Additional data file 2

Additional data file 2: List of the selected genes included in the human d-siRNA signaling library. UniqueID H01-0001 H01-0002 H01-0003 H01-0004 H01-0005 H01-0006 H01-0007 H01-0008 H01-0009 H01-0010 H01-0011 H01-0012 H01-0013 H01-0014 H01-0015 H01-0016 H01-0017 H01-0018 H01-0019 H01-0020 H01-0021 H01-0022 H01-0023 H01-0024 H01-0025 H01-0026 H01-0027 H01-0028 H01-0029 H01-0030 H01-0031 H01-0032 H01-0033 H01-0034 H01-0035 H01-0036 H01-0037 H01-0038 H01-0039 H01-0040 H01-0041 H01-0042 H01-0043 H01-0044 H01-0045 H01-0046 H01-0047

Gene BTK CDK4 CDKN1C CDKN2A CHS1 GSN GUCY2D JAK3 MTM1 MYL3 MYO5A MYO7A NF1 NPHP1 OCRL PHKG2 PTEN SPTB WAS CHM GPD2 GUCA1A MYL2 NCF2 PDE6A PLEC1 SOD1 STK11 TEK UBE3A RYR1 NOS3 NOS1 ANXA1 CACNB4 GUCY1A2 GUCY1A3 GUCY1B3 GUK1 NQO1 PDE3A PDE3B PDE4C PDE1B PLCB3 PLCB4 PPP3CA

NP# NP_000052 NP_000066 NP_000067 NP_000068 NP_000072 NP_000168 NP_000171 NP_000206 NP_000243 NP_000249 NP_000250 NP_000251 NP_000258 NP_000263 NP_000267 NP_000285 NP_000305 NP_000338 NP_000368 NP_000381 NP_000399 NP_000400 NP_000423 NP_000424 NP_000431 NP_000436 NP_000445 NP_000446 NP_000450 NP_000453 NP_000531 NP_000594 NP_000611 NP_000691 NP_000717 NP_000846 NP_000847 NP_000848 NP_000849 NP_000894 NP_000912 NP_000913 NP_000914 NP_000915 NP_000923 NP_000924 NP_000935

NM# NM_000061 NM_000075 NM_000076 NM_000077 NM_000081 NM_000177 NM_000180 NM_000215 NM_000252 NM_000258 NM_000259 NM_000260 NM_000267 NM_000272 NM_000276 NM_000294 NM_000314 NM_000347 NM_000377 NM_000390 NM_000408 NM_000409 NM_000432 NM_000433 NM_000440 NM_000445 NM_000454 NM_000455 NM_000459 NM_000462 NM_000540 NM_000603 NM_000620 NM_000700 NM_000726 NM_000855 NM_000856 NM_000857 NM_000858 NM_000903 NM_000921 NM_000922 NM_000923 NM_000924 NM_000932 NM_000933 NM_000944

Conserved Domains PH/BTK/SH3/SH2/TyrKc S_TKc CDI P19Arf_N perilipin/Beach/WD40 GEL ANF_receptor/pkinase/CYCc B41/SH2/TyrKc GRAM/PTPc_motif FRQ1 myosin_head MYSc/MyTH4//B41 RasGAP/SEC14 SH3 IPPc/RhoGAP S_TKc CDC14 SAC6/spectrin WH1/PBD GDI/GDI GlpA/FRQ1 FRQ1 FRQ1 TPR/SH3/PB1 GAF/PDEase SAC6/Smc/PLEC SPEC/SH3/FRQ1 S_TKc laminin_EGF/IG/FN3/TyrKc HECTc MIR/SPRY/RyR NO_synthase/CysJ PDZ/NO_synthase/CysJ annexin SH3/Ca_channel_B guanylate_cyc CYCc guanylate_cyc GuKc Flavodoxin_2 PDEase PDEase PDEase PDEase PI-PLC/PI-PLC/C2/SbcC PI-PLC/PLCc/C2/Smc PP2Ac

H01-0048 H01-0049 H01-0050 H01-0051 H01-0052 H01-0053 H01-0054 H01-0055 H01-0056 H01-0057 H01-0058 H01-0059 H01-0060 H01-0061 H01-0062 H01-0063 H01-0064 H01-0065 H01-0066 H01-0067 H01-0068 H01-0069 H01-0070 H01-0071 H01-0072 H01-0073 H01-0074 H01-0075 H01-0076 H01-0077 H01-0078 H01-0079 H01-0080 H01-0081 H01-0082 H01-0083 H01-0084 H01-0085 H01-0086 H01-0087 H01-0088 H01-0089 H01-0090 H01-0091 H01-0092 H01-0093 H01-0094 H01-0095 H01-0096 H01-0097 H01-0098

PPP3R1 RYR2 RYR3 ACTN1 ACTN2 ACTN3 ACVR1 ACVR2B ADCY7 ADCY8 ADCY9 AP1G1 ANK2 ANXA4 ANXA5 APBA1 ARHGAP5 ARHGDIB ARHGDIG ARL1 BMPR1B BUB1B CALU CAV2 CCNA2 CCNH CCNT1 CDK3 CDK6 CDK8 CDK9 CHEK1 CHUK AP2B1 CSNK1G2 DGKA DGKG DGKQ DAPK3 DLG2 DLG4 DOCK1 DOK1 DUSP9 DYRK1A ERN1 FLNA FLNB FYB GDI1 GDI2

NP_000936 NP_001026 NP_001027 NP_001093 NP_001094 NP_001095 NP_001096 NP_001097 NP_001105 NP_001106 NP_001107 NP_001119 NP_001139 NP_001144 NP_001145 NP_001154 NP_001164 NP_001166 NP_001167 NP_001168 NP_001194 NP_001202 NP_001210 NP_001224 NP_001228 NP_001230 NP_001231 NP_001249 NP_001250 NP_001251 NP_001252 NP_001265 NP_001269 NP_001273 NP_001310 NP_001336 NP_001337 NP_001338 NP_001339 NP_001355 NP_001356 NP_001371 NP_001372 NP_001386 NP_001387 NP_001424 NP_001447 NP_001448 NP_001456 NP_001484 NP_001485

NM_000945 NM_001035 NM_001036 NM_001102 NM_001103 NM_001104 NM_001105 NM_001106 NM_001114 NM_001115 NM_001116 NM_001128 NM_001148 NM_001153 NM_001154 NM_001163 NM_001173 NM_001175 NM_001176 NM_001177 NM_001203 NM_001211 NM_001219 NM_001233 NM_001237 NM_001239 NM_001240 NM_001258 NM_001259 NM_001260 NM_001261 NM_001274 NM_001278 NM_001282 NM_001319 NM_001345 NM_001346 NM_001347 NM_001348 NM_001364 NM_001365 NM_001380 NM_001381 NM_001395 NM_001396 NM_001433 NM_001456 NM_001457 NM_001465 NM_001493 NM_001494

FRQ1 MIR/SPRY/RyR MIR/SPRY/RyR SAC6 SAC6/spectrin SAC6 Activin_recp/GS/pkinase Activin_recp/pkinase guanylate_cyc guanylate_cyc guanylate_cyc Adaptin_N/Alpha_adaptinC2 Arp/ANK annexin annexin PID/PDZ RAB/FF/RhoGAP Rho_GDI Rho_GDI arf Activin_recp/pkinase S_TKc FRQ1 Caveolin cyclin CCL1 CCL1 S_TKc S_TKc S_TKc S_TKc S_TKc S_TKc Adaptin_N/Alpha_adaptinC2 pkinase FRQ1/DAG-bind/DAGKa FRQ1/DAG-bind/C1/DAGKa DAG-bind/C1/RA/DAGKa S_TKc PDZ/SH3/GuKc PDZ/SH3/GuKc SH3 IRS DSPc S_TKc S_TKc SAC6/Filamin/IG_FLMN SAC6/IG_FLMN/Filamin SH3 GDI GDI

H01-0099 H01-0100 H01-0101 H01-0102 H01-0103 H01-0104 H01-0105 H01-0106 H01-0107 H01-0108 H01-0109 H01-0110 H01-0111 H01-0112 H01-0113 H01-0114 H01-0115 H01-0116 H01-0117 H01-0118 H01-0119 H01-0120 H01-0121 H01-0122 H01-0123 H01-0124 H01-0125 H01-0126 H01-0127 H01-0128 H01-0129 H01-0130 H01-0131 H01-0132 H01-0133 H01-0134 H01-0135 H01-0136 H01-0137 H01-0138 H01-0139 H01-0140 H01-0141 H01-0142 H01-0143 H01-0144 H01-0145 H01-0146 H01-0147 H01-0148 H01-0149

GUCY2F INPPL1 IRAK1 IRAK2 ACVR2 ADRBK1 AIF1 AKT2 ANXA8 APXL ARAF1 ARCN1 ARF1 ARF3 ARF4 ARF4L ARF5 ARF6 RHOA ARHGAP4 ARL2 AXL BMX CALM2 CAMK4 CAPG CAPN2 CAV1 CCND1 CCND2 CCND3 CDK7 CENPE CHML CHN1 CSNK1A1 CTNNA1 MPP3 DRP2 DDR1 FES FLT1 FRK GAB1 GAP43 GNA11 GNA15 GNAI1 GNAI2 GNAL GNAQ

NP_001513 NP_001558 NP_001560 NP_001561 NP_001607 NP_001610 NP_001614 NP_001617 NP_001621 NP_001640 NP_001645 NP_001646 NP_001649 NP_001650 NP_001651 NP_001652 NP_001653 NP_001654 NP_001655 NP_001657 NP_001658 NP_001690 NP_001712.1 NP_001734 NP_001735 NP_001738 NP_001739 NP_001744 NP_001749 NP_001750 NP_001751 NP_001790 NP_001804 NP_001812 NP_001813 NP_001883 NP_001894 NP_001923 NP_001930 NP_001945 NP_001996 NP_002010 NP_002022 NP_002030 NP_002036 NP_002058 NP_002059 NP_002060 NP_002061 NP_002062 NP_002063

NM_001522 NM_001567 NM_001569 NM_001570 NM_001616 NM_001619 NM_001623 NM_001626 NM_001630 NM_001649 NM_001654 NM_001655 NM_001658 NM_001659 NM_001660 NM_001661 NM_001662 NM_001663 NM_001664 NM_001666 NM_001667 NM_001699 NM_001721 NM_001743 NM_001744 NM_001747 NM_001748 NM_001753 NM_053056 NM_001759 NM_001760 NM_001799 NM_001813 NM_001821 NM_001822 NM_001892 NM_001903 NM_001932 NM_001939 NM_001954 NM_002005 NM_002019 NM_002031 NM_002039 NM_002045 NM_002067 NM_002068 NM_002069 NM_002070 NM_002071 NM_002072

ANF_receptor/TyrKc/CYCc SH2/IPPc/SAM pkinase death/pkinase Activin_recp/pkinase RGS/S_TKc/PH FRQ1 PH/S_TKc annexin PDZ/DUF164 RBD/DAG_PE-bind/pkinase Adap_comp_sub ARF ARF ARF arf ARF ARF/SAR RHO FCH/RhoGAP/SH3 arf IG/FN3/TyrKc PH/BTK/SH2/TyrKc FRQ1 S_TKc GEL Calpain_III/FRQ1 Caveolin cyclin cyclin cyclin S_TKc KISc/Smc GDI/GDI SH2/DAG_PE-bind/RhoGAP pkinase Vinculin L27/PDZ/SH3/GuKc SPEC//WW/zz F5_F8_type_C/TyrKc FCH/SH2/TyrKc IG/TyrKc SH3/SH2/TyrKc PH IQ G-alpha G-alpha G-alpha G-alpha G-alpha G-alpha

H01-0150 H01-0151 H01-0152 H01-0153 H01-0154 H01-0155 H01-0156 H01-0157 H01-0158 H01-0159 H01-0160 H01-0161 H01-0162 H01-0163 H01-0164 H01-0165 H01-0166 H01-0167 H01-0168 H01-0169 H01-0170 H01-0171 H01-0172 H01-0173 H01-0174 H01-0175 H01-0176 H01-0177 H01-0178 H01-0179 H01-0180 H01-0181 H01-0182 H01-0183 H01-0184 H01-0185 H01-0186 H01-0187 H01-0188 H01-0189 H01-0190 H01-0191 H01-0192 H01-0193 H01-0194 H01-0195 H01-0196 H01-0197 H01-0198 H01-0199 H01-0200

GNAZ GNB1 GRK6 GRB2 GUCA1B HCK HPCA ITPKA ITPKB ITPR1 ITPR2 ITPR3 JAK1 KDR KIF3C KIFC1 KPNA2 LCP1 LTK LYN MARK3 MAP3K3 MAP3K11 MPP1 MSN MAP3K10 MX1 MX2 MYH9 MYH11 MLC1SA MYL5 PPP1R12A PPP1R12B NDUFS4 NEK2 NTRK3 OPHN1 OSBP PAK1 PAK3 PCTK2 PDE2A PDE4B PDE7A PDE9A PDPK1 PDZK1 PEX13 PFN2 PIK3C2A

NP_002064 NP_002065 NP_002073 NP_002077 NP_002089 NP_002101 NP_002134 NP_002211 NP_002212 NP_002213 NP_002214 NP_002215 NP_002218 NP_002244 NP_002245 NP_002254 NP_002257 NP_002289 NP_002335 NP_002341 NP_002367 NP_002392 NP_002410 NP_002427 NP_002435 NP_002437 NP_002453 NP_002454 NP_002464 NP_002465 NP_002466 NP_002468 NP_002471 NP_002472 NP_002486 NP_002488 NP_002521 NP_002538 NP_002547 NP_002567 NP_002569 NP_002586 NP_002590 NP_002591 NP_002594 NP_002597 NP_002604 NP_002605 NP_002609 NP_002619 NP_002636

NM_002073 NM_002074 NM_002082 NM_002086 NM_002098 NM_002110 NM_002143 NM_002220 NM_002221 NM_002222 NM_002223 NM_002224 NM_002227 NM_002253 NM_002254 NM_002263 NM_002266 NM_002298 NM_002344 NM_002350 NM_002376 NM_002401 NM_002419 NM_002436 NM_002444 NM_002446 NM_002462 NM_002463 NM_002473 NM_002474 NM_002475 NM_002477 NM_002480 NM_002481 NM_002495 NM_002497 NM_002530 NM_002547 NM_002556 NM_002576 NM_002578 NM_002595 NM_002599 NM_002600 NM_002603 NM_002606 NM_002613 NM_002614 NM_002618 NM_002628 NM_002645

G-alpha COG2319 RGS/S_TKc SH3/SH2 FRQ1 SH3/SH2/TyrKc FRQ1 IPK IPK MIR/PMT1/RYDR_ITPR MIR/MIR/RYDR_ITPR MIR/MIR/RYDR_ITPR B41/SH2/pkinase/TyrKc IG/IGc2/IG/IG/TyrKc/TyrKc kinesin KISc SRP1 SAC6/CH TyrKc SH3/SH2/TyrKc S_TKc/KA1 PB1/S_TKc SH3/TyrKc PDZ/SH3/GuKc Band_41/ERM SH3/TyrKc dynamin_2/GED dynamin_2 myosin_head/Myosin_tail myosin_head FRQ1 FRQ1 Arp Arp ETC_C1_NDUFA4 S_TKc LRRCT/IG/IGc2/TyrKc PH/RhoGAP PH/Oxysterol_BP PBD/S_TKc PBD/S_TKc S_TKc GAF/PDEase PDEase PDEase PDEase S_TKc PDZ Peroxin-13_N/SH3 profilin PI3K/PX/C2

H01-0201 H01-0202 H01-0203 H01-0204 H01-0205 H01-0206 H01-0207 H01-0208 H01-0209 H01-0210 H01-0211 H01-0212 H01-0213 H01-0214 H01-0215 H01-0216 H01-0217 H01-0218 H01-0219 H01-0220 H01-0221 H01-0222 H01-0223 H01-0224 H01-0225 H01-0226 H01-0227 H01-0228 H01-0229 H01-0230 H01-0231 H01-0232 H01-0233 H01-0234 H01-0235 H01-0236 H01-0237 H01-0238 H01-0239 H01-0240 H01-0241 H01-0242 H01-0243 H01-0244 H01-0245 H01-0246 H01-0247 H01-0248 H01-0249 H01-0250 H01-0251

PIK3C2B PIK3C3 PIM1 PIK3CG PIK4CB PLCG1 PLCG2 PLD1 PLD2 PLEK PLS1 PPP1CA PPP1CB PPP1CC PPP1R7 PPP1R10 PPP2CA PPP2R1B PPP2R2A PPP2R3A PPP2R5C PPP4C PPP6C PRKACA PRKACB PRKACG PRKAG1 PRKAR1A PRKAR2B PRKCA PRKCB1 PRKCG PRKCI PKN1 PRKD1 PRKCZ MAPK4 MAPK6 MAPK11 MAPK13 MAP2K1 EIF2AK2 PRKY PSD PTPN1 PTPN3 PTPN4 PTPN9 PTPN12 PTPRH PTPRJ

NP_002637 NP_002638 NP_002639 NP_002640 NP_002642 NP_002651 NP_002652 NP_002653 NP_002654 NP_002655 NP_002661 NP_002699 NP_002700 NP_002701 NP_002703 NP_002705 NP_002706 NP_002707 NP_002708 NP_002709 NP_002710 NP_002711 NP_002712 NP_002721 NP_002722 NP_002723 NP_002724 NP_002725 NP_002727 NP_002728 NP_002729 NP_002730 NP_002731 NP_002732 NP_002733 NP_002735 NP_002738 NP_002739 NP_002742 NP_002745 NP_002746 NP_002750 NP_002751 NP_002770 NP_002818 NP_002820 NP_002821 NP_002824 NP_002826 NP_002833 NP_002834

NM_002646 NM_002647 NM_002648 NM_002649 NM_002651 NM_002660 NM_002661 NM_002662 NM_002663 NM_002664 NM_002670 NM_002708 NM_002709 NM_002710 NM_002712 NM_002714 NM_002715 NM_002716 NM_002717 NM_002718 NM_002719 NM_002720 NM_002721 NM_002730 NM_002731 NM_002732 NM_002733 NM_002734 NM_002736 NM_002737 NM_002738 NM_002739 NM_002740 NM_002741 NM_002742 NM_002744 NM_002747 NM_002748 NM_002751 NM_002754 NM_002755 NM_002759 NM_002760 NM_002779 NM_002827 NM_002829 NM_002830 NM_002833 NM_002835 NM_002842 NM_002843

PI3K/PX/C2 PI3K pkinase PI3K PI3Kc PI-PLC/SH2/SH3/PH/C2/PLEC PLC/SH2/SH3/PH PX/PH/Cls PX/Cls PH/DEP/PH SAC6 PP2Ac PP2Ac PP2Ac COG4886 TFS2N/zf-CCCH PP2Ac HEAT CDC55 B56 PP2Ac PP2Ac S_TKc S_TKc S_TKc CBS RIIa/cNMP_binding RIIa/cNMP DAG-bind/C2/S_TKc DAG-bind/S_TKc DAG-bind/C2/S_TKc PB1/DAG_PE-bind/S_TKc HR1/S_TKc DAG-bind/PH/S_TKc PB1/DAG_PE-bind/S_TKc S_TKc S_TKc S_TKc S_TKc S_TKc DSRM/S_TKc S_TKc Sec7/PH PTPc Band_41/PDZ/PTPc Band_41/PDZ/PTPc CRAL_TRIO/PTPc PTPc FN3/PTPc FN3/PTPc

H01-0252 H01-0253 H01-0254 H01-0255 H01-0256 H01-0257 H01-0258 H01-0259 H01-0260 H01-0261 H01-0262 H01-0263 H01-0264 H01-0265 H01-0266 H01-0267 H01-0268 H01-0269 H01-0270 H01-0271 H01-0272 H01-0273 H01-0274 H01-0275 H01-0276 H01-0277 H01-0278 H01-0279 H01-0280 H01-0281 H01-0282 H01-0283 H01-0284 H01-0285 H01-0286 H01-0287 H01-0288 H01-0289 H01-0290 H01-0291 H01-0292 H01-0293 H01-0294 H01-0295 H01-0296 H01-0297 H01-0298 H01-0299 H01-0300 H01-0301 H01-0302

PTPRK PTPRM PTPRN PTPRZ1 RAB2 RAB3A RAB3B RAB5B RAB6A RAB13 RAC2 RAF1 RALB RANGAP1 RAP1A RAP1GA1 RCV1 RDX RGS1 RGS2 RGS10 RGS12 RGS16 GRK1 RIT2 ROS1 RPS6KA1 RYK MAPK12 MAP2K4 SH3BP2 ITSN1 SH3GL1 SH3GL2 SH3GL3 SHB SHC1 SNTA1 SPTA1 SPTAN1 SRI SRPK1 SRPK2 STAC STAT4 STAT5A STAT6 STIM1 NEK4 STK6 CDKL5

NP_002835 NP_002836 NP_002837 NP_002842 NP_002856 NP_002857 NP_002858 NP_002859 NP_002860 NP_002861 NP_002863 NP_002871 NP_002872 NP_002874 NP_002875 NP_002876 NP_002894 NP_002897 NP_002913 NP_002914 NP_002916 NP_002917 NP_002919 NP_002920 NP_002921 NP_002935 NP_002944 NP_002949 NP_002960 NP_003001 NP_003014 NP_003015 NP_003016 NP_003017 NP_003018 NP_003019 NP_003020 NP_003089 NP_003117 NP_003118 NP_003121 NP_003128 NP_003129 NP_003140 NP_003142 NP_003143 NP_003144 NP_003147 NP_003148 NP_003149 NP_003150

NM_002844 NM_002845 NM_002846 NM_002851 NM_002865 NM_002866 NM_002867 NM_002868 NM_002869 NM_002870 NM_002872 NM_002880 NM_002881 NM_002883 NM_002884 NM_002885 NM_002903 NM_002906 NM_002922 NM_002923 NM_002925 NM_002926 NM_002928 NM_002929 NM_002930 NM_002944 NM_002953 NM_002958 NM_002969 NM_003010 NM_003023 NM_003024 NM_003025 NM_003026 NM_003027 NM_003028 NM_003029 NM_003098 NM_003126 NM_003127 NM_003130 NM_003137 NM_003138 NM_003149 NM_003151 NM_003152 NM_003153 NM_003156 NM_003157 NM_003600 NM_003159

MAM/IG/FN3//PTPc MAM/IG/FN3//PTPc PTPc carb_anhydrase/fn3/PTPc RAB RAB RAB ras RAB RAB RHO RBD/DAG-bind/SPS1/pkinase RAS RNA1 RAS GoLoco/Rap_GAP FRQ1 Band_41/ERM RGS RGS RGS PDZ/PID/RGS/RBD RGS RGS/S_TKc RAS FN3/TyrKc S_TKc/S_TKc WIF/TyrKc S_TKc S_TKc PH/SH2 EH/Smc/SH3/RhoGEF/C2 BAR/SH3 BAR/SH3 BAR/SH3 SH2 PID/SH2 PDZ/PH spectrin spectrin FRQ1 S_TKc/S_TKc S_TKc/S_TKc DAG_PE-bind/SH3 STAT/STAT_bind/SH2 STAT/STAT_bind/SH2 STAT/STAT_bind/SH2 SAM/Smc S_TKc S_TKc S_TKc

H01-0303 H01-0304 H01-0305 H01-0306 H01-0307 H01-0308 H01-0309 H01-0310 H01-0311 H01-0312 H01-0313 H01-0314 H01-0315 H01-0316 H01-0317 H01-0318 H01-0319 H01-0320 H01-0321 H01-0322 H01-0323 H01-0324 H01-0325 H01-0326 H01-0327 H01-0328 H01-0329 H01-0330 H01-0331 H01-0332 H01-0333 H01-0334 H01-0335 H01-0336 H01-0337 H01-0338 H01-0339 H01-0340 H01-0341 H01-0342 H01-0343 H01-0344 H01-0345 H01-0346 H01-0347 H01-0348 H01-0349 H01-0350 H01-0351 H01-0352 H01-0353

AURKC RPS6KB1 STX5A STXBP1 SYK SYN2 SYT5 TEC ARFRP1 TGFBR2 TIAM1 TNNC2 TNNC1 PHLDA2 TTK TXK TYK2 UBE1L UBE2A UBE2B UBE2D1 UBE2D2 UBE2E1 UBE2G1 UBE2G2 UBE2H UBE2L3 UBE2N UBE2V2 USP4 VASP VAV2 VIL2 VRK1 VSNL1 WASPIP WEE1 YWHAH PTP4A1 USP7 STAM RASSF7 USP5 DYSF AXIN1 CDC7 PIP5K1A PIP5K1B PIP5K2B PLA2G6 ULK1

NP_003151 NP_003152 NP_003155 NP_003156 NP_003168 NP_003169 NP_003171 NP_003206 NP_003215 NP_003233 NP_003244 NP_003270 NP_003271 NP_003302 NP_003309 NP_003319 NP_003322 NP_003326 NP_003327 NP_003328 NP_003329 NP_003330 NP_003332 NP_003333 NP_003334 NP_003335 NP_003338 NP_003339 NP_003341 NP_003354 NP_003361 NP_003362 NP_003370 NP_003375 NP_003376 NP_003378 NP_003381 NP_003396 NP_003454 NP_003461 NP_003464 NP_003466 NP_003472 NP_003485 NP_003493 NP_003494 NP_003548 NP_003549 NP_003550 NP_003551 NP_003556

NM_003160 NM_003161 NM_003164 NM_003165 NM_003177 NM_003178 NM_003180 NM_003215 NM_003224 NM_003242 NM_003253 NM_003279 NM_003280 NM_003311 NM_003318 NM_003328 NM_003331 NM_003335 NM_003336 NM_003337 NM_003338 NM_003339 NM_003341 NM_003342 NM_003343 NM_003344 NM_003347 NM_003348 NM_003350 NM_003363 NM_003370 NM_003371 NM_003379 NM_003384 NM_003385 NM_003387 NM_003390 NM_003405 NM_003463 NM_003470 NM_003473 NM_003475 NM_003481 NM_003494 NM_003502 NM_003503 NM_003557 NM_003558 NM_003559 NM_003560 NM_003565

S_TKc S_TKc t_SNARE Sec1 SH2/TyrKc Synapsin C2 PH/BTK/SH3/SH2/TyrKc arf pkinase PH/RBD/PDZ/RhoGEF FRQ1 FRQ1 PH S_TKc SH3/SH2/TyrKc B41/SH2/TyrKc/ ThiF/UBACT COG5078 COG5078 COG5078 COG5078 COG5078 COG5078 COG5078 UBCc UBCc COG5078 UQ_con DUSP/UBP12 WH1 CH/RhoGEF/PH/DAG-bind/SH3/SH2 Band_41/ERM pkinase FRQ1 pkinase 14-3-3 CDC14 COG5077 VHS/SH3 RA UBP14 C2/DysFN RGS/DIX S_TKc PIPKc PIP5K PIPKc Arp/Patatin S_TKc

H01-0354 H01-0355 H01-0356 H01-0357 H01-0358 H01-0359 H01-0360 H01-0361 H01-0362 H01-0363 H01-0364 H01-0365 H01-0366 H01-0367 H01-0368 H01-0369 H01-0370 H01-0371 H01-0372 H01-0372 H01-0374 H01-0375 H01-0376 H01-0377 H01-0378 H01-0379 H01-0380 H01-0381 H01-0382 H01-0383 H01-0384 H01-0385 H01-0386 H01-0387 H01-0388 H01-0389 H01-0390 H01-0391 H01-0392 H01-0393 H01-0394 H01-0395 H01-0396 H01-0397 H01-0398 H01-0399 H01-0400 H01-0401 H01-0402 H01-0403 H01-0404

EEA1 BCAR3 ANXA9 STK24 NCK2 DYRK3 DUSP11 DOC2B DOC2A IRS4 CDC42BPA RGS5 MAP4K3 PPM1D PPFIA2 PIK3R3 DGKZ DGKE CAMK1 MKNK1 PDLIM4 CASK PRKRA STK16 RGS20 PLA2G4C VDP TP73L SCAP1 SOCS1 TNKS VAMP4 STX16 STX11 STX10 CTNNAL1 RNGTT RIPK1 RIPK2 NAPG NAPA MPDZ RGS9 DYRK4 INPP4B IQGAP1 SOCS2 CDK5R1 DDEF2 SYNJ1 SYNJ2

NP_003557 NP_003558 NP_003559 NP_003567 NP_003572 NP_003573 NP_003575 NP_003576 NP_003577 NP_003595 NP_003598 NP_003608 NP_003609 NP_003611 NP_003616 NP_003620 NP_003637 NP_003638 NP_003647 NP_003675.2 NP_003678 NP_003679 NP_003681 NP_003682 NP_003693 NP_003697 NP_003706 NP_003713 NP_003717 NP_003736 NP_003738 NP_003753 NP_003754 NP_003755 NP_003756 NP_003789 NP_003791 NP_003795 NP_003812 NP_003817 NP_003818 NP_003820 NP_003826 NP_003836 NP_003857 NP_003861 NP_003868 NP_003876 NP_003878 NP_003886 NP_003889

NM_003566 NM_003567 NM_003568 NM_003576 NM_003581 NM_003582 NM_003584 NM_003585 NM_003586 NM_003604 NM_003607 NM_003617 NM_003618 NM_003620 NM_003625 NM_003629 NM_003646 NM_003647 NM_003656 NM_003684 NM_003687 NM_003688 NM_003690 NM_003691 NM_003702 NM_003706 NM_003715 NM_003722 NM_003726 NM_003745 NM_003747 NM_003762 NM_003763 NM_003764 NM_003765 NM_003798 NM_003800 NM_003804 NM_003821 NM_003826 NM_003827 NM_003829 NM_003835 NM_003845 NM_003866 NM_003870 NM_003877 NM_003885 NM_003887 NM_003895 NM_003898

Smc/FYVE SH2/RasGEF annexin S_TKc SH3/SH2 S_TKc DSPc C2 C2 PH/IRS S_TKc/SbcC/DAG-bind/PH/CNH/PBD RGS S_TKc/CNH PP2Cc Smc/SAM SH2/SH2 C1/DAGKa/Arp DAG-bind/DAGKa S_TKc S_TKc PDZ/LIM S_TKc/L27/PDZ/SH3/GuKc DSRM/dsrm pkinase RGS PLA2_B Smc P53/SAM PH/SH3 SH2/SOCS Arp/SAM/PARP synaptobrevin COG5325 SynN t_SNARE Vinculin DSPc TyrKc/death pkinase/CARD

PDZ GGL/RGS S_TKc IQG1/WW/RasGAP SH2/SOCS CDK5_activator PH/ArfGap/SH3 Syja_N/IPPc Syja_N

H01-0405 H01-0406 H01-0407 H01-0408 H01-0409 H01-0410 H01-0411 H01-0412 H01-0413 H01-0414 H01-0415 H01-0416 H01-0417 H01-0418 H01-0419 H01-0420 H01-0421 H01-0422 H01-0423 H01-0424 H01-0425 H01-0426 H01-0427 H01-0428 H01-0429 H01-0430 H01-0431 H01-0432 H01-0433 H01-0434 H01-0435 H01-0436 H01-0437 H01-0438 H01-0439 H01-0440 H01-0441 H01-0442 H01-0443 H01-0444 H01-0445 H01-0446 H01-0447 H01-0448 H01-0449 H01-0450 H01-0451 H01-0452 H01-0453 H01-0454 H01-0455

ARHGEF7 CPNE3 MTMR2 PRPF4B RAB7L1 WASF1 BAIAP3 CDK5R2 AP3D1 USP13 RPS6KA4 HAPIP RPS6KB2 MAP3K14 SOCS3 STK29 UBE1C DOK2 SH2D2A PSTPIP1 TNK1 DMD INPP4A ANXA6 ANXA7 ADCY3 ANXA2 RHOB CCNG1 CDKN1B CETN1 CHN2 AP2M1 CLK1 PLK3 DGKB DCTN1 DLG1 DUSP3 FLT3 GMFB GUCY1B2 MYO9B PPP2CB PRKAR2A RAB1A RAB5A RAB27B RRAD STX3A UCHL1

NP_003890 NP_003900 NP_003903 NP_003904 NP_003920 NP_003922 NP_003924 NP_003927 NP_003929 NP_003931 NP_003933 NP_003938 NP_003943 NP_003945 NP_003946 NP_003948 NP_003959 NP_003965 NP_003966 NP_003969 NP_003976 NP_004001 NP_004018 NP_004024 NP_004025 NP_004027 NP_004030 NP_004031 NP_004051 NP_004055.1 NP_004057.1 NP_004058 NP_004059 NP_004062 NP_004064 NP_004071 NP_004073 NP_004078 NP_004081.1 NP_004110 NP_004115 NP_004120 NP_004136 NP_004147 NP_004148 NP_004152 NP_004153 NP_004154 NP_004156 NP_004168 NP_004172

NM_003899 NM_003909 NM_016156 NM_003913 NM_003929 NM_003931 NM_003933 NM_003936 NM_003938 NM_003940 NM_003942 NM_003947 NM_003952 NM_003954 NM_003955 NM_003957 NM_003968 NM_003974 NM_003975 NM_003978 NM_003985 NM_004010 NM_004027 NM_004033 NM_004034 NM_004036 NM_004039 NM_004040 NM_004060 NM_004064 NM_004066 NM_004067 NM_004068 NM_004071 NM_004073 NM_004080 NM_004082 NM_004087 NM_004090 NM_004119 NM_004124 NM_004129 NM_004145 NM_004156 NM_004157 NM_004161 NM_004162 NM_004163 NM_004165 NM_004177 NM_004181

SH3/RhoGEF/PH/ C2/VWA GRAM/PTPc_motif S_TKc RAB WH2 C2 CDK5_activator Adaptin_N UBP14 S_TKc/S_TKc SEC14/SPEC/RhoGEF/PH S_TKc S_TKc SH2/SOCS S_TKc ThiF/UBACT PH/PTBI SH2 FCH/SH3 TyrKc CH/spectrin/SbcC//WW annexin guanylate_cyc annexin RHO cyclin/CYCLIN CDI FRQ1 SH2/DAG_PE-bind/RhoGAP Adap_comp_sub S_TKc S_TKc/POLO_box FRQ1/DAGbinding NIP100/CAP_GLY/Smc PDZ/SH3/GuKc DSPc ig/TyrKc cofilin_ADF CYCc RA/MYSc/C1/RhoGAP PP2Ac RIIa/cNMP_binding ras ras ras RAS Syntaxin Peptidase_C12

H01-0456 H01-0457 H01-0458 H01-0459 H01-0460 H01-0461 H01-0462 H01-0463 H01-0464 H01-0465 H01-0466 H01-0467 H01-0468 H01-0469 H01-0470 H01-0471 H01-0472 H01-0473 H01-0474 H01-0475 H01-0476 H01-0477 H01-0478 H01-0479 H01-0480 H01-0481 H01-0482 H01-0483 H01-0484 H01-0485 H01-0486 H01-0487 H01-0488 H01-0489 H01-0490 H01-0491 H01-0492 H01-0493 H01-0494 H01-0495 H01-0496 H01-0497 H01-0498 H01-0499 H01-0500 H01-0501 H01-0502 H01-0503 H01-0504 H01-0505 H01-0506

CDKL1 STK19 PKMYT1 AURKB RAB11B UBE2L6 STK17B PSCD3 SOCS6 TRIP12 TRIP10 RAB28 RAB9A HOMER1 AKAP6 CABP1 RAB3D PSCDBP RIN1 GNA14 ALK ANXA13 ARHGAP1 ARHGDIA RHOH ARL3 ARRB2 KIF1A BMPR1A BRAF BUB1 CETN2 CETN3 CSK CSNK1G3 CTNNA2 DBN1 DNM1 DUSP1 DUSP2 DUSP5 DUSP8 DVL1 DVL2 DVL3 PHC2 EPHA2 EPHA4 EPHA5 EPHB3 EPHB4

NP_004187 NP_004188 NP_004194 NP_004208 NP_004209 NP_004214 NP_004217 NP_004218 NP_004223 NP_004229 NP_004231 NP_004240 NP_004242 NP_004263 NP_004265 NP_004267 NP_004274 NP_004279 NP_004283 NP_004288 NP_004295 NP_004297 NP_004299 NP_004300 NP_004301 NP_004302 NP_004304 NP_004312 NP_004320 NP_004324 NP_004327 NP_004335 NP_004356 NP_004374 NP_004375 NP_004380 NP_004386 NP_004399 NP_004408 NP_004409 NP_004410 NP_004411 NP_004412 NP_004413 NP_004414 NP_004418 NP_004422 NP_004429 NP_004430 NP_004434 NP_004435

NM_004196 NM_004197 NM_004203 NM_004217 NM_004218 NM_004223 NM_004226 NM_004227 NM_004232 NM_004238 NM_004240 NM_004249 NM_004251 NM_004272 NM_004274 NM_004276 NM_004283 NM_004288 NM_004292 NM_004297 NM_004304 NM_004306 NM_004308 NM_004309 NM_004310 NM_004311 NM_004313 NM_004321 NM_004329 NM_004333 NM_004336 NM_004344 NM_004365 NM_004383 NM_004384 NM_004389 NM_004395 NM_004408 NM_004417 NM_004418 NM_004419 NM_004420 NM_004421 NM_004422 NM_004423 NM_004427 NM_004431 NM_004438 NM_004439 NM_004443 NM_004444

S_TKc S_TKc S_TKc RAB UQ_con S_TKc Sec7/PH SH2/SOCS SRP1/WWE/HECTc FCH/SH3 RAB ras WH1/Smc spectrin FRQ1 RAB PDZ SH2/VPS9/RA G-alpha MAM/TyrKc annexin SEC14/RhoGAP Rho_GDI RHO arf arrestin/arrestin_C kinesin/FHA/PH Activin_recp/pkinase RBD/DAG_PE-bind/pkinase S_TKc FRQ1 FRQ1 SH3/SH2/TyrKc pkinase Vinculin cofilin_ADF dynamin_2/PH/GED RHOD/DSPc/CDC14 Rhodanese/DSPc RHOD/DSPc RHOD/DSPc DIX/PDZ/DEP DIX/Dishevelled/PDZ/DEP DIX/Dishevelled/PDZ/DEP SAM EPH_lbd/FN3//TyrKc/SAM EPH_lbd/FN3//TyrKc/SAM EPH_lbd/FN3/TyrKc EPH_lbd/VSP/fn3/TyrKc/SAM EPH_lbd/VSP/FN3TyrKc/SAM

H01-0507 H01-0508 H01-0509 H01-0510 H01-0511 H01-0512 H01-0513 H01-0514 H01-0515 H01-0516 H01-0517 H01-0518 H01-0519 H01-0520 H01-0521 H01-0522 H01-0523 H01-0524 H01-0525 H01-0526 H01-0527 H01-0528 H01-0529 H01-0530 H01-0531 H01-0532 H01-0533 H01-0534 H01-0535 H01-0536 H01-0537 H01-0538 H01-0539 H01-0540 H01-0541 H01-0542 H01-0543 H01-0544 H01-0545 H01-0546 H01-0547 H01-0548 H01-0549 H01-0550 H01-0551 H01-0552 H01-0553 H01-0554 H01-0555 H01-0556 H01-0557

EPS8 FGD1 GRB14 GRLF1 HRB USP6 ILK KIF2 KIF5B KIF5C KIF11 NEB PIK3C2G PLCB2 PPP2R2B RAB4A MAP4K2 RAB27A RABGGTA RABGGTB RAB5C RPS6KA3 STX1A TGFBR1 MAPKAPK3 RAB7 AP3B2 USP9X AXIN2 RASAL1 RAB11A LIN7A MTMR6 MTMR4 LATS1 CCNE2 RABEP1 HGS DGKI MAP3K13 AP4M1 DCAMKL1 BAIAP1 DLGAP2 DLG5 RPS6KA5 STK17A RGL2 SNAP29 TAOK2 UBE4A

NP_004438 NP_004454 NP_004481 NP_004482 NP_004495 NP_004496 NP_004508 NP_004511 NP_004512 NP_004513 NP_004514 NP_004534 NP_004561 NP_004564 NP_004567 NP_004569 NP_004570 NP_004571 NP_004572 NP_004573 NP_004574 NP_004577 NP_004594 NP_004603 NP_004626 NP_004628 NP_004635 NP_004643 NP_004646 NP_004649 NP_004654 NP_004655 NP_004676 NP_004678 NP_004681 NP_004693 NP_004694 NP_004703 NP_004708 NP_004712 NP_004713 NP_004725 NP_004733 NP_004736 NP_004738 NP_004746 NP_004751 NP_004752 NP_004773 NP_004774 NP_004779

NM_004447 NM_004463 NM_004490 NM_004491 NM_004504 NM_004505 NM_004517 NM_004520 NM_004521 NM_004522 NM_004523 NM_004543 NM_004570 NM_004573 NM_004576 NM_004578 NM_004579 NM_004580 NM_004581 NM_004582 NM_004583 NM_004586 NM_004603 NM_004612 NM_004635 NM_004637 NM_004644 NM_004652 NM_004655 NM_004658 NM_004663 NM_004664 NM_004685 NM_004687 NM_004690 NM_004702 NM_004703 NM_004712 NM_004717 NM_004721 NM_004722 NM_004734 NM_004742 NM_004745 NM_004747 NM_004755 NM_004760 NM_004761 NM_004782 NM_004783 NM_004788

PTB/SH3 RhoGEF/FYVE/PH RA/PH/SH2 ras/FF/RhoGAP ArfGap Arp/pkinase KISc kinesin/Smc kinesin/Smc KISc Nebulin/SH3 PI3K PI-PLC-X/PI-PLC-Y/C2/Smc CDC55 RAB S_TKc/CNH ras BET4 CAL1 ras S_TKc/S_TKc Syntaxin Activin_recp/GS/pkinase S_TKc Adaptin_N COG5077 RGS/DAX C2/RasGAP/BTK RAB L27/PDZ PTPc_motif PTPc_motif/FYVE UBA/S_TKc cyclin Rabaptin/Rabaptin VHS/FYVE DAGKa/Arp pkinase Adap_comp_sub DCX/DCX/S_TKc GuKc/WW/PDZ GKAP SbcC/PDZ/GuKc S_TKc/S_TKc S_TKc RasGEF/RA t_SNARE S_TKc UFD2

H01-0558 H01-0559 H01-0560 H01-0561 H01-0562 H01-0563 H01-0564 H01-0565 H01-0566 H01-0567 H01-0568 H01-0569 H01-0570 H01-0571 H01-0572 H01-0573 H01-0574 H01-0575 H01-0576 H01-0577 H01-0578 H01-0579 H01-0580 H01-0581 H01-0582 H01-0583 H01-0584 H01-0585 H01-0586 H01-0587 H01-0588 H01-0589 H01-0590 H01-0591 H01-0592 H01-0593 H01-0594 H01-0595 H01-0596 H01-0597 H01-0598 H01-0599 H01-0600 H01-0601 H01-0602 H01-0603 H01-0604 H01-0605 H01-0606 H01-0607 H01-0608

RAB33A KIF3B OTOF GRAP2 PARG1 TJP2 EIF2AK3 HOMER3 HOMER2 ARHGEF6 RASAL2 ROCK2 STX8 AKAP5 CLTC GMFG SEC22L1 PITPNM1 CALB1 CDK5 DNM2 MARK2 FRAP1 GUCY2C JAK2 KIF5A KTN1 MYO1E MYO6 ROR1 PDE1A PDE1C PFN1 PIK3CD PIP5K2A PLK1 PLS3 PRF1 RAC3 RANBP2L1 RAPSN PLA2G4B OSR1 PPP4R1 ANXA3 USP10 USP8 ADRBK2 AKT1 PPP2CZ ARHE

NP_004785 NP_004789 NP_004793 NP_004801 NP_004806 NP_004808 NP_004827 NP_004829 NP_004830 NP_004831 NP_004832 NP_004841 NP_004844 NP_004848 NP_004850 NP_004868 NP_004883 NP_004901 NP_004920 NP_004926 NP_004936 NP_004945 NP_004949 NP_004954 NP_004963 NP_004975 NP_004977 NP_004989 NP_004990 NP_005003 NP_005010 NP_005011 NP_005013 NP_005017 NP_005019 NP_005021 NP_005023 NP_005032 NP_005043 NP_005045 NP_005046 NP_005081 NP_005100 NP_005125 NP_005130 NP_005144 NP_005145 NP_005151 NP_005154 NP_005158 NP_005159

NM_004794 NM_004798 NM_004802 NM_004810 NM_004815 NM_004817 NM_004836 NM_004838 NM_004839 NM_004840 NM_004841 NM_004850 NM_004853 NM_004857 NM_004859 NM_004877 NM_004892 NM_004910 NM_004929 NM_004935 NM_004945 NM_004954 NM_004958 NM_004963 NM_004972 NM_004984 NM_004986 NM_004998 NM_004999 NM_005012 NM_005019 NM_005020 NM_005022 NM_005026 NM_005028 NM_005030 NM_005032 NM_005041 NM_005052 NM_005054 NM_005055 NM_005090 NM_005109 NM_005134 NM_005139 NM_005153 NM_005154 NM_005160 NM_005163 NM_005167 NM_005168

RAB kinesin C2 SH3/SH2 C1/RhoGAP PDZ/GuKc COG1520/S_TKc WH1 WH1 CH/RhoGEF/PH C2/RasGAP S_TKc/Smc/C1 MtPK/t_SNARE Clathrin/CLH cofilin_ADF SNC1 IP_trans/DDHD/SMP2 FRQ1 pkinase/S_TKc/TyrKc dynamin/PH/GED S_TKc/KA1 TEL1/FRB/PI3_PI4_kinase/FATC ANF_receptor/TyrKc/CYCc B41/SH2/TyrKc kinesin/Smc MYSc/SH3 MYSc IG/Fz/KR/TyrKc PDEase PDEase PROF PI3K PIP5K S_TKc/POLO_box SAC6 MACPF/C2 RHO Ran_BP1/GRIP COG5540 C2/PLA2_B S_TKc HEAT annexin UBP5 Rhodanese/UBP5 RGS/S_TKc/PH PH/S_TKc PP2Cc RHO

H01-0609 H01-0610 H01-0611 H01-0612 H01-0613 H01-0614 H01-0615 H01-0616 H01-0617 H01-0618 H01-0619 H01-0620 H01-0621 H01-0622 H01-0623 H01-0624 H01-0625 H01-0626 H01-0627 H01-0628 H01-0629 H01-0630 H01-0631 H01-0632 H01-0633 H01-0634 H01-0635 H01-0636 H01-0637 H01-0638 H01-0639 H01-0640 H01-0641 H01-0642 H01-0643 H01-0644 H01-0645 H01-0646 H01-0647 H01-0648 H01-0649 H01-0650 H01-0651 H01-0652 H01-0653 H01-0654 H01-0655 H01-0656 H01-0657 H01-0658 H01-0659

CALM3 CALML3 CAPN1 CCNC CDKN3 MAP3K8 CRK CRKL EPHA1 FER FGR GAK GEM GNAT2 GRK4 GRK5 GRB7 GRB10 RAPGEF1 HCLS1 HIP1 HRAS KIF25 LCK MCF2 RAB8A MOS MPP2 MYO1A PLXNB3 PPP1R3C PRKAB2 PRKCE PTPN14 ROCK1 SRC TIE TP53BP2 TP73 VAV1 YES1 ARHGEF5 ARHN PAMCI PDLIM7 GUCA1C AKT3 ABI1 LNK THRAP5 SH2D3C

NP_005175 NP_005176 NP_005177 NP_005181 NP_005183 NP_005195 NP_005197 NP_005198 NP_005223 NP_005237 NP_005239 NP_005246 NP_005252 NP_005263 NP_005298 NP_005299 NP_005301 NP_005302 NP_005303 NP_005326 NP_005329 NP_005334 NP_005346 NP_005347 NP_005360 NP_005361 NP_005363 NP_005365 NP_005370 NP_005384 NP_005389 NP_005390 NP_005391 NP_005392 NP_005397 NP_005408 NP_005415 NP_005417 NP_005418 NP_005419 NP_005424 NP_005426 NP_005431 NP_005438 NP_005442 NP_005450 NP_005456 NP_005461 NP_005466 NP_005472 NP_005480

NM_005184 NM_005185 NM_005186 NM_005190 NM_005192 NM_005204 NM_005206 NM_005207 NM_005232 NM_005246 NM_005248 NM_005255 NM_005261 NM_005272 NM_005307 NM_005308 NM_005310 NM_005311 NM_005312 NM_005335 NM_005338 NM_005343 NM_005355 NM_005356 NM_005369 NM_005370 NM_005372 NM_005374 NM_005379 NM_005393 NM_005398 NM_005399 NM_005400 NM_005401 NM_005406 NM_005417 NM_005424 NM_005426 NM_005427 NM_005428 NM_005433 NM_005435 NM_005440 NM_005447 NM_005451 NM_005459 NM_005465 NM_005470 NM_005475 NM_005481 NM_005489

FRQ1 FRQ1 Calpain_III/FRQ1 CCL1 CDC14 S_TKc SH2/SH3 SH2/SH3 EPH_lbd/FN3/TyrKc/SAM FCH/SH2/TyrKc SH3/SH2/TyrKc S_TKc/Y_phosphatase/DnaJ RAS G-alpha RGS/S_TKc/GRK4 RGS/S_TKc/GRK5 RA/PH/SH2 RA/PH/SH2 RasGEFN/RasGEF HS1_rep/SH3 Smc/ILWEQ RAS KISc SH3/SH2/TyrKc SEC14/SPEC/RhoGEF/PH ras pkinase L27/PDZ/SH3/GuKc MYSc Sema/PSI/TIG/RasGAP CBM_21 C2/DAG_PE-bind/S_TKc B41/PTPc S_TKc/C1 SH3/SH2/TyrKc EGF_Lam/fn3/fn3/fn3/TyrKc SbcC/ank/SH3 P53/SAM CH/RhoGEF/PH/DAG-bind/SH3/SH2 SH3/SH2/TyrKc RhoGEF/SH3 RHO RA PDZ/LIM FRQ1 PH/S_TKc SH3 PH/SH2 WD40 SH2/RasGEF

H01-0660 H01-0661 H01-0662 H01-0663 H01-0664 H01-0665 H01-0666 H01-0667 H01-0668 H01-0669 H01-0670 H01-0671 H01-0672 H01-0673 H01-0674 H01-0675 H01-0676 H01-0677 H01-0678 H01-0679 H01-0680 H01-0681 H01-0682 H01-0683 H01-0684 H01-0685 H01-0686 H01-0687 H01-0688 H01-0689 H01-0690 H01-0691 H01-0692 H01-0693 H01-0694 H01-0695 H01-0696 H01-0697 H01-0698 H01-0699 H01-0700 H01-0701 H01-0702 H01-0703 H01-0704 H01-0705 H01-0706 H01-0707 H01-0708 H01-0709 H01-0710

SH2D3A AP1M2 APBA2 CFL1 INPP5A INPP5D ITK KIFC3 LCP2 MUSK PPP3CC PTK2 RGS4 RHEB SDCBP SGK SOS1 SYBL1 SYT1 EPM2A USH1C RGS19IP1 ARPC5 ARPC4 ARPC3 ARPC1B ACTR3 ACTR2 KIF20A HIPK3 ARL7 ARL4A RASGRP1 G3BP ABI2 FARP1 SCAM-1 ACK1 PRKD3 STX6 STAM2 AKAP8 NET1 RGS19 PAK4 MAK MAP3K5 MLLT4 PTK6 STK10 UCHL3

NP_005481 NP_005489 NP_005494 NP_005498 NP_005530 NP_005532 NP_005537 NP_005541 NP_005556 NP_005583 NP_005596 NP_005598 NP_005604 NP_005605 NP_005616 NP_005618 NP_005624 NP_005629 NP_005630 NP_005661 NP_005700 NP_005707 NP_005708 NP_005709 NP_005710 NP_005711 NP_005712 NP_005713 NP_005724 NP_005725 NP_005728 NP_005729 NP_005730 NP_005745 NP_005750 NP_005757 NP_005766 NP_005772 NP_005804 NP_005810 NP_005834 NP_005849 NP_005854 NP_005864 NP_005875 NP_005897 NP_005914 NP_005927 NP_005966 NP_005981 NP_005993

NM_005490 NM_005498 NM_005503 NM_005507 NM_005539 NM_005541 NM_005546 NM_005550 NM_005565 NM_005592 NM_005605 NM_005607 NM_005613 NM_005614 NM_005625 NM_005627 NM_005633 NM_005638 NM_005639 NM_005670 NM_005709 NM_005716 NM_005717 NM_005718 NM_005719 NM_005720 NM_005721 NM_005722 NM_005733 NM_005734 NM_005737 NM_005738 NM_005739 NM_005754 NM_005759 NM_005766 NM_005775 NM_005781 NM_005813 NM_005819 NM_005843 NM_005858 NM_005863 NM_005873 NM_005884 NM_005906 NM_005923 NM_005936 NM_005975 NM_005990 NM_006002

SH2 Adap_comp_sub PID/PDZ ADF IPPc SH2/IPPc PH/BTK/SH3/SH2/TyrKc kinesin SAM/SH2/SH2 IG/IG/IGc2/Fz/TyrKc PP2Ac B41/TyrKc/Focal_AT RGS RAS PDZ S_TKc H2A/RhoGEF/PH/RasGEF synaptobrevin C2/C2 CBM_20/DSPc PDZ PDZ

P21-Arc COG2319 ACTIN ACTIN KISc/kinesin S_TKc/S_TKc arf arf RasGEF/DAG_PE-bind NTF2/RRM SH3 Band_41/RhoGEF/PH Sorb/SH3 TyrKc/SH3/DedD DAG_PE-bind/PH/S_TKc t_SNARE VHS/SH3 RhoGEF RGS PBD/S_TKc S_TKc S_TKc RA/FHA/DIL/PDZ SH3/SH2/TyrKc S_TKc/SbcC Peptidase_C12

H01-0711 H01-0712 H01-0713 H01-0714 H01-0715 H01-0716 H01-0717 H01-0718 H01-0719 H01-0720 H01-0721 H01-0722 H01-0723 H01-0724 H01-0725 H01-0726 H01-0727 H01-0728 H01-0729 H01-0730 H01-0731 H01-0732 H01-0733 H01-0734 H01-0735 H01-0736 H01-0737 H01-0738 H01-0739 H01-0740 H01-0741 H01-0742 H01-0743 H01-0744 H01-0745 H01-0746 H01-0747 H01-0748 H01-0749 H01-0750 H01-0751 H01-0752 H01-0753 H01-0754 H01-0755 H01-0756 H01-0757 H01-0758 H01-0759 H01-0760 H01-0761

CPNE6 CDC42BPB UBE4B RRAGB HRBL DLC1 MYL9 RAPGEF3 VAV3 MAP3K7IP1 DYNC1LI2 LASP1 NCK1 NSF DDR2 PDE4A PDE4D PDE6C PHKG1 PIK3CA PIK3CB PITPNA PLCD1 PLCL1 PPEF2 PPEF1 PPP1R3D PPP2R5A PPP2R5B PPP2R5D PPP2R5E PPP5C PRKAA1 PRKAA2 PRKCD PRKCH PKN2 PRKCQ PRKG1 PRKG2 RALGDS RANBP2 RRAS STK3 STK4 TESK1 TLN1 TSG101 TYRO3 VRK2 MAP3K12

NP_006023 NP_006026 NP_006039 NP_006055 NP_006067 NP_006085 NP_006088 NP_006096.2 NP_006104.3 NP_006107 NP_006132 NP_006139 NP_006144 NP_006169 NP_006173 NP_006193 NP_006194 NP_006195 NP_006204 NP_006209 NP_006210 NP_006215 NP_006216 NP_006217 NP_006230 NP_006231 NP_006233 NP_006234 NP_006235 NP_006236 NP_006237 NP_006238 NP_006242 NP_006243 NP_006245 NP_006246 NP_006247 NP_006248 NP_006249 NP_006250 NP_006257 NP_006258 NP_006261 NP_006272 NP_006273 NP_006276 NP_006280 NP_006283 NP_006284 NP_006287 NP_006292

NM_006032 NM_006035 NM_006048 NM_006064 NM_006076 NM_006094 NM_006097 NM_006105 NM_006113 NM_006116 NM_006141 NM_006148 NM_006153 NM_006178 NM_006182 NM_006202 NM_006203 NM_006204 NM_006213 NM_006218 NM_006219 NM_006224 NM_006225 NM_006226 NM_006239 NM_006240 NM_006242 NM_006243 NM_006244 NM_006245 NM_006246 NM_006247 NM_006251 NM_006252 NM_006254 NM_006255 NM_006256 NM_006257 NM_006258 NM_006259 NM_006266 NM_006267 NM_006270 NM_006281 NM_006282 NM_006285 NM_006289 NM_006292 NM_006293 NM_006296 NM_006301

C2/VWA S_TKc/DAG_PE-bind/CNH/PBD UFD2 ras ArfGap SAM/RhoGAP/START FRQ1 DEP/cNMP_binding/RasGEF CH/RhoGEF/PH/DAG_PE-bind/SH2/SH3 PP2C RAD55 LIM/NEBU/SH3 SH3/SH2 cdc48_N/SpoVK F5_F8_type_C/TyrKc PDEase PDEase GAF/GAF/PDEase S_TKc PI3K PI3K IP_trans PH/PLC/C2 PLCXc/PLCYc/C2 PP2Ac/PP2Ac/FRQ1 PP2Ac/FRQ1 CBM_21 B56 B56 B56 B56 NrfG/PP2Ac S_TKc S_TKc DAG_PE-bind/DAG_PE-bind/S_TKc C2/DAG_PE-bind/S_TKc HR1/S_TKc DAG_PE-bind/S_TKc cNMP/S_TKc S_TKc RasGEFN/RasGEF/RA Nrf/Ran_BP1/zf-RanBP RAS S_TKc S_TKc pkinase Band_41/ILWEQ UBCc/Smc IG/fn3/fn3/TyrKc pkinase pkinase

H01-0762 H01-0763 H01-0764 H01-0765 H01-0766 H01-0767 H01-0768 H01-0769 H01-0770 H01-0771 H01-0772 H01-0773 H01-0774 H01-0775 H01-0776 H01-0777 H01-0778 H01-0779 H01-0780 H01-0781 H01-0782 H01-0783 H01-0784 H01-0785 H01-0786 H01-0787 H01-0788 H01-0789 H01-0790 H01-0791 H01-0792 H01-0793 H01-0794 H01-0795 H01-0796 H01-0797 H01-0798 H01-0799 H01-0800 H01-0801 H01-0802 H01-0803 H01-0804 H01-0805 H01-0806 H01-0807 H01-0808 H01-0809 H01-0810 H01-0811 H01-0812

USP15 CNKSR1 MERTK CAP2 VTI1B STK25 UNC13B CIB2 IPO8 IPO7 DCTN2 NEDD9 ARPC1A ARFGEF2 ARFGEF1 RABAC1 USP16 CDC42EP3 PDLIM5 STAMBP RRP22 RGS14 DYRK2 GNAI3 RASA2 USP3 YKT6 RRAGA GNA13 MAP4K5 AVIL AP4B1 KIF1C GRAP PLK2 IQGAP2 WASF3 FRS2 PDE10A RAI USP20 RPIP8 NTE ABLIM1 MAP3K4 PSKH1 SLA YWHAE CDC42EP2 WDR3 RALBP1

NP_006304 NP_006305 NP_006334 NP_006357 NP_006361 NP_006365 NP_006368.2 NP_006374 NP_006381 NP_006382 NP_006391 NP_006394 NP_006400 NP_006411 NP_006412 NP_006414 NP_006438 NP_006440 NP_006448 NP_006454 NP_006468 NP_006471 NP_006473 NP_006487 NP_006497 NP_006528 NP_006546 NP_006561 NP_006563 NP_006566 NP_006567 NP_006585 NP_006603 NP_006604 NP_006613 NP_006624 NP_006637 NP_006645 NP_006652 NP_006654 NP_006667 NP_006686 NP_006693 NP_006711 NP_006715 NP_006733 NP_006739 NP_006752 NP_006770 NP_006775 NP_006779

NM_006313 NM_006314 NM_006343 NM_006366 NM_006370 NM_006374 NM_006377 NM_006383 NM_006390 NM_006391 NM_006400 NM_006403 NM_006409 NM_006420 NM_006421 NM_006423 NM_006447 NM_006449 NM_006457 NM_006463 NM_006477 NM_006480 NM_006482 NM_006496 NM_006506 NM_006537 NM_006555 NM_006570 NM_006572 NM_006575 NM_006576 NM_006594 NM_006612 NM_006613 NM_006622 NM_006633 NM_006646 NM_006654 NM_006661 NM_006663 NM_006676 NM_006695 NM_006702 NM_006720 NM_006724 NM_006742 NM_006748 NM_006761 NM_006779 NM_006784 NM_006788

UBP12/UBP12 SAM/PH IG/IFN3/TyrKc CAP t_SNARE S_TKc C2/DAG_PE-bind/C2/C2 FRQ1 SXM1 SXM1 SH3 COG2319 COG5307 COG5307 PRA1 UBP12/UBP12 PBD PDZ/LIM Mov34 RAS RGS/RBD S_TKc G-alpha C2/RasGAP/BTK UBP14/UBP12 SNC1 COG1100 G-alpha S_TKc/CNH GEL/VHP Adaptin_N KISc/FHA SH3/SH2 S_TKc/POLO_box/POLO_box IQG1/IQ/RasGAP WH2 IRS FhlA/GAF/PDEase SH3 UBP12/UBP12/DUSP/DUSP RUN cNMP_binding/RssA VHP S_TKc S_TKc SH3/SH2 14-3-3 PBD WD40 RhoGAP

H01-0813 H01-0814 H01-0815 H01-0816 H01-0817 H01-0818 H01-0819 H01-0820 H01-0821 H01-0822 H01-0823 H01-0824 H01-0825 H01-0826 H01-0827 H01-0828 H01-0829 H01-0830 H01-0831 H01-0832 H01-0833 H01-0834 H01-0835 H01-0836 H01-0837 H01-0838 H01-0839 H01-0840 H01-0841 H01-0842 H01-0843 H01-0844 H01-0845 H01-0846 H01-0847 H01-0848 H01-0849 H01-0850 H01-0851 H01-0852 H01-0853 H01-0854 H01-0855 H01-0856 H01-0857 H01-0858 H01-0859 H01-0860 H01-0861 H01-0862 H01-0863

AP3M2 RAB40B YWHAQ PLEKHC1 RAB32 CCNI KIF2C RABL4 RAB35 RAB31 CENTA1 DSTN RIPK3 PIM2 CALM1 MYO9A RIT1 SPTBN2 SYN1 RPH3AL WASF2 WWP2 CEP1 UBE2C RAPGEF4 DUSP14 HRIHFB2122 PTPN21 KIF3A TBC1D8 TRAD CALB2 CLTCL1 TRIO VCP VIL1 PICALM TESK2 NUP50 MAP4K1 SEC23IP ANXA10 IRAK3 AKAP10 DUSP10 C12orf2 CHP DUSP12 STXBP3 STK38 PTK9L

NP_006794 NP_006813 NP_006817 NP_006823 NP_006825 NP_006826 NP_006836 NP_006851 NP_006852 NP_006859 NP_006860 NP_006861 NP_006862 NP_006866 NP_008819 NP_008832 NP_008843 NP_008877 NP_008881 NP_008918 NP_008921 NP_008945 NP_008949 NP_008950 NP_008954 NP_008957 NP_008963 NP_008970 NP_008985 NP_008994 NP_008995 NP_009019 NP_009029 NP_009049 NP_009057 NP_009058 NP_009097 NP_009101 NP_009103 NP_009112 NP_009121 NP_009124 NP_009130 NP_009133 NP_009138 NP_009142 NP_009167 NP_009171 NP_009200 NP_009202 NP_009215

NM_006803 NM_006822 NM_006826 NM_006832 NM_006834 NM_006835 NM_006845 NM_006860 NM_006861 NM_006868 NM_006869 NM_006870 NM_006871 NM_006875 NM_006888 NM_006901 NM_006912 NM_006946 NM_006950 NM_006987 NM_006990 NM_007014 NM_007018 NM_007019 NM_007023 NM_007026 NM_007032 NM_007039 NM_007054 NM_007063 NM_007064 NM_007088 NM_007098 NM_007118 NM_007126 NM_007127 NM_007166 NM_007170 NM_007172 NM_007181 NM_007190 NM_007193 NM_007199 NM_007202 NM_007207 NM_007211 NM_007236 NM_007240 NM_007269 NM_007271 NM_007284

Adap_comp_sub RAB/SOCS 14-3-3 B41/PH/B41 RAB cyclin kinesin ras RAB RAS/arf/ARF/RAB/ras/RHO/RAN ArfGap/PH cofilin_ADF pkinase S_TKc FRQ1 RA/MYSc/DAG_PE-bind/RhoGAP RAS SAC6/SPEC/PH Synapsin_C RPH3A_effector C2/PRP40/WW/HECTc Smc UBCc cNMP_binding/DEP//RasGEF DSPc PH/Smc B41/PTPc kinesin GRAM/COG5210 RhoGEF/PH/IG/FN3/S_TKc FRQ1 Clathrin/CLH SEC14/SPEC/SH3/RhoGEF/PH/IG/S_TKc cdc48_N/SpoVK GEL/VHP ENTH pkinase RanBD S_TKc/CNH SAM/DDHD annexin death/pkinase RGS/RGS/RGS RHOD/DSPc RA FRQ1 DSPc Sec1 S_TKc/S_TK_X ADF/ADF

H01-0864 H01-0865 H01-0866 H01-0867 H01-0868 H01-0869 H01-0870 H01-0871 H01-0872 H01-0873 H01-0874 H01-0875 H01-0876 H01-0877 H01-0878 H01-0879 H01-0880 H01-0881 H01-0882 H01-0883 H01-0884 H01-0885 H01-0886 H01-0887 H01-0888 H01-0889 H01-0890 H01-0891 H01-0892 H01-0893 H01-0894 H01-0895 H01-0896 H01-0897 H01-0898 H01-0899 H01-0900 H01-0901 H01-0902 H01-0903 H01-0904 H01-0905 H01-0906 H01-0907 H01-0908 H01-0909 H01-0910 H01-0911 H01-0912 H01-0913 H01-0914

ABL1 KIF22 RANBP3 ZFYVE9 AP4E1 GNA12 RASA3 DNM1L AP3M1 APPL BRDG1 CCRK CD2AP CDC42EP4 FKBP8 RABGAP1 GCA MRAS RHOQ RRAS2 PLD3 CENTB2 TLK1 RAPGEF5 CABIN1 G3BP2 AIP1 AP2A2 EPB41L3 SHANK2 KIF4A MYO10 MYO1F OSTF1 PEF1 PFTK1 PITPNB PLXNB2 PRKCABP PTPN22 RAB3GAP2 PITPNC1 RGS17 RPS6KC1 SEC22L2 STAT5B TBL2 TIAM2 PSD4 STK39 PR48

NP_009297 NP_015556 NP_015560 NP_015563 NP_031373 NP_031379 NP_031394 NP_036193 NP_036227 NP_036228 NP_036240 NP_036251 NP_036252 NP_036253 NP_036313 NP_036329 NP_036330 NP_036351 NP_036381 NP_036382 NP_036400 NP_036419 NP_036422 NP_036426 NP_036427 NP_036429 NP_036433 NP_036437 NP_036439 NP_036441 NP_036442 NP_036466 NP_036467 NP_036515 NP_036524 NP_036527 NP_036531 NP_036533 NP_036539 NP_036543 NP_036546 NP_036549 NP_036551 NP_036556 NP_036562 NP_036580 NP_036585 NP_036586 NP_036587 NP_037365 NP_037371

NM_007313 NM_007317 NM_007321 NM_007324 NM_007347 NM_007353 NM_007368 NM_012063 NM_012095 NM_012096 NM_012108 NM_012119 NM_012120 NM_012121 NM_012181 NM_012197 NM_012198 NM_012219 NM_012249 NM_012250 NM_012268 NM_012287 NM_012290 NM_012294 NM_012295 NM_012297 NM_012301 NM_012305 NM_012307 NM_012309 NM_012310 NM_012334 NM_012335 NM_012383 NM_012392 NM_012395 NM_012399 NM_012401 NM_012407 NM_012411 NM_012414 NM_012417 NM_012419 NM_012424 NM_012430 NM_012448 NM_012453 NM_012454 NM_012455 NM_013233 NM_013239

SH3/SH2/TyrKc KISc/ComEA FYVE Adaptin_N G-alpha C2/RasGAP/BTK dynamin_2 Adap_comp_sub COG2905/PH/PTB SH2 S_TKc SH3 FKBP/TPR PTB/TBC/Smc EF-hand/FRQ1 RAS RHO RAS Cls PH/ArfGap/Arp S_TKc RasGEFN/RasGEF NTF2/RRM PDZ/GuKc/WW Adaptin_N/Alpha_adaptinC B41/Band_41/B41/ERM PDZ/SAM KISc/Smc MYSc/PH/MyTH4/B41 MYSc/SH3 SH3 FRQ1 S_TKc IP_trans RasGAP PDZ PTPc IP_trans RGS PX/MIT/S_TKc/S_TKc synaptobrevin STAT/STAT_bind/SH2 COG2319/WD40 RBD/PDZ/RhoGEF Sec7/PH S_TKc

H01-0915 H01-0916 H01-0917 H01-0918 H01-0919 H01-0920 H01-0921 H01-0922 H01-0923 H01-0924 H01-0925 H01-0926 H01-0927 H01-0928 H01-0929 H01-0930 H01-0931 H01-0932 H01-0933 H01-0934 H01-0935 H01-0936 H01-0937 H01-0938 H01-0939 H01-0940 H01-0941 H01-0942 H01-0943 H01-0944 H01-0945 H01-0946 H01-0947 H01-0948 H01-0949 H01-0950 H01-0951 H01-0952 H01-0953 H01-0954 H01-0955 H01-0956 H01-0957 H01-0958 H01-0959 H01-0960 H01-0961 H01-0962 H01-0963 H01-0964 H01-0965

TBK1 MYLIP CTNNA3 RACGAP1 HUMMLC2B EEF2K BLNK TPTE EPN1 PKN3 GGA1 PSCD4 NRBP USP25 RABL2A NCF4 ARHGAP6 NOX1 VCL IKBKE REM1 SACM1L GIT1 DBNL HIPK2 DUOX2 STXBP6 ITPK1 RAGE SLC25A13 PLK4 FREQ CAPN6 PIK3R5 RASD2 RUSC1 PPP1R15A RAB26 PTPN18 STK23 LAT NEK6 HRI PIB5PA TJP3 ARHGEF16 SIT1 RND1 PDLIM3 RPS6KA6 SH3BP4

NP_037386 NP_037394 NP_037398 NP_037409 NP_037424 NP_037434 NP_037446 NP_037447 NP_037465 NP_037487 NP_037497 NP_037517 NP_037524 NP_037528 NP_038198 NP_038202 NP_038286 NP_039249 NP_054706 NP_054721 NP_054731 NP_054735 NP_054749 NP_054782 NP_054794 NP_054799 NP_054897 NP_055031 NP_055041 NP_055066 NP_055079 NP_055101 NP_055104 NP_055123 NP_055125 NP_055143 NP_055145 NP_055168 NP_055184 NP_055185 NP_055202 NP_055212 NP_055228 NP_055237 NP_055243 NP_055263 NP_055265.1 NP_055285 NP_055291 NP_055311 NP_055336

NM_013254 NM_013262 NM_013266 NM_013277 NM_013292 NM_013302 NM_013314 NM_013315 NM_013333 NM_013355 NM_013365 NM_013385 NM_013392 NM_013396 NM_013412 NM_013416 NM_013427 NM_013955 NM_014000 NM_014002 NM_014012 NM_014016 NM_014030 NM_014063 NM_022740 NM_014080 NM_014178 NM_014216 NM_014226 NM_014251 NM_014264 NM_014286 NM_014289 NM_014308 NM_014310 NM_014328 NM_014330 NM_014353 NM_014369 NM_014370 NM_014387 NM_014397 NM_014413 NM_014422 NM_014428 NM_014448 NM_014450 NM_014470 NM_014476 NM_014496 NM_014521

S_TKc Band_41/COG5236 Vinculin Smc/DAG_PE-bind/RhoGAP FRQ1 MHCK_EF2_kinase/COG0790 Occludin/SH2 CDC14 ENTH HR1/HR1/S_TKc VHS/GAT/Alpha_adaptinC2 Sec7/PH S_TKc COG5077/UCH-2 RAB PX/SH3 RhoGAP Ferric_reduct Vinculin S_TKc RAS Syja_N ArfGap/GIT ADF/SH3 S_TKc FRQ1/Ferric_reduct RimK S_TKc FRQ1/mito_carr S_TKc FRQ1/EFh CysPc/Calpain_III/C2 RAS RUN/SH3 RAB PTPc S_TKc/S_TKc S_TKc S_TKc/pkinase IPPc PDZ/GuKc RhoGEF RHO PDZ/LIM S_TKc/S_TKc SH3

H01-0966 H01-0967 H01-0968 H01-0969 H01-0970 H01-0971 H01-0972 H01-0973 H01-0974 H01-0975 H01-0976 H01-0977 H01-0978 H01-0979 H01-0980 H01-0981 H01-0982 H01-0983 H01-0984 H01-0985 H01-0986 H01-0987 H01-0988 H01-0989 H01-0990 H01-0991 H01-0992 H01-0993 H01-0994 H01-0995 H01-0996 H01-0997 H01-0998 H01-0999 H01-1000 H01-1001 H01-1002 H01-1003 H01-1004 H01-1005 H01-1006 H01-1007 H01-1008 H01-1009 H01-1010 H01-1011 H01-1012 H01-1013 H01-1014 H01-1015 H01-1016

BCAR1 ARFGAP3 LATS2 RHOD HUNK HERC3 ARHGEF10 SH3MD1 MICAL2 PPM1F RALGPS1 IQCB1 PDE4DIP ENTH RIMS2 ULK2 RAB11FIP3 DOCK4 CENTB1 SLK SNPH STARD8 ZFYVE16 RIMS3 CENTG1 GIT2 ARHGAP11A ARHGEF11 ARHGEF17 MELK KIAA0528 FARP2 KIAA0317 FCHSD2 TBC1D4 RHOBTB1 ARK5 SNAP91 KIAA0274 SRGAP3 KIAA0672 IQSEC1 KIF14 ARHGAP25 RHOBTB3 DLGAP4 RAB11FIP2 PPM1E FRMPD1 AAK1 CENTG2

NP_055382 NP_055385 NP_055387 NP_055393 NP_055401 NP_055421 NP_055444 NP_055446 NP_055447 NP_055449 NP_055451 NP_055457 NP_055459 NP_055481 NP_055492 NP_055498 NP_055515 NP_055520 NP_055531 NP_055535 NP_055538 NP_055540 NP_055548 NP_055562 NP_055585 NP_055591 NP_055598 NP_055599 NP_055601 NP_055606 NP_055617 NP_055623 NP_055636 NP_055639 NP_055647 NP_055651 NP_055655 NP_055656 NP_055660 NP_055665 NP_055674 NP_055684 NP_055690 NP_055697 NP_055714 NP_055717 NP_055719 NP_055721 NP_055722 NP_055726 NP_055729

NM_014567 NM_014570 NM_014572 NM_014578 NM_014586 NM_014606 NM_014629 NM_014631 NM_014632 NM_014634 NM_014636 NM_014642 NM_014644 NM_014666 NM_014677 NM_014683 NM_014700 NM_014705 NM_014716 NM_014720 NM_014723 NM_014725 NM_014733 NM_014747 NM_014770 NM_014776 NM_014783 NM_014784 NM_014786 NM_014791 NM_014802 NM_014808 NM_014821 NM_014824 NM_014832 NM_014836 NM_014840 NM_014841 NM_014845 NM_014850 NM_014859 NM_014869 NM_014875 NM_014882 NM_014899 NM_014902 NM_014904 NM_014906 NM_014907 NM_014911 NM_014914

SH3 ArfGap S_TKc RHO S_TKc HECTc RhoGEF SH3 UbiH/SAC6/LIM PP2Cc RasGEF/PH IQ Myosin_tail/ERM ENTH PDZ/C2 S_TKc FRQ1/Smc SH3 PH/ArfGap/Arp S_TKc COG3883 RhoGAP/START FYVE C2 ras/PH/PH/ArfGap ArfGap/GIT RhoGAP PDZ/RGS/RhoGEF RhoGEF S_TKc/KA1 C2 Band_41/ERM/RhoGEF/PH/PH Filamin/HECTc SH3 PTB/TBC RHO/BTB S_TKc ENTH Syja_N FCH/RhoGAP/SH3 BAR/RhoGAP Sec7/PH KISc/FHA/ERM PH/RhoGAP/COG4694 ras/BTB GKAP C2 PP2Cc PDZ/B41 S_TKc ras/PH/PH/ArfGap/ank

H01-1017 H01-1018 H01-1019 H01-1020 H01-1021 H01-1022 H01-1023 H01-1024 H01-1025 H01-1026 H01-1027 H01-1028 H01-1029 H01-1030 H01-1031 H01-1032 H01-1033 H01-1034 H01-1035 H01-1036 H01-1037 H01-1038 H01-1039 H01-1040 H01-1041 H01-1042 H01-1043 H01-1044 H01-1045 H01-1046 H01-1047 H01-1048 H01-1049 H01-1050 H01-1051 H01-1052 H01-1053 H01-1054 H01-1055 H01-1056 H01-1057 H01-1058 H01-1059 H01-1060 H01-1061 H01-1062 H01-1063 H01-1064 H01-1065 H01-1066 H01-1067

LMTK2 CNKSR2 PLEKHA6 INPP5F RPH3A RIPX KIFAP3 RIMS1 WDFY3 RAB21 STK38L PDZD2 NEDL1 ARHGAP26 KIF1B SARM1 MCF2L2 SMG1 MAST2 RGL1 PMPCA SYNE2 PLCL2 ARHGEF9 PLCB1 EHBP1 KIF13B NEDD4L SASH1 MBC2 DOCK9 PSD3 ARHGEF12 PPP1R13B ARHGEF18 SCRIB SORBS1 PTPN23 RAB11FIP5 SAMHD1 SEC31L2 SH2B SIPA1L1 PPP1R16B DNM3 RAPGEF2 SGEF RAP1B SH3YL1 SDCBP2 STK36

NP_055731 NP_055742 NP_055750 NP_055752 NP_055769 NP_055776 NP_055785 NP_055804 NP_055806 NP_055814 NP_055815 NP_835260 NP_055867 NP_055886 NP_055889 NP_055892 NP_055893 NP_055907 NP_055927 NP_055964 NP_055975 NP_055995 NP_055999 NP_056000 NP_056007 NP_056067 NP_056069 NP_056092 NP_056093 NP_056107 NP_056111 NP_056125 NP_056128 NP_056131 NP_056133 NP_056171 NP_056200 NP_056281 NP_056285 NP_056289 NP_056305 NP_056318 NP_056371 NP_056383 NP_056384 NP_056407 NP_056410 NP_056461 NP_056492 NP_056500 NP_056505

NM_014916 NM_014927 NM_014935 NM_014937 NM_014954 NM_014961 NM_014970 NM_014989 NM_014991 NM_014999 NM_015000 NM_178140 NM_015052 NM_015071 NM_015074 NM_015077 NM_015078 NM_015092 NM_015112 NM_015149 NM_015160 NM_015180 NM_015184 NM_015185 NM_015192 NM_015252 NM_015254 NM_015277 NM_015278 NM_015292 NM_015296 NM_015310 NM_015313 NM_015316 NM_015318 NM_015356 NM_015385 NM_015466 NM_015470 NM_015474 NM_015490 NM_015503 NM_015556 NM_015568 NM_015569 NM_014247 NM_015595 NM_015646 NM_015677 NM_015685 NM_015690

TyrKc SAM/PDZ/PH PH COG5329 RPH3A_effector/C2 RUN/Smc RPH3A_effector/PDZ/C2 Beach/COG2319/FYVE ras S_TKc PDZ C2/HECTc BAR/PH/RhoGAP/SH3 KISc/FHA/PH SAM/SAM/TIR SEC14/RhoGEF/PH FAT/PI3_PI4_kinase/FATC S_TKc/PDZ RasGEFN/RasGEF/RA PqqL SAC6/Smc/SbcC/SPEC PH/PLCXc/PLCYc/C2 SH3/RhoGEF PI-PLC-X/PI-PLC-Y/C2 SAC6 KISc/SbcC/CAP_GLY C2/WW/HUL4 SAM COG5038/C2 PH Sec7/PH PDZ/RhoGEF PRP38/SbcC/Arp/SH3 ROM1/Dbl/RhoGEF/PH COG4886/PDZ Sorb/SH3 BRO1/Smc/PTPc C2 SAM/COG1078 COG2319 PH/SH2 Rap_GAP/PDZ Arp dynamin/PH/GED cNMP/RasGEFN/PDZ/RA RhoGEF/SH3 RAS COG2930/SH3 PDZ S_TKc

H01-1068 H01-1069 H01-1070 H01-1071 H01-1072 H01-1073 H01-1074 H01-1075 H01-1076 H01-1077 H01-1078 H01-1079 H01-1080 H01-1081 H01-1082 H01-1083 H01-1084 H01-1085 H01-1086 H01-1087 H01-1088 H01-1089 H01-1090 H01-1091 H01-1092 H01-1093 H01-1094 H01-1095 H01-1096 H01-1097 H01-1098 H01-1099 H01-1100 H01-1101 H01-1102 H01-1103 H01-1104 H01-1105 H01-1106 H01-1107 H01-1108 H01-1109 H01-1110 H01-1111 H01-1112 H01-1113 H01-1114 H01-1115 H01-1116 H01-1117 H01-1118

RUTBC3 LMO7 VILL EDD TNNI3K UBE2D4 SH3GLB1 RASD1 MK-STYX SAR1B ASB1 RAB10 DNCLI1 SHANK1 ASB2 TAOK2 RAB4B CRNN PRKAG2 PACSIN3 SNX9 NLK MYO15A HPCAL4 PLEKHO1 RAB23 TAOK3 IHPK2 RAB14 SFMBT1 EVL IPO11 RAPGEFL1 RAPGEF6 PLCE1 NIN DUSP13 CABP5 RAB9B ANKFY1 AKAP7 TCRIM VRK3 PLEK2 COPB1 NCKIPSD PRKD2 PDZK11 RANGNRF CRKRS CDKL3

NP_056520 NP_056668 NP_056957 NP_056986 NP_057062 NP_057067 NP_057093 NP_057168 NP_057170 NP_057187 NP_057198 NP_057215 NP_057225 NP_057232 NP_057234 NP_057235 NP_057238 NP_057274.1 NP_057287 NP_057307 NP_057308 NP_057315 NP_057323 NP_057341 NP_057358 NP_057361 NP_057365 NP_057375 NP_057406 NP_057413 NP_057421 NP_057422 NP_057423 NP_057424 NP_057425 NP_057434 NP_057448 NP_057451 NP_057454 NP_057460 NP_057461 NP_057472 NP_057524 NP_057529 NP_057535 NP_057537 NP_057541 NP_057568 NP_057576 NP_057591 NP_057592

NM_015705 NM_015843 NM_015873 NM_015902 NM_015978 NM_015983 NM_016009 NM_016084 NM_016086 NM_016103 NM_016114 NM_016131 NM_016141 NM_016148 NM_016150 NM_016151 NM_016154 NM_016190 NM_016203 NM_016223 NM_016224 NM_016231 NM_016239 NM_016257 NM_016274 NM_016277 NM_016281 NM_016291 NM_016322 NM_016329 NM_016337 NM_016338 NM_016339 NM_016340 NM_016341 NM_016350 NM_016364 NM_016367 NM_016370 NM_016376 NM_016377 NM_016388 NM_016440 NM_016445 NM_016451 NM_016453 NM_016457 NM_016484 NM_016492 NM_016507 NM_016508

TBC/SH3/RUN PDZ GEL/VHP ZnF_UBR1/PolyA/HECTc Arp/TyrKc COG5078 BAR/SH3 RAS RHOD/DSPc SAR Arp/ANK/SOCS ras COG4178 Arp/SH3/PDZ/SAM Arp/ank/SOCS S_TKc RAB S_100 COG2524 FCH/SH3 SH3/PX S_TKc MYSc/MyTH4/SH3/B41 FRQ1 PH ras S_TKc IPK RAB MBT/SAM WH1 CSE1 RasGEF PDZ/RA/RasGEF RasGEF/PLC/C2/RA Smc DSPc FRQ1 ras BTB/Arp/ank/FYVE LigT pkinase PH/DEP/PH Adaptin_N SH3 DAG_PE-bind/S_TKc PDZ S_TKc S_TKc

H01-1119 H01-1120 H01-1121 H01-1122 H01-1123 H01-1124 H01-1125 H01-1126 H01-1127 H01-1128 H01-1129 H01-1130 H01-1131 H01-1132 H01-1133 H01-1134 H01-1135 H01-1136 H01-1137 H01-1138 H01-1139 H01-1140 H01-1141 H01-1142 H01-1143 H01-1144 H01-1145 H01-1146 H01-1147 H01-1148 H01-1149 H01-1150 H01-1151 H01-1152 H01-1153 H01-1154 H01-1155 H01-1156 H01-1157 H01-1158 H01-1159 H01-1160 H01-1161 H01-1162 H01-1163 H01-1164 H01-1165 H01-1166 H01-1167 H01-1168 H01-1169

ICK UBAP1 RAB8B SKIP MST4 RBJ ANKMY1 RASL12 USP21 GMIP RAB6B C5orf5 SPTBN5 LIMK2 LIMK1 MAPT SHC3 STX18 PARD6A PDE11A USP18 CALML5 PRKAG3 MYO3A BAIAP2 PSCD1 PSCD2 WDR1 MKNK2 BMP2K DIRAS2 NKIRAS2 PPP1R9A AHI1 GIPC2 OTUB1 C20orf42 MTMR8 FLJ20184 ARHGAP8 DDEFL1 SNRK STAP2 FLJ20241 PPP1R14D OSBPL7 FNBP1L PRG-3 PXK OSBPL10 UBE2R2

NP_057597 NP_057609 NP_057614 NP_057616 NP_057626 NP_057628 NP_057636 NP_057647 NP_057656 NP_057657 NP_057661 NP_057687 NP_057726 NP_057952 NP_058015 NP_058525 NP_058544 NP_058626 NP_058644 NP_058649 NP_059110 NP_059118 NP_059127 NP_059129 NP_059344 NP_059430 NP_059431 NP_059830 NP_060042 NP_060063 NP_060064 NP_060065 NP_060120 NP_060121 NP_060125 NP_060140 NP_060141 NP_060147 NP_060170 NP_060171 NP_060177 NP_060189 NP_060190 NP_060191 NP_060196 NP_060201 NP_060207 NP_060223 NP_060241 NP_060254 NP_060281

NM_016513 NM_016525 NM_016530 NM_016532 NM_016542 NM_016544 NM_016552 NM_016563 NM_016572 NM_016573 NM_016577 NM_016603 NM_016642 NM_016733 NM_016735 NM_016841 NM_016848 NM_016930 NM_016948 NM_016953 NM_017414 NM_017422 NM_017431 NM_017433 NM_017450 NM_017456 NM_017457 NM_017491 NM_017572 NM_017593 NM_017594 NM_017595 NM_017650 NM_017651 NM_017655 NM_017670 NM_017671 NM_017677 NM_017700 NM_017701 NM_017707 NM_017719 NM_017720 NM_017721 NM_017726 NM_017731 NM_017737 NM_017753 NM_017771 NM_017784 NM_017811

S_TKc ras IPPc S_TKc RAB/DnaJ ank/Arp RAS UBP5 FCH/C1/RhoGAP ras RhoGAP SAC6/SPEC/PH LIM//Dlg/PDZ/TyrKc LIM/PDZ tubulin-binding PID/SH2 PB1/PDZ GAF/PDEase COG5077 FRQ1 COG2524 S_TKc/MYSc SbcC/SH3 Sec7/PH Sec7/PH WD40 S_TKc S_TKc RAS ras SAM SH3 PDZ COG5539 B41/PH PTPc_motif RhoGEF PH/ArfGap/Arp S_TKc SH2 DM14/C2 PH/Oxysterol_BP SH3 PAP2 PX/S_TKc PH/Oxysterol_BP COG5078

H01-1170 H01-1171 H01-1172 H01-1173 H01-1174 H01-1175 H01-1176 H01-1177 H01-1178 H01-1179 H01-1180 H01-1181 H01-1182 H01-1183 H01-1184 H01-1185 H01-1186 H01-1187 H01-1188 H01-1189 H01-1190 H01-1191 H01-1192 H01-1193 H01-1194 H01-1195 H01-1196 H01-1197 H01-1198 H01-1199 H01-1200 H01-1201 H01-1202 H01-1203 H01-1204 H01-1205 H01-1206 H01-1207 H01-1208 H01-1209 H01-1210 H01-1211 H01-1212 H01-1213 H01-1214 H01-1215 H01-1216 H01-1217 H01-1218 H01-1219 H01-1220

RAB20 DUSP23 AYTL1 SSH3 FLJ20574 TESC STX17 FLJ20701 CADPS2 EPN3 PLEKHB2 RUFY2 SCYL2 FRMD4A RALGPS2 PLEKHJ1 ARHGAP17 FLJ10324 FLJ10357 ECT2 EFHC1 DOK4 DIP13B FLJ10665 ARL8B UBE1L2 C14orf108 MULK KIF24 ARHGAP12 RHOT1 UEV3 PI4K2B MCTP2 FGD6 LIN7C DEPDC1B SYNJ2BP PLCXD1 CENTA2 STYK1 PAG PPM2C TIP120A ARHGAP15 TOPK MARK1 ANLN ERBB2IP MYO5C LOC55971

NP_060287 NP_060293 NP_060309 NP_060327 NP_060356 NP_060369 NP_060389 NP_060403 NP_060424 NP_060427 NP_060428 NP_060457 NP_060458 NP_060497 NP_060507 NP_060519 NP_060524 NP_060529 NP_060541 NP_060568 NP_060570 NP_060580 NP_060641 NP_060643 NP_060654 NP_060697 NP_060699 NP_060708 NP_060748 NP_060757 NP_060777 NP_060784 NP_060793 NP_060819 NP_060821 NP_060832 NP_060839 NP_060843 NP_060860 NP_060874 NP_060893 NP_060910 NP_060914 NP_060918 NP_060930 NP_060962 NP_061120 NP_061155 NP_061165 NP_061198 NP_061330

NM_017817 NM_017823 NM_017839 NM_017857 NM_017886 NM_017899 NM_017919 NM_017933 NM_017954 NM_017957 NM_017958 NM_017987 NM_017988 NM_018027 NM_018037 NM_018049 NM_018054 NM_018059 NM_018071 NM_018098 NM_018100 NM_018110 NM_018171 NM_018173 NM_018184 NM_018227 NM_018229 NM_018238 NM_018278 NM_018287 NM_018307 NM_018314 NM_018323 NM_018349 NM_018351 NM_018362 NM_018369 NM_018373 NM_018390 NM_018404 NM_018423 NM_018440 NM_018444 NM_018448 NM_018460 NM_018492 NM_018650 NM_018685 NM_018695 NM_018728 NM_018842

ras CDC14 PlsC/FRQ1 DSPc S_TKc FRQ1 t_SNARE PTB PH ENTH PH RUN/FYVE S_TKc/TyrKc B41 RasGEF PH BAR/RhoGAP DIL/PDZ PH BRCT/BRCT/RhoGEF DM10/FRQ1 PH/PTBI PH/PTB RhoGEF arf ThiF/UBACT Adap_comp_sub LCB5 SH3/WW/PH/RhoGAP RHO/RAB UBCc/Mdh/ldh_C C2 RhoGEF/FYVE/PH L27/PDZ DEP/RhoGAP PDZ PI-PLC-X ArfGap/PH TyrKc PP2C Adaptin_N PH/RhoGAP pkinase S_TKc/TyrKc/UBA/KA1 PH PDZ MYSc/Smc/Myosin_tail/ERM/DIL SH3

H01-1221 H01-1222 H01-1223 H01-1224 H01-1225 H01-1226 H01-1227 H01-1228 H01-1229 H01-1230 H01-1231 H01-1232 H01-1233 H01-1234 H01-1235 H01-1236 H01-1237 H01-1238 H01-1239 H01-1240 H01-1241 H01-1242 H01-1243 H01-1244 H01-1245 H01-1246 H01-1247 H01-1248 H01-1249 H01-1250 H01-1251 H01-1252 H01-1253 H01-1254 H01-1255 H01-1256 H01-1257 H01-1258 H01-1259 H01-1260 H01-1261 H01-1262 H01-1263 H01-1264 H01-1265 H01-1266 H01-1267 H01-1268 H01-1269 H01-1270 H01-1271

PDE7B SH3BP1 UBASH3A SNTG1 SNTG2 PRKWNK1 SSH1 SH3TC1 CXorf9 RIN2 TOLLIP PLEKHA5 RHOF APBB1IP MTMR12 CCNJ ARFRP2 PLEKHA3 ARHGEF3 PARD3 PPP4R2 GSK3A INPP5E GRIPAP1 SH3GLB2 SAR1A PAK6 DUSP22 KNSL7 CABC1 ARRB1 CCNL1 ACVR1B NKIRAS1 C20orf32 RPGRIP1 HRASLS RAB25 LOC57117 GOPC ADCK1 PACE-1 CAMK1G EPHA8 ADCY2 AMHR2 RIPK4 RCN3 RHOJ CLK4 RAB22A

NP_061818 NP_061830 NP_061834 NP_061840 NP_061841 NP_061852 NP_061857 NP_061859 NP_061863 NP_061866 NP_061882 NP_061885 NP_061907 NP_061916 NP_061934 NP_061957 NP_061960 NP_061964 NP_062455 NP_062565 NP_062827 NP_063937 NP_063945 NP_064522 NP_064530 NP_064535 NP_064553 NP_064570 NP_064627 NP_064632 NP_064647 NP_064703 NP_064733 NP_065078 NP_065089 NP_065099 NP_065119 NP_065120 NP_065128 NP_065132 NP_065154 NP_065156 NP_065172 NP_065387 NP_065433 NP_065434 NP_065690 NP_065701 NP_065714 NP_065717 NP_065724

NM_018945 NM_018957 NM_018961 NM_018967 NM_018968 NM_018979 NM_018984 NM_018986 NM_018990 NM_018993 NM_019009 NM_019012 NM_019034 NM_019043 NM_019061 NM_019084 NM_019087 NM_019091 NM_019555 NM_019619 NM_019853 NM_019884 NM_019892 NM_020137 NM_020145 NM_020150 NM_020168 NM_020185 NM_020242 NM_020247 NM_020251 NM_020307 NM_020328 NM_020345 NM_020356 NM_020366 NM_020386 NM_020387 NM_020395 NM_020399 NM_020421 NM_020423 NM_020439 NM_020526 NM_020546 NM_020547 NM_020639 NM_020650 NM_020663 NM_020666 NM_020673

PDEase BAR/RhoGAP UBP14/SH3/GpmB PDZ/PH PDZ S_TKc DSPc SH3 SH3/SAM VPS9/RA C2/CUE PH/Smc RHO RA/PH cyclin_C arf PH RhoGEF PDZ/Prc S_TKc IPPc BAR SAR PBD/S_TKc DSPc KISc AarF arrestin CYCLIN/bZIP Activin_recp/pkinase ras SH3 Smc/C2 RAB PHD PDZ AarF pkinase S_TKc EPH_lbd/FN3/TyrKc/SAM guanylate_cyc Activin_recp/pkinase pkinase/Arp/ank FRQ1 RHO S_TKc ras

H01-1272 H01-1273 H01-1274 H01-1275 H01-1276 H01-1277 H01-1278 H01-1279 H01-1280 H01-1281 H01-1282 H01-1283 H01-1284 H01-1285 H01-1286 H01-1287 H01-1288 H01-1289 H01-1290 H01-1291 H01-1292 H01-1293 H01-1294 H01-1295 H01-1296 H01-1297 H01-1298 H01-1299 H01-1300 H01-1301 H01-1302 H01-1303 H01-1304 H01-1305 H01-1306 H01-1307 H01-1308 H01-1309 H01-1310 H01-1311 H01-1312 H01-1313 H01-1314 H01-1315 H01-1316 H01-1317 H01-1318 H01-1319 H01-1320 H01-1321 H01-1322

CASKIN2 CASKIN1 CGN SYT4 LRRC7 PACSIN1 ARHGAP21 SYT13 WDFY1 OSBPL8 PITPNM2 SHRM STIM2 USP28 OSBPL5 PLEKHA4 PRKWNK3 CPNE5 PRX MAGI-3 APS ADCY6 ANK3 GNAO1 PDLIM1 SNTB1 RAP2A TSC2 ARGBP2 DLG3 PPP3CB RPS6KA2 UNG2 COTL1 TRIB3 RAP1GDS1 RAB40C RAP2C PLEKHB1 SRPRB RHOU MYL7 RRAGD RAB18 AFAP TRIB2 SMAP1 ABR UBE2V1 DEF6 CSNK1G1

NP_065804 NP_065815 NP_065821 NP_065834 NP_065845 NP_065855 NP_065875 NP_065877 NP_065881 NP_065892 NP_065896 NP_065910 NP_065911 NP_065937 NP_065947 NP_065955 NP_065973 NP_065990 NP_066007 NP_066016 NP_066189 NP_066193 NP_066267 NP_066268 NP_066272 NP_066301 NP_066361 NP_066400 NP_066547 NP_066943 NP_066955 NP_066958 NP_066970 NP_066972 NP_066981 NP_066982 NP_066991 NP_067006 NP_067023 NP_067026 NP_067028 NP_067046 NP_067067 NP_067075 NP_067651 NP_067675 NP_068759 NP_068781 NP_068823 NP_071330 NP_071331

NM_020753 NM_020764 NM_020770 NM_020783 NM_020794 NM_020804 NM_020824 NM_020826 NM_020830 NM_020841 NM_020845 NM_020859 NM_020860 NM_020886 NM_020896 NM_020904 NM_020922 NM_020939 NM_020956 NM_020965 NM_020979 NM_020983 NM_020987 NM_020988 NM_020992 NM_021021 NM_021033 NM_021056 NM_021069 NM_021120 NM_021132 NM_021135 NM_021147 NM_021149 NM_021158 NM_021159 NM_021168 NM_021183 NM_021200 NM_021203 NM_021205 NM_021223 NM_021244 NM_021252 NM_021638 NM_021643 NM_021940 NM_021962 NM_021988 NM_022047 NM_022048

Arp/SAM Arp/SAM Myosin_tail C2 PDZ FCH/SH3 PDZ/PH/RhoGAP C2 COG2319 PH/Oxysterol_BP IP_trans/DDHD/SMP2 PDZ/SbcC SAM/Smc UCH-2 PH/Oxysterol_BP PH S_TKc C2/VWA PDZ GuKc/WW/PDZ PH/SH2 guanylate_cyc Arp/ank/ZU5/DEATH G-alpha PDZ/LIM PDZ/PH RAS Tuberin/Rap_GAP Sorb/SH3 PDZ/SH3/GuKc PP2Ac S_TKc cyclin ADF S_TKc SRP1 RAB RAS PH arf RHO FRQ1 COG1100 RAB PH S_TKc ArfGap RhoGEF/C2/RhoGAP UQ_con PH pkinase

H01-1323 H01-1324 H01-1325 H01-1326 H01-1327 H01-1328 H01-1329 H01-1330 H01-1331 H01-1332 H01-1333 H01-1334 H01-1335 H01-1336 H01-1337 H01-1338 H01-1339 H01-1340 H01-1341 H01-1342 H01-1343 H01-1344 H01-1345 H01-1346 H01-1347 H01-1348 H01-1349 H01-1350 H01-1351 H01-1352 H01-1353 H01-1354 H01-1355 H01-1356 H01-1357 H01-1358 H01-1359 H01-1360 H01-1361 H01-1362 H01-1363 H01-1364 H01-1365 H01-1366 H01-1367 H01-1368 H01-1369 H01-1370 H01-1371 H01-1372 H01-1373

SH2D4A DUSP21 LOC63928 FKBPL KIF13A SAMSN1 RRAGC LIN7B ITGB1BP1 RAB38 ZFYVE20 KIF9 EFCBP1 ARL6IP2 GNB1L RAB17 RAB3IP MPP5 CENTD3 TNS RASA1 DUSP6 LOC64744 LPPR2 SMURF2 TENS1 CERK EPS8L2 OSBPL11 DEPDC6 FLJ23588 KLC2 MARCKSL1 RASL11B MGC1136 MGC8407 ZFYVE21 CARD14 PLEKHF1 PLA2G4A NOX5 FYCO1 EFCAB1 HECTD3 ARHGAP10 PPP1R3B PLEKHF2 FLJ12604 ASB13 C20orf23 MCTP1

NP_071354 NP_071359 NP_071380 NP_071393 NP_071396 NP_071419 NP_071440 NP_071448 NP_071729 NP_071732 NP_071735 NP_071737 NP_071746 NP_071769 NP_071891 NP_071894 NP_071901 NP_071919 NP_071926 NP_072174 NP_072179 NP_073143 NP_073570 NP_073574 NP_073576 NP_073585 NP_073603 NP_073609 NP_073613 NP_073620 NP_073622 NP_073733 NP_075385 NP_076429 NP_076930 NP_076951 NP_076976 NP_077015 NP_077286 NP_077734 NP_078781 NP_078789 NP_078869 NP_078878 NP_078881 NP_078883 NP_078889 NP_078897 NP_078977 NP_078980 NP_078993

NM_022071 NM_022076 NM_022097 NM_022110 NM_022113 NM_022136 NM_022157 NM_022165 NM_022334 NM_022337 NM_022340 NM_022342 NM_022351 NM_022374 NM_053004 NM_022449 NM_022456 NM_022474 NM_022481 NM_022648 NM_022650 NM_022652 NM_022733 NM_022737 NM_022739 NM_022748 NM_022766 NM_022772 NM_022776 NM_022783 NM_022785 NM_022822 NM_023009 NM_023940 NM_024025 NM_024046 NM_024071 NM_024110 NM_024310 NM_024420 NM_024505 NM_024513 NM_024593 NM_024602 NM_024605 NM_024607 NM_024613 NM_024621 NM_024701 NM_024704 NM_024717

SH2 DSPc FRQ1 TPR KISc/Smc SAM COG1100 L27/PDZ PTB RAB FYVE kinesin COG1359 GBP WD40 ras Myosin_tail PDZ/SH3/GuKc SAM/PH/ArfGap/RhoGAP PTPc_motif/SH2/PTB SH3/PH/RasGAP RHOD/DSPc ArfGap PAP2 HUL4 SH2/PTB LCB5 PTB/SH3 PH/Oxysterol_BP DEP/PDZ FRQ1 MreC/PilF RAS DSPc S_TKc FYVE Myosin_tail/PDZ/GuKc FYVE PLAc FRQ1/Ferric_reduct RUN/Smc/FYVE FRQ1 HECTc SH3 CBM_21 PH/FYVE PH Arp/ank kinesin/PX C2

H01-1374 H01-1375 H01-1376 H01-1377 H01-1378 H01-1379 H01-1380 H01-1381 H01-1382 H01-1383 H01-1384 H01-1385 H01-1386 H01-1387 H01-1388 H01-1389 H01-1390 H01-1391 H01-1392 H01-1393 H01-1394 H01-1395 H01-1396 H01-1397 H01-1398 H01-1399 H01-1400 H01-1401 H01-1402 H01-1403 H01-1404 H01-1405 H01-1406 H01-1407 H01-1408 H01-1409 H01-1410 H01-1411 H01-1412 H01-1413 H01-1414 H01-1415 H01-1416 H01-1417 H01-1418 H01-1419 H01-1420 H01-1421 H01-1422 H01-1423 H01-1424

C9orf86 MICAL-L2 CLMN NEK11 RABEP2 AYTL2 RIN3 FLJ21687 DOK3 ADCK4 FLJ13265 FLJ11535 RIN3 PDZK7 PLEKHH3 PHC3 MCF2L ARL14 YSK4 LAK RAB11FIP1 LRRC1 DEPDC2 ITPKC TRIB1 EFHD1 I-4 GKAP1 SPTBN4 TNKS2 RAPH1 CENTB5 PTPRO LOC388462 OSBP2 ILKAP SGPP1 STK33 C1orf89 CDADC1 CCNL2 NUAK2 RAB1B CABP2 KIF18A CDC2L5 RAB33B ARHGAP24 COL4A3BP MARK4 C9orf58

NP_078994 NP_078999 NP_079010 NP_079076 NP_079092 NP_079106 NP_079108 NP_079135 NP_079148 NP_079152 NP_079153 NP_079164 NP_079168 NP_079171 NP_079203 NP_079223 NP_079255 NP_079323 NP_079328 NP_079420 NP_079427 NP_079444 NP_079446 NP_079470 NP_079471 NP_079478 NP_079486 NP_079487 NP_079489 NP_079511 NP_079528 NP_085152 NP_109596 NP_109597 NP_110385 NP_110395 NP_110418 NP_112168 NP_112169 NP_112173 NP_112199 NP_112214 NP_112243 NP_112481 NP_112494 NP_112557 NP_112586 NP_112595 NP_112729 NP_113605 NP_113614

NM_024718 NM_024723 NM_024734 NM_024800 NM_024816 NM_024830 NM_024832 NM_024859 NM_024872 NM_024876 NM_024877 NM_024888 NM_024892 NM_024895 NM_024927 NM_024947 NM_024979 NM_025047 NM_025052 NM_025144 NM_025151 NM_025168 NM_025170 NM_025194 NM_025195 NM_025202 NM_025210 NM_025211 NM_025213 NM_025235 NM_025252 NM_030649 NM_030671 NM_030672 NM_030758 NM_030768 NM_030791 NM_030906 NM_030907 NM_030911 NM_030937 NM_030952 NM_030981 NM_031204 NM_031217 NM_031267 NM_031296 NM_031305 NM_031361 NM_031417 NM_031426

ras ERM SAC6 S_TKc Rabaptin FRQ1 VPS9 PDZ IRS AarF cyclin PAP2 SH2 PDZ PH/MyTH4/B41 FCS/SAM SEC14/SPEC/RhoGEF arf S_TKc MHCK_EF2_kinase C2 COG4886 PH/DEP/PDZ IPK S_TKc FRQ1 Smc SAC6/SPEC Arp/SAM/PARP RA/PH PH/ArfGap/Arp PTPc RhoGAP PH/Oxysterol_BP PP2Cc PAP2 S_TKc ras ComEB CYCLIN S_TKc ras FRQ1 kinesin S_TKc RAB RhoGAP PH/START S_TKc/RIO/TyrKc/UBA FRQ1

H01-1425 H01-1426 H01-1427 H01-1428 H01-1429 H01-1430 H01-1431 H01-1432 H01-1433 H01-1434 H01-1435 H01-1436 H01-1437 H01-1438 H01-1439 H01-1440 H01-1441 H01-1442 H01-1443 H01-1444 H01-1445 H01-1446 H01-1447 H01-1448 H01-1449 H01-1450 H01-1451 H01-1452 H01-1453 H01-1454 H01-1455 H01-1456 H01-1457 H01-1458 H01-1459 H01-1460 H01-1461 H01-1462 H01-1463 H01-1464 H01-1465 H01-1466 H01-1467 H01-1468 H01-1469 H01-1470 H01-1471 H01-1472 H01-1473 H01-1474 H01-1475

RASSF5 RPS6KL1 CALN1 URP2 SH3KBP1 USP26 RAB34 CENTG3 NYD-SP11 CCNB1 MAP2K6 RASSF4 STK22D FKSG42 TSSK6 NCALD PLEKHN1 PPP1R1B FLJ23356 TBC1D3B PSD2 SGIP1 GARNL3 SYT3 EFCAB2 CAPNS2 WNK4 PINK1 BRSK1 AP1M1 ARHGAP9 PARD6G PDZK4 KIAA1914 DAB2IP KIF2B USP32 PPP1R9B CAPS2 MYO18B PTP4A3 LNX1 PLEKHA8 BLK EFCAB4B PLCD4 PTPN5 C9orf100 MASTL RAB2B ZFYVE19

NP_113625 NP_113652 NP_113656 NP_113659 NP_114098 NP_114113 NP_114140 NP_114152 NP_114157 NP_114172 NP_114365 NP_114412 NP_114417 NP_114421 NP_114426 NP_114430 NP_115505 NP_115568 NP_115613 NP_115634 NP_115665 NP_115667 NP_115669 NP_115674 NP_115704 NP_115706 NP_115763 NP_115785 NP_115806 NP_115882 NP_115885 NP_115899 NP_115901 NP_115939 NP_115941 NP_115948 NP_115971 NP_115984 NP_115995 NP_115997 NP_116000 NP_116011 NP_116028 NP_116046 NP_116069 NP_116115 NP_116170 NP_116207 NP_116233 NP_116235 NP_116239

NM_031437 NM_031464 NM_031468 NM_031471 NM_031892 NM_031907 NM_031934 NM_031946 NM_031951 NM_031966 NM_031988 NM_032023 NM_032028 NM_032032 NM_032037 NM_032041 NM_032129 NM_032192 NM_032237 NM_032258 NM_032289 NM_032291 NM_032293 NM_032298 NM_032328 NM_032330 NM_032387 NM_032409 NM_032430 NM_032493 NM_032496 NM_032510 NM_032512 NM_032550 NM_032552 NM_032559 NM_032582 NM_032595 NM_032606 NM_032608 NM_032611 NM_032622 NM_032639 NM_001715 NM_032680 NM_032726 NM_032781 NM_032818 NM_032844 NM_032846 NM_032850

C1/RA MIT/S_TKc FRQ1 B41/PH SH3 UBP14/UCH-2 RAB RAS/PH/ArfGap WD40 COG5024 S_TKc RA S_TKc RhoGAP S_TKc FRQ1 PH pkinase TBC Sec7/PH Adap_comp_sub Rap_GAP/CNH C2 FRQ1 FRQ1 S_TKc pkinase S_TKc Adap_comp_sub SH3/PH/RhoGAP PB1/PDZ PDZ PH C2/RasGAP/Smc kinesin FRQ1/UBP12/UCH-2 PDZ/Smc FRQ1 MYSc CDC14 PDZ PH SH3/SH2/TyrKc FRQ1 PH/PLC/C2 PTPc RhoGEF S_TKc/S_TKc RAB FYVE

H01-1476 H01-1477 H01-1478 H01-1479 H01-1480 H01-1481 H01-1482 H01-1483 H01-1484 H01-1485 H01-1486 H01-1487 H01-1488 H01-1489 H01-1490 H01-1491 H01-1492 H01-1493 H01-1494 H01-1495 H01-1496 H01-1497 H01-1498 H01-1499 H01-1500 H01-1501 H01-1502 H01-1503 H01-1504 H01-1505 H01-1506 H01-1507 H01-1508 H01-1509 H01-1510 H01-1511 H01-1512 H01-1513 H01-1514 H01-1515 H01-1516 H01-1517 H01-1518 H01-1519 H01-1520 H01-1521 H01-1522 H01-1523 H01-1524 H01-1525 H01-1526

HSH2D TNS4 ARHGAP19 PPP1R16A RERG SYTL2 STK31 MAPKAPK2 SEC22L3 ARHGEF4 PCTK1 SYDE1 MACF1 RTKN MPP4 RHPN2 STON2 NEK9 MYLK2 PLCZ1 PSKH2 SCIN TRIM23 PPP1R14A ERN2 CDC14A CDC14B CAV3 RGS8 KRAS MYO1C CDC2 MAPK8IP3 PDE5A FCHSD1 ARHGAP18 MRLC2 MGC16733 CCNDBP1 CDC42 CORO2A CDK2 TSSK3 ADCK2 SNAG1 STX1B2 RHPN1 NOSTRIN HAK SNX26 CDK10

NP_116244 NP_116254 NP_116289 NP_116291 NP_116307 NP_116561 NP_116562 NP_116584 NP_116752 NP_127462 NP_148979 NP_149014 NP_149033 NP_149035 NP_149055 NP_149094 NP_149095 NP_149107 NP_149109 NP_149114 NP_149117 NP_149119 NP_150231 NP_150281 NP_150296 NP_201570 NP_201589 NP_203123 NP_203131 NP_203524 NP_203693 NP_203698 NP_203750 NP_246273 NP_258260 NP_277050 NP_291024 NP_291025 NP_411241 NP_426359 NP_438171 NP_439892 NP_443073 NP_443085 NP_443102 NP_443106 NP_443156 NP_443178 NP_443179 NP_443180 NP_443713

NM_032855 NM_032865 NM_032900 NM_032902 NM_032918 NM_032943 NM_032944 NM_032960 NM_032970 NM_032995 NM_033019 NM_033025 NM_033044 NM_033046 NM_033066 NM_033103 NM_033104 NM_033116 NM_033118 NM_033123 NM_033126 NM_033128 NM_033228 NM_033256 NM_033266 NM_033313 NM_033332 NM_033337 NM_033345 NM_033360 NM_033375 NM_033379 NM_033392 NM_033437 NM_033449 NM_033515 NM_033546 NM_033547 NM_037370 NM_044472 NM_052820 NM_052827 NM_052841 NM_052853 NM_052870 NM_052874 NM_052924 NM_052946 NM_052947 NM_052948 NM_052987

SH2 SH2/PTB RhoGAP Arp RAS C2 TUDOR/pkinase S_TKc SH3/RhoGEF S_TKc RhoGAP SAC6/spectrin PH L27/PDZ/SH3/GuKc HR1/BRO1/PDZ Adap_comp_sub S_TKc/ATS1 S_TKc PLC/C2 S_TKc GEL RING/BBC/arf S_TKc/PUG CDC14 CDC14 Caveolin RGS RAS MYSc S_TKc SbcC GAF/PDEase FCH/SH3 RhoGAP FRQ1 Adaptin_N RHO WD40 S_TKc S_TKc AarF/ABC1 SH3/PX Syntaxin HR1/BRO1/PDZ SH3 IG/MHCK_EF2_kinase SH3/RhoGAP S_TKc

H01-1527 H01-1528 H01-1529 H01-1530 H01-1531 H01-1532 H01-1533 H01-1534 H01-1535 H01-1536 H01-1537 H01-1538 H01-1539 H01-1540 H01-1541 H01-1542 H01-1543 H01-1544 H01-1545 H01-1546 H01-1547 H01-1548 H01-1549 H01-1550 H01-1551 H01-1552 H01-1553 H01-1554 H01-1555 H01-1556 H01-1557 H01-1558 H01-1559 H01-1560 H01-1561 H01-1562 H01-1563 H01-1564 H01-1565 H01-1566 H01-1567 H01-1568 H01-1569 H01-1570 H01-1571 H01-1572 H01-1573 H01-1574 H01-1575 H01-1576 H01-1577

TSSK2 GLMN IHPK3 CIB3 DUSP4 CCNE1 UBE2J2 CDKN1A MYO18A CDKN2D MYL1 MYL6 PTP4A2 PTPN2 GNAS GAB2 AP1G2 PTPN6 PTPN7 CAPS PTPN11 DUSP15 GAB3 PTPN13 SYTL4 C20orf152 STK35 PTPRA SOCS4 ASB10 ASB11 ASB5 DUSP19 RAB40A PTPRC ASB14 ASB12 PTPRD PTPRE PTPRF RAB24 RGS18 TPTE2 AP2A1 SNAP23 CPNE4 SNAP25 OPA1 PTPRN2 PTPRR GIPC3

NP_443732 NP_444504 NP_473452 NP_473454 NP_476499 NP_476530 NP_477515 NP_510867 NP_510880 NP_524145 NP_524146 NP_524149 NP_536316 NP_536348 NP_536351 NP_536739 NP_536806 NP_536859 NP_542156 NP_542157 NP_542168 NP_542178 NP_542179 NP_542416 NP_542775 NP_543024 NP_543026 NP_543031 NP_543143 NP_543147 NP_543149 NP_543150 NP_543152 NP_543155 NP_563579 NP_569058 NP_569059 NP_569077 NP_569119 NP_569707 NP_570137 NP_570138 NP_570141 NP_570603 NP_570710 NP_570720 NP_570824 NP_570850 NP_570858 NP_570897 NP_573568

NM_053006 NM_053274 NM_054111 NM_054113 NM_057158 NM_057182 NM_058167 NM_078467 NM_078471 NM_079421 NM_079422 NM_079425 NM_080391 NM_080423 NM_080426 NM_080491 NM_080545 NM_080549 NM_080589 NM_080590 NM_080601 NM_080611 NM_080612 NM_080685 NM_080737 NM_080834 NM_080836 NM_080841 NM_080867 NM_080871 NM_080873 NM_080874 NM_080876 NM_080879 NM_080922 NM_130387 NM_130388 NM_130393 NM_130435 NM_130440 NM_130781 NM_130782 NM_130785 NM_130787 NM_130798 NM_130808 NM_130811 NM_130837 NM_130843 NM_130846 NM_133261

S_TKc IPK FRQ1 DSPc cyclin UQ_con CDI PDZ/MYSc Arp FRQ1 FRQ1 CDC14 PTPc G-alpha PH Adaptin_N/Alpha_adaptinC2 SH2/PTPc PTPc FRQ1 SH2/SH2/PTPc DSPc PH B41/PDZ/PTPc RPH3A_effector/C2 cNMP_binding S_TKc PTPc SH2/SOCS Arp/ank Arp/ank/SOCS Arp/ank DSPc RAB HRD1/FN3/PTPc Arp/SOCS Arp/ank IG/FN3/PTPc PTPc IG/FN3/PTPc ras RGS CDC14 Adaptin_N/Alpha_adaptinC t_SNARE C2/VWA t_SNARE/t_SNARE dynamin PTPc PTPc PDZ

H01-1578 H01-1579 H01-1580 H01-1581 H01-1582 H01-1583 H01-1584 H01-1585 H01-1586 H01-1587 H01-1588 H01-1589 H01-1590 H01-1591 H01-1592 H01-1593 H01-1594 H01-1595 H01-1596 H01-1597 H01-1598 H01-1599 H01-1600 H01-1601 H01-1602 H01-1603 H01-1604 H01-1605 H01-1606 H01-1607 H01-1608 H01-1609 H01-1610 H01-1611 H01-1612 H01-1613 H01-1614 H01-1615 H01-1616 H01-1617 H01-1618 H01-1619 H01-1620 H01-1621 H01-1622 H01-1623 H01-1624 H01-1625 H01-1626 H01-1627 H01-1628

FER1L3 PLCD3 GEFT NEK7 SYN3 RHOV ZAK HPCAL1 CREB1 RPIB9 LRSAM1 KIF12 FAM83F ARL11 RAB3C KIF23 PP1R8 CTTN GGA3 GGA2 PPP1R14B CALML6 RHOT2 SYTL5 ARL8A MAPK1 MAPK10 MYO3B MAPK14 MAPK15 MAPK7 MAPK8 EPS8L3 CSNK1D MAPK9 MAPKAPK5 ALS2CR7 CENTD2 CENTD1 EPS8L1 GRK7 FGD4 PPM1L ADCY4 AKAP1 STAT3 TA-PP2C AKAP4 AMPH YWHAB BIN1

NP_579899 NP_588614 NP_597840 NP_598001 NP_598344 NP_598378 NP_598407 NP_602293 NP_604391 NP_612147 NP_612370 NP_612433 NP_612444 NP_612459 NP_612462 NP_612565 NP_612568 NP_612632 NP_619525 NP_619581 NP_619634 NP_619650 NP_620124 NP_620135 NP_620150 NP_620407 NP_620448 NP_620482 NP_620583 NP_620590 NP_620603 NP_620637 NP_620641 NP_620693 NP_620709 NP_620777 NP_631897 NP_631920 NP_631921 NP_631943 NP_631948 NP_640334 NP_640338 NP_640340 NP_644804 NP_644805 NP_644812 NP_647450 NP_647477 NP_647539 NP_647601

NM_133337 NM_133373 NM_133483 NM_133494 NM_133633 NM_133639 NM_133646 NM_134421 NM_134442 NM_138290 NM_138361 NM_138424 NM_138435 NM_138450 NM_138453 NM_138555 NM_138558 NM_138565 NM_138619 NM_138640 NM_138689 NM_138705 NM_138769 NM_138780 NM_138795 NM_138957 NM_138982 NM_138995 NM_139014 NM_139021 NM_139034 NM_139049 NM_139053 NM_139062 NM_139070 NM_139078 NM_139158 NM_139181 NM_139182 NM_139204 NM_139209 NM_139241 NM_139245 NM_139247 NM_139275 NM_139276 NM_139283 NM_139289 NM_139316 NM_139323 NM_139351

C2/DysFN/C2 PH/PLC RhoGEF S_TKc Synapsin RHO pkinase FRQ1 pKID/bZIP RUN ERM kinesin Cls arf ras kinesin/Smc HS1_rep/SH3 VHS/GAT/Alpha_adaptinC2 VHS FRQ1 RHO/ras RPH3A_effector/C2 arf S_TKc S_TKc S_TKc/MYSc S_TKc S_TKc S_TKc S_TKc PTB/SH3 pkinase S_TKc S_TKc S_TKc PH/ArfGap/RhoGAP PH/RhoGAP/PH PTB/SH3 RGS/S_TKc RhoGEF/FYVE/PH PP2Cc guanylate_cyc STAT/STAT_bind/SH2 PTC1 BAR/SH3 14-3-3 BAR/SH3

H01-1629 H01-1630 H01-1631 H01-1632 H01-1633 H01-1634 H01-1635 H01-1636 H01-1637 H01-1638 H01-1639 H01-1640 H01-1641 H01-1642 H01-1643 H01-1644 H01-1645 H01-1646 H01-1647 H01-1648 H01-1649 H01-1650 H01-1651 H01-1652 H01-1653 H01-1654 H01-1655 H01-1656 H01-1657 H01-1658 H01-1659 H01-1660 H01-1661 H01-1662 H01-1663 H01-1664 H01-1665 H01-1666 H01-1667 H01-1668 H01-1669 H01-1670 H01-1671 H01-1672 H01-1673 H01-1674 H01-1675 H01-1676 H01-1677 H01-1678 H01-1679

MATK RGS3 AKAP12 GNAT1 ZFYVE27 RHEBL1 PPM1M CAPSL PXDNL WDR66 HIPK4 C3orf48 AKAP13 SOCS5 FLJ30058 ANKRD23 ARL13B STK32A TSNARE1 C10orf9 CDC42EP5 STAC3 CISH MAP2K5 DIRAS1 MAP2K7 CABP4 CSNK1A1L VTI1A C14orf143 STYX ACVR1C PLEKHK1 MAP3K6 OSBPL3 MAP3K7 MAP3K7IP2 MAP4K4 YWHAZ AP1B1 PHLDB2 KIFC2 CHEK2 ASB3 ANKS4B ANXA11 ASB4 PALM2-AKAP2 ITSN2 PPP3R2 AKAP9

NP_647612 NP_652760 NP_653080 NP_653082 NP_653189 NP_653194 NP_653242 NP_653248 NP_653252 NP_653269 NP_653286 NP_653315 NP_658913 NP_659198 NP_659404 NP_659431 NP_659433 NP_659438 NP_659440 NP_659449 NP_659494 NP_659501 NP_659508 NP_660145 NP_660156 NP_660186 NP_660201 NP_660204 NP_660207 NP_660274 NP_660294 NP_660302 NP_660350 NP_663159 NP_663164 NP_663306 NP_663317 NP_663720 NP_663723 NP_663782 NP_665696 NP_665697 NP_665861 NP_665862 NP_665872 NP_665876 NP_665879 NP_671492 NP_671494 NP_671709 NP_671714

NM_139355 NM_144489 NM_144497 NM_144499 NM_144588 NM_144593 NM_144641 NM_144647 NM_144651 NM_144668 NM_144685 NM_144714 NM_144767 NM_144949 NM_144967 NM_144994 NM_144996 NM_145001 NM_145003 NM_145012 NM_145057 NM_145064 NM_145071 NM_145162 NM_145173 NM_145185 NM_145200 NM_145203 NM_145206 NM_145231 NM_145251 NM_145259 NM_145307 NM_145319 NM_145324 NM_145333 NM_145342 NM_145687 NM_145690 NM_145730 NM_145753 NM_145754 NM_145862 NM_145863 NM_145865 NM_145869 NM_145872 NM_147150 NM_147152 NM_147180 NM_147185

SH3/SH2/TyrKc RGS G-alpha FYVE RAS PP2Cc FRQ1 An_peroxidase/vwc WD40/FRQ1 S_TKc PP2Cc RhoGEF SH2/SOCS RhoGAP NLS/Arp/ank arf S_TKc COG5325 cyclin C1/SH3 SH2/SOCS S_TKc RAS S_TKc FRQ1 pkinase FRQ1 DSPc Activin_recp/GS/pkinase PH S_TKc PH/Oxysterol_BP pkinase CUE S_TKc/CNH 14-3-3 Adaptin_N/Alpha_adaptinC2 Smc/PH KISc FHA/S_TKc Arp/ANK/SOCS Arp/SAM annexin Arp/ank EH/Smc/SH3 FRQ1 Smc/NtpI

H01-1680 H01-1681 H01-1682 H01-1683 H01-1684 H01-1685 H01-1686 H01-1687 H01-1688 H01-1689 H01-1690 H01-1691 H01-1692 H01-1693 H01-1694 H01-1695 H01-1696 H01-1697 H01-1698 H01-1699 H01-1700 H01-1701 H01-1702 H01-1703 H01-1704 H01-1705 H01-1706 H01-1707 H01-1708 H01-1709 H01-1710 H01-1711 H01-1712 H01-1713 H01-1714 H01-1715 H01-1716 H01-1717 H01-1718 H01-1719 H01-1720 H01-1721 H01-1722 H01-1723 H01-1724 H01-1725 H01-1726 H01-1727 H01-1728 H01-1729 H01-1730

OSBPL9 EPN2 CSNK1E IPMK CDC42EP1 SYT11 C9orf111 FLJ40342 SGPP2 PTPDC1 FRMPD2 FLJ32810 SAMD11 DUSP18 FLJ40432 ALS2CR19 NEK10 FGD5 DKFZp761G058 RASGEF1B SH3RF2 RASEF SPRED1 DCAMKL2 MGC39715 KNDC1 MLKL RALGPS2 PLD5 HIPK1 MGC26597 NEK3 DOK6 CPNE2 PDIK1L ARPC2 PTK7 DKFZp434K1815 DGKH CPNE1 LOC129285 SPATA13 FYN MTMR3 KIF19 ARHGEF19 SIPA1 SYT14 PLCXD2 SH3PX3 IHPK1

NP_683707 NP_683723 NP_689407 NP_689416 NP_689449 NP_689493 NP_689499 NP_689560 NP_689599 NP_689635 NP_689641 NP_689645 NP_689699 NP_689724 NP_689736 NP_689739 NP_689747 NP_689749 NP_689755 NP_689758 NP_689763 NP_689786 NP_689807 NP_689832 NP_689841 NP_689856 NP_689862 NP_689876 NP_689879 NP_689909 NP_689913 NP_689933 NP_689934 NP_689940 NP_690048 NP_690601 NP_690621 NP_690852 NP_690874 NP_690908 NP_694539 NP_694568 NP_694593 NP_694691 NP_694941 NP_694945 NP_694985 NP_694994 NP_695000 NP_695003 NP_695005

NM_148909 NM_148921 NM_152221 NM_152230 NM_152243 NM_152280 NM_152286 NM_152347 NM_152386 NM_152422 NM_152428 NM_152432 NM_152486 NM_152511 NM_152523 NM_152526 NM_152534 NM_152536 NM_152542 NM_152545 NM_152550 NM_152573 NM_152594 NM_152619 NM_152628 NM_152643 NM_152649 NM_152663 NM_152666 NM_152696 NM_152700 NM_152720 NM_152721 NM_152727 NM_152835 NM_152862 NM_152882 NM_152892 NM_152910 NM_152931 NM_152994 NM_153023 NM_153048 NM_153051 NM_153209 NM_153213 NM_153253 NM_153262 NM_153268 NM_153271 NM_153273

PH/Oxysterol_BP ENTH pkinase IPK/IPK C2 cNMP_binding/RssA FRQ1 PAP2 CDC14 PDZ RhoGAP SAM DSPc cyclin PDZ S_TKc RhoGEF/PH/FYVE PP2Cc RasGEF RING/SH3 FRQ1 WH1 DCX/S_TKc PX/B41 RasGEF TyrKc PH Cls S_TKc PIPKc S_TKc PTBI C2/VWA S_TKc p34-Arc IG/TyrKc COG4886/WD40 PH/C1/DAGK C2/VWA SH3/RhoGEF SH3/TyrKc PTPc_motif/FYVE kinesin RhoGEF Rap_GAP/PDZ/Smc C2 PI-PLC-X SH3/PX IPK

H01-1731 H01-1732 H01-1733 H01-1734 H01-1735 H01-1736 H01-1737 H01-1738 H01-1739 H01-1740 H01-1741 H01-1742 H01-1743 H01-1744 H01-1745 H01-1746 H01-1747 H01-1748 H01-1749 H01-1750 H01-1751 H01-1752 H01-1753 H01-1754 H01-1755 H01-1756 H01-1757 H01-1758 H01-1759 H01-1760 H01-1761 H01-1762 H01-1763 H01-1764 H01-1765 H01-1766 H01-1767 H01-1768 H01-1769 H01-1770 H01-1771 H01-1772 H01-1773 H01-1774 H01-1775 H01-1776 H01-1777 H01-1778 H01-1779 H01-1780 H01-1781

UBE1 LYK5 MGC42105 LNX2 CAMK1D Rgr CPNE9 FAM43A CABYR RASGRF1 RASGRP2 MINK1 RASGRP4 RASGRP3 SGK2 SGK3 RASSF1 TENC1 RASSF2 CAMK2A USP2 RAB39B CAMK2B CAMK2D CAMK2G CAMKK1 IL16 CAPN3 PTK2B SNF1LK UBE2Q2 USH1G CNTD PIP5KL1 MPP7 TTBK2 EFCAB3 CNKSR3 FLJ38964 CNBD1 ANKS6 FGD2 STK32C KSR2 RNF149 EPHA6 ARL10 ARHGEF15 PDZD8 LOC201175 TSSK4

NP_695012 NP_699166 NP_699192 NP_699202 NP_705718 NP_705843 NP_705899 NP_710157 NP_722452 NP_722522 NP_722541 NP_722549 NP_733749 NP_733772 NP_733794 NP_733827 NP_733835 NP_736610 NP_739580 NP_741960 NP_741994 NP_741995 NP_742081 NP_742126 NP_751913 NP_757343 NP_757366 NP_775110 NP_775268 NP_775490 NP_775740 NP_775748 NP_775749 NP_775763 NP_775767 NP_775771 NP_775774 NP_775786 NP_775798 NP_775809 NP_775822 NP_775829 NP_775846 NP_775869 NP_775918 NP_775926 NP_775935 NP_776089 NP_776152 NP_777579 NP_777604

NM_153280 NM_153335 NM_153361 NM_153371 NM_153498 NM_153615 NM_153635 NM_153690 NM_153768 NM_153815 NM_153819 NM_153827 NM_170604 NM_170672 NM_170693 NM_170709 NM_170717 NM_170754 NM_170774 NM_171825 NM_171997 NM_171998 NM_172084 NM_172128 NM_172173 NM_172206 NM_172217 NM_173087 NM_173176 NM_173354 NM_173469 NM_173477 NM_173478 NM_173492 NM_173496 NM_173500 NM_173503 NM_173515 NM_173527 NM_173538 NM_173551 NM_173558 NM_173575 NM_173598 NM_173647 NM_173655 NM_173664 NM_173728 NM_173791 NM_174919 NM_174944

ThiF/UBACT S_TKc S_TKc RAD18/PDZ S_TKc RasGEF C2/VWA PTB RIIa RasGEFN/RasGEF RasGEF/DAG_PE-bind S_TKc/CNH RasGEF/DAG_PE-bind RasGEF/DAG_PE-bind S_TKc PX/S_TKc DAG_PE-bind C1/SH2/PTB RA S_TKc UBP5 RAB S_TKc S_TKc S_TKc S_TKc PDZ CysPc/Calpain_III/FRQ1 B41/TyrKc/Focal_AT S_TKc UQ_con Arp/SAM cyclin PIPKc L27/PDZ/SH3/GuKc pkinase FRQ1 SAM/PDZ ras cNMP_binding SAM RhoGEF/FYVE/PH S_TKc pkinase PA/COG5540 TyrKc arf RhoGEF PDZ/DAG_PE-bind SH3 S_TKc

H01-1782 H01-1783 H01-1784 H01-1785 H01-1786 H01-1787 H01-1788 H01-1789 H01-1790 H01-1791 H01-1792 H01-1793 H01-1794 H01-1795 H01-1796 H01-1797 H01-1798 H01-1799 H01-1800 H01-1801 H01-1802 H01-1803 H01-1804 H01-1805 H01-1806 H01-1807 H01-1808 H01-1809 H01-1810 H01-1811 H01-1812 H01-1813 H01-1814 H01-1815 H01-1816 H01-1817 H01-1818 H01-1819 H01-1820 H01-1821 H01-1822 H01-1823 H01-1824 H01-1825 H01-1826 H01-1827 H01-1828 H01-1829 H01-1830 H01-1831 H01-1832

SLA2 ARFGAP1 TPO SYT9 RAB37 RHOC TXLNA KIS EXOC8 DUOX1 MTMR1 PDLIM2 INADL PPAP2A SYT2 RAB7B PPAP2B KLC3 PPFIA1 STX12 RASSF6 PPAP2C CSNK2A1 PPM1A DOK5 PPM1B ARL6 PPM1G PAK7 ASB6 PPP2R4 PLA2G4D NEK8 SPTBN1 CDC2L2 IRS2 YWHAE LOC389842 DFNB31 KIAA0674 L3MBTL3 ANKRD13 MAP3K9 ZFYVE1 DMWD SLC25A25 PPFIA3 RASGRF2 STK40 RANBP6 PPP2R2C

NP_778252 NP_783202 NP_783653 NP_783860 NP_783865 NP_786886 NP_787048 NP_787062 NP_787072 NP_787954 NP_789746 NP_789847 NP_795353 NP_795714 NP_796376 NP_796377 NP_803133 NP_803136 NP_803172 NP_803173 NP_803876 NP_808211 NP_808228 NP_808821 NP_808874 NP_808907 NP_816931 NP_817092 NP_817127 NP_821066 NP_821070 NP_828848 NP_835464 NP_842565 NP_076916 NP_003740 NP_006752 XP_372200 NP_056219 XP_376903 NP_115814 NP_149112 NP_149132 NP_067083 NP_004934 NP_443133 NP_003651 NP_008840 NP_114406 NP_036548 NP_065149

NM_175077 NM_175609 NM_175722 NM_175733 NM_175738 NM_175744 NM_175852 NM_175866 NM_175876 NM_175940 NM_176789 NM_176871 NM_176878 NM_176895 NM_177402 NM_177403 NM_177414 NM_177417 NM_177423 NM_177424 NM_177532 NM_177543 NM_177560 NM_177952 NM_177959 NM_177968 NM_177976 NM_177983 NM_177990 NM_177999 NM_178003 NM_178034 NM_178170 NM_178313 NM_024011 NM_003749 NM_006761 XM_372200 NM_015404 XM_376903 NM_032438 NM_033121 NM_033141 NM_021260 NM_004943 NM_052901 NM_003660 NM_006909 NM_032017 NM_012416 NM_020416

SH3/SH2 ArfGap An_peroxidase/CCP/EGF_CA C2 ras RHO Smc pkinase/RRM PH An_peroxidase/FRQ1/Ferric_reduct GRAM/PTPc_motif PDZ/LIM PDZ PAP2 C2 RAB PAP2 Smc/SAM COG5325 RA PAP2 S_TKc PP2Cc PTBI PP2Cc arf PP2Cc PBD/S_TKc ank PTPA PLA2_B S_TKc/ATS1 SAC6/SPEC S_TKc/TyrKc PH/IRS_PTBI 14_3_3 RanBD PDZ Myosin_tail/SbcC/Smc/ERM MBT/SAM ANK TyrKc/S_TKc GBP/FYVE WD40 FRQ1 Smc/SAM RasGEF/RhoGEF/PH S_TKc ARM/KAP95 WD40/CDC55

H01-1833 H01-1834 H01-1835 H01-1836 H01-1837 H01-1838 H01-1839 H01-1840 H01-1841 H01-1842 H01-1843 H01-1844 H01-1845 H01-1846 H01-1847 H01-1848 H01-1849 H01-1850 H01-1851 H01-1852 H01-1853 H01-1854 H01-1855 H01-1856 H01-1857 H01-1858 H01-1859 H01-1860 H01-1861 H01-1862 H01-1863 H01-1864 H01-1865 H01-1866 H01-1867 H01-1868 H01-1869 H01-1870 H01-1871 H01-1872 H01-1873 H01-1874 H01-1875 H01-1876 H01-1877 H01-1878 H01-1879 H01-1880 H01-1881 H01-1882 H01-1883

PARD6B LOC90342 PLEKHH1 WDR22 SHD MAST1 SIPA1L3 SHF C21orf25 MICAL3 DLGAP3 FAM62B LOC440804 CABLES2 DUSP7 WDR18 MAST3 LOC91461 UNC13A DUSP16 MICAL-L1 ARHGAP20 SNF1LK2 SHC2 MAP3K1 ROPN1B PLCH1 USP22 SH3RF1 SOS2 PDP2 PIK3R1 GAPVD1 ULK3 MTMR7 CIT NEDD4 C20orf74 PPFIA4 WDR75 PIP5K1C ZAP70 RUSC2 KIAA1026 SWAP70 KIF26A DNMBP PPM1H LPPR4 DOCK10 FNBP1

NP_115910 XP_001127410 NP_065766 NP_003852 NP_064594 NP_055790 NP_055888 NP_612365 XP_032945 NP_065844 XP_035601 NP_065779 XP_036936 NP_112492 NP_001938 NP_077005 XP_038150 NP_612379 XP_038604 NP_085143 NP_203744 NP_065860 NP_056006 XP_001129272 XP_042066 NP_001012337 NP_055811 XP_042698 NP_065921 NP_008870 NP_065837 NP_852556 NP_056450 NP_056333 NP_004677 NP_009105 NP_006145 NP_065076 NP_055868 NP_115544 NP_036530 NP_001070 NP_055621 NP_056024 NP_055870 XP_050278 NP_056036 XP_350881 NP_055654 NP_055504 NP_055848

NM_032521 XM_001127410 NM_020715 NM_003861 XM_031857 NM_014975 NM_015073 NM_138356 XM_032945 NM_020793 XM_035601 NM_020728 XM_036936 NM_031215 NM_001947 NM_024100 XM_038150 NP_612379 XM_038604 NM_030640 NM_033386 NM_020809 NM_015191 XM_001129272 XM_042066 NM_001012337 NM_014996 XM_042698 NM_020870 NM_006939 NM_020786 NM_181504 NM_015635 NM_015518 NM_004686 NM_007174 NM_006154 NM_020343 NM_015053 NM_032168 NM_012398 NM_001079 NM_014806 NM_015209 NM_015055 XM_050278 NM_015221 XM_350880 NM_014839 NM_014689 NM_015033

PB1/PDZ C2 PH/MyTH4/B41 WD40 SH2 S_TKc/PDZ Rap_GAP/PDZ SH2 C2 SAC6/CH/LIM GKAP C2 SH3/FN3 CYCLIN DSPc/DSP_MapKP WD40 S_TKc/TyrKc/PDZ pkinase/S_TKc/TyrKc C2/C2 DSPc/DSP_MapKP CH RhoGAP SPS1/S_TKc PTB/SH2 RIIa FRQ1/PLC/C2 UBP14 RING/SH3 RasGEF PP2C SH2 RasGAP/VPS9 S_TKc/TyrKc PTPc_motif Smc/S_TKc/C1/PH/CNH C2/WW/HUL4/PRP40/HECTc Rap_GAP SAM WD40 PIPKc SH2/TyrKc RUN/SH3 Smc/ERM PH KISc/kinesin SH3/RhoGEF/BAR PP2C/PTC1 PAP2/acidPPc/PgpB PH SH3

H01-1884 H01-1885 H01-1886 H01-1887 H01-1888 H01-1889 H01-1890 H01-1891 H01-1892 H01-1893 H01-1894 H01-1895 H01-1896 H01-1897 H01-1898 H01-1899 H01-1900 H01-1901 H01-1902 H01-1903 H01-1904 H01-1905 H01-1906 H01-1906 H01-1907 H01-1908 H01-1909 H01-1910 H01-1911 H01-1912 H01-1913 H01-1914 H01-1915 H01-1916 H01-1917 H01-1918 H01-1919 H01-1920

FGD3 PCTK3 NA MAPK3 LMTK3 ATG16L2 ANKS3 LOC126520 SFN SRGAP2 IQGAP3 CIB4 FAM58A FLJ36748 NCF1 ANKRD19 PNCK TCHHL1 SHE NA NA NA NA YWHAZ NA NA LOC647279 PLA2G4E LNX1 NA LOC124685 LOC390801 KA36 NA KIAA1957 RALBP1 NA NA

XP_053487 NP_002587 XP_054936 NP_002737 XP_055866 NP_203746 NP_597707 NP_001011716 NP_006133 NP_056141 NP_839943 NP_001025052 NP_689487 NP_689619 NP_000256 NP_001010925 NP_940854 NP_001008536 NP_001010846 XP_060271 XP_060609 XP_061562 XP_062204 NP_003397 XP_062330 XP_062867 XP_935434 XP_523058 NP_116011 XP_064197 XP_064265 XP_064336 NP_872303 XP_064635 XP_065166 NP_006779 XP_065311 XP_065724

XM_053487 NM_002596 XM_054936 NM_002746 XM_055866 NM_033388 NM_133450 NM_001011716 NM_006142 NM_015326 XM_059223 NM_001029881 NM_152274 NM_152406 NM_000265 NM_001010925 NM_198452 NM_001008536 NM_001010846 XM_060271 XM_060609 XM_061562 XM_062204 NM_003406 XM_062330 XM_062867 XM_930341 XM_523058 NM_032622 XM_064197 XM_064265 XM_064336 NM_182497 XM_064635 XM_065166 XM_065279 XM_065311 XM_065724

RhoGEF/PH/FYVE S_TKc DSPc S_TKc/TyrKc TyrKc/SPS1/S_TKc WD40 ANK/SAM /S_TKc 14_3_3 RhoGAP/SH3 IQG1/RasGAP FRQ1/EFh CYCLIN PH PX/SH3 ANK S_TKc S_100/MDN1 SH2 SPEC RA 14-3-3/BMH1 14-3-3/BMH1 ARF/SAR/RAB SPS1/pkinase/S_TKc/TyrKc PLA2_B PDZ FRQ1/Efh FRQ1 S_100 filament/ERM/Smc RHO/ras C2 RhoGAP/ARID PI3_PI4_kinase/PI3Kc/TEL1 RA

NA indicates that the refseq accession number was recently removed during the genome annotation process