additional data file 2

Additional data file 2. Genes regulated by Hfe disruption in D2 and/or B6 duodenum. Cluster 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A

ProbesetID 1437286_x_at 1439678_at 1437285_at 1428236_at 1435494_s_at 1440005_at 1455232_at 1452942_at 1434657_at 1445870_at 1429108_at 1437287_at 1444980_at 1422450_at 1445824_at 1434329_s_at 1452679_at 1449459_s_at 1425314_at 1439568_at 1437333_x_at 1415941_s_at 1439999_at 1416980_at 1434061_at 1418429_at 1437325_x_at 1415836_at 1448470_at 1441930_x_at 1460370_at 1445128_at 1460444_at 1457731_at 1418505_at 1429347_at 1433831_at 1459860_x_at

Genbank BB277742 BM239869 BB277742 AK005001 AV297961 BB667396 BB745660 BF383782 BE983473 BB367621 BB745314 BB277742 BE996518 NM_007615 AV276001 BG074607 AA986082 AF403041 AF435926 AV373997 BB833010 NM_133349 BB432092 NM_027853 BB431808 BI328541 BB251523 NM_019698 NM_019395 BB089991 AF362952 BQ176646 AK004614 BB247595 NM_027722 AK016670 BM213879 BB466780

Gene symbol 1110020G09Rik Gls 1110020G09Rik Acbd5 Dsp C730009D12 Cml2 Tmem65 AI314027 Cdc42ep2 Msl2l1 1110020G09Rik C730009D12 Ctnnd1 Zfp458 Adipor2 Tubb2b Asb13 Gpr98 Greb1 Aldh18a1 Zfand2a

Description RIKEN cDNA 1110020G09 gene glutaminase RIKEN cDNA 1110020G09 gene acyl-Coenzyme A binding domain containing 5 desmoplakin

Mettl7b Rp2h Kif5b Aldh18a1 Aldh18a1 Fbp1 Vat1 Top1mt

methyltransferase like 7B retinitis pigmentosa 2 homolog (human) kinesin family member 5B aldehyde dehydrogenase 18 family, member A1 aldehyde dehydrogenase 18 family, member A1 fructose bisphosphatase 1 vesicle amine transport protein 1 homolog (T californica) DNA topoisomerase 1, mitochondrial

Arrb1 Psip1 Nudt4 Bcl2l14 4833418A01Rik Trim2

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

A A A A A A A A A A A A A A A A A

1448415_a_at 1420821_at 1417319_at 1451271_a_at 1434193_at 1440051_at 1436737_a_at 1434853_x_at 1436994_a_at 1426675_at 1419401_at 1438442_at 1432946_at 1436915_x_at 1455285_at 1439406_x_at 1427944_at

NM_009153 NM_030750 NM_021495 BG070487 AV122561 BB467915 BB737680 AA717142 BB533903 BB225670 AF403041 AI450236 AK017228 AU024771 BB771765 BB530332 BE951890

Sema3b Sgpp1 Pvrl3 Acat1 Zmym6 Ppp3ca Sorbs1 Mkrn1 Hist1h1c Tomm70a Asb13 AI450236 5230400M06Rik Laptm4b Slc31a1 Fars2 C1qdc1

arrestin, beta 1 PC4 and SFRS1 interacting protein 1 nudix (nucleoside diphosphate linked moiety X)-type motif 4 Bcl2-like 14 (apoptosis facilitator) RIKEN cDNA 4833418A01 gene tripartite motif protein 2 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B sphingosine-1-phosphate phosphatase 1 poliovirus receptor-related 3 acetyl-Coenzyme A acetyltransferase 1 zinc finger, MYM-type 6 protein phosphatase 3, catalytic subunit, alpha isoform sorbin and SH3 domain containing 1 makorin, ring finger protein, 1 histone 1, H1c translocase of outer mitochondrial membrane 70 homolog A (yeast) ankyrin repeat and SOCS box-containing protein 13 expressed sequence AI450236 RIKEN cDNA 5230400M06 gene lysosomal-associated protein transmembrane 4B solute carrier family 31, member 1 phenylalanine-tRNA synthetase 2 (mitochondrial) C1q domain containing 1

camello-like 2 transmembrane protein 65 expressed sequence AI314027 CDC42 effector protein (Rho GTPase binding) 2 male-specific lethal 2-like 1 (Drosophila) RIKEN cDNA 1110020G09 gene catenin (cadherin associated protein), delta 1 zinc finger protein 458 adiponectin receptor 2 tubulin, beta 2b ankyrin repeat and SOCS box-containing protein 13 G protein-coupled receptor 98 gene regulated by estrogen in breast cancer protein aldehyde dehydrogenase 18 family, member A1 zinc finger, AN1-type domain 2A

D2KOvsD2WT 4,04 4,80 3,63 3,20 3,41 3,02 3,42 3,53 2,80 2,97 3,19 3,30 2,81 2,79 2,57 2,46 2,66 2,65 2,41 2,64 2,42 2,55 2,68 2,46 2,44 2,56 2,49 2,58 2,36 2,57 2,40 2,54 2,78 2,31 2,71 2,19 2,38 2,36

B6KOvsB6WT -1,10 -0,40 -0,65 -0,98 0,16 -1,48 -0,27 -0,34 -0,60 -0,59 -0,40 -0,47 -1,48 0,02 -0,34 -1,18 -1,34 -0,35 -0,65 -0,69 -0,98 -0,56 -0,19 -0,62 -0,58 -0,81 -1,34 -0,63 -1,67 -0,84 -0,65 -1,95 -0,87 -0,14 0,38 -0,01 -0,45 -1,52

2,71 2,41 2,35 2,52 2,09 2,27 2,29 2,22 2,35 2,39 2,21 2,38 2,05 2,20 2,18 2,21 2,66

0,19 -2,08 -0,85 -0,74 -0,30 -0,70 -0,83 -0,58 -1,90 -1,21 -0,29 -0,68 0,23 -1,03 0,31 -0,68 -0,47

D2WTvsB6WT Chromosome Position (kb) -0,56 15 8 998 562 -0,53 1 -0,35 15 8 998 562 -0,61 2 22 891 457 -0,43 13 -1,15 18 -0,32 6 85 831 056 -1,09 15 58 612 352 -0,71 1 0,21 19 5 917 560 0,10 9 -0,52 15 8 998 562 -0,89 18 -0,94 2 84 401 621 0,20 13 67 754 015 0,51 6 119 318 770 0,33 13 34 134 472 -0,51 13 3 633 323 0,85 13 81 558 503 -1,06 12 16 697 104 -0,28 19 40 603 567 -1,16 5 139 724 858 -1,45 10 98 456 397 -1,14 10 128 361 225 -0,84 X 19 521 566 -1,72 18 6 202 229 -0,29 19 40 603 567 0,25 19 40 603 567 -1,54 13 62 874 376 -1,06 11 101 274 837 -0,09 15 75 484 288 -0,01 9 96 877 535 -0,17 7 99 409 568 -0,98 4 82 926 910 -1,23 10 94 976 976 -1,13 6 134 362 021 -0,11 2 70 856 690 -1,73 3 84 246 371 -1,00 -1,78 -1,32 -0,70 -1,18 -0,02 -0,24 -0,95 -1,05 -0,12 -0,42 0,24 -1,07 -1,27 -1,25 -1,00 -0,73

9 12 16 9 4 3 19 6 13 16 13 3 14 15 4 13 6

107 456 215 76 633 106 46 367 420 53 342 916 126 579 686 136 608 156 40 345 351 39 327 426 23 746 271 57 043 072 3 633 323 103 136 225 34 182 616 61 847 109 36 124 875

1 1 1 1 1 1

A A A A A A

1416131_s_at 1432156_a_at 1452654_at 1447693_s_at 1425537_at 1452700_s_at

BB188557 AK012288 BB224658 BB350308 AF259672 AK003597

C920006C10Rik Rnf32 Zdhhc2 Neo1 Ppm1a Kbtbd7

2,05 2,33 2,16 2,09 2,07 2,14

-1,09 -0,57 -0,81 -1,20 -1,00 -0,50

-1,73 -0,90 -0,51 -0,71 -0,54 0,00

15 5 8 9 12 14

65 616 730 29 526 864 41 922 631 58 672 818 73 680 441 78 160 665

Ywhaq Ppp1cb Cdc14a Cpox Tinag Tpmt Lbh Acsl6 Ceacam18

RIKEN cDNA C920006C10 gene ring finger protein 32 zinc finger, DHHC domain containing 2 neogenin protein phosphatase 1A, magnesium dependent, alpha isoform kelch repeat and BTB (POZ) domain containing 7 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide protein phosphatase 1, catalytic subunit, beta isoform CDC14 cell division cycle 14 homolog A (S. cerevisiae) coproporphyrinogen oxidase tubulointerstitial nephritis antigen thiopurine methyltransferase limb-bud and heart acyl-CoA synthetase long-chain family member 6 CEA-related cell adhesion molecule 1

1 1 1 1 1 1 1 1 1

A A A A A A A A A

1432842_s_at 1433540_x_at 1436913_at 1422492_at 1419314_at 1456273_x_at 1429088_at 1451257_at 1430927_at

AK012300 AW823525 BB479310 BG067254 BC010745 BB744467 AK007400 BC022959 AK008389

2,18 2,01 2,24 2,02 2,12 2,08 2,23 2,09 2,18

0,14 -0,57 -0,18 0,09 -0,01 -1,01 -0,41 -0,83 -0,18

-0,99 -1,00 -1,03 0,13 -0,48 -0,19 -0,54 1,20 -1,52

12 5 3 16 9 13 17 11 7

21 636 820 32 735 840 116 264 540 58 612 834 76 737 606 47 036 150 72 823 325 54 147 626 43 502 780

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

A A A A A A A A A A A A A A A B B B B B B B B B

1449382_at 1443115_at 1450717_at 1439638_at 1459143_at 1421052_a_at 1427035_at 1456712_at 1439065_x_at 1438050_x_at 1428643_at 1447567_at 1415937_s_at 1429146_at 1454870_x_at 1450380_at 1421815_at 1449492_a_at 1451139_at 1460604_at 1460329_at 1450627_at 1444266_at 1459314_at

NM_133661 BB465968 NM_007447 BB336138 BB667403 NM_009214 BB399837 AV231984 C77501 BG966742 AK015544 BM118129 BC026823 BF011349 BB251205 AF353717 AF353717 NM_010702 BC023498 BE945607 BG066773 NM_020332 AI851612 BB229373

Slc6a12 Tgfbr2 Ang1 Erbb2ip Chchd3 Sms Slc39a14 Lcorl C230078M14Rik Tspan12 Mgat5 Odz3 Pdcd6ip 6620401M08Rik Gpr172b Epdr2 Epdr2 Lect2 Slc39a4 Cybrd1 B4galt6 Ank Hod Cdkal1

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 transforming growth factor, beta receptor II angiogenin, ribonuclease A family, member 1 Erbb2 interacting protein coiled-coil-helix-coiled-coil-helix domain containing 3 spermine synthase solute carrier family 39 (zinc transporter), member 14 ligand dependent nuclear receptor corepressor-like RIKEN cDNA C230078M14Rik gene tetraspanin 12 mannoside acetylglucosaminyltransferase 5 odd Oz/ten-m homolog 3 (Drosophila) programmed cell death 6 interacting protein RIKEN cDNA 6620401M08 gene G protein-coupled receptor 172B ependymin related protein 2 (zebrafish) ependymin related protein 2 (zebrafish) leukocyte cell-derived chemotaxin 2 solute carrier family 39 (zinc transporter), member 4 cytochrome b reductase 1 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 progressive ankylosis homeobox only domain CDK5 regulatory subunit associated protein 1-like 1

2,05 2,05 2,13 2,07 2,04 2,24 2,12 2,06 2,14 2,02 2,06 2,04 2,04 2,37 2,15 6,97 6,30 5,65 4,87 2,97 3,67 3,66 2,85 2,98

-0,19 -0,13 0,03 -1,13 -0,89 -0,02 0,10 -1,27 -1,21 -0,35 -0,71 -0,43 -1,27 -1,87 -0,08 1,28 1,25 0,75 2,52 0,59 0,91 1,08 1,48 -0,10

-0,16 -0,21 -0,50 -1,32 -0,64 0,17 -0,87 -1,71 0,66 0,67 0,21 -0,53 -0,98 -1,13 -1,07 1,09 0,99 0,15 0,93 -0,87 -1,44 0,23 0,56 0,19

6 9 14 13 6 X 14 5 1 6 1 8 9 7 15 13 13 13 15 2 18 15 5 13

121 312 322 115 936 404 50 018 363 104 939 168 32 722 384 152 788 058 69 038 548 45 987 943 101 927 911 21 721 395 129 134 307 49 726 507 113 503 632 51 865 094 76 366 197 19 599 170 19 599 170 56 552 088 76 439 638

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

B B B B B B B B B B B B B B B B B B B

1457404_at 1455037_at 1425040_at 1450882_s_at 1425002_at 1435708_at 1449670_x_at 1452203_at 1417329_at 1439361_at 1434599_a_at 1427008_at 1457756_at 1446483_at 1437892_at 1450913_at 1436556_at 1421108_at 1434129_s_at

BM240058 BB002869 AF354666 AK010724 BC010462 BB355415 AW546472 AV313559 NM_018824 BG797614 BB758095 BC004781 BB483373 AV236736 BQ084812 BG066773 BB534983 NM_053096 BG917242

Nfkbiz Plxna2 Cybrd1 Gpr137b BC010462 Gls Gpr137b 5830411E10Rik Slc23a2 Myo9a Tjp2 Rnf43 Zfp192 Akr1e1 Zfp306 B4galt6 Tmem139 Cml2 Lhfpl2

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta plexin A2 cytochrome b reductase 1 G protein-coupled receptor 137B cDNA sequence BC010462 glutaminase G protein-coupled receptor 137B RIKEN cDNA 5830411E10 gene solute carrier family 23 (nucleobase transporters), member 2 myosin IXa tight junction protein 2 ring finger protein 43 zinc finger protein 192 aldo-keto reductase family 1, member E1 zinc finger protein 306 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 transmembrane protein 139 camello-like 2 lipoma HMGIC fusion partner-like 2

2,98 3,11 2,63 2,79 2,98 3,03 2,53 2,55 2,91 2,50 2,60 2,71 2,60 2,48 2,61 3,17 2,85 2,66 2,68

0,31 0,55 0,94 2,52 0,96 -0,09 1,75 0,92 0,81 0,94 0,45 0,50 2,27 0,25 0,78 1,27 1,94 0,51 0,10

-0,57 0,55 0,18 0,04 0,31 0,17 -0,38 0,28 -0,82 0,14 0,41 -1,15 0,42 0,46 -0,87 -0,71 -1,33 0,48 -0,28

16 1 2 13 11 1 13 1 2 9 19 11 13 13 13 18 6 6 13

55 736 328 196 320 644

20 829 012 27 411 401 78 161 765 29 332 772

12 670 181 120 883 492 12 670 181 51 413 234 131 743 937 24 161 607 87 516 091 21 520 686 4 591 737 21 394 560 20 829 012 42 191 565 85 831 056 95 158 548

1 B 1451600_s_at

BC019147

LOC13909

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

B B B B B B B B B B B B B B B B B B B B B B B B B B B B

1445629_at 1421161_at 1417593_at 1417649_at 1453422_a_at 1431356_at 1439255_s_at 1456927_at 1421312_a_at 1428527_at 1438074_at 1437378_x_at 1441794_at 1428662_a_at 1447411_at 1431960_at 1439342_at 1419734_at 1417559_at 1416252_at 1460684_at 1445589_at 1445062_at 1448689_at 1457673_at 1434846_at 1429847_a_at 1417403_at

AI642520 NM_007568 NM_019742 NM_009876 AK003858 AK019889 BB726971 BB367890 NM_010630 AK011015 AU024481 BB224405 BB797041 AK009007 AI506883 AK019911 AV353028 NM_007393 BB478992 NM_134115 BC014769 BM940232 BB457876 NM_025846 AI643819 AW557010 AK014717 NM_130450

Slc35d1 Btc Tusc2 Cdkn1c 1110020G09Rik 6430710C18Rik Gpr137b Mast2 Kifc2 Snx7 2210010C17Rik Scarb1 4933437K13Rik Hod Ugdh Wwox Clpx Actb Sfxn1 Stk38 Tm7sf2 Slc23a2 Elovl6 Rras2 2610005L07Rik 1700065A05Rik 4833418A01Rik Elovl6

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

B B B B B B B B B B B B B C C C C C C C C C C C C C C C C C

1428821_at 1421340_at 1427910_at 1452213_at 1432918_at 1444182_at 1424183_at 1424779_at 1424865_at 1424167_a_at 1450787_at 1436753_at 1452353_at 1438294_at 1430274_a_at 1455901_at 1422493_at 1457619_at 1417040_a_at 1428851_at 1424780_a_at 1440584_at 1424781_at 1437864_at 1416645_a_at 1438937_x_at 1428921_at 1433976_at 1427374_at 1451588_at

AK010891 NM_008580 AK003744 BM239615 AK014868 AV376910 BG070487 AK005026 BC010821 BC006809 NM_016691 BB317588 BB762731 BG067317 AK018331 AI642069 BG067254 BB743970 NM_016778 AK005003 AK005026 AV377077 AK005026 BE632137 NM_007423 AI385586 AK021189 BI249740 AF027131 BC014724

Agpat2 Map3k5 Cst6 Tex2 4921511E18Rik 2210010C17Rik Acat1 D10Ucla1 Pyy Pmm1 Clcn5 Adck5 Gpr155 Atxn1 Stard3nl Chpt1 Cpox Ces6 Bok 1300014I06Rik D10Ucla1 9130221L21Rik D10Ucla1 Adipor2 Afp Rnase4 2810021B07Rik D10Ucla1 Muc3 1810022C23Rik

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 betacellulin, epidermal growth factor family member tumor suppressor candidate 2 cyclin-dependent kinase inhibitor 1C (P57) RIKEN cDNA 1110020G09 gene RIKEN cDNA 6430710C18 gene G protein-coupled receptor 137B microtubule associated serine/threonine kinase 2 kinesin family member C2 sorting nexin 7 RIKEN cDNA 2210010C17 gene scavenger receptor class B, member 1 RIKEN cDNA 4933437K13 gene homeobox only domain UDP-glucose dehydrogenase WW domain-containing oxidoreductase caseinolytic peptidase X (E.coli) actin, beta, cytoplasmic sideroflexin 1 serine/threonine kinase 38 transmembrane 7 superfamily member 2 solute carrier family 23 (nucleobase transporters), member 2 ELOVL family member 6, elongation of long chain fatty acids (yeast) related RAS viral (r-ras) oncogene homolog 2 RIKEN cDNA 2610005L07 gene RIKEN cDNA 1700065A05 gene RIKEN cDNA 4833418A01 gene ELOVL family member 6, elongation of long chain fatty acids (yeast) 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) mitogen activated protein kinase kinase kinase 5 cystatin E/M testis expressed gene 2 RIKEN cDNA 4921511E18 gene RIKEN cDNA 2210010C17 gene acetyl-Coenzyme A acetyltransferase 1 DNA segment, Chr 10, University of California at Los Angeles 1 peptide YY phosphomannomutase 1 chloride channel 5 aarF domain containing kinase 5 G protein-coupled receptor 155 ataxin 1 STARD3 N-terminal like choline phosphotransferase 1 coproporphyrinogen oxidase carboxylesterase 6 Bcl-2-related ovarian killer protein RIKEN cDNA 1300014I06 gene DNA segment, Chr 10, University of California at Los Angeles 1 RIKEN cDNA 9130221L21 gene DNA segment, Chr 10, University of California at Los Angeles 1 adiponectin receptor 2 alpha fetoprotein ribonuclease, RNase A family 4 RIKEN cDNA 2810021B07 gene DNA segment, Chr 10, University of California at Los Angeles 1 mucin 3, intestinal RIKEN cDNA 1810022C23 gene

2,50

0,22

0,66

8

107 972 898

2,28 2,49 2,27 2,26 2,56 2,15 2,39 2,31 2,20 2,49 2,19 2,24 2,33 2,28 2,20 2,02 2,06 2,24 2,26 2,27 2,34 2,22 2,23 2,44 2,08 2,58 2,14 2,23

1,30 0,40 0,45 0,79 0,30 0,20 1,92 0,00 0,20 1,35 0,70 0,74 0,78 0,84 0,77 0,26 1,04 1,14 -0,05 0,65 0,71 2,86 2,01 0,44 -0,07 0,33 0,90 1,12

-0,31 0,02 -0,02 -0,68 0,42 -0,11 0,09 -0,66 -0,53 -0,27 1,37 -1,05 -0,09 -0,06 -1,30 -0,73 0,36 0,99 0,73 -0,60 0,39 0,77 -0,40 0,36 1,00 -0,52 0,74 -0,34

4 5 9 7 15 2 13 4 15 3 7 5 16 5 5 8 9 5 13 17 19 2 3 7 8 4 2 3

102 669 649 92 432 460 107 421 355 143 267 729 8 998 562

2,26 2,00 2,07 2,03 2,04 2,20 2,23 2,08 2,08 2,05 2,00 2,25 2,01 5,06 3,95 3,73 3,68 3,62 3,19 3,06 3,07 3,12 2,88 3,24 3,10 3,01 3,01 2,65 3,40 2,60

0,58 0,05 0,63 0,09 1,62 0,58 0,41 1,33 0,73 0,53 0,92 1,51 0,63 0,27 -1,24 -1,32 0,29 1,45 0,02 -0,02 -0,63 -1,57 -0,11 -0,12 0,22 -0,16 0,55 -0,31 0,02 -0,04

-0,94 -0,28 -0,65 -0,77 0,27 -0,72 0,23 -0,97 -0,32 -1,55 -0,15 -0,55 0,08 -4,36 -3,20 -3,47 -2,43 -2,62 -3,15 -2,53 -2,38 -3,56 -2,30 -3,50 -4,68 -6,12 -1,78 -2,65 -4,15 -1,90

2 10 19 11 X 7 9 10 11 15 X 15 2 13 13 10 16 8 1 13 10 13 10 6 5 14 13 10 5 13

12 670 181 115 804 694 76 487 910 117 773 499 19 095 826 125 566 070 11 319 225 78 161 765 65 692 358 117 325 672 65 092 314 143 168 255 54 081 498 28 698 475 6 062 821 131 743 937 129 524 407 113 837 968 20 272 528 70 856 690 129 524 407 26 415 595 19 623 898 5 344 704 106 318 229 19 095 826 53 342 916 66 406 864 101 922 766 81 778 366 6 316 433 76 403 613 45 565 864 19 365 142 87 903 332 58 612 834 107 623 136 95 516 107 34 635 304 66 406 864 66 406 864 119 318 770 91 565 936 50 013 146 17 480 554 66 406 864 34 954 078

1 1 1 1

C C C C

1425099_a_at 1422914_at 1429555_at 1421037_at

BC011080 NM_022435 AA408371 BG070037

Arntl Sp5 Cldnd1 Npas2

aryl hydrocarbon receptor nuclear translocator-like trans-acting transcription factor 5 claudin domain containing 1 neuronal PAS domain protein 2

2,79 2,94 2,49 3,00

0,93 0,32 -0,63 -0,89

-2,62 -4,39 -2,59 -3,17

7 2 16 1

112 998 645 70 275 761 58 670 586 39 138 757

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

C C C C C C C C C C C C C C C C C C C C D D D D D D D D D D D D

1460232_s_at 1433527_at 1416267_at 1424649_a_at 1447227_at 1456789_at 1436848_x_at 1428252_at 1435446_a_at 1443078_at 1460203_at 1448612_at 1433741_at 1434387_at 1420809_a_at 1434754_at 1437918_at 1431293_a_at 1437595_at 1431833_a_at 1456573_x_at 1449316_at 1460194_at 1416105_at 1435691_at 1447439_at 1449076_x_at 1428973_s_at 1419072_at 1451461_a_at 1416776_at 1439143_at

NM_013821 BB080732 NM_019708 BC025461 AI504711 AW491540 AV348702 AA881383 BF180212 AV321994 NM_010585 NM_018754 BB256012 AV251853 NM_019769 AU067654 AV374644 AK012260 BB531414 AK004902 BB205930 NM_134127 NM_010726 BC008518 BB209207 AI848394 NM_134052 AK007178 NM_026672 BC008184 NM_016669 BB312992

Hsd3b6 Ireb2 Scoc Tspan8 Slc40a1 Zfp462 Impa1 Chmp2b Chpt1 6030439D06Rik Itpr1 Sfn Cd38 Itfg3 1500003O03Rik Garnl4 4930539E08Rik Cldnd1 E030010A14Rik Hmgcs2 Nnt Cyp4f15 Phyh Nnt C630028N24Rik 1700023E05Rik Adi1 0610012D17Rik Gstm7 Aldoc Crym 9310367 E06

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 iron responsive element binding protein 2 short coiled-coil protein tetraspanin 8 solute carrier family 40 (iron-regulated transporter), member 1 zinc finger protein 462 inositol (myo)-1(or 4)-monophosphatase 1 chromatin modifying protein 2B choline phosphotransferase 1 RIKEN cDNA 6030439D06 gene inositol 1,4,5-triphosphate receptor 1 stratifin CD38 antigen integrin alpha FG-GAP repeat containing 3 RIKEN cDNA 1500003O03 gene GTPase activating RANGAP domain-like 4 RIKEN cDNA 4930539E08 gene claudin domain containing 1 RIKEN cDNA E030010A14 gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 nicotinamide nucleotide transhydrogenase cytochrome P450, family 4, subfamily f, polypeptide 15 phytanoyl-CoA hydroxylase nicotinamide nucleotide transhydrogenase RIKEN cDNA C630028N24 gene RIKEN cDNA 1700023E05 gene acireductone dioxygenase 1 RIKEN cDNA 0610012D17 gene glutathione S-transferase, mu 7 aldolase 3, C isoform crystallin, mu

2,66 2,26 2,38 2,06 2,14 2,10 2,20 2,11 2,22 2,07 2,07 2,16 2,02 2,03 2,10 2,08 2,14 2,44 2,45 2,15 4,69 4,46 3,77 3,27 2,64 2,80 2,21 2,47 2,17 2,26 2,15 2,14

0,05 -0,06 -0,99 -0,28 -0,33 -0,66 -1,25 -0,24 -0,33 -1,71 0,28 0,75 0,55 0,34 -1,07 0,03 -1,64 -1,75 1,19 0,55 -0,54 0,92 1,01 -0,04 -0,12 1,74 -0,79 -0,84 0,41 0,59 -1,31 -0,31

-3,86 -2,64 -4,52 -1,96 -2,80 -2,69 -3,85 -1,91 -2,58 -2,78 -2,69 -2,33 -3,60 -2,02 -2,10 -2,23 -3,85 -3,76 -4,98 -1,80 5,01 2,71 2,34 6,09 1,66 1,97 2,78 3,29 1,79 3,67 3,06 2,57

3 9 8 10 1 4 3 16 10 8 6 4 5 17 2 11 17 16 19 3 13 17 2 13 9 5 12 16 3 11 7 14

98 934 565 54 661 925 86 324 599 115 221 393 45 852 629 55 041 276 10 296 071 65 457 392 87 903 332 118 573 703 108 178 894 132 872 631 44 157 097 25 940 312 119 239 147 74 199 678 28 623 985 58 670 586 24 741 104 98 365 839 120 453 189 32 424 968 4 836 302 120 453 189 54 715 419 78 090 797 29 261 474 32 339 490 108 054 386 78 140 392 119 977 532

1 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

D _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

1441709_at 1442151_at 1422645_at 1443137_at 1426464_at 1442513_at 1418580_at 1435529_at 1457053_at 1436562_at 1450783_at 1421008_at 1426440_at 1422903_at 1418293_at 1451777_at 1426454_at 1453196_a_at 1455132_at 1437176_at 1438676_at 1434449_at 1436312_at

BB771579 BM238456 AJ306425 BB534298 W13191 AU041573 BC024872 BM245961 BB056354 BG063981 NM_008331 BB741897 AK009385 NM_010745 NM_008332 BC013672 AK002516 BQ033138 AV312663 AV277444 BM241485 BB193413 AV317621

Slc11a2 D230040A04Rik Hfe

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 RIKEN cDNA D230040A04 gene hemochromatosis nuclear receptor subfamily 1, group D, member 1 cDNA sequence BC016423 receptor transporter protein 4 RIKEN cDNA 2010002M12 gene cDNA sequence BC016423 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 interferon-induced protein with tetratricopeptide repeats 1 radical S-adenosyl methionine domain containing 2 dehydrogenase/reductase (SDR family) member 7 lymphocyte antigen 86 interferon-induced protein with tetratricopeptide repeats 2 cDNA sequence BC013672 Rho, GDP dissociation inhibitor (GDI) beta 2'-5' oligoadenylate synthetase-like 2 RIKEN cDNA A430107D22 gene expressed sequence AI451557 macrophage activation 2 like aquaporin 4 zinc finger protein, subfamily 1A, 1 (Ikaros)

0,62 -4,80 -7,32 -2,92 -2,20 1,03 -0,03 0,22 -0,12 0,88 -0,28 0,65 -0,40 -0,28 0,95 -0,37 -0,17 -0,22 -0,56 0,80 0,92 -1,06 -0,71

1,52 0,97 0,05 -1,36 1,38 0,24 1,43 2,08 0,63 1,12 1,80 2,31 -0,52 0,88 1,79 1,39 0,87 0,87 1,26 1,08 1,62 1,93 1,52

15 13 13 ? 11 13 16 19 13 4 19 12 12 13 19 8 6 5 17 8 5 18 11

100 215 935 13 860 001 23 711 307

Nr1d1 BC016423 Rtp4 2010002M12Rik BC016423 Ddx58 Ifit1 Rsad2 Dhrs7 Ly86 Ifit2 BC013672 Arhgdib Oasl2 A430107D22Rik AI451557 Mpa2l Aqp4 Zfpn1a1

2,04 -5,04 -5,70 -3,73 -2,53 -4,30 -4,22 -3,50 -3,09 -3,22 -2,92 -2,97 -2,81 -2,57 -2,79 -2,61 -2,61 -2,39 -2,28 -2,36 -2,23 -2,82 -2,63

98 584 024 23 525 275 34 683 047 40 394 460 34 706 885 27 029 020 73 569 193 37 352 810 34 616 942 64 886 557 136 887 904 115 157 934 97 414 195 105 455 208 15 535 849 11 586 215

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

1416246_a_at 1438037_at 1452544_x_at 1450981_at 1424518_at 1417699_at 1417190_at 1417793_at 1450484_a_at 1439114_at 1429564_at 1417056_at 1419697_at 1424181_at 1418191_at 1449556_at 1451306_at 1426596_a_at 1436058_at 1433963_a_at 1451787_at 1422257_s_at 1425645_s_at 1445411_at 1454268_a_at 1422120_at 1438024_at 1428393_at 1422660_at 1417104_at 1449410_a_at 1427119_at 1437180_at 1451358_a_at 1460121_at 1416235_at 1435737_a_at 1416035_at 1416927_at 1425151_a_at 1448310_at 1421420_at 1416961_at 1460681_at 1457350_at 1430127_a_at 1419423_at 1423746_at 1426004_a_at 1423090_x_at 1429672_at 1460682_s_at 1422029_at 1422422_at 1451823_at 1425675_s_at 1455956_x_at 1416122_at 1415741_at 1439475_at 1451611_at

BC002136 AW208668 J00406 BI663014 BC020489 AV325174 AW989410 NM_019440 AK004595 BB234229 AK002387 NM_011189 NM_019494 BC010489 NM_011909 NM_010398 BC006933 BB821035 BB132493 BG066664 AF128849 NM_009998 AF128849 BI076621 AK018713 AY034479 AW554392 AK003046 AY052560 BC001999 NM_013525 AV066321 BE824567 AF212320 BI076710 AW476171 BQ032232 BB269715 AW495711 BC019525 NM_019987 AF215982 NM_009773 BC024320 BG298986 AK007904 NM_138673 BC016252 AF114266 AV216331 BB234837 BC024320 AF099052 NM_010039 AY008277 M77196 AV310588 NM_009829 NM_011626 BB667905 BC024581

Coro1a Ids H2-D1 Cnn2 BC020489 Gtf2f1 Pbef1 Iigp2 Tyki BC013672 Pcgf5 Psme1 Cxcl11 38961 Usp18 H2-T23 Cdca7l Smn1 Rsad2 BC032204 Cyp2b10 Cyp2b10 Cyp2b10

coronin, actin binding protein 1A iduronate 2-sulfatase histocompatibility 2, D region locus 1 calponin 2 cDNA sequence BC020489 general transcription factor IIF, polypeptide 1 pre-B-cell colony-enhancing factor 1 interferon inducible GTPase 2 thymidylate kinase family LPS-inducible member cDNA sequence BC013672 polycomb group ring finger 5 proteasome (prosome, macropain) 28 subunit, alpha chemokine (C-X-C motif) ligand 11 septin 6 ubiquitin specific peptidase 18 histocompatibility 2, T region locus 23 cell division cycle associated 7 like survival motor neuron 1 radical S-adenosyl methionine domain containing 2 cDNA sequence BC032204 cytochrome P450, family 2, subfamily b, polypeptide 10 cytochrome P450, family 2, subfamily b, polypeptide 10 cytochrome P450, family 2, subfamily b, polypeptide 10

Cyba Eaf2 6230416A05Rik Nrn1 LOC671237 Emp3 Gas5 Spink4 6530403A03Rik Racgap1 9630010G10Rik Lrrc59 Nde1 Hif1a Trp53inp1 Noxo1 Ick Ccr10 Bub1b Ceacam2 Per2 Ccnd2 Stab2 Txndc5 Tgm2 Slc37a2 Arhgap15 Ceacam2 Ccl20 Defcr4 Clca4 Ceacam1 Ccnd2 Ccnd2 Tmem165 AI929863 Hrasls3

cytochrome b-245, alpha polypeptide ELL associated factor 2 RIKEN cDNA 6230416A05 gene neuritin 1 epithelial membrane protein 3 growth arrest specific 5 serine peptidase inhibitor, Kazal type 4 RIKEN cDNA 6530403A03 gene Rac GTPase-activating protein 1 RIKEN cDNA 9630010G10 gene leucine rich repeat containing 59 nuclear distribution gene E homolog 1 (A nidulans) hypoxia inducible factor 1, alpha subunit transformation related protein 53 inducible nuclear protein 1 NADPH oxidase organizer 1 intestinal cell kinase chemokine (C-C motif) receptor 10 budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) CEA-related cell adhesion molecule 2 period homolog 2 (Drosophila) cyclin D2 stabilin 2 thioredoxin domain containing 5 transglutaminase 2, C polypeptide solute carrier family 37 (glycerol-3-phosphate transporter), member 2 Rho GTPase activating protein 15 CEA-related cell adhesion molecule 2 chemokine (C-C motif) ligand 20 defensin related cryptdin 4 chloride channel calcium activated 4 CEA-related cell adhesion molecule 1 cyclin D2 cyclin D2 transmembrane protein 165 expressed sequence AI929863 HRAS like suppressor 3

-2,32 -2,29 -2,17 -2,36 -2,21 -2,14 -2,27 -2,05 -2,25 -2,11 -2,23 -2,18 -2,08 -2,18 -2,11 -2,09 -2,03 -2,09 -2,02 -2,04 -7,06 -6,39 -5,90 -3,21 -3,60 -2,46 -2,75 -2,91 -2,83 -2,70 -2,67 -2,88 -2,35 -2,50 -2,72 -2,64 -2,50 -2,43 -2,56 -2,40 -2,28 -2,80 -2,39 -2,42 -2,50 -2,76 -2,19 -2,76 -2,26 -2,17 -2,48 -2,54 -2,22 -2,46 -2,57 -2,29 -2,38 -2,60 -2,12 -2,22 -2,13

-0,10 0,03 0,52 -1,18 0,11 0,94 0,53 0,70 -0,02 0,37 1,62 1,23 0,17 -0,03 0,11 0,07 -0,03 0,65 0,05 -0,41 -0,11 -0,87 -0,55 0,24 -0,17 -0,29 -0,10 0,11 0,34 -0,17 0,27 0,43 0,14 1,74 -0,44 1,01 0,14 0,12 -0,24 0,58 0,26 0,25 0,87 0,39 0,50 1,02 -0,11 0,34 0,17 -0,14 -0,31 0,34 0,62 -0,32 0,52 0,56 -0,02 1,00 -0,36 0,53 0,78

1,28 0,78 6,80 1,80 0,36 0,90 1,15 1,57 2,07 1,78 1,54 1,89 2,27 1,26 0,68 0,02 -0,35 1,31 1,27 1,47 2,37 1,57 1,43 2,00 0,68 0,69 0,30 3,35 0,79 1,03 -0,50 -0,89 0,03 1,25 3,41 0,89 1,01 2,82 -0,37 0,77 1,79 2,41 1,52 -2,04 1,38 0,98 2,19 1,26 0,59 0,11 0,73 -1,73 2,29 1,55 0,68 -1,11 0,10 0,21 -0,24 -2,36 -0,58

7 X 17 10 15 17 12 11 12 8 19 14 5 X 6 17 12 13 12 19 7 7 7 ? 8 16 13 13 Un 7 1 4 13 15 17 11 16 12 4 17 9 11 2 7 1 6 10 13 2 9 2 7 1 8 3 7 6 6 5 13 19

126 490 922 66 603 736 79 391 762 56 688 526 33 405 721 58 015 831 27 055 649 36 444 210 54 532 564 93 434 746 33 343 689 121 211 575 35 638 031 118 285 869 101 225 150 27 029 020 7 066 021 25 606 435 25 606 435 25 606 435 125 310 865 36 712 124 36 733 092 45 786 105 41 108 726 38 212 404 99 448 532 94 445 913 14 083 052 74 826 867 11 083 587 24 425 837 77 899 092 100 989 071 118 289 696 25 224 802 93 246 389 127 091 327 86 271 008 38 507 740 157 807 847 36 978 819 43 570 835 25 224 802 82 995 805 22 657 071 144 760 127 25 170 462 127 091 327 127 091 327 77 258 654 7 624 502

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

1450099_a_at 1418230_a_at 1450217_at 1452661_at 1416234_at 1438211_s_at 1448229_s_at 1432466_a_at 1449591_at 1428480_at 1420479_a_at 1423986_a_at 1444283_at 1455316_x_at 1435431_at 1421920_a_at 1416958_at 1455577_at 1428850_x_at 1426657_s_at 1460259_s_at 1416384_a_at 1439539_at 1434248_at 1437044_a_at 1437025_at 1456377_x_at 1455454_at 1425469_a_at 1417651_at 1452565_x_at 1428947_at

NM_008094 BC005621 BG867337 AK011596 AW476171 BB550183 NM_009829 AK019319 NM_007609 AV307110 BG064031 BC010238 BB223831 AI987693 AW558989 NM_009913 NM_011584 BE196980 AK004342 L21027 AF108501 NM_021538 BB091955 BM243756 BB241507 AV313615 AV010467 BG073853 BC003855 NM_007815 M11024 AK008016

Gba Lims1 Ccl28 Tfrc Lrrc59 Dbp Ccnd2 Apoe Casp4 Cdca8 Nap1l1 Scotin Gimap7 Kcnh6 2310047M15Rik Ccr9 Nr1d2 Ccl28 Cd99 Phgdh Clca2 Cope Tram2 Prkch Gba Cd28 LOC632329 Akr1c19 9030208C03Rik Cyp2c29 LOC641050 2010001M09Rik

glucosidase, beta, acid LIM and senescent cell antigen-like domains 1 chemokine (C-C motif) ligand 28 transferrin receptor leucine rich repeat containing 59 D site albumin promoter binding protein cyclin D2 apolipoprotein E caspase 4, apoptosis-related cysteine peptidase cell division cycle associated 8 nucleosome assembly protein 1-like 1 scotin gene GTPase, IMAP family member 7 potassium voltage-gated channel, subfamily H (eag-related), member 6 RIKEN cDNA 2310047M15 gene chemokine (C-C motif) receptor 9 nuclear receptor subfamily 1, group D, member 2 chemokine (C-C motif) ligand 28 CD99 antigen 3-phosphoglycerate dehydrogenase chloride channel calcium activated 2 coatomer protein complex, subunit epsilon translocating chain-associating membrane protein 2 protein kinase C, eta glucosidase, beta, acid CD28 antigen

3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

1448511_at 1444177_at 1427301_at 1424927_at 1427891_at 1417426_at 1417597_at 1420782_at 1424065_at 1416957_at 1426174_s_at 1429682_at 1425927_a_at 1456064_at 1420928_at 1434068_s_at 1421653_a_at 1423182_at 1416926_at 1452535_at 1448617_at 1448021_at 1417500_a_at 1429381_x_at 1440196_at 1416416_x_at 1425584_x_at 1418296_at

NM_016933 AI451538 BE634960 BC025083 BB667753 NM_011157 NM_007642 NM_011608 BG064496 NM_011136 S69212 AK015259 AF375476 AI323624 BG075800 BE688410 NM_134051 AK004668 AW495711 Z95476 NM_007651 AA266723 BC016492 AK007826 BB207611 NM_010358 BC010605 NM_008761

Ptprcap LOC626058 Cd48 Glipr1 Gimap6 Prg1 Cd28 Tnfrsf17 Edem1 Pou2af1 Ighg 4930431B09Rik Atf5 AI504432 St6gal1 AI662270 Igh-VJ558 Tnfrsf13b Trp53inp1 Igh-1a Cd53 4930431B09Rik Tgm2 LOC238447 Arhgap18 Gstm1

protein tyrosine phosphatase, receptor type, C polypeptide-associated protein

Fxyd5

FXYD domain-containing ion transport regulator 5

aldo-keto reductase family 1, member C19 RIKEN cDNA 9030208C03 gene cytochrome P450, family 2, subfamily c, polypeptide 29 RIKEN cDNA 2010001M09 gene

CD48 antigen GLI pathogenesis-related 1 (glioma) GTPase, IMAP family member 6 proteoglycan 1, secretory granule CD28 antigen tumor necrosis factor receptor superfamily, member 17 ER degradation enhancer, mannosidase alpha-like 1 POU domain, class 2, associating factor 1 Immunoglobulin heavy chain (gamma polypeptide) RIKEN cDNA 4930431B09 gene activating transcription factor 5 expressed sequence AI504432 beta galactoside alpha 2,6 sialyltransferase 1 expressed sequence AI662270 immunoglobulin heavy chain (J558 family) tumor necrosis factor receptor superfamily, member 13b transformation related protein 53 inducible nuclear protein 1 immunoglobulin heavy chain 1a (serum IgG2a) CD53 antigen RIKEN cDNA 4930431B09 gene transglutaminase 2, C polypeptide Rho GTPase activating protein 18 glutathione S-transferase, mu 1

-2,19 -2,17 -2,57 -2,07 -2,24 -2,08 -2,39 -2,15 -2,25 -2,32 -2,12 -2,06 -2,19 -2,09 -2,17 -2,07 -2,31 -2,20 -2,16 -2,02 -2,07 -2,03 -2,12 -2,05 -2,05 -2,12 -2,22 -5,01 -4,89 -3,43 -3,65 -3,78

0,40 0,60 0,50 -0,04 0,23 -0,12 0,31 0,13 -0,33 0,25 -0,07 0,14 -0,06 -0,99 0,76 0,31 -0,71 0,36 -0,41 0,64 0,36 0,38 0,30 -0,16 -0,43 -0,18 -0,49 -0,65 1,98 -0,26 0,40 -0,23

0,09 1,64 5,51 0,41 0,47 2,08 -0,94 0,34 1,30 0,60 1,72 0,48 1,38 2,73 1,65 0,74 1,14 -0,76 -2,73 2,40 1,10 -0,48 -0,27 0,98 -0,09 0,99 1,04 1,08 6,27 -1,34 5,30 1,43

3 10 13 16 11 7 6 7 9 4 10 9 6 11 13 9 14 13 4 3 3 8 1 12 3 1 1 13 4 19 ? 18

-3,03 -3,25 -2,94 -3,81 -2,93 -2,93 -3,43 -2,97 -2,96 -3,62 -3,86 -3,30 -3,15 -2,76 -2,63 -2,93 -2,94 -2,56 -2,95 -2,62 -2,56 -3,80 -2,67 -2,87 -2,28 -2,46 -2,34 -2,53

0,06 -0,10 0,26 0,79 -0,75 0,06 -0,41 -0,35 0,78 0,22 1,47 0,61 -1,17 -0,82 -0,44 0,28 1,03 0,11 -0,99 0,64 0,53 0,79 0,65 1,16 -0,36 1,26 0,25 -1,46

1,48 5,04 1,17 2,02 1,35 1,38 1,73 0,61 -0,21 2,55 2,58 3,00 1,73 1,27 1,01 2,19 1,59 1,97 -0,90 0,21 1,92 2,14 1,21 1,48 1,30 1,98 3,49 1,55

19 1 1 10 6 10 1 16 6 9 12 3 7 3 16 11 ? 12 11 4 12 3 3 2 12 10 3 ? 7

89 288 866 57 718 903 1 330 631 32 528 767 94 445 913 45 573 273 127 091 327 18 854 794 5 308 873 124 420 768 110 884 726 108 896 032 48 648 206 105 824 292 123 527 136 16 997 183 1 330 631 98 398 575 144 734 469 73 231 773 20 986 529 74 503 878 89 288 866 60 691 013 4 232 985 39 340 413 35 773 245 4 154 645 173 518 729 111 389 566 48 631 168 61 889 784 60 691 013 11 227 386 108 794 428 50 965 919 113 755 089 100 600 588 44 680 299 107 167 559 23 140 095 113 706 525 60 957 029 11 083 587 113 876 327 106 887 989 100 597 118 157 807 847 113 706 562 26 461 927 108 140 313 30 741 497

3 3 4 4 4 4 4 4 4 4 4

_ _ _ _ _ _ _ _ _ _ _

1435560_at 1436996_x_at 1418072_at 1452540_a_at 1435926_at 1456174_x_at 1436317_at 1429694_at 1434277_a_at 1427929_a_at 1443620_at

BI554446 AV066625 NM_023422 M25487 BB529627 AV309418 BM115569 AK015050 BG069663 BG063905 BB212497

Itgal Lzp-s Hist1h2bc Hist1h2bp E030003F13Rik Ndrg1 D230012E17Rik 4930402H24Rik 6430570G24 Pdxk Gpc4

integrin alpha L P lysozyme structural histone 1, H2bc histone 1, H2bp RIKEN cDNA E030003F13 gene N-myc downstream regulated gene 1 RIKEN cDNA D230012E17 gene RIKEN cDNA 4930402H24 gene

4 4 4 4 4 4 4

_ _ _ _ _ _ _

1452207_at 1427797_s_at 1419506_at 1427798_x_at 1442750_at 1422948_s_at 1453840_at

Y15163 BF580235 NM_010282 BF580235 BG067768 NM_013550 AK005009

Cited2 Ctse Ggps1

pyridoxal (pyridoxine, vitamin B6) kinase glypican 4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 cathepsin E geranylgeranyl diphosphate synthase 1

B3galnt2 Hist1h3a Pabpc1

UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 histone 1, H3a poly A binding protein, cytoplasmic 1

-2,53 -2,60 3,06 1,52 -0,01 0,75 1,12 0,65 1,87 1,51 0,53

-0,75 0,55 -4,28 -2,82 -2,76 -2,59 -3,06 -2,84 -2,40 -2,39 -2,38

1,22 0,53 -2,60 -1,14 -0,82 0,40 -1,12 0,01 -2,32 -0,92 1,01

7 10 13 13 1 15 1 2 11 10 X

127 087 557 116 691 906 23 691 663 21 794 979

0,27 -1,71 -1,83 -0,41 -1,84 -0,95 -1,52

-2,28 -5,49 -3,99 -4,93 -3,24 -2,83 -3,18

0,69 6,93 -1,01 4,74 -0,48 -1,94 -0,85

10 1 13 ? 13 13 15

17 412 661 133 465 859 13 844 574

Genes were selected as described in Materials and Methods. Values are the mean of 3 S-scores comparing D2KO versus D2WT expression, B6KO versus B6WT expression, and D2WT versus B6WT expression.

66 758 990 130 399 302 86 752 622 77 842 100 48 297 548

13 746 799 23 769 317 36 540 251