27. 0.23. 0.01. 0.42. B. Clone name log2 ER mean log2 ER. Growth factor activity (3). Melanoma derived growth regulatory protein. 0.62. 0.46. Midkine precursor.
A Functional category Growth factor activity Sulfur metabolism Electrochemical potential-driven transporter activity Skeletal development G1 S transition of mitotic cell cycle Nucleotide metabolism Negative regulation of cell cycle Response to pathogen Protein-nucleus import Sugar binding Regulation of I-kappaB kinase NF-kappaB cascade DNA replication Calmodulin binding Blood coagulation Mitotic cell cycle Mitochondrial membrane Muscle contraction Protein kinase cascade Receptor binding Humoral immune response Cytoskeleton Endopeptidase activity Plasma membrane Apoptosis Structural constituent of ribosome Protein biosynthesis
Genes mean log2 ER 3 0.46 3 0.50 3 0.53 3 0.71 4 -0.99 4 -0.69 4 0.41 4 0.43 4 0.55 4 0.64 4 0.68 5 -0.56 5 0.43 5 0.68 6 -0.84 6 0.43 11 0.34 11 0.35 17 0.33 17 0.36 18 0.31 18 0.35 20 0.35 21 0.28 24 0.21 27 0.23
B Clone name Growth factor activity (3) Melanoma derived growth regulatory protein Midkine precursor Glucose-6-phosphate isomerase-2 Sulfur metabolism (3) Protein-tyrosine sulfotransferase 1 Dermatan-4-sulfotransferase-1-1 Dermatan-4-sulfotransferase-1-2 Electrochemical potential-driven transporter activity (3) Sodium/bile acid cotransporter 4F2 cell-surface antigen heavy chain ADP,ATP carrier protein T2 Skeletal development (3) Tumor necrosis factor receptor superfamily member 11B Chemokine 5a receptor-like Leukocyte cell-derived chemotaxin 2 G1/S transition of mitotic cell cycle (4) Vasopressin-activated calcium-mobilizing receptor Cyclin G1 Cdk inhibitor p21 binding protein G1/S-specific cyclin E1 Nucleotide metabolism (4)
log2 ER mean log2 ER 0.62 0.32 0.44
0.46
0.53 0.48 0.49
0.50
0.58 0.45 0.57
0.53
0.78 0.73 0.61
0.71
-1.41 -0.68 -0.66 -1.21
-0.99
p-value 0.03 0.00 0.01 0.00 0.01 0.05 0.01 0.00 0.02 0.02 0.01 0.01 0.00 0.01 0.03 0.05 0.04 0.02 0.02 0.04 0.02 0.03 0.01 0.03 0.01 0.01
SE 0.15 0.03 0.07 0.08 0.38 0.42 0.11 0.10 0.25 0.26 0.19 0.28 0.16 0.33 0.68 0.39 0.47 0.44 0.52 0.67 0.51 0.63 0.54 0.56 0.39 0.42
Transaldolase Adenosine deaminase 3 Triosephosphate isomerase Nucleoside diphosphate kinase, mitochondrial precursor Negative regulation of cell cycle (4) Interferon regulatory factor 1-1 Reversion-inducing cysteine-rich protein with Kazal motifs Retinoblastoma-like protein 1 Fumarate hydratase, mitochondrial precursor Response to pathogen (4) NF-kappaB inhibitor alpha-1 NACHT-, LRR- and PYD-containing protein 2 NF-kappaB inhibitor alpha-2 NF-kappaB inhibitor alpha-3 Protein-nucleus import (4) NF-kappaB inhibitor alpha-1 Proteinase activated receptor 1 NF-kappaB inhibitor alpha-2 NF-kappaB inhibitor alpha-3 Sugar binding (4) B-cell receptor CD22-1 C type lectin receptor B Galectin-3 Selectin L-like Regulation of I-kappaB kinase NF-kappaB cascade (4) Receptor-interacting serine/threonine-protein kinase 2 Proteinase activated receptor 1 Tumor necrosis factor receptor superfamily member 5 precursor Phosphotyrosine independent ligand for the Lck SH2 domain p62 DNA replication (5) Reverse transcriptase-like-1 ReO_6-3 Reverse transcriptase-like-2 Telomerase reverse transcriptase Ribonucleoside-diphosphate reductase large subunit Calmodulin binding (5) Regulator of G-protein signaling 1-1 Myristoylated alanine-rich protein kinase C substrate Myosin heavy chain, skeletal, adult 1-1 Myosin heavy chain, cardiac muscle beta isoform Myosin heavy chain, skeletal, adult 1-2 Blood coagulation (5) Proteinase activated receptor 1 Tumor necrosis factor receptor superfamily member 5 precursor Annexin 5 Coagulation factor X precursor Plasminogen precursor-1 Mitotic cell cycle (6) Vasopressin-activated calcium-mobilizing receptor Cyclin G1 G2/mitotic-specific cyclin B2 DnaJ homolog subfamily A member 2 Cdk inhibitor p21 binding protein G1/S-specific cyclin E1 Mitochondrial membrane (6) Voltage-dependent anion-selective channel protein 1
-0.71 -0.35 -1.28 -0.42
-0.69
0.34 0.58 0.40 0.34
0.41
0.48 0.43 0.29 0.53
0.43
0.48 0.90 0.29 0.53
0.55
0.44 0.97 0.43 0.74
0.64
0.44 0.90 0.75 0.65
0.68
-0.57 -0.29 -0.27 -0.79 -0.89
-0.56
0.23 0.34 0.41 0.63 0.53
0.43
0.90 0.75 0.33 0.36 1.08
0.68
-1.41 -0.68 -1.46 0.35 -0.66 -1.21
-0.84
-0.30
0.43
Cytochrome c oxidase subunit I-1 ADP,ATP carrier protein T2 Cytochrome c oxidase subunit I-2 39S ribosomal protein L45, mitochondrial precursor Cytochrome b-3 Muscle contraction (11) C3a anaphylatoxin chemotactic receptor Troponin T-3, fast skeletal muscle Fructose-bisphosphate aldolase A Actin, alpha skeletal 2 Actin, alpha skeletal 3 Myosin heavy chain, skeletal, adult 1-1 Tropomyosin alpha 3 chain-2 Myosin heavy chain, cardiac muscle beta isoform Troponin I-4, fast skeletal muscle Actin, alpha skeletal 4 Myosin heavy chain, skeletal, adult 1-2 Protein kinase cascade (11) Tyrosine-protein kinase ZAP-70 NF-kappaB inhibitor alpha-1 Receptor-interacting serine/threonine-protein kinase 2 Proteinase activated receptor 1 Tumor necrosis factor receptor superfamily member 5 precursor MAPK/ERK kinase kinase 6 Growth arrest and DNA-damage-inducible GADD45 beta Phosphotyrosine independent ligand for the Lck SH2 domain p62 NF-kappaB inhibitor alpha-2 Mitogen-activated protein kinase 13 NF-kappaB inhibitor alpha-3 Receptor binding (17) Tumor necrosis factor receptor superfamily member 11B Small inducible cytokine B14 precursor Alpha-taxilin Proteinase activated receptor 1 Glomulin Chemokine-like factor family member 3 Melanoma derived growth regulatory protein B-cell receptor-associated protein 31 Receptor for activated C kinase Heat shock protein 75 kDa-2 Midkine precursor CC chemokine SCYA110-2 Laminin alpha-4 chain precursor Glucose-6-phosphate isomerase-2 B-cell receptor-associated protein BAP37-2 T-cell receptor alpha chain V region HPB-MLT precursor (Fragment) Guanine nucleotide-binding protein beta subunit 2-like 1 Humoral immune response (17) B-cell receptor CD22-1 GRB2-related adaptor protein 2 Cytochrome B-245 heavy chain-1 Complement factor B/C2-B Tumor necrosis factor receptor superfamily member 5 precursor Complement component C9 Mannan-binding lectin serine protease 2-1 Complement factor MASP-3
0.84 0.57 0.35 0.66 0.44 -0.83 0.35 -0.18 0.34 0.39 0.41 0.87 0.63 0.62 0.59 0.53
0.34
-0.47 0.48 0.44 0.90 0.75 0.22 0.57 0.65 0.29 -0.44 0.53
0.35
0.78 0.34 -0.89 0.90 0.78 0.58 0.62 0.47 0.35 0.26 0.32 -0.38 -0.71 0.44 0.30 0.89 0.60
0.33
0.44 -0.16 0.87 1.08 0.75 0.51 -0.51 1.90
0.36
Coatomer epsilon subunit 1 Serine protease-like protein-1 Adenosine deaminase 3 Serine protease-like protein-3 CC chemokine SCYA110-2 Glucose-6-phosphate isomerase-2 Transferrin Complement factor H-1 Complement factor H-2 Cytoskeleton (18) PDZ and LIM domain protein 1 Coronin-1C Actin, cytoplasmic 2 Beta actin-2 Troponin T-3, fast skeletal muscle Chromosome-associated kinesin KIF4A Myristoylated alanine-rich protein kinase C substrate Thymosin beta-4-2 Myosin light chain 2-1 Microtubule-associated protein RP/EB Actin, alpha skeletal 2 Actin, alpha skeletal 3 Myosin heavy chain, skeletal, adult 1-1 Tropomyosin alpha 3 chain-2 Myosin heavy chain, cardiac muscle beta isoform Actin, alpha skeletal 4 Myosin heavy chain, skeletal, adult 1-2 Actin, alpha skeletal 5 Endopeptidase activity (18) Cathepsin B-2 Cathepsin D-1 Cathepsin Y Complement factor B/C2-B Cathepsin D-2 Mannan-binding lectin serine protease 2-1 Matrix metalloproteinase-2 ADAMTS-3 Complement factor MASP-3 Tolloid-like protein (nephrosin)-1 Serine protease-like protein-1 Cathepsin C-2 Serine protease-like protein-3 Proteasome subunit alpha type 6 Proteasome subunit alpha type 7-1 Transferrin Coagulation factor X precursor Plasminogen precursor-1 Plasma membrane (20) Chemokine 5a receptor-like C3a anaphylatoxin chemotactic receptor B-cell receptor CD22-1 Tumor necrosis factor receptor superfamily member 9 Galectin-3 Proteinase activated receptor 1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 Tumor necrosis factor receptor superfamily member 5 precursor
-0.42 -0.44 -0.35 0.35 -0.38 0.44 0.48 0.44 1.06 0.52 -1.18 0.52 0.62 0.35 0.34 0.34 -0.28 0.52 -0.62 0.34 0.39 0.41 0.87 0.63 0.59 0.53 0.69
0.31
0.33 0.35 -0.34 1.08 0.53 -0.51 0.29 0.40 1.90 0.76 -0.44 -0.31 0.35 0.59 -0.53 0.48 0.36 1.08
0.35
0.73 -0.83 0.44 0.71 0.43 0.90 -0.28 0.75
0.35
CD63 Complement component C9 Fibronectin receptor beta Regulator of G-protein signaling 1-1 Vesicle-associated membrane protein-associated protein B/C B-cell receptor-associated protein 31 Tolloid-like protein (nephrosin)-1 Ferritin heavy chain-1 Na/K ATPase alpha subunit-1 MIR-interacting saposin-like protein precursor T-cell receptor alpha chain V region HPB-MLT precursor (Fragment) Myristoylated alanine-rich protein kinase C substrate Apoptosis (21) Tumor necrosis factor receptor superfamily member 11B NF-kappaB inhibitor alpha-1 TNF decoy receptor Tumor necrosis factor receptor superfamily member 9 NACHT-, LRR- and PYD-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 Proteinase activated receptor 1 Voltage-dependent anion-selective channel protein 1 BCL2/adenovirus E1B 19-kDa protein-interacting protein 2 Tumor necrosis factor receptor superfamily member 5 precursor Inhibitor of apoptosis protein 3 BCL2-associated athanogene 1 Growth arrest and DNA-damage-inducible GADD45 beta Vasopressin-activated calcium-mobilizing receptor TNF receptor associated factor 1 Cold autoinflammatory syndrome 1 protein Ubiquitin ligase SIAH1 NF-kappaB inhibitor alpha-2 B-cell receptor-associated protein 31 NF-kappaB inhibitor alpha-3 Nuclear protein 1 Structural constituent of ribosome (24) 60S ribosomal protein L5-1 Ribosomal protein L6-1 Mitochondrial ribosomal protein L4, isoform a 40S ribosomal protein S14 (PRO2640) Ribosomal protein L11 60S ribosomal protein L7a-2 60S ribosomal protein L10-1 40S ribosomal protein S20 40S ribosomal protein S11 60S ribosomal protein L36 Ribosomal protein S2 40S ribosomal protein S15-2 TGF beta-inducible nuclear protein 1 Ubiquitin 39S ribosomal protein L45, mitochondrial precursor 28S ribosomal protein S16, mitochondrial precursor 60S ribosomal protein L18 60S ribosomal protein L32-2 60S ribosomal protein L7 40S ribosomal protein S3-1 40S ribosomal protein S9-1
0.43 0.51 0.74 0.23 -1.15 0.47 0.76 0.41 0.21 0.39 0.89 0.34 0.78 0.48 0.48 0.71 0.43 0.44 0.90 -0.30 0.30 0.75 -0.88 0.30 0.57 -1.41 0.58 0.45 -0.27 0.29 0.47 0.53 0.34
0.28
-0.39 0.80 -0.46 -0.18 -0.25 0.47 0.28 -0.60 0.28 -0.15 0.45 0.40 0.55 0.34 0.66 0.67 0.50 0.22 0.29 0.33 -0.23
0.21
40S ribosomal protein S6 Ribosomal protein L13 Ribosomal protein L6-2 Protein biosynthesis (27) Glomulin Mitogen-activated protein kinase 13 Basic leucine-zipper protein BZAP45-1 Alpha-2,8-sialyltransferase 8F 60S ribosomal protein L5-1 Ribosomal protein L6-1 Mitochondrial ribosomal protein L4, isoform a 40S ribosomal protein S14 (PRO2640) 60S ribosomal protein L7a-2 Eukaryotic translation elongation factor 1 alpha 1 60S ribosomal protein L10-1 40S ribosomal protein S20 40S ribosomal protein S11 60S ribosomal protein L36 Ribosomal protein S2 TGF beta-inducible nuclear protein 1 Ubiquitin 39S ribosomal protein L45, mitochondrial precursor Eukaryotic translation initiation factor 3 subunit 6-2 28S ribosomal protein S16, mitochondrial precursor 60S ribosomal protein L18 60S ribosomal protein L7 40S ribosomal protein S3-1 40S ribosomal protein S9-1 Ribosomal protein L13 Elongation factor 1-alpha 2 Ribosomal protein L6-2
0.33 0.28 0.50 0.78 -0.44 0.57 -0.42 -0.39 0.80 -0.46 -0.18 0.47 0.45 0.28 -0.60 0.28 -0.15 0.45 0.55 0.34 0.66 0.31 0.67 0.50 0.29 0.33 -0.23 0.28 0.50 0.50
0.23
