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Model parameters. Parameter. Value. Description. Source. VES. 0.4. Reduction in susceptibility from vaccination. [1]. VEI. 0.4. Reduction in infectiousness from ...

Table S1. Model parameters Parameter VES

Value 0.4

VEI

0.4

VEP

0.667

τ R0 Rmin m

28 days 1.4–1.85 0.8 0.5

psymp

0.67

sympTratio 0.25 vi

Description Reduction in susceptibility from vaccination Reduction in infectiousness from vaccination Reduction in becoming symptomatic upon infection from vaccination Time for a vaccine to reach full efficacy Basic reproductive number in-season Reproductive number out-of-season ratio of asymptomatic to symptomatic infectiousness probability of becoming symptomatic given infection Ratio of travel probability of travel of symptomatic to asymptomatic Relative infectiousness on day i

Source [1] [1] [1]

[2]

[3–4]

[1] Basta NE, Halloran ME, Matrajt L, Longini IM Jr (2008) Estimating influenza vaccine efficacy from challenge and community-based study data. Am J Epidemiol 168: 1343–52. [2] Carrat F, Vergu E, Ferguson NM, Lemaitre M, Cauchemez S, et al. (2008) Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 167: 775–85. [3] Murphy BR, Rennels MB, Douglas RG Jr, Betts RF, Couch RB, et al. (1980) Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers. Infect Immun 29:348–55. [4] Baccam P, Beauchemin C, Macken CA, Hayden FG, Perelson AS (2006) Kinetics of influenza A virus infection in humans. J Virol 80: 7590–9.