Caspofungin Disk Diffusion Breakpoints and Quality Control
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Caspofungin Disk Diffusion Breakpoints and Quality Control
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Caspofungin Disk Diffusion Breakpoints and Quality Control䌤 Steven D. Brown* and Maria M. Traczewski The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, Oregon 97070 Received 11 February 2008/Returned for modification 11 March 2008/Accepted 2 April 2008
Interpretive disk diffusion breakpoints for caspofungin are proposed by evaluating 762 isolates of Candida spp., representing 10 different species obtained as part of the caspofungin clinical trials. Standardized broth microdilution reference tests were compared to the zone diameters observed with 5-g caspofungin disks produced by two different disk manufacturers. Disk diffusion breakpoints of >11 mm for susceptible are proposed. Compared to results from MIC testing, these zone diameters produced error rates that were
