG_HUMAN COPG

97,701

100.00%

5

5

9

8.35%

Midkine

MK_HUMAN

15,567

99.50%

2

2

4

11.90%

Polypeptide Nacetylgalactosaminyltransferase 1

GALT1_HUMAN GALNT1

64,202

100.00%

7

7

17

14.70%

AP-1 complex subunit beta-1

AP1B1_HUMAN AP1B1

104,621

99.50%

2

2

2

6.74%

Ubiquitin carboxyl-terminal hydrolase isozyme L3

UCHL3_HUMAN UCHL3

26,165

100.00%

4

5

18

27.40%

MDK

VSGGPSLEQR VYEIQDIYENSWTK VYELQASR ALTLPGSSENEYIMK DLEGSDIDTR EHDPVGQMVNNPK GSNTIASAAADKIPGLLGVFQK LLQTDDEEEAGLLELLK LVLDAFALPLTNLFK QLSDAISIIGR SANVNEFPVLK TGNIPALVR YGALALQEIFDGIQPK ELTSELKENFIR ITLYGR MYATIYELK MYATIYELKEDK SYPGLTSYLVR TFVPGCQPGEFTLGNIK VPLQQNFQDNQFQGK VVSTNYNQHAMVFFK WYVVGLAGNAILR ADLSGIASGGR LTFQNLMEWTNPR QLPQSTLFR YVEVFFPQFK GYTLVEYETYK MREDYDSVEQDGDEPGPQR LYGDDALDNALQTFIK NSIVNSQPPEK ELAPAVSVLQLFCSSPK QEIFQEQLAAVPEFR SIATLAITTLLK SSPEPVALTESETEYVIR TLEEAVGNIVK EFGADCK YNAQCQETIR ATEEDSQVPSIR ATPYTFPGGTGQIINK GNQLWEYDPVK HYFSLGEIR NFFYIISPGVTK TPTMAGGLFSIDR VDYGDISSR DIPNENEAQFQIR LASQANIAQVLAELK LQSSNIFTVAK MEPLNNLQVAVK NVEGQDMLYQSLK FLEESVSMSPEER SQGQDVTSSVYFMK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

52.7 82.2 47.2 62.9 47.8 46.3 30.8 94.2 32.3 58.8 43.9 40.5 83.9 73.1 37.8 54.7 64.8 79.9 57.1 91.3 58.1 65.1 46.0 51.4 49.0 42.8 60.7 51.5 66.5 32.5 42.7 38.3 65.3 109.0 34.7 36.8 42.4 56.5 41.7 55.5 39.6 63.2 64.6 37.7 57.6 58.9 44.5 46.1 53.5 89.0 75.7

21.4 23.2 22.7 21.8 20.8 21.6 16.9 21.1 13.2 21.4 23.0 18.0 20.7 21.1 19.7 22.4 22.8 22.0 22.3 23.0 22.5 19.1 22.8 22.9 22.3 24.5 22.6 14.9 22.1 21.7 21.4 22.1 11.1 22.6 22.5 16.0 21.0 21.5 22.8 24.1 22.9 21.4 22.8 21.0 22.5 17.6 21.2 22.3 22.3 20.4 20.8

2 2 1 2 2 2 0 2 1 2 2 1 2 8 7 12 6 17 8 33 8 29 1 2 4 2 2 0 2 1 1 2 1 4 1 2 2 3 2 2 2 2 4 2 1 2 1 4 2 5 3

0 0 0 0 0 0 1 0 0 0 0 0 0 5 0 0 0 0 0 2 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,029.53 1,787.85 965.51 1,668.82 1,120.51 1,480.69 2,158.19 1,929.01 1,674.98 1,172.66 1,217.65 940.56 1,762.94 1,478.79 722.42 1,147.57 1,503.74 1,255.67 1,864.93 1,790.88 1,784.88 1,431.81 1,003.52 1,665.81 1,089.61 1,303.67 1,365.66 2,238.92 1,796.91 1,212.62 1,845.98 1,804.92 1,244.78 2,006.99 1,172.65 826.34 1,282.59 1,331.64 1,664.87 1,348.65 1,121.57 1,385.75 1,365.68 1,011.47 1,573.76 1,568.90 1,207.67 1,371.73 1,540.73 1,555.70 1,576.73

Table S1 page 102/159

Putative tropomyosin alpha-3 chain- TPM3L_HUMAN --like protein

26,252

100.00%

4

5

15

Ribosome maturation protein SBDS SBDS_HUMAN SBDS

28,746

100.00%

3

3

3

Cleavage stimulation factor subunit 1 CSTF1_HUMAN CSTF1

48,341

100.00%

3

3

4

VTHETSAHEGQTEAPSIDEK WLPLEANPEVTNQFLK 24.70% AELAESR HIAEEADR IQVLQQQADDAEER IQVLQQQADDAEERAER LKEAETR LMDQNLK MELQEIQLK 12.80% DLDEVLQTHSVFVNVSK GEVQVSDKER SGVEKDLDEVLQTHSVFVNVSK

Leucine-rich repeat flightlessinteracting protein 1

LRRF1_HUMAN LRRFIP1

89,235

100.00%

3

3

11

Heat shock protein HSP 90-alpha

HS90A_HUMAN HSP90AA1

84,645

100.00%

23

29

321

8.58% LGMENDDTAVQYAIGR NLLSLGHNNIVR YTGAGLSGR 4.70% EFTNQEAAEPK IDGATQSSPAEPK SAVEAQNEVTENPK 47.10% ADLINNLGTIAK ALLFVPR APFDLFENR APFDLFENRK DNSTMGYMAAK DQVANSAFVER EDQTEYLEER EGLELPEDEEEK EGLELPEDEEEKK EKYIDQEELNK ELHINLIPNK ELHINLIPNKQDR ELISNSSDALDK ELISNSSDALDKIR EMLQQSK GVVDSEDLPLNISR HFSVEGQLEFR HIYYITGETK HLEINPDHSIIETLR HNDDEQYAWESSAGGSFTVR HSQFIGYPITLFVEK HSQFIGYPITLFVEKER IMKDILEK IRYESLTDPSK KHLEINPDHSIIETLR KHSQFIGYPITLFVEK LGIHEDSQNR LSELLR LVTSPCCIVTSTYGWTANMER NPDDITNEEYGEFYK RAPFDLFENR SLTNDWEDHLAVK TDTGEPMGR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

96.7 72.3 35.7 38.5 108.0 59.9 42.4 43.1 56.2 38.2 35.4 33.0 68.0 36.0 50.3 43.3 45.4 84.8 74.8 45.0 81.0 34.0 73.2 78.7 49.1 58.8 43.1 55.1 34.5 44.6 80.1 99.6 50.8 113.0 64.6 43.0 85.7 133.0 68.5 28.2 36.0 47.5 23.5 29.9 49.0 44.8 94.9 98.2 46.6 83.6 55.4

20.9 20.7 24.2 22.0 22.1 22.0 24.5 23.8 23.9 21.9 24.0 21.0 21.9 19.2 22.2 21.0 21.7 21.3 20.9 18.9 22.4 22.8 16.0 22.9 18.8 20.1 20.8 23.3 20.0 20.2 23.3 22.3 23.4 22.4 23.7 22.1 21.8 17.3 20.8 20.5 21.2 22.3 19.0 18.9 23.1 23.2 20.9 17.2 23.1 21.8 19.8

2 6 1 4 9 1 6 1 5 0 1 0 2 1 1 2 6 3 86 17 16 1 11 32 12 3 2 4 1 5 18 5 6 54 7 11 10 7 23 0 1 2 0 0 6 17 3 26 12 97 10

2 0 0 0 0 3 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 1 0 0 4 0 42 54 9 1 0 0 0 1 9 0 0 0 1 7 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,166.00 1,899.00 775.40 940.45 1,642.80 1,998.98 846.47 877.45 1,131.61 1,929.99 1,146.58 2,430.25 1,752.82 1,349.77 881.45 1,263.59 1,300.64 1,515.73 1,242.71 815.51 1,108.54 1,236.64 1,204.50 1,235.60 1,311.57 1,416.64 1,544.73 1,408.70 1,190.69 1,589.88 1,291.64 1,560.82 879.42 1,513.79 1,348.67 1,224.63 1,786.95 2,255.96 1,778.95 2,064.09 989.57 1,308.68 1,915.04 1,907.04 1,168.57 730.45 2,462.12 1,833.78 1,264.64 1,527.74 963.42

Table S1 page 103/159

Oligoribonuclease, mitochondrial

ORN_HUMAN REXO2

26,816

99.90%

2

2

3

Interleukin-1 receptor-like 1

ILRL1_HUMAN IL1RL1

63,341

100.00%

8

11

118

TLTIVDTGIGMTK TLVSVTK VILHLK VILHLKEDQTEYLEER YESLTDPSK YESLTDPSKLDSGK YIDQEELNK YYTSASGDEMVSLK 10.10% ALDDISESIK QPDELLDSMSDWCK 18.20% DEQGFSLFPVIGAPAQNEIK DEQGFSLFPVIGAPAQNEIKEVEIGK

FLPAAVADSGIYTCIVR IQQEEGQNQSFSNGLACLDMVLR

ITDFGEPR QSWGLENEALIVR SFTVKDEQGFSLFPVIGAPAQNEIK

T-complex protein 1 subunit zeta

TCPZ_HUMAN CCT6A

58,007

100.00%

6

6

19

VFASGQLLK 17.50% ALQFLEEVK DGNVLLHEMQIQHPTASLIAK GIDPFSLDALSK IITEGFEAAK VATAQDDITGDGTTSNVLIIGELLK

Cellular nucleic acid-binding protein CNBP_HUMAN CNBP

19,444

100.00%

4

5

6

Gamma-synuclein

SYUG_HUMAN SNCG

13,312

99.50%

2

3

4

Plastin-3

PLST_HUMAN PLS3

70,796

100.00%

16

20

80

VLAQNSGFDLQETLVK 25.40% CGESGHLAK CGETGHVAINCSK GFQFVSSSLPDICYR TSEVNCYR 13.40% EDLRPSAPQQEGEASK KEDLRPSAPQQEGEASK 38.60% AESMLQQADK ALENDPDCR ANDDIIVNWVNR AYFHLLNQIAPK DGETLEELMK HVIPMNPNTDDLFK IDINMSGFNETDDLKR IKVPVDWSK INNFSADIKDSK KLENCNYAVELGK LSPEELLLR MINLSVPDTIDER NEALAALLR QFVTPADVVSGNPK RYTLNVLEDLGDGQK SGNLTEDDKHNNAK VYALPEDLVEVKPK YAFVNWINK YAVSMAR YPALTKPENQDIDWTLLEGETR YTLNVLEDLGDGQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

109.0 40.7 35.5 69.3 43.0 67.9 60.6 74.2 59.6 43.1 79.3 48.1 115.0 53.7 56.2 98.5 38.1 61.7 45.3 27.8 37.9 46.1 88.9 89.5 32.1 51.8 48.8 44.3 37.3 35.5 63.1 37.8 55.1 43.1 52.5 32.8 86.2 43.3 61.2 63.0 67.1 66.8 79.1 87.7 32.9 48.6 60.2 34.8 31.3 63.3 90.0

22.1 19.6 7.8 22.0 23.0 22.6 23.1 19.8 23.8 19.6 21.7 19.8 21.5 20.8 23.1 21.9 20.6 18.2 21.9 20.5 22.9 21.8 18.6 21.1 18.6 17.6 22.3 17.9 21.5 22.0 22.3 16.5 21.8 21.0 21.2 21.9 21.2 21.3 22.8 22.8 17.1 22.8 18.2 22.6 22.0 20.6 18.7 20.9 20.5 21.8 22.3

57 4 7 7 9 14 21 37 2 1 18 0 6 2 31 26 0 18 4 0 2 4 4 4 1 1 2 1 0 0 3 3 2 0 3 0 2 0 4 2 7 24 16 11 0 1 4 1 1 2 7

0 0 0 102 0 3 0 0 0 0 3 8 3 1 0 0 2 0 0 1 0 0 0 0 0 1 0 0 1 2 0 0 0 4 0 2 4 4 0 0 0 0 0 0 1 2 2 0 0 5 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,365.73 747.46 722.49 2,015.05 1,039.49 1,539.75 1,151.56 1,566.70 1,090.56 1,723.73 2,160.10 2,815.45 1,852.96 2,653.24 934.46 1,514.80 2,722.41 962.57 1,076.60 2,331.21 1,262.66 1,078.58 2,544.34 1,761.94 958.44 1,432.63 1,775.84 1,028.45 1,741.84 1,869.93 1,136.53 1,089.46 1,428.72 1,414.78 1,180.54 1,656.81 1,883.88 1,071.62 1,351.69 1,537.77 1,069.63 1,518.75 970.57 1,458.76 1,720.89 1,542.72 1,599.90 1,154.60 813.39 2,589.28 1,564.79

Table S1 page 104/159

Putative phospholipase B-like 1

PLBL1_HUMAN PLBD1

63,240

100.00%

2

2

3

ATP synthase subunit beta, mitochondrial

ATPB_HUMAN ATP5B

56,543

100.00%

11

12

40

Creatine kinase U-type, mitochondrial

KCRU_HUMAN CKMT1A

47,020

100.00%

5

5

10

Nodal modulator 1

NOMO1_HUMAN NOMO1

134,308

100.00%

5

5

11

Lysosome-associated membrane glycoprotein 1

LAMP1_HUMAN LAMP1

44,865

100.00%

3

3

17

45,963

99.90%

2

2

4

Arrestin domain-containing protein 1 ARRD1_HUMAN ARRDC1 Transforming growth factor beta-2

TGFB2_HUMAN TGFB2

47,731

100.00%

2

2

13

Transformer-2 protein homolog alpha Peptidyl-prolyl cis-trans isomerase FKBP2

TRA2A_HUMAN TRA2A

32,671

99.90%

2

2

8

FKBP2_HUMAN FKBP2

15,632

100.00%

3

4

5

Basement membrane-specific heparan sulfate proteoglycan core protein

PGBM_HUMAN HSPG2

3.98% QVIPETLLSWQR TTGWGILEIR 30.60% AIAELGIYPAVDPLDSTSR FTQAGSEVSALLGR IGLFGGAGVGK IMDPNIVGSEHYDVAR IMNVIGEPIDER IPSAVGYQPTLATDMGTMQER TIAMDGTEGLVR TVLIMELINNVAK VALVYGQMNEPPGAR VLDSGAPIKIPVGPETLGR VVDLLAPYAK 13.70% GTGGVDTAATGGVFDISNLDR HTTDLDASK LGYILTCPSNLGTGLR RGTGGVDTAATGGVFDISNLDR VVVDALSGLK 5.07% DGENYVVLLDSTLPR EQQLAEIEAR IQSTVTQPGGK SSIDSEPALVLGPLK VQVMVPEAETR 8.63% ALQATVGNSYK FFLQGIQLNTILPDAR TVESITDIR 5.08% LGAPLPFR VVYSPGEPLAGTVR 5.80% FAGIDGTSTYTSGDQK IELYQILK 8.16% GFAFVYFER YGPLSGVNVVYDQR 28.90% KLVIPSELGYGER LEDGTEFDSSLPQNQPFVFSLGTGQVIK

468,761

100.00%

75

85

619

LVIPSELGYGER 20.90% AFAHLQVPER AGFFGDAMK AGLSSGFIGCVR AHSSAGQQVAR AMDFNGILTIR ASYAQQPAESR ATATSCRPCPCPYIDASR AVTLECVSAGEPR CAPGYYGNPSQGQPCQR CEQCQPGYYGDAQR CESCAPGYEGNPIQPGGK CKNNVVGR CSATGSPTPTLEWTGGPGGQLPAK

DFISLGLQDGHLVFR EDGRPVPSGTQQR EGGQLPPGHSVQDGVLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

54.4 50.9 73.2 87.2 45.8 42.2 56.2 53.1 60.0 76.2 79.7 62.1 40.6 106.0 37.8 38.5 34.8 65.1 53.8 56.0 30.8 86.9 34.7 41.2 75.9 34.8 42.8 52.2 108.0 43.8 52.2 56.5 36.8 28.1 63.2 42.8 32.8 46.2 45.0 35.9 70.6 54.8 97.2 62.3 49.0 104.0 34.1 82.8 77.6 35.9 30.4

20.9 22.6 21.7 22.1 20.4 21.5 22.5 21.4 22.9 19.4 23.0 14.0 19.3 22.2 20.9 20.8 22.2 20.3 22.3 23.3 23.0 20.6 22.8 22.8 18.0 23.3 19.8 21.1 20.7 14.0 23.2 22.5 20.3 21.1 22.3 21.8 17.2 23.9 21.1 22.6 22.3 19.4 22.7 16.4 11.8 17.2 24.1 21.8 20.9 21.9 23.2

1 2 4 4 6 0 4 2 3 2 4 2 2 2 1 2 0 4 3 2 1 4 1 6 10 1 2 2 7 6 2 6 1 0 2 4 2 2 2 4 61 0 8 1 2 2 1 1 15 3 0

0 0 0 0 0 2 0 0 0 0 0 5 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 4 0 0 0 0 0 2 0 0 0 0 0 0 8 4 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,469.81 1,145.63 1,988.03 1,435.75 975.56 1,831.87 1,401.71 2,298.08 1,278.64 1,473.84 1,617.81 1,919.10 1,088.64 2,022.97 987.47 1,734.92 2,179.07 1,000.60 1,690.87 1,186.61 1,115.61 1,525.85 1,274.64 1,151.61 1,846.02 1,033.55 870.52 1,444.78 1,647.75 1,019.61 1,135.56 1,566.79 1,460.81 3,053.51 1,332.72 1,167.63 943.43 1,223.62 1,111.56 1,266.65 1,207.57 2,082.92 1,388.68 1,939.82 1,731.69 1,920.82 946.49 2,370.14 1,716.91 1,426.70 1,745.89

Table S1 page 105/159

EGGSLPPQAR EQAWQRPDGQPATR ESDQGAYTCEAMNAR ESIQASR EVSEAVVDTLESEYLK FDAGSGMATIR FSSGITGCVK FTVTQR GHTPTQPGALNQR GMVFGIPDGVLELVPQR GPSCQDCDTGYTR GSIQVDGEELVSGR GSVYIGGAPDVATLTGGR HCTSSSWSR HQIVGSR HQTHGSLLR IAHVELADAGQYR IESSSPTVVEGQTLDLNCVVAR IQVVVLSASDASPPPVK ITFRPDSADGMLLYNGQK LCNECADGSFHLSTR LDGSLPPDSR LEGDTLIIPR LGTVPQFPR LLQVTPADSGEYVCR LLSGPYFWSLPSR LPAVEPTDQAQYLCR LRSPVISIDPPSSTVQQGQDASFK

LSGSHSQGVAYPVR LVSEDPINDGEWHR LYIFQASPADAGQYVCR LYQASPADSGEYVCR NLVLHSARPGAPPPQPLDLQHR NPDGCLK RGGSLPAR RGSIQVDGEELVSGR RPDGQPATR RVPGSPTNLANR SAEPLALGR SIEYSPQLEDAGSR SIVPQGGSHSLR SLPEVPETIELEVR SPAYTLVWTR SPGPNVAVNAK SPLPWQHR SPVISIDPPSSTVQQGQDASFK TQVHAGR TSTASGLLLWQGVEVGEAGQGK

VAEGQTLDLK VDSYGGSLR VGSSLPGR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

41.3 42.2 74.1 37.6 134.0 85.7 31.7 38.1 49.5 53.5 80.5 70.8 119.0 30.2 30.5 37.7 65.1 108.0 51.7 33.3 31.6 45.2 78.9 53.6 77.3 50.5 94.2 73.1 45.3 71.3 91.1 97.3 36.0 32.4 36.5 59.7 36.8 36.5 34.3 111.0 29.1 90.9 83.2 78.1 35.7 121.0 35.3 111.0 74.3 48.1 58.7

22.0 22.6 10.8 24.7 22.5 21.3 21.6 21.1 23.1 20.7 12.6 22.5 21.9 15.6 19.9 23.6 22.3 21.2 16.4 22.1 18.5 22.1 20.1 22.3 21.6 21.5 22.3 20.6 22.2 21.9 21.9 19.9 18.0 17.8 20.9 22.6 21.6 20.4 20.4 21.7 21.4 20.7 22.1 21.2 23.9 22.8 20.0 21.2 23.4 22.1 22.7

12 3 4 6 25 29 1 3 4 4 2 32 9 1 1 0 5 4 5 0 0 8 26 12 6 6 5 0 5 7 8 9 0 2 1 4 2 2 3 16 0 9 10 22 1 9 1 4 9 8 20

0 0 0 0 0 0 0 0 18 0 0 0 0 0 0 12 4 0 0 1 1 0 0 0 0 0 0 5 2 3 0 0 2 0 0 0 0 0 0 0 2 0 0 0 0 2 0 2 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,011.52 1,639.79 1,702.68 790.41 1,810.90 1,141.53 1,055.52 751.41 1,376.70 1,842.98 1,516.58 1,445.72 1,690.88 1,107.46 796.44 1,048.57 1,442.74 2,374.19 1,706.97 2,042.00 1,766.76 1,056.53 1,126.65 1,014.57 1,707.84 1,522.81 1,760.86 2,557.33 1,457.75 1,666.78 1,958.94 1,715.77 2,413.32 803.37 813.47 1,601.82 997.52 1,281.70 913.51 1,551.73 1,237.67 1,610.86 1,193.63 1,053.57 1,020.54 2,288.14 768.41 2,188.13 1,073.58 953.47 772.43

Table S1 page 106/159

Plasma alpha-L-fucosidase

FUCO2_HUMAN FUCA2

54,050

100.00%

3

3

18

Beta-1,4-galactosyltransferase 1

B4GT1_HUMAN B4GALT1

43,903

100.00%

3

3

19

VISSGSVASYVTSPQGFQFR VPGSPTNLANR VQVSPER VTSYGGELR VTVTSEGGR VVPYFTQTPYSFLPLPTIK YELGSGLAVLR YQLGSGEAR 8.35% FDPTWESLDAR FFNANQWADIFQASGAK YEDFGPLFTAK 14.30% ETMLSDGLNSLTYQVLDVQR LPQLVGVSTPLQGGSNSAAAIGQSSGELR

Protein canopy homolog 2

CNPY2_HUMAN CNPY2

20,635

100.00%

3

3

7

Quinone oxidoreductase PIG3

QORX_HUMAN TP53I3

35,519

100.00%

3

3

4

T-complex protein 1 subunit delta

TCPD_HUMAN CCT4

57,908

100.00%

11

12

23

EH domain-containing protein 2

EHD2_HUMAN EHD2

61,145

100.00%

2

2

4

Secernin-1

SCRN1_HUMAN SCRN1

46,364

100.00%

3

4

9

Isopentenyl-diphosphate Deltaisomerase 1

IDI1_HUMAN IDI1

26,302

100.00%

4

4

12

Neutral alpha-glucosidase AB

GANAB_HUMAN GANAB

106,858

100.00%

23

28

198

VAIIIPFR 25.80% ALVDELEWEIAQVDPK INPDGSQSVVEVPYAR SEAHLTELLEEICDR 11.40% EVAKPSPGEGEVLLK GSLITSLLR MAGAIPLVTAGSQK 27.60% AFADAMEVIPSTLAENAGLNPISTVTELR ALIAGGGAPEIELALR AVADAIR DALSDLALHFLNK IDDVVNTR IGLIQFCLSAPK LVIEEAER TAGINVR TDMDNQIVVSDYAQMDR VIDPATATSVDLR VVSQYSSLLSPMSVNAVMK 4.24% LEGHGLPANLPR LFELEEQDLFR 9.66% AIIESDQEQGR EPAAEIEALLGMDLVR SIFKPFIFVDDVK 23.30% AELGIPLEEVPPEEINYLTR AFSVFLFNTENK IIAATFLFK NVTLNPDPNEIK 26.80% AEKDEPGAWEETFK DENSVELTMAEGPYK DPAEGDGAQPEETPR DPAEGDGAQPEETPRDGDKPEETQGK

FRIDELEPR GLLEFEHQR KLVAIVDPHIK LDLLEDR LKVTEGGEPYR LSFQHDPETSVLVLR LVAIVDPHIK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

105.0 35.8 36.5 43.7 59.1 40.1 96.4 63.7 70.1 102.0 56.2 111.0 37.1 35.5 56.9 66.3 28.7 45.9 44.6 30.1 26.3 64.2 32.9 77.7 36.8 35.8 32.2 36.5 90.8 74.7 63.6 33.8 38.3 55.7 69.1 43.4 59.7 64.8 43.7 52.7 66.5 115.0 109.0 19.8 38.5 59.9 54.8 44.5 49.0 58.0 60.2

22.1 22.9 20.5 21.8 24.2 17.3 20.8 22.8 21.0 21.7 22.1 21.7 19.7 15.8 21.3 21.7 21.8 19.1 17.3 21.5 20.6 17.6 24.0 21.9 23.7 20.8 21.2 24.0 17.9 22.2 22.1 21.9 22.9 22.5 21.5 19.7 20.8 22.3 14.5 22.0 21.8 19.7 19.6 18.0 23.5 21.9 8.5 22.3 22.9 20.7 14.6

13 1 2 6 15 1 25 8 5 5 8 11 0 5 3 2 0 1 2 1 0 3 1 2 2 2 1 2 2 4 2 0 2 4 3 1 4 2 2 4 3 7 6 0 1 6 0 2 2 0 5

0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 2 0 0 0 1 0 0 1 0 0 0 0 0 0 0 2 0 0 1 0 0 0 0 0 3 0 0 0 1 0 7 0 2 26 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,117.07 1,125.60 814.44 981.50 905.47 2,211.21 1,177.66 980.48 1,336.62 1,914.91 1,287.63 2,298.13 2,794.47 928.60 1,854.95 1,730.87 1,814.86 1,552.86 959.59 1,343.74 3,046.54 1,550.89 715.41 1,456.78 931.49 1,346.75 958.52 730.42 2,032.86 1,357.73 2,072.04 1,273.70 1,438.72 1,245.61 1,742.90 1,554.86 2,282.19 1,416.72 1,023.62 1,353.70 1,636.75 1,698.75 1,568.68 2,753.21 1,174.62 1,128.58 1,232.77 873.47 1,248.66 1,740.93 1,104.68

Table S1 page 107/159

MMDYLQGSGETPQTDVR NPEPELLVR QYASLTGTQALPPLFSLGYHQSR

Serine/threonine-protein phosphatase PP2AB_HUMAN PPP2CB 2A catalytic subunit beta isoform

35,557

100.00%

3

3

11

T-complex protein 1 subunit gamma TCPG_HUMAN CCT3

60,517

100.00%

9

9

12

34,796

100.00%

17

20

220

Insulin-like growth factor-binding protein 2

IBP2_HUMAN IGFBP2

REPWLLPSQHNDIIR SGGMERPFVLAR SIRPGLSPYR VPDVLVADPPIAR VSQGSKDPAEGDGAQPEETPR VTEGGEPYR VVIIGAGKPAAVVLQTK WYQMGAYQPFFR YRVPDVLVADPPIAR 11.00% ESNVQEVR SPDTNYLFMGDYVDR YSFLQFDPAPR 17.10% AMTGVEQWPYR AVAQALEVIPR ELGIWEPLAVK GISDLAQHYLMR KVQSGNINAAK TAVETAVLLLR TLIQNCGASTIR VQSGNINAAK WSSLACNIALDAVK 69.20% CPPCTPER CYPHPGSELPLQALVMGEGTCEK DAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGR

EKVTEQHR GDPECHLFYNEQQEAR GECWCVNPNTGK GPLEHLYSLHIPNCDK HGLYNLK HHLGLEEPK HHLGLEEPKK LAACGPPPVAPPAAVAAVAGGAR

Matrix metalloproteinase-9

MMP9_HUMAN MMP9

78,442

100.00%

11

11

45

LEGEACGVYTPR LIQGAPTIR MPCAELVR MSLNGQR SGMKELAVFR TPCQQELDQVLER 19.70% AFALWSAVTPLTFTR AVIDDAFAR FQTFEGDLK FTEGPPLHKDDVNGIR GSRPQGPFLIADKWPALPR LFGFCPTR LGLGADVAQVTGALR QLAEEYLYR QLSLPETGELDSATLK QSTLVLFPGDLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

110.0 46.4 69.6 38.7 39.8 35.9 41.8 93.9 42.2 66.8 38.7 43.3 44.6 69.6 64.7 38.8 72.6 40.5 41.1 49.2 84.3 45.9 34.3 71.5 34.4 58.7 22.5 56.3 67.0 71.0 30.8 39.8 51.1 30.3 107.0 85.4 43.7 50.5 36.9 44.2 108.0 65.4 42.8 31.6 32.9 44.3 42.5 110.0 42.3 65.6 74.0

17.3 20.7 20.2 20.5 23.0 21.7 17.0 20.8 21.9 3.0 19.8 17.4 22.5 20.2 21.8 21.3 16.3 19.1 22.9 21.6 15.8 23.4 23.0 22.8 16.8 20.3 14.1 22.0 15.9 15.3 22.1 22.7 22.2 23.0 19.3 21.6 15.7 21.6 22.8 23.2 21.4 20.6 23.5 22.1 22.5 17.5 21.6 18.9 20.8 21.9 21.0

18 6 0 0 0 1 2 6 13 5 1 0 3 4 4 1 2 1 1 1 2 2 1 1 1 0 0 6 2 8 0 20 1 0 41 21 31 8 4 0 12 2 2 1 0 0 2 8 2 4 6

0 0 14 4 4 0 0 36 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 4 0 1 0 48 1 4 0 0 0 0 4 0 0 0 0 2 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,959.84 1,066.59 2,535.30 1,874.00 1,335.68 1,145.64 1,361.78 2,154.99 1,007.48 1,664.05 1,609.73 1,680.94 960.48 1,792.79 1,340.66 1,353.63 1,166.69 1,254.71 1,419.71 1,129.63 1,185.72 1,333.69 1,001.54 1,547.79 1,016.43 2,589.18 4,318.81 1,026.53 1,992.85 1,421.59 1,892.93 844.47 1,059.56 1,187.65 2,041.10 1,351.63 968.59 975.48 805.40 1,153.60 1,615.78 1,680.91 977.51 1,084.53 1,794.91 2,106.16 997.49 1,440.82 1,184.60 1,701.89 1,345.75

Table S1 page 108/159

LDLR chaperone MESD

MESD_HUMAN MESDC2

Glutathione reductase, mitochondrial GSHR_HUMAN GSR

26,060

100.00%

5

5

8

56,239

100.00%

8

9

51

Isocitrate dehydrogenase [NADP] cytoplasmic

IDHC_HUMAN IDH1

46,643

100.00%

18

20

114

Quinone oxidoreductase

QOR_HUMAN CRYZ

35,189

100.00%

6

6

20

SLGPALLLLQK 27.80% DYNDADMAR IDPSKPESILK LLEQWEKDDDIEEGDLPEHK RPSAPVDFSK TLMMFVTVSGSPTEK 23.00% ADFDNTVAIHPTSSEELVTLR ALLTPVAIAAGR GHAAFTSDPKPTIEVSGK LGGTCVNVGCVPK LGIQTDDKGHIIVDEFQNTNVK LNAIYQNNLTK RAAELGAR TYSTSFTPMYHAVTK 50.50% ATDFVVPGPGK DAAEAIKK DATNDQVTK FKDIFQEIYDK GQETSTNPIASIFAWTR GWPLYLSTK IIWELIK ISGGSVVEMQGDEMTR KISGGSVVEMQGDEMTR LIDDMVAQAMK LVSGWVKPIIIGR NILGGTVFR SDYLNTFEFMDK SEGGFIWACK SIEDFAHSSFQMALSK TVEAEAAHGTVTR VEITYTPSDGTQK VTYLVHNFEEGGGVAMGMYNQDK

27.40% ILGTAGTEEGQK KPLLPYTPGSDVAGVIEAVGDNASAFK

Desmoplakin

DESP_HUMAN DSP

331,763

100.00%

28

29

115

QGAAIGIPYFTAYR SDIAVPIPK VAEAHENIIHGSGATGK VFEFGGPEVLK 11.60% AELIVQPELK AESGPDLR AFIGFEGVK ALLQAILQTEDMLK ANSSATETINK ATGSEVSQR FGDSNTVMR FLEFQYLTGGLVDPEVHGR GFFDPNTEENLTYLQLK GIVDSITGQR GYFNEELSEILSDPSDDTK IEVLEEELR ISITEGIER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

80.3 42.3 43.6 36.7 44.7 38.5 66.1 74.6 30.8 53.0 43.0 55.9 56.2 58.8 64.4 37.5 40.0 52.0 97.2 47.1 30.7 98.6 38.4 57.0 58.9 54.8 81.6 48.1 40.6 76.1 63.4 63.1 53.0 33.1 52.7 41.5 79.1 47.1 52.9 35.3 36.0 72.7 51.2 44.0 49.8 47.8 76.7 45.6 67.5 51.7 33.5

11.5 13.2 19.1 21.8 23.5 21.6 21.6 14.0 21.4 22.8 20.6 21.8 21.5 21.8 23.2 23.4 21.8 22.8 23.0 22.3 20.2 18.8 21.3 22.5 12.3 20.8 17.2 20.5 21.6 22.7 23.0 18.6 23.5 19.5 21.0 14.8 22.3 22.9 16.8 19.4 21.5 19.9 23.4 23.6 18.8 21.6 22.5 22.7 20.3 23.7 23.0

12 1 2 0 2 1 1 20 0 2 0 6 3 4 5 2 1 6 27 4 2 6 0 5 2 5 10 2 2 10 8 0 4 0 4 4 2 4 4 1 2 12 2 1 4 0 8 4 2 4 1

0 0 0 2 0 0 9 0 1 0 5 0 0 0 0 0 0 6 0 0 0 0 2 0 3 0 0 0 0 0 0 6 0 2 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,152.74 1,086.42 1,226.70 2,438.14 1,103.59 1,659.80 2,315.15 1,152.71 1,841.94 1,360.67 2,484.27 1,291.70 843.48 1,733.82 1,087.58 845.47 991.47 1,445.73 1,878.94 1,064.58 914.57 1,727.76 1,855.85 1,266.61 1,437.89 976.56 1,525.65 1,154.53 1,813.84 1,341.68 1,438.71 2,591.15 1,203.62 2,716.42 1,527.80 939.55 1,690.85 1,221.65 1,139.67 844.42 967.53 1,586.88 1,135.56 934.46 1,042.46 2,177.10 2,028.99 1,045.56 2,158.97 1,129.61 1,017.56

Table S1 page 109/159

Protein RCC2

RCC2_HUMAN RCC2

56,067

100.00%

8

11

42

Vinculin

VINC_HUMAN VCL

123,783

100.00%

45

48

212

ITNLTQQLEQASIVK LSLQDAVSQGVIDQDMATR NQCTQVVQER QAELDGK QLQNIIQATSR RVEEDIQQQK SAIYQLEEEYENLLK SGSLSLTQFADMISLK SMVEDITGLR STLEAETR SVQNDSQAIAEVLNQLK TLELQGLINDLQR VTQLTDR YEVTSGGGGTSR YGDGIQLTR 14.20% AGGAAVVITEPEHTK AGGAAVVITEPEHTKER DGQILPVPNVVVR LFDFPGR LGHAEQKDEMVPR RVEAPR VFSWGFGGYGR VKLEGSK 47.90% AAAVGTANK AGEVINQPMMMAAR AIPDLTAPVAAVQAAVSNLVR ALASIDSK ALASQLQDSLK AQQVSQGLDVLTAK AVAGNISDPGLQK AVANSRPAK DPSASPGDAGEQAIR EAEAASIK EAFQPQEPDFPPPPPDLEQLR ELLPVLISAMK ELTPQVVSAAR ETVQTTEDQILK ETVQTTEDQILKR EVENSEDPK EVENSEDPKFR GEGESPQAR GQGSSPVAMQK GVGQAAIR GWLRDPSASPGDAGEQAIR IPTISTQLK KIDAAQNWLADPNGGPEGEEQIR

LANVMMGPYR LLAVAATAPPDAPNREEVFDER LVQAAQMLQSDPYSVPAR MALLMAEMSR MLGQMTDQVADLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

72.9 78.6 43.1 30.4 63.8 34.8 69.2 53.3 34.2 36.1 99.2 71.1 30.2 59.5 46.2 57.1 50.7 60.8 37.0 42.9 38.9 38.9 41.0 46.4 56.1 103.0 31.7 66.3 102.0 76.8 61.8 84.5 46.5 79.6 59.6 40.6 55.6 67.7 32.5 43.2 47.5 55.4 55.5 36.3 42.5 69.9 62.5 47.1 88.1 76.8 88.2

17.3 22.4 21.7 22.6 22.2 22.7 21.8 22.5 22.9 24.1 21.0 20.1 24.9 21.1 22.2 22.1 21.2 15.9 21.7 22.6 19.6 21.7 20.5 25.2 20.5 13.4 25.0 22.9 21.6 21.1 20.1 20.9 24.2 21.6 18.7 21.6 23.1 22.3 18.0 21.8 18.6 22.8 18.9 22.2 19.3 21.4 21.3 21.2 21.7 22.5 21.8

1 1 15 1 13 2 6 2 3 4 7 3 1 5 2 6 0 7 4 1 3 2 3 1 10 8 2 12 11 10 2 9 1 4 12 2 2 2 1 2 1 4 4 1 2 0 2 0 4 4 5

0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 5 5 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 0 10 1 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,685.94 2,063.01 1,261.60 760.38 1,271.71 1,272.66 1,841.92 1,713.87 1,136.56 906.45 1,856.97 1,512.84 832.45 1,170.54 1,022.53 1,479.78 1,764.92 1,405.82 851.44 1,525.74 727.42 1,232.59 760.46 802.44 1,566.71 2,076.18 804.45 1,173.65 1,457.80 1,269.68 913.52 1,470.68 818.43 2,447.19 1,213.72 1,170.65 1,404.72 1,560.82 1,046.46 1,349.63 930.43 1,089.54 771.45 1,982.97 1,000.60 2,508.21 1,183.56 2,381.21 1,990.01 1,152.56 1,509.70

Table S1 page 110/159

MQEAMTQEVSDVFSDTTTPIK MSAEINEIIR MTGLVDEAIDTK NPGNQAAYEHFETMK NQGIEEALK NQGIEEALKNR QVATALQNLQTK SFLDSGYR SLGEISALTSK STVEGIQASVK TNISDEESEQATEMLVHNAQNLMQSVK

Semaphorin-3A

SEM3A_HUMAN SEMA3A

88,873

100.00%

3

3

6

Heat shock 70 kDa protein 1A/1B

HSP71_HUMAN HSPA1A

70,036

100.00%

29

40

520

TNLLQVCER VAMANIQPQMLVAGATSIAR VDQLTAQLADLAAR VLQLTSWDEDAWASK VMLVNSMNTVK WIDNPTVDDR 5.58% DGPNYQWVPYQGR DLPDDVITFAR QQQLYIGSTAGVAQLPLHR 54.40% AEDEVQR AFYPEEISSMVLTK AQIHDLVLVGGSTR ARFEELCSDLFR ATAGDTHLGGEDFDNR CQEVISWLDANTLAEKDEFEHK DAGVIAGLNVLR ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK

FEELCSDLFR FGDPVVQSDMK HWPFQVINDGDKPK IINEPTAAAIAYGLDR ITITNDKGR KFGDPVVQSDMK LDKAQIHDLVLVGGSTR LLQDFFNGR LSKEEIER LVNHFVEEFK LVNHFVEEFKR MVQEAEK MVQEAEKYK NALESYAFNMK NQVALNPQNTVFDAK NQVALNPQNTVFDAKR NSTIPTK QTQIFTTYSDNQPGVLIQVYEGER

SAVEDEGLK SAVEDEGLKGK SINPDEAVAYGAAVQAAILMGDK

STLEPVEK TTPSYVAFTDTER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

133.0 53.6 73.7 59.5 37.8 27.5 81.0 39.7 63.7 78.4 77.7 46.5 155.0 46.4 73.7 51.2 51.0 71.6 63.8 28.8 32.6 93.3 92.0 42.6 80.2 18.5 93.0 92.6 49.7 73.9 50.8 122.0 64.4 44.4 21.4 57.6 55.0 41.3 42.2 49.8 32.2 82.7 108.0 64.5 33.7 46.3 39.1 41.2 135.0 36.5 106.0

20.0 24.0 23.2 21.4 21.2 21.1 21.5 19.5 22.4 22.5 17.8 23.8 19.8 21.2 22.7 22.7 20.3 20.8 23.2 19.1 19.3 22.3 19.9 21.5 18.3 21.0 18.3 20.1 20.0 21.4 22.5 21.0 22.3 22.8 17.6 22.5 22.9 23.1 22.6 23.2 23.3 20.3 22.0 21.8 25.0 21.1 22.6 23.9 21.3 22.2 21.6

4 4 6 1 3 0 11 3 6 2 0 2 5 2 6 5 2 2 3 0 1 35 25 2 16 0 46 0 7 10 1 62 20 4 0 21 12 6 2 3 3 14 37 2 4 2 2 1 17 1 97

0 0 0 0 0 1 0 0 0 0 11 0 6 0 0 0 0 0 0 1 0 0 3 1 24 0 0 7 0 0 58 19 0 0 0 0 0 5 10 0 0 0 0 1 0 3 0 0 3 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,358.08 1,191.60 1,292.64 1,736.77 1,001.53 1,271.67 1,314.74 944.45 1,105.61 1,118.61 3,078.40 1,132.58 2,058.08 1,484.81 1,748.85 1,235.65 1,230.58 1,579.73 1,261.64 2,080.13 846.40 1,630.80 1,465.81 1,542.74 1,675.73 2,662.25 1,197.70 3,055.50 1,315.60 1,238.57 1,680.85 1,687.90 1,017.57 1,350.67 1,822.02 1,109.57 1,003.54 1,261.66 1,417.76 834.40 1,125.56 1,287.60 1,658.85 1,814.95 760.42 2,786.36 947.47 1,132.59 2,320.15 902.48 1,487.70

Table S1 page 111/159

SH3 domain-binding glutamic acid- SH3L3_HUMAN SH3BGRL3 rich-like protein 3

10,420

100.00%

4

5

31

39.80%

VEIIANDQGNR VQVSYK YKAEDEVQR IQYQLVDISQDNALR IQYQLVDISQDNALRDEMR SQQSEVTR VYSTSVTGSR DAEEAISQTIDTIVDMIK GDEGPPGSEGAR GDPGEAGPQGDQGR GDPGFEGER GLEQLLVGGSHLK IALVITDGR LKPYGALVDK LLLFSDGNSQGATPAAIEK NVQELK TAEYDVAYGESHLFR TDPAHDVR VAVVQYSGTGQQRPER VFSVAITPDHLEPR VPSYQALLR LDFLIPLSK NTPSPFIETFTEDDEASR VVINVPIFK ILELDQFK IMATPEQVGK NIPPYFVALVPQEEELDDQK NIYVLQELDNPGAK SDSFENPVLQQHFR TFNTSTGGLLLPSDTKR

Collagen alpha-1(VI) chain

CO6A1_HUMAN COL6A1

108,513

100.00%

14

17

66

16.70%

Glutamate--cysteine ligase catalytic subunit

GSH1_HUMAN GCLC

72,750

100.00%

3

3

4

5.65%

X-ray repair cross-complementing protein 6

XRCC6_HUMAN XRCC6

69,828

100.00%

6

6

11

13.60%

Calpain small subunit 1

CPNS1_HUMAN CAPNS1

28,299

100.00%

4

5

9

Xaa-Pro aminopeptidase 1

XPP1_HUMAN XPNPEP1

69,901

100.00%

2

2

4

Proteasome subunit beta type-3

PSB3_HUMAN PSMB3

22,932

100.00%

7

10

46

Laminin subunit gamma-2

LAMC2_HUMAN LAMC2

130,958

100.00%

23

24

286

23.10% LFAQLAGDDMEVSATELMNILNK LGFEEFK SMVAVMDSDTTGK YSDESGNMDFDNFISCLVR 5.14% GSLTFEPLTLVPIQTK QEALEWLIR VTSELLR 47.80% DAVSGMGVIVHIIEK FGIQAQMVTTDFQK FGPYYTEPVIAGLDPK LNLYELK LYIGLAGLATDVQTVAQR NCVAIAADRR QIKPYTLMSMVANLLYEK 24.60% ADSLSSLVTR AGYFGDPLAPNPADK ALGSAAADAQR ALHEGVGSGSGSPDGAVVQGLVEK

AQGGDGVVPDTELEGR CLNCNDNTDGIHCEK CVCKPAVTGER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

80.0 30.9 50.8 104.0 58.8 45.0 76.8 67.3 68.0 65.3 30.8 46.0 47.8 30.4 88.5 30.1 65.2 32.2 48.9 47.8 54.8 35.9 109.0 56.4 33.2 37.6 34.0 90.9 34.0 58.9 140.0 42.9 47.7 107.0 45.3 43.1 33.9 64.8 87.6 71.2 42.7 102.0 41.6 42.5 63.5 72.7 89.0 73.5 81.4 54.1 36.6

22.6 21.0 23.2 21.4 22.4 23.6 21.7 22.0 21.6 18.6 20.0 18.1 20.0 18.4 22.7 22.9 20.8 21.8 21.8 21.1 21.9 16.8 19.0 14.6 20.3 24.4 22.3 22.1 22.2 21.2 21.0 20.5 16.9 15.2 17.9 21.8 22.3 22.4 22.5 21.5 19.6 16.2 23.2 20.9 23.6 22.5 22.8 21.7 22.0 11.8 22.5

56 1 28 2 4 7 10 2 3 6 1 2 2 0 12 2 2 2 3 3 12 1 2 1 1 2 2 2 0 1 2 1 1 3 2 2 1 2 9 9 6 12 1 0 11 14 63 0 18 1 0

0 0 25 0 8 0 0 0 0 0 0 3 0 1 0 0 3 0 7 0 0 0 0 0 0 0 0 0 3 0 2 0 0 0 0 0 0 0 0 1 0 4 1 1 0 0 0 6 0 0 7

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,228.63 723.40 1,137.55 1,775.93 2,307.14 934.46 1,056.53 2,007.98 1,128.49 1,340.58 963.42 1,350.77 957.57 1,103.65 1,932.01 730.41 1,757.81 910.44 1,774.92 1,580.84 1,046.60 1,045.63 2,055.91 1,028.65 1,005.56 1,089.56 2,344.17 1,573.82 1,703.81 1,807.96 2,523.25 869.44 1,373.59 2,268.95 1,743.99 1,157.63 817.48 1,583.85 1,629.79 1,766.90 892.51 1,889.05 1,145.58 2,174.12 1,048.56 1,532.74 1,030.53 2,250.14 1,599.76 1,849.73 1,276.61

Table S1 page 112/159

Spliceosome RNA helicase BAT1

UAP56_HUMAN BAT1

48,974

100.00%

9

9

33

22.90%

High mobility group protein HMGI/HMG-Y 3-ketoacyl-CoA thiolase, mitochondrial Tissue factor pathway inhibitor

HMGA1_HUMAN HMGA1

11,658

100.00%

2

2

4

22.40%

THIM_HUMAN ACAA2

41,906

100.00%

2

2

3

7.81%

TFPI1_HUMAN TFPI

34,998

100.00%

2

2

5

5.59%

DNA damage-binding protein 2

DDB2_HUMAN DDB2

47,847

100.00%

2

2

3

4.22%

Guanine nucleotide-binding protein subunit beta-2-like 1

GBLP_HUMAN GNB2L1

35,059

100.00%

10

11

40

34.70%

Lactotransferrin

TRFL_HUMAN LTF

78,164

100.00%

2

2

13

2.96%

Galectin-3-binding protein

LG3BP_HUMAN LGALS3BP

65,314

100.00%

24

32

2361

47.40%

EATQAEIEADR EFDLQVDNR ELEFDTNMDAVQMVITEAQK EVEGELER HPSAHDVILEGAGLR HQDVFSSAQR IQMDQFMQQLQR ITSTFHQDVDGWK LAESHVESASNMEQLTR LDPVYFVAPAK MQQAEQALQDILR NLGNWKEEAQQLLQNGK QCIFDR SLAQEATR SSAEYSVHK VSDASDKTQQAER DFLLKPELLR DVQEIFR ELAFQISK FMQDPMEIFVDDETK GLAITFVSDENDAK ILVATNLFGR LTLHGLQQYYVK QVMMFSATLSK VAVFFGGLSIK KQPPVSPGTALVGSQK SSQPLASK AANDAGYFNDEMAPIEVK DFTATDLSEFAAK FFFNIFTR FYYNSVIGK ASFLYSLPHR YNLIVVGR DETNYGIPQR DGQAMLWDLNEGK DVLSVAFSSDNR FSPNSSNPIIVSCGWDK IIVDELKQEVISTSSK LTRDETNYGIPQR LWDLTTGTTTR LWNTLGVCK QIVSGSR YWLCAATGPSIK CGLVPVLAENYK YYGYTGAFR AAFGQGSGPIMLDEVQCTGTEASLADCK

ASHEEVEGLVEK AVDTWSWGER ELSEALGQIFDSQR GLNLTEDTYKPR GQWGTVCDNLWDLTDASVVCR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

62.2 55.6 65.9 40.5 51.3 66.0 83.1 73.1 84.9 71.5 99.2 39.2 31.8 67.2 49.4 78.8 32.5 34.4 37.0 92.6 45.1 79.9 26.4 49.4 42.5 57.4 51.6 78.8 40.6 39.7 38.2 29.1 64.3 52.6 92.9 79.2 49.3 118.0 46.6 55.0 51.4 38.3 44.1 63.3 42.4 49.5 65.9 81.0 125.0 55.4 122.0

20.6 22.2 19.5 21.6 21.3 21.6 22.6 22.6 22.3 21.2 23.0 21.0 22.1 24.5 21.9 21.7 16.1 24.2 20.9 18.3 22.8 17.7 20.0 21.6 16.5 17.8 24.1 19.0 21.4 24.0 24.0 23.3 19.6 22.2 20.8 22.1 20.7 18.1 22.7 22.7 24.2 24.2 22.3 22.2 21.7 19.3 22.9 19.6 22.8 22.9 19.7

3 5 1 2 0 21 28 4 7 13 16 0 2 10 3 4 1 3 2 5 2 10 0 4 5 2 2 2 1 2 3 0 2 5 6 6 2 6 2 6 2 1 2 6 7 0 93 353 314 2 8

0 0 0 0 25 0 0 0 18 0 0 4 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 0 0 0 0 0 0 0 7 78 0 37 3 2

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,232.58 1,135.54 2,344.07 960.46 1,571.83 1,174.56 1,565.76 1,533.73 1,901.90 1,219.67 1,559.79 1,970.01 838.39 875.46 1,007.48 1,434.68 1,243.74 906.47 935.52 1,844.81 1,479.73 1,103.66 1,462.81 1,258.62 1,137.67 1,593.90 817.44 1,970.88 1,415.67 1,091.57 1,090.56 1,190.63 933.55 1,192.56 1,492.67 1,309.64 1,907.90 1,789.00 1,562.79 1,264.65 1,090.57 746.42 1,366.68 1,362.71 1,097.51 2,913.31 1,326.65 1,206.55 1,592.79 1,406.73 2,452.10

Table S1 page 113/159

Glutamate dehydrogenase 1, mitochondrial

DHE3_HUMAN GLUD1

61,382

100.00%

14

18

51

30.10%

Pre-mRNA-processing factor 19

PRP19_HUMAN PRPF19

55,163

100.00%

4

4

7

12.30%

Splicing factor U2AF 65 kDa subunit Heterogeneous nuclear ribonucleoprotein R

U2AF2_HUMAN U2AF2

53,483

100.00%

2

2

12

5.47%

HNRPR_HUMAN HNRNPR

70,926

100.00%

3

3

19

11.20%

PSB4_HUMAN PSMB4

29,187

100.00%

8

9

54

48.50%

Proteasome subunit beta type-4

IDITLSSVK IYTSPTWSAFVTDSSWSAR KSQLVYQSR KTLQALEFHTVPFQLLAR LADGGATNQGR LASAYGAR RIDITLSSVK SDLAVPSELALLK SLGWLK SQLVYQSR STHTLDLSR STSSFPCPAGHFNGFR TIAYENK TLQALEFHTVPFQLLAR TVIRPFYLTNSSGVD VEIFYR YSSDYFQAPSDYR YYPYQSFQTPQHPSFLFQDK ALASLMTYK DDGSWEVIEGYR DIVHSGLAYTMER DSNYHLLMSVQESLER GASIVEDK GASIVEDKLVEDLR GFIGPGIDVPAPDMSTGER HGGTIPIVPTAEFQDR IIAEGANGPTTPEADKIFLER LQHGSILGFPK MVEGFFDR TAAYVNAIEK YNLGLDLR YSTDVSVDEVK IWSVPNASCVQVVR SSEQILATLK TVPEELVKPEELSK YIAENGTDPINNQPLSEEQLIDIK ELLTSFGPLK LFIGGLPNYLNDDQVK AGPIWDLR DLYEDELVPLFEK EAAQEAVK NLATTVTEEILEK TGYTLDVTTGQR VTEGLVDVILYHQPDDK AIHSWLTR FEGGVVIAADMLGSYGSLAR FQIATVTEK GVEIEGPLSTETNWDIAHMISGFE

QPVLSQTEAR QVLGQMVIDEELLGDGHSYSPR

TQNPMVTGTSVLGVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

65.7 145.0 57.8 33.3 95.2 61.8 51.0 90.9 45.3 58.7 43.9 48.6 42.7 87.8 51.7 35.5 105.0 58.5 45.8 79.8 57.7 54.1 44.4 71.7 68.8 59.7 93.0 34.7 53.6 44.2 65.0 77.3 48.4 47.0 56.4 46.0 50.6 53.5 39.9 43.1 37.7 81.0 43.9 34.8 40.8 83.1 45.8 71.0 57.0 94.5 89.8

19.2 21.4 20.0 14.3 20.7 23.0 16.6 18.8 24.7 21.4 21.4 20.1 22.7 17.5 21.0 21.1 17.6 21.6 20.8 20.3 21.6 21.7 24.2 21.9 22.6 21.5 20.8 19.0 18.1 21.7 23.1 21.8 21.7 22.2 20.5 21.0 21.3 21.6 21.3 21.7 22.0 22.1 22.5 21.7 19.6 22.5 20.5 20.0 22.0 21.3 22.1

37 139 58 0 110 78 88 132 74 91 26 6 13 98 2 23 304 5 5 4 4 2 1 2 4 2 2 1 5 4 3 4 2 2 2 1 7 5 2 4 5 14 2 0 2 8 6 2 6 2 9

0 10 13 0 0 0 0 0 0 0 0 0 0 116 0 0 0 19 0 0 1 0 0 3 0 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 13 0

0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

975.57 2,162.02 1,108.61 2,112.20 1,059.52 808.43 1,131.67 1,355.78 703.41 980.52 1,029.53 1,768.79 838.43 1,984.10 1,668.86 826.45 1,598.68 2,521.18 1,013.53 1,425.63 1,507.72 1,936.91 818.43 1,543.83 1,931.92 1,737.89 2,242.17 1,196.68 1,016.45 1,079.57 963.53 1,241.59 1,614.84 1,089.62 1,597.87 2,714.35 1,104.63 1,805.94 927.51 1,609.80 845.44 1,460.79 1,311.65 1,941.00 983.54 2,029.01 1,036.57 2,648.22 1,128.60 2,459.19 1,547.81

Table S1 page 114/159

Polypeptide Nacetylgalactosaminyltransferase 5

GALT5_HUMAN GALNT5

106,250

100.00%

3

3

11

Fructose-bisphosphate aldolase C

ALDOC_HUMAN ALDOC

39,438

100.00%

9

13

100

VNNSTMLGASGDYADFQYLK 3.51% ALLPEDSGTHQVLR NDNPYSFPK VEVDLDQTQR 46.40% ALQASALNAWR DGADFAK DNAGAATEEFIKR GILAADESVGSMAK GVVPLAGTDGETTTQGLDGLSER

KDGADFAK QVLFSADDR TPSALAILENANVLAR VDKGVVPLAGTDGETTTQGLDGLSER

VLAAVYK YASICQQNGIVPIVEPEILPDGDHDLK YASICQQNGIVPIVEPEILPDGDHDLKR

YEGSGEDGGAAAQSLYIANHAY

Heat shock 70 kDa protein 4

HSP74_HUMAN HSPA4

94,314

100.00%

32

35

178

YTPEEIAMATVTALR 48.50% AESEEMETSQAGSK AFSDPFVEAEK AGGIETIANEYSDR EFSITDVVPYPISLR ELSTTLNADEAVTR EMLNLYIENEGK FLEMCNDLLAR FQESEERPK GCALQCAILSPAFK LEDTENWLYEDGEDQPK LFEELGK LKETAESVLK LMNETTAVALAYGIYK LNLQNK MDQPPQAK MQVDQEEPHVEEQQQQTPAENK MQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSK

NAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDK

Tissue alpha-L-fucosidase

FUCO_HUMAN FUCA1

53,672

100.00%

5

5

24

NAVEEYVYEMR NFTTEQVTAMLLSK NKEDQYDHLDAADMTK QDLPALEEKPR QIQQYMK QSLTMDPVVK SEENEEPMETDQNAK SEENEEPMETDQNAKEEEK SNLAYDIVQLPTGLTGIK STNEAMEWMNNK SVMDATQIAGLNCLR TSTVDLPIENQLLWQIDR VEPPKEEQK VLATAFDTTLGGR 14.20% DGLIVPIFQER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

108.0 71.7 41.2 37.6 66.2 46.1 69.4 86.2 129.0 55.0 57.3 93.2 84.6 45.5 68.3 91.7 114.0 64.9 117.0 51.8 69.1 65.0 78.3 62.1 49.5 44.0 37.1 95.2 30.8 40.5 96.9 33.4 47.6 70.2 42.8 46.1 66.4 88.8 31.3 66.0 33.5 41.8 60.7 34.1 135.0 74.1 88.4 94.1 31.8 114.0 41.2

21.3 21.8 20.5 22.4 22.7 22.6 23.1 22.6 21.5 22.3 23.3 17.1 20.8 18.0 21.0 19.7 19.2 22.9 16.4 21.5 22.0 20.7 23.2 22.3 20.9 22.8 22.6 16.9 20.2 21.0 22.0 23.3 19.4 19.1 13.0 16.3 18.3 21.9 20.2 21.0 21.5 23.0 12.3 13.8 17.2 17.0 22.9 20.6 20.7 21.7 21.6

6 4 4 3 2 14 2 4 46 4 4 12 2 18 0 0 2 3 2 11 13 16 10 2 2 8 1 6 1 3 3 2 4 0 0 0 5 10 0 3 1 3 1 0 25 6 4 4 1 11 2

0 0 0 0 0 0 0 0 9 0 0 2 11 0 5 5 0 1 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 2 0 2 0 0 2 2 0 0 0 1 1 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,210.01 1,535.82 1,081.50 1,202.60 1,200.65 723.33 1,421.70 1,364.67 2,273.13 851.43 1,050.52 1,652.93 2,615.32 763.47 3,020.50 3,176.61 2,243.98 1,681.85 1,483.62 1,239.59 1,495.70 1,735.93 1,519.76 1,452.70 1,397.66 1,149.55 1,535.77 2,080.90 835.46 1,117.65 1,773.91 729.43 930.44 2,638.17 4,118.77 3,366.46 1,418.63 1,582.82 1,893.83 1,295.70 954.47 1,117.59 1,766.70 2,281.93 1,903.05 1,454.60 1,664.81 2,141.12 1,083.57 1,321.71 1,286.71

Table S1 page 115/159

ERO1-like protein alpha

ERO1A_HUMAN ERO1L

54,377

100.00%

7

7

22

18.20%

Glycylpeptide Ntetradecanoyltransferase 1

NMT1_HUMAN NMT1

56,789

100.00%

6

6

13

16.50%

Glycyl-tRNA synthetase

SYG_HUMAN GARS

83,124

100.00%

9

9

20

16.10%

RuvB-like 2

RUVB2_HUMAN RUVBL2

51,140

100.00%

8

8

20

21.00%

40,212

100.00%

6

6

10

25.60%

Vesicular integral-membrane protein LMAN2_HUMAN LMAN2 VIP36

DLVGELGTALR DNYPPGFSYADFGPQFTAR FFHPEEWADLFQAAGAK TQHFVSAK FDGILTEGEGPR LGAVDESLSEETQK LIANMPESGPSYEFHLTR LLESDYFR LQTQGLGTALK QEIVSLFNAFGR YLLQETWLEK AIELFSVGQGPAK DIPVVHQLLTR GFDVFNALDLMENK GSETDSAQDQPVK LGEVVNTHGPVEPDKDNIR SYQFWDTQPVPK APQVDVDK GEFTIETEGK LGDAVEQGVINNTVLGYFIGR LPFAAAQIGNSFR QQGDLVR SPITGNDLSPPVSFNLMFK TLYVEEVVPNVIEPSFGLGR TVNVVQFEPSK VDDSSGSIGR AAGVVLEMIR AVLIAGQPGTGK GLGLDDALEPR LLIVSTTPYSEK QASQGMVGQLAAR TQGFLALFSGDTGEIK TTEMETIYDLGTK VYSLFLDESR DRLVPGPVFGSK LFQLMVEHTPDEESIDWTK LPTGYYFGASAGTGDLSDNHDIISMK

Endoplasmic reticulum aminopeptidase 2

ERAP2_HUMAN ERAP2

110,449

100.00%

9

9

17

ATP-dependent RNA helicase A

DHX9_HUMAN DHX9

140,944

100.00%

9

9

22

NCIDITGVR NLHGDGIALWYTR WTELAGCTADFR 10.60% AAELFSQWMESSGK FDLGSYDIR FPWQELR ILAVTDFEPTQAR LIELGMEGK TQNLAALLHAIAR VLSYPAHEQIALLVPEK VSIYASPDKR YFDIYYPLSK 9.45% AIEPPPLDAVIEAEHTLR DFVNYLVR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0% 95.0% 95.0%

81.9 94.9 28.5 37.3 62.5 91.0 38.9 41.9 41.1 88.1 40.7 58.9 32.2 55.9 32.5 48.8 48.8 51.0 40.3 77.5 73.9 36.5 32.3 65.3 56.8 68.9 57.9 63.3 73.6 64.2 51.9 95.3 74.2 45.2 32.0 31.8 48.7 32.5 30.5 86.3 69.6 50.2 34.5 70.9 33.2 60.0 40.9 30.1 39.5 27.5 39.3

23.1 18.8 22.7 23.5 22.0 23.1 22.8 21.9 20.4 22.2 22.0 22.0 18.1 22.1 19.6 21.8 22.1 20.1 22.1 19.2 21.9 21.5 22.2 19.2 22.5 22.2 22.3 17.6 21.5 19.9 23.0 21.3 22.1 22.8 21.7 21.4 19.3 23.0 22.4 20.5 20.0 22.0 23.4 22.5 23.7 15.7 17.4 22.5 23.1 19.8 22.3

13 7 0 1 2 2 0 2 2 10 2 2 3 1 2 0 3 2 2 2 4 1 2 1 4 2 2 2 2 2 2 4 4 2 0 0 0 1 1 3 2 2 1 5 1 2 1 1 2 0 2

0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 2 0 0 0 0 0 0 0 0 0 0 0 0 1 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,143.64 2,149.96 1,963.93 917.48 1,290.63 1,505.73 2,078.00 1,042.52 1,129.66 1,380.73 1,322.70 1,316.72 1,290.75 1,612.77 1,361.62 2,089.07 1,495.72 871.45 1,110.53 2,235.18 1,391.74 815.44 2,064.05 2,218.18 1,247.66 992.47 1,058.60 1,111.65 1,155.60 1,350.75 1,332.67 1,683.86 1,501.71 1,228.62 1,271.71 2,334.10 2,746.27 1,047.53 1,515.77 1,426.64 1,570.72 1,085.53 975.51 1,460.78 989.53 1,391.81 1,907.06 1,135.61 1,308.65 1,971.06 1,025.54

Table S1 page 116/159

26,671

100.00%

7

7

18

CEAM6_HUMAN CEACAM6

37,177

99.50%

2

3

22

PSMD1_HUMAN PSMD1

105,821

100.00%

5

5

12

APLP2_HUMAN APLP2

86,937

100.00%

17

24

499

40S ribosomal protein S3

RS3_HUMAN

Carcinoembryonic antigen-related cell adhesion molecule 6 26S proteasome non-ATPase regulatory subunit 1

Amyloid-like protein 2

RPS3

DVVQAYPEVR ELDALDANDELTPLGR GMTLVTPLQLLLFASK LGGIGQFLAK QPAIISQLDPVNER TTQVPQFILDDFIQNDR YPSPFFVFGEK 35.40% DEILPTTPISEQK ELAEDGYSGVEVR FGFPEGSVELYAEK GGKPEPPAMPQPVPTA KPLPDHVSIVEPK LLGGLAVR TEIIILATR 9.88% EVLLLAHNLPQNR SDPVTLNVLYGPDGPTISPSK 9.13% DTSEDIEELVEPVAAHGPK EAINLLEPMTNDPVNYVR QDVYDLLK TPEASPEPK TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK

31.10% ADMDQFTASISETPVDVR AKEQLEIR CLVGEFVSDVLLVPEK EEVLQYCQEMYPELQITNVMEANQR

Eukaryotic translation initiation factor 4B

IF4B_HUMAN EIF4B

69,136

100.00%

3

4

20

Proteasome subunit beta type-1

PSB1_HUMAN PSMB1

26,473

100.00%

8

10

69

Kallikrein-10

KLK10_HUMAN KLK10

30,120

100.00%

9

14

231

EMIFNAER EWEEAELQAK GSGVGEQDGGLIGAEEK HYQHVLAVDPEK LNMHVNIQTGK MALENYLAALQSDPPRPHR NKVDENMVIDETLDVK QQLVETHLAR QTLIQHFQAMVK SCFETK SQVMTHLHVIEER VEAMLNDR VPYVAQEIQEEIDELLQEQR VSIDNWCR 7.53% AASIFGGAKPVDTAAR STPKEDDSSASTSQSTR VAPAQPSEEGPGR 43.60% AGGSASAMLQPLLDNQVGFK AMTTGAIAAMLSTILYSR DVFISAAER DVYTGDALR EGIREETVSLR GAVYSFDPVGSYQR LSEGFSIHTR NMQNVEHVPLSLDR 27.20% ALQLPYR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

44.8 49.9 38.8 36.2 59.0 55.4 31.9 86.3 79.4 38.5 45.9 37.4 44.8 37.9 45.4 99.8 41.5 54.3 35.4 47.4 43.7 110.0 43.5 76.5 42.3 43.2 56.6 82.8 46.3 53.3 64.2 47.2 59.7 36.7 42.0 36.4 57.2 62.7 52.9 53.0 40.4 61.0 103.0 73.5 58.8 36.7 46.1 92.4 28.6 72.8 36.0

23.6 21.5 13.4 19.2 20.9 22.0 22.1 22.0 20.8 22.8 23.7 18.8 14.8 15.3 18.3 21.5 21.6 22.1 21.7 21.1 19.0 20.4 22.0 21.6 17.9 22.1 20.9 22.4 22.7 22.2 21.4 22.4 19.3 22.7 16.2 22.4 21.9 21.4 22.0 22.0 19.8 23.3 22.3 22.0 23.3 22.0 23.1 21.4 24.1 22.6 22.6

3 4 2 2 3 4 1 2 3 2 5 0 2 2 4 17 0 4 3 2 0 61 22 5 0 8 28 7 4 6 0 3 19 3 6 0 32 0 16 4 1 13 16 6 10 4 3 11 0 8 5

0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 2 0 0 0 1 2 0 0 1 0 0 0 139 2 49 3 18 0 0 3 0 5 0 2 0 0 4 0 0 0 0 0 1 6 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 88 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,175.61 1,741.86 1,748.00 1,003.59 1,579.84 2,050.02 1,317.65 1,470.77 1,423.67 1,572.76 1,573.81 1,458.83 798.52 1,029.63 1,516.86 2,157.11 2,035.98 2,088.04 993.53 955.47 3,324.53 1,981.92 986.56 1,803.96 3,147.41 1,009.48 1,232.58 1,602.76 1,435.73 1,270.66 2,195.10 1,861.92 1,194.66 1,459.77 771.33 1,578.81 963.46 2,429.22 1,049.48 1,531.82 1,783.79 1,294.64 2,020.02 1,902.97 1,007.52 1,009.50 1,288.69 1,545.73 1,146.59 1,667.82 860.50

Table S1 page 117/159

TXND5_HUMAN TXNDC5

47,611

100.00%

6

6

24

13.70%

Parathyroid hormone-related protein PTHR_HUMAN PTHLH

20,176

100.00%

3

4

9

20.90%

Actin-related protein 2

ARP2_HUMAN ACTR2

44,744

100.00%

3

3

16

9.90%

Dihydrolipoyl dehydrogenase, mitochondrial

DLDH_HUMAN DLD

54,159

100.00%

10

12

33

24.00%

Nucleobindin-1

NUCB1_HUMAN NUCB1

53,862

100.00%

28

36

231

59.90%

Thioredoxin domain-containing protein 5

GLTCSSITILSPK LARPVVPGPR RTDEHDLMLLK TDEHDLMLLK VGDDHLLLLQGEQLR VGDDHLLLLQGEQLRR YHQGSGPILPR YMSWINK EYVESQLQR FVLSQAKDEL GYPTLLLFR GYPTLLWFR IAEVDCTAER TLAPTWEELSKK ATSEVSPNSKPSPNTK FGSDDEGR YLTQETNKVETYK DLMVGDEASELR ILLTEPPMNPTK SMLEVNYPMENGIVR ADGGTQVIDTK ALTGGIAHLFK EANLAASFGK GIEMSEVR GRIPVNTR IPNIYAIGDVVAGPMLAHK NETLGGTCLNVGCIPSK NLGLEELGIELDPR SEEQLKEEGIEYK VGKFPFAANSR AKMDAEQDPNVQVDHLNLLK APAAHPEGQLK DLELLIQTATR EFGDTGEGWETVEMHPAYTEEELR

EKLQAANAEDIK ELDFVSHHVR ELQQAVLHMEQR EVWEELDGLDPNR EVWEELDGLDPNRFNPK FEEELAAR FHPDTDDVPVPAPAGDQK FHPDTDDVPVPAPAGDQKEVDTSEK

KLEEQQR LDELKR LLERLPEVEVPQHL LPEVEVPQHL LQAANAEDIK LSQETEALGR LVTLEEFLASTQR MDAEQDPNVQVDHLNLLK NEEDDMREMEEER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

79.7 29.8 50.0 41.8 88.6 51.3 43.1 41.2 45.2 45.8 50.8 42.7 53.6 37.7 70.8 59.9 65.2 86.3 55.8 70.9 68.4 58.3 32.5 42.6 31.7 80.4 81.7 70.1 62.4 54.7 41.8 52.7 68.5 56.8 64.1 71.6 78.5 59.3 57.7 55.1 76.6 61.9 42.3 35.9 29.1 63.2 54.7 80.5 83.9 121.0 29.8

22.0 9.5 21.8 22.2 19.6 18.1 21.7 21.0 23.0 22.8 18.6 20.9 21.0 22.1 22.8 16.1 23.5 20.7 20.5 21.9 22.7 20.2 23.2 22.1 16.3 19.6 23.1 21.7 22.8 21.7 21.6 23.4 21.1 15.3 23.0 23.0 23.0 21.9 22.3 23.4 21.8 21.2 23.7 23.5 17.8 22.8 21.5 23.4 20.3 21.8 9.0

4 0 6 1 28 1 10 7 2 5 10 4 2 1 2 4 2 5 10 1 2 2 1 2 1 2 2 4 2 0 0 10 9 0 2 4 16 11 2 8 5 0 1 2 0 18 7 15 22 4 0

0 1 35 0 51 22 54 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 10 0 0 3 2 4 0 0 2 0 0 2 0 0 0 2 2 0 0 1 0 0 0 4 11 2

0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,376.75 1,061.66 1,386.71 1,214.61 1,705.92 1,862.03 1,224.65 941.46 1,151.57 1,149.62 1,079.63 1,152.62 1,163.54 1,402.76 1,643.82 882.36 1,616.82 1,350.62 1,353.75 1,783.84 1,104.55 1,127.66 1,007.52 936.45 912.54 1,995.07 1,819.87 1,567.83 1,581.77 1,193.64 2,294.15 1,118.60 1,272.72 2,828.20 1,329.70 1,238.63 1,481.75 1,571.73 2,057.99 964.47 1,905.90 2,694.25 930.50 773.45 1,671.94 1,160.63 1,072.56 1,103.57 1,506.82 2,095.01 1,743.64

Table S1 page 118/159

ES1 protein homolog, mitochondrial ES1_HUMAN

C21orf33

28,152

100.00%

2

2

3

NVDTNQDR QFEHLDPQNQHTFEAR RFEEELAAR VNVPGSQAQLK YLESLGEEQR YLESLGEEQRK YLQEVIDVLETDGHFR 13.10% EVVEAHVDQK ITDLANLSAANHDAAIFPGGFGAAK

NIF3-like protein 1

NIF3L_HUMAN NIF3L1

41,951

100.00%

2

2

8

Prolyl endopeptidase

PPCE_HUMAN PREP

80,684

100.00%

5

5

15

41,498

100.00%

7

9

30

92,454

100.00%

21

24

118

Protein arginine N-methyltransferase ANM1_HUMAN PRMT1 1

Endoplasmin

ENPL_HUMAN HSP90B1

6.37% ALMQVVDFLSR GIDGVSVTSFSAR 11.70% LPEADDIQYPSMLLLTADHDDR NILQLHDLTTGALLK SDGTETSTNLHQK TFPLDVGSIVGYSGQK VFLDPNILSDDGTVALR 25.20% ANKLDHVVTIIK ATLYVTAIEDR DVAIKEPLVDVVDPK TGEEIFGTIGMRPNAK TGFSTSPESPYTHWK VEEVELPVEK WLAPDGLIFPDR 35.00% DISTNYYASQK EAESSPFVER EEASDYLELDTIK EESDDEAAVEEEEEEKKPK EFEPLLNWMK ELISNASDALDK ELISNASDALDKIR FAFQAEVNR FQSSHHPTDITSLDQYVER GLFDEYGSK GVVDSDDLPLNVSR IADDKYNDTFWK IYFMAGSSR LGVIEDHSNR LIINSLYK LISLTDENALSGNEELTVK NLLHVTDTGVGMTR SGTSEFLNK SGYLLPDTK SILFVPTSAPR TDDEVVQREEEAIQLDGLNASQIR

Peroxiredoxin-5, mitochondrial

PRDX5_HUMAN PRDX5

22,008

100.00%

9

11

27

VFITDDFHDMMPK YSQFINFPIYVWSSK 44.90% ETDLLLDDSLVSIFGNR ETDLLLDDSLVSIFGNRR FSMVVQDGIVK GVLFGVPGAFTPGCSK LLADPTGAFGK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

32.0 35.0 42.2 52.3 45.4 51.5 110.0 34.1 39.2 72.8 81.2 64.7 57.8 31.5 73.9 115.0 32.3 56.3 58.3 37.6 48.8 45.7 38.9 59.3 44.4 88.7 49.6 43.0 92.5 108.0 44.4 86.1 57.2 111.0 52.5 38.3 59.3 39.8 75.1 59.9 31.9 46.2 65.1 44.4 33.4 65.3 89.4 38.5 59.7 33.5 33.8

18.6 21.8 23.8 20.5 22.2 22.6 22.8 23.0 21.4 22.2 22.0 20.5 14.9 20.8 21.8 21.5 12.8 21.7 18.7 22.1 21.0 20.6 21.0 20.5 21.7 22.1 18.4 23.1 23.1 21.4 23.1 21.4 19.4 22.1 21.4 21.2 22.4 14.3 21.6 22.0 21.6 21.7 20.6 21.4 17.4 22.6 22.0 20.7 21.7 22.6 22.9

1 3 3 19 4 4 8 1 0 6 2 0 2 1 2 7 0 4 6 2 2 4 2 8 6 4 0 3 15 10 4 0 4 13 2 2 7 4 22 3 1 4 9 0 1 4 7 2 2 1 2

0 3 0 0 0 1 18 0 2 0 0 3 0 0 0 0 4 0 5 1 0 0 0 0 0 0 1 0 0 2 0 4 0 0 0 0 2 0 0 4 0 0 0 4 0 0 0 1 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

961.43 1,996.93 1,120.58 1,140.64 1,223.59 1,351.69 1,933.97 1,153.59 2,442.24 1,294.68 1,295.66 2,544.19 1,649.96 1,417.66 1,667.86 1,844.98 1,350.81 1,251.66 1,636.92 1,736.86 1,724.79 1,170.63 1,399.74 1,289.60 1,150.54 1,525.73 2,219.97 1,322.65 1,275.64 1,544.83 1,081.54 2,260.06 1,015.47 1,485.76 1,515.71 1,047.49 1,139.58 963.59 2,046.06 1,513.78 982.48 993.53 1,187.68 2,728.34 1,627.71 1,878.94 1,906.98 2,063.08 1,238.65 1,593.81 1,089.59

Table S1 page 119/159

THLPGFVEQAEALK VGDAIPAVEVFEGEPGNK VGDAIPAVEVFEGEPGNKVNLAELFK

Heterogeneous nuclear ribonucleoprotein A/B

ROAA_HUMAN HNRNPAB

36,207

100.00%

3

3

34

Carboxypeptidase A4

CBPA4_HUMAN CPA4

47,334

100.00%

18

21

324

VNLAELFK 13.30% EVYQQQQYGSGGR FGEVVDCTIK GFGFILFK MFVGGLSWDTSKK 50.60% APDAEELDK APDAEELDKVAR DPAITSILEK DTGTYGFLLPANQIIPTAEETWLGLK

EWISQATAIWTAR FFGDQVLR IVSDYQR KAPDAEELDK KIVSDYQR LSQLVNSNNLK MDIFLLPVANPDGYVYTQTQNR

NGDEISK NPGSSCIGADPNR RPAVWLNAGIHSR SPSSFNRPVDVLVPSVSLQAFK SQGLEYAVTIEDLQALLDNEDDEMQHNEGQER

Galectin-1

LEG1_HUMAN LGALS1

14,698

100.00%

2

2

4

17.80%

Myoferlin

MYOF_HUMAN MYOF

234,698

99.50%

2

2

4

1.16%

Microtubule-associated protein RP/EB family member 1

MARE1_HUMAN MAPRE1

29,982

100.00%

4

6

11

24.30%

Hyaluronan and proteoglycan link protein 3 Semaphorin-3B

HPLN3_HUMAN HAPLN3

40,876

100.00%

2

2

3

4.44%

SEM3B_HUMAN SEMA3B

83,104

100.00%

6

6

14

10.90%

SVVDFIQK TIMEHVR LNLEAINYMAADGDFK LPDGYEFK GPVGTVSEAQLAR VIVESASNIPK FFDANYDGKDYDPVAAR KPLTSSSAAPQRPISTQR LEHEYIQNFK QGQETAVAPSLVAPALNKPK LTLTEAR VGQLFAAWK AASVLVGEELYSGVAADLMGR AFLGPFAHK DFPDDVIQFAR ETAVEAAPALGR LFVGAENHVASLNLDNISK SAVAQIALHR DHFLMDGQVR GNVLLEDGK GNVLLEDGKGR GTTEGSAVCVFTMK HVSLYQPQLATRPWIQDIEGASAK

INSSLQLPDR ISLPLGSEERPFLR MLLLQPQAR SQSLRPTK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

51.1 95.1 37.6 57.7 98.9 55.7 55.5 43.6 51.0 34.7 66.8 39.4 76.6 59.3 51.6 55.3 40.6 65.6 83.5 53.6 49.6 32.0 54.1 74.9 52.7 43.4 99.2 31.8 72.2 48.0 35.2 36.7 33.6 56.1 30.6 49.0 49.9 31.3 60.0 66.9 46.7 50.2 35.1 41.6 36.0 63.9 39.8 37.3 33.9 55.2 35.3

21.8 22.1 19.2 19.9 21.0 22.7 22.7 23.1 20.1 22.0 20.8 18.8 23.0 23.1 23.1 22.6 20.3 22.2 22.0 22.3 19.1 19.9 18.1 16.9 20.9 22.4 22.4 20.9 21.1 21.9 20.1 19.0 23.4 16.1 23.3 21.3 22.2 23.8 22.6 22.2 21.0 18.2 20.6 21.6 21.0 20.5 20.2 22.4 20.6 22.0 22.5

2 2 0 3 22 13 10 2 8 0 26 0 69 35 6 18 8 26 17 2 1 0 5 0 7 2 3 1 2 2 0 0 1 1 1 2 1 2 3 4 0 2 2 3 2 4 0 1 2 26 5

1 0 4 0 0 0 0 0 0 2 0 3 0 0 0 12 0 0 35 0 0 8 33 1 0 0 0 0 0 0 1 2 0 5 0 0 0 0 0 0 2 0 2 0 0 0 2 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,539.82 1,827.91 2,742.44 933.54 1,499.69 1,167.57 928.53 1,471.73 987.46 1,313.67 1,086.60 2,848.48 1,532.79 981.52 880.45 1,115.56 1,008.55 1,229.69 2,571.26 762.36 1,344.60 1,476.82 2,374.28 3,705.65 935.52 901.46 1,784.85 968.47 1,284.69 1,156.66 1,963.88 1,925.06 1,320.66 2,019.12 803.46 1,019.57 2,124.06 987.54 1,322.64 1,184.63 2,041.07 1,065.62 1,233.57 944.51 1,157.63 1,503.68 2,708.42 1,142.62 1,613.90 1,085.61 916.52

Table S1 page 120/159

STALVVDGELYTGTVSSFQGNDPAISR

Hsp90 co-chaperone Cdc37

CDC37_HUMAN CDC37

44,450

100.00%

4

4

9

19.00%

Obg-like ATPase 1

OLA1_HUMAN OLA1

44,727

100.00%

6

6

21

18.20%

Nck-associated protein 1

NCKP1_HUMAN NCKAP1

128,777

99.50%

2

2

4

2.39%

Inositol polyphosphate 1phosphatase mRNA export factor

INPP_HUMAN INPP1

43,981

99.50%

2

2

2

6.27%

RAE1L_HUMAN RAE1

40,951

100.00%

2

2

4

7.61%

Extracellular matrix protein 1

ECM1_HUMAN ECM1

60,655

100.00%

20

21

239

VPGLHHTYDVLFLGTGDGR EGEEAGPGDPLLEAVPK LGPGGLDPVEVYESLPEELQK QYMEGFNDELEAFKER SMVNTKPEKTEEDSEEVR GGDGIKPPPIIGR IGIVGLPNVGK IPAFLNVVDIAGLVK NYIVEDGDIIFFK VPVPDER YLEANMTQSALPK ELATVLSDQPGLLGPK NNNQQLAQLQK NIFGEESNEFTNDWGEK VASEALAR GLIVYQLENQPSEFR SSNPMMVLQLPER

52.80% ACPSHQPDISSGLELPFPPGVPTLDNIK AWEDTLDKYCDR ELLALIQLER ELPSLQHPNEQK EVGPPLPQEAVPLQK FCEAEFSVK FSCFQEEAPQPHYQLR HPPSPTR LDGFPPGRPSPDNLNQICLPNR LLPAQLPAEK LLPAQLPAEKEVGPPLPQEAVPLQK

LTFINDLCGPR LVWEEAMSR NLPATDPLQR NVALVSGDTENAK QGETLNFLEIGYSR QHVVYGPWNLPQSSYSHLTR QLRPEHFQEVGYAAPPSPPLSR SLPMDHPDSSQHGPPFEGQSQVQPPPSQEATPLQQEK

Far upstream element-binding protein 1

FUBP1_HUMAN FUBP1

67,543

100.00%

9

10

23

Lysyl oxidase homolog 2

LOXL2_HUMAN LOXL2

86,705

99.90%

2

2

3

Fructose-bisphosphate aldolase A

ALDOA_HUMAN ALDOA

39,403

100.00%

28

38

1360

SQGGWGHR 16.50% EMVLELIR IGGDAGTSLNSNDYGYGGQK IGGNEGIDVPIPR IQFKPDDGTTPER IQIAPDSGGLPER IQNDAGVR MVMIQDGPQNTGADKPLR RPLEDGDQPDAK RPLEDGDQPDAKK 2.58% GGAYIGEGR TPVMEGYVEVK 68.70% AAQEEYVK AAQEEYVKR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

37.9 41.8 76.9 91.6 30.7 52.3 38.8 46.3 78.3 45.7 36.6 76.5 46.1 56.2 86.4 31.5 32.9 43.9 33.2 59.4 74.2 68.1 57.8 43.1 41.2 35.5 27.3 36.4 36.5 65.5 61.0 36.0 98.4 111.0 32.5 29.9 21.1 56.4 51.0 85.1 89.8 46.4 77.0 35.0 42.6 38.3 33.9 32.0 43.9 60.5 92.5

21.8 21.9 22.1 20.5 18.2 20.3 18.7 13.2 12.8 23.0 19.0 22.7 18.2 21.4 16.8 23.4 21.7 21.7 20.9 18.2 16.6 22.9 18.8 20.1 20.3 25.0 21.6 14.0 12.0 23.2 22.3 22.1 23.3 22.7 21.5 20.8 17.9 20.1 23.6 19.1 21.4 23.1 21.9 21.3 22.2 22.1 21.9 23.3 22.1 21.6 22.9

0 0 4 3 0 0 0 3 9 1 3 4 2 2 1 1 1 3 0 3 32 15 21 6 0 3 0 7 0 8 30 4 23 57 0 0 0 4 2 2 5 0 2 2 1 2 0 1 2 10 59

1 3 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 6 0 1 0 9 0 0 0 0 0 1 3 0 0 0 0 0 2 0 0 2 0 3 0 0 0 14

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,784.37 2,054.05 1,707.84 2,269.16 2,021.89 2,123.98 1,276.74 1,066.66 1,568.94 1,572.80 811.43 1,481.73 1,637.91 1,298.68 2,015.86 816.46 1,792.92 1,501.75 2,986.50 1,571.68 1,197.72 1,419.72 1,601.89 1,116.50 2,036.93 791.42 2,477.24 1,079.65 2,662.52 1,305.66 1,136.54 1,124.61 1,317.67 1,626.81 2,369.18 2,476.27 4,035.88 884.41 1,002.57 1,973.88 1,336.72 1,503.74 1,352.72 872.46 2,002.97 1,340.65 1,468.74 879.43 1,267.62 937.46 1,093.56

Table S1 page 121/159

ADDGRPFPQVIK ALANSLACQGK ALQASALK CPLLKPWALTFSYGR DGADFAK ELSDIAHR FSHEEIAMATVTALR FSHEEIAMATVTALRR GGVVGIKVDK GILAADESTGSIAK GILAADESTGSIAKR GVVPLAGTNGETTTQGLDGLSER

IGEHTPSALAIMENANVLAR KDGADFAK KELSDIAHR LQSIGTENTEENR LQSIGTENTEENRR PYQYPALTPEQK PYQYPALTPEQKK QLLLTADDR SKGGVVGIK VDKGVVPLAGTNGETTTQGLDGLSER

VLAAVYK YASICQQNGIVPIVEPEILPDGDHDLK YASICQQNGIVPIVEPEILPDGDHDLKR

Fructose-1,6-bisphosphatase 1

F16P1_HUMAN FBP1

36,797

100.00%

8

8

28

Src substrate cortactin

SRC8_HUMAN CTTN

61,567

99.50%

2

2

4

Nidogen-1

NID1_HUMAN NID1

136,358

100.00%

21

25

145

YTPSGQAGAAASESLFVSNHAY 33.40% AGIAHLYGIAGSTNVTGDQVK AISSAVR APVILGSPDDVLEFLK DFDPAVTEYIQR EAVLDVIPTDIHQR GTGELTQLLNSLCTAVK STDEPSEKDALQPGR YVGSMVADVHR 4.18% FGVQSER TQTPPVSPAPQPTEER 19.00% AAECVHR AECLNPSQPSR ALEGLQYPFAVTSYGK ASLHGGEPTTIIR EDLSPSITQR EYTVTEPERDGASPSR GNLYWTDWNR IETSYMDGTNR IYTYQWR KALEGLQYPFAVTSYGK MVYWTDITEPSIGR NGFSITGGEFTR NIFWTDSNLDR NLYFTDWK QAEVTFVGHPGNLVIK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0%

45.4 80.4 64.5 28.3 46.1 56.8 104.0 33.8 34.9 103.0 107.0 140.0 90.9 55.0 36.3 74.9 48.8 67.2 55.1 76.1 43.9 85.1 45.5 68.3 91.7 143.0 31.5 39.7 86.8 67.6 60.3 70.4 61.9 34.4 48.7 42.7 38.6 39.5 75.7 41.9 49.7 46.5 36.9 72.1 35.0 72.3 104.0 61.3 70.8 30.2 29.3

22.1 23.8 22.3 21.8 22.6 21.9 22.3 21.5 20.2 23.5 21.5 21.6 21.2 22.3 22.4 21.9 23.0 23.1 22.8 23.1 20.9 20.9 18.0 21.0 19.7 21.0 21.5 24.8 19.7 22.4 21.3 21.3 22.2 22.4 23.4 22.1 18.6 21.5 22.1 21.5 23.0 22.1 21.4 17.2 22.0 21.3 21.7 21.2 22.2 21.2 19.7

14 16 39 0 14 42 94 0 2 78 8 20 19 4 0 9 3 104 6 27 3 1 18 0 0 204 0 2 13 4 2 2 1 2 2 2 1 1 18 3 6 8 4 8 2 2 11 4 6 1 0

21 0 0 1 0 0 180 0 0 0 4 4 283 0 7 0 7 0 4 0 0 7 0 5 5 12 2 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 3 0 0 0 0 1

0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,342.71 1,132.58 801.48 1,808.95 723.33 940.49 1,691.84 1,831.95 971.59 1,332.70 1,488.80 2,272.14 2,107.10 851.43 1,068.58 1,490.71 1,646.81 1,434.73 1,562.82 1,044.57 844.53 2,614.33 763.47 3,020.50 3,176.61 2,228.03 2,072.08 703.41 1,712.95 1,453.70 1,605.86 1,804.95 1,629.77 1,249.60 822.41 1,734.87 842.39 1,258.59 1,743.90 1,351.73 1,145.58 1,793.83 1,324.61 1,302.56 1,029.52 1,871.99 1,683.81 1,285.62 1,380.65 1,086.53 1,708.94

Table S1 page 122/159

1-phosphatidylinositol-4,5bisphosphate phosphodiesterase beta-3

PLCB3_HUMAN PLCB3

138,785

100.00%

5

5

9

5.51%

Neurolysin, mitochondrial

NEUL_HUMAN NLN

80,636

100.00%

2

2

2

3.27%

Tax1-binding protein 3

TX1B3_HUMAN TAX1BP3

13,717

99.50%

2

2

3

19.40%

Plexin-B2

PLXB2_HUMAN PLXNB2

205,109

100.00%

2

2

3

1.52%

Gamma-glutamylcyclotransferase

GGCT_HUMAN GGCT

20,990

100.00%

6

6

27

37.80%

UPF0364 protein C6orf211

CF211_HUMAN C6orf211

51,156

100.00%

3

3

5

9.75%

Proteasome activator complex subunit 1

PSME1_HUMAN PSME1

28,706

100.00%

9

11

41

36.90%

Alpha-enolase

ENOA_HUMAN ENO1

47,152

100.00%

34

47

2850

77.90%

QCVAEGSPQR QDLGSPEGIAVDHLGR SDIDAVYVTTNGIIATSEPPAK VLFETDLVNPR VYYREDLSPSITQR YALSNSIGPVR EAQVDAEAQR EVVLDANTTQFK LLDGLAQAQAEGR LNEVLYPPLRPSQAR LVAGQQQVLQQLAEEEPK LVNTGLLTLR NLNEDDTFLVFSK RSEEVVR VSEGGPAEIAGLQIGDK EASPNPEDGIVR SSGGPGAGLCLFPLDK ENGLPLEYQEK LDFGNSQGK NPSAAFFCVAR SNLNSLDEQEGVK SYLMTNYESAPPSPQYK VSEEIEDIIK HGEEGVEAEK LRNELQTDKPFIPLVEK TIEDLDENQLKDEFFK APLDIPVPDPVK APLDIPVPDPVKEK EPALNEANLSNLK IEDGNNFGVAVQEK ISELDAFLKEPALNEANLSNLK IVVLLQR NAYAVLYDIILK QLVHELDEAEYR TENLLGSYFPK AAVPSGASTGIYEALELR AGYTDKVVIGMDVAASEFFR AVEHINK DATNVGDEGGFAPNILENK DATNVGDEGGFAPNILENKEGLELLK

DYPVVSIEDPFDQDDWGAWQK EGLELLK EIFDSR FTASAGIQVVGDDLTVTNPK GNPTVEVDLFTSK GVPLYR HIADLAGNSEVILPVPAFNVINGGSHAGNK

IDKLMIEMDGTENK IEEELGSK IGAEVYHNLK KLNVTEQEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

35.8 92.5 53.6 71.6 61.8 81.3 45.7 45.8 36.3 32.2 88.9 47.9 40.9 40.3 93.6 54.0 40.5 59.0 47.2 61.8 74.9 81.0 84.1 33.6 35.8 95.6 47.5 52.0 46.5 77.3 96.1 46.9 86.0 62.2 56.0 161.0 84.9 40.7 111.0 77.3 113.0 42.4 31.7 128.0 110.0 31.4 60.7 72.5 56.8 67.0 52.7

19.8 22.5 21.2 22.5 22.0 22.6 21.0 23.4 21.8 17.1 20.0 16.1 22.5 23.9 21.7 21.7 22.9 22.6 22.7 21.4 22.6 19.9 23.7 20.4 15.9 21.7 18.9 18.5 22.0 22.9 18.4 12.8 18.6 21.6 22.0 21.5 21.7 19.5 21.4 21.6 17.1 20.9 22.0 21.7 23.0 21.6 21.0 22.8 23.5 22.8 23.4

3 6 3 29 2 12 2 1 1 0 4 1 1 1 2 2 1 1 4 2 8 4 8 1 0 2 2 2 2 2 0 4 14 2 7 354 2 20 151 0 22 14 3 277 163 2 0 20 33 69 53

0 6 0 0 3 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 3 0 0 2 0 0 1 0 87 6 0 7 84 4 0 0 38 0 0 11 31 0 30 11

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,131.52 1,663.84 2,262.15 1,302.71 1,726.88 1,176.64 1,116.53 1,364.71 1,341.71 1,752.98 2,008.07 1,099.68 1,541.75 874.47 1,640.85 1,283.62 1,575.78 1,319.65 965.47 1,239.59 1,432.69 1,991.91 1,174.62 1,084.49 2,040.15 1,983.96 1,260.72 1,517.86 1,412.74 1,519.74 2,429.29 840.57 1,395.79 1,501.73 1,268.65 1,804.94 2,192.07 810.45 1,960.93 2,743.38 2,510.12 801.47 766.37 2,033.06 1,406.72 704.41 3,011.57 1,652.79 904.46 1,143.62 1,088.60

Table S1 page 123/159

LAMQEFMILPVGAANFR LAQANGWGVMVSHR LMIEMDGTENK LNVTEQEK LNVTEQEKIDK NFRNPLAK SCNCLLLK SGETEDTFIADLVVGLCTGQIK SGKYDLDFK SPDDPSR TIAPALVSK VNQIGSVTESLQACK VVIGMDVAASEFFR YDLDFK YDLDFKSPDDPSR YGKDATNVGDEGGFAPNILENK

N-acetylglucosamine-1phosphotransferase subunit gamma Follistatin-related protein 1

GNPTG_HUMAN GNPTG

33,956

99.90%

2

2

4

13.40%

FSTL1_HUMAN FSTL1

34,967

100.00%

5

5

70

14.90%

Protocadherin Fat 1

FAT1_HUMAN FAT1

506,251

100.00%

5

5

10

1.55%

Annexin A10

ANX10_HUMAN ANXA10

37,261

100.00%

10

10

50

31.80%

Adenylosuccinate synthetase isozyme 2

PURA2_HUMAN ADSS

50,080

100.00%

6

7

17

18.60%

Annexin A3

ANXA3_HUMAN ANXA3

36,359

100.00%

17

20

179

48.00%

YISPDQLADLYK YNQLLR QWDQVEQDLADELITPQGHEK VVEEPNAFGVNNPFLPQASR GAQTQTEEEMTR ICANVFCGAGR LDSSEFLK LSFQEFLK YVQELQK AEISEFAPPNTPVVMVK AFEVNPQGVLLTSSAIK IGEETGVIETSDR IVSGDSENLFK VQATDADAGLNRK DKPAYFAYR DTLMNLVQGTR GVGTDENCLIEILASR LYSAIHDFGFHNK MMIAEAYQSMYGR SEIDLLTIR SLFHDIR SYQQLR TMLQMILCNK TNGEIFQMR ELPVNAQNYVR FIEDELQIPVK LDGEIIPHIPANQEVLNK LDILDMFTEIK TLPGWNTDISNAR VGIGAFPTEQDNEIGELLQTR ALLTLADGR ALLTLADGRR DISQAYYTVYK DISQAYYTVYKK DYPDFSPSVDAEAIQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

114.0 41.4 78.8 55.3 42.9 35.2 47.0 98.1 50.1 44.9 49.6 139.0 117.0 38.8 68.8 52.0 90.8 37.6 28.6 62.4 82.0 49.8 43.2 57.1 37.7 37.5 67.6 47.4 31.8 27.1 38.2 65.0 92.1 19.6 102.0 71.2 34.0 34.0 46.6 71.1 37.0 52.9 38.8 89.6 60.0 107.0 64.9 36.2 64.5 44.0 85.8

21.5 22.1 19.9 23.7 22.8 23.8 22.3 22.2 21.5 16.5 15.9 22.8 22.6 19.7 20.5 21.7 22.9 22.8 22.0 22.1 17.6 21.5 22.3 21.0 21.5 22.7 19.3 22.3 23.3 22.9 22.4 23.6 22.2 22.6 16.1 21.9 22.6 22.0 22.9 22.0 23.2 22.5 18.9 21.8 22.3 21.0 21.2 19.4 22.6 22.8 21.1

297 0 79 25 3 5 13 6 10 5 13 186 349 5 11 0 169 68 0 3 41 7 5 16 1 1 6 1 1 0 2 9 4 0 6 20 1 1 2 4 2 5 0 2 2 2 13 2 11 4 19

41 3 0 0 0 0 0 0 54 0 0 2 0 0 6 4 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 2 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,923.98 1,525.77 1,296.58 960.50 1,316.71 959.54 1,007.50 2,353.16 1,072.53 773.34 899.56 1,633.82 1,556.78 800.38 1,554.71 2,309.11 1,425.73 806.45 2,479.17 2,185.10 1,396.60 1,224.56 938.48 1,011.55 907.49 1,844.95 1,773.98 1,405.68 1,208.62 1,358.70 1,130.56 1,247.64 1,746.87 1,548.76 1,598.67 1,059.61 887.47 794.42 1,251.63 1,095.53 1,302.68 1,330.73 2,000.08 1,353.70 1,444.72 2,287.16 929.54 1,085.64 1,350.66 1,478.75 1,781.82

Table S1 page 124/159

EYQAAYGK GAGTNEDALIEILTTR GIGTDEFTLNR HYGYSLYSAIK MLISILTER NTPAFLAER QDAQILYK SDTSGDYEITLLK SEIDLLDIR SLGDDISSETSGDFR SLGDDISSETSGDFRK VDEHLAK AVELLR FILNLPTFSVR NGIHDLDNISFPK NGYELSPTAAANFTR VAASNIVQMK VAASNIVQMKDDHDK GIMGEDTYPYQGK GNFVSPVK GTGPYPPSVDWR LQTFASNWR MALNQFSDMSFAEIK TPDKVNHAVLAVGYGEK TYSTEEYHHR VNHAVLAVGYGEK FDQNLDTK NSWGPEWGSNGYVK VFREPLFLDLPK ALYLSDNDFEILPPDIGK EIGELTQLK LQILSLR LTVLPPELGNLDLTGQK DTDSSVASEVR ELANFDPSRPGPPSGR IQASQQDDSMR QGNAVTLGDYYQGR SSSAGGQGSYVPLLR AASITSEVFNK GNENANGAPAITLLIR LAESVEK SLFSSIGEVESAK TNLIVNYLPQNMTQDELR VLVDQTTGLSR AYAALAALEK EDITQSAQHALR LNQLKPGLQYK VLAGETLSVNDPPDVLDR VLQDMGLPTGAEGR

Proteasome subunit beta type-2

PSB2_HUMAN PSMB2

22,820

100.00%

6

6

31

29.90%

Cathepsin H

CATH_HUMAN CTSH

37,376

100.00%

8

10

161

25.10%

Cathepsin L2

CATL2_HUMAN CTSL2

37,311

100.00%

3

3

24

10.20%

Ras suppressor protein 1

RSU1_HUMAN RSU1

31,524

100.00%

4

4

8

18.40%

Lipolysis-stimulated lipoprotein receptor

LSR_HUMAN LSR

71,421

100.00%

5

5

238

10.30%

FACT complex subunit SPT16

SP16H_HUMAN SUPT16H

119,899

100.00%

3

3

10

3.25%

ELAV-like protein 1

ELAV1_HUMAN ELAVL1

36,075

100.00%

3

3

10

12.90%

Interleukin enhancer-binding factor 3 ILF3_HUMAN ILF3

95,321

100.00%

5

5

21

7.27%

PPT1_HUMAN PPT1

34,176

100.00%

4

4

34

21.20% CPSPPMINLISVGGQHQGVFGLPR ETIPLQETSLYTQDR

Palmitoyl-protein thioesterase 1

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

48.3 117.0 75.0 39.7 66.4 41.2 58.5 87.1 73.7 83.3 85.4 43.7 38.8 56.0 67.6 90.0 75.8 67.9 87.2 30.6 44.8 44.0 107.0 61.2 42.3 59.7 42.0 42.2 42.9 46.5 36.7 35.0 48.1 70.6 29.9 77.9 92.0 102.0 75.9 67.8 38.6 51.3 46.6 85.5 47.8 40.7 42.6 83.1 59.9 38.4 88.7

18.5 22.4 23.3 22.2 21.0 24.0 22.6 21.8 24.9 18.9 20.8 19.0 22.0 17.0 22.3 22.0 23.4 21.6 20.1 23.6 21.6 23.3 20.7 20.4 18.7 22.1 22.0 20.9 18.2 22.3 21.9 19.6 15.7 21.0 22.6 19.1 22.1 22.6 22.7 20.2 25.1 22.1 21.8 22.3 20.2 23.4 18.4 21.2 23.2 20.4 22.6

3 35 14 1 23 2 8 14 10 5 4 4 3 10 2 2 12 2 52 2 18 15 55 1 1 6 11 2 0 2 2 2 2 28 0 102 44 63 6 2 2 3 1 6 1 1 2 7 10 0 16

0 3 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 11 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

929.44 1,673.87 1,222.61 1,301.65 1,075.62 1,018.53 978.53 1,441.71 1,073.58 1,585.70 1,713.79 811.43 700.44 1,306.75 1,469.74 1,611.78 1,076.58 1,686.81 1,458.66 847.47 1,331.64 1,122.57 1,731.81 1,797.95 1,322.58 1,356.73 980.47 1,580.71 1,473.85 2,020.03 1,030.58 842.55 1,808.02 1,165.53 1,696.84 1,294.57 1,541.73 1,478.76 1,166.61 1,623.88 775.42 1,353.69 2,162.09 1,188.66 1,020.57 1,368.69 1,301.76 1,909.99 1,459.72 2,577.31 1,793.89

Table S1 page 125/159

Ornithine aminotransferase, mitochondrial

OAT_HUMAN OAT

48,518

100.00%

4

4

10

12.30%

X-ray repair cross-complementing protein 5

XRCC5_HUMAN XRCC5

82,689

100.00%

8

10

25

11.10%

Ribonuclease inhibitor

RINI_HUMAN RNH1

49,956

100.00%

8

8

28

23.00%

Dystroglycan

DAG1_HUMAN DAG1

97,424

100.00%

7

8

63

12.40%

Stathmin

STMN1_HUMAN STMN1

17,285

100.00%

4

5

9

30.90%

Selenide, water dikinase 1

SPS1_HUMAN SEPHS1

42,893

99.50%

2

2

4

8.42%

Dihydropteridine reductase

DHPR_HUMAN QDPR

25,772

100.00%

2

2

5

14.30%

Polymerase I and transcript release factor

PTRF_HUMAN PTRF

43,459

100.00%

8

10

30

22.30%

Cathepsin Z

CATZ_HUMAN CTSZ

33,850

100.00%

5

6

52

19.50%

Myosin light polypeptide 6

MYL6_HUMAN MYL6

16,912

100.00%

6

8

20

46.40%

GINESYKK LQQGYNAMGFSQGGQFLR GIYLWDVEGR LPSDVVTAVR TVQGPPTSDDIFER VAIAALEVLEEENLAENADK ANPQVGVAFPHIK EEASGSSVTAEEAK EEASGSSVTAEEAKK FSEEQR LGGHGPSFPLK VITMFVQR YAPTEAQLNAVDALIDSMSLAK YAYDKR ELCQGLGQPGSVLR ELSLAGNELGDEGAR ELTVSNNDINEAGVR LDDCGLTEAR LEDAGVR LGDVGMAELCPGLLHPSSR VNPALAELNLR WAELLPLLQQCQVVR EGAMSAQLGYPVVGWHIANK IPSDTFYDHEDTTTDKLK LFDMSAFMAGPGNAK LGCSLNQNSVPDIHGVEAPAR LREQQLVGEK SFSEVELHNMK VTIPTDLIASSGDIIK AIEENNNFSK ASGQAFELILSPR DLSLEEIQK SKESVPEFPLSPPK ESFNPESYELDK IIEVAPQVATQNVNPTPGATS MTDSFTEQADQVTAEVGK NRPSSGSLIQVVTTEGR AHATTSNTVSK GEAGDLR IIGAVDQIQLTQAQLEER IREGQVEVLK KLEVNEAELLR QAEMEGAVQSIQGELSK VMIYQDEVK VMIYQDEVKLPAK IVTSTYKDGK NSWGEPWGER NVDGVNYASITR STYPRPHEYLSPADLPK VGDYGSLSGR ALGQNPTNAEVLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

34.1 121.0 52.8 54.7 76.6 94.3 46.9 103.0 75.7 31.3 39.2 32.7 113.0 32.0 52.8 110.0 112.0 51.9 40.6 57.3 69.9 62.4 49.7 29.9 95.9 45.8 51.9 44.5 122.0 53.6 35.1 48.3 36.2 60.4 71.3 141.0 55.6 32.2 32.4 148.0 26.5 65.7 130.0 33.7 30.6 36.0 40.2 80.3 36.8 83.2 55.9

20.3 21.8 22.0 19.8 22.5 22.0 20.1 20.1 21.9 20.8 20.8 21.6 21.6 20.5 22.1 21.9 22.3 21.0 23.4 22.1 18.2 19.1 22.5 21.6 20.1 22.1 22.0 21.4 18.2 21.8 22.4 24.0 21.7 19.1 21.3 19.4 20.8 22.0 20.8 19.0 19.5 19.9 22.2 23.2 21.4 20.6 17.6 22.6 22.2 21.6 21.4

2 15 2 4 2 2 2 6 4 3 2 1 3 1 3 4 4 2 1 0 7 4 1 0 23 0 3 7 21 2 1 2 2 2 2 3 0 1 1 6 0 4 7 1 0 1 2 26 0 12 2

0 0 0 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 3 0 0 2 3 0 3 0 0 0 0 0 0 2 0 0 0 2 0 0 4 1 3 0 0 2 0 0 0 9 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

938.49 2,001.96 1,207.61 1,056.61 1,561.75 2,141.10 1,377.76 1,394.63 1,522.72 795.36 1,109.61 1,009.55 2,321.17 815.41 1,513.78 1,530.74 1,630.80 1,149.52 759.40 2,024.99 1,209.70 1,853.01 2,144.06 2,125.99 1,588.71 2,234.10 1,199.68 1,336.62 1,642.93 1,165.55 1,388.75 1,074.57 1,541.82 1,457.64 2,107.10 1,972.88 1,800.96 1,116.56 717.35 2,025.10 1,170.68 1,313.74 1,804.88 1,140.56 1,549.83 1,111.60 1,217.53 1,308.65 1,971.00 1,010.49 1,354.73

Table S1 page 126/159

Plasminogen activator inhibitor 2

PAI2_HUMAN SERPINB2

Transcriptional activator protein Pur- PURB_HUMAN PURB beta

46,580

100.00%

13

14

66

33,224

100.00%

3

3

5

EAFQLFDR ILYSQCGDVMR NKDQGTYEDYVEGLR SDEMNVK VLDFEHFLPMLQTVAK 36.40% ANFSGMSER GKIPNLLPEGSVDGDTR GSYPDAILQAQAADK IPNLLPEGSVDGDTR ITNCILFFGR LEEHYELR LNIGYIEDLK MAEDEVEVYIPQFK MVLVNAVYFK SLSSAINASTGNYLLESVNK SMGMEDAFNK TPVQMMYLR YYSSEPQAVDFLECAEEAR 24.40% DSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPR GGGEQETQELASK GGGGFGAGPGPGGLQSGQTIALPAQGLIEFR

V-type proton ATPase subunit S1

VAS1_HUMAN ATP6AP1

52,009

99.50%

2

2

7

Actin-related protein 2/3 complex subunit 3 DAZ-associated protein 1

ARPC3_HUMAN ARPC3

20,530

100.00%

2

2

3

DAZP1_HUMAN DAZAP1

43,365

99.50%

2

2

4

60 kDa SS-A/Ro ribonucleoprotein

RO60_HUMAN TROVE2

60,654

100.00%

5

6

17

Syntenin-1

SDCB1_HUMAN SDCBP

32,427

100.00%

3

3

7

Uncharacterized protein LP9056

L9056_HUMAN LP9056

63,530

100.00%

5

5

32

EGF-containing fibulin-like extracellular matrix protein 1

FBLN3_HUMAN EFEMP1

54,621

100.00%

11

11

120

6.81% EVLTGNDEVIGQVLSTLK LGASPLHVDLATLR 13.50% DTDIVDEAIYYFK LIGNMALLPIR 7.62% LFVGGLDWSTTQETLR SQAPGQPGASQWGSR 10.80% ALLQEMPLTALLR LGLENAEALIR QIANSQDGYVWQVTDMNR SFSQEGR WRPDEEILK 21.50% DSTGHVGFIFK LYPELSQYMGLSLNEEEIR VIQAQTAFSANPANPAILSEASAPIPHDGNLYPR

9.24% ALFPSLGTYDLEK AMEQEFSATK GLLYQLFR KDHVLDIPTTQR VSSLASASR 23.10% ADQVCINLR ELPQSIVYK FSCMCPQGYQVVR GSFACQCPPGYQK IPSNPSHR LNCEDIDECR NNFVIR NPCQDPYILTPENR QTSPVSAMLVLVK RNPADPQR SGNENGEFYLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

52.8 67.4 79.1 31.0 51.8 40.5 57.3 86.3 64.7 69.5 26.8 73.3 58.2 43.0 106.0 36.7 51.5 110.0 45.0 43.6 47.4 73.2 39.7 68.1 61.2 112.0 77.4 77.3 72.8 75.2 35.8 55.3 36.1 90.3 36.5 48.7 66.7 39.7 29.2 75.0 49.2 35.7 58.7 84.6 45.5 53.9 35.2 63.8 76.1 35.9 53.4

22.6 20.5 21.5 20.9 20.9 20.5 21.3 23.2 22.0 21.4 22.5 21.7 21.6 19.4 21.4 12.8 23.2 17.8 20.3 22.4 19.8 19.2 18.3 22.2 15.1 21.8 21.3 16.3 21.6 21.4 20.8 21.6 22.0 22.1 18.8 22.2 21.4 19.1 20.8 23.3 23.4 21.8 17.2 17.2 22.9 13.4 23.7 21.3 19.8 22.2 19.7

2 2 2 1 6 2 3 7 9 7 0 10 1 1 8 1 4 3 0 2 0 5 0 1 2 2 2 8 4 1 1 2 4 2 0 9 10 5 0 7 3 1 2 14 13 1 3 9 58 2 14

0 0 2 0 3 0 9 0 0 0 1 0 0 0 0 0 0 0 1 0 2 0 2 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,025.51 1,357.62 1,786.83 822.37 1,888.00 1,014.43 1,767.92 1,547.77 1,582.81 1,240.65 1,088.54 1,177.65 1,713.80 1,183.65 2,068.06 1,161.46 1,138.58 2,263.98 3,255.52 1,333.62 2,867.48 1,915.04 1,462.84 1,591.75 1,210.73 1,822.93 1,513.71 1,468.86 1,198.68 2,124.98 810.37 1,185.63 1,207.61 2,300.11 3,530.80 1,453.76 1,141.52 1,009.58 1,422.77 877.47 1,088.55 1,076.60 1,647.71 1,499.64 907.48 1,323.53 762.43 1,716.80 1,372.79 953.49 1,285.58

Table S1 page 127/159

UPF0160 protein MYG1, mitochondrial 26S proteasome non-ATPase regulatory subunit 13

MYG1_HUMAN C12orf10

42,432

99.50%

2

2

4

PSD13_HUMAN PSMD13

42,901

100.00%

3

3

6

Acyl-coenzyme A thioesterase 1

ACOT1_HUMAN ACOT1

46,260

99.50%

2

2

4

Glutaminyl-tRNA synthetase

SYQ_HUMAN QARS

87,782

99.50%

2

2

6

Leucine-rich alpha-2-glycoprotein

A2GL_HUMAN LRG1

38,162

100.00%

3

3

15

Desmoglein-2

DSG2_HUMAN DSG2

122,276

100.00%

18

21

221

Beta-lactamase-like protein 2

LACB2_HUMAN LACTB2

32,789

100.00%

2

2

9

12,757

100.00%

6

6

11

SH3 domain-binding glutamic acid- SH3L1_HUMAN SH3BGRL rich-like protein

6.91% AMDLVQEEFLQR FQVDPSGEIVELAK 11.20% LNIGDLQVTK QMTDPNVALTFLEK TAWGQQPDLAANEAQLLR 7.36% DGYADIVDVLNSPLEGPDQK GPGVGLLGISK 2.58% FDDTNPEKEEAK LFTLTALR 11.00% DLLLPQPDLR TLDLGENQLETLPPDLLR VAAGAFQGLR 18.30% AWITAPVALR DGNGEVTDKPVK DNWISVDSVTSEIK EETPFFLLTGYALDAR GITEPPFGIFVFNK GNNVEKPLELR GQIIGNFQAFDEDTGLPAHAR ILDVNDNIPVVENK IVAISEDYPR IVAISEDYPRK IVSLEPAYPPVFYLNK LEDRDNWISVDSVTSEIK LPDFESR QAQVQIR QESTSVLLQQSEK QESTSVLLQQSEKK VLEGMVEENQVNVEVTR VVPSFLPVDQGGSLVGR 9.38% EQQILTLFR ILIDTGEPAIPEYISCLK 78.10% DIAANEENRK ENNAVYAFLGLTAPPGSK ENVPENSRPATGYPLPPQIFNESQYR

Hsc70-interacting protein

F10A1_HUMAN ST13

Nicotinate phosphoribosyltransferase PNCB_HUMAN NAPRT1

Matrix metalloproteinase-28

MMP28_HUMAN MMP28

Charged multivesicular body protein CHM4B_HUMAN CHMP4B 4b 4F2 cell-surface antigen heavy chain 4F2_HUMAN SLC3A2

41,314

100.00%

3

3

23

10.00%

57,561

100.00%

3

3

5

7.06%

58,923

99.50%

2

2

5

5.19%

24,933

99.50%

2

2

4

11.20%

67,978

100.00%

6

6

29

13.70%

GDYDAFFEAR QQDVLGFLEANK VYIASSSGSTAIK AIDLFTDAIK AIEINPDSAQPYK VAAIEALNDGELQK AAFVAYALAFPR LDSGDLLQQAQEIR SPAQYQVVLSER AFQWVSQLPVSGVLDR GGLQVEPYYPR EALENANTNTEVLK GGPTPQEAIQR ADLLLSTQPGREEGSPLELER GENSWFSTQVDTVATK GQSEDPGSLLSLFR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.5% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

83.4 42.0 42.0 55.7 106.0 91.8 62.2 36.9 46.2 35.7 66.7 74.9 38.5 56.6 56.2 43.0 79.7 56.4 119.0 82.4 68.1 30.1 54.9 83.2 34.5 37.0 99.2 38.8 76.8 55.9 55.8 64.9 35.3 52.7 53.1 41.3 77.8 45.2 57.5 53.8 109.0 30.0 87.6 65.9 71.0 52.3 45.0 45.9 37.2 56.3 85.3

22.5 23.6 21.5 22.9 21.7 22.0 14.6 20.5 14.9 19.0 20.0 22.0 18.1 22.4 23.1 22.1 20.4 21.5 21.2 20.9 23.2 21.6 18.6 22.7 24.0 20.0 22.9 22.3 22.5 19.5 20.4 21.7 22.3 22.0 20.1 16.3 23.9 21.5 22.0 23.0 21.8 19.5 22.0 22.6 21.4 22.3 23.0 22.8 20.8 21.3 22.7

2 2 3 2 1 2 2 2 4 2 7 6 5 4 4 1 17 6 4 35 12 0 44 4 3 2 10 2 28 2 7 2 1 2 0 2 2 2 10 3 10 1 2 2 2 3 2 2 0 2 12

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 18 0 0 1 0 16 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,494.73 1,531.80 1,100.63 1,622.81 1,982.01 2,145.04 997.60 1,422.64 934.57 1,179.67 2,037.09 989.55 1,097.65 1,258.63 1,592.78 1,842.93 1,565.84 1,268.70 2,257.10 1,581.85 1,162.61 1,290.71 1,850.01 2,106.04 863.43 842.48 1,476.75 1,604.85 1,944.97 1,726.95 1,147.65 2,032.07 1,159.57 1,848.95 3,003.46 1,190.51 1,361.71 1,283.68 1,106.61 1,445.73 1,470.78 1,296.71 1,585.82 1,376.72 1,801.96 1,278.65 1,545.78 1,153.60 2,310.19 1,769.83 1,505.76

Table S1 page 128/159

Mitotic checkpoint protein BUB3

BUB3_HUMAN BUB3

37,137

100.00%

6

6

9

19.80%

Serpin B6

SPB6_HUMAN SERPINB6

42,605

100.00%

6

7

45

23.40%

Splicing factor, arginine/serine-rich 6 SFRS6_HUMAN SFRS6

39,570

100.00%

5

5

21

14.00%

LDHB_HUMAN LDHB

36,621

100.00%

13

15

160

42.20%

Protein arginine N-methyltransferase ANM5_HUMAN PRMT5 5 U2 small nuclear ribonucleoprotein RU2A_HUMAN SNRPA1 A'

72,667

99.50%

2

2

4

3.61%

28,399

100.00%

3

3

6

15.70%

Sodium/potassium-transporting ATPase subunit alpha-1

AT1A1_HUMAN ATP1A1

112,882

100.00%

7

7

35

9.78%

Aminopeptidase B

AMPB_HUMAN RNPEP

72,579

100.00%

13

14

34

28.20%

L-lactate dehydrogenase B chain

LLTSFLPAQLLR VAEDEAEAAAAAK VILDLTPNYR LNQPPEDGISSVK LYDVPANSMR QGYVLSSIEGR QVTDAETKPK VAVEYLDPSPEVQK VLVWDLR ELNMIIMLPDETTDLR GNTAAQMAQILSFNK IAELLSPGSVDPLTR LVLVNAVYFR NLGMTDAFELGK SGGGGDIHQGFQSLLTEVNK ALDKLDGTEINGR LIEDKPR LIVENLSSR QAGEVTYADAHK VIVEHAR EKLIAPVAEEEATVPNNK FIIPQIVK GEMMDLQHGSLFLQTPK GLTSVINQK IVADKDYSVTANSK IVVVTAGVR LIAPVAEEEATVPNNK LKDDEVAQLK LKGEMMDLQHGSLFLQTPK LNLVQR MVVESAYEVIK SADTLWDIQK SLADELALVDVLEDK SLADELALVDVLEDKLK VIGSGCNLDSAR AAILPTSIFLTNK VPLVAPEDLR LTAELIEQAAQYTNAVR NAIANASTLAEVER SLTYLSILR AVFQANQENLPILK GVGIISEGNETVEDIAAR NMVPQQALVIR QGAIVAVTGDGVNDSPALK SPDFTNENPLETR TSATWLALSR VDNSSLTGESEPQTR AEFGPPGPGAGSR AFFPCFDTPAVK AIEAVAISPWK EEYNGVIEEFLATGEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

40.9 32.0 50.5 41.4 36.7 49.5 32.9 59.4 33.5 79.4 98.8 76.0 50.2 56.1 86.9 67.7 43.6 52.6 51.6 44.6 79.2 42.0 53.4 53.7 97.5 61.8 88.2 45.0 29.6 48.6 76.7 75.9 115.0 37.2 73.9 48.2 52.0 77.8 63.1 53.4 52.3 103.0 34.8 87.6 89.9 86.7 89.7 39.7 31.7 65.7 72.0

12.0 21.8 21.5 22.8 21.7 22.6 24.0 23.2 22.0 22.4 23.1 19.3 16.8 21.8 21.8 22.5 18.0 21.6 21.4 18.7 21.4 16.0 21.9 22.1 21.2 17.0 20.5 23.5 21.5 18.8 21.9 23.4 21.6 17.6 21.7 16.7 19.0 22.6 22.9 17.0 19.5 22.0 21.4 20.8 20.6 22.9 21.3 22.5 22.2 20.6 22.4

8 1 5 2 1 1 1 2 2 3 11 14 4 6 2 2 1 11 3 4 1 3 2 14 13 18 20 5 0 25 21 22 27 1 3 3 1 2 2 2 4 2 1 4 5 2 17 4 1 2 3

0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 6 0 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,371.84 1,245.60 1,203.67 1,383.71 1,181.56 1,208.63 1,116.59 1,573.81 900.53 1,935.94 1,593.81 1,567.87 1,193.70 1,295.63 2,044.01 1,401.73 870.51 1,030.59 1,289.61 823.48 1,952.03 957.61 1,963.93 959.55 1,510.78 913.58 1,694.90 1,158.64 2,205.11 742.46 1,267.66 1,176.59 1,629.86 1,871.04 1,248.60 1,388.82 1,108.64 1,890.99 1,458.76 1,065.63 1,584.88 1,829.92 1,284.71 1,811.95 1,519.70 1,105.60 1,619.75 1,199.58 1,399.67 1,184.67 1,827.87

Table S1 page 129/159

ETFASTASQLHSNVVNYVQQIVAPK

Delta-aminolevulinic acid dehydratase Eukaryotic translation initiation factor 3 subunit J

HEM2_HUMAN ALAD

36,277

99.50%

2

2

3

EIF3J_HUMAN EIF3J

29,045

100.00%

4

5

9

Aminoacylase-1

ACY1_HUMAN ACY1

45,866

100.00%

8

9

17

40S ribosomal protein SA

RSSA_HUMAN RPSA

32,836

100.00%

6

6

38

Actin-related protein 2/3 complex subunit 2

ARPC2_HUMAN ARPC2

34,316

100.00%

8

8

15

Thimet oligopeptidase

THOP1_HUMAN THOP1

78,823

100.00%

9

10

24

Protein disulfide-isomerase A6

PDIA6_HUMAN PDIA6

48,104

100.00%

6

6

19

IEPGVDPDDTYNETPYEK LGDTYPSISNAR QHMDITGEENPLNK RPLHSAQAVDVASASNFR TYQLVYFLDK VDIIPGFEFDR VKIEPGVDPDDTYNETPYEK YTLPLYHAMMGGSEVAQTLAK 9.09% AAVLEAMTAFR GSAADSEESPAIEAIHLLR 20.50% ETFGVNNAVYGIDAMNPSSR LQEESDLELAK RLEEPEEPK VLTPEEQLADKLR 28.70% AGFALDEGIANPTDAFTVFYSER AVGVPALGFSPMNR DMNLTLEPEIMPAATDNR EGSVTSVNLTK FMEDTAAEK GPEEEHPSVTLFR TVQPKPDYGAAVAFFEETAR VVNSILAFR 24.10% AIVAIENPADVSVISSR DPEEIEKEEQAAAEK FAAATGATPIAGR FTPGTFTNQIQAAFR KSDGIYIINLK SDGIYIINLK 25.00% ASHTAPQVLFSHR DNTINLIHTFR DSIVHQAGMLK ELQAHGADELLK ELQAHGADELLKR IIEETLALK MILLEVNNR NCFASVFEK 14.90% ETQENIKR FYLDLYPR LKPLGEQER NILDFPQHVSPSK QANTGLFNLR TSQTVATFLDELAQK VDQALHTQTDADPAEEYAR WDLSAQQIEER YYMNQVEETR 21.80% DGELPVEDDIDLSDVELDDLGKDEL GESPVDYDGGR GSTAPVGGGAFPTIVER LAAVDATVNQVLASR NLEPEWAAAASEVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

30.0 106.0 42.5 38.8 33.3 67.5 34.2 37.1 39.5 43.1 27.1 94.0 53.0 33.4 58.9 58.0 32.6 68.6 50.4 49.7 62.1 45.8 69.2 108.0 54.9 83.8 89.0 31.2 59.6 38.5 38.6 49.2 47.9 27.8 57.4 49.8 30.5 34.1 33.8 34.1 65.5 54.4 74.9 79.2 68.5 53.0 66.5 40.7 97.8 101.0 31.3

20.4 17.9 23.2 21.5 21.0 24.1 22.8 21.6 21.2 22.1 22.4 21.8 23.0 22.6 20.6 21.1 23.3 20.9 22.7 19.1 22.5 21.4 17.9 19.2 21.7 23.4 21.8 17.4 21.6 22.5 22.5 21.8 21.8 22.0 17.6 22.8 19.1 23.2 22.9 20.3 23.0 22.7 22.3 20.0 21.3 18.7 20.1 18.4 22.8 20.6 22.2

0 4 2 2 0 5 2 0 0 2 0 1 2 1 3 1 2 1 2 2 2 0 4 13 1 9 9 1 5 0 2 2 2 0 2 3 1 1 3 0 2 2 5 1 2 3 2 2 2 3 1

3 0 0 1 1 0 0 2 2 0 1 0 0 0 2 0 0 0 0 0 1 2 0 0 0 0 0 0 0 2 0 0 0 1 0 0 0 0 0 2 0 0 0 3 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,731.41 2,081.92 1,293.64 1,641.75 1,925.99 1,289.68 1,307.66 2,309.08 2,313.13 1,179.62 1,965.99 2,157.99 1,274.65 1,126.57 1,511.84 2,491.18 1,431.74 2,062.94 1,134.60 1,057.45 1,497.73 2,197.09 1,018.60 1,740.95 1,715.80 1,203.65 1,698.86 1,263.73 1,135.64 1,450.76 1,343.71 1,198.63 1,323.69 1,479.79 1,029.62 1,101.61 1,101.50 1,017.53 1,086.56 1,069.60 1,481.78 1,133.61 1,651.85 2,129.97 1,374.67 1,332.59 2,758.27 1,151.50 1,615.84 1,527.85 1,514.75

Table S1 page 130/159

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

ECH1_HUMAN ECH1

35,798

100.00%

5

5

15

Neuropilin-2

NRP2_HUMAN NRP2

104,843

100.00%

2

2

6

Antileukoproteinase

SLPI_HUMAN SLPI

14,308

100.00%

6

6

11

5'-nucleotidase

5NTD_HUMAN NT5E

63,351

99.50%

2

2

3

AP-2 complex subunit beta

AP2B1_HUMAN AP2B1

104,537

100.00%

3

3

8

Adenylate kinase isoenzyme 1

KAD1_HUMAN AK1

21,617

100.00%

5

5

9

Tumor protein D54

TPD54_HUMAN TPD52L2

22,220

100.00%

5

5

18

Ribulose-phosphate 3-epimerase

RPE_HUMAN RPE

24,910

99.50%

2

2

3

14-3-3 protein epsilon

1433E_HUMAN YWHAE

29,157

100.00%

19

24

347

TGEAIVDAALSALR 17.10% MMADEALGSGLVSR SPVAVQSTK VIGNQSLVNELAFTAR VNLLYSR YQETFNVIER 2.69% SGEIAIDDIR VFQANNDATEVVLNK 41.70% AGVCPPK CCMGMCGK CLDPVDTPNPTR SAQCLR SCVSPVK YKKPECQSDWQCPGK 4.18% FPILSANIK GPLASQISGLYLPYK 4.27% LASQANIAQVLAELK MEPLNNLQVAVK NVEGQDMLYQSLK 27.80% EVQQGEEFER GFLIDGYPR GQLVPLETVLDMLR IIFVVGGPGSGK VDDNEETIK 42.70% GLLSDSMTDVPVDTGVAAR LGLSTLGELK TPAVEGLTEAEEEELR TSAALSTVGSAISR VVGDRENGSDNLPSSAGSGDKPLSDPAPF

11.40% IGPSILNSDLANLGAECLR SVINLLR 71.00% AAFDDAIAELDTLSEESYK AASDIAMTELPPTHPIR DNLTLWTSDMQGDGEEQNK DNLTLWTSDMQGDGEEQNKEALQDVEDENQ

DSTLIMQLLR EAAENSLVAYK EALQDVEDENQ HLIPAANTGESK IISSIEQK IISSIEQKEENK KEAAENSLVAYK LAEQAER LAEQAERYDEMVESMK LICCDILDVLDK LICCDILDVLDKHLIPAANTGESK

NLLSVAYK QMVETELK VAGMDVELTVEER YDEMVESMK YDEMVESMKK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

97.7 98.7 53.3 79.9 47.9 32.0 51.3 72.3 43.4 50.6 66.8 37.9 36.6 45.6 31.9 33.4 58.9 46.1 53.5 43.2 38.9 64.7 58.8 47.9 103.0 59.0 62.3 70.1 32.2 91.9 35.0 121.0 81.8 115.0 76.9 79.3 67.4 65.5 54.5 48.1 76.5 58.1 59.4 49.0 78.4 34.9 51.4 58.5 104.0 49.6 34.3

22.3 21.5 23.0 20.6 20.7 21.9 23.8 22.7 21.0 0.0 21.9 23.8 25.0 19.9 17.6 19.3 17.6 22.3 22.3 21.2 22.1 20.2 18.7 21.2 22.2 17.9 21.6 22.2 20.0 20.9 21.0 20.9 22.0 18.2 15.2 21.3 23.2 17.1 22.5 22.6 22.6 22.0 21.6 20.1 23.3 20.2 19.1 24.0 22.5 13.0 17.9

9 6 2 2 4 1 4 2 2 3 2 1 1 0 2 1 2 4 2 2 2 3 1 1 4 8 1 4 0 2 1 21 36 7 0 113 31 5 4 8 8 5 36 1 16 0 49 19 63 11 1

0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 10 38 0 5 0 0 0 1 0 0 0 0 9 0 0 0 0 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,386.76 1,468.68 916.51 1,731.94 864.49 1,298.64 1,088.56 1,661.85 728.38 1,019.32 1,384.65 734.36 776.40 1,910.85 1,002.60 1,606.88 1,568.90 1,371.73 1,540.73 1,250.57 1,037.54 1,599.88 1,130.66 1,062.50 1,919.94 1,030.62 1,772.86 1,320.71 2,885.36 2,013.04 814.52 2,087.97 1,819.94 2,180.94 3,467.47 1,189.66 1,194.60 1,289.55 1,237.65 917.53 1,417.75 1,322.70 816.42 1,928.87 1,476.74 2,695.38 907.53 993.49 1,463.71 1,163.46 1,275.56

Table S1 page 131/159

YLAEFATGNDR YLAEFATGNDRK IADGYEQAAR QQISLATQMVR WVGGPEIELIAIATGGR FEHCNFNDVTTR LRENELTYYCCK EGPFGTLVYTIK WDQLTLSQR DTVIVWPR FYGSPEELAR VVQPTLEQTQYSWER HAETSSGGQAASSQEQAR LAQAYYESTR QGSSVSQDSDSEGHSEDSER

T-complex protein 1 subunit epsilon TCPE_HUMAN CCT5

59,654

100.00%

3

3

15

7.02%

CD59 glycoprotein

CD59_HUMAN CD59

14,159

99.50%

2

3

5

18.80%

Metalloproteinase inhibitor 3

TIMP3_HUMAN TIMP3

24,128

99.90%

2

2

6

9.95%

Amiloride-sensitive amine oxidase [copper-containing]

ABP1_HUMAN ABP1

85,360

100.00%

3

3

6

4.39%

Filaggrin

FILA_HUMAN FLG

435,128

100.00%

4

4

6

1.75%

Heat shock protein beta-1

HSPB1_HUMAN HSPB1

22,765

100.00%

11

11

69

59.00% AQLGGPEAAK GPSWDPFR

QSGTPHAETSSGGQAASSHEQAR

KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK

LATQSNEITIPVTFESR LFDQAFGLPR QLSSGVSEIR RVPFSLLR TKDGVVEITGK VPFSLLR VSLDVNHFAPDELTVK YTLPPGVDPTQVSSSLSPEGTLTVEAPMPK

Heterogeneous nuclear ribonucleoprotein F

HNRPF_HUMAN HNRNPF

45,654

100.00%

3

4

49

Proteasome subunit alpha type-1

PSA1_HUMAN PSMA1

29,538

100.00%

12

14

60

Ras-related protein Rab-14

RAB14_HUMAN RAB14

23,880

100.00%

9

9

21

15.90% ATENDIYNFFSPLNPVR HSGPNSADSANDGFVR ITGEAFVQFASQELAEK VHIEIGPDGR YIEVFK 44.10% AMSIGAR AQPAQPADEPAEK AQPAQPADEPAEKADEPMEH AQSELAAHQK ETLPAEQDLTTK IHQIEYAMEAVK LLCNFMR LVSLIGSK NQYDNDVTVWSPQGR NVSIGIVGK THAVLVALK TQIPTQR 54.00% ADLEAQR GAAGALMVYDITR IYQNIQDGSLDLNAAESGVQHKPSAPQGGR

LQIWDTAGQER NLTNPNTVIILIGNK STYNHLSSWLTDAR TGENVEDAFLEAAK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

62.7 55.1 91.7 59.0 33.8 65.5 45.6 55.4 43.7 49.4 34.0 84.4 40.3 40.0 30.5 18.6 54.9 33.8 75.0 80.1 86.6 61.5 37.1 28.2 49.2 70.7 37.4 74.0 98.5 111.0 44.3 32.9 44.8 60.4 75.1 33.8 66.5 44.1 34.3 55.4 86.6 46.5 36.8 33.5 63.8 48.8 41.0 61.5 53.4 30.4 85.2

21.1 22.4 23.5 23.1 19.8 17.8 20.6 20.6 23.9 21.0 22.6 22.4 20.1 21.5 12.8 19.1 20.5 21.3 19.5 21.2 22.3 23.6 15.8 22.1 19.3 21.7 20.7 22.4 19.3 21.4 22.2 19.7 23.7 21.7 17.8 21.2 23.0 22.7 22.3 17.2 24.9 21.7 13.4 22.7 22.0 22.5 20.6 22.2 15.3 22.3 22.9

21 19 12 2 1 2 2 4 2 2 2 2 0 2 0 0 5 2 0 11 21 4 2 0 3 8 0 23 8 36 3 2 3 10 5 2 6 6 1 3 12 3 1 3 3 1 0 7 3 0 2

0 0 0 0 0 1 0 0 0 0 0 0 2 0 1 0 0 0 11 0 0 0 0 1 0 0 1 1 3 0 1 0 0 0 0 0 0 4 0 0 1 0 0 0 0 0 0 0 0 1 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,256.59 1,384.69 1,093.53 1,290.68 1,738.95 1,539.67 1,648.75 1,324.72 1,146.59 985.55 1,168.56 1,863.92 1,801.81 1,201.59 2,122.84 2,281.02 941.51 961.45 3,242.65 1,905.99 1,163.62 1,075.57 987.61 1,146.64 831.51 1,783.92 3,114.56 1,996.98 1,630.72 1,867.94 1,092.58 798.44 721.37 1,351.65 2,176.95 1,082.56 1,345.69 1,447.73 953.47 816.52 1,778.81 886.54 951.60 843.47 802.41 1,337.69 3,150.56 1,316.66 1,623.94 1,650.79 1,493.71

Table S1 page 132/159

Vacuolar protein sorting-associated protein 26A

VP26A_HUMAN VPS26A

38,153

100.00%

11

11

26

GrpE protein homolog 1, mitochondrial

GRPE1_HUMAN GRPEL1

24,261

100.00%

3

3

6

3,2-trans-enoyl-CoA isomerase, mitochondrial

D3D2_HUMAN DCI

TGENVEDAFLEAAKK YIIIGDMGVGK 41.90% EITGIGPSTTTETETIAK ELALPGELTQSR EYDLIVHQLATYPDVNNSIK FESPESQASAEQPEM HYLFYDGESVSGK IQHMELQLIK LFLAGYDPTPTMR QQEIILWR SNTHEFVNLVK YEIMDGAPVK YEIMDGAPVKGESIPIR 21.20% DLLEVADVLEK NSGQNLEEDMGQSEQKADPPATEK

32,799

100.00%

5

5

16

Poliovirus receptor-related protein 1 PVRL1_HUMAN PVRL1

57,140

100.00%

4

5

71

Proteasome activator complex subunit 3

PSME3_HUMAN PSME3

29,489

100.00%

3

3

6

Importin subunit beta-1

IMB1_HUMAN KPNB1

97,153

100.00%

16

19

70

NADP-dependent malic enzyme

MAOX_HUMAN ME1

64,133

100.00%

5

6

11

WD repeat-containing protein 1

WDR1_HUMAN WDR1

66,175

100.00%

11

13

47

TLRPALVGVVK 16.90% AVQELWLR DADVQNFVSFISK ILADNPR SLQMYLER VLVEPDAGAGVAVMK 12.80% GPINYSLAGTYICEATNPIGTR LKGEAEYQEIR QNVAIYNPSMGVSVLAPYR VEFLRPSFTDGTIR 16.10% ITSEAEDLVANFFPK SNQQLVDIIEK TVESEAASYLDQISR 25.70% AAVENLPTFLVELSR ANFDKESER ESCLEAYTGIVQGLK GALQYLVPILTQTLTK GDQENVHPDVMLVQPR LAATNALLNSLEFTK LLETTDRPDGHQNNLR LQQVLQMESHIQSTSDR SDYDMVDYLNELR SNEILTAIIQGMR SSAYESLMEIVK TVSPDRLELEAAQK VAALQNLVK VLANPGNSQVAR YLEVVLNTLQQASQAQVDK YMEAFKPFLGIGLK 16.10% DMAAFNERPIIFALSNPTSK GSEYDDFLDEFMEAVSSK QITDNIFLTTAEVIAQQVSDK QQLNIHGLLPPSFNSQEIQVLR TATVYPEPQNK 24.40% AHDGGIYAISWSPDSTHLLSASGDK DYSGQGVVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

34.8 36.2 75.6 67.2 68.4 49.0 44.3 28.0 67.8 45.7 34.4 34.0 36.3 70.7 36.4 34.4 49.6 103.0 38.4 44.7 76.3 96.7 61.0 125.0 57.0 57.0 31.6 82.1 90.6 56.2 68.9 51.9 48.5 110.0 32.9 27.4 77.4 72.8 51.5 38.0 45.7 79.6 115.0 28.4 49.7 94.9 127.0 33.2 45.0 49.5 41.0

22.2 22.3 22.1 21.9 20.6 14.6 22.0 19.3 22.5 22.1 22.5 22.2 22.5 22.2 18.5 7.0 22.3 22.2 19.4 22.0 20.8 21.9 22.8 20.7 21.5 22.7 22.7 21.8 19.7 21.3 22.2 12.0 22.0 20.1 22.5 22.1 18.6 22.5 21.4 21.9 16.9 21.5 20.3 21.3 21.9 15.1 19.8 17.3 23.2 21.6 21.8

0 1 5 5 1 3 1 0 4 2 0 1 0 2 0 0 2 4 2 6 2 1 13 31 0 3 1 2 12 2 2 5 2 15 1 0 2 6 3 2 3 6 2 0 0 2 2 0 2 0 1

2 0 0 0 0 0 0 1 0 0 1 0 2 0 2 2 0 0 0 0 0 0 4 0 22 0 0 0 2 0 0 0 2 0 1 1 0 0 0 0 0 0 0 1 2 0 2 1 0 3 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,621.81 1,181.62 1,848.94 1,313.71 2,332.18 1,682.69 1,501.70 1,252.71 1,497.74 1,085.61 1,287.67 1,138.55 1,890.96 1,243.68 2,619.15 1,152.75 1,014.57 1,469.73 798.45 1,055.52 1,455.79 2,368.16 1,335.69 2,079.07 1,637.87 1,680.85 1,286.70 1,668.81 1,658.91 1,095.51 1,667.83 1,759.04 1,849.89 1,605.89 1,878.94 2,015.98 1,632.72 1,445.78 1,372.67 1,556.83 955.59 1,225.67 2,147.14 1,629.87 2,238.12 2,084.86 2,334.22 2,531.37 1,247.63 2,585.23 952.47

Table S1 page 133/159

Latent-transforming growth factor beta-binding protein 4

LTBP4_HUMAN LTBP4

173,410

100.00%

19

21

186

FATASADGQIYIYDGK IIGGDPK KVFASLPQVER LATGSDDNCAAFFEGPPFK LYSILGTTLKDEGK NIDNPALADIYTEHAHQVVVAK VFASLPQVER YAPSGFYIASGDVSGK YEYQPFAGK 14.50% AEAAAPYTVLAQSAPR CSCAPGYR DGGCSLPILR DVDECQLFR EDGYSDASGFGYCFR EICPAGPGYHYSASDLR GCQLCPPFGSEGFR GGYTCVCPDGFLLDSSR GYLAPSGDLSLR LSPQGTR NPQVCGPGR QICCCSR RVPPPCAPGR SSCISQHVISEAK TQEVCCR TSAGTFPGSQPQAPASPVLPARPPPPPLPR

Alpha-actinin-1

ACTN1_HUMAN ACTN1

103,043

100.00%

30

39

368

VPPPCAPGR VSGPWEEADAEAVAR VSLSQPR YNTRPLGQEPPR 67.60% AGTQIENIEEDFR AGTQIENIEEDFRDGLK AIMTYVSSFYHAFSGAQK ALDFIASK ASIHEAWTDGK ATLPDADKER CQLEINFNTLQTK DDPLTNLNTAFDVAEK DHSGTLGPEEFK DLLLDPAWEK DQALTEEHAR DYETATLSEIK EGLLLWCQR ELPPDQAEYCIAR ETADTDTADQVMASFK FAIQDISVEETSAK GISQEQMNEFR GYEEWLLNEIR HEAFESDLAAHQDR HRPELIDYGK HTNYTMEHIR ICDQWDNLGALTQK

95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

80.4 31.8 26.5 83.3 77.0 35.5 46.9 80.0 35.4 122.0 47.7 41.3 37.5 85.8 64.9 58.0 91.9 33.3 32.3 49.8 34.2 38.6 27.5 34.8 63.2 31.6 99.1 44.1 38.4 71.5 79.1 87.6 64.7 48.0 51.9 92.7 101.0 30.8 50.4 52.5 64.5 48.2 73.8 121.0 104.0 52.0 101.0 51.6 44.5 41.5 105.0

22.5 18.8 20.4 19.3 19.2 21.1 22.7 22.1 21.7 22.8 14.9 23.1 20.5 13.0 20.6 18.9 18.8 22.9 22.6 19.9 13.0 23.3 21.4 16.6 16.9 22.7 22.0 23.1 23.0 21.9 22.1 22.3 21.2 20.6 21.9 22.9 22.9 20.4 22.0 22.3 22.6 23.4 21.1 17.8 22.3 19.9 23.5 20.1 21.8 20.6 21.8

12 2 0 3 4 0 4 8 3 30 2 18 1 3 2 12 5 1 2 6 1 0 0 1 0 1 29 12 1 4 4 31 17 20 16 4 10 1 7 4 3 26 14 26 225 18 73 0 0 0 4

0 0 1 0 3 1 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 1 1 0 42 0 0 0 4 0 7 13 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 4 29 15 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,719.82 699.40 1,273.73 2,043.91 1,537.85 2,418.24 1,145.63 1,618.78 1,102.52 1,615.84 970.39 1,087.56 1,181.53 1,730.68 1,892.86 1,611.71 1,903.83 1,248.66 758.42 984.47 983.39 1,106.59 1,445.71 952.40 2,988.61 950.49 1,586.75 786.45 1,427.74 1,521.72 1,934.95 2,023.96 864.48 1,214.58 1,115.57 1,608.81 1,762.85 1,316.61 1,199.63 1,169.56 1,269.62 1,174.60 1,561.73 1,745.75 1,537.78 1,354.61 1,421.71 1,625.73 1,227.65 1,301.61 1,661.80

Table S1 page 134/159

IDQLEGDHQLIQEALIFDNK ILAGDKNYITMDELR IMSIVDPNR ISIEMHGTLEDQLSHLR IVQTYHVNMAGTNPYTTITPQEINGK

KDDPLTNLNTAFDVAEK KHEAFESDLAAHQDR LAILGIHNEVSK LASDLLEWIR LDHLAEK LLETIDQLYLEYAK LMLLLEVISGER LSNRPAFMPSEGR LVSIGAEEIVDGNVK MEEIGR MLDAEDIVGTARPDEK MTLGMIWTIILR MVSDINNAWGCLEQVEK QFGAQANVIGPWIQTK QKDYETATLSEIK RDQALTEEHAR TFTAWCNSHLR TINEVENQILTR TIPWLENR VEQIAAIAQELNELDYYDSPSVNAR

Filamin-A

FLNA_HUMAN FLNA

280,711

100.00%

72

88

1231

VGWEQLLTTIAR VLAVNQENEQLMEDYEK VPENTMHAMQQK YLDIPK 39.60% AEGPGLSR AFGPGLQGGSAGSPAR AGGPGLER AGNNMLLVGVHGPR AGQSAAGAAPGGGVDTR AHVVPCFDASK ALTQTGGPHVK ANLPQSFQVDTSK ASGPGLNTTGVPASLPVEFTIDAK

ATCAPQHGAPGPGPADASK AWGPGLEGGVVGK AYGPGIEPTGNMVK CSGPGLER DAGEGLLAVQITDPEGKPK DAPQDFHPDR DLAEDAPWK DLAEDAPWKK DVDIIDHHDNTYTVK EAGAGGLAIAVEGPSK EATTEFSVDAR EGPYSISVLYGDEEVPR ENGVYLIDVK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

100.0 30.4 41.5 32.2 52.3 104.0 48.4 55.3 101.0 45.8 81.6 43.2 38.1 123.0 30.8 83.3 97.4 114.0 80.2 70.0 58.8 33.2 86.4 36.2 75.6 92.8 136.0 40.7 35.7 47.3 96.4 79.5 59.6 90.0 32.3 44.4 73.7 90.5 42.9 76.9 65.6 52.7 99.3 40.3 31.6 40.9 48.7 90.2 85.5 100.0 36.9

21.2 21.4 22.9 21.8 20.8 22.1 21.5 16.9 22.0 19.3 19.8 19.6 23.5 21.4 23.0 22.3 20.2 20.4 20.9 22.2 22.2 22.0 22.5 20.3 22.0 20.5 21.1 20.6 19.0 20.5 22.4 20.7 22.7 21.9 22.1 21.2 23.0 20.0 21.6 21.7 22.4 20.5 21.1 20.0 20.5 22.5 22.5 21.6 20.8 22.3 22.8

4 0 8 0 0 8 0 6 38 13 10 1 1 72 3 12 49 5 13 7 1 1 61 2 1 180 15 6 14 9 46 30 0 30 1 21 50 30 0 32 46 6 13 7 1 2 4 15 25 39 4

16 2 0 2 3 7 6 0 0 0 0 0 6 0 0 10 0 0 0 2 13 0 0 0 6 0 0 0 0 0 0 0 26 0 0 0 0 1 5 0 0 0 8 3 0 0 0 0 0 0 0

0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,339.19 1,751.90 1,044.55 1,995.00 2,890.44 1,890.95 1,753.83 1,293.75 1,215.67 825.45 1,711.92 1,388.78 1,477.72 1,542.84 734.35 1,775.85 1,479.81 2,008.91 1,757.93 1,525.78 1,325.66 1,392.65 1,429.77 1,028.55 2,808.37 1,386.77 2,067.95 1,429.66 748.42 786.41 1,429.72 756.40 1,450.76 1,442.70 1,230.59 1,108.61 1,434.72 2,342.22 1,789.83 1,226.65 1,433.71 875.40 1,938.02 1,197.53 1,044.50 1,172.60 1,784.85 1,426.75 1,225.57 1,909.92 1,149.62

Table S1 page 135/159

FGGEHVPNSPFQVTALAGDQPSVQPPLR

FNEEHIPDSPFVVPVASPSGDAR FTVETR FVPAEMGTHTVSVK GAGTGGLGLAVEGPSEAK GKLDVQFSGLTK GLVEPVDVVDNADGTQTVNYVPSR

GQHVPGSPFQFTVGPLGEGGAHK

GTVEPQLEAR IANLQTDLSDGLR IPEISIQDMTAQVTSPSGK IQQNTFTR KGEITGEVR LDVQFSGLTK LIALLEVLSQK LLGWIQNK LPQLPITNFSR LSPFMADIR LTVSSLQESGLK LVSNHSLHETSSVFVDSLTK LYSVSYLLK NDNDTFTVK NGHVGISFVPK SAGQGEVLVYVEDPAGHQEEAK

SPFEVYVDK SPFEVYVDKSQGDASK SPFSVAVSPSLDLSK SPYTVTVGQACNPSACR TFSVWYVPEVTGTHK TGVAVNKPAEFTVDAK TGVELGKPTHFTVNAK TPCEEILVK VANPSGNLTETYVQDR VAQPTITDNKDGTVTVR VDVGKDQEFTVK VEPGLGADNSVVR VGSAADIPINISETDLSLLTATVVPPSGR

VHGPGIQSGTTNKPNK VKAEGPGLSR VKETADFK VKVEPSHDASK VLPTHDASK VNQPASFAVSLNGAK VNVGAGSHPNK VPVHDVTDASK VQVQDNEGCPVEALVK VTAQGPGLEPSGNIANK VTVLFAGQHIAK VTYTPMAPGSYLISIK WGDEHIPGSPYR YAPSEAGLHEMDIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

63.0 53.4 33.4 37.9 98.9 38.5 117.0 20.8 58.9 116.0 107.0 42.6 40.9 57.7 65.7 65.3 53.8 46.8 76.2 52.3 37.0 34.9 29.6 65.6 64.4 68.7 75.4 67.2 42.2 84.4 26.9 41.3 120.0 72.0 64.8 58.5 31.6 53.9 47.0 32.1 43.2 44.2 67.2 57.0 58.0 101.0 102.0 69.2 67.7 42.2 52.8

20.3 22.1 20.3 22.8 22.4 20.4 21.5 21.9 22.7 21.5 21.8 22.3 23.4 22.2 13.4 22.2 20.0 23.2 21.5 21.2 21.5 20.3 20.8 21.5 21.8 21.7 21.7 20.3 22.5 21.7 20.8 23.2 22.7 21.5 22.9 22.5 15.8 22.1 18.9 20.9 21.7 19.8 22.8 22.6 22.6 22.5 21.9 17.9 21.6 21.2 21.3

0 0 2 2 37 1 15 0 25 60 11 12 2 4 17 37 22 15 10 0 4 2 0 0 29 1 37 1 2 17 0 2 36 15 20 11 0 4 17 1 0 2 4 5 27 12 60 11 41 1 6

22 17 0 0 0 0 5 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 18 0 5 0 0 11 16 1 0 0 9 5 0 2 3 0 0 2 0 0 1 13 0 0 1 0 2 0

0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,945.49 2,467.19 752.39 1,518.76 1,570.81 1,292.72 2,544.26 2,304.15 1,099.57 1,415.75 2,002.02 1,007.53 988.54 1,107.61 1,226.77 971.57 1,285.73 1,049.55 1,261.70 2,200.13 1,085.62 1,053.49 1,154.63 2,313.10 1,083.54 1,756.84 1,533.82 1,867.84 1,750.88 1,646.88 1,698.92 1,088.57 1,763.86 1,814.96 1,364.71 1,312.69 2,893.55 1,634.86 1,013.57 937.50 1,196.63 967.52 1,502.80 1,079.56 1,167.60 1,784.89 1,652.86 1,283.75 1,756.92 1,413.66 1,604.74

Table S1 page 136/159

Receptor-type tyrosine-protein phosphatase F

PTPRF_HUMAN PTPRF

212,860

100.00%

20

21

103

12.90%

Glutathione S-transferase omega-1

GSTO1_HUMAN GSTO1

27,549

100.00%

8

8

58

34.90%

Structural maintenance of chromosomes protein 3

SMC3_HUMAN SMC3

141,529

100.00%

8

8

14

8.87%

Nuclear ubiquitous casein and cyclin-dependent kinases substrate

NUCKS_HUMAN NUCKS1

27,279

100.00%

5

5

8

21.80%

Glucosamine 6-phosphate Nacetyltransferase

GNA1_HUMAN GNPNAT1

20,731

100.00%

4

4

14

31.50%

14-3-3 protein sigma

1433S_HUMAN SFN

27,757

100.00%

14

18

282

63.70%

YGGDEIPFSPYR YGGPYHIGGSPFK YGGQPVPNFPSK YNEQHVPGSPFTAR YTPVQQGPVGVNVTYGGDPIPK AAGTEGPFQEVDGVATTR AGLGEEFEK AHTDVGPGPESSPVLVR EHSSWDLVGLEK FEVIEFDDGAGSVLR GPPSEAVR GSGPLSPSIQSR GSSAGGLQHLVSIR LENGEPR NVLELSNVVR SDMGVGVFTPTIEAR TAQSTPSAPPQK TDEDVPSGPPR TGEQAPSSPPR TGEQAPSSPPRR TQQGVPAQPADFQAEVESDTR VGGSMLTPR VLAFTAVGDGPPSPTIQVK YSAPANLYVR YSIGGLSPFSEYAFR EDPTVSALLTSEK EFTKLEEVLTNK GSAPPGPVPEGSIR HEVININLK LNECVDHTPK MILELFSK NKPEWFFK VPSLVGSFIR ALDQFVNFSEQK EENAEQQALAAK ELGSLPQEAFEK GALTGGYYDTR GSGSQSSVPSVDQFTGVGIR INQMATAPDSQR KGDVEGSQSQDEGEGSGESER LAQATQER ATVTPSPVK LKATVTPSPVK NSQEDSEDSEDKDVK VGRPTASK VVDYSQFQESDDADEDYGR ITLECLPQNVGFYK LLLSTLTLLSK MKPDETPMFDPSLLK VLGQLTETGVVSPEQFMK DSTLIMQLLR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

71.6 27.3 51.9 48.2 101.0 116.0 52.7 68.7 33.0 106.0 43.1 38.6 65.2 30.5 58.2 71.2 43.4 39.8 71.1 45.9 93.1 48.4 82.1 52.5 55.8 76.8 81.8 72.9 49.5 53.2 40.4 30.5 54.3 76.7 59.8 42.4 50.4 82.5 57.7 56.2 34.4 38.1 41.0 67.6 33.4 125.0 49.5 65.6 31.1 102.0 79.3

20.3 22.8 22.1 22.1 20.5 22.8 22.0 22.1 21.9 22.4 20.2 22.2 21.1 20.5 22.0 22.6 21.8 21.4 22.2 22.0 20.8 24.0 18.0 23.1 22.6 23.7 21.6 23.0 18.8 21.0 19.2 21.8 18.8 23.2 21.6 22.4 21.0 21.7 22.0 15.3 22.9 19.2 17.1 16.5 24.0 12.8 21.6 6.0 22.1 21.9 21.3

19 0 27 5 24 11 2 2 0 5 2 3 2 1 8 6 8 3 20 0 2 4 11 5 2 4 2 7 21 4 8 0 10 1 2 1 1 2 4 0 1 2 1 1 2 2 2 5 1 6 113

0 2 0 12 10 0 0 3 1 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,400.65 1,379.68 1,290.65 1,602.77 2,286.18 1,805.87 979.47 1,717.89 1,399.69 1,653.81 812.43 1,185.62 1,381.76 814.41 1,142.65 1,595.77 1,212.62 1,169.54 1,126.55 1,282.65 2,274.06 933.48 1,897.04 1,153.60 1,693.82 1,389.71 1,450.78 1,320.69 1,079.62 1,212.57 980.55 1,095.56 1,074.63 1,425.70 1,301.63 1,347.68 1,173.55 1,964.97 1,347.63 2,166.90 916.49 899.52 1,140.70 1,724.71 815.47 2,237.91 1,681.86 1,201.78 1,780.85 1,979.02 1,189.66

Table S1 page 137/159

Integrin beta-1

ITB1_HUMAN ITGB1

88,397

100.00%

7

8

33

Adenylate kinase 2, mitochondrial

KAD2_HUMAN AK2

26,461

100.00%

6

6

18

96,007

100.00%

12

12

36

Programmed cell death 6-interacting PDC6I_HUMAN PDCD6IP protein

EMPPTNPIR GAVEKGEELSCEER GEELSCEER KEMPPTNPIR LAEQAER LAEQAERYEDMAAFMK MKGDYYR NLLSVAYK NLLSVAYKNVVGGQR SAYQEAMDISK SAYQEAMDISKK SNEEGSEEKGPEVR TTFDEAMADLHTLSEDSYK VETELQGVCDTVLGLLDSHLIK VLSSIEQK YEDMAAFMK YLAEVATGDDK YLAEVATGDDKK 9.90% IGFGSFVEK LKPEDITQIQPQQLVLR SAVTTVVNPK SGEPQTFTLK SLGTDLMNEMR TVMPYISTTPAK WDTGENPIYK 31.00% APSVPAAEPEYPK AVLLGPPGAGK LQAYHTQTTPLIEYYR LVSDEMVVELIEK NGFLLDGFPR QAEMLDDLMEK 18.40% ELPELLQR EPSAPSIPTPAYQSSPAGGHAPTPPTPAPR

FYNELTEILVR KADLVNR LALASLGYEK LANQAADYFGDAFK LLDEEEATDNDLR NLATAYDNFVELVANLK SLLSNLDEVKK SVIEQGGIQTVDQLIK TMQGSEVVNVLK YYDQICSIEPK Arylsulfatase A

ARSA_HUMAN ARSA

53,571

99.50%

2

2

3

Activated RNA polymerase II transcriptional coactivator p15

TCP4_HUMAN SUB1

14,378

100.00%

6

6

11

8.09% DPGENYNLLGGVAGATPEVLQALK GGLPLEEVTVAEVLAAR 35.40% EQISDIDDAVR EQISDIDDAVRK EYWMDPEGEMKPGR GISLNPEQWSQLK GISLNPEQWSQLKEQISDIDDAVR

VLIDIR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

50.8 66.0 40.6 34.0 59.4 67.8 42.7 51.4 56.6 75.3 78.9 105.0 92.6 32.9 65.9 57.4 95.4 51.0 53.2 60.0 55.8 34.7 42.8 32.1 34.3 62.1 39.9 34.0 93.3 68.0 47.0 64.8 57.3 66.8 34.5 47.8 74.3 110.0 72.6 43.8 115.0 68.6 48.0 70.5 70.8 62.8 34.8 32.7 69.9 56.6 38.7

21.8 20.0 15.2 21.7 21.6 19.9 19.2 19.1 18.5 20.7 21.7 19.0 18.7 19.3 22.9 15.9 21.9 22.4 21.5 12.3 23.8 24.0 22.1 22.2 21.7 22.3 11.8 21.5 22.3 23.1 20.2 17.8 20.2 21.1 24.0 21.2 21.4 20.9 20.8 20.3 18.5 23.4 21.6 20.1 18.1 22.3 22.6 16.5 22.1 21.7 19.0

13 2 2 3 36 5 6 49 1 24 28 39 31 0 27 36 13 6 13 2 4 3 3 2 1 2 1 0 6 4 2 4 0 2 1 2 4 5 2 2 6 3 2 1 2 2 1 0 3 0 1

0 0 0 2 0 6 0 0 0 0 0 50 20 1 0 0 0 0 0 5 0 0 0 0 0 0 0 3 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,054.54 1,592.72 1,108.46 1,198.63 816.42 1,934.86 932.43 907.53 1,617.91 1,242.57 1,370.66 1,546.70 2,173.96 2,439.28 903.52 1,105.47 1,181.57 1,309.66 983.52 2,019.16 1,015.58 1,107.57 1,266.58 1,308.69 1,222.57 1,355.68 979.59 1,997.01 1,519.79 1,135.59 1,322.60 997.57 2,936.45 1,396.75 815.47 1,064.60 1,530.72 1,532.71 1,894.99 1,245.71 1,727.95 1,320.68 1,415.65 2,426.26 1,723.96 1,260.61 1,388.70 1,756.73 1,499.79 2,741.38 728.47

Table S1 page 138/159

Peptidyl-prolyl cis-trans isomerase FKBP3

FKBP3_HUMAN FKBP3

25,159

100.00%

6

6

18

Eukaryotic translation initiation factor 3 subunit F

EIF3F_HUMAN EIF3F

37,546

100.00%

3

3

7

Protein disulfide-isomerase

PDIA1_HUMAN P4HB

57,100

100.00%

31

40

314

30.80% AWTVEQLR FLQEHGSDSFLAEHK GWDEALLTMSK SEETLDEGPPK SEQLPK TANKDHLVTAYNHLFETK 10.90% FLMSLVNQVPK VIGLSSDLQQVGGASAR VIGTLLGTVDK 60.40% AEGSEIR EADDIVNWLK EADDIVNWLKK ENLLDFIK FFPASADR HNQLPLVIEFTEQTAPK IKPHLMSQELPEDWDKQPVK ILEFFGLK ILEFFGLKK ILFIFIDSDHTDNQR ITEFCHR KEECPAVR KFDEGR KSNFAEALAAHK LGETYKDHENIVIAK LITLEEEMTK LKAEGSEIR MDSTANEVEAVK NFEDVAFDEK NFEDVAFDEKK NNFEGEVTK NNFEGEVTKENLLDFIK QFLQAAEAIDDIPFGITSNSDVFSK

QLAPIWDK SNFAEALAAHK TGPAATTLPDGAAAESLVESSEVAVIGFFK

Protein DJ-1

PARK7_HUMAN PARK7

19,873

100.00%

11

13

65

THILLFLPK TVIDYNGER VDATEESDLAQQYGVR YKPESEELTAER YQLDKDGVVLFK 49.70% ALVILAK DGLILTSR EGPYDVVVLPGGNLGAQNLSESAAVK

EILKEQENR GAEEMETVIPVDVMR GAEEMETVIPVDVMRR KEGPYDVVVLPGGNLGAQNLSESAAVK

VEKDGLILTSR VTTHPLAK VTVAGLAGK VTVAGLAGKDPVQCSR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 95.0%

45.8 31.8 74.3 50.0 32.8 35.7 81.3 100.0 74.5 49.2 62.6 46.8 54.5 40.6 62.5 36.0 53.7 39.9 70.7 52.9 51.2 43.0 37.7 36.4 71.1 38.5 84.2 55.4 48.7 30.9 80.7 44.3 45.8 54.1 64.6 38.1 32.4 115.0 61.6 65.2 57.7 42.4 64.7 45.3 68.7 44.0 34.1 33.5 32.5 30.1 40.3

23.3 21.7 22.4 20.3 21.1 22.0 20.9 21.3 19.2 23.9 22.6 22.5 20.7 21.8 19.9 20.3 18.3 16.3 21.8 21.8 21.9 23.7 23.2 21.8 23.0 23.7 20.8 19.3 21.4 22.4 21.4 21.6 19.7 22.6 20.0 12.0 22.7 22.0 22.5 20.7 11.8 24.1 20.8 24.0 23.2 22.0 18.2 20.4 16.0 21.0 21.4

2 0 5 2 1 0 3 2 2 2 21 2 20 1 11 0 14 2 2 5 2 1 0 2 14 2 26 4 9 1 3 3 2 4 0 6 2 26 11 7 15 7 6 4 18 0 0 1 1 1 0

0 4 0 0 0 0 0 0 0 0 0 0 0 0 41 0 0 0 2 0 0 0 2 11 0 0 0 0 0 0 6 1 0 0 9 5 0 2 4 10 0 0 3 1 0 5 1 0 0 0 2

0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,002.54 1,744.83 1,250.61 1,201.56 701.38 2,102.07 1,291.71 1,657.89 1,115.67 761.38 1,202.61 1,330.70 991.55 910.44 1,965.04 2,418.25 966.57 1,094.66 1,833.91 962.45 988.49 751.37 1,286.69 1,729.91 1,222.62 1,002.56 1,309.59 1,213.54 1,341.63 1,037.49 2,010.02 2,713.34 970.54 1,158.59 2,935.49 1,081.68 1,066.52 1,780.84 1,451.70 1,424.78 727.51 874.50 2,584.33 1,158.61 1,707.79 1,863.89 2,712.42 1,230.71 866.51 815.50 1,657.87

Table S1 page 139/159

Putative hydroxypyruvate isomerase HYI_HUMAN

HYI

30,388

100.00%

4

4

7

Selenium-binding protein 1

SBP1_HUMAN SELENBP1

52,374

99.90%

2

2

3

Heterogeneous nuclear ribonucleoprotein A3

ROA3_HUMAN HNRNPA3

39,577

100.00%

3

3

17

Osteoclast-stimulating factor 1

OSTF1_HUMAN OSTF1

23,770

100.00%

3

4

7

Glycogen phosphorylase, brain form PYGB_HUMAN PYGB

96,680

100.00%

10

10

28

BGH3_HUMAN TGFBI

74,665

100.00%

21

25

175

Transforming growth factor-betainduced protein ig-h3

21.70% AEMEAVFLENLR EFLPIVGHVQVAQVPGR GDTVEGLSWLR ITDPQYFLDTPQQAAAILQK 6.57% GGPVQVLEDEELK NTGTEAPDYLATVDVDPK 10.30% EDSVKPGAHLTVK IETIEVMEDR IFVGGIK IFVGGIKEDTEEYNLR 20.10% DIVEMLFTQPNIELNQQNK GYADIVQLLLAK LGDTALHAAAWK 14.90% GLAGLGDVAEVR IGEEFLTDLSQLK IGEEFLTDLSQLKK IVNGWQVEEADDWLR LLPLVSDEVFIR LQDFNVGDYIEAVLDR LVTSIGDVVNHDPVVGDR VAIQLNDTHPALSIPELMR VIFLENYR VLYPNDNFFEGK 33.70% DGTPPIDAHTR DLLNNHILK EGVYTVFAPTNEAFR ELANILK FSMLVAAIQSAGLTETLNR GDELADSALEIFK ILGDPEALR ILGDPEALRDLLNNHILK IPSETLNR LTLLAPLNSVFK NHIIKDQLASK NNVVSVNK NNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQER

Serine/threonine-protein phosphatase 2ABA_HUMAN PPP2R2A 2A 55 kDa regulatory subunit B alpha isoform ERAP1_HUMAN ERAP1 Endoplasmic reticulum aminopeptidase 1

51,675

100.00%

3

3

6

107,220

100.00%

18

18

46

QAGLGNHLSGSER QASAFSR SPYQLVLQHSR VLTDELK VLTPPMGTVMDVLK YGTLFTMDR YLYHGQTLETLGGK YLYHGQTLETLGGKK 8.05% LFEEPEDPSNR SFFSEIISSISDVK VVIFQQEQENK 21.50% ASLINNAFQLVSIGK DMNEVETQFK EMFDDVSYDK ESALLFDAEK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

32.3 35.3 56.8 88.9 64.2 64.1 30.6 66.0 34.6 46.2 78.9 75.4 46.0 74.4 70.1 43.6 98.5 64.5 119.0 38.7 31.6 50.2 55.6 36.2 35.4 66.1 37.3 107.0 90.6 60.2 27.1 56.0 60.9 42.1 33.5 39.0 56.8 41.4 71.6 33.1 47.0 63.2 66.3 52.3 60.9 65.2 66.3 101.0 34.8 30.8 45.3

21.9 16.4 23.3 19.9 22.3 22.2 21.4 23.0 16.5 21.4 22.3 16.7 21.6 21.4 22.6 20.4 22.0 18.3 22.1 21.8 19.3 21.6 21.8 23.3 18.0 21.8 20.0 21.1 22.4 18.4 14.1 21.6 12.0 18.9 24.0 15.8 22.4 21.1 21.4 23.0 22.7 21.3 22.6 20.3 20.4 23.5 23.8 17.8 19.0 15.7 23.4

1 0 2 2 1 2 1 14 1 2 2 2 2 2 3 0 2 3 3 0 0 5 3 3 1 20 4 14 30 7 0 7 13 2 1 0 5 4 7 2 10 10 5 0 2 2 2 3 2 1 2

0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 4 1 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 4 0 8 0 0 0 6 2 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,437.70 1,846.03 1,232.63 2,261.18 1,412.73 1,905.91 1,380.75 1,234.60 733.46 1,882.96 2,274.14 1,303.76 1,253.66 1,156.63 1,492.79 1,620.89 1,829.88 1,400.82 1,866.92 1,891.99 2,134.13 1,053.57 1,442.70 1,179.58 1,079.62 1,700.83 800.49 2,038.06 1,407.70 983.55 2,044.16 929.51 1,315.80 1,266.72 873.48 4,362.26 1,325.66 766.38 1,327.71 817.47 1,532.81 1,103.52 1,579.81 1,707.91 1,332.61 1,558.80 1,361.71 1,574.89 1,256.55 1,248.51 1,122.57

Table S1 page 140/159

Histone H2A type 1-D

H2A1D_HUMAN HIST1H2AD

14,090

100.00%

2

3

21

Laminin subunit beta-3

LAMB3_HUMAN LAMB3

129,553

100.00%

31

39

345

FELGSSSIAHMVMGTTNQFSTR GFPLITITVR GTHTAVSSNDR HLAISNMPLVK ILASTQFEPTAAR NPVGYPLAWQFLR QTWTDEGSVSER SDGTPFPWNK SGIVQYLQK TDVLILPEEVEWIK TKTDVLILPEEVEWIK TQEFPQILTLIGR VGDYFFGK VSVYAVPDK 21.50% AGLQFPVGR VTIAQGGVLPNIQAVLLPK 34.70% AAEESASQIQSSAQR AGGAFLMAGQVAEQLR AHAVEGQVEDVVGNLR AVLSSPAVTEQEVAQVASAILSLR

CDCNILGSR EGFGGLMCSAAAIR GFNAQLQR GYHPPSAYYAVSQLR IQEVGEITNLR ISSADPSGAFR LEMSSLPDLTPTFNK LETQVSASR LGQSSMLGEQGAR LLIQQVR LPNVDLVLSQTK LQAEAEEAR MLSTAYEQSAQAAQQVSDSSR MNEIQAIAAR QGTVALQEAQDTMQGTSR QLGDFWTR QQGAEAVQAQQLAEGASEQALSAQEGFER

Malate dehydrogenase, cytoplasmic MDHC_HUMAN MDH1

36,409

100.00%

12

12

102

RLQAEAEEAR RVEQIR SADLTGLEK SFNGLLTMYQR TEAEELFGETMEMMDR TLQGLQLDLPLEEETLSLPR TYGDVATGCR VAEVQQVLRPAEK VENVASSSGPMR VQLNLMDLVSGIPATQSQK 43.10% AICDHVR DVIATDKEDVAFK ELTEEKESAFEFLSSA ENFSCLTR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

45.9 39.9 31.7 40.1 77.1 36.0 48.9 34.0 34.6 47.1 26.9 67.6 33.7 40.5 65.0 62.7 107.0 96.2 95.2 107.0 34.8 85.4 54.6 46.4 71.4 62.7 79.7 82.1 85.5 46.4 80.8 39.6 139.0 91.6 102.0 45.7 87.6 48.5 33.5 40.0 48.3 91.0 85.7 47.0 60.8 65.9 123.0 33.1 93.9 75.1 47.2

20.0 15.6 20.3 19.5 22.3 21.9 19.9 21.0 18.7 20.3 17.7 19.0 22.0 21.6 22.4 11.1 22.4 22.3 21.4 16.6 17.4 21.3 23.9 22.7 22.5 23.5 21.6 23.5 22.9 13.8 19.5 21.0 20.2 23.2 21.5 22.9 20.3 22.7 22.6 24.0 23.0 11.1 16.5 18.1 18.2 22.2 19.7 20.8 23.0 21.6 20.0

0 4 2 2 8 2 1 1 2 3 0 8 1 2 5 14 36 18 5 4 1 2 5 0 17 4 11 18 21 2 28 2 6 15 6 4 0 3 1 4 4 9 12 1 5 38 15 1 11 28 2

1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2 2 0 18 5 0 0 0 3 0 0 0 0 0 0 0 0 4 0 6 0 5 0 0 0 0 0 1 0 1 0 3 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

2,433.12 1,116.68 1,144.53 1,238.69 1,404.75 1,560.83 1,394.62 1,148.54 1,035.58 1,683.92 1,913.06 1,515.85 932.45 977.53 944.53 1,931.17 1,562.74 1,634.83 1,692.87 2,439.35 1,094.47 1,455.67 933.49 1,708.84 1,271.70 1,107.54 1,692.85 990.52 1,333.65 869.56 1,326.76 1,016.50 2,274.03 1,116.58 1,936.90 1,022.51 3,031.44 1,172.60 800.47 933.49 1,329.66 1,950.78 2,265.23 1,099.48 1,466.83 1,249.58 2,058.09 870.43 1,450.74 1,816.85 1,026.47

Table S1 page 141/159

Annexin A5

ANXA5_HUMAN ANXA5

35,921

100.00%

25

34

482

EVGVYEALKDDSWLK FVEGLPINDFSR GEFVTTVQQR LGVTANDVK LSSAMSAAK NVIIWGNHSSTQYPDVNHAK SQGAALDK VIVVGNPANTNCLTASK 75.90% ADAETLR ADAETLRK DLLDDLKSELTGK DPDAGIDEAQVEQDAQALFQAGELK

ETSGNLEQLLLAVVK FITIFGTR GAGTDDHTLIR GLGTDEESILTLLTSR GTVTDFPGFDER GTVTDFPGFDERADAETLR KNFATSLYSMIK LIVALMKPSR LYDAYELK MLVVLLQANR NFATSLYSMIK QEISAAFK QVYEEEYGSSLEDDVVGDTSGYYQR

GDP-L-fucose synthase

FCL_HUMAN TSTA3

35,875

99.50%

2

2

10

9.35%

Ran-specific GTPase-activating protein

RANG_HUMAN RANBP1

23,293

100.00%

3

3

9

16.40%

Ephrin type-A receptor 2

EPHA2_HUMAN EPHA2

108,249

100.00%

4

4

8

4.30%

162,232

99.50%

2

2

2

1.95%

35,062

99.50%

2

2

4

9.77%

27,530

100.00%

8

8

19

49.20%

CAP-Gly domain-containing linker CLIP1_HUMAN CLIP1 protein 1 Serine/threonine-protein phosphatase PP4C_HUMAN PPP4C 4 catalytic subunit 6PGL_HUMAN PGLS 6-phosphogluconolactonase

SEIDLFNIR SEIDLFNIRK SIPAYLAETLYYAMK TPEELR VLTEIIASR WGTDEEK WGTDEEKFITIFGTR YMTISGFQIEETIDR DADLTDTAQTR VVADGAGLPGEDWVFVSSK FASENDLPEWK TLEEDEEELFK VAEKLEALSVK FADIVSILDK LNVEER VLEDDPEATYTTSGGK YSEPPHGLTR LTNLQENLSEVSQVK SQQLSALQEENVK EILVEESNVQR VGGDVPETNYLFMGDFVDR ELPAAVAPAGPASLAR ILEDQEENPLPAALVQPHTGK IVAPISDSPKPPPQR LCWFLDEAAAR LPIPESQVITINPELPVEEAAEDYAK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

74.4 63.8 76.5 61.6 39.1 50.0 34.8 133.0 42.8 48.4 86.8 89.2 110.0 54.0 84.3 126.0 64.6 45.4 56.8 65.3 53.3 38.8 69.9 47.2 36.5 68.2 38.8 80.6 40.6 78.8 30.9 78.2 56.9 78.7 32.2 57.4 49.3 29.3 50.8 34.7 52.7 27.0 47.7 51.8 37.7 70.8 43.7 62.6 59.0 56.5 28.7

21.1 22.9 23.3 23.0 21.6 22.0 24.9 21.5 24.0 23.2 22.9 20.5 19.2 19.7 22.0 22.1 21.2 21.9 22.7 15.6 21.1 20.1 22.0 22.0 17.2 23.7 21.3 22.7 20.7 19.8 17.6 22.1 22.0 20.7 22.0 21.4 21.3 17.4 21.7 23.4 20.9 22.0 21.5 21.8 22.9 20.9 19.6 20.6 18.2 22.3 19.7

8 12 12 15 1 0 1 4 2 6 24 2 29 10 20 30 44 0 5 5 13 2 62 13 1 64 3 25 1 38 1 19 3 9 1 2 6 0 4 2 1 0 1 1 2 2 3 0 2 1 0

0 0 0 0 0 7 0 0 0 0 1 4 1 0 1 5 0 3 1 13 0 0 0 0 0 0 0 3 0 0 0 28 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 2 0 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,751.89 1,393.71 1,164.60 916.51 881.44 2,280.12 789.41 1,757.92 775.40 903.49 1,446.77 2,658.25 1,613.91 954.54 1,155.58 1,704.90 1,340.61 2,096.99 1,402.74 1,127.70 1,014.51 1,172.68 1,290.64 893.47 2,888.24 1,106.58 1,234.68 1,749.88 744.39 1,001.60 864.37 1,799.90 1,818.86 1,206.56 1,932.97 1,335.62 1,381.64 1,186.70 1,120.63 759.40 1,682.78 1,156.58 1,701.90 1,473.76 1,315.69 2,130.98 1,490.83 2,299.19 1,601.90 1,351.65 2,865.48

Table S1 page 142/159

Small nuclear ribonucleoprotein Sm SMD3_HUMAN SNRPD3 D3 HNRH1_HUMAN HNRNPH1 Heterogeneous nuclear ribonucleoprotein H

13,899

99.50%

2

2

4

15.10%

49,212

100.00%

6

9

90

18.70%

SERA_HUMAN PHGDH

56,633

99.50%

2

2

2

3.19%

GLOD4_HUMAN GLOD4

34,776

100.00%

6

7

20

22.00%

Isoleucyl-tRNA synthetase, cytoplasmic

SYIC_HUMAN IARS

144,484

100.00%

3

3

4

2.06%

Myosin-Ic

MYO1C_HUMAN MYO1C

121,709

100.00%

2

2

2

3.29%

Interleukin-18

IL18_HUMAN IL18

22,309

100.00%

2

2

6

8.81%

Calsyntenin-1

CSTN1_HUMAN CLSTN1

109,774

100.00%

30

36

929

28.70%

D-3-phosphoglycerate dehydrogenase Glyoxalase domain-containing protein 4

LVPFDHAESTYGLYR TVIFVATGEGK VTLTLPVLNAAR FLILPDMLK VAQLEQVYIR ATENDIYNFFSPLNPVR GLPWSCSADEVQR HTGPNSPDTANDGFVR SNNVEMDWVLK STGEAFVQFASQEIAEK VHIEIGPDGR DLPLLLFR TLGILGLGR ELPDLEDLMK GGVDHAAAFGR ILTPLVSLDTPGK IYEKDEEK LLDDAMAADKSDEWFAK VTLAVSDLQK FLIQNVLR LESDYEILER LLILMEAR GEELLSPLNLEQAAYAR VLQALGSEPIQYAVPVVK SDIIFFQR TIFIISMYK AASEFESSEGVFLFPELR AMQHISYLNSR ATEDVLVK ATVHIQVNDVNEYAPVFK ATVIEGK EGLDLQVLEDSGR EKLDCELQK EPFTISVWMR ETILCSSDK ETILCSSDKTDMNR GNLAGLTLR GPDGTNVK GPDGTNVKK GVQIQAHPSQLVLTLEGEDLGELDK

IHGQNVPFDAVVVDK IISTITR IPDGVVSVSPK IPDGVVSVSPKEPFTISVWMR ISIKPTCTPGWQGWNNR ISLSGVHHFAR LDCELQK LIFLFR LTVTAYDCGK QFPTPGIR QYDSILR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

35.5 47.7 68.2 31.4 75.2 74.0 34.1 97.0 40.3 104.0 44.3 41.0 30.7 46.2 55.9 60.9 31.1 33.1 53.3 33.8 34.5 41.6 34.5 47.5 51.8 37.1 85.6 75.3 65.0 78.9 44.9 108.0 32.4 42.3 36.5 65.2 67.2 61.1 36.8 64.9 101.0 55.9 74.8 46.4 42.5 78.3 37.1 44.1 49.2 44.6 51.9

22.5 22.0 12.6 19.8 22.7 22.4 20.8 20.9 21.6 22.0 22.2 19.3 18.9 21.8 21.5 15.6 22.7 20.4 21.0 16.9 22.8 20.4 22.0 15.6 21.9 22.6 22.3 23.0 23.6 21.9 25.5 22.2 23.9 22.2 21.2 19.8 20.8 20.0 21.6 19.8 21.5 17.9 19.4 21.3 22.2 21.0 22.4 12.8 22.3 23.1 22.4

2 2 6 3 1 23 1 12 1 36 3 1 1 2 4 8 1 0 3 2 1 1 1 1 3 3 188 21 20 25 16 124 1 16 1 2 80 4 3 0 35 44 98 0 1 6 6 17 8 7 17

0 0 0 0 0 1 0 12 0 0 1 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 2 14 0 50 0 0 0 0 0 0 0 0 0 20 28 0 0 2 11 16 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,767.87 1,121.62 1,267.77 1,089.64 1,218.68 1,996.98 1,504.69 1,684.77 1,350.64 1,841.89 1,092.58 986.60 899.57 1,202.60 1,057.52 1,353.80 1,053.51 1,941.89 1,073.62 1,002.61 1,266.62 974.57 1,873.97 1,911.10 1,025.54 1,131.61 2,014.98 1,319.65 874.49 2,044.05 717.41 1,430.71 1,162.58 1,281.63 1,052.49 1,685.75 914.54 787.40 915.49 2,689.41 1,637.87 803.50 1,097.62 2,360.23 2,014.99 1,223.66 905.44 808.51 1,127.54 915.51 894.47

Table S1 page 143/159

SLLDRK STGEGVIR VIDCLYTCK YISNEFK YRPAEFHWK TEESPASDEAGEKEAK VSSAEGAAKEEPK EQFVEFR TFDQLTPEESK WIYEDVER AAGDVDIGDAAYYFER DIKGESLFQGR TLIYYLDEIPPK GAMGPAGPDGHQGPR GEQGLTGMPGIR LLSTDASHSR LQGMAPAAGADLDK SELISYLTSPDVR DRPFFAGLVK FMQASEDLLK GDFCIQVGR GLVGEIIK GLVGEIIKR NIIHGSDSVESAEK TFIAIKPDGVQR VMLGETNPADSKPGTIR YMHSGPVVAMVWEGLNVVK AAHSEGNTTAGLDMR DASLMVTNDGATILK EAVAMESYAK GATQQILDEAER IGVNQPK ILIANTGMDTDKIK LGGSLADSYLDEGFLLDK LGGSLADSYLDEGFLLDKK LKGSGNLEAIHIIK SLHDALCVLAQTVK

Non-histone chromosomal protein HMG-14 Calumenin

HMGN1_HUMAN HMGN1

10,641

99.50%

2

2

4

29.00%

CALU_HUMAN CALU

37,090

100.00%

3

3

5

8.25%

Tumor-associated calcium signal transducer 2

TACD2_HUMAN TACSTD2

35,692

100.00%

3

3

13

12.10%

Collagen alpha-1(XVII) chain

COHA1_HUMAN COL17A1

150,404

100.00%

5

7

22

4.28%

Nucleoside diphosphate kinase A

NDKA_HUMAN NME1

17,131

100.00%

4

6

9

65.80%

T-complex protein 1 subunit beta

TCPB_HUMAN CCT2

57,472

100.00%

11

12

21

26.50%

Peptidyl-prolyl cis-trans isomerase H PPIH_HUMAN PPIH

19,190

100.00%

3

4

10

Ubiquitin-conjugating enzyme E2 L3 UB2L3_HUMAN UBE2L3

17,844

99.50%

2

3

8

Polypyrimidine tract-binding protein PTBP1_HUMAN PTBP1 1

57,205

100.00%

7

8

24

13.00% IENVPTGPNNKPK IIDGLLVMR KIENVPTGPNNKPK 24.00% IEINFPAEYPFKPPK TDQVIQSLIALVNDPQPEHPLR 20.00% DYGNSPLHR HQNVQLPR IAIPGLAGAGNSVLLVSNLNPER

VQDDEVGDGTTSVTVLAAELLR

NFQNIFPPSATLHLSNIPPSVSEEDLK

Nicotinamide

NAMPT_HUMAN NAMPT

55,505

100.00%

3

3

9

NNQFQALLQYADPVSAQHAK VLFSSNGGVVK VTNLLMLK 8.55% AVPEGFVIPR

95.0% 95.0% 95.0% 95.0% 94.6% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

32.3 53.5 64.3 35.7 26.2 26.5 70.8 33.2 33.0 33.1 99.6 30.1 39.4 73.6 41.9 55.3 60.0 44.1 47.4 61.9 51.1 36.3 52.3 73.1 34.9 88.7 45.3 40.3 43.9 44.8 86.1 32.4 44.7 85.8 38.9 18.6 31.2 141.0 29.8 55.0 63.0 32.4 92.6 31.7 43.5 144.0 29.3 51.2 48.2 47.7 33.9

23.2 24.3 21.1 20.2 23.6 19.9 22.5 21.2 22.4 21.6 20.0 23.3 20.6 20.2 23.3 21.8 22.3 22.6 20.3 22.9 22.8 16.7 16.7 21.9 19.8 22.3 21.4 18.6 22.2 20.5 22.1 20.0 21.6 22.6 22.0 14.3 20.8 21.9 21.1 19.9 19.5 21.4 19.2 21.7 21.4 14.0 20.6 21.6 21.1 19.5 19.5

3 16 24 2 0 0 3 1 2 2 9 2 2 2 2 5 4 2 2 2 4 2 5 2 2 4 0 0 1 4 2 1 1 2 0 0 1 2 0 4 2 0 2 2 2 7 0 0 2 2 1

0 0 0 0 1 1 0 0 0 0 0 0 0 3 0 4 0 0 1 0 0 0 0 1 0 8 1 2 0 0 0 0 0 0 2 0 0 2 2 0 2 1 5 0 0 2 1 6 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

731.44 818.44 1,171.55 900.45 1,233.62 1,677.75 1,302.65 954.47 1,294.62 1,109.53 1,732.78 1,249.65 1,464.80 1,420.64 1,231.61 1,086.55 1,373.67 1,479.77 1,149.64 1,181.59 1,051.50 828.52 984.62 1,485.72 1,344.76 1,785.92 2,116.07 1,546.69 1,564.79 1,114.51 1,330.66 755.44 1,548.83 1,912.95 2,041.05 1,492.89 1,554.83 2,288.16 1,407.76 1,029.61 1,535.85 1,789.95 2,483.33 1,058.50 991.54 2,275.28 2,994.52 2,243.12 1,106.62 931.57 1,084.62

Table S1 page 144/159

phosphoribosyltransferase Probable aminopeptidase NPEPL1

PEPL1_HUMAN NPEPL1

55,843

99.50%

2

2

6

Glucose-6-phosphate 1dehydrogenase

G6PD_HUMAN G6PD

59,240

100.00%

18

22

114

Eukaryotic translation initiation factor 2 subunit 1

IF2A_HUMAN EIF2S1

36,095

100.00%

7

7

15

Proteasome subunit alpha type-7

PSA7_HUMAN PSMA7

27,869

100.00%

12

15

93

GTDTVAGLALIK VIQGDGVDINTLQEIVEGMK 5.16% ELGIIPTIIRDEELK TVEINNTDAEGR 41.20% CISEVQANNVVLGQYVGNPDGEGEATK DGLLPENTFIVGYAR EMVQNLMVLR GGYFDEFGIIR GPTEADELMK GPTEADELMKR GYLDDPTVPR IFGPIWNR IIVEKPFGR KPGMFFNPEESELDLTYGNR LFYLALPPTVYEAVTK LKLEDFFAR LNSHMNALHLGSQANR LPDAYER LSNHISSLFR NSYVAGQYDDAASYQR QSEPFFK VGFQYEGTYK 23.80% AGLNCSTENMPIK GVFNVQMEPK INLIAPPR LTPQAVK TEGLSVLSQAMAVIK VVTDTDETELAR YVMTTTTLER 45.60% AITVFSPDGHLFQVEYAQEAVK AITVFSPDGHLFQVEYAQEAVKK

Semaphorin-7A

SEM7A_HUMAN SEMA7A

74,806

100.00%

5

5

21

Density-regulated protein

DENR_HUMAN DENR

22,074

100.00%

4

4

11

ADP-ribose pyrophosphatase,

NUDT9_HUMAN NUDT9

39,108

99.50%

2

2

2

ALLEVVQSGGK DIVVLGVEK GRDIVVLGVEK GSTAVGVR ILNPEEIEK KGSTAVGVR LTVEDPVTVEYITR LYQTDPSGTYHAWK NIELAVMR NYTDEAIETDDLTIK 8.86% AAAIQTMSLDAER GDQGGESSLSVSK LQDVFLLPDPSGQWR VSLAPNSR VYLFDFPEGK 21.70% LDADYPLR QEAGISEGQGTAGEEEEK WPEVDDDSIEDLGEVK WPEVDDDSIEDLGEVKK 7.43% EFGEEALNSLQK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

59.0 126.0 34.5 59.6 70.8 79.2 64.1 54.9 40.2 51.0 45.3 41.0 34.0 43.0 48.6 43.6 61.4 45.2 33.4 98.6 33.2 37.1 42.6 38.4 45.0 33.3 37.7 78.6 30.2 56.5 35.1 81.3 45.2 63.9 37.6 34.7 43.8 102.0 70.9 40.2 136.0 61.3 66.7 51.4 32.3 55.8 46.0 82.1 95.8 42.7 40.9

21.6 20.7 15.6 21.7 20.9 22.8 22.9 21.8 21.9 22.9 23.1 24.8 18.6 19.3 17.6 20.3 22.6 24.0 23.7 19.3 21.5 22.9 19.7 23.2 13.0 15.4 20.3 23.8 22.2 21.7 20.7 22.7 19.8 19.2 24.2 20.8 21.7 22.1 21.8 24.5 21.2 22.1 22.9 22.5 22.6 22.2 23.6 18.8 20.5 21.5 22.7

2 6 1 5 0 11 8 9 3 4 5 6 2 0 7 7 1 5 1 19 2 3 2 2 2 1 1 6 1 2 0 12 2 6 1 3 1 17 4 4 31 3 6 4 3 5 4 3 2 0 1

0 0 0 0 2 0 0 0 0 0 0 0 0 4 0 10 1 0 2 0 0 0 0 0 0 0 0 0 0 5 2 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 0 2 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,158.67 2,158.11 1,739.00 1,318.62 2,848.34 1,664.87 1,232.65 1,273.62 1,106.50 1,262.61 1,132.56 1,002.55 1,058.64 2,360.09 1,825.02 1,138.63 1,778.87 863.43 1,173.64 1,807.79 882.44 1,191.57 1,450.67 1,164.57 893.56 756.46 1,546.85 1,348.66 1,214.61 2,449.24 2,577.34 1,100.63 971.58 1,184.70 746.42 1,084.59 874.51 1,634.86 1,666.79 945.52 1,740.82 1,392.68 1,250.59 1,770.92 843.47 1,214.61 962.49 1,848.81 1,845.84 1,973.93 1,364.67

Table S1 page 145/159

mitochondrial Glycogen debranching enzyme

GDE_HUMAN AGL

174,750

100.00%

11

11

19

High mobility group protein B2

HMGB2_HUMAN HMGB2

24,017

100.00%

8

11

42

Phosphatidylethanolamine-binding protein 1

PEBP1_HUMAN PEBP1

21,039

100.00%

8

9

55

WADPQISESNFSPK 8.88% AVTVYTNYPFPGETFNR FPSLPILSPALMDVPYR IPFASLASR LEQGYELQFR LGISSLIR LGPTLQGK LTLAELNQILYR SDPNQHLTIIQDPEYR SGGGYIVVDPILR SGSLAVDNADPILK YTWNDVGQLVEK 33.00% HPDSSVNFAEFSK IKSEHPGLSIGDTAK KLGEMWSEQSAK LGEMWSEQSAK MSSYAFFVQTCR SEHPGLSIGDTAK SKFEDMAK YEKDIAAYR 59.40% GNDISSGTVLSDYVGSGPPK LYEQLSGK LYTLVLTDPDAPSR LYTLVLTDPDAPSRK NRPTSISWDGLDSGK VLTPTQVK WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK

Protein FAM49B

FA49B_HUMAN FAM49B

Uncharacterized glycosyltransferase AER61_HUMAN AER61 AER61

36,731

100.00%

11

13

37

61,994

100.00%

3

3

5

32,931

100.00%

3

3

10

F-actin-capping protein subunit alpha-2

CAZA2_HUMAN CAPZA2

60S ribosomal protein L7

RL7_HUMAN

RPL7

29,210

100.00%

2

2

4

Leucyl-tRNA synthetase, cytoplasmic

SYLC_HUMAN LARS

134,453

99.50%

2

2

3

YVWLVYEQDRPLK 42.00% AWGAVVPLVGK DAEGILEDLQSYR DQPPNSVEGLLNALR EAIQHPADEK EAIQHPADEKLQEK GLLGALTSTPYSPTQHLER HLNDETTSK INNVPAEGENEVNNELANR MSLFYAEATPMLK MTNPAIQNDFSYYR VMLETPEYR 5.69% EAVFSLLPR ELGFLDQLR ILNQNELVNALK 27.60% EGAAHAFAQYNLDQFTPVK FIIHAPPGEFNEVFNDVR FTITPSTTQVVGILK IQVHYYEDGNVQLVSHK LLLNNDNLLR 10.10% IALTDNALIAR IVEPYIAWGYPNLK 1.96% FDDPLLGPR STGNFLTLTQAIDK

95.0% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 94.8% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

48.9 68.9 44.0 31.6 30.2 43.2 30.9 49.8 26.4 64.2 64.4 59.1 36.0 62.0 47.2 65.6 104.0 47.2 32.1 50.4 121.0 58.7 97.2 64.7 79.3 30.4 26.1 38.1 48.5 84.7 81.7 39.8 74.0 59.2 45.4 94.3 65.6 99.5 40.3 65.3 44.9 45.6 36.8 36.6 78.8 40.7 72.5 70.4 55.3 35.2 61.7

22.0 21.2 19.8 21.2 21.9 20.1 17.9 17.5 21.6 20.8 21.5 22.4 21.1 21.0 22.2 20.6 19.7 22.5 20.0 22.0 22.7 20.9 22.5 20.2 22.9 17.2 19.2 21.3 17.6 22.3 21.5 23.2 22.8 21.3 19.7 21.6 22.7 21.5 23.0 20.8 23.2 17.6 22.3 21.8 14.1 22.2 19.2 20.1 20.3 22.0 21.7

1 2 1 1 1 2 1 2 0 3 3 2 1 2 2 2 19 5 1 5 14 12 13 0 6 1 0 1 3 4 6 1 2 2 1 2 5 4 3 2 2 1 0 0 6 0 14 2 2 1 2

0 0 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 1 0 2 0 0 0 3 3 0 0 0 0 0 0 0 2 2 0 0 0 0 0 0 0 0 2 2 0 11 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,605.76 1,975.96 1,932.03 961.55 1,282.64 858.54 813.48 1,446.83 1,925.94 1,345.75 1,399.74 1,451.72 1,464.68 1,552.83 1,409.67 1,265.58 1,512.66 1,311.65 955.46 1,128.57 1,949.95 937.50 1,560.83 1,688.92 1,632.80 885.54 3,471.72 1,708.91 1,096.65 1,508.72 1,622.85 1,137.55 1,635.83 2,041.07 1,044.50 2,096.00 1,533.73 1,735.78 1,137.56 1,031.59 1,090.59 1,368.79 2,107.03 2,101.05 1,604.93 2,029.01 1,197.70 1,170.68 1,662.89 1,029.54 1,508.80

Table S1 page 146/159

Semaphorin-5A

SEM5A_HUMAN SEMA5A

120,597

100.00%

2

2

4

Metalloproteinase inhibitor 2

TIMP2_HUMAN TIMP2

24,382

100.00%

7

9

36

Glyceraldehyde-3-phosphate dehydrogenase

G3P_HUMAN

36,035

100.00%

14

19

204

GAPDH

2.42% LADPNLLEVGR NAVDFSQLTFDPGQK 25.90% AVSEKEVDSGNDIYGNPIK EVDSGNDIYGNPIK EVDSGNDIYGNPIKR EYLIAGK GAAPPKQEFLDIEDP IQYEIK SDGSCAWYR 51.90% AGAHLQGGAK GALQNIIPASTGAAK IISNASCTTNCLAPLAK LISWYDNEFGYSNR LTGMAFR LVINGNPITIFQER LVINGNPITIFQERDPSK RVIISAPSADAPMFVMGVNHEK VIHDNFGIVEGLMTTVHAITATQK

T-complex protein 1 subunit eta

TCPH_HUMAN CCT7

59,350

100.00%

14

15

37

VIISAPSADAPMFVMGVNHEK VPTANVSVVDLTCR VVDLMAHMASK VVDLMAHMASKE WGDAGAEYVVESTGVFTTMEK 37.00% ALEIIPR EGTDSSQGIPQLVSNISACQVIAEAVR

Eukaryotic translation initiation factor 3 subunit D

EIF3D_HUMAN EIF3D

63,956

100.00%

3

4

8

Ras GTPase-activating proteinbinding protein 2 GMP synthase [glutaminehydrolyzing]

G3BP2_HUMAN G3BP2

54,102

99.50%

2

2

3

GUAA_HUMAN GMPS

76,699

100.00%

4

4

7

Rho GDP-dissociation inhibitor 1

GDIR1_HUMAN ARHGDIA

23,190

100.00%

3

5

28

Uridine diphosphate glucose pyrophosphatase

NUD14_HUMAN NUDT14

24,100

100.00%

4

4

6

GGAEQFMEETER LLDVVHPAAK LPIGDVATQYFADR MVVDAVMMLDDLLQLK QLCDNAGFDATNILNK QVKPYVEEGLHPQIIIR SLHDAIMIVR SQDAEVGDGTTSVTLLAAEFLK STVDAPTAAGR TATQLAVNK TFSYAGFEMQPK VQGGALEDSQLVAGVAFK 8.94% IFHTVTTTDDPVIR LGDDIDLIVR YNFPNPNPFVEDDMDKNEIASVAYR

6.22% LPNFGFVVFDDSEPVQR VEAKPEVQSQPPR 7.94% ELGLPEELVSR EPPTDVTPTFLTTGVLSTLR SGNIVAGIANESK TLNMTTSPEEK 22.10% AEEYEFLTPVEEAPK IDKTDYMVGSYGPR SIQEIQELDKDDESLR 21.60% IEGASVGR QFRPAVYAGEVER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.7% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

54.9 69.2 103.0 80.1 91.5 34.0 48.1 40.9 35.0 69.1 95.3 93.8 97.8 46.0 86.9 62.0 47.1 45.6 90.5 119.0 47.8 61.5 133.0 43.5 32.8 63.8 39.3 96.5 73.3 57.9 18.5 30.0 135.0 56.2 44.0 68.7 51.0 57.5 75.9 45.1 33.3 33.4 43.2 88.5 46.8 37.2 82.3 83.1 90.4 34.7 31.5

19.9 22.4 22.8 22.6 22.2 21.8 22.6 21.8 15.4 21.2 20.5 22.3 21.3 22.0 20.6 18.6 21.7 20.2 21.7 22.9 22.7 22.5 20.1 15.4 20.6 16.7 17.0 22.8 21.5 23.1 14.3 21.3 22.4 21.6 22.8 19.4 21.5 21.9 21.7 19.0 22.2 21.3 20.9 19.6 23.2 22.6 22.6 22.3 22.2 24.3 22.3

2 2 2 3 10 5 7 4 1 15 25 4 6 8 22 2 0 0 6 20 2 18 21 2 0 6 2 2 4 2 0 1 5 5 2 2 1 2 2 0 1 0 1 2 1 3 19 2 2 1 0

0 0 2 0 2 0 0 0 0 0 0 0 0 0 0 1 4 13 2 2 0 0 12 0 1 0 0 0 0 0 0 0 1 0 0 0 0 2 0 2 0 2 0 0 0 0 0 4 1 0 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,196.66 1,666.81 2,035.00 1,520.72 1,676.82 793.45 1,626.80 793.45 1,101.44 909.49 1,411.79 1,833.92 1,763.80 811.41 1,613.90 2,041.11 2,401.20 2,611.36 2,213.11 1,530.80 1,201.61 1,330.65 2,293.03 811.50 2,829.41 1,399.58 1,062.63 1,565.80 1,881.94 1,793.85 2,019.14 1,170.63 2,252.13 1,045.53 945.54 1,421.64 1,788.95 1,614.85 1,128.63 2,961.34 1,965.97 1,464.78 1,241.67 2,145.14 1,259.66 1,266.59 1,751.84 1,601.76 1,917.94 788.43 1,521.78

Table S1 page 147/159

Malignant T cell-amplified sequence MCTS1_HUMAN MCTS1 1

Interleukin-1 receptor antagonist protein Serpin B3

20,538

100.00%

4

6

7

31.50%

IL1RA_HUMAN IL1RN

20,037

99.90%

2

2

4

19.20%

SPB3_HUMAN SERPINB3

44,548

100.00%

8

9

22

25.10%

37,496

100.00%

6

6

11

19.70%

106,795

100.00%

9

9

15

13.10%

41,463

100.00%

2

2

3

7.25%

99,349

99.50%

2

2

3

3.41%

72,355

100.00%

3

3

7

6.00%

38,850

100.00%

4

4

18

19.80%

Serine/threonine-protein phosphatase PP1A_HUMAN PPP1CA PP1-alpha catalytic subunit

Alanyl-tRNA synthetase, cytoplasmic

SYAC_HUMAN AARS

ADH7_HUMAN ADH7 Alcohol dehydrogenase class 4 mu/sigma chain Pyruvate dehydrogenase phosphatase PDPR_HUMAN PDPR regulatory subunit, mitochondrial DDX17_HUMAN DDX17 Probable ATP-dependent RNA helicase DDX17

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

NHRF1_HUMAN SLC9A3R1

Phosphoglucomutase-1

PGM1_HUMAN PGM1

61,433

100.00%

22

27

112

QTMFYTEVTDAQR VATYWSGVGLTGSR LYPAAVDTIVAIMAEGK MSAEDIEK NQLIEQFPGIEPWLNQIMPK YPFILPHQQVDK LQLEAVNITDLSENR NNQLVAGYLQGPNVNLEEK DLSMIVLLPNEIDGLQK DNTAQQIK FYQTSVESVDFANAPEESR GLVLSGVLHK INSWVESQTNEK LMEWTSLQNMR VDLHLPR VLHFDQVTENTTGK EIFLSQPILLELEAPLK IKYPENFFLLR LNLDSIIGR NVQLTENEIR TFTDCFNCLPIAAIVDEK YPENFFLLR ASEWVQQVSGLMDGK AVFDETYPDPVR EIADLGEALATAVIPQWQK GLEVTDDSPK IVAVTGAEAQK MALELLTQEFGIPIER MSNYDTDLFVPYFEAIQK QIWQNLGLDDTK VGAEDADGIDMAYR ISEGFELLNSGQSIR MLTYDPMLLFTGR INAGLNVIGIPSEIISPK TGSIFLAQTQDR APILIATDVASR ELAQQVQQVADDYGK VLEEANQAINPK AQEAPGQAEPPAAAEVQGAGNENEPR

EALAEAALESPRPALVR LLVVDPETDEQLQK SVDPDSPAEASGLR 46.60% ADNFEYSDPVDGSISR DLEALMFDR EAIQLIAR FFGNLMDASK FNISNGGPAPEAITDK IAAANGIGR IALYETPTGWK IDAMHGVVGPYVK INQDPQVMLAPLISIALK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

54.0 79.5 82.7 32.0 50.0 34.0 67.1 109.0 57.2 53.8 93.2 48.7 73.8 54.2 49.4 68.3 56.9 31.7 47.5 39.4 74.1 55.5 41.4 47.0 53.0 38.0 40.7 37.4 42.6 31.2 72.0 87.8 53.2 36.1 51.3 57.3 53.1 52.7 75.9 35.6 68.0 51.7 108.0 48.1 45.7 60.0 104.0 47.2 31.5 46.1 97.5

19.2 22.2 20.9 20.3 20.3 21.1 22.2 21.6 19.3 23.3 19.8 12.3 21.6 22.4 20.0 22.9 13.6 18.6 20.9 23.7 21.4 21.1 22.6 22.0 18.8 23.0 21.2 21.2 20.3 22.4 19.2 22.6 22.6 12.8 22.8 18.5 22.9 21.3 21.0 19.1 21.1 21.7 18.2 21.8 19.3 20.5 22.5 20.0 22.7 22.5 16.3

2 2 2 1 1 1 2 2 4 1 2 2 2 5 3 2 3 0 2 1 2 2 1 2 2 2 2 2 1 1 2 2 1 1 2 5 1 1 0 0 9 6 5 7 2 4 2 2 1 2 20

0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 2 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,605.72 1,453.74 1,761.95 938.41 2,411.24 1,484.79 1,714.90 2,100.07 1,898.03 917.47 2,175.98 1,022.64 1,434.69 1,408.67 849.49 1,588.80 1,953.13 1,439.81 1,000.58 1,215.63 2,113.99 1,198.63 1,634.79 1,408.68 2,053.10 1,060.52 1,086.62 1,875.99 2,197.02 1,430.73 1,498.65 1,649.85 1,573.78 1,835.06 1,336.69 1,226.71 1,691.82 1,325.71 2,588.20 1,792.99 1,626.86 1,400.67 1,771.78 1,109.53 913.55 1,129.54 1,630.81 842.48 1,278.67 1,385.73 1,980.12

Table S1 page 148/159

LSGTGSAGATIR LVIGQNGILSTPAVSCIIR LYIDSYEKDVAK QEATLVVGGDGR QFSANDK QFSANDKVYTVEK SGEHDFGAAFDGDGDRNMILGK

Kallikrein-11

KLK11_HUMAN KLK11

31,041

100.00%

2

2

18

7.45%

Basic leucine zipper and W2 domain-containing protein 2 26S protease regulatory subunit 6A

BZW2_HUMAN BZW2

48,146

99.50%

2

2

6

6.68%

PRS6A_HUMAN PSMC3

49,187

100.00%

4

4

5

13.70%

Cadherin-1

CADH1_HUMAN CDH1

97,440

100.00%

14

16

158

18.40%

Cystatin-B

CYTB_HUMAN CSTB

11,121

100.00%

3

3

12

45.90%

Splicing factor, proline- and glutamine-rich

SFPQ_HUMAN SFPQ

76,132

100.00%

4

4

6

6.65%

Beta-hexosaminidase subunit alpha

HEXA_HUMAN HEXA

60,672

100.00%

11

12

70

25.10%

SIFDFSALK SMPTSGALDR TQAYQDQKPGTSGLR VDLGVLGK VSQLQER YDYEEVEAEGANK LLCGATLIAPR YVDWIQETMK DTLVQGLNEAGDDLEAVAK LLELFPVNR LAGPQLVQMFIGDGAK QTYFLPVIGLVDAEK TMLELLNQLDGFQPNTQVK VDILDPALLR DTANWLEINPDTGAISTR FKVGTDGVITVK GLDFEAK GQVPENEANVVITTLK MALEVGDYK NDVAPTLMSVPR NMFTINR NTGVISVVTTGLDR TAYFSLDTR VFYSITGQGADTPPVGVFIIER VGTDGVITVK VNFEDCTGR VTEPLDR YLPRPANPDEIGNFIDENLK SQVVAGTNYFIK VFQSLPHENKPLTLSNYQTNK VHVGDEDFVHLR FATHAAALSVR LFVGNLPADITEDEFK LFVGNLPADITEDEFKR MGGGGAMNMGDPYGSGGQK ALLSAPWYLNR DFYVVEPLAFEGTPEQK DLLFGSGSWPRPYLTGK EDIPVNYMK GLETFSQLVWK GSYNPVTHIYTAQDVK GYVVWQEVFDNK IQPDTIIQVWR LTSDLTFAYER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.9% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

81.2 47.1 73.0 84.8 41.8 28.0 33.2 39.5 31.6 69.5 50.7 55.2 112.0 85.1 52.6 123.0 53.4 34.6 60.1 64.5 32.9 120.0 52.7 41.4 97.7 64.9 34.7 30.6 121.0 71.1 115.0 80.0 60.1 34.0 30.2 53.9 81.3 63.5 42.2 66.3 28.8 30.3 57.9 72.9 36.6 30.5 50.5 69.2 54.2 50.4 83.6

23.2 15.8 22.5 22.5 22.1 22.5 18.8 20.7 21.4 23.0 20.0 23.4 16.8 20.6 20.8 21.7 20.4 21.7 19.1 21.4 13.8 22.2 17.4 23.6 20.3 21.1 22.3 21.9 20.8 21.2 20.2 21.7 17.8 21.0 21.4 21.1 20.6 22.6 23.3 22.7 22.0 10.0 22.2 21.8 21.7 22.0 21.0 22.5 22.1 19.0 22.1

23 2 2 8 2 0 0 1 1 3 4 2 6 9 9 3 3 1 2 1 1 41 2 2 31 9 2 2 10 4 14 5 3 4 0 4 2 0 0 2 0 1 12 19 1 1 7 4 2 8 4

0 0 1 0 0 1 2 0 0 4 0 0 0 0 0 0 0 0 0 0 0 0 26 0 2 0 0 0 0 0 0 0 0 0 1 0 0 6 2 0 1 0 0 0 0 0 0 1 0 0 0

0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,090.59 2,011.14 1,443.74 1,201.62 809.38 1,528.76 2,325.02 1,027.55 1,050.49 1,649.83 800.49 859.46 1,516.64 1,184.68 1,328.62 1,957.97 1,100.65 1,660.87 1,692.92 2,205.12 1,124.67 1,973.96 1,263.73 779.39 1,711.92 1,025.50 1,299.67 895.45 1,431.78 1,073.53 2,366.24 988.57 1,097.47 829.44 2,315.17 1,326.71 2,458.27 1,422.71 1,143.63 1,807.91 1,964.01 1,819.71 1,303.72 1,968.96 1,893.99 1,124.53 1,307.70 1,792.89 1,483.72 1,368.76 1,315.65

Table S1 page 149/159

NAD(P)H dehydrogenase [quinone] NQO1_HUMAN NQO1 1

30,851

100.00%

5

6

12

Splicing factor, arginine/serine-rich 4 SFRS4_HUMAN SFRS4

56,662

100.00%

3

3

8

Proliferation-associated protein 2G4 PA2G4_HUMAN PA2G4

43,769

100.00%

21

23

195

SNPEIQDFMR TEIEDFPR 21.20% ALIVLAHSER EAAAAALKK EGHLSPDIVAEQK IQILEGWK LKDPANFQYPAESVLAYK 11.90% GESENAGTNQETR LDGTEVNGR LIVENLSSR LVEDKPGSR QAGEVTYADAHK VIVEHAR 54.30% AAHLCAEAALR AFFSEVER ALLQSSASR EGEFVAQFK FDAMPFTLR FTVLLMPNGPMR GDAMIMEETGK HELLQPFNVLYEK ITSGPFEPDLYK ITSGPFEPDLYKSEMEVQDAELK

AMPL_HUMAN LAP3

56,150

100.00%

6

6

10

Phosphoribosylformylglycinamidine PUR4_HUMAN PFAS synthase

144,706

100.00%

8

8

14

8,547

100.00%

5

6

102

Cytosol aminopeptidase

Ubiquitin

UBIQ_HUMAN RPS27A

LVKPGNQNTQVTEAWNK MGGDIANR MGVVECAK RFDAMPFTLR SDQDYILK SEMEVQDAELK SLVEASSSGVSVLSLCEK TAENATSGETLEENEAGD TIIQNPTDQQK TIIQNPTDQQKK VAHSFNCTPIEGMLSHQLK 16.00% EKEDDVPQFTSAGENFDK GITFDSGGISIK GSPNANEPPLVFVGK GVLFASGQNLAR QLMETPANEMTPTR TIQVDNTDAEGR 6.35% ELSDPAGAIIYTSR EPGGPSPR FGEPVLAGFAR FQQQQGLR LNFSTPTSTNIVSVCR SLGLQLPDGQR VGPGPALMLR VGTETVR 69.70% ESTLHLVLR IQDKEGIPPDQQR QLEDGR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

52.0 37.6 63.9 33.0 67.4 43.9 54.7 54.6 53.3 52.6 59.5 51.6 44.6 45.9 57.6 61.4 47.2 51.3 59.7 63.8 72.8 76.7 49.8 63.5 67.6 30.8 31.1 62.0 78.2 86.1 104.0 51.4 53.7 28.6 32.7 40.7 48.0 46.7 59.7 62.5 77.4 32.1 62.2 33.8 68.5 51.1 32.2 40.9 46.9 73.5 31.8

19.6 22.1 18.3 21.8 22.7 23.1 21.2 18.0 22.7 21.6 22.0 21.4 18.7 22.1 21.1 22.0 21.9 21.5 22.7 19.7 21.5 22.5 21.6 21.0 21.4 21.8 21.6 22.0 20.6 22.3 16.0 22.0 21.1 21.5 19.2 22.0 22.4 23.0 20.9 21.7 23.0 20.2 23.0 23.9 22.0 20.8 18.8 25.0 18.4 21.4 20.8

8 3 2 1 3 2 1 1 3 11 4 3 4 0 12 16 9 8 6 19 6 7 0 6 7 1 1 11 10 14 10 17 4 0 0 1 2 2 2 2 2 1 3 1 2 2 2 1 11 13 1

0 0 0 0 0 0 3 0 0 0 0 0 0 7 0 0 0 0 0 0 8 0 8 7 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,252.56 1,006.48 1,108.65 872.52 1,422.72 986.57 2,054.06 1,392.60 960.48 1,030.59 1,000.54 1,289.61 823.48 1,182.61 984.48 932.52 1,054.52 1,113.54 1,391.72 1,213.51 1,629.86 1,366.69 2,626.26 1,927.00 849.39 909.42 1,269.64 981.49 1,294.58 1,851.94 1,837.76 1,285.68 1,413.77 2,185.05 2,055.92 1,194.64 1,525.80 1,232.68 1,650.75 1,318.62 1,492.76 796.40 1,163.62 1,004.53 1,795.90 1,183.64 1,010.58 761.42 1,067.62 1,523.78 717.35

Table S1 page 150/159

Cathepsin D

CATD_HUMAN CTSD

44,535

100.00%

14

16

473

Histidyl-tRNA synthetase, cytoplasmic

SYHC_HUMAN HARS

57,394

100.00%

7

7

16

TITLEVEPSDTIENVK TLSDYNIQK 38.60% AIGAVPLIQGEYMIPCEK DPDAQPGGELMLGGTDSK FDGILGMAYPR ISVNNVLPVFDNLMQQK LVDQNIFSFYLSR QPGITFIAAK QVFGEATK RTMSEVGGSVEDLIAK TMSEVGGSVEDLIAK VGFAEAAR VGFAEAARL VSTLPAITLK YSQAVPAVTEGPIPEVLK YYTVFDRDNNR 16.90% AQLGPDESK ASAELIEEEVAK DQGGELLSLR HGAEVIDTPVFELK IFSIVEQR IGDYVQQHGGVSLVEQLLQDPK

Leukotriene A-4 hydrolase

LKHA4_HUMAN LTA4H

69,269

100.00%

12

12

34

60S acidic ribosomal protein P0

RLA0_HUMAN RPLP0

34,256

100.00%

5

5

18

Cathepsin L1

CATL1_HUMAN CTSL1

37,546

100.00%

6

7

70

Pirin

PIR_HUMAN

32,096

100.00%

5

5

13

PIR

LVSELWDAGIK 29.30% DGETPDPEDPSR DLSSHQLNEFLAQTLQR EDDLNSFNATDLK ELVALMSAIR GSPMEISLPIALSK HFNALGGWGELQNSVK LVVDLTDIDPDVAYSSVPYEK MQEVYNFNAINNSEIR SAYEFSETESMLK SLSNVIAHEISHSWTGNLVTNK SSALQWLTPEQTSGK WEDAIPLALK 23.00% AFLADPSAFVAAAPVAAATTAAPAAAAAPAK GHLENNPALEK GNVGFVFTK IIQLLDDYPK TSFFQALGITTK 22.20% HSFTMAMNAFGDMTSEEFR LYGMNEEGWR MIELHNQEYR NSWGEEWGMGGYVK QVMNGFQNR VFQEPLFYEAPR 18.30% MNPGDLQWMTAGR MVEPQYQELK NLDPFLLFDEFK SEEIPKPSK TPTLYLDFK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

86.7 44.2 82.5 114.0 84.1 61.3 78.4 41.5 34.4 57.0 95.3 64.6 50.2 35.2 98.8 31.4 45.6 74.5 58.1 55.7 71.9 49.2 66.1 35.3 36.9 90.2 66.7 75.6 37.0 99.6 110.0 58.1 57.2 60.9 37.4 47.2 41.4 49.2 76.7 103.0 44.7 55.8 54.0 96.3 60.7 78.0 77.8 34.2 38.8 39.7 41.0

21.8 22.3 22.0 20.3 22.0 20.6 22.6 20.5 22.7 22.8 23.2 25.0 22.9 13.8 19.4 20.3 21.2 23.2 23.7 21.6 20.5 20.3 22.6 16.3 21.8 20.8 21.6 21.5 22.3 21.9 20.7 18.6 20.4 23.3 19.7 18.3 23.5 21.8 22.0 21.7 13.4 20.5 22.5 17.6 21.6 22.0 20.2 22.5 23.0 22.3 21.0

71 3 18 56 74 110 39 7 1 1 67 32 3 3 34 1 2 4 2 2 2 0 2 6 0 2 4 4 0 3 2 2 0 2 2 0 1 2 6 8 0 8 9 4 2 44 4 2 1 4 2

0 0 0 0 0 20 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 0 0 1 0 0 0 4 0 0 1 0 0 0 0 2 0 1 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,787.93 1,081.55 2,005.01 1,803.81 1,239.62 1,959.04 1,601.83 1,045.60 879.46 1,707.86 1,535.76 820.43 933.52 1,042.65 1,898.03 1,462.67 944.47 1,288.66 1,087.58 1,554.82 991.56 2,423.26 1,230.67 1,314.55 2,000.02 1,481.68 1,102.63 1,458.79 1,756.88 2,338.17 1,957.91 1,521.68 2,407.24 1,632.82 1,155.64 2,752.47 1,221.62 968.52 1,217.68 1,313.71 2,240.91 1,254.56 1,332.64 1,615.69 1,109.52 1,495.76 1,492.67 1,280.62 1,497.76 1,014.55 1,097.59

Table S1 page 151/159

Peroxiredoxin-4

PRDX4_HUMAN PRDX4

30,523

100.00%

5

6

15

Bifunctional aminoacyl-tRNA synthetase

SYEP_HUMAN EPRS

170,575

100.00%

3

3

9

Eukaryotic translation initiation factor 3 subunit B

EIF3B_HUMAN EIF3B

92,465

100.00%

6

6

30

Protocadherin-7

PCDH7_HUMAN PCDH7

116,054

100.00%

6

7

14

Coatomer subunit delta

COPD_HUMAN ARCN1

57,193

100.00%

6

6

24

Plastin-2

PLSL_HUMAN LCP1

70,274

100.00%

25

27

141

29.20% DYGVYLEDSGHTLR GLFIIDDK GLFIIDDKGILR IPLLSDLTHQISK LVQAFQYTDK QITLNDLPVGR SVDETLR VSVADHSLHLSK 2.84% DQDLEPGAPSMGAK LTVAENEAETK NQGGGLSSSGAGEGQGPK 9.46% AQAVSEDAGGNEGR GTQGVVTNFEIFR ITNDFYPEEDGKTK MAQELYMEQK TSIFWNDVKDPVSIEER VTLMQLPTR 7.76% LDASEGGGGTNPGGR LFEIDPTSGVVSLVGK RLDASEGGGGTNPGGR SVYEADLAENSAPGTPILQLR VATVLATDADSGK YELLQEPGGGGSGGESR 13.70% GVQLQTHPNVDKK IEGLLAAFPK LFTAESLIGLK NTLEWCLPVIDAK SFPVNSDVGVLK VTQVDGNSPVR 46.90% AACLPLPGYR ALENDPDCR AYYHLLEQVAPK EGESLEDLMK EKDDIQR FSLVGIGGQDLNEGNR GDEEGVPAVVIDMSGLR GSVSDEEMMELR IGNFSTDIK IGNFSTDIKDSK IKVPVDWNR ISFDEFIK KLENCNYAVELGK LSPEELLLR MINLSVPDTIDER NEALIALLR NWMNSLGVNPR QFVTATDVVR TENLNDDEKLNNAK VDTDGNGYISFNELNDLFK VNDDIIVNWVNETLR VYALPEDLVEVNPK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

76.8 47.4 53.2 55.2 58.8 53.0 53.7 59.9 46.5 63.4 77.1 108.0 65.3 32.8 47.5 27.0 65.4 59.6 88.6 45.3 61.6 52.3 62.4 45.2 43.6 64.9 55.3 38.1 71.0 40.5 37.8 52.5 41.0 31.1 86.3 54.7 64.4 48.0 38.9 40.1 45.9 63.0 67.1 66.8 77.8 48.9 65.2 87.2 76.0 97.8 52.8

21.9 20.5 15.6 17.1 21.3 19.9 24.7 21.8 20.2 23.2 21.3 18.6 22.1 20.8 17.6 22.9 22.3 19.2 20.1 21.1 20.9 23.2 22.9 20.8 20.4 16.7 23.1 22.3 22.1 24.2 16.5 22.6 22.0 22.3 22.3 21.4 15.8 21.6 21.7 20.3 20.5 22.8 17.1 22.8 16.0 22.1 23.3 21.4 21.6 21.8 20.8

2 11 9 3 2 4 2 1 3 2 4 15 4 1 2 0 7 2 2 1 1 2 2 1 2 6 1 1 13 2 3 2 1 1 8 7 1 2 1 0 4 2 7 24 6 2 11 7 2 26 2

0 0 5 3 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 4 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 2 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,624.76 920.51 1,359.80 1,464.84 1,212.63 1,225.69 819.42 1,292.70 1,431.64 1,204.61 1,587.74 1,360.61 1,467.76 1,656.78 1,302.57 2,035.01 1,058.60 1,344.61 1,660.92 1,500.72 2,244.15 1,247.65 1,692.78 1,463.80 1,058.63 1,191.70 1,558.79 1,261.68 1,171.61 1,117.58 1,089.46 1,431.76 1,150.53 903.45 1,675.84 1,743.86 1,414.58 994.52 1,324.68 1,126.64 998.52 1,537.77 1,069.63 1,518.75 1,012.62 1,287.63 1,135.61 1,617.77 2,161.01 1,799.93 1,585.85

Table S1 page 152/159

YAFVNWINK YPALHKPENQDIDWGALEGETR

Histone-binding protein RBBP4

RBBP4_HUMAN RBBP4

47,638

100.00%

6

6

26

Fatty acid synthase

FAS_HUMAN FASN

273,409

100.00%

14

14

62

Hepatoma-derived growth factor

HDGF_HUMAN HDGF

26,771

100.00%

9

12

59

YTLNILEEIGGGQK 16.50% IGEEQSPEDAEDGPPELLFIHGGHTAK LMIWDTR LNVWDLSK TPSSDVLVFDYTK TVALWDLR VINEEYK 6.69% AAEQYTPK DNLEFFLAGIGR EDGLAQQQTQLNLR FPQLDSTSFANSR GLVQALQTK GNAGQSNYGFANSAMER LPEDPLLSGLLDSPALK LQVVDQPLPVR SEGVVAVLLTK SLLVNPEGPTLMR TPEAVQK VLEALLPLK VLQGDLVMNVYR VVVQVLAEEPEAVLK ISSSDLSLGHVTR SSGFPVHLLPDIAEPGSVAGR 42.50% AGDLLEDSPK DLFPYEESKEK EAATLEVERPLPMEVEK EAENPEGEEK EAENPEGEEKEAATLEVERPLPMEVEK

GFSEGLWEIENNPTVK GPPQEEEEEEDEEEEATKEDAEAPGIR

Caprin-1

CAPR1_HUMAN CAPRIN1

78,346

100.00%

3

3

14

4.23%

Cytoplasmic FMR1-interacting protein 1

CYFP1_HUMAN CYFIP1

145,169

100.00%

6

6

9

5.67%

Niban-like protein 1

NIBL1_HUMAN FAM129B

82,666

99.50%

2

2

6

3.27%

Aldo-keto reductase family 1 member C3

AK1C3_HUMAN AKR1C3

36,827

100.00%

14

16

233

44.60%

IDEMPEAAVK KGFSEGLWEIENNPTVK LDDYQER LNQDQLDAVSK YQEVTNNLEFAK AVGPSSTQLYMVR LGTPQQIAIAR NVIQSVLQAIR SLLQGTILQYVK SSLEGPTILDIEK TVLPFSQEFQR FQELIFEDFAR VQQVQPAMQAVIR AIDGLDR HIDSAHLYNNEEQVGLAIR IADGSVKR LAIEAGFR LNDGHFMPVLGFGTYAPPEVPR QLEMILNKPGLK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 94.6% 95.0% 95.0% 95.0% 95.0% 95.0%

34.8 75.4 100.0 62.8 34.4 43.3 89.5 52.7 32.2 36.0 44.6 78.7 70.1 34.6 79.3 87.2 56.2 53.5 50.8 31.6 53.6 63.9 70.3 35.2 51.0 54.7 35.4 42.0 42.8 49.0 68.6 75.4 60.5 92.6 41.3 60.8 52.2 47.8 51.3 43.2 41.5 50.5 42.1 54.6 65.7 30.0 82.9 45.2 46.2 71.0 56.0

20.9 22.0 22.2 20.3 23.5 22.5 23.1 23.2 22.2 23.4 21.6 22.0 22.0 20.0 16.4 17.3 17.2 19.2 21.4 19.8 8.5 22.3 15.1 22.2 21.1 21.2 22.0 22.3 16.1 20.9 23.4 14.6 21.9 21.8 20.1 23.2 22.4 22.7 16.8 17.3 15.7 22.0 21.6 22.6 21.3 23.4 22.0 23.3 23.1 20.9 17.6

1 0 2 0 2 3 5 13 1 1 2 4 9 3 1 7 8 4 4 1 7 2 9 1 0 1 2 2 2 0 17 0 15 3 2 5 7 1 2 1 1 2 2 2 4 1 0 1 52 1 9

0 2 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 2 1 7 0 5 0 0 0 0 0 0 0 0 0 0 0 0 56 0 0 6 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,154.60 2,539.22 1,534.81 2,873.36 934.48 974.53 1,471.73 973.55 894.46 907.45 1,351.70 1,613.83 1,469.70 957.57 1,789.76 1,778.00 1,263.74 1,115.67 1,442.77 772.42 995.65 1,422.74 1,622.94 1,371.72 2,106.10 1,044.52 1,384.66 1,957.00 1,131.48 3,053.46 1,819.89 3,042.28 1,118.54 1,947.98 938.42 1,230.63 1,455.71 1,424.72 1,167.69 1,240.74 1,362.80 1,401.75 1,351.70 1,414.70 1,483.81 759.40 2,179.09 845.48 876.49 2,430.19 1,383.80

Table S1 page 153/159

REDIFYTSK RQLEMILNKPGLK RTPALIALR SIGVSNFNR SKDIVLVAYSALGSQR TPALIALR WVDPNSPVLLEDPVLCALAK YQLQR EGFVEYTEQVVK LLSSAFDEVYPALPSDVQTAIK LVLEQVVTSIASVADTAEEK NLIDEDGNNQWPEGLK NTTAAEEAR SLVEIADTVPK VCDIAAELAR VIAALLQTMEDQGNQR DIQLENYTPK DIQLENYTPKEPLTLQAR EPLTLQAR EVVDILTEQLR MWTTVHPGAR IAQSDYIPTQQDVLR LLLLGAGESGK ADSYYEYLLK IPYSDVNIGTGVAHPPR QETQLLEDYVEAIEGVR VPSGGYSSINNVQDPQKPEPR DIVQFVPYR EALAQTVLAEVPTQLVSYFR FGIYDIDNK FQNAPR LYGPTNFAPIINHVAR SDPFLEFFR GQSEVSAAQLQER IAVAGDLFQPER LLDLDEAAYK AFGYYGPLR NPPGFAFVEFEDPR NPPGFAFVEFEDPRDAADAVR VYVGNLGNNGNKTELER

Importin-5

IPO5_HUMAN IPO5

123,614

100.00%

8

9

18

10.60%

NKG2D ligand 2

N2DL2_HUMAN ULBP2

27,351

100.00%

5

6

66

15.90%

Guanine nucleotide-binding protein G(i) subunit alpha-2 Endoplasmic reticulum mannosyloligosaccharide 1,2-alphamannosidase

GNAI2_HUMAN GNAI2

40,434

99.50%

2

2

5

7.32%

MA1B1_HUMAN MAN1B1

79,564

100.00%

4

4

10

9.30%

Copine-1

CPNE1_HUMAN CPNE1

59,041

100.00%

6

6

14

12.80%

Growth arrest-specific protein 6

GAS6_HUMAN GAS6

79,658

100.00%

3

3

13

4.85%

Splicing factor, arginine/serine-rich 3 SFRS3_HUMAN SFRS3

19,312

100.00%

4

5

24

28.70%

CALR_HUMAN CALR

48,125

100.00%

14

20

158

44.40% AKIDDPTDSKPEDWDKPEHIPDPDAK EQFLDGDGWTSR FYALSASFEPFSNK FYGDEEKDK GLQTSQDAR

Calreticulin

IDDPTDSKPEDWDKPEHIPDPDAK

IDNSQVESGSLEDDWDFLPPK IDNSQVESGSLEDDWDFLPPKK IKDPDASKPEDWDER KPEDWDEEMDGEWEPPVIQNPEYK

KVHVIFNYK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

38.6 28.1 37.6 53.8 60.2 70.5 86.9 30.5 44.9 48.1 108.0 60.5 37.3 59.9 32.8 81.9 59.5 94.6 37.6 87.0 38.2 52.5 57.8 41.7 35.2 81.6 40.8 45.7 76.4 42.5 31.9 36.9 71.8 110.0 74.3 50.4 54.3 79.2 54.6 27.7 37.9 66.6 103.0 47.9 55.9 31.7 137.0 97.1 66.3 63.1 28.1

21.6 14.5 10.0 22.6 18.8 14.8 21.1 22.5 22.4 20.3 19.7 22.4 21.3 22.7 23.3 22.3 23.4 20.8 19.0 22.4 21.1 22.2 20.1 22.7 21.5 22.0 22.0 22.5 17.4 22.2 23.0 20.6 21.0 22.7 22.5 22.0 22.3 22.1 21.4 22.6 20.5 19.7 21.9 18.4 23.0 19.5 20.2 21.5 21.8 17.1 18.3

15 0 2 6 0 31 2 2 1 1 2 1 2 4 2 4 6 7 5 38 4 2 3 2 0 2 0 2 3 2 1 0 4 5 4 4 8 7 3 0 0 29 13 4 5 0 11 6 5 0 0

0 2 0 0 26 0 0 0 0 0 1 0 0 0 0 0 0 6 0 0 0 0 0 0 2 0 4 0 0 0 0 2 0 0 0 0 0 0 5 1 3 0 0 3 0 1 0 51 2 13 1

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 1 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,158.58 1,539.90 1,010.65 993.51 1,706.94 854.55 2,236.17 707.38 1,427.71 2,364.23 2,102.12 1,841.87 962.45 1,171.66 1,117.57 1,802.91 1,220.62 2,129.12 927.53 1,314.73 1,171.57 1,746.90 1,057.63 1,264.61 1,792.93 1,991.99 2,269.12 1,136.61 2,235.20 1,084.53 732.38 1,782.97 1,157.56 1,402.69 1,315.70 1,150.60 1,043.53 1,621.77 2,320.10 1,876.95 2,959.40 1,410.63 1,607.77 1,130.50 975.49 2,760.26 2,391.10 2,519.19 1,800.84 2,976.29 1,147.66

Table S1 page 154/159

LFPNSLDQTDMHGDSEYNIMFGPDICGPGTK

Tubulointerstitial nephritis antigenlike

TINAL_HUMAN TINAGL1

52,369

100.00%

16

17

194

NVLINK QIDNPDYK 48.00% ELAPGLHLR ELMENGPVQALMEVHEDFFLYK

GGIYSHTPVSLGRPER GVNECDIESFVLGVWGR GVVSDHCYPFSGR HGTHSVK ITGWGEETLPDGR IYPVLGTYWDNCNR LDGAWWFLR LGSNDKEIMK LGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEK

QATAHCPNSYVNNNDIYQVTPVYR

Adenosine kinase

ADK_HUMAN ADK

40,529

100.00%

4

4

6

11.30%

Pigment epithelium-derived factor

PEDF_HUMAN SERPINF1

46,326

100.00%

7

7

23

19.90%

Reticulocalbin-2

RCN2_HUMAN RCN2

36,860

99.50%

2

2

4

12.30%

DNA damage-binding protein 1

DDB1_HUMAN DDB1

126,952

100.00%

21

22

64

19.70%

RELAPGLHLR VGMEDMGHH YCQEQDLCCR YWTAANSWGPAWGER ELFDELVK IVIFTQGR VAQWMIQQPHK YSLKPNDQILAEDK DTDTGALLFIGK ELLDTVTAPQK LAAAVSNFGYDLYR LDLQEINNWVQAQMK LQSLFDSPDFSK LTQVEHR TSLEDFYLDEER LSEEEILENPDLFLTSEATDYGR WDPTANEDPEWILVEK ALVSEWKEPQAK ALYYLQIHPQELR DSAATTDEER EATADDLIK EMLGGEIIPR GDFILVGDLMR IAVMELFRPK IEVQDTSGGTTALRPSASTQALSSSVSSSK

IVVFQYSDGK LEELHVIDVK LPSFELLHK LQTVAEK LVFSNVNLK LVSQEPK LYEWTTEK QGQGQLVTCSGAFK TVPLYESPR VTLGTQPTVLR VVEELTR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

56.1 30.6 51.7 44.1 27.5 33.0 43.6 62.7 42.6 90.1 78.4 73.5 34.3 35.0 55.6 56.2 38.2 50.7 82.9 34.3 33.7 27.6 32.2 81.0 41.5 72.0 56.2 69.2 63.7 61.2 45.2 52.1 53.9 34.2 57.8 32.6 63.9 46.7 66.8 47.2 63.5 54.0 32.9 30.7 49.2 33.2 30.6 78.1 37.0 74.0 39.9

15.6 22.0 22.1 18.5 21.0 21.2 21.8 19.9 22.6 22.2 21.4 23.1 22.8 19.3 21.0 16.8 12.0 9.5 22.3 20.9 19.6 22.7 22.2 22.3 22.6 23.1 22.3 22.7 21.0 19.6 21.0 20.8 21.7 20.5 16.5 23.3 22.0 22.8 18.3 20.3 21.7 18.6 19.5 23.7 17.6 21.1 20.5 22.1 22.3 19.2 23.4

0 1 5 7 0 1 3 4 4 51 11 75 3 0 0 0 3 5 9 1 3 0 0 6 4 2 2 6 1 2 1 3 2 0 4 2 8 2 2 0 4 2 1 1 4 1 1 2 1 15 3

2 0 0 0 1 0 0 0 0 0 0 0 11 1 2 3 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 5 0 0 1 0 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

3,488.51 700.44 992.47 1,005.58 2,671.24 1,725.90 1,936.92 1,480.66 765.40 1,430.69 1,770.83 1,163.60 1,150.58 3,849.90 2,824.31 1,161.69 1,028.39 1,431.55 1,751.79 992.53 933.55 1,365.71 1,633.84 1,250.66 1,214.66 1,559.79 1,845.92 1,383.68 882.48 1,516.68 2,641.25 1,941.92 1,385.74 1,643.89 1,094.46 975.50 1,114.59 1,235.65 1,203.69 2,952.48 1,155.61 1,194.67 1,083.62 788.45 1,033.60 800.45 1,069.52 1,480.72 1,061.56 1,184.70 845.47

Table S1 page 155/159

Protein FAM3C

FAM3C_HUMAN FAM3C

24,663

100.00%

11

13

412

54.60%

60S ribosomal protein L22

RL22_HUMAN RPL22

14,769

99.50%

2

2

3

18.80%

Sortilin

SORT_HUMAN SORT1

92,052

99.50%

2

2

2

2.29%

Heterogeneous nuclear ribonucleoprotein A1

ROA1_HUMAN HNRNPA1

38,729

100.00%

10

14

257

39.50%

YLAIAPPIIK YLLGDMEGR AIQDGTIVLMGTYDDGATK GINVALANGK ICLEDNVLMSGVK LIADLGSTSITNLGFR MASGAANVVGPK MDASLGNLFAR SALDTAAR SPFEQHIK TGEVLDTK TKSPFEQHIK YFDMWGGDVAPFIEFLK AGNLGGGVVTIER ITVTSEVPFSK ADLGALELWR IYSFGLGGR DYFEQYGK EDSQRPGAHLTVK EDTEEHHLR GFAFVTFDDHDSVDK GFGFVTYATVEEVDAAMNARPHK

Basic leucine zipper and W2 domain-containing protein 1

BZW1_HUMAN BZW1

Testin

TES_HUMAN

Fascin

FSCN1_HUMAN FSCN1

TES

48,027

100.00%

4

4

10

47,978

100.00%

4

4

17

54,512

100.00%

25

32

511

IEVIEIMTDR IFVGGIK IFVGGIKEDTEEHHLR KLFIGGLSFETTDESLR LFIGGLSFETTDESLR NQGGYGGSSSSSSYGSGR SESPKEPEQLR SSGPYGGGGQYFAKPR 8.83% AEVLSEEPILK DINAVAASLR GFSESER LMELFPANK 10.90% EGDPAIYAER NVMILTNPVAAK QPVAGSEGAQYR STPAAVGAMEDK 61.30% DVPWGVDSLITLAFQDQR FLIVAHDDGR GDHAGVLK KVTGTLDANR LINRPIIVFR LSCFAQTVSPAEK LVARPEPATGYTLEFR NGQLAASVETAGDSELFLMK QGMDLSANQDEETDQETFQLEIDR QGMDLSANQDEETDQETFQLEIDRDTK

QIWTLEQPPDEAGSAAVCLR SSYDVFQLEFNDGAYNIK VGKDELFALEQSCAQVVLQAANER

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

31.1 42.5 145.0 52.1 77.2 149.0 92.1 81.6 64.1 57.2 48.8 38.0 62.0 48.1 58.1 64.7 30.5 47.3 59.3 44.3 78.1 32.7 72.2 34.6 41.6 47.9 124.0 128.0 49.8 99.9 73.6 43.6 35.8 34.2 41.7 70.3 36.2 48.5 51.9 57.9 50.2 44.6 46.0 99.6 65.3 82.5 48.1 83.5 90.4 115.0 72.7

16.0 23.0 22.3 20.2 23.2 19.5 21.8 23.3 23.6 20.8 24.6 21.1 21.2 22.9 22.0 22.6 21.5 19.2 22.1 20.9 20.1 22.0 23.6 16.5 21.8 21.6 21.4 15.7 21.9 21.7 20.2 21.3 17.7 23.6 22.6 20.3 23.0 22.0 21.6 22.4 18.9 23.2 10.4 21.8 20.7 22.1 16.5 16.8 21.6 21.5 20.8

1 1 143 3 10 133 60 6 9 25 6 0 2 1 2 1 1 9 22 5 25 0 33 1 0 2 99 14 18 4 4 2 1 3 1 6 2 8 1 17 3 4 4 9 24 20 0 0 4 34 0

0 0 1 0 0 8 0 0 0 0 0 6 0 0 0 0 0 0 0 0 2 0 0 0 17 1 0 0 20 1 0 0 0 0 0 0 0 0 0 11 0 1 33 0 69 0 5 10 0 0 10

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,098.69 1,053.50 1,984.95 956.55 1,493.73 1,677.92 1,101.57 1,194.59 804.42 985.51 862.45 1,214.65 2,050.96 1,242.68 1,207.66 1,143.62 969.52 1,049.46 1,437.75 1,165.52 1,699.76 2,526.21 1,234.64 733.46 1,879.97 1,913.00 1,784.91 1,694.70 1,299.65 1,628.78 1,227.68 1,029.57 811.36 1,062.57 1,120.53 1,270.72 1,262.61 1,192.55 2,060.05 1,142.60 796.43 1,074.59 1,240.79 1,437.70 1,819.97 2,097.02 2,828.22 3,172.39 2,241.10 2,109.98 2,675.35

Table S1 page 156/159

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

DDAH1_HUMAN DDAH1

31,104

100.00%

7

8

29

33.00%

Proteasome subunit beta type-6

PSB6_HUMAN PSMB6

25,340

100.00%

6

7

28

21.30%

Ribosyldihydronicotinamide dehydrogenase [quinone] Alpha-centractin

NQO2_HUMAN NQO2

25,935

99.50%

2

3

5

13.00%

ACTZ_HUMAN ACTR1A

42,597

100.00%

3

3

4

12.50%

Amyloid beta A4 protein

A4_HUMAN

86,923

100.00%

16

19

237

22.60%

Thioredoxin domain-containing protein 17

TXD17_HUMAN TXNDC17

13,922

100.00%

5

6

16

43.90%

APP

VNASASSLK VNASASSLKK VTGTLDANR WSLQSEAHR YAHLSARPADEIAVDR YFGGTEDR YLAADKDGNVTCER YLAPSGPSGTLK YLKGDHAGVLK YLTAEAFGFK YSVQTADHR YWTLTATGGVQSTASSK ALPESLGQHALR DYAVSTVPVADGLHLK GAEILADTFK SAKGEEVDVAR SFCSMAGPNLIAIGSSESAQK TPEEYPESAK VDGLLTCCSVLINK DGSSGGVIR LAAIAESGVER LTPIHDR QVLLGDQIPK TTTGSYIANR VTDKLTPIHDR SLASDITDEQKK VLAPQISFAPEIASEEER AQYYLPDGSTIEIGPSR DQLQTFSEEHPVLLTEAPLNPR EYEEDGAR AVIQHFQEKVESLEQEAANER CAPFFYGGCGGNR CLVGEFVSDALLVPDK EQNYSDDVLANMISEPR ISYGNDALMPSLTETK LALENYITALQAVPPRPR MDAEFR MSQVMR MSQVMREWEEAER QQLVETHMAR SQVMTHLR THPHFVIPYR VEAMLNDR VESLEQEAANER WDSDPSGTK WYFDVTEGK DPNNDFR SWCPDCVQAEPVVR TIFAYFTGSK VTAVPTLLK YEEVSVSGFEEFHR

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

62.8 51.6 60.7 57.7 18.8 51.8 81.6 44.2 47.3 45.8 66.2 149.0 37.3 76.4 51.5 47.0 73.3 61.9 81.4 76.0 98.9 31.2 34.5 67.8 48.7 62.2 78.4 35.4 39.9 33.1 51.5 31.8 83.1 109.0 90.6 85.2 32.5 37.9 33.3 47.2 31.2 36.9 57.2 79.8 40.1 43.8 32.0 84.4 43.0 40.8 54.4

22.9 18.9 23.6 22.0 22.0 17.0 21.0 22.5 22.3 23.8 22.2 22.4 20.8 21.8 23.3 23.5 21.6 21.0 22.7 23.6 23.0 20.7 17.8 22.0 21.0 23.0 21.4 22.1 20.3 16.2 20.6 13.4 22.8 19.6 21.8 14.1 17.9 20.2 18.7 21.9 21.4 21.4 21.9 21.3 19.2 19.8 18.1 19.9 23.8 11.8 20.3

8 7 12 21 0 8 2 3 3 12 24 140 2 3 2 2 2 12 2 4 8 1 1 10 2 2 2 1 0 1 0 2 3 27 16 2 2 2 0 2 2 0 32 33 3 8 2 2 3 4 2

0 0 0 1 0 0 0 0 9 0 1 0 0 0 0 4 0 0 0 0 0 0 0 0 2 0 1 0 2 0 11 0 0 2 0 59 0 0 1 2 0 28 0 0 0 0 0 0 0 0 3

0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

876.48 1,004.57 946.50 1,113.54 1,783.91 944.41 1,611.74 1,190.64 1,200.67 1,146.58 1,076.51 1,757.87 1,291.71 1,684.89 1,064.56 1,160.59 2,155.02 1,150.53 1,591.82 847.43 1,115.61 851.47 1,110.65 1,083.54 1,294.71 1,334.68 1,986.02 1,866.92 2,534.29 968.40 2,455.22 1,462.60 1,761.91 1,996.89 1,739.85 2,022.15 768.34 767.35 1,712.74 1,212.62 971.51 1,266.67 963.46 1,374.65 992.43 1,144.53 877.38 1,702.77 1,134.58 941.60 1,714.77

Table S1 page 157/159

Complement C3

CO3_HUMAN C3

187,131

100.00%

33

35

98

25.60% ADIGCTPGSGK AEDLVGK AGDFLEANYMNLQR APSTWLTAYVVK AYYENSPQQVFSTEFEVK EYVLPSFEVIVEPTEK FYYIYNEK GYTQQLAFR ILLQGTPVAQMTEDAVDAER IPIEDGSGEVVLSR ISLPESLKR KQELSEAEQATR LVAYYTLIGASGQR NTMILEICTR QELSEAEQATR QLANGVDR QNQELK QPSSAFAAFVK SEETKENEGFTVTAEGK SGQSEDRQPVPGQQMTLK SGSDEVQVGQQR SNLDEDIIAEENIVSR SSLSVPYVIVPLK TIYTPGSTVLYR TMQALPYSTVGNSNNYLHLSVLR

TVMVNIENPEGIPVK VFLDCCNYITELR VHQYFNVELIQPGAVK VLLDGVQNPR VPVAVQGEDTVQSLTQGDGVAK

Sushi repeat-containing protein SRPX2

SRPX2_HUMAN SRPX2

52,954

100.00%

4

4

26

11.00%

Fumarylacetoacetase

FAAA_HUMAN FAH

46,358

100.00%

4

4

9

10.50%

27,350

100.00%

2

2

6

13.90%

22,970

100.00%

10

12

74

62.70%

Splicing factor, arginine/serine-rich 7 SFRS7_HUMAN SFRS7

Rho GDP-dissociation inhibitor 2

GDIR2_HUMAN ARHGDIB

VQLSNDFDEYIMAIEQTIK VTIKPAPETEK YYTYLIMNK DSADGTITR EQQLSANIIEELR HVTIIELVGQPPQEVGR LLIISAPDPSNR ASSVVVSGTPIR HLFTGPVLSK LGEPIPISK VFLQNLLSVSQAR NPPGFAFVEFEDPR NPPGFAFVEFEDPRDAEDAVR VYVGNLGTGAGK APEPHVEEDDDDELDSK APEPHVEEDDDDELDSKLNYKPPPQK

APNVVVTR ATFMVGSYGPRPEEYEFLTPVEEAPK

ELQEMDKDDESLIK LNYKPPPQK LTLVCESAPGPITMDLTGDLEALKK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

45.8 41.6 71.1 53.1 74.1 81.1 37.2 48.3 119.0 100.0 32.7 73.7 54.1 34.6 58.8 68.4 39.3 31.7 31.4 49.3 71.4 91.5 54.2 37.9 34.3 50.9 65.7 32.3 52.4 90.8 133.0 40.1 37.5 53.9 62.1 34.5 55.1 79.4 34.2 34.9 84.4 79.2 36.5 42.8 103.0 21.0 52.3 61.1 64.9 28.2 31.3

21.2 24.4 21.5 20.4 21.3 21.1 22.6 21.5 21.9 22.0 18.6 22.9 20.5 22.8 22.3 21.3 23.4 22.6 21.5 21.6 21.1 22.3 12.0 21.1 20.6 21.5 20.9 19.8 20.2 21.4 21.2 19.3 22.5 22.9 21.8 18.1 17.4 22.4 18.6 14.9 18.4 22.1 20.5 22.8 16.2 20.4 18.1 21.8 23.0 19.8 20.8

1 2 7 2 3 4 2 3 10 2 1 2 3 1 2 2 1 1 0 2 10 4 9 1 0 2 2 0 2 3 2 1 2 6 1 0 15 4 2 1 2 7 0 2 4 0 13 0 11 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 0 0 2 0 2 0 2 0 0 0 4 0 0 0 0 0 0 4 0 4 0 0 12 1 4 3

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

1,062.49 731.39 1,657.76 1,335.73 2,166.00 1,878.97 1,139.54 1,083.56 2,173.08 1,470.78 1,042.63 1,389.70 1,511.82 1,266.62 1,261.60 872.46 759.40 1,152.61 1,855.86 2,001.97 1,289.61 1,816.89 1,401.84 1,370.73 2,594.30 1,655.87 1,702.79 1,841.99 1,110.63 2,198.13 2,273.10 1,212.68 1,224.60 935.44 1,542.81 1,872.03 1,295.73 1,172.66 1,098.63 953.57 1,474.84 1,621.77 2,378.11 1,135.61 1,939.80 3,005.40 855.51 2,960.40 1,692.80 1,084.62 2,688.38

Table S1 page 158/159

Peroxiredoxin-1

PRDX1_HUMAN PRDX1

22,093

100.00%

14

17

183

55.30%

Proteasome subunit alpha type-3

PSA3_HUMAN PSMA3

28,416

100.00%

10

11

77

37.60%

Tyrosine-protein kinase-like 7

PTK7_HUMAN PTK7

118,374

100.00%

6

6

13

7.38%

Syntaxin-12

STX12_HUMAN STX12

31,625

99.50%

2

2

2

10.50%

Apolipoprotein B-100

APOB_HUMAN APOB

515,554

100.00%

2

2

4

0.48%

TGVKVDK TLLGDGPVVTDPK YVQHTYR ADEGISFR AEEFKK ATAVMPDGQFK DISLSDYK GLFIIDDK GLFIIDDKGILR IGHPAPNFK KQGGLGPMNIPLVSDPK LVQAFQFTDK QGGLGPMNIPLVSDPK QGGLGPMNIPLVSDPKR QITVNDLPVGR SVDETLR TIAQDYGVLK AVENSSTAIGIR DIREEAEK EEASNFR ESLKEEDESDDDNM HEIVPK HVGMAVAGLLADAR LYEEGSNKR SLADIAR SNFGYNIPLK VFQVEYAMK ADGSSLPEWVTDNAGTLHFAR DDVTGEEAR HPASEAEIQPQTQVTLR QPSSQDALQGR VFTAGSEER VVLAPQDVVVAR ELGSLPLPLSTSEQR QLEADILDVNQIFK IEGNLIFDPNNYLPK NLLVALK

95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0% 95.0%

35.2 73.8 37.0 59.6 30.6 58.5 37.4 47.4 53.2 45.3 54.7 67.5 108.0 62.5 82.9 53.7 60.4 92.8 39.4 45.5 77.1 34.8 81.5 48.6 31.3 58.0 57.8 37.8 48.7 29.8 47.2 35.6 48.0 37.3 45.5 31.6 41.8

22.4 20.9 22.1 22.6 23.1 22.6 21.6 20.5 15.6 21.7 18.2 21.2 22.0 19.6 21.0 24.7 21.7 23.2 22.9 21.0 8.5 19.9 21.8 21.4 25.5 22.3 21.9 22.0 15.9 22.5 21.8 21.3 14.5 20.8 21.1 21.7 12.0

1 15 5 12 1 19 5 11 9 1 3 54 17 3 23 2 14 11 4 4 14 3 6 4 1 12 10 0 2 0 4 1 3 1 1 2 2

0 0 0 0 0 0 0 0 5 0 1 0 0 3 0 0 0 0 0 0 0 0 8 0 0 0 0 1 0 2 0 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2

746.44 1,311.72 966.48 894.43 751.40 1,180.57 940.46 920.51 1,359.80 980.53 1,750.95 1,196.63 1,638.85 1,778.96 1,211.68 819.42 1,107.61 1,217.65 989.49 852.39 1,671.62 722.42 1,396.74 1,095.54 745.42 1,152.61 1,130.56 2,244.07 991.43 1,904.98 1,186.58 995.48 1,265.76 1,626.87 1,645.88 1,746.91 770.51

Table S1 page 159/159