Multi-label 2 Ð¸ -regularized logistic regression for ...

Multi-label  2 -regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks

Suyu Mei①*, Kun Zhang②#

①

Software College, Shenyang Normal University, Shenyang, 110034, China

②

Department of Computer Science, Xavier University of Louisianan, New Orleans, LA 70125, USA

Correspondence:

∗

[email protected], #[email protected]

Reactome validation 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76

2016/4/8 19:13

PTK2 ROCK1 [activation] MAPK1 SOS1 [activation] MYC SMAD2 [activation] CXCR4 STAT3 [activation] NFATC2 PPP3CB [activation] MAPK14 SLC9A1 [activation] EPOR PTPN11 [activation;inhibition] PRKCD RAF1 [activation] FGF9 FGFR1 [activation] GNA12 RASA2 [activation] MMP9 PLG [activation;inhibition] MFNG NOTCH1 [activation] RAC1 RASGRF1 [activation] RAC1 WASF2 [activation] ITGA5 TNC [activation] LCP2 PTPN6 [activation;inhibition] LIMK1 PAK2 [activation] FGF4 FGFR4 [activation] RIPK1 TRAF2 [activation] RAPGEF4 RIMS2 [activation] FYN JUP [activation] ANAPC11 CDC23 [activation] EFNA5 EPHA5 [activation] APP MAPK11 [activation] DVL2 RHOA [activation] EIF2B2 EIF2S1 [activation] GSK3B ILK [activation] ITGAV SPP1 [activation] CCNE1 FOXM1 [activation] IKBKB TNF [activation] LAT ZAP70 [activation] ACVR1 BMP2 [activation] CTNNB1 GNA13 [activation] MAP2K6 TLR3 [activation] LTB LTBR [activation] EIF4E RPS6KB1 [activation] DOK2 RASA1 [activation] KLRK1 RAET1E [activation] KLRK1 MICA [activation] NFATC1 PPP3R1 [activation] ACVR1 SMAD9 [activation;inhibition] F11R MLLT4 [activation] CCR5 GNAI3 [activation] MAP3K7 RELA [activation] CREB1 CREBBP [activation] PARD6G RAC1 [activation] AURKB DES [activation] GAB2 SHC1 [activation] ITGA2B VWF [activation] HSPG2 ITGB1 [activation] CCL3L1 CCR5 [activation] LYN PRKCD [activation] FKBP1A PPP3CA [inhibition] BIRC3 CASP1 [activation] MAPKAPK2 TSC2 [activation] ROBO2 SLIT2 [activation] ILK ITGB3 [activation] CISH PRLR [inhibition] IKBKG PRKCB [activation] PRKCE TRPV1 [activation] FLNA IKBKB [activation] NRAS RASSF5 [activation] FGG SERPINA5 [inhibition] IHH PTCH1 [activation] PIK3R1 RRAS2 [activation] FADD STAT1 [activation] NCF1 PAK1 [activation] FGF18 FGFR2 [activation] CCL24 CCR3 [activation] GNAS LHCGR [activation] FGF7 FGFR4 [activation] RASGRF1 RHOA [activation] AMH AMHR2 [activation] MYB NCOR1 [activation] ERBB3 NRG1 [activation] FGF18 FGFR3 [activation] 页 1 共 20


ESR1 POU4F1 FRS2 NTRK1 MAPK1 RARA ACTB WASF3 BMP6 SMAD5 NR3C1 SMAD3 F2R SNX1 CCND1 RBL1 CIT RHOA LIMK1 ROCK1 COL1A1 ITGA5 SNAP23 VAMP2 FRS2 PTPN11 NOTCH4 RBPJ RAC1 VAV3 PORCN WNT6 HDAC1 LEF1 FBXW11 GLI2 IL6ST PIK3R1 PIK3CA RPS6KB1 DUSP7 MAPK1 CDK2 FZR1 CASP8 CHUK CNR1 GNAI2 AKT3 PDPK1 SNAP25 SYT1 NTRK1 SHC3 INSR PTPRF LHB LHCGR BCL2L1 MAPK8 ETS1 MAPK1 ILK ITGB1 MAP2K4 MAPK1 CSNK2B NFKBIA ATG10 ATG5 FLT4 SHC3 CASP6 TFAP2A JAK3 SOCS1 GRB2 SHC2 ITGA4 PRKACA PAK2 RAC1 BID CASP8 MAPK1 SMAD4 CD14 TLR4 CSNK2A1 NFKBIA MARCKS PRKCA IRS2 PIK3CD FGF6 FGFR1 TGFB2 TGFBR1 PTK2 PTK2B CASP10 CASP7 CALM1 CAMKK1 EFNA1 EPHA5 ARHGAP8 RHOA MAPKAPK2 MAPK1 RB1 BID MAPK8 FGF3 FGFR4 ROBO1 SRGAP1 EFNB2 EPHB4 CTF1 LIFR PTPN2 STAT3 FRS2 GRB2 MAPK14 STAT4 IGF1R IGF2 EPHB2 SDC2 ARFGAP1 COPA RASSF5 STK4 MAPKAPK2 JAK2 NFKBIA EP300 TP73 ANAPC2 FZR1 CHUK PEBP1 CXCL6 CXCR1 NTRK2 SHC2 HDAC1 SP1

2016/4/8 19:13 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] SRF [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] YWHAZ [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] 页 2 共 20


RRAS FRS3 SP1 ACTB HRAS ERBB3 CCR5 PLD1 CAV1 HLA-G AKT1 TBK1 DUSP8 GNAI1 CHEK2 PRKACA CHEK2 CSF3R BCL2L11 JAK1 RAC1 MAPK8 BCL2 NTRK1 NCF1 MAF HHIP ITGA9 ACVR1B CASP6 CSF2RB RAC1 BTK BCL6 SOCS1 CRK PLK1 DDX54 NLGN2 MAPK3 CBLB LATS2 CD55 KLRC1 CXCR4 PAK7 CAMK4 MAPK14 DCC KSR1 CSNK1A1 FGF23 CTTN CD4 F5 DNAJB1 LIFR CDH2 AR EFNA2 OXT ARHGAP1 ERBB3 FZD1 F2R BAD GAB1 HLA-E PIK3R1 FSHB CCL8 CCL1 ABL1 COL1A2 CRHR1 GNB2L1

SOS1 GRB2 TP53 RAC2 RASGRP1 PIK3R1 GNAO1 RALA TNF KIR2DL4 PRKDC TICAM1 MAPK9 OPRD1 NBN RAP1B TP53BP1 SOCS3 MAPK10 PDGFRA TRAF6 MAPK9 SOD1 SH2B2 PRKCA MYB SHH SPP1 BAMBI VIM STAT3 VAV2 PLCG2 IRF4 TIRAP IRS1 TPT1 ESR1 NRXN1 NTRK1 FYN STK3 FYN PTPN6 PTK2 RAC1 CAMKK2 PLA2G4A PITPNA YWHAZ CTNNB1 FGFR3 SRC LAT PROC HSPA1A PTPN6 PIK3R1 GSK3B EPHA5 OXTR RAC1 PIK3R2 WNT3 GNA15 BCL2 MAPK3 KLRC2 ZAP70 FSHR CCR3 CCR8 WASF2 ITGB3 GNAS PRKCD

2016/4/8 19:13 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 3 共 20


2016/4/8 19:13

FGF3 FGFR1 [activation] MYC SMAD3 [activation] CREB1 RPS6KA3 [activation] DAPP1 SRC [activation] CDC42 WASF1 [activation] CDKN2A MAPK8 [activation] CD247 LAT [activation] EFNA4 EPHA6 [activation] PIK3R1 PLCG2 [activation] KLRC1 PTPN11 [activation] RHOC ROCK1 [activation] MAP3K14 MAP3K7 [activation] MAPK14 NFATC1 [activation] IRS1 NTRK1 [activation] AR FOXO1 [activation] F8 PROS1 [inhibition] ANAPC11 CDC16 [activation] CXXC4 DVL1 [inhibition] BIRC3 MAP3K14 [activation;inhibition] CXCR2 GNAI2 [activation] JAK1 STAT2 [activation] MAPK1 PTPN5 [inhibition] CDK5 PPP1R1B [activation] AKT2 PDPK1 [activation] GNAI2 MTNR1A [activation] EIF2B3 EIF2S2 [activation] DUSP2 MAPK1 [inhibition] AKT1 PTPN1 [activation] RAB5A RAB7A [activation] ANAPC1 ANAPC4 [activation] NLGN1 NRXN3 [activation] CTNND1 FER [activation;inhibition] DAG1 LAMA1 [activation] CSK DOK1 [activation] JUND MAPK9 [activation] CTSG F2RL2 [activation] PDPK1 PKN1 [activation] EFNB1 EPHB2 [activation] CAMK2G STAT1 [activation] F2RL2 F2RL3 [activation] CDK2 SKP1 [inhibition] MDM2 PPP2R4 [activation] PXN SDC4 [activation] MAPK12 MAPT [activation] LEF1 NLK [inhibition] MTOR TRAF2 [activation] EPHA2 PTK2 [activation] AURKA PRKACA [activation] EP300 TWIST1 [activation] CASP8 IKBKB [activation] ACTG1 VASP [activation] ARHGEF12 GNA13 [activation] CHEK2 RNF8 [activation] BDKRB1 GNAQ [activation] IL2RG STAT1 [activation] NCF1 PRKCB [activation] EIF4E EIF4EBP1 [inhibition] BRAF MAPK1 [activation] GRB2 MAPK1 [activation] FGF4 FGFR1 [activation] AKT1 TCL1A [activation] ATM MDM4 [activation] GNAI2 OPRD1 [activation] CEBPA EP300 [activation] PRKCE SRC [activation] CSF2 CSF2RA [activation] NOS2 SRC [activation] CAPN1 CDK5R1 [activation] MPL THPO [activation] EP300 SIRT1 [activation] RIPK2 TRAF6 [activation] ARHGEF2 RHOA [activation] KRAS RALGDS [activation] NLGN1 NRXN2 [activation] LCK PTK2 [activation] PRIM2 RPA2 [activation] 页 4 共 20


CCND3 C1S CASP7 RASGRF1 CSF2 IRS2 PLCB1 ACACB CD3E CD36 PRKCA ATM ARF1 F2 HDAC1 ITGB3 NGFR ACVR1B PARD6A RBL1 ACTB EPOR IRAK1 BAIAP2 GJA1 BRAF CCR5 FGF4 NRAS MAP3K7 SETDB1 DUSP10 AKT1 C3 MAPK3 HSPB1 GZMA CD4 MAP3K1 CDK4 MAPK14 AR CASP7 KDR GNAI2 IL2 HDAC1 IL2RG ARF6 F2 CDK6 FGF3 ERBB4 CDK1 ANAPC10 CD14 C2 CDC42 FER F11 NFKBIA GNAI2 DAPP1 MLLT4 GRB2 IKBKG EZR RBL1 MAPK8 AKT1 CSK PARD6B IL7R CD44 RCHY1 DOK1

2016/4/8 19:13

RBL2 [inhibition] SERPING1 [inhibition] DFFA [activation] RRAS2 [activation] IL3RA [activation] JAK2 [activation] PRKCA [activation] PRKAA2 [inhibition] PIK3R1 [activation] THBS1 [activation] RARA [activation] FANCD2 [activation] ARFGAP1 [activation] F2RL3 [activation] RBPJ [inhibition] SRC [activation] NTRK2 [activation;inhibition] INHBA [activation] RAC1 [activation] SP1 [activation] ARPC1B [activation] GAB1 [activation] TAB1 [activation;inhibition] RAC1 [activation] MAPK7 [inhibition] MRAS [activation] GNAI2 [activation] FGFR2 [activation] RASGRP2 [activation] MAP4K1 [activation] SUV39H1 [activation] MAPK3 [inhibition] NR4A1 [inhibition] CR1 [activation] PRKCZ [activation] MAPKAPK2 [activation] SET [activation] HLA-DQA2 [activation] MAPK9 [activation] PRMT5 [activation] NCF1 [activation] KAT2B [activation] VIM [activation] PTPN11 [activation] IGF1R [activation] IL2RG [activation] JUN [activation] STAT5A [activation] PLD1 [activation] PROS1 [activation;inhibition] PCNA [inhibition] FGFR2 [activation] ITCH [activation] GORASP1 [activation] ANAPC11 [activation] IRAK3 [inhibition] C5 [activation] PRKCZ [activation] JUP [activation;inhibition] SERPINA5 [inhibition] SRC [activation] P2RY12 [activation] LCK [activation] RAP1A [activation] NGFR [activation] TRAF6 [activation] ROCK1 [activation] TFDP1 [inhibition] RAF1 [activation] MTCP1 [activation] PTPRC [activation] RAC1 [activation] TSLP [activation] COL1A2 [activation] TP73 [activation;inhibition] FYN [activation] 页 5 共 20


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IL1RAP IRAK1 [activation;inhibition] ROBO1 SRGAP2 [activation] CDK1 TP73 [activation;inhibition] PDGFRB PIK3CA [activation] FANCD2 USP1 [activation] TNF TNFRSF1A [activation] PLAU PLG [activation] NGFR NTRK1 [activation] CEBPB NFKB1 [activation] MAPK1 RPS6KA4 [activation] INSR PTPN2 [activation] EPHA2 GRB2 [activation] KAT2A RBPJ [activation] MAPK8 RAC1 [activation] RAB5A USP6NL [activation] ERBB3 PIK3R3 [activation] ATM MDC1 [activation] IL12B IL12RB2 [activation] NTRK2 SH2B2 [activation] PAK4 RAC1 [activation] IKBKB PEBP1 [inhibition] CAMK2G GRIA1 [activation] CD8A HLA-G [activation] GNAI3 RGS20 [activation;inhibition] IQGAP3 RAC1 [activation] LYN PLCG1 [activation] PARD3 PVRL1 [activation] CSK FGR [activation] PTK2 SYK [activation] ABL1 EPHB2 [activation] PORCN WNT4 [activation] CASP8 IKBKG [activation] ELMO1 RHOG [activation] PLXNB1 SEMA4B [activation] SFRP2 WNT1 [activation;inhibition] ITK LAT [activation] APC ARHGEF4 [activation] TNFRSF11A TNFSF11 [activation] ARRB2 CSNK1A1L [inhibition] MAP3K7 SMAD7 [activation] MAPK13 MAPT [activation] GNAQ HTR2A [activation] NGF PLG [activation] PTPN6 VAV1 [activation;inhibition] CDC42 RAC1 [activation] PDPK1 SGK2 [activation] HRAS RASSF5 [activation] ADCYAP1 ADCYAP1R1 [activation] GJA1 MAPK1 [inhibition] BRAF RAP1A [activation] CTTN FER [activation;inhibition] MAPK14 SHC1 [activation] PLCB3 PRKG1 [inhibition] CASP6 TOP1 [activation] PDGFRB PTK2 [activation] BCL2L11 MAPK9 [activation] JAK3 STAM [activation] DAPP1 LYN [activation] CDK7 RARA [activation] FGF6 FGFR3 [activation] TGFB3 TGFBR1 [activation] EPOR STAT5B [activation] DCLRE1C TP53BP1 [activation] TICAM1 TICAM2 [activation] MS4A2 PTPN11 [activation] GNAI1 IGF1R [activation] ACTN1 PTK2 [activation] LRP6 WNT1 [activation;inhibition] CDC42 WAS [activation] CDH1 GNA12 [activation] PRKG1 RGS2 [activation;inhibition] LYN RASA1 [activation] EGF GRB2 [activation] IL2RB JAK3 [inhibition] LCK STAT5A [activation] HRAS TIAM1 [activation] 页 6 共 20


RAP1A RAPGEF6 RAC1 TLR2 MAP2K1 PAK1 HCST PIK3R1 PIK3AP1 PIK3R1 IL12B IL12RB1 JAK2 STAM LYN PTPRC IRF3 TICAM1 CHRM1 GNAI2 IL23R STAT3 EFNB2 EPHB6 CAMK2D STAT1 LYN SPHK1 RAC1 WAS FGFR1 GRB2 RB1 TFDP2 MTOR RPS6KB2 MTOR RPTOR CD3E PIK3R2 CDC42 DOCK7 GABBR1 GNAO1 RBL1 TFDP2 PTK2 RET GAB1 MAPK1 AKT1 PTEN IKBKG RIPK1 PML TGFBR1 CD28 CD4 ACVR1C INHBB PRKCA RHOA CD8A LAT NFKB1 RIPK1 ERO1L P4HB PORCN WNT1 CREBBP SMAD4 LIPE PRKACA EFNB1 EPHB1 NOTCH1 PSEN2 MLST8 RPTOR NRAS PIK3CA HIST1H4A ITGB4 PTK2 HDAC1 NOTCH1 ACACA PRKAA2 CXCR5 GNAI2 IRAK1 IRAK4 MAPK1 PRKCZ BUB1B CDC20 GH2 GHR CASP3 LMNB1 CASP8 RIPK2 EZR SDC2 PF4 THBD CCL28 CCR10 EIF2B5 EIF2S2 SMURF1 TGFBR1 CHN2 RAC1 CSF1R PIK3R2 PPP2CB PRKCB PLCB1 PRKCD CTTN DNM2 CCND1 PRMT5 LIMK1 PAK4 PTPN6 SYK CALM1 EGFR ATR CHEK2 ILK PARVA CD8A HLA-B CXCR2 GNAI3 AKT1 PFKFB2 HLA-C KIR2DL2 AR SRY ELK1 FOS IGF1R PRKD1 ERBB3 PIK3CA

2016/4/8 19:13 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation;inhibition] [activation] [activation] [activation;inhibition] [inhibition] [activation;inhibition] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] RB1 [activation;inhibition] [activation] [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation;inhibition] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 7 共 20


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EFNA3 EPHA2 [activation] EGFR GSN [activation] CRK EGFR [activation] E2F1 PRMT5 [activation] PIK3R1 TYK2 [activation] CRK PXN [activation] ILK PPP1R12A [activation] CIITA NFYB [activation] SNCA TOR1A [inhibition] RIPK1 TRADD [activation] FGFR1 PIK3R1 [activation] CHRM2 GNG2 [activation] JAK2 PTK2 [activation] RDX ROCK1 [activation] DUSP10 MAPK9 [inhibition] GNAI1 MTNR1A [activation] F10 F3 [activation] CXCL16 CXCR6 [activation] CHUK MAVS [activation] CHEK2 RAD50 [activation] FOXP3 NFATC2 [activation] PRKCD SDC4 [activation;inhibition] GNAI1 RGS7 [activation;inhibition] EDA EDA2R [activation] DUSP19 MAPK9 [inhibition] MAPK3 STAT3 [activation] HLA-A KIR3DL2 [activation] BDKRB2 GNA11 [activation] MAPK8 RET [activation] IL2RB PIK3R1 [activation] CALM1 JAK2 [activation] GSK3B TSC2 [activation;inhibition] IFNGR1 SOCS1 [inhibition] TNFRSF12A TNFSF12 [activation] CDC42 PLD1 [activation] ADCY6 GNAS [activation] ATF1 RPS6KA5 [activation] ITK LCK [activation] CALM1 MYLK [activation] CXCL3 CXCR1 [activation] IL1A IL1RAP [activation] ACTA1 RAC1 [activation] KALRN RAC1 [activation] PRKACA RASGRF1 [activation] ADRB2 GNAS [activation] CCL2 CCR10 [activation] GHR PTPN6 [activation;inhibition] CBL EPHA2 [activation] ITGB3 PXN [activation] NFKB1 PRKACA [activation] FES PLXNA1 [activation] EFNB2 EPHB1 [activation] FGF17 FGFR1 [activation] AKT1 ILK [activation] FYN SNCA [activation] FLT1 GRB2 [activation] CHUK MAP3K14 [activation] FZD6 WNT4 [activation] EZR FAS [activation] ACTR2 WASF1 [activation] PDPK1 RALGDS [activation] ASIP MC1R [inhibition] LIF LIFR [activation] DUSP10 MAPK11 [inhibition] GNRH1 GNRHR [activation] IL2RB PTPN6 [activation;inhibition] CDC42 FGD1 [activation] ADAM17 ERBB4 [activation] CSNK1D CTNNB1 [activation] ACVR2B SMAD2 [activation] EEF2K PRKAA2 [activation] CASP6 LMNB1 [activation] PIK3R1 RRAS [activation] PDGFRB STAT5B [activation] KRAS PIK3CG [activation] HRAS RGL1 [activation] 页 8 共 20


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CASP8 TRAF2 [activation] CXCL2 CXCR1 [activation] KLRK1 MICB [activation] PPP2R1B RELA [activation] NOTCH3 PSEN1 [activation] FADD MAPK8 [activation] KSR1 RAF1 [activation] CASP10 CASP3 [activation] CALM1 PDE1A [activation] RYR2 SRI [activation] CREB1 CREM [inhibition] BTC EGFR [activation] CCL4 CCR8 [activation] AKT1 STAT1 [activation] ADAM17 NOTCH1 [activation] DUSP16 MAPK11 [inhibition] CTSG SERPINB13 [inhibition] INHA INHBB [activation] FGB SERPINA5 [inhibition] CSF2RB PTPN6 [activation;inhibition] JAK3 PIK3R1 [activation] CCL14 CCR1 [activation] DVL2 FZD4 [activation] ARF1 PIP5K1A [activation] LAT SYK [activation] DHH PTCH1 [activation] CASP8 CRADD [activation] SMAD1 SMAD3 [activation] NUP50 RAN [activation] FGF18 FGFR1 [activation] PDGFD PDGFRB [activation] FLT3 PIK3R1 [activation] GNAQ TSHR [activation] CXCR4 STAT2 [activation] ANAPC11 CDC27 [activation] MAP2K1 MAPK14 [activation] PRKACA RAP1A [activation] APP CASP8 [activation] CD47 THBS1 [activation] CSNK1E DVL3 [activation] CD44 VAV2 [activation] STX1A VAMP2 [activation] MAP3K14 TRAF6 [activation] FGF7 FGFR1 [activation] ARHGDIB RHOA [activation] IRS4 PIK3CA [activation] NCF1 RAC1 [activation] HLA-B KLRD1 [activation] KPNA1 NUP62 [activation] EFNA4 EPHA8 [activation] EP300 PML [activation] NCK2 WAS [activation] GAB1 PIK3CG [activation] CTNNA1 TJP1 [activation] NTRK1 RASGRF1 [activation] TNF TNFRSF1B [activation] GNAI1 OPRM1 [activation] FGFR1 PIK3R2 [activation] PIK3AP1 SYK [activation] FURIN NOTCH1 [activation] RIMS1 SNAP25 [activation] EIF2B3 EIF2S1 [activation] C3 ITGAM [activation] EIF4EBP1 RPS6KA5 [activation] IL13RA2 IL4 [activation] OSBP VAPB [activation] CD247 FYN [activation] CTNNB1 PTPN6 [activation;inhibition] CHRM3 GNAQ [activation] BID CASP10 [activation] CREB3L1 CREM [inhibition] AKT1 NR3C1 [activation] EPHB2 RASA1 [activation] IL1B IL1R2 [activation] RASSF5 RRAS [activation] GPC3 IGF2 [activation] 页 9 共 20


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AKT1 BRCA1 [activation] DOK1 SHC1 [activation] AR CASP8 [activation] ATR MCM2 [activation] APBB1IP RAP1A [activation] CSF1R PIK3R1 [activation] PRKCA SRC [activation] EPHB2 SRC [activation] ARF1 ASAP2 [activation] HRAS INSR [activation] MMP9 TIMP3 [inhibition] EFNA3 EPHA5 [activation] MAP3K11 RAC1 [activation] ITGB4 PRKCA [activation] ATM MRE11A [activation] MYC TP73 [activation;inhibition] ARF6 PIP5K1A [activation] AVPR2 GNAS [activation] GRB2 INPP5D [activation] MAGED1 NGFR [activation] DOK1 RASA1 [activation] PRKCI RHOQ [activation] CCL23 CCR1 [activation] HDAC3 RXRA [inhibition] AURKA GSK3B [activation] CDC16 FZR1 [activation] HIF1A NAA10 [activation] SRC TIAM1 [activation] GHR PTPN11 [activation] LCK NFKBIA [activation;inhibition] IFNAR1 PTPN6 [activation;inhibition] KCNJ1 SGK1 [activation] JUN STAT4 [activation] FGF9 FGFR4 [activation] CFLAR TNFRSF10A [inhibition] ATP2B1 PRKACA [activation] ARF1 CYTH1 [activation] RAF1 RRAS2 [activation] MAPKAPK2 TH [activation] LAT LCP2 [activation] LAT PLCG2 [activation] IL1R1 IRAK1 [activation;inhibition] GNAQ HTR2C [activation] ERBB4 NRG3 [activation] GAB2 SYK [activation] RIN1 RRAS2 [activation] CREB1 GSK3B [inhibition] PTPN6 SH3BP2 [activation;inhibition] GAB2 PIK3R1 [activation] CXCR1 GNAI2 [activation] DDX54 ESR2 [activation] ACTG1 WASF1 [activation] ADRA1B GNAQ [activation] TGFBR1 ZFYVE9 [activation] SHC1 SYK [activation] EFNA1 EPHA1 [activation] GNAS TSHR [activation] ANAPC11 FZR1 [activation] GNAO1 GRM6 [activation] FYB FYN [activation] ADRA1B GNA11 [activation] ARRB2 DVL2 [activation] EFNA2 EPHA2 [activation] LCK SHC1 [activation] CYFIP1 EIF4E [inhibition] ATF1 RPS6KA4 [activation] LFNG NOTCH2 [activation] BIRC2 MAP3K14 [activation;inhibition] CACNB2 PRKACA [activation] EGFR MAPK1 [activation] MAPK11 MAPKAPK5 [activation] ARHGEF6 RAC1 [activation] MAPK10 RELA [activation] PIK3R1 TLR3 [activation] ADAM17 TNF [activation] CD19 PIK3R1 [activation] 页 10 共 20


2016/4/8 19:13

ANAPC1 ANAPC7 [activation] HTT RAC1 [activation] CASP3 SLK [activation] XCL2 XCR1 [activation] KRAS RAF1 [activation] IGF1R PRKCD [activation] ARRB2 CXCR4 [activation] PARK2 SNCA [activation] CTF1 IL6ST [activation] CBL PTPN11 [activation;inhibition] CAPN2 CDK5R1 [activation] BCL2 CYCS [inhibition] NTRK1 SH2B1 [activation] APP MAPK13 [activation] ESR1 SMAD3 [activation] AKT1 RAC1 [activation] KRAS RASGRP2 [activation] STAT5A TEK [activation] PIK3R1 TEK [activation] AR SRC [activation] PAK1 RAC1 [activation] IGF1R IRS4 [activation] RAC1 TRIO [activation] CCL26 CCR1 [activation] TNFRSF11B TNFSF10 [activation] ARHGAP17 RAC1 [activation] ELK1 SRF [activation] CASP2 CASP7 [activation] KRIT1 RAP1A [activation] CDC42 WASF2 [activation] C2 C3 [activation;inhibition] CRK PDGFRB [activation] CHEK2 FOXM1 [activation] MAPK14 MAPK8 [activation] PTK2 RAC1 [activation] AR NR2C2 [activation] F2 F9 [activation] LAT PTPN1 [activation] CASP1 IL33 [activation] RAPGEF4 RRAS2 [activation] EPHA2 SHC1 [activation] INHA INHBA [activation] KIR2DL3 PTPN6 [activation;inhibition] EP300 SKP2 [activation] ELK1 MAPK9 [activation] AMOT WWTR1 [activation] MAP3K14 RIPK1 [activation] EXOC2 RALA [activation] CXCR4 STAT5B [activation] HRAS RASGRP4 [activation] CDC25A CDK1 [activation] NTRK1 PTPRC [activation] IL2RA STAT5B [activation] GNAI2 TBXA2R [activation;inhibition] IKBKB PRKCZ [activation] FFAR1 GNAQ [activation] AKT1 GRB10 [activation] CCL7 CCR10 [activation] LAT PLCG1 [activation] NCK1 PTK2 [activation] BMP6 BMPR1B [activation] CCL28 CCR3 [activation] TGFB1 TGFBR1 [activation] HLA-E KLRC1 [activation] CASP9 DIABLO [activation] EIF2B1 EIF2S2 [activation] ADCY3 CAMK2G [inhibition] PRKCH SRC [activation] CCL16 CCR5 [activation] AURKB CENPA [activation] HIST1H3A TAF1B [activation] CHUK TNFRSF1A [activation] IKBKB MAVS [activation] NOTCH4 PSEN1 [activation] RIPK1 TNF [activation] CDC42 IQGAP2 [activation;inhibition] 页 11 共 20


NRP1 SEMA3C GNAI1 GNB1 EFNA4 EPHA5 DOCK1 RAC1 CAB39 PRKAA1 DOCK2 RAC1 GRB2 LAT FGF8 FGFR4 LRP8 RELN CAV1 IRS1 BTK PLCG1 CD79A PTPRC RAP1A RAPGEF5 AKT2 TSC2 ARNTL PER3 KDR SH2D2A ESR1 MAPK14 GJA1 MAPK3 BIRC5 CASP9 MAP3K7 MAPK14 FCGR2A LAT BCAR1 PTPN1 HSPG2 ITGA2 ACTB PFN2 JAK3 PTPN6 PEBP1 PRKCZ IL12RB1 STAT4 LEPR STAT3 PRIM2 RPA1 LYN MS4A2 CXCR4 STAT1 JUP SRC MAPK14 MEF2C CD244 SH2D1B NOTCH3 PSEN2 ARHGEF12 CRTC2 YWHAZ CTNND1 CTTN STX1A UNC13B EFNA3 EPHA4 HLA-G KLRD1 HLA-E KLRD1 APOA5 LPL NCK1 PAK3 ACVR1 INHBC AKT1 AKT2 IRF7 MAVS RAN RCC1 CCNA2 TP73 ANAPC11 PTTG1 PLD1 RHOA CEBPA CREBBP MAP2K3 TAOK1 CD28 LCK IRS1 PIK3CB GNA11 HTR2A ERBB4 HBEGF ADCY7 PRKCD PLCB1 RGS4 PDE3B PRKACA IL1B IL1RAP IL2RA STAT3 IL1A IL1R1 CDC42BPA ACVR2B INHBC GNAI2 OPRM1 LFNG NOTCH1 PRKCI SRC ARHGEF11 MFNG NOTCH2 TIRAP TRAF6 FYN PLCG1 ATR BRCA1 RHOA VAV2 E2F1 E2F6 CHUK PRKCQ

2016/4/8 19:13 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation;inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] CD44 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] MYL2 [activation] [activation] [activation] [activation] [activation] GNA13 [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] 页 12 共 20


CCL11 AKT1 GNAI3 IL6ST CDC20 DVL2 NFATC1 CREBBP LYN PLCB2 IKBKG L1CAM NCOR2 ACTR2 STAT5B CCR5 IL4R CHN1 TNF IL12RB1 PLXNB3 BRCA1 ACVR1B MAPK1 EIF2B4 CBL CYBB TNF MAPK1 INSR BCL10 IKBKB MAPK14 ETV1 LIMK1 IL6ST CTSG CSNK1G1 PRNP AMOT IFNA1 CCL3L1 MCM7 GNAI1 SELE F2R AKT1 CDK5R1 BRK1 CSK ACTB NOTCH4 MAP2K4 ITGA2B CD79A RAC1 RAP1B DTX1 CRK ANAPC1 MAPK8 RANBP1 ESR2 STAT2 AR RALGDS CD3E PDC CCL14 CEBPB BMP5 AKAP13 MAGI2 ARF6 CREB1 MAPK11

2016/4/8 19:13

CCR2 [activation] PIK3R1 [activation] HTR1A [activation] PTPN6 [activation;inhibition] MAD2L1 [inhibition] RAC1 [activation] PIM1 [activation] MYB [activation] PLCG2 [activation] RAC1 [activation] RELA [activation] NRP1 [activation] RXRA [inhibition] WASF2 [activation] TEK [activation] GNAI1 [activation] PTPN6 [activation;inhibition] RAC1 [activation] TNFAIP3 [activation] IL23A [activation] SEMA4A [activation] NBN [activation] SMAD2 [activation] MKNK2 [activation] EIF2S2 [activation] EGFR [activation] RAC1 [activation] TRAF2 [activation] MAPK8 [activation] SOCS2 [inhibition] CHUK [activation] MAP3K14 [activation] PPARGC1A [activation] MAPKAPK2 [activation] PAK1 [activation] PIK3CG [activation] F2R [activation] FOXO1 [activation] STIP1 [activation] YAP1 [activation] IFNAR1 [activation] CCR3 [activation] RAD17 [activation] MTNR1B [activation] SELPLG [activation] GNAI2 [activation] S1PR1 [activation] PAK1 [activation] RAC1 [activation] LCK [activation;inhibition] WASF2 [activation] PSEN2 [activation] MAP3K7 [activation] TLN1 [activation] PTPN6 [activation;inhibition] WASF1 [activation] RASSF5 [activation] NOTCH2 [activation] MAPK8 [activation] CDC27 [activation] NR3C1 [activation] XPO1 [activation] MAPK11 [activation] TYK2 [activation] MDM2 [activation] RRAS2 [activation] LAT [activation] PRKACA [activation] CCR3 [activation] MAPK3 [activation] NOG [inhibition] GNA12 [activation] PTEN [activation] ASAP2 [activation] MAPK14 [activation] RPS6KA5 [activation] 页 13 共 20


CSNK1D CTLA4 SP1 CD244 SST ELK4 F12 CASP3 NUP50 CTNND1 PLCG2 GNAI2 FYN SRC FGF18 PRKACA ROBO1 GNAI2 CASP3 FGF6 SNAP23 JAK2 CRHR1 CDH1 NOTCH2 PDPK1 GNA11 ARAF C1R PRKCE NRP1 PIK3R1 FGR IGF1R FGF17 GNAI1 FZD5 AKT1 NCOR1 ADIPOQ GNAQ APBB1IP RAP1A LRP5 IFNAR1 AKT1 ANAPC4 ARPC3 PTPN11 CASP6 MAPK1 CBLB E4F1 NUP153 PML CACNG2 E2F4 ITGB1 APC GRB2 SHC1 LCP2 IRS2 ATF1 EEF2K CD19 ADRBK1 FCGR2A GNAS HES1 CD44 ACTB EFNA5 EFNA1 IKBKG ARHGEF6

2016/4/8 19:13

PER3 [activation;inhibition] PTPN11 [activation] SP3 [activation] LAT [activation] SSTR2 [activation] MAPK11 [activation] KLKB1 [activation] RFC1 [activation] XPO1 [activation] PTPN6 [activation;inhibition] TEC [activation] MTNR1B [activation] PTPRC [activation] STAT5A [activation] FGFR4 [activation] STK11 [activation] SLIT1 [activation] RASD1 [activation] TOP1 [activation] FGFR4 [activation] VAMP1 [activation] TEC [activation] GNAI1 [activation] GNA13 [activation] PSEN2 [activation] RPS6KB2 [activation] HTR2B [activation] RRAS [activation] SERPING1 [inhibition] SLC25A4 [inhibition] SEMA3F [activation] PTPN6 [activation;inhibition] SNCA [activation] INS [activation] FGFR4 [activation] RGS20 [activation;inhibition] WNT7A [activation] CREB1 [activation] PPARA [inhibition] ADIPOR2 [activation] HTR2B [activation] PFN1 [activation] RASGRP2 [activation] WNT1 [activation;inhibition] IFNW1 [activation] PRKCB [activation] FZR1 [activation] WASF2 [activation] SOCS1 [inhibition] SATB1 [activation] MITF [activation] SPRY2 [inhibition] TP53 [activation] SMAD2 [activation] TGFBR2 [inhibition] PRKACA [activation] SMAD2 [activation;inhibition] SPP1 [activation] PPP2R5A [activation] SHC3 [activation] SRC [activation] PIK3R1 [activation] PTPRF [inhibition] PRKACA [activation] RPS6KB1 [activation] CD79B [activation] CCR5 [activation] HCK [activation] PTGIR [activation] STAT3 [activation] COL1A1 [activation] EZR [activation] EPHA8 [activation] EPHA6 [activation] TNF [activation] PARVB [activation] 页 14 共 20


2016/4/8 19:13

HHIP IHH [inhibition] JAM3 PARD3 [activation] BTC ERBB4 [activation] CHEK1 RAD51 [activation] CASP6 LMNA [activation] NCK1 RAC1 [activation] TSHB TSHR [activation] CTNNB1 HNF1A [activation] ESR1 NCOA1 [activation] ABL1 CDK5 [activation] CDC42 RAC2 [activation] ADCY5 PRKCA [activation] SNCA SYK [activation] FRS2 SOS1 [activation] CTBP1 EP300 [activation] MRAS RAF1 [activation] F2R GNA12 [activation] MKNK1 PLA2G4A [activation] HGS MET [activation] C4B C4BPA [inhibition] ADRB2 GNAI2 [activation] DAB1 LRP8 [activation] CD44 TIAM1 [activation] BRCA1 CHEK2 [activation] PRKCI RAC1 [activation] CXCL6 CXCR2 [activation] LCK PTPN11 [activation;inhibition] GRB2 TEK [activation] CCL26 CCR3 [activation] MAPK1 NOTCH1 [activation] MAPK9 SMAD3 [activation] MAPT MARK2 [activation] F13A1 FGG [activation] CDK2 FOXM1 [activation] RAC1 STAT3 [activation] SRPK1 SRSF8 [activation] ATM RAD9A [activation] CAV1 PRKACA [activation] TNFRSF17 TNFSF13 [activation] AGAP2 PIK3R1 [activation] GNB1 KCNJ3 [activation] EP300 SMAD3 [activation] CBL INSR [activation] CD19 LYN [activation] PTN SDC3 [activation] MDM2 RANBP2 [activation] MAPK14 STAT1 [activation] PTPN2 SHC1 [activation] AKT1 PDE3B [activation] FGA SERPINA5 [inhibition] CHUK PRKCI [activation] NLGN3 NRXN3 [activation] EPOR PTPN6 [activation;inhibition] BCR RAC1 [activation] GRK5 SNCA [activation] HRAS PLCE1 [activation] MAPK3 MYC [activation] HIST1H4A TAF1B [activation] FGF17 FGFR3 [activation] DNM2 KDR [activation] EGFR PTPN6 [activation;inhibition] ATF2 JDP2 [activation] PORCN WNT3A [activation] CEBPB RELA [activation] EP400 TP53 [activation] ESR1 SMAD4 [activation] CHEK2 PLK3 [activation] F2 PLAU [activation] GSK3B JUN [activation] ATM BRCA1 [activation] KLC1 SPAG9 [inhibition] FCGR1A HCK [activation] MAP2K6 MAP3K7 [activation] MYB SKI [activation] DUSP7 MAPK8 [inhibition] HSP90AA1 PTK2 [activation] 页 15 共 20


ATM CDC25B CAMK4 HRAS CREM ACVR1B DUSP16 CEBPD DVL1 CSNK1A1 ADAM10 MAP3K14 CALM1 ADRBK2 KDR MYC FZD9 EFNB2 DPYSL2 CSK F2R RAPGEF1 FGFR2 SMAD4 DLL4 E2F1 PRKCA EFNA1 ARF6 HCK KIT PLD1 ACTB CREB1 FRS2 IRAK1 FLT3 PIK3CA ANAPC1 ACVR1 AVP MAP3K14 PLXNA1 ATF2 ARHGEF4 ARAF RAD51 PFKFB2 CTNND1 IKBKG ARHGEF3 CD226 ERBB4 EPHB2 IRF7 EP300 DRD2 FANCC ETS1 LSP1 CAV1 ATF4 NOTCH3 MAPK3 ANAPC11 KRAS MLLT4 PIK3R1 ESR1 EEF2K F2 JAK1 KLK6 JUND AKT2 CAMK2A

2016/4/8 19:13

SMC1A [activation] MAPKAPK2 [activation] CAMKK1 [activation] VAV1 [activation] PRKACA [activation] SMAD3 [activation] MAPK9 [inhibition] RELA [activation] RAC1 [activation] TP53 [activation] DLL1 [activation] MAPK3 [activation;inhibition] ITPKA [activation] OPRM1 [activation] PLCG2 [activation] NFYC [activation] WNT7A [activation;inhibition] EPHB2 [activation] GSK3B [activation] HCK [activation] PLG [activation] RHOQ [activation] PIK3R1 [activation] TGFBR2 [activation] NOTCH1 [activation] TP53 [activation] RAF1 [activation] EPHA7 [activation] ASAP3 [activation] PIK3R1 [activation] STAT5A [activation] PRKCA [activation] WASF1 [activation] RPS6KA4 [activation] SRC [activation] PPP2CA [inhibition] FLT3LG [activation] PRKCD [activation] CDC20 [activation] INHBB [activation] AVPR2 [activation] TRAF3 [activation] RND1 [activation] MAPK1 [activation] RAC1 [activation] RRAS2 [activation] RAD51C [activation] PRKAA2 [activation] PTPRM [activation] MYD88 [activation] RHOA [activation] PVR [activation] YAP1 [activation] RRAS [activation] TICAM1 [activation] MYB [activation] GNAI2 [activation] FANCD2 [activation] MAPK3 [activation] MAPKAPK2 [activation] FYN [activation] EP300 [activation] RBPJ [activation] MAPK8 [activation] ANAPC2 [activation] PIK3R2 [activation] RRAS [activation] PLCG1 [activation] MAPK3 [activation] PRKAA1 [activation] SERPINC1 [inhibition] PIK3R1 [activation] SNCA [activation] MAPK8 [activation] MTCP1 [activation] NOS1 [activation] 页 16 共 20


2016/4/8 19:13

IKBKB IRAK1 [activation;inhibition] IL1RAP TRAF6 [activation] CNR1 GNAI1 [activation] IL6ST LIF [activation] SMPD3 TNF [activation] PAK3 RAC1 [activation] CCR2 JAK2 [activation] ADCY5 PRKACA [activation] ANGPT1 ANGPT2 [inhibition] CLOCK PER3 [activation;inhibition] MAP2K6 MAPK13 [activation] F2 F2RL2 [activation] FRS2 MAPK1 [activation] ARHGEF7 RAC1 [activation] NOTCH2 PSEN1 [activation] NTRK1 SHC2 [activation] F2 PROC [activation;inhibition] CSK PAG1 [activation] HRAS MLLT4 [activation] NOS1 PRKCA [activation] JAK1 PRKCZ [activation] XCL1 XCR1 [activation] DNAJB1 DNAJC3 [inhibition] FGF1 FGFR4 [activation] CHRM2 GNA14 [activation] PIK3R1 RET [activation] BMP5 BMPR1A [activation] PIK3R1 RAC1 [activation] IRS2 PIK3R2 [activation] ADRB2 ARRB1 [activation] PAG1 PTPN11 [activation] GNAI3 LPAR1 [activation] HIST2H3A TAF1B [activation] SFRP1 WNT1 [activation;inhibition] IRS1 MAPK1 [activation] KIT SH2B2 [activation] ITGB2 PTK2 [activation] CCND1 RBL2 [inhibition] CACNA1C PRKACA [activation] NLGN3 NRXN2 [activation] ADCY5 GNAS [activation] CDK1 CSNK2B [activation] ANAPC1 CDC23 [activation] ERBB4 NRG4 [activation] PROC THBD [activation] GNB1 MTNR1A [activation] DDX58 TBK1 [activation] CASP6 KRT18 [activation] ATM KAT5 [activation] MAP2K6 TRAF6 [activation] PDGFRB PTPN2 [activation] CREB1 MAPKAPK2 [activation] AKT2 CHUK [activation] IKBKG IRAK4 [activation] TNFRSF13B TNFSF13 [activation] ATM CHEK2 [activation] NOD1 SUGT1 [activation] ACTB PRKCD [activation] RAC1 VAV1 [activation] ACVR2A INHBC [activation] OPHN1 RHOA [activation] TGFBR2 ZFYVE9 [activation] GRB2 MS4A2 [activation] EPHB2 SYNJ1 [activation] LIMK2 ROCK1 [activation] ITGB1 PTK2 [activation] FGF3 FGFR3 [activation] PPP2CA RPS6KB1 [activation] DNAJC3 EIF2AK2 [inhibition] IL13 IL13RA2 [activation] KSR1 MAPK1 [activation] EGFR MAP2K2 [activation] IKBKG PRKCQ [activation] MAPK1 NR3C1 [activation] FZD9 WNT1 [activation;inhibition] GRIA3 LYN [activation] 页 17 共 20


OSM OSMR MAP4K5 TRAF2 ARHGEF12 GAS1 SHH CHEK2 MDC1 CTNNB1 PTPN1 ACVRL1 BAMBI CTSG F2RL1 MMP7 NGF HLA-C KIR2DS2 FZD1 WNT2 PORCN WNT7B LAT LCK LCP2 VAV3 CDK2 TP73 CSNK1D DVL3 PRKG1 RAF1 FGF17 FGFR2 EDNRB GNA13 CXCR2 PPP2CA EP300 JDP2 NCOR1 RXRA ARHGEF25 CSF2RB STAT1 PPARA RXRA C3 C3AR1 APOC2 LPL EP300 HDAC1 CFLAR FAS CREB1 EP300 ECSIT TRAF6 NFATC2 PPP3R1 AKT1 CSF2RB MAPK1 SNAI1 ATF4 CREBBP CALM1 ITPKB CTNNB1 PTPRM EFNA4 EPHA2 GHR IRS1 IGF1R SRC E2F1 TFDP1 LCK STAT1 ANAPC10 FZR1 FARP2 SRC MAPK8 RB1 CHRM2 GNA11 IRAK1 TAB2 BIRC3 TNF CDK2 CDKN1C CASP3 VIM EXOC7 RHOQ ACVR1B INHBB MAPK8 TRAF6 BRCA1 CDK2 MAPK3 PXN GRB2 SHC4 RAPGEF3 RRAS2 ELK1 MAPK1 ACVR1B INHBC LCK PRKCD CALM1 KRAS ACTB RAC1 ELMO1 RAC1 HLA-C KIR2DS1 GSN PLCG1 PRKG1 VASP CASP6 CASP8 GPC3 WNT3A MAP2K3 MAPK12 CD28 PIK3CG FYN PLD2 IRAK1 MAP3K7 AKT1 GAB2 ANAPC10 ANAPC7 ASF1A TP53 EIF2AK2 NFKBIA

2016/4/8 19:13 [activation] [activation] GNA12 [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] RAC1 [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] 页 18 共 20


2016/4/8 19:13

F2 F2RL1 [activation] PRKACA VASP [activation] ANK1 ITPR3 [activation] IFNGR1 PTPN11 [activation;inhibition] AKT1 MST1R [activation] KPNA2 NUP153 [activation] DUSP16 MAPK1 [inhibition] CD247 CD28 [activation] DRD2 GNAI3 [activation] SIRT1 TP73 [activation;inhibition] MAPK8 SHC1 [activation] FZD8 WNT1 [activation] INSR PIK3R3 [activation] BACE1 PSEN1 [activation] E2F1 TFDP2 [inhibition] MYO5A RAB11A [activation] JAK2 PDGFRB [activation] GPC3 WNT7B [activation] NCK1 WAS [activation] DNAJC3 EIF2AK3 [inhibition] ERBB4 MDM2 [activation] FOXO3 YWHAG [inhibition] BIRC2 TRADD [activation] HLA-B KIR3DL1 [activation] EGFR EPN1 [activation] EFNA1 EPHA8 [activation] CTNNA1 MLLT4 [activation] NTRK3 SHC2 [activation] IRF5 TRAF6 [activation] EPHA2 RASA1 [activation] CFLAR FASLG [inhibition] CXCR4 GNAI1 [activation] CHUK IKBKG [activation] F2RL1 PLG [activation] NCF1 PRKCD [activation] INSR SH2B2 [activation] HDAC2 TP53 [activation] EIF4G1 EIF5 [activation] CD27 CD70 [activation] GNA12 TBXA2R [inhibition] FXYD1 PRKACA [activation] EIF2AK1 EIF2S1 [activation] ICOS ICOSLG [activation] MMP3 PLG [activation] PDPK1 SGK3 [activation] PTPN11 STAT3 [activation] CTNND1 SRC [activation] AKT1 HSP90AB1 [activation] GRB10 INSR [activation] TNFRSF11B TNFSF11 [activation] EIF3D EIF5 [activation] JUNB MAPK14 [activation] EFNA2 EPHA3 [activation] APBB1IP VASP [activation] LCP2 PLCG2 [activation] IQGAP2 RAC1 [activation] CTNNB1 TGFBR1 [activation] EIF4B RPS6KB1 [activation] JUN MAPK11 [activation] ICAM3 ITGB2 [activation] FLT4 PTK2 [activation] CRHR1 GNAO1 [activation] IKBKG PRKCI [activation] CD8A HLA-E [activation] PLCG1 VAV3 [activation] IL3 PIK3CA [activation] HRAS MAP2K1 [activation] TGFB2 TGFBR2 [activation] DCLRE1C MRE11A [activation] ERBB2 PIK3R1 [activation] ANAPC1 FZR1 [activation] BMX PTK2 [activation] CREB1 RPS6KA5 [activation] COL1A2 ITGA2B [activation] CHRM2 GNA15 [activation] JUN PPARG [activation] 页 19 共 20


2016/4/8 19:13

PFKFB2 PRKAA1 [activation] LTBR TNFSF14 [activation] PRKCA RAC1 [activation] ARHGEF11 GNA12 [activation] IRAK1 IRAK3 [activation;inhibition] ANAPC11 ANAPC4 [activation] PPP1R1B PRKACA [activation] CDC23 FZR1 [activation] HMGN1 RPS6KA5 [activation] FCER1G LYN [activation] CAMK4 CREBBP [activation] CDK5 FYN [activation] RB1 TFDP1 [inhibition] PIK3R1 THRB [activation] MAP3K7 TGFBR1 [activation] PRKACA RELA [activation] ADORA1 GNAI2 [activation;inhibition] CCL3L1 CCR1 [activation] KIR2DL1 PTPN6 [activation;inhibition] IRS1 PTPRF [inhibition] PAK6 RAC1 [activation] AKT1 HSP90AA1 [activation] AKT1 ESR1 [activation] CREBBP SMAD3 [activation] CAMKK1 PRKAA1 [activation] GNAO1 GPSM2 [inhibition] CDK2 POLA1 [activation] AR HDAC1 [activation] ARHGEF2 RAC1 [activation] LCP2 WAS [activation] RANBP2 XPO1 [activation] AKT1 YWHAZ [activation] LYN SNCA [activation] CD28 ITK [activation] FZD9 WNT2 [activation;inhibition] HRAS PDGFB [activation] MAP3K7 MAPK8 [activation] RAP1B RAPGEF1 [activation] DLL4 NOTCH4 [activation] MDM2 PIAS1 [activation] ADCY2 GNAS [activation] CDC42 PARD3 [activation] DOK1 NCK1 [activation] ERBB3 PIK3CB [activation] KPNA1 RANBP2 [activation] DOK1 LCK [activation] JAK2 STAT2 [activation] MAPK14 MITF [activation] MRAS PIK3CA [activation] ARHGEF1 CD44 [activation] EIF2B4 EIF2S1 [activation] HIF1A VHL [inhibition] CHEK2 TP53 [activation] ADAM12 EGF [activation] EDNRB GNA11 [activation] AURKA CDC25B [activation] RAC1 RAP1GDS1 [activation] CCL14 CCR5 [activation] CCNE1 RRN3 [activation] F10 TFPI [inhibition] IL2RB STAT5A [activation] MAPK14 TRAF6 [activation] EGFR MAP2K1 [activation] MAPK3 PTPN5 [inhibition] MYB TRIM28 [activation] DRD3 GNAI1 [activation] ANXA2 PLG [activation] GRB10 GRB2 [activation] GNB1 MTNR1B [activation] MYC NFYB [activation] ECT2 PLK1 [activation] DLL1 NOTCH3 [activation] FGFR1 SHC1 [activation] CYBA RAC1 [activation] NFKBIA TNF [activation] 页 20 共 20

KEGG validation 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76

2016/4/8 19:14

GNAI1 PIK3R5 [activation] GNA12 RASA2 [activation] OPRD1 GNAI1 [activation] CSF1R IRS1 [activation] TLR2 RAC1 [activation] MTOR PPARG [activation] RRAS2 TIAM1 [activation] AKT3 CDKN1B [inhibition] TNFSF14 LTBR [activation] TLR4 NFKB1 [activation] PRKD3 RAP1A [activation] JAK1 PIK3CA [activation] HRAS BRAP [activation] IL10 STAT3 [activation] TNFSF11 TNFRSF11A [activation] TNF IKBKB [activation] CNTF IL22RA2 [activation] IHH PTCH1 [activation] STK11 FOXO6 [activation] PRKD1 ITGAL [activation] ZAP70 LAT [activation] HTR7 GNB5 [activation] CALML6 MYLK4 [activation] RALBP1 ARF6 [activation] RAP1A MAP2K3 [activation] CSF2 IL22RA2 [activation] KDR PIK3R5 [activation] PRKACA SLC9A1 [activation] RAC1 MAPK8 [activation] SOS1 RRAS2 [activation] PLCG1 NOS3 [activation] WIF1 WNT16 [inhibition] MAPK1 SMAD4 [activation;inhibition] CD14 TLR4 [activation] CSNK2A1 NFKBIA [activation] CASP10 CASP7 [activation] RAC1 PAK1 [activation] CHRM1 GNAL [activation] PDPK1 PKN3 [activation] CAMK4 PDE3A [inhibition] FBXW11 GLI1 [inhibition] RASSF5 STK4 [activation] ERBB4 SHC2 [activation] SIPA1 RAP1A [activation] CDC42 ACTB [activation] STK11 PRKAG2 [activation] PRKACA FXYD1 [activation] ADORA2A GNAQ [activation] BTK PLCG2 [activation] TLN1 ITGA2B [activation] VASP ACTB [activation] EIF4EBP1 EIF4E [inhibition] RRAS PIK3R5 [activation] LCP2 RAP1A [activation] BAD BCL2 [inhibition] SIPA1L1 RAP1A [activation] RAC1 PRKCI [activation] RRAS2 RGL2 [activation] WNT16 LRP6 [activation] ERBB4 PIK3R5 [activation] WNT11 FZD10 [activation] MAP3K14 MAP3K7 [activation] CXXC4 DVL1 [inhibition] ADIPOQ ADIPOR1 [activation] RRAS2 PLCE1 [activation] RASGRP1 HRAS [activation] VAV3 RAC1 [activation] CHRM1 GNAI1 [activation] SIPA1L2 RAP1A [activation] PIK3AP1 PIK3CA [activation] RRAS2 RALBP1 [activation] CDK2 FOXO6 [activation;inhibition] PRKAG2 ACACA [activation;inhibition] PIK3R5 AKT3 [activation] RASGRF1 MRAS [activation] RASGRF1 RRAS2 [activation] 页 1 共 5

KEGG validation 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152

2016/4/8 19:14

TIAM1 RAC1 [activation] RRAS RALBP1 [activation] MLLT4 CTNND1 [activation] NTF3 NTRK1 [activation] RRAS2 RIN1 [activation] RIPK1 IKBKG [activation] PRKCA PRKD3 [activation] SFRP1 WNT16 [inhibition] RRAS2 MOS [activation] CSNK1E FOXO6 [activation;inhibition] WNT16 FZD10 [activation] TNF TNFRSF1A [activation] SOS1 MRAS [activation] STAT3 FOXO6 [activation] RAC1 PIK3CA [activation] RAP1A APBB1IP [activation] CASP3 MAP3K1 [activation] HRAS RASSF5 [activation] SOX17 LEF1 [inhibition] PDPK1 CHUK [activation] PRKG1 RGS2 [activation;inhibition] PRKACA PPP1R1B [activation] HRAS TIAM1 [activation] AKT3 FOXO3 [inhibition] DUSP3 MAPK8 [inhibition] MAPK1 PLA2G4B [activation] NF1 RRAS2 [activation] RAP1A BRAF [activation] MRAS PIK3R5 [activation] ADCYAP1R1 GNAS [activation] NPY CHRM1 [activation] NKD1 DVL1 [inhibition] PRKACA CREB3 [activation] RALA EXOC2 [activation] RASGRP3 RAP1A [activation] PIK3R5 RAC1 [activation] PRKCE KCNJ8 [activation] ADRA1D GNA13 [activation] GDF7 BMPR1A [activation] RAP1A PRKD1 [activation] HRAS PIK3R5 [activation] RRAS2 BRAP [inhibition] AKT3 NR4A1 [inhibition] PRKACA RASGRF1 [activation] MAPK1 CREB3 [activation] RAPGEF5 RAP1A [activation] RRAS2 RAF1 [activation] CASP10 CASP3 [activation] BTC EGFR [activation] ADAM17 NOTCH1 [activation] CASP3 PAK1 [activation] RALGDS RAC1 [activation] CALML6 RASGRF1 [activation] CUL1 SMAD2 [inhibition] GNAL ADCY1 [activation] RAP1A VAV3 [activation] PDPK1 AKT3 [activation] TRAF2 BTK [activation] RALBP1 RAC1 [activation] APBB1IP TLN1 [activation] ITPKA CALML6 [activation] MAPK1 FOXO6 [activation;inhibition] RHOA ACTB [activation] NLK FOXO6 [inhibition] TNFRSF1A CASP3 [activation] PRKACA ATP2B1 [activation] RALGDS RALA [activation] RAP1A ARAP3 [activation] PRKACA PPARA [activation] RASGRP1 RRAS2 [activation] LAT LCP2 [activation] IL1R1 IRAK1 [activation;inhibition] NOG GDF7 [activation;inhibition] GNAS ADCY1 [activation] KDR PTK2 [activation] SMAD2 BMPR1A [activation;inhibition] 页 2 共 5

KEGG validation 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228

RAP1A TRADD MAPK8 WNT5A CAMK2A CTNNB1 KDR MTCP1 PLCG1 PRKACA TGFBR2 LAT TGFB1 ERBB3 GAB1 RRAS2 PRKG1 AKT3 PRKG1 CAMKK2 SYK IL6R RAP1A PORCN RAC1 KDR DOCK4 RAP1A HBEGF ADORA1 AKT3 RASGRP2 ADRA1D RAPGEF3 CSF1R CDH1 ADORA2A RASGRF1 ARAP3 CSF1R IL1A LFNG CSF1R DDIT4 RAPGEF6 BAMBI HSPA1A DUSP3 SFRP1 RRAS2 MAPK1 BDNF FSHB IL6 PTPN6 STK3 KDR CASP8 MAPK1 NCK1 MYC SRC HHIP BTC CREBBP HDAC1 PLCG1 CSNK1E IL1R1 MAPK14 IL24 NOTCH1 RIPK1 RALA RASGRF1 PRKAG2

2016/4/8 19:14

PLCE1 [activation] MAP3K7 [activation] FOXO6 [activation] FZD10 [activation] CREBBP [activation] MAGI3 [activation] CDC42 [activation] AKT3 [activation] PRKCA [activation] SOX9 [activation] RHOA [activation] PLCG1 [activation] TGFBR1 [activation] PIK3R5 [activation] PIK3R5 [activation] BRAF [activation] BAD [activation;inhibition] CHUK [activation] CACNA1C [inhibition] PRKAG2 [activation] BTK [activation] STAT3 [activation] VAV2 [activation] WNT16 [activation] MAP3K1 [activation] SH2D2A [activation] RAP1A [activation] PIK3R5 [activation] ERBB4 [activation] GNAI1 [activation;inhibition] MDM2 [activation] RAP1A [activation] GNA11 [activation] RAP1A [activation] SHC2 [activation] RAPGEF1 [activation] GNAS [activation] HRAS [activation] RHOA [activation] PLCB1 [activation] IL1R1 [activation] NOTCH1 [activation] CRK [activation] TSC2 [activation;inhibition] RAP1A [activation] FZD10 [activation] MAPK8 [inhibition] MAPK14 [inhibition] FZD10 [inhibition] PIK3R5 [activation] ELK1 [activation] NTRK1 [activation] ADCYAP1R1 [activation] STAT3 [activation] IL22RA2 [activation;inhibition] LATS2 [activation] PXN [activation] CASP7 [activation] TSC2 [activation;inhibition] PAK4 [activation] CDKN2B [activation;inhibition] PIK3R5 [activation] IHH [inhibition] ERBB4 [activation] RBPJL [activation] RBPJL [inhibition] PPP3CA [activation] GSK3B [activation;inhibition] CASP3 [activation] CEBPB [activation] IL22RA2 [activation] RBPJL [activation] MAP2K3 [activation] MAPK8 [activation] RRAS [activation] GYS1 [inhibition] 页 3 共 5

KEGG validation 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304

PRKG1 RAC1 EGFR HRAS GNA13 RAPGEF2 GNAI1 DVL1 PRKCA RRAS2 RAP1A NRG3 RRAS2 DLL3 RAB23 AKT3 PDPK1 CNR1 RAC1 FOXO4 RHOA HRAS CAMK4 CYSLTR1 NCSTN AKT3 KRIT1 ARF6 TRAF2 RAP1A RAP1GAP NRG1 PRKAG2 RPS6KB1 MAPK1 VAV2 RAP1A PRKG1 PRKACA PLCG1 RAB10 RRAS2 GHRL PRKACA RGL1 RAPGEF3 PRKG1 IRAK1 RRAS CRTC2 TICAM2 MLKL DDX58 ACTB AKT3 MAPK14 TRAF6 RAP1A EGFR AKT3 APBB1IP DUSP10 PRKACA MAP3K8 CDC42 SRC RPS6KA4 RASA4B RALA NODAL GSK3B RALBP1 IRS1 PRKCA NRG4 RAPGEF3

KCNMB2 RHOA PIK3R5 PLCE1 RHOA RRAS2 NOS3 GSK3B RAF1 RGL1 TIAM1 ERBB4 RALGDS NOTCH1 SMO MTOR PRKCA GNAI1 PAK4 FASLG ROCK2 MLLT4 ADCY1 GNA11 NOTCH1 CREB3 CTNNB1 RAC1 PIK3R5 SRC RAP1A ERBB3 PFKFB1 EIF4B ETS1 RAC1 KRIT1 RAF1 NFKBIA PLA2G4B SLC2A4 PLD1 CHRM1 ORAI1 RALA RRAS2 VASP MAP3K7 RASSF5 AKT3 RIPK1 PGAM5 TRAF2 STK3 BAD FOXO6 MAP3K14 MLLT4 CRK NOS3 VASP MAPK1 CACNA1C MAP2K7 MAPK14 CDC42 CREB3 RRAS2 PLD1 ACVR2A GLI1 CDC42 PIK3R5 SPHK2 ERBB4 MAPK8

2016/4/8 19:14 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] 页 4 共 5

KEGG validation 305 306 307 308 309 310 311 312

RRAS GNB5 CSH1 STK4 NLK EGFR RIPK1

PLCE1 RASGRF1 IL22RA2 FOXO6 LEF1 MAP2K1 MAP3K7

2016/4/8 19:14 [activation] [activation] [activation] [activation] [inhibition] [activation] [activation]

页 5 共 5

Interactome-wide predictions 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76

2016/4/8 19:14

ABL1 WASF1 [activation] ACTG1 MAP3K1 [activation] ARRB1 JUN [activation] ARPC2 ARPC5 [activation] LNX2 NXF1 [activation] PRKCB GSK3A [activation] CDKL3 CCDC155 [activation] STMN1 TRPC5 [activation] DAPK1 UNC5C [activation] TERF1 STAG1 [activation] HSP90AB1 STAT2 [activation] VEPH1 GSTK1 [activation] CYTH1 ITGB2 [activation] SNCA GRK6 [activation] IGFBP4 IGF1 [activation] PTK2 ROCK1 [activation] EPRS MAP3K7 [activation] CCNB1 PPP1CA [activation;inhibition] CDK11B RANBP9 [activation] CEND1 EGFR [activation] CAMK2D CAMK2A [activation] MIF GABARAP [activation] TRO PRKCD [activation] LIN7C AMOTL2 [activation] QARS GADD45A [activation;inhibition] RIPK1 PTK2 [activation] TNF BTRC [activation] SH3BP2 PLCG1 [activation] ARHGEF7 PPP2R1A [activation] COPG1 ILK [activation] NPHP1 PAK2 [activation] SRPK3 DHX15 [activation] NRXN3 NLGN3 [activation] MYB COX7B [activation] IFT172 LHX3 [inhibition] PKM EGLN3 [activation] DNAJB1 OTUD4 [inhibition] NUP133 NUP153 [activation] RAD21 HSP90AB1 [activation] EXOC4 EGFR [activation] BUB1B APC [inhibition] RTN4RL1 OMG [inhibition] CDK11B HSPA8 [activation] ITGA4 DARS [activation] APC CTNNA1 [activation] RAN VRK1 [activation] CHEK2 MDM4 [activation;inhibition] LALBA B4GALT1 [activation] HTR1A GPR26 [activation] UNG RPA3 [activation] MNAT1 TSC1 [activation;inhibition] TGFB1 APC [inhibition] MAPT CAPN2 [activation] BCL2L11 YWHAB [activation] CASP3 CTNNB1 [activation] HSP90B1 TLR2 [activation] CBLB PTPN11 [inhibition] PPP1CA C1QA [activation] TPST2 CCR2 [activation] GRB2 CKAP5 [activation] PPP3CB SOCS3 [inhibition] LHX1 FOXA2 [activation] LRRK2 PRKCZ [activation] HSPG2 BMP1 [activation] DDX24 POLA2 [activation] CTBP2 EHMT1 [activation] ESD TRAF6 [activation] PIN1 VCAM1 [activation] ERCC1 USHBP1 [activation] STX11 SNAP25 [activation] CUL3 CASP8 [inhibition] DSP CASP7 [activation] PRMT1 NCOA1 [activation] MYC PCBP1 [activation] MIF WDYHV1 [activation] LCK PTPRF [activation;inhibition] 页 1 共 454


2016/4/8 19:14

HIST3H3 ING2 [activation] ENO1 ABI2 [activation] RALBP1 HSF1 [activation] PFKFB2 YWHAH [activation] MFN2 BAK1 [activation] SERPINE1 IGFBP5 [inhibition] CRELD2 RAC1 [activation] GEM KLC3 [activation] C6 GRB2 [activation] GABARAP MLH1 [activation] SH2D1B CD84 [activation] TIMM50 RIPK1 [activation] MMP2 ITGB1 [activation] MAP1LC3C ATG5 [activation] MAP4K4 RASA1 [activation] PLCG1 ARHGEF5 [activation] APC ZNF510 [inhibition] PTH1R SLC9A3R2 [activation] MAPKAP1 PRR5 [activation] USHBP1 STX11 [activation] CTTNBP2NL STK3 [activation] PTPN6 CTNND1 [activation;inhibition] PTPN11 TNFRSF1A [activation] CYP20A1 APP [activation] TBC1D3C RAB5A [activation] KIR2DS4 HLA-C [activation] CCDC36 MRFAP1L1 [activation] GADD45A GBP2 [activation] TP53BP1 TFDP1 [activation] ANAPC5 FZR1 [inhibition] TFG PTPN6 [activation;inhibition] NR1H3 RXRA [inhibition] TEC LYN [activation] PARP10 CASP8 [activation] PAFAH1B3 DDX24 [activation] YWHAB PUM1 [activation] EPOR PTPN11 [activation;inhibition] PRR14L PPP2CA [inhibition] YWHAQ TSC1 [inhibition] ERAS RAF1 [activation] PRNP CSNK2B [activation] RAN SSRP1 [activation] ICT1 MTIF2 [activation] ABT1 PRNP [activation] STK24 CASP3 [activation] RIT2 MLLT4 [activation] RPA1 CCNB1 [activation] RALA ARF6 [activation] SMAD2 PIK3CA [activation] SMARCA2 H2AFX [activation] SH3GL1 LRRK2 [activation] DDX24 UBE2I [activation] GAB2 ETV6 [activation] VCAM1 ELANE [activation] ATG5 SNCA [activation] JUP FHL2 [activation] SRI PSEN2 [activation] MSTO1 NR1H3 [activation] CRK NTRK1 [activation] TP53 LRRK2 [activation] MAPK1 DCC [activation] CDK3 CDK5 [activation] TP53 TBC1D4 [activation] JUP INSIG2 [activation] LRRK2 MTHFD2 [activation] GDNF RET [activation;inhibition] MAP3K2 MAP3K5 [activation] ERBB2 EZR [activation] GNB5 MCM2 [activation] FLT1 KIAA1524 [activation] KRT19 GRB2 [activation] UFM1 RPS6KA6 [activation] PAXIP1 WDHD1 [activation] EIF3F TRAF6 [activation] NOSTRIN NOS3 [activation] LZTS2 GRB2 [activation] 页 2 共 454


2016/4/8 19:14

ANAPC10 PPP2R1A [activation] PRKY HSP90AB1 [activation] GAB2 NCK1 [activation] HSPD1 CASP9 [activation] KAT2A IRF2 [activation] TRAF2 SPHK1 [activation] RIBC2 USHBP1 [activation] GAB2 YWHAG [activation] HSPA8 JAK2 [inhibition] NFKB1 ERCC6 [activation] CPNE2 CDKN1A [activation;inhibition] RHOC ARHGAP1 [activation] EGFR BECN1 [activation] RPS6 ESR1 [activation] PARP11 RNF114 [activation] PPP1R12A YWHAZ [activation] TSC1 FTH1 [inhibition] CCNB1 BRCA1 [activation] ZNF24 DNER [activation] STAT1 UBE2I [activation] FYN FLOT2 [activation] PAK1 SRSF5 [activation] TBK1 EGFR [activation] CR1 CR2 [activation] VCAM1 BUB3 [activation] CAMK2B FAM171A2 [activation] SRC IL6R [activation] AURKB PPFIA1 [activation] TSC2 FBXL6 [inhibition] H2AFX BIRC5 [activation] PDZK1 SLC9A3 [activation] APP TBCD [inhibition] FAF1 VAPB [activation] EHMT2 ANKRD28 [activation] RELA PPARGC1A [activation] YY1 SMAD4 [activation] CNKSR1 ZDHHC17 [activation] KCNB1 KCNG2 [activation] TOLLIP DAB1 [activation] SLC30A2 TNFRSF12A [activation] PRKAA2 USHBP1 [activation] HIST1H2BM ITGA4 [activation] ID4 PLCG1 [activation] FAM83D GADD45A [activation;inhibition] CCL2 ORC4 [activation] TP53BP1 HIST1H3A [activation] CAD MAP3K3 [activation;inhibition] MMP9 PLG [activation;inhibition] GHRL MLNR [activation] PRKAA1 VPS37B [inhibition] IGHA1 SKIV2L2 [activation] RIMS1 CAMK2A [activation] ATM TERF1 [activation] CDC20 CDKN1A [activation;inhibition] CAD GRB2 [activation;inhibition] APOE LRP8 [activation] MAVS TRAF3 [activation] PLEC VCAM1 [activation] SIRT1 HNF4A [activation] CRK PCDHA12 [activation] TGM2 PAK1 [activation] TET2 SMARCA4 [activation] AURKA MDM2 [activation] BCL2L2 BAK1 [activation;inhibition] ATF3 SUV39H1 [activation] PRKACA RXFP1 [activation] SOCS1 PDCD1 [inhibition] PAXIP1 KDM6A [activation] RGS7 GNAQ [activation] THEM6 ESR1 [activation] RARA KAT2B [activation] CYFIP1 LRRK2 [activation] WSB2 NUDC [activation] MTOR NBN [activation] SRGAP2 RAC1 [activation] RMND5A MAEA [activation] 页 3 共 454


2016/4/8 19:14

KIR2DL5A PTPN6 [activation;inhibition] EGFR ICAM1 [activation] SOX9 CREB1 [activation] U2AF2 FTSJ1 [activation] SRPK3 NOP2 [activation] GABARAP YWHAZ [activation] MAST3 EIF2S2 [activation] NUP214 RANBP2 [activation] CDK11B TH [activation] TMEM173 TRAF3 [activation] TFRC FBXO6 [activation] BMP3 WFIKKN2 [activation] RAD21 EIF4G1 [activation] DPP4 CXCL10 [activation] SLC9A3R1 YES1 [activation] CCR1 STAT3 [activation] PIK3R1 TGDS [activation] ARHGAP9 MAPK1 [activation] OPRD1 GNAI1 [activation] RAC1 RASGRF1 [activation] APP TEK [activation] CDC37 MOS [inhibition] ZNF142 MAPK14 [activation] NRP1 FGF2 [activation] SMURF1 FBXL15 [inhibition] CD3D PDIA2 [activation] EIF2B3 FBXO6 [activation] TP53 SRPK1 [activation] RAC1 WASF2 [activation] QRICH2 MAGEB2 [activation] PDGFRL FBP2 [activation;inhibition] ICT1 ALDH1L2 [activation] APH1A GLP1R [activation] ILK PARVG [activation] SLC25A6 TRIP6 [activation] ANXA4 SMPD1 [activation] MEPCE ACTG1 [activation] NUP153 AIM2 [activation] MAVS FADD [activation] SNTA1 ADRA2A [activation] EGFR EXOC6B [activation] ITGAD ICAM3 [activation] CDC7 CDK2 [activation] RAP1B MAP3K14 [activation] IRF3 RBL2 [inhibition] SOCS1 TCEB2 [inhibition] ERBB3 SH2B3 [activation] TNFRSF10D CYCS [activation] LIMS1 SMURF1 [inhibition] TRAF6 RRAGC [activation] PLEKHJ1 TGFBR1 [activation] LCP2 PTPN6 [activation;inhibition] EIF4G2 PTBP3 [activation] MYC EXOC4 [activation] SERPINB13 PLG [inhibition] IGSF21 PAEP [activation] AURKB HIST1H3A [activation] SMAD3 PITX2 [activation] TBK1 PROS1 [inhibition] SRPK1 PRM1 [activation] NXF1 CCDC25 [activation] RAB3GAP2 RAB3GAP1 [activation;inhibition] ABL1 BCR [activation] JAK3 PRMT5 [activation] BMPR1B BMPR1A [activation;inhibition] CCDC87 ESR2 [activation] CUL1 RICTOR [activation] CSNK1A1L ARRB2 [inhibition] SPECC1 NXF1 [activation] VRK3 RAN [activation] CLIP1 NR3C1 [activation] YWHAZ RASAL3 [activation] NXF1 DPY19L4 [activation] CRY1 PER1 [inhibition] ACVR1B SMURF1 [inhibition] CD40 OGT [activation] 页 4 共 454


HDAC2 BUB1B PPM1D H2AFX IL7R YWHAE FAM117B MYC RAF1 CALM1 CASP8 CDH13 RASA1 PTPRJ GLI3 SMAD1 TNFRSF1A NTRK3 IRAK3 DDX54 SRPK3 HOXD12 MEIS1 KIF3A GRB2 MET ITK SGK1 CBR3 RPTOR IKBKB MLH1 IGKC NFKB1 FBXW11 PTPRJ FLT3 TRAF1 RIPK1 INADL CNKSR2 ANAPC11 CDC23 HSP90AB1 TRAF6 BECN1 ESR2 SUPT6H RICTOR YWHAZ CCNI AKT1 CTLA4 STAT5B TGFB1I1 SMAD4 EFNA2 ZHX1 TLN1 OBSL1 SIRT1 MAPT FSCN1 FTSJ1 PGRMC1 ATG5 PTPN1 CRK TP53 RCN2 TMSB10 FOS APP CTF1 RBL2 GSTM3 YWHAB EIF4E2 VASN TGFB2 RFC2 PITX2 RXRA RAC3 FAS RIF1 PLSCR1 EP300 CMKLR1 TPST2 MDM2 ATF4 LAMTOR5 SMAD4 PAK4 ARHGEF2 IKBKB CDC37 ABL2 TPD52L1 SCIN GRB2 PAG1 ABL1 IGSF1 ACVR2B AMH EGFR SRPK2 BRD3 TLR2 RAC1 TTK APP HSPB2 TRAF2 SRC NR1H2 GAB2 BCR KIDINS220 MCM7 ARHGEF6 ACTR3 ARPC1B GABRG2 PRKCA CSNK2B PLXNA3 GADD45A IGHM CFL1 HSPH1 RELA TP53BP1 JDP2 EP300 ZAP70 PTPN3 POLD2 CCHCR1 APP MAPK11 HDAC11 HHIP RYR1 CAMK2G TAF1B APP

2016/4/8 19:14

[inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] GRB2 [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] STK32B [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] NGFR [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] 页 5 共 454


2016/4/8 19:14

FSBP CDC23 [activation] GH1 ERLEC1 [inhibition] LRRFIP2 GRB2 [activation] FASTKD5 MLH1 [activation] ZBTB48 ILK [activation] GNAI3 GPSM3 [activation;inhibition] TIAL1 RPA1 [activation] GEM PNMA1 [activation] PLCL2 DSCAML1 [activation] TNFSF11 LMO4 [activation] NFKBIA BARD1 [activation] FAM9B SNAP29 [activation] CDC5L CALM1 [activation] HSPB1 F13A1 [activation] TRAF6 RPL38 [activation] KLHL21 AURKB [activation] MARS MDM2 [activation] HSPD1 CDH1 [activation] RPS19 FGF2 [activation] HSP90AB1 KLHL6 [activation] GRN FAM131C [activation] MAST3 EIF2A [activation] ASS1 ELN [activation] TAGLN2 H2AFX [activation] IRS2 PTPN6 [activation;inhibition] CRK OGN [activation] LATS1 OFD1 [inhibition] DVL2 PRKCA [activation] RAD51B HELQ [activation] ACTR1A SMURF1 [inhibition] CCNA2 UBTF [activation] SKAP1 SRC [activation] PTK6 AR [activation] PGR RELA [activation] RNF2 CASP3 [activation] ITGB1 FHL2 [activation] RAB5C RAB5A [activation] APP NGFR [activation] BTRC RAPGEF2 [activation] RANBP2 LGR4 [activation] TNFSF13 SDC2 [activation] ATG5 CDKN2A [activation] RAB8B GRB2 [activation] RAP2B RALA [activation] LRRK2 HIST2H2AA3 [activation] HGF F11 [activation] RNF2 ACACA [activation;inhibition] GP6 TGFB1I1 [activation] DNM2 CDC5L [activation] SMARCA2 CDX2 [activation] CNTNAP1 NFASC [activation] ATM HDAC6 [activation] SUMO4 NR3C1 [activation] CDK13 CDK4 [activation] COBL RPA2 [activation] H2AFX ANXA5 [activation] DDX58 UBE2D1 [inhibition] SPP1 HMGN1 [activation] EGFR EPHB4 [activation] ESR2 PROSER2 [activation] CDK7 SRPK2 [activation] LRRK2 LRP6 [activation] MME PIK3R1 [activation] PRLR VAV1 [inhibition] NUP62 C1orf216 [activation] EGFR KPNB1 [activation] DVL3 C8orf33 [activation] SRGAP2 SRGAP2C [activation] C2orf44 ANXA1 [activation] EIF3E SMURF1 [inhibition] PPP3R2 AURKA [activation] GADD45A GNB2 [activation] LTBP4 CACNA1A [inhibition] FZD1 UBC [activation] TRPV1 TRPV2 [activation] RAB5B EEA1 [activation] 页 6 共 454


2016/4/8 19:14

RBL1 BRF1 [inhibition] GRB2 REPS2 [activation] EPHA2 HSP90AB1 [activation] SMAD3 BPTF [activation] HTR2A DLG4 [activation] VCAN XCL1 [activation] NFKB1 TBK1 [activation] DDX5 DAPK1 [activation] CDK11B YWHAZ [activation] AR SHC3 [activation] CDK1 ABL1 [activation] PLK1 CENPQ [activation] SIRT1 CDK1 [activation] ARRB1 MYO1C [activation] TERT CTNNB1 [activation] INSIG2 PSMD13 [activation] PBX1 NR3C1 [activation] ATG5 CCDC12 [activation] PRKCA VCL [activation] GNA11 ELAVL1 [activation] TNS3 KIT [activation] MECOM FOSL2 [activation] CHEK2 XRCC1 [activation] FCRL4 TFF1 [activation] CTBP1 EHMT2 [activation] ICT1 MTG1 [activation] RPA2 KCNAB2 [activation] GRB2 CORO1B [activation] FGFR1 IL17RD [activation] NKAPL LYN [activation] GABARAPL2 ACTB [activation] DNAJB1 BAG2 [inhibition] ANXA5 ASB9 [activation] IL6ST IL31RA [activation] SPOP DUSP7 [inhibition] PIAS1 ESR1 [activation] PTPN1 NTRK2 [activation] DEGS1 EGFR [activation] SUMO3 HIF1A [inhibition] FYN SUV39H2 [activation] UHRF1BP1L YWHAB [activation] BRCA2 STAT5A [activation] RAB5A GDI2 [activation] HSPBP1 HSPA8 [inhibition] MEPCE BARD1 [activation] SYK CTTN [activation] AXIN2 SMAD1 [inhibition] AR NRIP1 [activation] PTPN6 PAG1 [activation;inhibition] HSPA5 BCAR1 [activation] CALCA RAMP2 [activation] ILK AUP1 [activation] GAPDH ICAM1 [activation] PXN GIT2 [activation] TNR MYC [inhibition] IRS2 YWHAG [activation] STAT6 NCOA3 [activation] CTNNA1 CTNNA3 [activation] DNAJA1 CUL1 [inhibition] LYN CDK4 [activation] EDA FURIN [activation] TICAM2 TLR3 [activation] KIAA1377 LPL [activation] FAS UBE2I [activation] BCAM LAMA5 [activation;inhibition] EGFR ACTA1 [activation] IGHA1 GDF10 [activation] KIT BTK [activation] GRB2 NKD2 [activation] AURKA LYPD3 [activation] STK11 SPDEF [activation] CRKL FYB [activation] HIST2H3A VCAM1 [activation] GRK6 FSHR [activation] WAS DNM2 [activation] SH3KBP1 PSRC1 [activation] 页 7 共 454


2016/4/8 19:14

TULP3 SIRT1 [activation] TNFRSF14 DHX9 [activation] KDELR2 PARP2 [activation] CDC5L TRAK1 [activation] SHC3 GAB1 [activation] DKC1 NXF1 [activation] ARSA BMPR2 [activation] ARPC5 EGFR [activation] RPA1 ANXA7 [activation] FANCD2 FSCN1 [activation] NXF1 POLE2 [activation] CASP3 THAP11 [activation] RELA C1QB [activation] SP1 HIF1A [activation] NUDCD3 PAFAH1B1 [activation] ACTN1 HSPB1 [activation] PRKCI CRX [activation] MOS FKBPL [activation] MAP2K1 NFE2L2 [activation] RAB5C CD247 [activation] ANG TDGF1 [activation] HDAC1 SYK [activation] DOCK1 NCK2 [activation] YWHAQ CDK11B [activation] FGFR2 S100A14 [activation] PRKACA GP1BB [activation] PLAU SERPINA5 [inhibition] HDAC1 STAT3 [activation] JMJD6 HMGXB4 [activation] ESR1 U2AF2 [activation] ERBB2 BLK [activation] RAC1 PAK6 [activation] NCK2 CBL [activation] BCAR1 MMP14 [activation] TIMP1 FBXO6 [activation] GSK3B ACSBG1 [activation] SMCHD1 ITGA4 [activation] ILK ARRB1 [activation] VDR PRCP [activation] GAB1 NCK1 [activation] MAPRE1 VCAM1 [activation] LRCH1 DOCK8 [activation] YWHAE MARK3 [activation] CHD7 BRD7 [activation] TFDP2 E2F2 [inhibition] EGFR RCN2 [activation] TNFRSF14 HPRT1 [activation] CAV1 IGHA1 [activation] RHOA FADD [activation] AURKB SUMO1 [activation] FGFR2 RHOBTB2 [activation] DVL3 CTNNB1 [activation] GRB2 THEMIS [activation] PRKDC APLF [activation] CDKN1A TNIP2 [activation] FAAP24 STRA13 [activation] SUMO3 NFE2L2 [activation] TESK1 YWHAB [activation] PIK3R1 CTLA4 [activation] FASN PTPN11 [activation] TGM3 GABARAPL2 [activation] ATAD3B ICT1 [activation] TGFBR2 PAK1 [activation] SUV420H1 YWHAQ [activation] RAD21 WFDC5 [inhibition] MARK3 PNPLA2 [activation] TGFBR1 FANCL [activation] METTL17 SPERT [activation] GRB2 RPL18A [activation] IKBKB TNF [activation] PPP2CA ESPL1 [inhibition] MCM3 PPP2R1A [activation] DOK5 NTRK2 [activation] IKBKB MAP3K13 [activation] ITCH GSN [activation] TGFB1 PSMC3IP [activation] 页 8 共 454


2016/4/8 19:14

NCOA2 PGR [activation] ROCK1 ARRB1 [activation] PACSIN1 WASF2 [activation] NFE2 KAT2B [activation] RICTOR SFN [activation] TRAPPC8 TRAPPC6B [activation] HSPA8 NLRP12 [inhibition] TRAP1 CDK5 [activation] ANGPTL3 ITGB3 [activation] LAT ZAP70 [activation] TMC4 FLT1 [activation] SMARCC1 GATA1 [activation] EPSTI1 AKT1 [activation] GRB10 SRC [activation] YWHAE PRPSAP2 [inhibition] RNF41 APP [activation] DOCK8 DOCK6 [activation] STAT1 PRKCE [activation] CCNE1 PRC1 [activation] ABI2 RAC1 [activation] HLA-B AKR7A2 [activation] MAP1LC3B DSG1 [activation] PIK3CB YWHAQ [activation] UBE2D1 HIF1A [inhibition] WIPI1 PPA1 [activation] BRCA1 CCND1 [activation] MAPK6 MTG2 [activation;inhibition] GRM2 RGS12 [activation;inhibition] PTPRJ PXN [activation] SHC1 SH2B2 [activation] MACF1 SKIL [activation] RASSF1 CNKSR1 [inhibition] PKN1 CASP3 [activation] ADRB2 WNK1 [activation] STK3 MAP1S [activation] PIK3R3 FGB [activation] NUPR1 EP300 [activation] ARPC1B ARPC5 [activation] RCN2 TRAF6 [activation] CD8B CD8A [activation] NXF1 TMEM222 [activation] PIAS1 PIAS2 [inhibition] PPP3CA RCAN1 [activation] RAD21 KPNB1 [activation] NRAS SRI [activation] PPP1CA RB1 [activation;inhibition] METTL25 APP [activation] CASP3 PTMA [activation] MAPK12 DLG3 [activation] MIB1 JAG1 [activation] ZSCAN26 LRRK2 [activation] GRB2 ARHGEF11 [activation] PIK3R2 DYDC1 [activation] MEF2A TBP [activation] CHUK HSP90AA1 [activation] EGFR HOXC10 [activation] CASP3 BLM [activation] RADIL SMYD2 [activation] ST14 PLAU [activation] YES1 YAP1 [activation] RBM41 RAC3 [activation] DEK KAT2B [activation] CCSER2 CRADD [activation] MS4A1 IGHD [activation] SMAD3 FOXO3 [inhibition] RB1 CCNB1 [activation;inhibition] RPA1 CAPRIN1 [activation] EGFR RPA3 [activation] FYN CD44 [activation] SRPK2 CLK1 [activation] LAMTOR5 EIF4B [activation] IKBKG EGLN3 [activation] CAMKK1 YWHAH [activation] ANKRD28 NEK4 [activation] ABL2 BCR [activation] CKAP4 EGFR [activation] 页 9 共 454


2016/4/8 19:14

SMAD2 PSG9 [activation] BCL7C BRD7 [activation] CYCS FDX1 [activation] TRAF2 PGBD1 [activation] NCAPG EGFR [activation] CCDC33 TGFB1 [activation] FAN1 YWHAE [activation] SMURF1 E2F7 [inhibition] LAX1 GRB2 [activation] MAP2K3 ELK1 [activation] EPHB2 KSR1 [activation] IL2RG ICAM1 [activation] GRIP1 CREBBP [activation] HSPA5 IKBKB [activation] TRAF5 MAVS [activation] PTPRE GRB2 [activation;inhibition] TBC1D22B CCDC67 [activation;inhibition] HNRNPA1 MLLT4 [activation] MDM2 DDX3Y [activation] GTLF3B TRAF2 [activation] STAC LRRK2 [activation] RRAS2 RASIP1 [activation] RIPK2 HSPA1L [activation] YWHAG ARRB2 [activation] CXCR4 PTPRC [activation] UBE2D3 NFKBIA [activation] TRAF3 TNFRSF4 [activation] CACNA1A KALRN [activation] DNM1L SH3GL1 [activation] IFRD1 CTNNB1 [activation] BCL2L11 PRKACA [activation] RPA3 TIPIN [activation] EIF1AX EIF3C [activation] DMTF1 CCND1 [inhibition] SNX33 FASLG [inhibition] ARHGAP21 RHOA [activation] LRRK2 MCM3 [activation] ITIH5 CHEK2 [activation] LYN CSF2RB [activation] NUP62 ABI2 [activation] ARHGDIA UFM1 [activation] PRKDC USF1 [activation] CDK5 MBP [activation] MAP9 EP300 [activation] RASA1 PLCG1 [activation] PKIG RAB25 [inhibition] HELLS MYC [activation] CLN6 ILK [activation] DVL1 DYNLT1 [inhibition] HSPA7 CFTR [activation] STK4 ARHGAP18 [activation] MAP3K2 NFKBIA [activation] HSF1 UBE2I [activation] RPA3 IQGAP1 [activation] CDK1 RPA2 [activation] WDR26 BARD1 [activation] PPARG ZYX [activation] PIK3R1 WASF3 [activation] NXF1 CDC23 [activation] A2M IL10 [activation] CD7 PI4K2A [activation] MAP9 TP53 [activation] DNM2 GDF9 [activation] TLR2 ANP32B [activation] VCAM1 SRSF1 [activation] ACTA2 EP300 [activation] EP300 CCNT1 [activation] NCOA1 STAT3 [activation] SMC4 CASP4 [activation] INSIG2 HSPA6 [activation] THBS1 CFH [activation;inhibition] MAPRE1 PIK3R4 [activation] GSK3B IQCG [activation;inhibition] HNRNPC TRAF6 [activation] TAF1C TAF1B [activation] SRPK2 LUC7L [activation] 页 10 共 454


2016/4/8 19:14

NCOA3 FOS [activation] GRK6 ITGA5 [activation] TH PRKACA [activation] BCL2L1 BLK [activation] ACTR1A HLA-B [activation] CDKN2C MAPK10 [activation] ENO2 SNUPN [activation] SMAD3 IRF7 [activation] MAP2K1 CTNNA1 [activation] CFLAR FKBPL [inhibition] LNX2 IGSF5 [activation] CBL EIF5B [activation] MET BCAR3 [activation] NUP88 NUP214 [activation] PNPLA2 CYTH2 [activation] TERF1 UTP14A [activation] SH3RF1 SEMA6A [activation] ARFIP2 ARF1 [activation] FOXO3 ERBB2IP [inhibition] GEM KCTD9 [activation] LAMA5 CRKL [activation] SRPK1 CIAO1 [activation] PTPRC PDGFRB [activation] CDKN1A CDK14 [activation;inhibition] PRKAA1 SSX2IP [inhibition] LRRK2 ADCK3 [activation] GSG1 TRAF2 [activation] KCNA5 SNTA1 [activation] ITPR2 BANK1 [inhibition] PCBP1 TP53 [activation] GPSM2 NUMA1 [inhibition] MAD2L1 KLHL13 [inhibition] STAB2 MAPK14 [activation] CACNB1 APP [activation] RCAN1 STAT2 [activation] APP KCNAB3 [activation] CASC3 AKT1 [activation] TTC3 AKT3 [activation] NOTCH1 PDS5A [activation] PXN EGFR [activation] ELSPBP1 MYF5 [activation] SMAD4 CCDC180 [activation] RASSF10 CCDC85C [inhibition] CDH1 ACTG1 [activation] CTNNB1 UBE2D1 [inhibition] FAM129A AKT1 [activation] STAT1 HDAC3 [activation] RAC1 CHN1 [activation] GPRIN2 SFN [activation] TUB GRB2 [activation] FHOD1 GRB2 [activation] GNAS ADCY5 [activation] EIF2B1 MRPL4 [activation] HLA-C NUDC [activation] SMPD1 CASP8 [activation] GSKIP GSK3B [inhibition] F2RL2 CDH5 [activation] GOLGA2 BARD1 [activation] ERCC3 SRPK2 [activation] IGHA1 TBC1D19 [activation;inhibition] PRKACB HSP90AB1 [activation] KLRK1 MICA [activation] RHOA TRPC1 [activation] MAPK8 YWHAZ [activation] MAP3K12 TGM2 [activation] MTNR1A RAB10 [activation] S1PR3 GNAI1 [activation] BCL2 PKMYT1 [inhibition] COPS4 IKBKB [activation] CDKN1A SMAD4 [activation;inhibition] IRF3 IKBKE [inhibition] HSP90AA1 STK36 [activation] GRB2 CELF2 [activation] KSR1 NME1 [activation] ACTN1 CACNA1A [activation] YWHAZ IRS2 [activation] 页 11 共 454


2016/4/8 19:14

SST SSTR5 [activation] CCND1 FBXW8 [inhibition] BHLHE41 SIRT1 [activation] PAK1 PAK2 [activation] ILK FBL [activation] ESR1 RARA [activation] AR ADAM10 [activation] MCM7 HIPK4 [activation] SOS2 ESR1 [activation] APP ELK1 [activation] GAB1 FRS2 [activation] GABARAPL2 VDR [activation] SMAD1 ERBB2 [activation;inhibition] DVL1 CTNNB1 [activation] CLU PRNP [activation] PRMT5 YWHAB [activation] ODF2L NXF1 [activation] KCTD3 HSPB1 [activation] OBSCN DNAJB5 [inhibition] SORL1 FURIN [activation] STAT1 MCM5 [activation] HOXB1 PAX6 [activation] TP53 GTF2H1 [activation] GABARAP HNRNPA1 [activation] SMG9 TRAF2 [activation] CXCR4 HSPA8 [activation] SUMO2 RAN [activation] CD247 NCR1 [activation] FLNA ICAM1 [activation] EGLN1 MAGEA11 [activation] F2RL2 FYN [activation] STX5 STX4 [activation] ZSWIM8 AURKA [activation] CD44 MMP9 [activation] ABL1 MAP4K5 [activation] CASP4 TRAF6 [activation] BUB1 PPP3R2 [activation] RHOA GNB2L1 [activation] MAP1LC3A EPHA7 [activation] KIAA0232 YWHAZ [activation] F11R MLLT4 [activation] DHPS MAPK3 [activation] EFHC2 NCK2 [activation] MAVS PCBP2 [activation] CASP8 PSMC3IP [activation] MAPK3 PTPRE [activation;inhibition] IGF2 IGFBP2 [activation] SEMA4C NOTCH2NL [activation] ILK CAV1 [activation] OSMR JAK2 [activation] MYC FANCD2 [activation] SLC9A3R1 CAPN6 [activation] CCL19 CCL22 [activation] HSPA5 SREBF2 [activation] PLG THBS1 [activation] SMARCA4 ACTB [activation] KMT2A PPP1R15A [activation] NBN HIST1H3A [activation] CBLB TGFB1I1 [inhibition] ATG7 APP [activation] ALK SHC1 [activation] SNCA WDFY3 [activation] MDM2 ACACA [activation;inhibition] EXT1 CNTF [activation] NUMB PRKCE [activation] CPSF3 CDC5L [activation] TULP3 WNK1 [activation] CCNL1 CDK11A [activation] SHC1 CRKL [activation] TLR2 TICAM1 [activation] KCNB2 KCNG4 [activation] MIF VHL [activation] GRB2 ARPC3 [activation] DDX24 FADD [activation] KPNB1 NFYA [activation] BARD1 TP53 [activation] 页 12 共 454


2016/4/8 19:14

LRP1 ANAPC10 [activation] GNB2L1 IGF1R [activation] HSP90AA1 NPAS2 [activation] NMI STAT5B [activation] HSP90AA1 MET [activation] ESR2 SP1 [activation] CDC6 CCNE1 [activation] CCR1 CREB3 [activation] FANCE FANCC [activation] ZBED5 SMAD4 [activation] LYN FCGR2B [activation] SMAD7 HDAC1 [activation] TNKS1BP1 CDC5L [activation] NCOA4 RXRA [inhibition] SRSF1 CDK6 [activation] SGK1 PA2G4 [activation] ABI3 MRFAP1L1 [activation] MYD88 SPOP [activation] PIK3R1 SOS2 [activation] PPP2R5A PPP2R1A [activation] NXF1 MRPL24 [activation] SPI1 CEBPB [activation] GADD45G ESR1 [activation] EIF3D YWHAZ [activation] DYRK1A SRSF5 [activation] CD81 GAPDH [activation] SAV1 LATS1 [inhibition] FHL2 E2F4 [inhibition] SERPINA1 ELANE [inhibition] MAP1LC3A ENO2 [activation] SPEN DLX5 [activation] AIRE PIK3R1 [activation] TGM1 GABARAPL1 [activation] ADRBK1 EGF [activation] SH2D1A AR [activation] RARA HNRNPL [activation] SARM1 IRAK1 [activation;inhibition] TSSC4 TAB1 [inhibition] HIST1H3A BRD7 [activation] FLT1 SOGA1 [activation] IGSF21 CRCT1 [activation] NXF1 ABCF2 [activation] PALB2 BRCA2 [activation] YTHDC2 TP53 [activation] IQGAP1 PTK2 [activation] RELA PIN1 [activation] SRC TRPV4 [activation] ATF2 TMED10 [activation] MITF UBE2I [activation] ENO1 TCAP [inhibition] GRB2 MYO18A [activation] CEACAM6 CEACAM5 [activation] STMN1 SESTD1 [activation] CDK8 CEBPB [activation] ATM VPRBP [activation] IDE INS [activation] GSN FBXO25 [activation] GRB7 PTK2 [activation] SOS1 EPS8 [activation] ACTB CSNK2B [activation] APPL1 GPC3 [activation] F7 SLX4 [activation] TRAK1 SKIL [activation] MYO18B ACTB [activation] STK4 SNX5 [activation] HSP90AB1 NEK11 [activation] PSIP1 OBSL1 [activation] HSP90B1 ATF2 [activation] ERLIN1 VCAM1 [activation] CXCR4 ELANE [activation] BIRC6 VCL [activation] PRKCQ BCL10 [activation] CASP2 CFLAR [activation] PTK2B DOCK8 [activation] MDM2 JUP [activation] FYN CD79A [activation] 页 13 共 454


2016/4/8 19:14

RAN NUTF2 [activation] STX3 STX4 [activation] PRKCE HSP90AA1 [activation] ADCYAP1 FAP [activation] SP1 GTF2B [activation] CGA FSHB [activation] RRAS2 TRAF2 [activation] NFE2L3 PPARG [activation] DDIT3 TNFSF12 [activation] DVL3 WWTR1 [activation] CDK7 RPA3 [activation] ACTN3 TRAF2 [activation] PHGDH MAPK6 [activation;inhibition] SERPINC1 PLCG1 [inhibition] PARD3 AMOTL2 [activation] GSK3B CREM [inhibition] CCDC8 GNB1 [activation] POU3F1 HMGB2 [activation] ATP1B1 BACE1 [activation] TGFB1 LAMTOR5 [activation] FYB LCP2 [activation] PTPN1 SNAI1 [activation] UBTF CCNE1 [activation] IL4R DOK2 [activation] MOV10 BID [activation] ADD2 FYN [activation] CSNK1E HES1 [activation] SHC1 DDR1 [activation] SHC1 SMAP [activation] MYC FASTKD2 [activation] BHLHE40 RXRA [inhibition] PVR CD96 [activation] PPP1CA BAX [inhibition] TRIP10 WASF1 [activation] BECN1 ATG5 [activation] ANKIB1 NR4A1 [inhibition] RRAS2 PTPN1 [activation] PCNA RECQL5 [activation] HSPA4 CDK5RAP3 [activation] DAB1 LGALS9C [activation] PFN1 PIK3R1 [activation] PDGFRA FBXO25 [activation] RAPGEF2 LAP3 [activation] AURKB PPP2CA [activation] ACTB SSH2 [activation] CLEC3B FGF13 [activation] PYHIN1 LAMB1 [activation] TP53RK NUP43 [activation] SNCA MAPK8IP1 [inhibition] MBP PDGFRL [activation;inhibition] HIST3H3 ITGA4 [activation] GRB2 NEXN [activation] PPARG MED1 [activation] DDX3X RAD51C [activation] CLOCK ARNTL2 [activation;inhibition] CHMP4B TP53 [activation] TIAL1 OBSL1 [activation] HIST1H2BJ CD81 [activation] PPP2R5B MAPK1 [activation] CFLAR NFKB1 [inhibition] RASA1 EIF1 [activation] BEX1 NGFR [activation] IL1A NFKBIE [activation] ZNF71 PRKCZ [activation] MYLK2 PCK1 [activation] TDGF1 ACVR1C [activation] DOCK7 GRB7 [activation] RPAP3 LRRK2 [activation] UBAC2 PRKDC [activation] JUN CREB3 [activation] CREBBP HLF [activation] BAZ1B HIST2H2AC [activation] RIPK1 LRRK2 [activation] ACTB ARRB2 [activation] STK11 SMARCC1 [activation] RIPK4 PRKCD [activation] 页 14 共 454


2016/4/8 19:14

MYB MAPK1 [activation] RALB CALM1 [activation] IL13RA2 ESR2 [activation] C20orf24 GCN1L1 [activation] UBE2H MARCH10 [activation] ROCK1 MYBPH [activation] MEF2A HDAC4 [activation] CSNK2B FGF2 [activation] SOCS2 TCEB1 [inhibition] AKT2 PRKCZ [activation] NXF1 OBSCN [activation] BRD4 GRB2 [activation] SHANK3 PAX6 [activation] PIK3R1 RB1 [activation] EP300 RPS6KA5 [activation] PEAK1 CRK [activation] NCR1 FCER1G [activation] SIRT1 MYC [activation] CASP3 WNK3 [activation] SUMO2 MYB [activation] RAD51 CHEK1 [activation] LRMP YWHAE [activation] ESR1 ARFGAP2 [activation] SMAD2 EIF4A2 [activation] HLA-B VDAC3 [activation] MAP1B LRRK2 [activation] EGFR PYCR2 [activation] TRAF2 TRIM42 [activation] SRPK2 TNFRSF10C [activation] RIT1 MLLT4 [activation] DDX50 ESR1 [activation] STAT3 TSLP [activation] SMAD3 EPAS1 [activation] YAP1 ERP44 [inhibition] SERPINE2 COL4A1 [inhibition] SRPK1 MAGEB1 [activation] SPTLC1 LRRK2 [activation] RAD21 AIRE [activation] APC GOLGA2 [inhibition] PPP2CA CAV1 [activation] IL6ST HCK [activation] RAC1 CDC42SE1 [activation] FANCI ARF6 [activation] CREBBP IRF7 [activation] PTPN12 GRB2 [activation] CRTC1 CREB1 [activation] MSTO1 EP300 [activation] PRKRIR DDX58 [activation] PAWR GRB2 [activation] SCFD1 LRRK2 [activation] HOXA3 ARPC3 [activation] EPAS1 EP300 [activation] ANXA2 FLT1 [activation] RPL26 EIF4A3 [activation] HIF1A JUN [activation] ILK ATP2A2 [activation] CCL3L1 CCR5 [activation] LATS1 SSX2IP [inhibition] SOS1 ZAP70 [activation] YWHAB MLLT4 [activation] IRAK3 LDB1 [inhibition] MAPK1 PEA15 [inhibition] RARA SP1 [activation] ODF2L PIPOX [activation;inhibition] JAK3 KIT [activation] ETFA UBA5 [activation] SIRPB1 TYROBP [activation] SPRY1 STAT3 [activation] MRPL43 SRPK1 [activation] SLC26A3 SLC9A3R1 [activation] FLNA SH2B3 [activation] GNAO1 FFAR2 [activation] ABI1 ITGA4 [activation] GNAI2 HSP90AB1 [activation] STIM1 TRPC1 [activation] TAF1C TP53 [activation] 页 15 共 454


2016/4/8 19:14

CHD8 CDC5L [activation] SLC6A1 HTT [activation] MYO18B CRK [activation] DDX39B GRB2 [activation] HIF1A EPAS1 [activation] IGF2 IDE [activation] GABARAPL2 PPP3CB [activation] BPNT1 TRAF6 [activation] FYN SYK [activation] ANXA2 SHC1 [activation] GNGT2 GNB3 [activation] FAM50A FOS [activation] PLCB1 TFCP2 [activation] SAG CHRM2 [activation] NRAS RAP1GDS1 [activation] NUP214 NXF3 [activation] ITGA4 MIF [activation] HRAS BLID [activation] SLC41A3 APP [activation] GLTSCR1 SRC [activation] IAPP RAMP2 [activation] LIMK1 CDC42BPA [activation] HSPB1 ILK [activation] ANXA7 PDHB [activation] CTGF LRP1 [activation] IRF1 SPI1 [activation] CACNA1C GNB1 [activation] RPA3 MYO1C [activation] SETD7 SOX2 [activation] BACE1 FLOT2 [activation] RPA3 MYO1F [activation] MAPK1 TH [activation] ANGPTL4 TGFB1 [activation] CCR5 DNM2 [activation] EPSTI1 PTPRJ [activation] TRIP10 CTNNB1 [activation] KCTD15 WIPI1 [activation] CDKN1B YWHAG [inhibition] RB1 FBP2 [activation;inhibition] EFNB2 GRM1 [activation] EP300 CLOCK [activation] EGFR SAMHD1 [activation] CALM1 TRAF2 [activation] CDK4 BRCA1 [inhibition] CALM1 GLP2R [activation] ITGA4 PRDX3 [activation] BMP1 LAMB3 [activation] ULK2 CSNK1D [activation] TUB SRC [activation] TULP3 ESRRG [activation] GMCL1 IL17F [activation] PAXIP1 SCCPDH [activation] HSP90AB1 RHOBTB1 [activation] DLG4 EFNB2 [activation] GRB2 TFAP2A [activation] PTH1R SLC9A3R1 [activation] NR3C1 NR4A1 [activation] CD4 HNRNPA2B1 [activation] MC1R MRAP2 [inhibition] GFRA1 SOCS3 [activation;inhibition] HSPA6 MAP3K3 [activation] PAX7 SRC [activation] SELPLG GALNT4 [activation] KPNA1 SKP2 [activation] RPTOR LAMTOR5 [activation] APP PPP1R17 [activation] YES1 THAP1 [activation] ITGB3 NUMB [activation] MARK4 CDC42 [activation;inhibition] FAM84B NOTCH2 [activation] SKP2 NLK [inhibition] WDR90 NUDC [activation] CKAP4 PRKCZ [activation] MAPK8 SNCG [activation] CFTR PPP2R1A [inhibition] ACTA1 VAV1 [activation] 页 16 共 454


2016/4/8 19:14

PIN1 SMAD2 [activation] JMJD6 GNA14 [activation] YWHAB CDC25C [activation] E2F3 DHX33 [activation] DVL1 SIPA1 [activation] IFNGR1 NFKB1 [inhibition] FOXJ1 GRB2 [activation] SHC1 GRAP2 [activation] TRAF6 MCM3 [activation] BHLHE40 BTRC [activation] RAD18 CDC7 [activation] PIK3R3 ESR1 [activation] EGLN1 ZNF281 [activation] RHOC LNX1 [activation] FGFR4 MTA3 [activation] ANXA7 QARS [activation] ARNT DIABLO [activation] LRRK2 HIST1H2BB [activation] GRB2 PPM1B [activation] TAF1B TBP [activation] HRG C1QB [activation] CCR1 CCL14 [activation] FANCC STAT1 [activation] GNAI1 PCK1 [activation] NEK11 MYC [activation] DBN1 BAK1 [activation;inhibition] CTSG F5 [inhibition] ENSA ENO2 [activation] CDC23 ANAPC15 [activation] NUTM2F MORN4 [activation] VASP PFN2 [activation] PIAS1 AR [inhibition] ARFGEF3 EGFR [activation] GRB2 HSP90AA1 [activation] SORBS1 ACTA1 [activation] SASH1 SFN [activation] TIMP2 PAICS [activation] HSPA4 HSPA8 [inhibition] HMGXB3 CDK4 [inhibition] SH3KBP1 MAP3K4 [activation] EGFR GNB2L1 [activation] PLCG1 GSN [activation] HIST1H4A DNMT3L [activation] ADAM17 PDIA3 [activation] APC MCM3AP [inhibition] MTNR1B GNAI2 [activation] RPS2 FGF3 [activation] SMARCD1 GRB2 [activation] ITGA4 NUP188 [activation] STAT5B PTPN11 [activation] ERICH2 TNF [activation] NOS2 YWHAE [activation] OLFM2 GNB5 [activation] CBLN4 SRPK2 [activation] ANXA7 CTSB [activation] UBE2R2 BTRC [activation] MAPK6 XPO1 [activation] ELANE CSF3R [activation] IKBKG VAMP3 [activation] DVL2 PPM1A [activation] RGPD4 PLK1 [activation;inhibition] PRKCA PPARG [activation] MAPK1 CDX2 [activation] NRAP VCL [activation] WBP11 ARF1 [activation] UBE2I DDX21 [activation] ATF2 CEBPG [activation] YAP1 SOCS6 [inhibition] TRAF3 TNFRSF14 [activation] XPO1 NUP50 [activation] MEP1A PTH [activation] PIK3R1 GABBR1 [activation] NOS3 ELAVL3 [activation] EIF4G2 MAGEA6 [activation] SMAD3 SMAD1 [activation] ESR1 LARS [activation] 页 17 共 454


2016/4/8 19:14

CSF2RB CSF2RA [activation] CCL4 CCL3 [activation] PIK3CA GABRB1 [activation] CAV1 PLD2 [activation] CLDN4 EPHA2 [activation] SERPINE1 VTN [inhibition] RAC1 HPS4 [activation] RARA KAT2A [activation] SRPK2 SNRPC [activation] HAND1 MYOD1 [activation] CDC25C EGFR [activation] LRRK2 RANBP2 [activation] GRHPR CDC7 [activation] NEDD9 CDH1 [activation] PPIF TP53 [activation] PLCG1 IRS2 [activation] CCNB1 CDC14A [inhibition] INCA1 EPHB6 [activation] YWHAE H2AFX [activation] SH2D3C SRC [activation] RASD2 SMAD4 [activation] SMAP1 APP [activation] MS4A12 PLLP [activation] CDC5L NSUN5 [activation] RBL1 CREG1 [inhibition] FAM53C YWHAE [activation] C8orf33 GABARAP [activation] ARHGEF11 CDC42 [activation] LRRK2 YWHAB [activation] CHTOP SRPK2 [activation] USP20 HIF1A [activation] CBL EPHA8 [activation] RGS7 PRKCA [activation;inhibition] CDK8 CCND1 [activation] FBXO5 ENO1 [inhibition] BCL6 EPHB6 [activation] HSPB1 SUMO3 [inhibition] GSK3B BZW2 [activation] HIST1H4A MAPK3 [activation;inhibition] MAPK1 SCNN1G [activation] IKBKG PRKCB [activation] TTK CDC27 [activation] MAP3K5 FAS [inhibition] MAPKAP1 NBN [activation] NR5A2 NRIP1 [activation] STK11 USP11 [activation] NXT1 PRKAB1 [activation] ROBO4 ENAH [activation] TIMP1 CD63 [activation] IQGAP1 GRB2 [activation] GNAO1 RIC8A [activation;inhibition] CD33 PTPN11 [activation] GRB7 FLAD1 [activation] ENGASE EGFR [activation] LCK DOK3 [activation] PML ZFYVE9 [activation] PLCG2 EPOR [activation] TIAM1 ANK3 [activation] CSK ARRB2 [activation] FLNA IKBKB [activation] ADRBK1 GIT2 [activation] BTBD2 TP53 [activation] RHOQ PFN1 [activation] WT1 MDM2 [activation] GRN KRTAP26-1 [activation] CDK1 PPP1CC [inhibition] YWHAZ HIST1H2BB [activation] RAF1 TBXA2R [activation;inhibition] SMARCB1 YWHAZ [activation] PTPN1 NTRK3 [activation] CASP4 PSEN1 [activation] NRAS RASSF5 [activation] SFN REEP4 [activation] ADRBK1 SNCA [activation] MCM6 MCM3 [activation] CCNG1 APP [activation] 页 18 共 454


2016/4/8 19:14

MYO18A MYC [activation] FBXO28 HSP90AB1 [activation] MST1R SRC [activation] PASK IL2RA [activation] YWHAZ FASN [activation] CDK1 EP300 [activation] WDR44 RAB11A [activation] GHRL AGRP [activation] FHL3 MAPK1 [activation;inhibition] SENP3 LRRK2 [activation] FSCN1 VCAM1 [activation] MAPK1 LIFR [activation] RXRA STAT1 [inhibition] MRE11A RRM2B [activation] BTK TEC [activation] HIST3H3 DEK [activation] FBXW11 RASSF1 [inhibition] ABI3 FARSA [activation] TBP MDM2 [activation] ASNS STRN4 [activation] HBEGF CD44 [activation] TIMP3 AGTR2 [activation] CS MDM2 [activation] FYN SKAP2 [activation] SIRPA PTPN11 [activation;inhibition] ABL1 GPR45 [activation] IGHG1 PDPK1 [activation] FARSA EGFR [activation] PMS1 ATR [activation] CSF1R YES1 [activation] IRS4 MTNR1B [activation] PRKCZ HIST1H1A [activation] VCAM1 DIAPH1 [activation] WFIKKN1 BMP4 [activation] MUC2 MLH1 [activation] TLR4 F2RL1 [activation] PTPRK CBL [inhibition] SRC MPZL1 [activation] KLHL26 NUDCD3 [activation] RLIM ISL1 [activation] ITGB7 DOK1 [activation] SOX9 HSPA1A [activation] DDX21 ESR1 [activation] PDPK1 PTPRG [activation] MKNK1 DDAH2 [activation] MYC CYR61 [activation;inhibition] CSNK2A1 PRKACB [activation] AURKB LATS1 [activation] CDKN1B DCLRE1C [activation;inhibition] TRIM24 STAT6 [activation] GABARAP NSMAF [activation] CDK6 VGLL4 [inhibition] EIF4EBP3 EIF4E [inhibition] EIF1AX PINX1 [activation] ESR1 RFX4 [activation] ENAH CDC5L [activation] YWHAB SLC9A1 [activation] CALCA NRD1 [activation] PLCL2 PPP1CA [activation] NXF1 MIEN1 [activation] SDF4 RAP1B [activation] MRPL4 DDX24 [activation] YWHAB MAP3K3 [activation] STK4 COPG1 [activation] LRRK1 PTPN11 [activation] C7orf31 KLHL40 [activation] CASP8 SPP1 [activation] SMAD1 CREBBP [activation] APC PROCR [activation] CBLB SPRY1 [inhibition] ICAM1 SART3 [activation] SSH1 ACTA1 [activation] GNAS CRHR1 [activation] PECAM1 SDC4 [activation;inhibition] CRK SHANK3 [activation] MAPK6 OSTF1 [activation;inhibition] 页 19 共 454


2016/4/8 19:14

TP53 TUBA8 [activation] WNK4 OXSR1 [activation] HDAC1 PPARG [activation] PRKCI IL1RAP [activation] LIMK1 PRKACA [activation;inhibition] NME7 CDK5RAP2 [activation] PML PYCARD [inhibition] ARRB2 AVPR2 [inhibition] RPA4 MUTYH [activation] IGFBP1 MMP26 [activation] FTSJ3 DDX56 [activation] VDAC1 TERT [activation] PROP1 CTNNB1 [activation] NEURL4 TP53 [activation] EPB41 EGFR [activation] RAP1GAP PFN2 [activation] PLG HRG [inhibition] EGFR VPS13A [activation] MAPK12 MAPK15 [activation;inhibition] TES EVL [activation] SIGLEC12 PTPN6 [activation;inhibition] MIPEP ILK [activation] VCL ITGA4 [activation] EIF2S2 KIAA1377 [activation] NBN CDK9 [activation] SMAD4 ARL5B [activation] DKC1 ARRB2 [activation] EP300 SRY [activation] HSPA1A BAG2 [inhibition] CHUK PPP2CA [activation] PFN1 VCAM1 [activation] CD40LG TRAF2 [activation] APP YWHAG [activation] YWHAG WEE1 [inhibition] HCK FLT1 [activation] CREBBP SRC [activation] RORC PPP1CC [inhibition] CD19 FYN [activation] ACVR2A BMP10 [activation] MYC ERP44 [activation] CRADD IL9R [activation] SHC1 ARAP1 [activation] LGALS13 ANXA2 [activation] NADK GRB2 [activation] CD3E JAK3 [activation] NCK2 NTRK2 [activation] ATP1A1 MDM2 [activation] NSD1 ESR1 [activation] SRPK1 CLK1 [activation] PRKDC NFKB1 [activation] PDCD6 ANXA7 [activation] LMO1 GATA3 [inhibition] MYC KALRN [activation] EIF4A3 GRB2 [activation] TRAF6 MARS [activation] RELA REPS2 [activation] SMARCB1 HDAC4 [activation] FTSJ1 RHPN2 [activation] ITGB3 FGA [activation] BCL6 PANX3 [activation] SOCS2 KIT [inhibition] EGFR GBF1 [activation] APP KISS1 [activation] PRMT2 E2F1 [inhibition] ATXN10 STYXL1 [activation] HSPB1 HNRNPD [activation] TP53 TRIM39 [activation] USP53 GRB2 [activation] MMP9 CXCL6 [activation] SREBF2 ITGB4 [activation] ACKR3 PECAM1 [activation] TRAF6 NGFRAP1 [activation] STIM1 CAV1 [activation] APP UNG [activation] STK38 HSP90AB1 [activation] FN1 GNAI3 [activation;inhibition] 页 20 共 454


2016/4/8 19:14

DLG5 TERF1 [activation] TIAM1 SDC3 [activation] PPP1R9B DRD2 [activation] CEBPB CREB1 [activation] EP300 NOXA1 [activation] APC CSNK1A1 [inhibition] ELAVL1 DDX39B [activation] ACTG1 EPS8L2 [activation] NRXN1 MACF1 [activation] CDC25C LCK [activation] APBA2 RELA [activation] ACTN3 YWHAZ [activation] DUSP15 PIK3R1 [activation] PIGR SGK1 [activation] SMAD2 BPTF [activation] MDM4 CHEK1 [activation;inhibition] CALML5 TGM3 [activation] SHC1 PLSCR1 [activation] RASA4 APMAP [activation] PGR SMARCA1 [activation] PROS1 PROC [activation;inhibition] ZAK RPS6KA5 [activation] AKT1 WNK1 [activation] DDX39B EXOSC9 [activation] CTNNB1 CCNA2 [activation] HSP90AB1 SETDB1 [activation] HDAC1 DDX17 [activation] ARHGDIA FADD [activation] THBS1 IGFBP5 [inhibition] HSPA1A TSSK6 [inhibition] ESR2 SYNGAP1 [activation] CD19 IGHM [activation] HMGB1 CEBPB [activation] CDC42BPG SFN [activation] YES1 FLT1 [activation] MAPK8 SCOC [activation] NCF1 PAK1 [activation] NUTF2 NUP54 [activation] PDZRN3 MUSK [inhibition] SP1 CRK [activation] ILK RHOT2 [activation] CDK11B CASP3 [activation] RYR1 HOMER1 [activation] ESR1 SMARCA2 [activation] SOD1 SMAD2 [inhibition] APOB LRP6 [activation] GJB1 CAV1 [activation] AMOTL2 MYC [activation] PRKAA2 HOMEZ [inhibition] KIT PDGFRA [activation] GSK3B RELA [activation] GRB2 SMAD3 [activation] PIN1 FTSJ1 [activation] PPP2CA H2AFX [inhibition] SMAD3 C10orf118 [inhibition] FBXO25 EGFR [activation] RAB3IP RAB11A [activation] ARRB2 MLLT4 [activation] CCL24 CCR3 [activation] CDC25C HSP90AA1 [activation] MEIS1 HOXB13 [activation] CTNNB1 PTPRO [activation] RHOB NME2 [activation] VCAM1 HSPA8 [activation] POLR3D MAPK11 [activation] ERBB2 PTPRC [activation] ADRA2B GNAI2 [activation] PRKCQ HSF1 [activation] ACTR2 ACTR3 [activation] SRPK1 H2AFY [activation] PAG1 SHC1 [activation] MAPKAP1 RPS6 [activation] SUV39H1 CDC23 [activation] PRKCZ BTK [activation] TNF RNF31 [activation] PDS5A EGFR [activation] 页 21 共 454


2016/4/8 19:14

POLR1A NBN [activation] MMP2 SPOCK1 [inhibition] PRMT1 EIF4A3 [activation] SRGAP2 PPP2R1A [activation] PTGS2 ELAVL1 [activation] TEC PIP4K2A [activation] MAPK13 HIST1H1C [activation] ACVR1 TGFBR2 [activation;inhibition] ETS1 NCL [activation] PPP3CA RXRB [inhibition] ATR ATRIP [activation] GNB2L1 NR3C1 [activation] DAB1 TMTC3 [activation] GNAS LHCGR [activation] POLR2A CDKN1A [activation] CDK4 SETDB1 [activation] MCTS1 HLA-B [activation] ROCK1 HNRNPA1 [activation] CAMK1 SYN1 [activation] NXF1 PODXL [activation] IRF2 NFKB1 [activation] CLCN5 CFL1 [activation] NGFR MAGED1 [activation] SOX2 CTNNB1 [activation] TBX2 SUMO1 [activation] PCDH1 SMAD3 [activation] TRAF6 PLEKHO1 [activation] PACSIN2 PACSIN1 [activation] LCP2 TXK [activation] NR0B1 NR3C1 [activation] ANAPC1 SNW1 [activation] GAB2 TNFRSF11A [activation] SHC1 FCGR2B [activation] MAPK14 EEA1 [activation] RAB25 TGFBR1 [activation] ISG15 RAN [activation] CDKN2C REL [inhibition] UTS2B UTS2R [activation] E2F3 BCL6 [activation] ARFGAP1 RGS2 [activation] MAPK4 FASTKD5 [activation;inhibition] ZAP70 FYN [activation;inhibition] KIF23 BIRC6 [activation] LTK PIK3R1 [activation] GRB2 MAP4K5 [activation] MAPK11 MBP [activation] MGA E2F1 [activation] SRPK2 TRUB1 [activation] TRAF3 DDX58 [activation] PRKG1 BMPR2 [activation] CDC42 MYO6 [activation] GAPVD1 YWHAZ [activation] HSP90AA1 SGK223 [activation] THBS1 KNG1 [activation] CASP7 RAD21 [activation] TP53 PARD3 [activation] ITGA4 MCM2 [activation] NCK2 SRPK2 [activation] FLNA APC [inhibition] CRK MAP4K1 [activation] ABL1 CTAGE5 [activation] C9orf156 PTPRJ [activation] CTNNB1 FOXO1 [activation] MAP2K1 YAP1 [activation] GADD45G PTPRK [inhibition] BCL2L11 BCL2L1 [activation] HCLS1 ACTR2 [activation] PPP2R1A STK24 [activation] BUB3 APC [inhibition] CASQ2 ANKRD1 [activation] ABL1 SFN [activation] WHSC1 RANGAP1 [activation] ADAMTS12 CALM1 [activation] BAX VRK2 [activation] TEK GRB7 [activation] ANK3 CRKL [activation] 页 22 共 454


2016/4/8 19:14

NR4A1 PGBD1 [inhibition] INPP1 LIG1 [activation] VCAM1 IST1 [activation] SRPK1 SERF1A [activation] ILK ACACA [activation;inhibition] MARS MAP3K3 [activation] CTNNB1 STK39 [activation] CAB39L SRPK1 [activation] SREBF2 CASP8AP2 [activation] KPNA4 RAC1 [activation] ABL1 VPREB1 [activation] SRC DOCK1 [activation] APP AKAP1 [activation] ZC2HC1C SFN [activation] NFYB TP53 [activation] FCGR2B FYN [activation] IL15 STAT5B [activation] HNF1A KAT2B [activation] EP300 STAT1 [activation] TNFRSF1A RHOA [activation] SRSF5 PPARGC1A [activation] CDC42 BCR [activation] SMARCB1 GATA1 [activation] CTCF PYHIN1 [activation] SUV39H1 RB1 [activation] STX16 STX6 [activation] CYTH2 PRKCB [activation] STK3 GABARAPL1 [activation] PPP2R2B RAC1 [activation] ZFPM2 GATA1 [activation] MAST1 SNTA1 [activation] KMT2A MYB [activation] HNRNPA0 GADD45A [activation] LRRC29 KLHL40 [activation] SMAD4 AR [activation] MAPK14 EEF2K [activation] VCL VASP [activation] EGFR CCDC50 [activation] HMHA1 YWHAE [activation] YTHDC2 USP42 [activation] MMRN1 F5 [inhibition] CASP2 MDM2 [activation] MAST3 PPP6C [inhibition] LTBP3 TGFB1 [activation] CD247 PTPN6 [activation;inhibition] BRD4 TWIST1 [activation] APP GNRH2 [activation] TGM2 SRC [activation] COX17 PPBP [activation] NEK8 HSP90AA1 [activation] PPID HSF1 [activation] TBL3 ITSN2 [activation] TCF7L2 CTNNBIP1 [inhibition] YWHAB SRPK1 [activation] MET PTPRG [activation;inhibition] HABP2 KNG1 [inhibition] APP NIM1 [activation] IGF2BP1 VCAM1 [activation] SRC PRKACA [activation] ACTA1 CDH2 [activation] EP300 PRDM2 [activation] PTPN11 STAT5A [activation] PKM ENO3 [activation] RIPK2 PRMT2 [activation] SH3KBP1 RAB5A [activation] PAK3 ARHGEF7 [activation] PAXIP1 RAD50 [activation] HSPA4 GZMA [activation] HDAC3 SREBF2 [activation] MDC1 YWHAZ [activation] DDX5 PHLDA3 [activation] FGF5 MAPK1 [activation] PI4K2A NOS3 [activation] NUCKS1 DOCK9 [activation] PTPN12 KIT [activation] ACTB NOS2 [activation] 页 23 共 454


2016/4/8 19:14

WFS1 CFTR [activation] FAM9B CDC23 [activation] MXD1 CD2 [activation] CCDC8 EIF2S1 [activation] EIF3I TNFRSF14 [activation] ACVR2B ACVR1B [activation] NABP2 TP53 [activation] APC ANP32B [inhibition] PIP4K2A EPB41L3 [activation] CBLB TICAM1 [activation] IL2RB IL15RA [inhibition] HIST2H2AB EP300 [activation] PCDHA10 CRK [activation] TNK2 CDC42 [activation] EGFR EXOC3 [activation] GABARAP IGF2BP1 [activation] FGG ITGB3 [activation] CCDC115 PRKCZ [activation] FLI1 ELK1 [activation] CDK11A SKIV2L [activation] RHOH TGFBR1 [activation] STX1A ABCC9 [activation] STAT1 STAT5A [activation] GNAL USP3 [inhibition] BTK DAAM1 [activation] NR5A2 NCOA3 [activation] YWHAE IRS4 [activation] RPA3 PCF11 [activation] CALM1 STK11 [activation] PML RELA [activation] TMEM63B MAPK14 [activation] EEA1 IGF1R [activation] SIRT1 KAT2B [activation] CMBL H2AFX [activation] AURKA APP [activation] CAMLG IER3 [activation] ARFGEF1 NUP62 [activation] HSP90AB1 TP53RK [activation] FES ABI1 [activation] NDEL1 YWHAG [activation] CGA PTPN12 [activation] KPNB1 MYC [activation] PPP2R1B ESPL1 [inhibition] IQCB1 VAMP2 [activation] CTTN ESR2 [activation] FBP2 BUB1 [activation] GRIA2 PRKCA [activation] TRABD HIPK4 [activation] IL6ST SHC1 [activation] CCT3 ILK [activation] CASP7 PANX1 [activation] CUL1 HSPA8 [inhibition] EIF4E PPP2CA [inhibition] MDC1 PRKDC [activation] MAPK1 PRPSAP1 [inhibition] LCE1B OTX1 [activation] SRPK1 LBR [activation] FOS ARFGAP1 [activation] ABR ECT2 [activation] SRC ADAM17 [activation] MAP2K3 TINF2 [activation] PPP1CC PPP1R15A [inhibition] LAMC1 SRPK1 [activation] FNBP4 FYN [activation] UNC13B BARD1 [activation] FBXO6 PROS1 [inhibition] AURKA RAB10 [activation] CDK2 CCNE2 [activation] SSFA2 WNK1 [activation] GNAI1 ESR1 [activation] OS9 EGLN1 [activation] TMSB4X GRB7 [activation] BCAR3 ACTR2 [activation] CYFIP1 RAC1 [activation] WNK1 ARAF [activation] MAX CLIP2 [inhibition] 页 24 共 454


SRPK3 OPN1LW NUP93 BCL3 PAX6 HLA-B PIK3CA DFFA PRAP1 TCF7L2 FGF7 ILK CHMP4A FYN INSR LRP1 MAP3K7 CSF1R TSC22D1 APP CTTNBP2 MATK TCAP DNAJA1 ARPC2 TNF ITGA4 CBL GRB2 CDK2 DNTTIP2 C1QA FOS AURKA KPNA2 ANKS1B ESR1 RPS6KA5 EP300 APP TRAF3 CRLF1 CCND1 PAK1 ILK PTEN ATG7 TRAP1 HLA-B SMARCA4 TRAF6 GPSM1 YWHAE KPNB1 H3F3A PLG ACTG1 H2AFX AURKA TRAF5 TP53 PRNP LAT BCAR1 RPAP3 ATP13A2 ILK DDX47 EGFR CASP2 POT1 CFLAR MAGEC1 GCN1L1 CDK1 ARHGEF1

2016/4/8 19:14

RRP1B [activation] RANBP2 [activation] MYC [activation] CTNNB1 [activation] CDX2 [activation] GLRX3 [activation] FANCC [activation] YWHAB [activation] GRB2 [activation] PSEN1 [inhibition] UBQLN1 [activation] UNC45A [activation] F2R [activation] DNASE1L2 [activation] DOK5 [activation] YWHAG [activation] DARS [activation] IL34 [activation] MYO1B [activation] AURKB [activation] PPP2CA [inhibition] ERBB2 [activation] MYOZ2 [inhibition] TAB1 [inhibition] ARPIN [activation] NT5DC3 [activation] SCRIB [activation] CDKL2 [activation] SNRNP200 [activation] POLL [activation] RXRA [inhibition] COL2A1 [activation] SUPT6H [activation] MTA3 [activation] CTCF [activation] HTR2A [activation] RDX [activation] PDLIM1 [activation] MRE11A [activation] ASPSCR1 [activation] CFLAR [inhibition] CNTFR [activation] FANCC [activation] GIT1 [activation] SDF4 [activation] ANG [activation] SLX4 [activation] CEP250 [activation] SUPT16H [activation] ATF3 [activation] PREP [activation] CUL3 [inhibition] MLLT4 [activation] NOTCH1 [activation] RNF41 [activation] LAMA5 [activation;inhibition] EZH2 [activation] CFL1 [activation] IK [activation] RIPK2 [activation] RRP1B [activation] FGF13 [activation] EGFR [activation] SH2D3C [activation] DPCD [activation;inhibition] COL1A1 [activation] ABCE1 [activation] MLH1 [activation] SH2B1 [activation] BID [activation] AIM2 [activation] IKBKB [inhibition] ROCK2 [activation] FBXO6 [inhibition] CDKN1B [activation;inhibition] SREBF2 [activation] 页 25 共 454


2016/4/8 19:14

IFNA1 CR2 [activation] IKBKB CREBBP [activation] FAS PRKCA [activation] CCDC102B CCHCR1 [activation] PLCB1 TRPM7 [activation] BARD1 CPSF3 [activation] PCNA BARD1 [activation] KIR2DL4 HLA-G [activation] RPS6KA1 L1CAM [activation] TWF1 BTK [activation] NCKAP1 CYFIP2 [inhibition] CCHCR1 NUP62 [activation] EXOC1 TRIO [activation] ENO2 AKT1 [activation] KLHL1 CACNA1A [inhibition] NCK1 DRD3 [activation] RYR1 TTN [activation] INSR CYTH2 [activation] PPFIBP1 TP53 [activation] GP1BA GP9 [activation] NOS3 A2M [inhibition] MAP3K14 HSPA6 [activation] SFN EIF2S1 [activation] AKT2 SLC2A4 [activation] FBXW7 MAP2K1 [activation] EZH2 XPO1 [activation] TRADD DAB2IP [activation] MAD2L1 MAD2L1BP [inhibition] SOCS1 CUL2 [inhibition] APBB2 EGFR [activation] GABARAPL2 PTPRA [activation] CCDC8 CXADR [activation] DLX2 PIK3R1 [activation] JAG1 MLLT4 [activation] LRRK2 YWHAE [activation] YTHDF2 RPA1 [activation] CRK PCDHA7 [activation] TP53 STAT6 [activation] NXF1 FAM83G [activation] GOLGA2 NDEL1 [activation] CDC16 MDC1 [activation] EVL CRKL [activation] IBTK CD81 [activation] CDKN2A SERTAD1 [activation;inhibition] PLXNB2 MST1R [activation] CFTR DNAJB1 [inhibition] BRI3BP TRAF6 [activation] JAK3 SH2B2 [activation] CYCS GSTK1 [activation] RPA1 RPS6KA5 [activation] RET PTK2 [activation;inhibition] IK GRB2 [activation] MTOR SUMO1 [activation] RYR1 NCK1 [activation] TSC22D4 PRKAA1 [inhibition] BID CSNK1E [activation] TNFRSF1B MAD2L1 [inhibition] GRIA2 DLG4 [activation] IL5 IL8 [activation] TRAF1 TRAF3 [activation] TRAF6 ARPC2 [activation] HLA-G HLA-A [activation] SDCBP EPHB2 [activation] CD44 SCYL3 [activation] MCM7 CCNH [activation] MAST1 YWHAZ [activation] BARD1 TRAPPC11 [activation] LRP1 NOTCH3 [activation] PPP2CA CCNG2 [inhibition] CREM SPI1 [inhibition] ARHGDIA SUMO4 [activation] SH2D2A EGFR [activation] MDM2 NPM3 [activation] UBE2E3 DET1 [activation] SUMO4 PRDX3 [activation;inhibition] ZNHIT3 ESR2 [activation] 页 26 共 454


2016/4/8 19:14

ADRB2 RNF41 [activation] SMAD2 CDK4 [inhibition] WHSC1 RAD50 [activation] PPP2CA TLX1 [activation] PKM ANXA7 [activation] SNAI1 MAPK1 [activation;inhibition] SOS1 PTPN6 [activation;inhibition] AGK ICT1 [activation] FYN GCFC2 [activation] EPRS EGFR [activation] CA4 SLC4A3 [activation] MYL12B HSPB1 [activation] PTEN PPP2R4 [activation] PRKACA LCP1 [activation] POMGNT2 NOTCH2NL [activation] FAM13B WNK1 [activation] GSK3B PRKCB [inhibition] SH2D1A SLAMF7 [activation] DNER PSEN1 [activation] PIK3CA ITIH1 [activation] RHOJ WAS [activation] MDM4 BCL2 [activation;inhibition] PPP2CA ARL2 [inhibition] NEK3 VAV2 [activation] ANAPC7 HSPB1 [activation] DDX24 GABARAPL2 [activation] HIF1A SAT2 [activation] CIT RHOA [activation] SRC ENO1 [activation] SRPK1 SETD3 [activation] RELA MAP3K7 [activation] ACD SBDS [activation] PXN BCR [activation] CAMK2A DLG1 [activation] GRB2 UBA1 [activation] EIF4EBP1 REL [inhibition] BCL3 NFKB2 [activation] AR PXN [activation] NME3 JAM2 [activation] BAG1 HBEGF [activation] IRF3 BAX [inhibition] FLI1 GATA1 [activation] NCK2 ERBB3 [activation] SORCS2 NGF [activation] FOS HSP90B1 [activation] F8 MAP1LC3A [activation] PTPRJ GAB1 [activation] HDGF RAN [activation] EIF4G1 TRAF6 [activation] FDX1 CYP11A1 [activation] CAMP ELANE [activation] STK35 TGFBR1 [activation] COX4I2 CYCS [inhibition] GTF2B RELA [activation] ANXA7 GDF9 [activation] EP300 SERTAD1 [activation] PTEN CAV1 [activation] MPL ATXN2L [inhibition] SMYD3 CAMK2B [activation] ERBB3 DAPP1 [activation] CRLF2 JAK2 [activation] WDR26 EGFR [activation] STAT3 STMN1 [activation] GNB5 MVD [activation] VAPB ASNA1 [activation] HPS6 CREB1 [activation] PPP2R1A DOCK5 [inhibition] PRKDC NOTCH1 [activation] PRNP ZNF408 [activation] FAS CTNNB1 [inhibition] NCAM1 MDK [activation] MAP1LC3B STK4 [activation] STRN4 GDF9 [activation] YWHAB BAIAP2 [activation] APBB1 LRP1 [activation] PGAM5 ESR1 [activation] 页 27 共 454


2016/4/8 19:14

FOSL1 TRIM24 [activation] PDGFRL CTSV [activation;inhibition] EFHC2 ARHGEF5 [activation] SNW1 ILK [activation] DYRK1A TROAP [activation] RAB1A CAPNS1 [activation] CNTFR PLSCR1 [activation] BHLHE41 CEBPB [activation] SHC3 ALK [activation] KAT2A NOTCH1 [activation] GRB2 HDGFRP3 [activation] EIF4E EIF4G3 [inhibition] EGFR PRCC [activation] SIM2 HSP90AB1 [activation] PML IER3 [activation] CDK3 E2F3 [activation;inhibition] CASP8 NR1H4 [inhibition] MAP4K1 FYN [activation] ESR1 HSPA1L [activation] CSNK1D BACE1 [activation] SERPINB4 RASSF9 [inhibition] STRN4 PPP2R1A [inhibition] MAP3K2 WNK1 [activation] ERP44 ITPR1 [inhibition] MMP8 TIMP2 [activation] EXOC7 EXOC4 [activation] APP CDKN2D [inhibition] IRS1 YWHAH [activation] CTNNB1 EP400 [activation] ESR2 PRKDC [activation] VCAM1 PRDX3 [activation] HSP90AB1 TRAF2 [activation] EP300 APEX1 [activation] RAD21 TNFRSF14 [activation] NLK TNKS1BP1 [activation] FYN FRK [activation] CHRNA7 APP [activation] WDR48 STK11 [activation] RPA3 BUB3 [activation] CALM1 ARRB2 [activation] CASK ARHGEF7 [activation] RARA STAT5B [activation] ICK CD247 [activation] PALB2 HNRNPC [activation] CD4 PIK3R1 [activation] HMGB1 SOX18 [activation] FRS2 PTPN11 [activation] GRB2 KIRREL [activation] PPP1R2 LMTK2 [activation] FOXP1 IL3RA [activation] RASA1 PTK2B [activation] SRPK2 ADAP1 [activation] ADD1 CASP3 [activation] SHC1 GEMIN7 [activation] TENC1 FGFR1 [activation] KIT TENC1 [activation] GNAI1 WASF1 [activation] INSR SMAD2 [activation] TP53 GTF2I [activation] KPNB1 NRIP1 [activation] IKBKB CSF2RA [activation] MYC MARS [activation] TGIF1 MAPK1 [inhibition] DNAJB1 SOD1 [inhibition] BMPR2 CCDC89 [activation] RAC1 VAV3 [activation] SOCS3 RASA1 [activation] VAV1 FGFR1 [activation] CREBBP RPS6KA2 [activation] TNIP2 STK11 [activation] STAT3 BCKDK [activation] PRIM1 CIAO1 [activation] NCAM1 ST8SIA3 [activation] EIF3J EIF4G2 [activation] SDCBP UBE2A [inhibition] VRK2 TP53 [activation] 页 28 共 454


2016/4/8 19:14

USP9X CASP4 [activation] MAPK3 IER3 [activation] ITGB3 ITGAV [activation] CCND3 MAPK4 [inhibition] CACNA2D2 USP2 [inhibition] EPHA2 NUDT9 [activation] SH3BP1 RHOA [activation] AR CTNNBIP1 [inhibition] AURKB AURKA [activation] CD4 HNRNPD [activation] RAN NXT1 [activation] HIPK4 AFG3L2 [activation] BMP4 WFIKKN2 [activation] MAPK6 WDR34 [activation;inhibition] CTRB1 SERPINF2 [activation] PGK1 PYHIN1 [activation] TRMT2A RASA1 [activation] MAP1LC3A HSPA2 [activation] DUSP3 ZAP70 [inhibition] FOXP3 KAT8 [activation] EGFR HIST3H3 [activation] SGK2 CCT8 [activation] YY1 ATF2 [activation] FAM193B MAPK8 [activation] NAT10 ITGA4 [activation] CEP250 CRTC2 [activation] MAP2K7 TRAF6 [activation] UBL7 CD4 [activation] RELA AR [activation] ANXA7 SEMA5B [activation] RAD18 MAPK8 [activation] PRMT1 YWHAG [activation] PTPLAD1 GRB2 [activation] LTA TUBA1B [activation] PRKAA1 NUAK2 [inhibition] APP MS4A2 [activation] F13A1 F13B [activation] PMAIP1 BAX [inhibition] KAT2B TRRAP [activation] MT-RNR2 BAK1 [activation;inhibition] DVL3 TNFAIP8L1 [activation] MAPK8 C11orf57 [activation] BIRC3 RIPK4 [activation] HIST1H1A CCNE1 [activation] JUNB BRCA1 [activation] PTPN12 EGFR [activation] APP NME3 [activation] CHGB FGFR3 [activation] HP1BP3 WHSC1 [activation] SMURF1 NUMA1 [inhibition] USP8 RASGRF1 [activation] PRKACA VAPA [activation] FASLG RHOA [activation] MAPK1 MCL1 [activation] STK4 ARHGAP1 [activation] CYP11A1 SMAD3 [activation] MYF5 MDFI [activation] CBL FCGR1A [activation] RIT1 RALGDS [activation] UBE2A PCNA [inhibition] CTAGE5 RASAL2 [inhibition] LATS1 CDK1 [inhibition] CHUK CREBBP [activation] E2F1 NPDC1 [activation] RASGRP3 PRKCD [activation] RARA PML [activation] SRPK3 KRR1 [activation] HSP90AA1 MAST2 [activation] VCAM1 CHMP2A [activation] ARHGAP10 RHOA [activation] STK11 TUBB4A [activation] INHBB ACVR1C [activation] STX17 KRAS [activation] PIK3CA NEDD9 [activation] PCNA FTSJ1 [activation] CYP4Z2P GABARAPL1 [activation] 页 29 共 454


2016/4/8 19:14

KCNA4 KCNAB2 [activation] WASL EVL [activation] CRYAB CASP6 [activation] TLR4 SIGIRR [activation] PDCD6IP UBA5 [activation] TRAPPC5 EGFR [activation] VAMP3 ATP4A [activation] G3BP1 VCAM1 [activation] PLP2 CCR1 [activation] ABI3 SNAP23 [activation] FANCE FAAP20 [activation] SPRR2A SRC [activation] GSK3B GRB14 [activation] HDAC1 LEF1 [inhibition] NXF1 TNFRSF11A [activation] ARHGDIA TNFRSF1A [activation] MAPK10 CDKN1B [inhibition] PIK3R1 ERBB3 [activation] BDNF CADPS2 [activation] RPS6KB1 TERT [activation] BECN1 DAPK1 [activation] AURKA SRPK1 [activation] SMAD2 RASD2 [activation] GNB2L1 CD81 [activation] PFN1 MLLT4 [activation] RANBP9 OPRM1 [activation] CREB1 NR3C1 [activation] NXF1 NTN4 [activation] UBE2I SEMA6A [activation] NFE2L2 YY1 [activation] TP53BP1 KPNB1 [activation] KIAA1683 CALM1 [activation] CSNK2A2 SPP1 [activation] CRTC2 NEDD1 [activation] MAPK9 XPO7 [activation] APOC1 VKORC1 [inhibition] HSP90AA1 BTK [activation] CASP7 CASP6 [activation] MYD88 USP7 [activation] CDK6 SIRT1 [inhibition] RYR2 RYR1 [activation] ERBB2 PTK6 [activation] STAT3 DAPK3 [activation] SARG SMAD3 [activation] HOMER1 ABI3 [activation] CWC15 PRNP [activation] BLK HSP90B1 [activation] STK24 CASP8 [activation] FBXO6 NUP214 [activation] NXF1 RAD51 [activation] PARP1 MRE11A [activation] SEMA7A NCK1 [activation] CSNK2B RPS6KA1 [activation] PASK MAPT [activation] MAP2K5 PARD6A [activation] YWHAZ LRRK2 [activation] ESR1 RAN [activation] RNF114 UBE2W [activation] HEATR4 ESR2 [activation] CXorf27 CEP44 [activation;inhibition] SNAP23 PRKCA [activation] FER ABI1 [activation;inhibition] DAOA DAO [activation] MAG APP [activation] CHD4 NOTCH1 [activation] EDA2R C1QB [activation] ICT1 RPUSD3 [activation] RHEBL1 SMAD1 [activation] MDN1 NOTCH1 [activation] SUMO4 DNAJA1 [inhibition] S1PR2 S1PR1 [activation] SDCBP MAD2L1 [inhibition] FANCA CRK [activation] MBP SRPK1 [activation] CPLX1 VAMP2 [activation] YKT6 BAG3 [activation] 页 30 共 454


2016/4/8 19:14

ARF6 HYOU1 [activation] MAPK3 TRIM54 [activation] GAS2L3 AURKB [activation] MDM2 FASN [activation] TRPC3 STX3 [activation] BEX1 CHEK2 [activation] EXT2 CNTF [activation] SRSF6 MDM2 [activation] RAP1GDS1 RAC1 [activation] NTRK3 TNK2 [activation] STAT6 ANXA2 [activation] GRB2 SMARCA5 [activation] RASSF10 ANXA1 [activation] DDX39B CHTOP [activation] CHEK1 HSP90AA1 [activation] MYC BRD3 [activation] CDKN1A HSPA5 [inhibition] HIST1H2BD ICAM1 [activation] CASP3 ATN1 [activation] TNK2 PTPRJ [activation] BCL2L11 MAGEA11 [activation] YWHAQ CRK [activation] SMAD2 SARG [activation] MAP1LC3A NUP214 [activation] ERH IGSF21 [activation] ITGA4 PIK3R2 [activation] GRB2 GAREM [activation] AURKA EPSTI1 [activation] PPARA AIP [inhibition] GRIA2 GTF3C2 [activation] CDC25B PGR [activation] AMOTL1 NXF1 [activation] TP53 NR0B2 [activation] CREM CDK1 [inhibition] MAPRE1 MAPRE2 [activation] SMC2 CASP4 [activation] CRK PTK2 [activation] UNC13B STX1A [activation] NSUN4 ICT1 [activation] YWHAZ SLC8A2 [activation] HLA-A GNAS [activation] CUL1 PTTG1 [inhibition] CNTNAP1 RHOA [activation] SPIB E2F1 [activation] RPA2 RAD50 [activation] PTPRJ CSK [activation] VCAM1 DHX30 [activation] LDLRAD1 PLN [inhibition] SUMO1 E2F1 [activation] CDC42EP4 SRPK1 [activation] SRSF6 YWHAG [activation] YWHAH SRGAP2 [activation] ITGA4 HIST1H1B [activation] GRB2 SLC25A6 [activation] RXRA CNOT1 [inhibition] MYC IK [activation] PIP5K1A PLD1 [activation] MCF2L AIMP2 [activation] RAN MAPK13 [activation] DYRK1A FAM117A [activation] SCRIB APC [activation] FZD5 RPS6KA6 [activation] CNTNAP1 KCNA2 [activation] FBXO5 SRC [activation] EIF4EBP1 MVD [activation] RAD51D C1orf94 [activation] CREBBP EP300 [activation] HCK FASLG [activation] TPD52L2 TPD52L1 [activation;inhibition] HSPA8 CDC20 [inhibition] ARHGAP5 PTK2B [activation] MAPK6 ACTG1 [activation] RPLP2 GRB2 [activation] CASP7 RAD51 [activation] ITGA4 PTPN23 [activation] NF1 PML [activation] 页 31 共 454


2016/4/8 19:14

BTK POTEKP [activation] PTPN6 G6B [activation;inhibition] YAP1 CTNND1 [activation] SOCS2 TPD52 [inhibition] EIF4A1 TRAP1 [activation] SHC1 CORO1C [activation] STAT5B PPP2CA [activation] PYHIN1 SDC1 [activation] HIST1H1C PRKDC [activation] EP300 HNF1A [activation] JUP FYN [activation] EPB41L4A SRPK2 [activation] RPA1 PRKDC [activation] EBLN2 CAB39 [activation] APP SIGIRR [activation] CRK CDH11 [activation] HIST1H2BA ICAM1 [activation] HSP90AA1 ACTG1 [activation] ERBB2 VAV3 [activation] PRKACA TNP2 [activation] RAP1A HDAC1 [activation] EEF2 MAPKAPK3 [activation] MDM2 OGDHL [activation] YWHAZ SLC9A1 [activation] RAD23B ETS1 [activation] E2F1 KAT2A [activation] ATG5 P4HB [activation] TRAF6 ERH [activation] APP MAPKAPK3 [activation] ZBTB17 UBE2H [activation] DDX52 OBSL1 [activation] CYFIP1 YWHAG [inhibition] NR1I2 MAPK7 [activation] UBC RAD51C [activation] WBP2 WWTR1 [activation] PTGS2 TP53 [activation] TRIP6 PDGFRB [activation] RANBP1 FTSJ1 [activation] PARP1 IKBKB [activation] PLCB2 TBXA2R [inhibition] MDM2 ETFB [activation] LRRK2 TUBB [activation] SRC ROR1 [activation] PPP2CA DOCK5 [inhibition] DOK1 ITGB3 [activation] MET SH3BP2 [activation] EPB41L3 EIF2B2 [activation] RIF1 LAMA4 [activation] OBSL1 HMGA2 [activation] IKZF1 GATA1 [activation] RIMS4 APP [activation] SREBF2 PIAS2 [activation] CDKN2A CDKN2AIP [activation;inhibition] PIK3CG CD37 [activation] ENO1 NUDC [activation] MYC CACNA1G [activation] TAF1 UBTF [activation] UTP18 VCAM1 [activation] GSK3B QARS [inhibition] TUBA1A LTA [activation] ZNF106 MYC [activation] DIAPH3 RAC1 [activation] CNKSR1 RHOH [activation] FAM107A LRRK2 [activation] CAPZB DAPK1 [activation] RPA1 FBXO18 [activation] RNF8 UBE2E3 [activation] ZIC2 GLI2 [activation] NR3C1 SFN [activation] CASP3 TXN [activation] PRKCA GRM1 [activation] MAVS TRAF6 [activation] SMAD9 KMT2D [activation] PML LRRK2 [activation] DNAJA2 GRB2 [activation] HNRNPA0 DDX5 [activation] 页 32 共 454


PSMG1 PPP2R2B NUDC HSPA2 SMAD4 MAPK1 RPA3 FUT9 CASP8 ANKRD52 APP PVRL1 PAXIP1 TP53 BCL3 VCAM1 PER3 VDAC1 GNAQ OBSL1 DAB1 OPALIN APP MAFG PIAS1 AIRE BLK BEX1 NF1 MIA SMURF1 IGF1R NCKAP1 HMGA1 SFN BIRC2 TOLLIP NUDC TLN1 PIK3R2 DDR1 MAPT NBN ICT1 DAZAP2 RHO A2M CTBP1 EEA1 YWHAZ CCNT2 NSD1 TWF2 FOS APC DDX56 CNTNAP4 F12 IKBKB MCM7 SYNGAP1 IL1B HELLS NCOA2 CYP11B2 MAPK3 RB1 BCL2L1 ETS1 BARD1 ATP6AP2 POLR2C PAM ACTG1 F2RL2 CXCL1

2016/4/8 19:14

LRRK2 [activation] PDPK1 [activation] WRAP73 [activation] SCHIP1 [activation] RHOJ [activation] EPOR [activation;inhibition] AHNAK [activation] TSSK3 [activation] BLID [inhibition] PPP6C [inhibition] PTGER2 [activation] PRNP [activation] TM2D3 [activation] PPP1R13B [activation] TBP [activation] BLVRB [activation] PER2 [inhibition] ICT1 [inhibition] GRM2 [activation] BAZ1B [activation] KRTAP19-7 [activation] CALM1 [activation] CCDC115 [activation] PAX6 [activation] JUN [inhibition] RANBP2 [activation] BCR [activation] PIK3CA [activation] APP [activation] FASLG [activation] SMAD2 [inhibition] LEF1 [activation] MYO16 [inhibition] RXRA [inhibition] EIF4B [activation] ABHD17A [activation;inhibition] CSN1S1 [activation] TIMP2 [activation] CDK5 [activation] SHC1 [activation] COL5A2 [activation] EP300 [activation] MRE11A [activation] C6orf203 [activation] ZFYVE9 [activation] GRK6 [activation;inhibition] CPB2 [inhibition] EGFR [activation] STX6 [activation] DKC1 [activation] BRD4 [activation] ESRRA [activation] IQCB1 [activation] SIRT1 [activation] PRKACA [activation] TBC1D4 [activation] TIAM1 [activation] MMP12 [activation] TRIM40 [activation] UTP18 [activation] DLG3 [activation] IKBKG [activation] LRRK2 [activation] ESR2 [activation] CYP11A1 [activation] MAP3K14 [activation;inhibition] HSPA8 [inhibition] MAPK8 [activation] MAPK1 [activation] PPM1G [activation] USP20 [activation] FGF3 [activation] POMC [activation] GZMA [activation] PLCG1 [activation] HRAS [activation] 页 33 共 454


2016/4/8 19:14

HBEGF MMP7 [activation] ULBP1 RAET1G [activation] RAD9A MLH1 [activation] IGKC CAV1 [activation] HSPB1 CCDC64 [activation] RPS6KA5 SMARCA4 [activation] SMAD2 PREX2 [activation] GGCX F7 [activation] MAPK14 SUPT20H [activation] PLG F2RL1 [activation] TRAF6 TNFRSF17 [activation] EIF2AK2 CCNA2 [activation] ZFYVE28 PRNP [activation] ESR2 PREPL [activation] MLLT4 YWHAH [activation] SLX4 UBA5 [activation] MAP2K5 ENO1 [activation] IGHM PTK2 [activation] GABARAP YTHDC2 [activation] VCL GSN [activation] MAPK8 DUSP22 [inhibition] MAPKAPK5 CDCA8 [activation] ANAPC7 TP53BP1 [activation] ICAM1 EIF3L [activation] CAV1 NTRK1 [activation] CTNNA1 NFKBIA [activation] GRB2 MCC [activation] ESR1 ACTR2 [activation] HLA-B MTPN [activation] UNC13B ECT2 [activation] THRB NRIP1 [activation] HLA-B TRMT112 [activation] AKAP8 CASP3 [activation] MYL12A MAP3K3 [activation] ABL2 GPX1 [activation] KIF17 C16orf70 [activation] GABRR1 MYC [activation] RAF1 FYN [activation] HIF1A DAP3 [activation] APP APITD1 [activation] ZRANB1 APC [inhibition] GNB2L1 IFNAR1 [activation] NPB NPBWR2 [activation] TOLLIP TLR9 [activation] YWHAB MTMR12 [activation] LTB4R2 AKT1 [activation] PREX2 MTOR [activation] TRIM28 ITGA4 [activation] TAOK3 TRAF2 [activation] XKRX MYC [activation] CDC5L UBE2N [activation] EGFR DOCK4 [activation] MAD2L1 ESR2 [activation] CDK1 HSPA4 [activation] PTPRB PDPK1 [activation] RPS6KA5 PLA2G4A [activation] HSP90AB1 TP63 [activation] GRB2 KRT17 [activation] RAD54B UBE2I [activation] RAMP1 IAPP [activation] DAG1 CSK [activation] TRIM28 CHEK2 [activation] OR6B3 SRPK1 [activation] PIGK ULBP2 [activation] ATR PTS [activation] NUDCD3 KLHDC8A [activation] WAS PTPN12 [activation] HSPB1 HSP90AB1 [activation] PRKDC FBXO6 [inhibition] GBP2 ANXA7 [activation] FYB PIK3R1 [activation] FTSJ1 SARS [activation] CD3E TOP2B [activation] JAK2 MAP3K5 [activation] APC AGR3 [inhibition] NFATC1 JAK3 [activation] 页 34 共 454


2016/4/8 19:14

YWHAG VCAM1 [activation] XPA MLH1 [activation] WHSC1 HNRNPL [activation] SEMA3A SUMO1 [activation] TNFRSF1A CSNK1A1L [activation] YWHAE GRAP2 [activation] IGF2BP1 CDKN1A [activation] MCM7 JUP [activation] TRAF5 TRAF2 [activation] CASP9 MAP2K2 [activation] SHH PTCH2 [inhibition] SMARCB1 SRC [activation] NEDD1 IRS4 [activation] BIK CRKL [activation] RASAL3 YWHAE [activation] GRB2 PTPRT [activation] PSEN2 CASP6 [activation] MAP4K3 SH3GL2 [activation] EP300 KLF1 [activation] TMCO3 EGFR [activation] NXF1 GRN [activation] LGR4 ACTB [activation] EP300 PAX5 [activation] GABARAP TIAL1 [activation] MAP1B SPP1 [activation] MAP3K8 CD40 [activation] APP DDX18 [activation] KPNA3 GATA6 [activation] GIT1 PLCG1 [activation] USF1 PPP1CC [activation] SMO BCL6 [inhibition] HSP90AB1 CAMKK1 [activation] PRKCB DVL2 [activation] DACH1 SIX1 [activation] SWSAP1 RAD51B [activation] ACACA EGFR [activation;inhibition] LIG1 MRE11A [activation] CASP4 PLA2G4A [activation] PCK1 FASN [activation] FOS CYTH4 [activation] PAK1 PAK1IP1 [activation] PTP4A1 CREB3L2 [activation] MDM2 C19orf10 [activation] CARM1 TP53 [activation] TSC1 NF2 [activation;inhibition] ARHGEF6 SMAD3 [activation] YWHAZ OBSL1 [activation] TCP10 PARD6A [activation] NEDD4L CACNB1 [inhibition] MAP2K7 HSP90AB1 [activation] PDCD6 KDR [activation] SMAD7 SKP2 [activation] UBE2D1 CBL [inhibition] MPP2 ERBB2IP [inhibition] SMARCB1 MYC [activation] CD302 BCL2L11 [activation] WDR61 KMT2A [activation] CAT ABL2 [activation] YWHAE EIF4E2 [inhibition] FAM117B SFN [activation] CDH2 PTPRR [activation] BAG3 GNAI3 [activation;inhibition] NAMPT IFITM3 [activation] PAX8 TMA16 [activation] CSNK2B NFKBIA [activation] STK4 HSPA7 [activation] EURL GRB2 [activation] HSPA2 NOS2 [activation] NCLN ARF6 [activation] ERBB2 C9orf156 [activation;inhibition] CASP3 HMGB1 [activation] HABP4 SRSF9 [activation] SH3RF3 PAK2 [activation] CAV1 LRP1 [activation] NPBWR1 NPW [activation] MDM4 SMAD3 [inhibition] 页 35 共 454


KLK6 FGB LY6E CD247 ARNT2 USHBP1 DIAPH1 XPO6 RPTOR PIH1D1 DLG2 FZD7 IRAK1 HIST3H3 PIK3CB MME PTK2B NEDD9 GRB2 S100A6 CASK IL18 CAMKK1 CAMK1 MDM2 EP300 STAU1 SRPK3 HSPD1 EGFR SHANK3 SRC PALB2 MORF4L1 RPS6KA5 EGF ZSCAN9 SRPK2 DARS GRB2 ANKRA2 MPL TP53 CEBPB HSPB1 EIF1AX CTBP2 EP300 TP53 TUBG1 E2F3 MRP63 PTK2 APP NCAPD2 SMC4 NGLY1 EGFR MMP9 MMP26 NCOA3 NKX2-1 FYN MAPT TNFRSF10B KIF2A MYB PCM1 VCAM1 NUDT14 RAF1 KCTD12 RIPK2 CD22 PIK3R1 YAP1 RAE1 HSP90AB1 PPARG PPM1B NRP1 FGF7 PPP6R2 PLK1 PIK3R1 TEC OPRM1 DOK4 PAK6 TPD52L1 H2AFX A2M ITGA4 CD82 STAT3 GADD45A CD40 ERP44 ANXA2 PAK2 CDC25C YWHAE PALB2 MRC2 PFKFB4 GADD45A INSIG2 LGALS7 RAD52 HSPA4 VAV1 MET PPARG NR3C1 GTF2A2 GTF2A1 FOSL1 ATF4 EPHA3 ADAM10 HNRNPD MAP2K1 RAD21 TRAIP RANBP2 CTNNB1 CDC37 ULK1 MBP IKBKE CTNNB1 HERC5 HSPB1 CFTR CCHCR1 CTAGE5 ATF2 RAB11A YWHAG MSL2 PLK1 FBXO6 ADCY6 CHRNA7 MRE11A CCNE1 KCNJ4 GNGT2 SHC1 VAV1

2016/4/8 19:14

[activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] ITCH [activation] [activation] [activation] [activation] [activation] [activation] [activation] CDK15 [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 36 共 454


EGFR FLNC GLMN MEF2A CASQ2 PDX1 EIF4A2 RPS6KA5 NUDT5 RICTOR EGLN3 NOS3 EBI3 PRNP NCKIPSD PTPMT1 NCOA1 BCR VCL PHKG2 STAT2 RAPGEF2 TRAF2 BCL7C ATM SHB HSPB1 TSPAN6 ABL2 PPP2R5B PTPN1 YWHAB GNB5 VCAM1 EIF2B1 MDM2 CCR1 TUBB ABL2 TRAF6 STAT3 PLCG2 TCOF1 FANCG SMAD3 NOP2 RPS24 MYC GAB1 STAT3 PIAS1 AATK ITGB1 RPL11 DERL1 PPP2CA VAPA TRAK2 PRKAA2 AGTRAP DDX39B ADCYAP1 ITGA5 MALT1 CTDP1 PRKACA VDR TOP2B ASH1L ABL1 HSPA4 TLX3 FSHB PPP2R2A FZR1 EXOC5

2016/4/8 19:14

FAR1 [activation] GRB2 [activation] TMEM173 [activation] GNB2 [activation] CSNK2A1 [activation] PBX1 [activation] EIF4G3 [activation] SMARCB1 [activation] FTSJ1 [activation] TELO2 [activation] FOXJ2 [activation] APP [activation] MDFI [activation] DYRK3 [activation] CRK [activation] TAB1 [inhibition] NCOA2 [activation] YWHAZ [activation] LPXN [activation] GCN1L1 [activation] CREBBP [activation] MOB4 [activation] CASP1 [activation] EPAS1 [activation] XPA [activation] KIT [activation] ASB10 [activation] DDX58 [activation] JAK1 [activation] CHEK2 [activation] AGR3 [activation] HSPB1 [activation] E2F2 [activation;inhibition] RAC2 [activation] ARHGDIA [activation] RAB8A [activation] CCL3L1 [activation] RIPK1 [activation] PIK3R1 [activation] CSNK1G1 [activation] KPNA1 [activation] ZNF512B [activation] CDK2 [activation] FAAP100 [activation] PARD3 [activation] EIF2AK2 [activation] STK17B [activation] ZZEF1 [activation] FES [activation] FGFR3 [activation] SNIP1 [inhibition] CDK5R1 [activation] ITGA6 [activation] IGF1R [activation] PTGS2 [activation] DVL3 [activation] ERBB2 [activation] KCNJ2 [activation] KIFC3 [activation] HARS2 [activation] ITGA4 [activation] VIPR2 [activation] EGFR [activation] DIABLO [activation] E2F1 [activation] PRKACB [activation] TRIM24 [activation] TP53 [activation] SMAD7 [activation] NKX2-1 [activation] PRKAA1 [inhibition] SNTA1 [activation] CGB [activation] CHEK2 [activation] VHL [inhibition] CCDC102B [inhibition] 页 37 共 454


2016/4/8 19:14

REL CTNNBIP1 [inhibition] LSP1 KLK6 [activation] SRSF5 SMAD2 [activation] ACTB CPNE4 [activation] RGS17 LCE4A [activation;inhibition] SLX4 NUP153 [activation] ERBB3 ABL2 [activation] NR5A1 CRK [activation] KLKB1 HGF [activation] LEF1 VDR [activation] CRKL PPFIBP2 [activation] LARP1 SRPK1 [activation] EGFR ATP1B1 [activation] ITGA4 CFL1 [activation] RB1 PAX6 [activation] ERBB2 BTC [activation] SMARCA4 CHD7 [activation] KCNQ1 GRB2 [activation] TGFBR2 IQGAP1 [inhibition] RPA2 MDC1 [activation] GNL3 PHLDA3 [activation] PTPN1 GRB2 [activation] RARA MAPK1 [activation] BCL3 LCK [activation] RUNX1 WWTR1 [activation] EIF2AK2 KCTD17 [activation] OR10J1 TRAF6 [activation] EPHA2 TIAM1 [activation] HNRNPA1 GABARAPL2 [activation] CUL1 DUSP1 [inhibition] CAMK2A CHAT [activation] TNFRSF10D NUDC [activation] EGFR DDX20 [activation] ACTA1 BTK [activation] RPA3 MCM2 [activation] TRAF2 CASP12 [activation] JUN FBXL12 [activation] SMAP2 DAB1 [activation] BAALC CHEK2 [activation] RAD51C HELQ [activation] GKAP1 SOX18 [activation] TP53 ZHX1 [activation] RC3H1 TNF [activation] LAPTM5 DISP1 [activation] CDC5L ATR [activation] CREB3L2 PXN [activation] AVPI1 APP [inhibition] MAPK9 ARRB2 [activation] MAP4K2 DEFB1 [activation] NR1H2 NRIP1 [activation] DAAM1 DVL2 [activation] TWF2 CAPZA2 [activation] OBSL1 NUP62 [activation] ASB12 PFN1 [activation] TUBB4A LIG1 [activation] SMURF1 RIT1 [inhibition] RASSF9 DVL1 [activation] ANKS1A EPHA8 [activation] CALB1 CASP3 [activation] GABARAPL1 HSPB1 [activation] EPS8L3 ABI1 [activation] PACSIN1 ANKRD24 [activation;inhibition] IRX4 RARA [activation] USHBP1 C1orf216 [activation] HSPA1A TCERG1 [inhibition] XIAP E2F1 [activation] ACTA1 VCL [activation] TBC1D1 BARD1 [activation] EGLN3 MAPK7 [activation] CNKSR1 CADM4 [activation] YTHDF1 RPA1 [activation] CASP7 AR [activation] AGAP3 YWHAB [activation] KIF23 YWHAZ [activation] FASLG MYO15A [activation] HMGA2 PCBP2 [activation] 页 38 共 454


2016/4/8 19:14

SFN SAMD4A [activation] BHLHE40 DAB1 [activation] XRCC4 PRKDC [activation] EP300 MAX [activation] MAPKAPK5 JUN [activation] MYC PPA2 [activation] POGLUT1 FBXO6 [inhibition] PPA1 HSPB1 [activation] SH2D3A SFN [activation] PTGIR PRKCA [activation] OPRD1 GNAI2 [activation] CHEK2 CYP17A1 [activation] HIST1H3A RAC1 [activation] NME5 DYDC2 [activation] NFYB AGTRAP [activation] TRAF7 CYLD [inhibition] E2F1 CWC27 [activation] RPA1 TAGLN2 [activation] DAB1 PLCG1 [activation] UGT1A3 UGT1A7 [activation] PDGFB LRP1 [activation] RSL24D1 CDC23 [activation] CDC25A FZR1 [activation] PIM1 EPHA3 [activation] VASP VCAM1 [activation] HMGB1 HSPA8 [inhibition] TP53 TDG [activation] IL27RA GOSR1 [activation] JAM3 TJP1 [activation] TTBK2 CRK [activation] SET ETS1 [activation] SCTR SCT [activation] APC PPP1R13B [inhibition] PLEKHG5 RND3 [activation] CDK18 TRIM54 [activation] MAPK14 ARHGAP9 [activation] RECQL5 DDX42 [activation] STX1A CACNA1D [activation] EGFR CEBPB [activation] RAD21 CCDC7 [activation] MIS12 FGA [activation] LAMTOR5 SHB [activation] REV3L CHEK2 [activation] PARD3 PLCB1 [activation] SMAD3 CHUK [activation] PHIP STMN4 [activation] YWHAQ FOXO1 [activation] AMBRA1 TRAF6 [activation] TNF ST13 [activation] MAGED1 BHLHE40 [activation] HSPA1L H2AFX [activation] PTPRJ GRB2 [activation] DKK3 CDH1 [inhibition] PRKCI USP20 [activation] EGFR HIST1H4A [activation] TSC1 ETS1 [activation] STK11 CTSB [activation] CALM1 PPEF1 [activation] RAB7A RPA1 [activation] LRRK2 ACLY [activation] ITGA4 PYCR1 [activation] ATXN10 ILK [activation] PPP2R5A BCL2 [activation] CAMK4 HSP90AB1 [activation] DOCK8 SMAD2 [activation] HSPD1 NR3C1 [activation] MDM2 OXCT1 [activation] DOCK3 SRC [activation] MAP4K1 MAP3K11 [activation] PCNA TRAF6 [activation] GNAS GNGT1 [activation] TGFBI COL4A1 [activation] OBSL1 CCAR2 [inhibition] SMYD2 AHI1 [activation] MAX ZBTB17 [inhibition] CASP4 SMC3 [activation] 页 39 共 454


2016/4/8 19:14

MDM2 MRPS23 [activation;inhibition] PRKCB YWHAG [activation] ITGA4 YWHAZ [activation] AGK FBXO6 [inhibition] CDC20 ANAPC15 [inhibition] STK4 STRIP1 [activation] WAS RHOQ [activation] WT1 PRKACA [activation] PDCL2 YWHAB [activation] RPS6KA4 CDC5L [activation] EPAS1 SMARCB1 [activation] SRPK1 CLIC5 [activation] PRC1 KIF23 [activation] RHBDL2 EFNB3 [activation] MDM2 TACO1 [activation] MYOC TIMP1 [activation] PIK3CA THRSP [activation] PRKCB PTPN11 [activation] ADAP2 IKBKG [activation] TNIK MAP3K7 [activation] CALM1 RELA [activation] FRS2 PRKCZ [activation] PXN CBL [activation] QPCTL LRRK2 [activation] CNTN1 NOTCH1 [activation] NEDD8 ERCC4 [activation] C5AR1 WAS [activation] TGFBR1 PAK1 [activation] PTGDR HSP90AA1 [activation] VTN PASK [inhibition] PSEN1 EFNB2 [activation] TAF1 MDM2 [activation] RXRA NFKB1 [inhibition] ESR2 EIF2A [activation] HSPA5 STMN1 [activation] GRB2 SPTBN1 [activation] ENOX2 MAGEA11 [activation] UNG RPA2 [activation] LATS1 PTPN13 [inhibition] ARRB2 CAMK2D [activation] PIK3CA RASD2 [activation] RAB32 NXF1 [activation] JAK1 PDGFRB [activation] GNGT1 PLEKHB1 [activation] PDE4DIP PRNP [activation] HSP90AB1 ANKMY2 [activation] SRC AKAP2 [activation] FAS TMX1 [activation] APOA4 NR1D1 [inhibition] MAP4K4 OBSL1 [activation] RPTOR LAMTOR1 [activation] CHEK2 NR4A1 [activation] DIAPH3 SIRT1 [activation] DIP2B MYC [activation] HSPA8 CTNNB1 [inhibition] WIF1 ICOS [activation] ITGB4 SMAD3 [activation] COL1A1 COCH [activation] RELA CHEK1 [activation] RPA1 EIF2S1 [activation] SMAD4 DDX39B [activation] MYC CSF1 [activation] FYN EPB41L3 [activation] MYO9A MYC [activation] CRK MAPK4 [activation] IRF3 TICAM2 [activation] FYN PRICKLE3 [activation] H2AFX PBK [activation] MDM2 EIF2AK1 [activation] HDAC3 NFKBIA [activation] PIK3R1 TNFRSF1A [activation] HSP90AA1 CDKN1A [activation] DARS VCAM1 [activation] ACTB SMAD9 [activation] IRF4 STAT6 [activation] PIN1 DDX24 [activation] 页 40 共 454


2016/4/8 19:14

CASP7 PTMA [activation] PTPN2 INSR [activation] ACOT7 CAMK2B [inhibition] CDH1 TP53BP2 [activation] LRRK2 DIAPH1 [activation] SMAD3 PPP2R1A [inhibition] EIF4B YWHAZ [activation] RBPJ SUFU [inhibition] IRS2 PIK3CD [activation] ANXA2 CTSB [activation] PPP2R1A NKD1 [inhibition] ITGA4 SNRPA1 [activation] ANXA2 PPP2R1A [activation] CDK11B VDR [activation] NUMB ITGB2 [activation] NOTCH1 GATAD2B [activation] ERBB2 BAIAP3 [activation] ARRB2 MDM2 [activation] RAF1 CNKSR1 [activation] IDH3B MAPK6 [activation] ERBB2 PAK1 [activation] RAC1 SH3BP1 [activation] HCK KIT [activation] GABARAPL2 MTPN [activation] KIFC3 CDK18 [activation] SERTAD1 RHOB [activation] STAT5A CENPJ [activation] OPRK1 GABARAP [activation] COL3A1 PDGFB [activation] GABARAP DDX24 [activation] SNCA SPTBN1 [activation] BARD1 DYRK1A [activation] EPHB2 FOS [activation] CRK DOK4 [activation] CDK5 DAB1 [activation] TGFB2 TGFBR1 [activation] PRKCE PRKD1 [activation] SPRR4 APP [activation] KLF10 CDK6 [inhibition] MLH1 WDR61 [activation] ZNF579 ILK [activation] HIST1H2BB ICAM1 [activation] HNRNPD CAPN1 [activation] NFKBIA HSPA8 [inhibition] APP SDC1 [activation] TP53 EP300 [activation] CD19 IFITM1 [activation] USP7 DNAJA3 [inhibition] PTK2 PTK2B [activation] BRCA1 AKT1 [activation] CEP170P1 CLHC1 [activation] PTK2 INSR [activation] RAC1 PAK1 [activation] STAT3 PDGFRA [activation] PLCG1 AGAP2 [activation] EIF5 NRGN [activation] VCAM1 HIST1H1E [activation] SMAD4 SHC1 [activation] SIRT1 MECOM [activation] SP1 RXRA [inhibition] CHEK2 DAPK3 [activation] MAPT RPS6KA1 [activation] PLG SMAD3 [inhibition] SH2B2 NTRK1 [activation] PRNP APP [activation] EGFR EIF2B5 [activation] GP6 HCK [activation] COL4A1 PDGFB [activation] BCL3 EP300 [activation] MTOR MAPK8 [activation] RAF1 RFXANK [activation] EPB41L3 NR3C1 [activation] SETX MYC [activation] ATF3 MDM2 [activation] CXCL11 LRRK2 [activation] ETS1 DAXX [activation] 页 41 共 454


2016/4/8 19:14

MAST2 STK36 [activation] MAPK13 IQGAP1 [activation] PHACTR2 PLCG1 [activation] HLA-B BCAP31 [activation] PTK2 PPP1CA [activation] UBAP2 G3BP2 [activation] SGTB SERPINE1 [inhibition] SRPK3 GAR1 [activation] CSNK1G1 RUNDC3B [activation] HABP4 PRKCB [activation] BARD1 MT2A [activation] KAT2B TACC3 [activation] MAP2K1 BTRC [activation] WNK1 GLIS2 [activation] FYN FAM110A [activation] JAK3 LEPR [activation] MS4A1 CD40 [activation] C11orf68 KCNE3 [activation] MAP3K14 ACTG1 [activation] SCG3 DNM1L [activation] STX1A SNAP25 [activation] GLI1 ITCH [inhibition] ACTA1 PTPN1 [activation] CD81 KIT [activation] PRTN3 ITGB2 [activation] CREM TBP [inhibition] NCAPD2 SIRT6 [activation] HSP90AA1 IRF2 [activation] RAD21 TMSB4X [activation] EGFR CMTM8 [activation] NCOA3 SMAD2 [activation] CBL IRF1 [activation] ERP44 ERO1L [activation] ICMT RHOA [activation] GNAQ PIK3R1 [activation] EIF1 MAPK6 [activation] IQGAP3 LRRK2 [activation] CBL VCAM1 [activation] NCKAP5 VAV2 [activation] RIPK1 HSP90AB1 [activation] TGFB1 TGFB2 [activation] AK2 TRAF6 [activation] CALM1 CAMKK1 [activation] HSPB1 RIF1 [inhibition] YWHAB RIOK1 [activation] ZBTB18 MYC [activation] IRF1 HIST1H3A [activation] EIF4A3 PRMT5 [activation] TNFRSF14 DRAP1 [activation] GRIA2 GRIK2 [activation] DNAJB6 GH1 [inhibition] RPL35A RAD21 [activation] FASTKD3 AGTRAP [activation] DOK5 NTRK3 [activation] CD4 TFRC [activation] MAPK1 LRPAP1 [inhibition] UBC BCL2L1 [activation] PIK3C2B PDGFRB [activation] NOTCH1 XIAP [activation] PYHIN1 ZNF428 [activation] F10 F5 [activation] CLTC WNK1 [activation] ATG5 PAK1 [activation] FOS RPS6KA1 [activation] SEC31B MYC [activation] CASP3 STAT1 [activation] DMPK RAC1 [activation] SRSF10 OBSL1 [activation] HSPA9 RIPK1 [activation] SKIL SASH1 [activation] GATA1 MAPK6 [activation] DYRK1A LIN52 [activation] ME2 WNK1 [activation] YWHAQ APC [inhibition] STX1A RIMS1 [activation] APPL1 FSHR [activation] 页 42 共 454


2016/4/8 19:14

PHLDA3 IDH3B [activation] TRIB3 PRMT5 [activation] MAGEA9 EGLN1 [activation] ABL1 RAD52 [activation] NOD1 CDC37 [activation] SRPK1 ESRRG [activation] RAB4A ACTB [activation] LURAP1 DOCK10 [activation] TTI1 ATM [activation] NFKB2 ACTG1 [activation] MYC DNM2 [activation] APP NDEL1 [activation] TYK2 FYN [activation] LIN54 EIF4H [activation] NOVA1 SRPK1 [activation] KAT2B SMAD9 [activation] CD247 RLTPR [activation] CTBP1 MYC [activation] MMP1 TFPI [activation] CR2 IFITM1 [activation] BRD7 LAMA4 [activation] NUP62 SNAPC5 [activation] RLN3 RXFP1 [activation] FYN TRPV4 [activation] CARD8 CASP9 [activation;inhibition] GADD45G CDKN1A [activation] EPS15 TFRC [activation] HOPX SRF [activation] PDX1 ATF3 [activation] GRB2 ITGA4 [activation] PLN TMEM79 [inhibition] EFCAB4B CDC23 [activation] FTSJ1 HPRT1 [activation] EGFR SNCA [activation] EGR1 LEF1 [activation] YWHAB RADIL [activation] ACTL6A TP53 [activation] APP SYK [activation] MAPKAPK2 NXF1 [activation] POLK POLD1 [activation] GZMB GRIA3 [activation] ESR1 ARHGDIA [activation] CDH1 EZR [activation] ATG4B STK3 [activation] F2RL2 JAM2 [activation] TERT MTOR [activation] PRKG1 PPP1R12A [inhibition] FANCA FANCE [activation] ZNF24 RICTOR [activation] CEBPA CDK2 [activation;inhibition] C11orf49 CDC16 [activation] RPL24 TP53 [activation] SRC ESRRA [activation] STC2 EIF2B3 [activation] PTEN BEX1 [activation] ANAPC7 SMARCAD1 [activation] EIF2AK2 FARSA [activation] CAB39 BCKDK [activation] ESR1 DDX27 [activation] ESR2 SMARCA5 [activation] EXT1 TRAP1 [activation] BARX1 MAPK6 [activation] XIAP CASP10 [activation] MYOD1 SETD7 [activation] NUP107 NUP214 [activation] CLOCK RARA [activation] SRPK2 NSMCE4A [activation] STAT5A STAT3 [activation] PYCARD TSHZ2 [inhibition] CDKN1C FBXL12 [inhibition] STAT3 GADD45GIP1 [activation] CTDSP1 POLR2A [activation] MAP3K1 MAPK1 [activation] ABCA1 DLG5 [activation] TP53 ZMIZ1 [activation] SRPK2 NXT2 [activation] 页 43 共 454


TRAF6 TRAF1 CIITA SIRT1 PAXIP1 PPARG H2AFZ CTCF MAVS ITCH NOTCH2NL MYLK SRC DNAJB2 HDAC11 ULK1 TBC1D14 CTNNA2 YAP1 GNA12 CDH15 SRPK1 ZNF514 EIF4A3 DDX17 SH3RF3 CDC42 STK40 LRRK2 COPS6 STX5 NUDC KLHDC8A DDX5 AURKB ATP2B1 PRKCA NFKB1 STAT5A NPHP3 CEP164 KPNA2 SGK1 AKT1 PEBP4 TRAF6 PELI2 CD28 VAV1 FCER1G PLCG2 METTL21C MRPS27 AURKB TP53 COPS6 E2F1 MOV10 ADIPOQ PDGFB GNL3 CDKN2A DDX21 TRAF6 IRAK2 YTHDF1 BCL6 LPAR4 GNB2L1 PRKCA SUV39H1 NR1H2 MAPK9 CDC25B FADD RALGDS UFM1 UFC1 TNFRSF10B YWHAZ NOS2 RAC1 IQGAP2 ATF2 FOSL1 TTC5 CAMK2B GBF1 KBTBD7 RASA1 PDGFRB FYN GPR45 OXSR1 BMPR1B GCA LCP1 HIF1AN ILK WDR37 SFN PDLIM7 GEM RPA2 APC FOSL1 HDAC1 ACTG1 EPS8L3 RPS14 TP53 STRA13 TRIM54 XIAP RIPK4 ACTG1 FBXO6 FANCA MX1 PLCG1 IBTK GRM5 PRKCG MAGI2 ACVR2A MLH1 BLM XRCC3 PALB2 ROR1 WNT5A SMYD2 PTGES3 ARRB2 GCG ITGB3 ITGA5 IL7R KIT SMURF1 STK35 ACTG1 LGR4 PTTG1 BUB1B WAS APBB1 YAP1 ABL1

2016/4/8 19:14

[activation] [activation] [activation] [activation] [activation] GIP [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] HSPA8 [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] CBL [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] 页 44 共 454


2016/4/8 19:14

PPP1CA MYC [activation] FGF3 FGFR4 [activation] RHOB FBN1 [activation] AKR1B10 ACACA [activation;inhibition] RANBP9 LTB4R2 [activation] SIKE1 PPP2CA [activation] TIMELESS RPA3 [activation] SKI TP53 [activation] HSP90AB1 SHC1 [activation] SMARCA4 HSF1 [activation] ENO1 SERPING1 [inhibition] HDAC3 NFE2L2 [activation] TSEN54 NXF1 [activation] NR3C1 YWHAH [activation] PDIA4 TRAF6 [activation] SLC9A3R1 GNA11 [activation] ADAMTSL5 NOTCH2NL [activation] RNPC3 PRNP [activation] SRC EFNB2 [activation] MAPK7 ETS1 [activation] RASL12 SMAD1 [activation] CHUK NOTCH3 [activation] PKN3 PLD1 [activation] ANAPC7 FBXO5 [activation] GSDMB PEBP1 [inhibition] ANAPC11 TRIM65 [activation] ABL1 XPO1 [activation] TFDP1 LIN37 [inhibition] TAB1 DNAJC7 [inhibition] HNRNPA1 ESR1 [activation] CCNG2 SKP2 [inhibition] CDK6 CDC37 [inhibition] GNAQ CYTH3 [activation] DDX5 LRRK2 [activation] YWHAQ PRKCQ [activation] KIR2DS2 HLA-C [activation] SMAD4 DVL1 [activation] NCOR2 PPARA [activation] ADRB2 SLC9A3R1 [activation] MYO5A MYC [activation] YWHAZ WEE1 [activation] CDH3 IGF1R [activation] EGFR PRKAR1B [activation] SMURF1 XPO1 [activation] GNAZ EYA2 [activation] PBX1 CREBBP [activation] UBE2I ESR1 [activation] MAPK9 PIK3R1 [activation] HAPLN1 MMP10 [activation] HSPB1 PHYHIPL [activation] DMWD PHLPP1 [inhibition] RPS17 FOS [activation] A1BG ANXA7 [activation] FCHSD2 WAS [activation] MAPK3 PLCB1 [activation] VCAM1 IGF2BP2 [activation] WDR5 PRNP [activation] TNS3 BCAR1 [activation] CAPZB FAM21C [activation] CDK1 SOX2 [activation] AGFG1 VAMP7 [activation] IKBKB SRC [activation] PTK2 SOCS3 [activation;inhibition] HSP90AB1 KLHL38 [activation] HSPA4 BCL2L11 [activation] HNF4A TRIM24 [activation] ENO2 ASB9 [activation] BCL2 LRRK2 [activation] URM1 NUP160 [activation] SENP3 CDK4 [inhibition] TP63 EP300 [activation] SNAI2 APP [inhibition] MMP14 FGFR2 [activation] MAP2K5 HSP90AA1 [activation] FADS2 EGFR [activation] CRKL CBL [activation] 页 45 共 454


2016/4/8 19:14

C4A APC [inhibition] SRPK1 C9orf72 [activation] RAD21 PIGR [activation] IFRG15 LRRK2 [activation] PPP2CA MRPS26 [inhibition] RAC1 DVL1 [activation] MAPT RPS6KA5 [activation] BCL2L1 BIK [activation] PRNP P4HB [activation] STK16 ROCK2 [activation] ACTA1 MYLK [activation] MARS NFKB2 [activation] ZFYVE27 RAB11A [activation] CCNA2 AKT3 [activation] TRAF6 ABL1 [activation] AURKB TCEAL4 [activation] WASF1 FYN [activation] GADD45G PPARG [activation] GIT1 TGFB1I1 [activation] GRB2 ABLIM1 [activation] WRAP73 CDK2 [activation] C5 C8B [activation] ESR1 PRDX2 [activation] EGFR PTPN18 [activation] NRAS AKT1 [activation] TRAF1 TRAF2 [activation] E2F3 CCDC9 [activation;inhibition] HSP90AA1 CDH1 [activation] KPNA2 VCAM1 [activation] APITD1 TOP3A [activation] TTBK1 TTBK2 [activation] ATM SOCS1 [inhibition] NUP62 TXLNA [activation] SMAD2 MCF2L [activation] PRKCD IL6ST [activation] ACTB CSNK1A1 [activation] PIK3R6 RAPGEF3 [activation] EGFR MCM4 [activation] GTF2A1 GCN1L1 [activation] CDK1 GADD45G [activation] DVL1 SMAD7 [activation] PSEN2 LIPF [activation] GAB2 CRKL [activation] HES1 FANCF [activation] TFRC TP53 [activation] MAD2L2 REV3L [activation] YWHAZ RAD52 [activation] PTPN2 STAT3 [activation] HSPG2 LAMA1 [activation] GNB2L1 EPOR [activation] TNFSF13 XPO1 [activation] NCOA3 DDX5 [activation] INS HLA-DQA2 [activation] DMPK FXYD1 [activation] BARD1 PTN [activation] TRAF1 CASP8 [activation] CDC42 CNTNAP1 [activation] LAMA1 SAA1 [activation] C4BPA BMPR2 [activation] TBK1 TRAF2 [activation] CREBBP NKX2-1 [activation] EZR EGFR [activation] CDC25B BRSK2 [activation] PAK3 PLK1 [activation] SNURF TP53 [activation] IKZF3 RHOA [activation] LCK CSF3R [activation] ARF1 MDM4 [inhibition] DDX39B SREK1 [activation] RB1 PML [inhibition] KLKB1 MST1 [activation] NPHP3 NPHP1 [inhibition] NCK1 LCP2 [activation] MORN4 HMMR [activation] AMOTL2 RAD51D [activation] RGS2 DDR1 [activation] 页 46 共 454


2016/4/8 19:14

RBX1 MAP4K1 [inhibition] SMAD2 MTMR4 [activation] HDAC2 CCND1 [inhibition] FRS2 GRB2 [activation] ARHGDIB EZR [activation] TRAF6 LGMN [activation] AXIN2 AMMECR1 [inhibition] FRAT1 GRN [activation] BEND5 GRAP2 [activation] LCE4A OTX1 [activation] BCL2L11 MCL1 [activation] GNAI2 PLSCR1 [activation] PLCG1 DNM1 [activation] AIM2 NBN [activation] SPRR2A CRK [activation] ELK1 CEBPB [activation] ICAM5 ITGAL [activation] GNB2 TRAF6 [activation] HIST1H2BL MYC [activation] SRC PDIA2 [activation] NFKBIA TIMM50 [activation] ILK IRS4 [activation] HSP90AA1 EIF2AK2 [activation] SERPIND1 CTSG [inhibition] PTPN6 PRKCD [activation;inhibition] TIPRL PPP6C [inhibition] RAD21 SMARCA5 [activation] LARS RPTOR [activation] PTK2 LCK [activation] C16orf70 APP [activation] SAV1 GLMN [activation] ZFPM2 EP300 [activation] RAC1 NCF1 [activation] SSTR1 CORT [activation] PRPF6 NOTCH1 [activation] RELB ACTG1 [activation] INSR IGF1R [activation] PTGES3 ERBB3 [activation] SERPINB8 F10 [inhibition] COL4A1 MMP9 [activation] SCARB1 CAND1 [activation] FGF2 HSPG2 [activation] UBE2C ENO2 [activation] SNRNP70 IL32 [activation] GRB2 IGF2BP1 [activation] CDKL5 PRKG2 [activation] CCNG1 PPP2R1A [activation] CNKSR1 STK3 [activation] BCL7C SMARCA4 [activation] ACTB CDC5L [activation] NFE2L2 PRKCH [activation] CLIP1 RAC1 [activation] ERC2 MYB [activation] CCDC93 EXOC1 [activation] NFE2L2 PPARG [activation] HMGN2 GRB2 [activation] CPE GCG [activation] UBE2H RNF166 [activation] SRSF10 CSNK2A1 [activation] EIF4EBP3 RPA2 [activation] PALB2 CASZ1 [activation] CCNG1 PPP2CA [activation] ARRB2 KPNB1 [activation] PPP6C MOB1A [activation] FYN YTHDC1 [activation] MAPKAP1 SFN [activation] NR3C1 MDM2 [activation] OPRM1 WLS [activation] RECQL5 TOP3B [activation] PACSIN1 APBB1IP [activation] MYO1B MAP1LC3A [activation] TJP1 MLLT4 [activation] DOCK1 FYN [activation] GNG3 GNAI3 [activation;inhibition] SGK1 HYOU1 [activation] ADAM17 FHL2 [activation] 页 47 共 454


2016/4/8 19:14

IER3 TNFSF10 [activation] SSH1 YWHAB [activation] MOB3B MAPK14 [activation] SUCLG1 MYC [activation] CAPN1 CTSC [activation] BMPR2 LIMK1 [activation] CORT MRGPRX2 [activation] PRKDC GZMB [activation] PLK1 ITSN1 [activation] INSR AHSG [inhibition] PDCD6 GRB2 [activation] MIF HLA-B [activation] POLD4 POLD3 [activation] CASP3 USO1 [activation] CNTN2 CNTNAP2 [activation] HIF1A BCR [activation] PITPNM3 CCL18 [activation] MAP2K2 IQGAP1 [activation] KRT15 GRB2 [activation] ITGB1 ICAM4 [activation] CADPS DRD2 [activation] RASSF5 STK4 [activation] ARF6 YARS [activation] NR3C1 EGFR [activation] S1PR2 ITGB4 [activation] DIXDC1 DVL2 [activation] RAC2 TNFAIP8L2 [activation] IGSF8 HIST2H3A [activation] MYB STAT5A [activation] APC JUP [inhibition] AR CDC25A [activation] BUB1 EIF4EBP1 [activation] BMP2 ACTR2 [activation] SLAIN2 GRB2 [activation] NFKBIE PRKDC [activation] SNCA COL25A1 [activation] EED ANXA5 [activation] RIMS1 SMAD2 [activation] DAAM1 ARHGEF11 [activation] APBB1 EGFR [activation] SMAD4 DNAJB2 [inhibition] ANAPC7 CCDC8 [activation] SMARCB1 BAZ1B [activation] CCDC102B MAB21L2 [activation] PPP2R1A PRR14 [inhibition] MZT2A CDK5RAP2 [activation] PRPF3 AURKB [activation] PPP1R2P3 PPP1CA [activation;inhibition] TGFBR1 CHUK [activation] TXNDC5 H2AFX [activation] TJP2 SRPK1 [activation] SRC P2RY2 [activation] SKIL CPNE1 [activation] C1QA RAC1 [activation] OBSL1 MGA [inhibition] INSR JAK2 [activation] IGF1R LYPD3 [activation] GRB2 LIME1 [activation] PDPK1 IRS1 [activation] BTRC CDC25A [activation] GRB2 PKM [activation] RALA ARF1 [activation] NXF1 PRUNE [activation] FOS TSPYL4 [activation] TRMT1L EGFR [activation] NCK2 LCP2 [activation] CASS4 CRK [activation] AGFG1 VCAM1 [activation] TTC3 ETS1 [activation] VAV1 ERBB3 [activation] ABL1 ERBB3 [activation] GNA14 DNAL4 [activation] BTG2 SMAD9 [activation] SMAD2 RXRA [inhibition] OBSL1 UTP6 [activation;inhibition] BRCA1 CLSPN [activation] 页 48 共 454


2016/4/8 19:14

ERBB3 CDK5 [activation] PTPRG INSR [activation] MAPKAPK2 YWHAZ [activation] GCSH NMI [activation] MAPKAPK3 LNX1 [activation] CACNA1E GNB2 [inhibition] NR5A1 DDX39B [activation] TAF1B EP300 [activation] SMARCA1 GRK5 [activation] SRPK3 SF3B4 [activation] LRRK2 HNRNPH3 [activation] PPARG EP300 [activation] SH2D1A ERBB3 [activation] PTN ARL15 [activation] MAP2K6 LRRK2 [activation] TRIM29 SHOX2 [activation] TP53 BCL2L1 [activation] WFIKKN2 BMP8B [activation] SOX2 IQGAP3 [inhibition] HSPA6 E2F3 [inhibition] MOS TRAF1 [activation] EPHA4 FZR1 [activation] CASP3 BID [activation] PTPRC PXN [activation] PCYT1A CASP6 [activation] PDPK1 LUC7L2 [activation] BOLA1 RGS20 [activation;inhibition] CXCR2 GNA15 [activation] SHKBP1 CCNG1 [activation] PPP2R1B ANXA5 [activation] HTRA2 MAPK11 [activation] PSMB3 INSIG2 [activation] NR3C1 PTMS [activation] ELK1 CDK6 [activation] EGFR ANKRD13D [activation] INSC PARD3 [activation] CCDC33 MAPK9 [activation] ACTN1 ADORA2A [activation] HSPB1 RALA [activation] FBXO15 SKP1 [inhibition] HLA-B SRC [activation] A2M TYRO3 [inhibition] STAT4 CREBBP [activation] TOLLIP ANKRD13A [activation] PRPF6 RAF1 [activation] NAT1 LRRK2 [activation] NUP62 PIN1 [activation] TRAF6 TMBIM6 [activation] CUL1 DBNL [inhibition] MLNR MLN [activation] PDE6G MAPK3 [activation;inhibition] WHSC1L1 AKT1 [activation] CTTN PAK1 [activation] APBB1 H2AFX [activation] TNFRSF1A CLIP3 [activation] E2F1 NDNL2 [activation] FANCG CDK1 [activation] PTK2B CRK [activation] CBLB GLRX3 [inhibition] GADD45A PTN [activation] CDK5R1 HSP90AA1 [activation] PDGFB PDGFA [activation] COL1A1 PAK1 [activation] MYC SLC25A11 [activation] HTR2A MRPL28 [activation] BHMT2 APP [activation] CRTC2 HECW2 [activation] SPP1 MMP3 [activation] ITGA4 VASP [activation] PARD3 STK11 [activation] RFC2 PAXIP1 [activation] GIMAP5 BCL2 [activation] CDH1 AJAP1 [activation] LRRK2 RIF1 [activation] YWHAB CHEK1 [activation] STRBP LRRK2 [activation] 页 49 共 454


2016/4/8 19:14

NCAM1 FYN [activation] ESRRA MACF1 [activation] STAT3 STAT6 [activation] SHC1 HSP90AA1 [activation] ARAF PDGFRB [activation] RPS6 ITGA4 [activation] FASN CDC5L [activation] DOK4 TEK [activation] SMAD1 ICK [activation] SDC4 TGFB3 [activation] CDKN1B YWHAH [activation;inhibition] BIRC2 UBE2W [activation] EP300 TP73 [activation] RIPK1 NOD2 [activation] SAE1 BCL6 [activation] ANAPC2 FZR1 [activation] NKX2-1 PAX8 [activation] CDC37 BRAF [activation] ST7 ZFYVE9 [activation] U2AF2 SRPK2 [activation] HSPB1 FAM71D [activation] SP3 TP53 [activation] VCAM1 ZYX [activation] NLRC4 CASP8 [activation] RNH1 ANG [activation] LUC7L2 APP [activation] CISH SMAD2 [inhibition] ODF1 CDK5 [activation] LRRK2 NUP153 [activation] PIK3R1 CDC27 [activation] MBP PRKCZ [activation] SBDS MAGEA6 [activation] ARMC2 IGHG1 [activation] KIAA1377 PIK3R3 [activation] RNF2 EIF2S2 [activation] TNFRSF1A SRC [activation] ENAH ABI2 [activation] LATS1 MOB3B [inhibition] CTSV APC [inhibition] HRAS IL24 [activation] LIMS1 CTGF [activation] SLAMF1 FGR [activation] NR1H3 LZTR1 [activation] PHF23 STK11 [activation] IGLL1 MME [activation] YWHAB SRC [activation] KIR2DL1 PIK3R1 [activation] RPA1 ERCC6 [activation] XPO7 ILK [activation] NOS1 CAV3 [activation] ESR1 FOXO3 [activation] RARS HLA-B [activation] LRRK2 WDR5 [activation] EGFR TRAPPC3 [activation] HNRNPM RELA [activation] RHOG VAV1 [activation] CDK11B YWHAE [activation] STK11 RPAP3 [activation] PIK3C3 PRMT5 [activation] TSPAN7 RBL1 [inhibition] NXF1 PLCG1 [activation] WASL PACSIN1 [activation] TP53TG3 LRRK2 [activation] AANAT F2 [activation;inhibition] IGF2BP1 ARHGDIA [activation] SMAD1 PAX6 [activation] PAK1 PXN [activation] CDC27 PAXIP1 [activation] LYN RPS6KB1 [activation] EIF4G1 TNRC6C [activation] EP300 MAML1 [activation] MOS CCDC33 [activation] NSD1 HIST1H1C [activation] SMARCA4 SMAD2 [activation] BCL6 ZNF443 [activation] CIAO1 FMNL2 [activation] 页 50 共 454


2016/4/8 19:14

CSNK1A1 PSEN2 [activation] NXF1 ANAPC13 [activation] ELAVL1 CHEK2 [activation] ENO2 NAT9 [activation] OLA1 SGK1 [activation] LCE3C NOTCH2NL [activation] CDK6 ISL1 [activation] MYO1D CHUK [activation] RAPGEF6 NXF1 [activation] NXF1 SH3KBP1 [activation] CHUK STAP2 [activation] ERBB3 MRPS34 [activation] INO80 H2AFX [activation] AR BLNK [activation] TRAF6 ULK1 [inhibition] RELA COMMD2 [activation] RHPN2 TGFBR1 [inhibition] JUP CTNNB1 [activation] PHF8 RBPJ [inhibition] SMC1A ATM [activation] CLTCL1 PICALM [activation] MTMR12 MTM1 [activation] MCM3 STAT1 [activation] YAP1 KLF5 [activation] RPA3 SRBD1 [activation] HELB POLA2 [activation] C5 CPN1 [activation] NOV CDKN1A [activation] F2R ELANE [activation] SYT9 SNAP25 [activation] CDC42BPB PYGM [activation] HSPB1 TARBP2 [activation] HLA-B TXNDC17 [activation] NPDC1 CCND1 [activation] ATP6V1A MYO1B [activation] PTGES3 EIF2AK2 [activation] CCND1 NRF1 [activation] DNTTIP1 RPA3 [activation] PPP2R1B CAV1 [activation] ATXN7L2 LAMB1 [activation] NUDT18 RAD54B [activation] TNIK IKBKB [activation] YARS EGFR [activation] CDC25A APP [activation] CDK5 GAK [activation] EGFR ABL2 [activation] TP53 SMARCD2 [activation] IL3RA JAK2 [activation] CDC5L DIAPH1 [activation] FBXL13 HSP90AB1 [activation] ARHGDIA MAPK6 [activation] DLGAP4 NXF1 [activation] ARNT2 NPAS2 [activation] SVIL GRB2 [activation] MDM2 ARHGEF6 [activation] TRAF6 CARHSP1 [activation] PLCG1 RHOU [activation] EIF4EBP1 MAPKAP1 [inhibition] ADRB2 IDH2 [activation] YWHAH TSC1 [activation;inhibition] RB1 HIF1A [activation] IRS4 MTNR1A [activation] XPOT NUP214 [activation] UBE2N RNF165 [activation] SMURF1 BMPR1B [inhibition] NRIP1 TULP3 [activation] CD4 EPS15 [activation] SLX1A ERCC4 [activation] CAMK2B PLCB3 [activation] HDAC1 SP1 [activation] CDK10 HSP90AB1 [activation] FBXO6 LTBP3 [inhibition] SH3KBP1 ANAPC5 [activation] ZIC3 SRF [activation] RHOH RHOA [activation] PPP2CB CDK18 [inhibition] 页 51 共 454


2016/4/8 19:14

RNF219 CNOT10 [activation] RELA CDKN2A [activation] EGFR ERBB2 [activation] DVL1 CSNK1D [activation] CACNB1 GEM [activation] PLAC9 CCDC14 [activation] DDAH2 ANXA7 [activation] HIST1H2BC CD81 [activation] FYN SEPN1 [activation] DDX24 NRXN2 [activation] LRRK2 FARSA [activation] OGT SETD1A [activation] SPRY4 GRB2 [activation] STAT3 FER [activation] EZR TSC1 [inhibition] PGAM5 STRN3 [activation] MRFAP1L1 TXN2 [activation;inhibition] MED1 GATA4 [activation] NXF1 CCNG1 [activation] SH3GL3 SHC3 [activation] NCAPD3 SLX4 [activation] PPP1CC PPP1R3D [inhibition] NCOA1 ESRRG [activation] GSK3B CTNND1 [activation] NDUFA4L2 KCNA4 [activation] AR RAF1 [activation] TXK ERBB3 [activation] MAPK14 GORASP2 [activation] IPO5 VCAM1 [activation] IRS2 NISCH [activation] PPP2R1A FTSJ1 [activation] FUS SRSF10 [activation] FOS HNF1A [activation] INPP5K HSPB1 [activation] HIST3H3 VCAM1 [activation] CFL1 RAD21 [activation] FKBPL ESR1 [activation] F10 APOH [activation] SUMO1 HLA-C [activation] GAB1 PRKCI [activation] CASP1 NFE2L2 [activation] TLE2 HMGB1 [inhibition] MSL1 CRKL [activation] SYMPK KMT2A [activation] CDC25A XPO1 [activation] TANK MAP4K5 [activation] SMARCC1 MYC [activation] NOXA1 PRKACA [activation] SKIL SMAD1 [activation] SDCBP DAK [inhibition] DNM2 ABL1 [activation] TGFBR1 PREX2 [activation] C8orf33 NXF1 [activation] EEF1A2 CHUK [activation] MAPT CALM1 [activation] ARHGEF19 DVL1 [activation] EGFR ITCH [activation] MAPK10 CDKN2A [activation] CDK4 TGFBR1 [inhibition] CD300LD TFF1 [activation] MUTYH RPA1 [activation] HSPB1 ITGA4 [activation] ARF6 SMC2 [activation] ARF1 ATF2 [activation] CAMLG KCNA2 [activation] CASP3 MAPK8IP3 [activation] CDC5L ANXA7 [activation] TBK1 RELA [activation] MAPKAPK3 CDKN2A [activation] FAM203A POLA2 [activation] SPTAN1 ERCC4 [activation] BAG2 DNAJC6 [inhibition] PRKACA FXYD1 [activation] ENKD1 DVL3 [activation] PPP2CA BMPR1B [inhibition] PIK3R1 FLNB [activation] 页 52 共 454


2016/4/8 19:14

PAK7 RPA3 [activation] NR1H3 FOXO3 [inhibition] ICT1 MRPL12 [activation] YES1 TRAF2 [activation] SAV1 RASSF4 [activation] SNW1 MLH1 [activation] RPA3 RAB13 [activation] NOTCH2NL HIST1H2AG [activation] ZAK IGHM [activation] BCL6 FBXO11 [activation] SMAD7 TOLLIP [activation] CACNA1A CACNB4 [activation] SPP1 EEF1A1 [activation] RAP1A RAP1GDS1 [activation] RAB5A KCNN3 [activation] PICK1 GRIA2 [activation] TUBG1 NBN [activation] UBE2K HLA-B [activation] SRPK2 DHX8 [activation] DUSP15 FYN [activation] STK4 IPO7 [activation] ROBO1 ROBO4 [activation] BLNK ERBB2 [activation] MAP3K7 HIST1H4A [activation;inhibition] PLEKHO1 SMURF1 [inhibition] PIK3R1 HGS [activation] MYC CALD1 [activation] RELA POTEJ [activation] CREG1 CAPN1 [activation] KIAA0232 WNK1 [activation] TXLNA STX3 [activation] ZAP70 SLA2 [activation] EIF4G1 GK [activation] RAB3IL1 RAB11A [activation] HSF1 TTC5 [activation] ZBED4 NOTCH1 [activation] RRAS ZHX2 [activation] SOCS1 FYN [inhibition] VWF HSP90B1 [activation] MSR1 HSPA1A [inhibition] CALM1 ESR1 [activation] PPP2R5B AXIN1 [activation] RSU1 LRCH3 [activation] GMPPA BTC [activation] ERC1 RIMS1 [activation] PLCG1 TUB [activation] PRR20E TOLLIP [activation] WWOX ATM [activation] F2R CAPN1 [activation] RPA1 RAD51 [activation] IKBKB NR2C2 [activation] C7orf25 RASSF1 [inhibition] SP1 CHD3 [activation] SRPK2 MPP3 [activation] NXF1 CMPK1 [activation] MCM7 DDX21 [activation] MAPK10 HDAC1 [activation] PRPF40A VCL [activation] LYN PRKDC [activation] SETDB1 HSPB3 [activation] ANAPC15 ANAPC10 [activation] FRS2 RND1 [activation] MAPK3 RCAN1 [activation] MYC LIMS1 [activation] ZXDA CIITA [activation] CRMP1 CCL18 [activation] SERPINA1 DERL2 [inhibition] TGFB1 AURKA [activation] MDM2 PC [activation] PIK3R2 GOLGA2 [activation] SIK2 HSPA2 [activation] NOTCH1 WWTR1 [activation] CDK7 PRKCI [activation] SRPK2 PRPF40A [activation] RICTOR DHRS4 [activation] JAK3 APOA1 [inhibition] 页 53 共 454


2016/4/8 19:14

EDA2R TRAF6 [activation] FKBP5 STK11 [activation] VEPH1 BMPR1B [activation] SCN8A GNAO1 [activation;inhibition] RAD21 PPP1R15A [inhibition] GNAI1 RAD52 [activation] SERBP1 KAT2B [activation] ATRX EIF4A2 [activation] SENP2 PML [activation] PTPN11 FLT1 [activation] AHNAK MDM2 [activation] APC PTPN13 [inhibition] PCBP1 HLA-B [activation] MPPED1 SPP1 [activation] CYSLTR1 CYSLTR2 [activation] FBXL19 STRADA [activation] GRIA2 SPTBN1 [activation] NCK1 FRS2 [activation] RASGRP4 RAP1A [activation] EIF2AK3 BCL6 [activation] AKAP2 CRK [activation] PRKDC IKBKB [activation] NEDD9 CRKL [activation] CDK18 HSP90AB1 [activation] LMNA GRB2 [activation] HIST1H2BL CD81 [activation] SGOL1 PPM1A [activation] MTERFD2 FOS [activation] OLFM2 RPS6 [activation] PPIG SP1 [activation] F13A1 CDKN1A [activation] SYK STAT3 [activation] ADRB2 INSR [activation] PIK3R4 YWHAG [activation] PPP1R12B PRKG1 [inhibition] EHD4 CCDC8 [activation] ICT1 MRPL37 [activation] ACTB LGALS13 [activation] HSPB1 RPAP3 [activation] PTPRG CSK [activation] MC4R PRKACA [activation] MAPKAPK2 MAPK1 [activation] MCM2 ATM [activation] TXLNA CCHCR1 [activation] EP300 PIN1 [activation] C11orf84 GRB2 [activation] COL1A2 PDGFA [activation] LRRK2 CALM1 [activation] GABARAPL1 STK4 [activation] PAXIP1 MRPL33 [activation] S100A14 SMAD4 [inhibition] IRS4 P4HA2 [activation] FOXO4 CTNNB1 [activation] FOS ATF3 [activation] GNAI3 CD59 [activation] ACVR2A BMP6 [activation] MLH1 COPA [activation] SRPK2 RSRC1 [activation] SNW1 ANXA7 [activation] BCAP31 IGHD [activation] MCM5 RAD50 [activation] GNAI3 PRKAR2B [activation] PARD3 LATS1 [inhibition] SORBS1 MLLT4 [activation] CNTNAP1 SRC [activation] RIPK1 CRADD [activation] RUNX1 SMAD2 [activation] CRY2 PER2 [inhibition] EGFR STAT2 [activation] HSPA4 ERBB2 [activation] HEATR2 ARF6 [activation] GRB2 TPM2 [activation] NFKB1 TNIP3 [activation] TAF7 HSF1 [activation] PTK2 DNM2 [activation] MAPKAPK2 ETV1 [activation] 页 54 共 454


2016/4/8 19:14

LNX2 UBE2T [activation] MPDZ HTR2A [activation] C20orf195 SSSCA1 [activation] JUN HDAC1 [activation] STK4 RASSF6 [activation] HSPA8 NFKB2 [inhibition] SRC SMARCE1 [activation] OXSR1 SMURF1 [inhibition] KLK3 SERPINA1 [inhibition] LYN CSF2RA [activation] GSK3A PRKCA [activation;inhibition] RPS6KA2 JUN [activation] NR2E3 E2F4 [inhibition] GSK3B CDH1 [activation] DDX27 OBSL1 [activation] XPO7 EGFR [activation] SSH3 ACTA1 [activation] FAM13B YWHAE [activation] TP53 BACH1 [activation] PTPRJ GHR [activation] CLDN1 WNK4 [activation] RGS6 GNB1 [activation;inhibition] CDHR2 MAST2 [activation] FGF7 COL2A1 [activation] RGS4 PTAFR [activation;inhibition] STAT6 STAT2 [activation] ADRB2 GNB2 [activation] FASTKD1 ICT1 [activation] PPFIBP1 NXF1 [activation] RRN3 TAF1B [activation] TFRC ERBB2 [activation] OTUD1 RIPK1 [activation] CDH2 PTPN22 [activation] CALM1 USP20 [activation] GHR SHC1 [activation] SHC1 APP [activation] CADM1 MPP3 [activation] TP53BP1 MYC [activation] MAPK3 CRP [activation] GSN UBE2Q2 [activation] MPZL2 ATF4 [activation] PRF1 TRIM54 [activation] CSK CBL [activation] YWHAB RASAL2 [activation] RPS6KB2 CDC5L [activation] GATA1 MED21 [activation] PTPN11 PDGFRA [activation] PPM1B CDK2 [activation] RPA1 ATRX [activation] ANXA2 TRAF6 [activation] PRKAA1 YWHAZ [inhibition] LEPR GRB2 [activation] MYC HSD17B4 [activation] KIF23 ARF3 [activation] CRY1 GRN [activation] HSPA8 RPA1 [activation] BMP2K MBP [inhibition] NFKBIA POM121 [activation] CARD11 CBLB [activation] ICAM1 RPLP2 [activation] ATF4 GTF2F2 [activation] JUP FER [activation;inhibition] RAB21 MACF1 [activation] CITED2 TFAP2A [activation] CTTNBP2NL PPP2R1A [inhibition] IL6 SH3GL2 [activation;inhibition] MTFR2 GOLGA2 [activation] SAT1 GDF9 [activation] PIN1 PLK1 [activation] MAP4K4 HSP90AB1 [activation] HSF1 CDC20 [activation] TRIP10 WASL [activation] TGFB2 FMOD [activation] INPP5K ANXA7 [activation] GRIK2 CDH2 [activation] ZC3H11A RAPGEF4 [activation;inhibition] 页 55 共 454


2016/4/8 19:14

TRIM28 MYB [activation] STX4 SNAP29 [activation] CHRND GRB2 [activation] PLD1 ACTA1 [activation] SPATA31E1 MYC [activation] HSPG2 CTGF [activation] RPL13 MAPKAPK5 [activation] BAG3 TIMP2 [activation] USHBP1 TXLNA [activation] SGOL1 RAD21 [activation] EIF4A1 CENPA [activation] PPP2R1A CTNNBIP1 [inhibition] CCDC8 JUP [inhibition] VTN LNX2 [inhibition] SAA2 COL4A1 [activation] CBLB WAS [activation] ACTB CD81 [activation] SPP1 CISD2 [activation] RHOA FAM65B [activation] FBXW5 MYB [activation] GRB2 SPRY2 [activation] RHEB TPT1 [activation] IPO7 TRAF6 [activation] MAP4K3 LCP2 [activation] NBN MDM2 [activation] PTP4A3 STRAP [inhibition] HSPB1 SPACA7 [activation] HSPA2 SRC [activation] ACVR1B TDGF1 [activation] APP AREG [activation] PPP2R5B SGOL1 [activation] APC MYO6 [activation] AR FGR [activation] RANBP9 CD4 [activation] CREBBP SMARCA4 [activation] CAV1 TNF [activation] TRAPPC10 NOTCH1 [activation] RAB10 RPA2 [activation] UNK PAX8 [activation] CDKN1A SDF4 [activation] HDAC4 CAMK1 [activation] TGFBR3 TGFB3 [activation] PIAS1 AXIN1 [inhibition] PDGFRA TGFBR2 [activation] TEK TNIP2 [activation] RASA1 BBS10 [activation] YWHAB ARHGEF2 [activation] DOCK4 EIF4A3 [activation] HYOU1 H2AFX [activation] TBK1 TICAM1 [activation] PLS3 GRB2 [activation] BTK FASLG [activation] IL12A WASF1 [activation] ACVR2A BMP2 [activation] CSF2RB MAD2L1 [activation] AURKB CIB1 [activation] GABARAP DKC1 [activation] STX1A MDM2 [activation] PZP TGFB2 [activation] ANAPC10 PTBP3 [activation] HSPB1 EIF5 [activation] PLEK THBS1 [activation] OXTR GPRASP1 [activation] PLA2G4A RELA [activation] PRKCH PTPN11 [activation] ACTB PLD2 [activation] KPNB1 RAN [activation] PAXIP1 MCM6 [activation] SMAD2 HOXD13 [activation] PLK1 TP53 [activation] HMGA2 SMAD1 [activation] PLD2 RPS6KB1 [activation] CRK HSPA8 [activation] LRRK2 EIF4B [activation] ANLN SH3KBP1 [activation] MCM4 MDM2 [activation] 页 56 共 454


RPS6KA4 FHL2 GHRL CD40 CAMP FASN APOB HSPA5 FYN EPAS1 ITGB2 FEM1B NTRK1 NUDC ZAP70 TSC2 RAP1A ACTB BEGAIN VAMP1 C1QA PSD YY1 XPO7 EGFR CIB2 NCAPD2 CEBPB PYCARD PML S100A2 OBSL1 FREM2 FGFR3 GRIA1 TICAM1 CAMKK2 SRSF3 MBD3L2 GRAP BMX IL3RA CHEK2 HSPBP1 MAP2K1 APP PPM1G GNAQ REN SHH RARA SARS BTN3A3 HDAC1 IL1R1 SYN1 GNA11 YWHAB SRPK2 TRPV4 ADCY10 TRAF6 YWHAE TNF F12 FYN MYC MAGED2 TP53 AKT1 CCDC57 ENG SYK ESR1 KPNA2 EPS8

2016/4/8 19:14

FOS [activation] FAM154A [inhibition] LEP [activation] RFC5 [activation] IGF1R [activation] OBSL1 [activation] ARFGAP1 [activation] MTNR1B [activation] DKKL1 [activation] EIF4A1 [activation] FUT4 [activation] FAS [activation] PTPRG [activation] TSSC1 [activation] LCK [activation;inhibition] SMAD3 [inhibition] RASIP1 [activation] CRK [activation] RBL1 [inhibition] VAPA [activation] DCN [activation] GLRA2 [activation] CTCF [activation] PDPK1 [activation] LGALS8 [activation] MYOD1 [activation] SOX2 [activation] SMARCC1 [activation] MYO1C [inhibition] CTNNB1 [activation] MDM2 [activation] HNRNPA0 [activation] MDM2 [activation] FGFR2 [activation] CXCR2 [activation] IRF3 [activation] SLC25A11 [activation] NXF1 [activation] POLD3 [activation] PLCG1 [activation] RUFY2 [activation] JAK1 [activation] TP53BP1 [activation] HSPA1A [inhibition] BLVRA [activation] GPR3 [activation] LRPAP1 [inhibition] RGS16 [activation] CTSB [activation] SEL1L [inhibition] SRC [activation] GH1 [activation] CTSL [activation] BUB3 [inhibition] TOLLIP [activation] GRB2 [activation] ADRB2 [activation] TNIP3 [activation] ADPRH [activation] LCK [activation] SSTR5 [activation] NHP2 [activation] CDC25A [activation] CSF1 [activation] C1QBP [activation] SH3BP2 [activation] MAPK8 [activation] CDK18 [activation] PPP2R2B [activation] RAB3D [activation] TSGA10IP [activation] ARRB2 [inhibition] RASA1 [activation] SCYL2 [activation] CREBBP [activation] CD3E [activation] 页 57 共 454


2016/4/8 19:14

IDE CCL4 [activation] VDAC3 ICT1 [inhibition] GH1 SHC1 [activation] CAV3 INSR [inhibition] REL TSSK3 [inhibition] CHUK UBE2E3 [activation] SSPO ATXN7L1 [inhibition] ULK2 PLK1 [activation] RAP1GAP CNR1 [activation] FKBPL SIM2 [activation] ENOX2 CIB3 [activation] UBE2D3 RELA [activation] REPS2 CDK1 [activation] RANBP2 SENP1 [activation] JUND BCL6 [activation] ITGB1 MMP9 [activation] BID CSNK2B [activation] MORF4L2 PALB2 [activation] AR GAK [activation] C9orf9 DDX24 [activation] HDAC1 EHMT2 [activation] FST C8orf33 [inhibition] VDAC3 IKBKE [inhibition] ANKRD11 RAC3 [activation] MYOG CDH18 [activation] YY1 MDM2 [activation] RTN4R LINGO1 [activation] INSR GRB14 [activation] CDK4 CEBPA [inhibition] FBXO5 ANAPC11 [activation] CSF1R SOS1 [activation] MAP2K1 BANP [activation] LY96 CDKN2C [inhibition] MXI1 BUB1B [inhibition] METTL13 MYC [activation] PRKCA CFTR [activation] ACTG1 MDK [activation] SKI GATA1 [activation] CDH13 RAD51 [activation] RAC1 TRAF6 [activation] NOTCH2NL EIF4E2 [activation] GH1 PTGES3 [activation] UBE2E2 HERC5 [activation] MAPK8 MAPK9 [activation] HLA-E CD8A [activation] POLR2A HMGN1 [activation] PCSK9 LDLR [activation] SETD7 RELA [activation] MAPK6 SERPINA4 [inhibition] SDCBP FOXP2 [inhibition] TRIB3 CDC25A [inhibition] SEC16A LATS1 [inhibition] MATK LYN [activation] NFATC2 YWHAZ [activation] JUNB FOSL2 [activation] PUM2 ATG5 [activation] PPARG MAFF [activation] CCDC8 GRK6 [activation;inhibition] CCAR2 IKBKE [inhibition] PALB2 IL24 [activation] ESR1 CACUL1 [activation] KIDINS220 VCAM1 [activation] CHRM3 GZMB [activation] NSD1 RXRA [inhibition] RHOV NCK2 [activation] MYC PDS5A [activation] DAAM1 B3GALT4 [activation] ESR1 ANGPTL4 [activation] EIF1B EIF2S1 [activation] PTK2 F13A1 [activation] ITGA6 ITGB4 [activation] TSSK6 HSPA8 [inhibition] GRB2 ANK2 [activation] ICT1 MRPL43 [activation] HDAC1 TWIST1 [activation] STRN PPP2CA [inhibition] 页 58 共 454


2016/4/8 19:14

SRPK2 SRSF12 [activation] LRRK2 PKM [activation] SMURF1 PRPS1 [inhibition] STAT5A TXNDC11 [activation] CYB561 EDA [activation] ARRB2 TAB1 [inhibition] YTHDC2 IRF4 [activation] IGSF21 BCR [activation] WHSC1L1 SMARCA2 [activation] GJA4 OPRK1 [activation] ACTG1 ABLIM1 [activation] CUTC PIM2 [inhibition] FDPS FGFR1 [activation] ATF2 DDIT3 [activation] LYN HSP90AA1 [activation] CNKSR1 MAP2K7 [activation] CTNNB1 OBSL1 [activation;inhibition] RAC1 ICMT [activation] OGDH NXF1 [activation] NCF1 PRKCA [activation] MYD88 SMAD3 [activation] LATS1 MARK1 [inhibition] SH2D1B SLAMF1 [activation] PRKRA RB1 [activation;inhibition] SRGAP2 YWHAG [activation] SYNGAP1 KDR [activation] CHEK1 CDKN1A [activation;inhibition] EGFR PRKDC [activation] SP1 SENP6 [activation] STK38 RICTOR [activation] CASP3 SARS2 [activation] GRB2 MAPK14 [activation] MTNR1A RAC1 [activation] YWHAZ SMARCA4 [activation] ATP13A2 F2R [activation] STAT5A MAGEA12 [activation] NOD1 NLRP1 [activation] HSP90AB1 ARRB2 [activation] BCAP31 GPRIN2 [activation] RARA RUNX1 [activation] VAV2 MET [activation] AHNAK NXF1 [activation] TRAF2 NECAP2 [activation] BCL10 ATM [activation] FYN ASAP2 [activation] MAP4K2 SERPINA4 [inhibition] PTPN14 CDH1 [activation] LGALS8 NDP [activation] SMAD4 CNKSR1 [activation] CSF3R PTPN11 [activation] CASP8AP2 TRAF2 [activation] SETD5 NXF1 [activation] LIFR PTPN11 [activation] RIMS1 LRRK1 [activation] IKBKB COPS7A [activation] GABARAP TFRC [activation] APP CXCL14 [activation] MIB1 DAPK1 [activation] CFL1 ACTG1 [activation] LRP8 SS18 [activation] LYN PAK2 [activation] PAK4 YWHAZ [activation] HSPB1 POP7 [activation] SRGAP3 TNIK [activation] IQSEC1 IRAK2 [activation] PAK2 RPS6 [activation] NR1H3 NR0B2 [activation] SMAD3 ANAPC10 [activation] POLR2C ATF4 [activation] SPRY2 CBLB [inhibition] MYOG CALM1 [activation] VCAM1 SRSF9 [activation] YY1 MECOM [activation] UBR4 AURKB [activation] SNAI1 TP53 [activation] JUN MACF1 [activation] 页 59 共 454


2016/4/8 19:14

NR1H3 CEP350 [activation] LATS1 XIAP [inhibition] NOP10 SRPK3 [activation] PPP2CA BCL2 [inhibition] TEK PTPRB [activation] UFM1 UBE2E3 [activation] HSPH1 ATF2 [activation] PLG PLAU [activation] PAX3 GRB2 [activation] DUSP3 HLA-B [inhibition] RXRA HDAC3 [inhibition] CTTN CTNND1 [activation] CDH1 CA9 [activation] P2RX4 NOTCH2NL [activation] CASP10 TNFRSF1A [activation] AR JUN [activation] MDM2 DDX5 [activation] TOLLIP CHD6 [activation] TAF1 RBL1 [activation] SIM2 NUDC [activation] PPARA PPARGC1A [activation] PTPN6 FLT3 [activation;inhibition] PPP1R14A PRKCE [activation] FYB SKAP2 [activation] PRKCB PA2G4 [activation] STX4 SCAMP5 [activation] SERPINF2 PRSS1 [activation] MAD2L1 INSR [inhibition] ITGA4 RAP2B [activation] HOXA7 MEIS1 [activation] NR1H3 MDFI [activation] HPN F7 [activation] CEP19 AK4 [inhibition] STAT3 TRIP10 [activation] ELK1 MAPK11 [activation] SCRIB PHLPP1 [activation] NDRG1 BCL2L11 [activation] NCOA1 NCOA3 [activation] DVL1 RASSF10 [inhibition] PXN BCAR1 [activation] TLR4 TLR1 [activation] EGFR HSP90AB1 [activation] PDCD6 FAS [activation] TNF NFKBIA [activation] SGOL1 PRKDC [activation] GDF15 MDFI [activation] MDM2 CSNK1E [activation] ZFYVE9 CHD6 [activation] TRAP1 MDM2 [activation] IGF2 TF [activation] TWF2 NELFCD [activation] ITGA4 STMN1 [activation] PRDX5 ICT1 [activation] ANAPC1 UBE2S [activation] MAPK1 SUPT20H [activation] NXF1 CKAP4 [activation] ACVR1B BAMBI [inhibition] ANXA7 GNB2 [activation] DES ATF2 [activation] GAK CCNG1 [activation] DNAJA2 TP53 [activation] STMN1 PRKACA [activation] TP53 G3BP1 [activation] ATR DCLRE1C [activation] FGF3 EBNA1BP2 [activation] ANKRD28 RAD21 [activation] GCC1 GLI1 [inhibition] SHB JAK3 [inhibition] GMFB TRAF6 [activation] DYRK1A SH3GL2 [activation] AKAP12 EGFR [activation] CRY2 CSNK1E [activation] SNW1 RAD50 [activation] SRF SMAD7 [activation] MCM7 HIST3H3 [activation] NUDCD3 KLHL34 [activation] 页 60 共 454


2016/4/8 19:14

YWHAG YAP1 [activation] RPL19 ICAM1 [activation] RPS6KA1 YWHAB [activation] PRKCB TNFRSF1A [activation] IGHM CTR9 [activation] BRAF MAPKAPK3 [activation] E2F3 SP1 [activation] IL17RD MAP3K7 [activation] GRIA4 SDCBP [activation] MOB1A LATS1 [inhibition] EEF1D TRAF6 [activation] TCOF1 RPA3 [activation] STAT1 DUSP3 [inhibition] MAPK1 CEP55 [activation;inhibition] DLGAP5 GOLGA2 [activation] PPARGC1A ESRRG [activation] NOS3 ST13 [activation] SCRIB PRKCA [activation] SRPK1 FLOT1 [activation] SUMO4 PGK1 [activation] PHLDA3 WWC3 [activation] CCNA2 KAT2B [activation] STK3 PTPN14 [activation] RPA2 ANXA2 [activation] ICT1 ECH1 [activation] PIAS2 TSR2 [activation] IKBKG EPHA4 [activation] PCNA FOXO3 [inhibition] CDC25C PIN1 [activation] MAPK6 PVRL2 [activation] UBA5 CBR1 [activation] BCR YWHAH [activation] CASP1 FGF2 [activation] GM2A PLD2 [activation] NCOA3 PGR [activation] MYD88 CISH [activation;inhibition] POLD3 POLD1 [activation] A2M MAST1 [inhibition] APP KCNK5 [activation] GCG FAP [activation] RIPK3 CASP8 [inhibition] PPP2CA PPP2R3B [activation] TGFBR1 TRAF6 [activation] KLHL23 CDKN1A [activation;inhibition] CREB3 PSENEN [activation] DGKD TNFRSF14 [activation] CD4 PTPRC [activation] CDC42 TP53 [activation] CSK DAB2 [activation] HSPA2 MEPCE [activation] NFKB1 E2F1 [activation] BTK PLCG2 [activation] MLH1 SPERT [activation] MAPKAPK2 SMNDC1 [activation] ERBB2 CRKL [activation] KSR1 VRK2 [activation] SRC SORBS1 [activation] RASGRP3 PRKCE [activation] EIF4E MTOR [inhibition] FYN DLGAP1 [activation] GNL3 WHSC1 [activation] RPL6 ICAM1 [activation] AURKB FKBP5 [activation] PPARG TFAP2A [activation] NOTCH1 FBXW7 [activation] IKBKB NLRC5 [activation] RPA2 STAT3 [activation] TRAF3 MAP3K14 [activation] GIMAP5 LSMEM2 [activation] EPHB3 MLLT4 [activation] PRRT2 SNAP25 [activation] RAC1 PAK7 [activation] NRTN GFRA2 [activation] NUDCD3 KLHDC10 [activation] VCAM1 STRAP [activation] CDH13 PTPN1 [activation] 页 61 共 454


2016/4/8 19:14

FGF7 COL6A1 [activation] NUP133 SEH1L [activation] TP53BP2 TP53 [activation] ARRB1 CCL14 [activation] TTK CDC16 [activation] TCP10 APP [activation] FECH MME [activation] CEBPA UBTF [activation] SNRK HSPA1A [inhibition] RHEB BRAF [activation] SUMO3 LRPAP1 [inhibition] GARS TRAF6 [activation] PARP8 YWHAB [activation] TRAF1 ACTG1 [activation] TP53 LYN [activation] TMC5 NUMBL [inhibition] OXT ESR2 [activation] PLCG2 PRKD1 [activation] GADD45A NRBP1 [activation] BTRC BTG2 [activation] CASP9 GMEB1 [inhibition] MAPK8 SH3BP5 [activation] CSF2RB YWHAZ [activation] RAPGEF2 SPP1 [activation] RAP1GAP CSNK1G2 [inhibition] CENPA DIAPH1 [activation] NUDC HCFC2 [activation] RASL12 APP [activation] RXRA RELA [inhibition] CCNE1 POLD1 [activation] DNM2 DDX39B [activation] LUC7L FAM173A [activation] RPA4 APP [activation] ACAD8 ETS1 [activation] RPL24 ICAM1 [activation] HSP90AB1 JAK2 [activation] EXOC7 HGS [activation] PRKAR2A ARFGEF2 [activation] RRAD CALM1 [activation] TXNIP TP53 [activation] GRIA4 CAMK2A [activation] LYN PPP1R15A [inhibition] HLA-B LAGE3 [activation] SMC2 SNW1 [activation] RASSF1 SKP1 [inhibition] YWHAE VASP [activation] LMX1A BMPR2 [activation] CEBPB HOMER3 [activation] MDM2 MGEA5 [activation] SGTA SPP1 [activation] CS HSPB1 [activation] SH2D1B PECAM1 [activation] AURKB SEPT1 [activation] CFTR GNA11 [activation] TIMM50 TNFRSF10B [activation] APOE PLEKHA6 [activation] GNAI2 KRT40 [activation;inhibition] CDK6 CDK2 [inhibition] RPA3 CHD4 [activation] EHD4 PHLDA3 [activation] NCOA3 ARNT2 [activation] BMP4 BGN [activation] FBXL21 CRY1 [inhibition] CAPN10 FLOT1 [activation] LGALS9 JUP [activation] ASS1 MT2A [activation] TRAF3 TNFRSF11A [activation] ADRB2 JKAMP [activation] IGFBP5 SPP1 [activation] NCAM1 PPP1CA [activation] HIST3H3 AIRE [activation] CD4 HSPA8 [activation] CD81 PCBP2 [activation] TTC28 SSPO [inhibition] PAK2 SH3PXD2A [activation] SH2D1A SLAMF6 [activation] 页 62 共 454


2016/4/8 19:14

SMARCA2 KAT2B [activation] CAMKK2 SMC1A [activation] MAPK9 MACF1 [activation] AURKA NME1 [activation] MYOD1 CALM1 [activation] YES1 MST1R [activation] E2F1 CUL1 [inhibition] GNA12 TEC [activation] F2 AKR7A2 [activation] YWHAE MYC [activation] STK11 RPS6KA3 [activation] LRP6 FZD8 [activation] MPZL1 PTPN11 [activation] FOXA2 EN2 [activation] RAB2A GOLGA2 [activation] GCN1L1 ILK [activation] RELA GCN1L1 [activation] MAPK1 ICK [activation] NFKBIA SUMO1 [activation] PTPN1 CSNK2A1 [activation] CDC6 MYC [activation] CTNNBIP1 CDH5 [inhibition] WDR65 FOS [activation] HCK ABI1 [activation] TLR1 TLR2 [activation] ERCC6 MDM2 [activation] VASP WASL [activation] BCL6 PIN1 [activation] KLF5 WWTR1 [activation] NCOA3 SUFU [activation] BTRC CTTN [inhibition] GTF2A2 HSF1 [activation] PECAM1 ITGA5 [activation] PTK2 UBE2H [activation] FAM57A MAPK4 [activation] IGFBP4 LRP6 [inhibition] PPP3R1 TP53 [activation] IL23A HERPUD1 [activation] DLX4 ABL1 [activation] BTRC IGF2BP1 [activation] USP7 RASSF1 [inhibition] STK3 MBP [activation] CCDC8 YTHDC2 [activation] RAN NUPR1 [activation] RAP1A FTSJ1 [activation] HSPA9 MAP3K7 [activation] RPL36 GRB2 [activation] PTK2B CD2AP [activation] CASP3 AIFM1 [activation] CXXC1 OGT [activation] TNFRSF8 TRAF2 [activation] DCC EIF4E [inhibition] ILK PNKD [activation] RPL14 TP53 [activation] TXNRD1 TXNDC17 [activation] SMAD4 TCTA [activation] SRPK1 TULP2 [activation] PHLDA3 RUNX1-IT1 [activation] ATF4 NFKBIA [activation] TRAF6 IL17RB [activation] ATF2 S100A2 [activation] TGFBR1 ANAPC5 [activation] CELA1 A2M [inhibition] ITGA4 HSPD1 [activation] CCDC8 GRN [activation] SOX2 RUNX1 [activation] BEX1 GSK3B [activation] AFF4 SPP1 [activation] ITGB3 CAPN1 [activation] DDX54 ESR1 [activation] ARF1 OPRM1 [activation] ABL2 ABL1 [activation] GSPT1 TRAF6 [activation] JAK2 PPP2CA [inhibition] MTOR PML [activation] FOXO1 CCNB1 [activation] 页 63 共 454


2016/4/8 19:14

CKAP4 ATF4 [activation] BUB1B SGOL1 [inhibition] ARRB1 ARPC5 [activation] PPM1B CHUK [activation] RPL27 ICAM1 [activation] MRPS34 ICT1 [activation] BMPR1A TGFB1 [activation] RAP1A HSPA1A [inhibition] AKT1 MAPT [activation] ITGA1 FABP3 [activation] MAPKAPK3 AURKA [activation] FAM20C PROP1 [activation] GOLGA2 MOS [activation] PDE1A APP [activation] MAGEB2 RARA [activation] MOS SPERT [activation] DDX39A UBA5 [activation] ARF6 ARRB2 [activation] PHLPP1 PHLPP2 [inhibition] FXR2 PRKAA1 [inhibition] LARP1 ESR1 [activation] YWHAG DDX17 [activation] CDC7 ORC1 [activation] ITGB2 ITGAL [activation] CASP3 YWHAE [activation] CD2 LYAR [activation] GRPEL1 ATF2 [activation] CCDC57 CWF19L2 [inhibition] DAPK3 LINC00846 [activation] JAK3 GTF2B [activation] BCAR1 EFS [activation] KATNB1 EIF4A2 [activation] ANXA8 APP [activation] ARHGEF6 PRKDC [activation] GNAO1 ADORA1 [activation;inhibition] MVP PTPN11 [activation] ACVR2B FSTL1 [activation] LAMA5 MYOC [activation;inhibition] MAPK1 SH2D3C [activation] GNA11 MTNR1A [activation] TNFRSF11B TNFSF13 [activation] ERBB2 BAAT [activation] PTK2 TSC2 [activation;inhibition] TP73 PAX6 [activation] ULBP2 PDGFRA [activation] CDKN1C CDK2 [inhibition] UBC RHOA [activation] TCEB2 SOCS2 [inhibition] RPS8 ICAM1 [activation] CEBPB SMARCA2 [activation] CCND2 RUNX1 [activation] ADAMTSL4 VCAM1 [activation] HSP90AB1 IRF3 [activation] GRB2 STAMBP [activation] AR GRB7 [activation] IFIH1 IKBKE [inhibition] UGT1A1 UGDH [activation] DAZAP2 CTNNB1 [activation] NOTCH1 EPN1 [activation] YWHAZ CYR61 [activation;inhibition] MSH6 MAP2K1 [activation] ACTB ANXA7 [activation] SRC DLX4 [activation] PPARGC1A NR3C1 [activation] ANAPC11 NKD2 [inhibition] GNA15 GRM4 [activation] MBP MAPK15 [activation;inhibition] PRNP RPL41 [activation] MAPKAPK2 CDC25A [activation] GEM TRIM23 [activation] MYC ACACA [activation;inhibition] SRGAP1 BMPR1B [activation;inhibition] FBXW11 CDC25B [inhibition] EIF2S1 RPA2 [activation] RHOB NQO2 [activation] PFN1 ESR1 [activation] 页 64 共 454


2016/4/8 19:14

RFC2 DDX11 [activation] CDH2 PTPRO [activation] ULK1 NTRK1 [activation] ATF2 TUBB [activation] CDC37 TRAF6 [activation] MAP2K5 ASRGL1 [activation] RAC3 CIB1 [activation] MAPKAPK5 PLA2G4A [activation] FBP2 STK11 [activation] GNAI1 TSHR [activation] MRPS30 ICT1 [activation] MDM2 RAN [activation] EIF4A3 HNRNPH2 [activation] KLRC1 PTPN6 [activation;inhibition] CBL SHC1 [activation] GRB2 WDR77 [activation] GRB2 CCM2L [activation] PARVB STK4 [activation] ARHGEF7 HSPB1 [activation] PIAS2 C1QA [activation] MAML2 NOTCH2 [activation] ITGA4 RAB10 [activation] MAPT BIN1 [activation] ETS1 SMARCA2 [activation] PPP1CA CDH1 [activation] SRPK2 CD53 [activation] CCDC88C APP [activation] ACTG1 MDM2 [activation] VWF SOCS4 [inhibition] NCK2 LRRIQ3 [activation] AHNAK GRB2 [activation] EFHD2 LRRK2 [activation] MAP1LC3B SNCA [activation] SMAD4 BTRC [inhibition] EPOR ATXN2L [activation] EZR DCC [activation] IRS4 CRK [activation] CDK2 POLD1 [activation] DOK2 SSSCA1 [activation] SPANXN4 SRPK1 [activation] ICT1 MRPL1 [activation] PTPN2 JAK3 [inhibition] BCAR1 TNS1 [activation] SMAD3 PAX8 [activation] OGFOD1 HLA-B [activation] CTNNB1 IKBKB [activation] NOTCH1 ANAPC7 [activation] LATS2 MOB1A [activation] LRPAP1 POLA2 [inhibition] TGFBR1 OXSR1 [inhibition] DDX5 SMURF1 [inhibition] APP CAMKV [activation] RRAGA RRAGD [activation] EEF2K BTRC [activation] SRPK1 LCE3D [activation] TP53 MNAT1 [activation] REV3L MAD2L1 [activation] MAPK13 SMAD4 [activation] ICT1 MRPL3 [activation] GALNT12 PIK3CA [activation] GAS7 ABI1 [activation] CSNK1D MDM2 [activation] KCTD20 PPP1CC [inhibition] NFATC2 PIN1 [activation] PXN NEDD9 [activation] STK3 VAPA [activation] TP53 TTLL5 [activation] HCFC1 HSPA1A [inhibition] PPP1CC C9orf50 [inhibition] PLCG2 GRB2 [activation] SLC25A6 MAP1LC3B [activation] UBC F12 [activation] GNAI2 MCF2 [activation] ARNTL SIRT1 [activation;inhibition] SNRPA1 ARF6 [activation] DNAJA1 NFKB2 [inhibition] 页 65 共 454


2016/4/8 19:14

TWIST1 HOXA5 [activation] GSK3B PPARGC1A [activation] ARAF HSPB1 [activation] SETD8 LEF1 [activation] DHX34 RPS6KA6 [activation] RAD21 CTSG [activation] HSF1 SUMO1 [activation] SKP2 CDC20 [inhibition] LCK PRKACA [activation] HMBOX1 CCNG1 [activation] EP300 GOLGA2 [activation] RUNX1 HIPK2 [activation] CDKN2A CDC14B [inhibition] FYN HEXA [activation] TGFB1 BMP3 [activation] TFRC CD9 [activation] SMAD9 DNAJA3 [inhibition] LYN GTPBP3 [activation] PRKAR1B WNK1 [activation] NFKBIA RPS6KA1 [activation] TAF8 MEF2A [activation] SRPK1 PPIA [activation] BLK BCAS2 [activation] SFXN1 UBA5 [activation] HSP90AA1 JAK2 [activation] RGS2 LRRK2 [activation] PAXIP1 PRPSAP1 [activation] KMT2E CDK1 [activation] PIN1 ITGA4 [activation] HIST3H3 SFMBT1 [activation] LARS YWHAZ [activation] GADD45A DNAJC13 [activation;inhibition] RCHY1 F7 [activation;inhibition] TUB JAK2 [activation] PER3 PER1 [inhibition] TFRC EGFR [activation] PAXIP1 LARP1 [activation] APP MDM2 [activation] CCNH RPA1 [activation] NANS TLR2 [activation] GRIP1 EFNB2 [activation] CDC42BPB RIPK1 [activation] THOP1 STK11 [activation] PTMA HSPA1A [inhibition] HOXB4 EP300 [activation] SUMO3 BUB3 [inhibition] GRIP1 EFNB1 [activation] PFDN1 INPP5K [activation] CSNK1D CCNA1 [activation] CTSS PLCG1 [activation] PARD6B CRB3 [activation] TYK2 DNM2 [activation] DDR2 SRC [activation] FYN FAS [activation] RNF4 UBE2E3 [activation] PAK2 SH3KBP1 [activation] MLLT4 YWHAZ [activation] DENND2C LYN [activation;inhibition] CDC27 HOXC10 [activation] RAN TNPO1 [activation] PRKACB RCAN1 [activation] EPHB1 GRB7 [activation] CSNK1A1 CTNNB1 [activation] PAXIP1 SMC2 [activation] CBL OSTF1 [inhibition] SNTA1 KCNA4 [activation] AKAP7 PRKACA [activation] NCOA1 PRMT2 [activation] PLCG1 SHB [activation] ACTG1 ANXA5 [activation] BCL2L11 AURKA [activation] DOCK8 CDC5L [activation] ACTB ACTR2 [activation] SRPK2 TLE4 [activation] TNFRSF1B TRAF6 [activation] HDGF MAPK14 [activation] 页 66 共 454


2016/4/8 19:14

WBSCR16 ICT1 [activation] CDK2 CDK3 [activation] U2AF2 MDM2 [activation] NOS1 HMOX1 [activation] INS LRP2 [activation] LAS1L MYC [activation] ELAVL1 RUNX1 [activation] CUL2 BCL2L11 [activation] FYN IL7R [activation] ITGB1 EPS8 [activation] BTK TLR9 [activation] CBL SH3BP2 [activation] PPP2R2D PPME1 [activation] ASAP1 ARAP3 [activation] CDC25B KRT35 [activation] MDM2 HNRNPL [activation] DCC RPS24 [activation] OBSL1 DKC1 [activation] PRPSAP1 PRPS1 [inhibition] FGFR2 MTA3 [activation] HMGB1 PRKCA [activation] IL3 BCR [activation] SIRPA JAK2 [activation] YTHDF2 EPAS1 [inhibition] ENO1 TNS3 [activation] IGF1R PTPN1 [activation] CSK YTHDC1 [activation] FZR1 EYA1 [activation] MDM2 DAAM2 [activation] SERPINB1 ELANE [inhibition] PPP2R4 AURKB [activation] CAV1 POU3F3 [activation] LIN37 E2F4 [activation;inhibition] STAM SORT1 [activation] MAPK9 ACP5 [activation] RHEB RPS6KB1 [activation] ITGA4 RAC2 [activation] ICAM1 SRP14 [activation] MIF STRN4 [activation] HSP90AA1 CDK15 [activation] SPTAN1 EVL [activation] CACNA1S YWHAQ [activation] EIF4G3 LGR4 [activation] CAP1 ACTG1 [activation] MATK PXN [activation] ABL2 MAP3K10 [activation;inhibition] PRKCD MACF1 [activation] GORASP2 CDC23 [activation] MAPRE1 TROAP [activation] THSD7A SKIL [activation] FAN1 PCNA [activation] NFE2L2 CDKN1A [activation] AREG MMP9 [activation] MAP4K5 NCK1 [activation] CPNE6 MAPK11 [activation] ADAP1 GADD45A [activation] ERCC6L CDC5L [activation] ATP1A1 CFL1 [activation] AURKB CDCA8 [activation] GRB2 ARHGAP12 [activation] RPL26 MTOR [activation] GNG3 GNB1 [activation] FBXO6 EIF4A1 [activation] FLI1 UBE2I [activation] VCAM1 MYL12B [activation] PRKRA SHC1 [activation] HSPA8 PARD3 [activation] THBS1 CTSG [activation] EIF2S1 LYAR [activation] PAG1 PRKCB [activation] ELMO1 TRIM54 [activation] CALM1 STIM2 [activation] PIK3R1 INPP4A [activation] AKT3 PRKCZ [activation] PTGIR PDZK1 [activation] ECT2 PPP2CA [activation] 页 67 共 454


2016/4/8 19:14

CD4 LAT [activation] PAK1 BAIAP2 [activation] HLA-B TTLL12 [activation] RPS6KB1 EIF4EBP1 [activation] EIF1B RPA3 [activation] PTPRT PTPRN [activation] MDM2 FARSA [activation] SRF ELK1 [activation] RAVER1 VCL [activation] PIK3R1 PTK2B [activation] APPL1 DYSF [activation] PIK3R1 ZC4H2 [activation] THRB NSD1 [activation] ECT2 RHOG [activation] IRS4 CCDC8 [activation] KCNA5 PRKCQ [activation] HSPB1 MSL1 [activation] E2F5 CREBBP [activation] DYRK2 HIST3H3 [activation] FYB PLCG1 [activation] HSP90AA1 DAPK1 [activation] CYTH3 INSR [activation] SNX17 GRB2 [activation] PLXNA2 UBAP2L [activation] GRB2 HSP90AB1 [activation] TP53 NUAK1 [activation] CYCS ITGA4 [activation] MLH1 ANXA2 [activation] SKP1 FBXL21 [inhibition] TERF1 YWHAG [activation] IDE GCG [activation] HIST3H3 JAK2 [activation] TIMM50 EGFR [activation] GRB2 RPL27 [activation] RASA1 HCK [activation] SELL GRB2 [activation] FBXO25 ACTG1 [activation] ACTA1 AIF1 [activation] CRK REPS1 [activation] NFKBIA UBE2E3 [activation] PTPN11 STAT1 [activation] ADRA1B ADRA1A [activation] CHUK TAX1BP1 [activation] COCH COL4A1 [activation] PYCR1 VCAM1 [activation] SRPK2 DGCR8 [activation] XCL2 NOTCH2NL [activation] ACTA1 RPS6KB1 [activation] ILK RPL13 [activation] DCTN1 MAPT [activation] PTPN18 ABL2 [activation] PUM1 EIF5 [activation] DDAH2 RPS6KA1 [activation] MYC IQCE [activation] YWHAG ZAK [activation] DLGAP1 CRK [activation] SGK1 IGHG1 [activation] EPHA3 RUFY2 [activation] AURKB SGOL1 [activation] RND3 SKP2 [activation] EIF2B4 EIF2B5 [activation] BRD7 DVL1 [activation] SRC SH3KBP1 [activation] TNFSF11 AKT1 [activation] CALM1 HTR2C [activation] RABGEF1 MAPK1 [activation] RAP1B DDAH2 [activation] FRAT2 EGFR [activation] HSP90AA1 SRPK3 [activation] RAF1 RSU1 [activation] SH2B1 MET [activation] SRC STX17 [activation] H2AFX ARRB1 [activation] PAK2 AK2 [activation] HIST2H2AC AURKB [activation] LEF1 SMAD7 [activation] 页 68 共 454


2016/4/8 19:14

IGHG1 FCGR3B [activation] ADAMTS2 PIK3R5 [activation] MAP2K4 TRIB1 [activation] SCGB1A1 LMBR1L [activation] PIM1 HIST3H3 [activation] HCLS1 ACTR3 [activation] HSPA1L GRB2 [activation] DESI1 FGF7 [activation] EIF3L CD81 [activation] CDH1 CFTR [activation] GAPDH PLD2 [activation] SUV39H1 DBF4B [activation] EIF4A1 EIF4G1 [activation] EMILIN1 SRPK1 [activation] PRIM1 TP53 [activation] CCT8 SMURF1 [inhibition] SH2D2A ERBB2 [activation] SHC1 PLCG2 [activation] MYC LATS1 [inhibition] ETFB ADRB2 [activation] MDM2 GNAS [activation] CLINT1 AURKB [activation] RYR1 HOMER2 [activation] FLOT1 FRS2 [activation] CD19 BTK [activation] SMAD4 RHOD [activation] STRA13 FANCL [activation] NAT9 LUC7L2 [activation] IRAK1 IKBKB [activation;inhibition] MET PTK6 [activation] HIST1H2AD VCAM1 [activation] CASP9 ILK [activation] NCOA1 HNF4A [activation] COL6A1 PDGFB [activation] TOP2A PRKDC [activation] CCNA2 PGR [activation] TNF LYN [activation] MYOG MAPK3 [activation] KAT2A TP53 [activation] CRTC1 EP300 [activation] YWHAH KIF23 [activation] PPP1R14A YWHAZ [activation] PICALM EHD2 [activation] ALK MAP3K4 [activation] HLA-B FKBP3 [activation] MEIS1 TLX3 [activation] HAUS7 ATF4 [activation] NUP62 NCAPG [activation] MEF2A ASCL1 [activation] CHUK MAP3K11 [activation] ERCC1 UBL7 [activation] IKBKB EGLN3 [activation] TIRAP MPP3 [activation] CMTM6 DUSP10 [inhibition] WIZ EHMT1 [activation] NXF1 PXN [activation] AK2 MDM2 [activation] WNK1 MPHOSPH9 [activation] BMP4 TWSG1 [activation] TP53 NEIL3 [activation] TAF1 CLIP4 [activation] ESR1 MVP [activation] FYN TRPC6 [activation;inhibition] CDK4 HSPA8 [inhibition] GSK3B RSU1 [inhibition] RGS4 EGFR [activation;inhibition] ANGPTL4 SMARCA4 [activation] DNAJA1 SHC1 [inhibition] CKS1B FZR1 [inhibition] PPBP EFNA1 [activation] PAK2 PPP2R2B [activation] ARRDC4 ARRB2 [inhibition] LRRK2 ATP5O [activation] CYTH1 PRKCD [activation] CD3D KCNA3 [activation] PAK4 YWHAG [activation] 页 69 共 454


2016/4/8 19:14

NR2C2 TRAF2 [activation] NEDD9 FYN [activation] ZFYVE27 APP [activation] GAPDH CCNB1 [inhibition] HCK HSP90AA1 [activation] RCHY1 MDM2 [activation;inhibition] ZBED1 PRKAA1 [inhibition] NAV2 RRAS [activation] GABARAPL2 HSPA4 [activation] NRXN2 MACF1 [activation] IGHG1 ELN [activation] NCK1 MET [activation] PPP2R1A SGOL2 [inhibition] AZGP1 STK4 [activation] EIF4A3 BOLA2 [activation] YWHAE MAP3K2 [activation] MLH1 STAP2 [activation] CDK18 CDK5 [activation] JAK3 CDK1 [activation] EHMT2 PML [activation] PIK3R1 EXTL3 [activation] CSF2RB JAK1 [activation] TRAF2 IQUB [activation] FBXO4 TERF1 [activation] IGFBP5 FHL2 [inhibition] CDK11B YWHAB [activation] SCYL2 CDC5L [activation] STXBP6 STX1A [activation] TCOF1 UBTF [activation] PRKDC ASB5 [activation] TFCP2 MAPK1 [activation] CTBP1 BMPR2 [activation] COL4A2 SERPINE2 [inhibition] IKBKE DDX58 [inhibition] USP33 RALA [activation] RSBN1 PAX8 [activation] SMAD4 RHOG [activation] CCDC151 SUV39H1 [activation] WWTR1 DVL1 [activation] CTNNB1 SOX6 [activation] TIRAP TICAM1 [activation] SDC2 LAMA3 [activation] NGB GNAO1 [activation;inhibition] ETV5 AMH [activation] SLC9A1 ARRB1 [activation] CAPN2 CAPNS1 [activation] LYN SKAP2 [activation] EGFR RIN2 [activation] MYC MFHAS1 [activation] ILF2 MRE11A [activation] PNRC2 SPAG9 [inhibition] NFAM1 SYK [activation] FYN DOCK3 [activation] ATM MTA3 [activation] IGF2 NOV [activation] DDX56 MRPL43 [activation] ETS1 AR [activation] PLEKHM1 MAPK6 [activation] FAM105B FAM168A [activation] AGPAT6 NXF1 [activation] ZNF106 WNK1 [activation] UBE2I ATF3 [activation] TP53 MYL9 [activation] CAD YWHAZ [activation;inhibition] ATR RPA3 [activation] CAMK2D FAM171B [activation] HYOU1 ESR2 [activation] ROBO2 NR1H2 [activation] PRKACA GPR161 [activation] KCNK15 YWHAB [activation] TRAF1 TNFSF9 [activation] ASB2 HMGB1 [inhibition] CSH1 SMAD4 [activation] MYC IQGAP3 [inhibition] HSP90AB1 NXF1 [activation] HES6 CREBBP [activation] 页 70 共 454


2016/4/8 19:14

CAMLG TRAF5 [activation] FBXO5 NXF1 [activation] TBXA2R RAB11A [inhibition] APP DNAJC4 [inhibition] PRDX2 PPP2R1A [inhibition] UGT1A7 PRKCE [activation] LCK LIME1 [activation] SRPK1 SPAG11B [activation] RAP1GAP BRAF [activation] HSP90AA1 PRKCB [activation] CSNK1E FARP2 [activation] KCNA2 PTK2B [activation] GAPDH GADD45A [activation] ARHGAP1 RAC1 [activation] RAC3 RARA [activation] TNFRSF13B TRAF6 [activation] GSTK1 RAB3GAP2 [activation;inhibition] GRB2 HTRA1 [activation] ARFGEF2 SNW1 [activation] TFRC LAPTM4A [activation] STAT5A BRCA1 [activation] HRAS TLR9 [activation] BUB3 ZNF207 [inhibition] TRIM69 ASNS [activation] CHRDL2 BMP4 [activation] CDK2 CDK13 [activation] NR4A1 HSPH1 [inhibition] SUMO1 EPAS1 [activation] PTK2 PTAFR [activation] OLIG2 EP300 [activation] AURKB MAPRE2 [activation] SPRR1A EGFR [activation] PANX1 CASP3 [activation] BAAT CTNNA1 [activation] OTUD4 ILK [activation] RPA3 HNRNPL [activation] ADRB2 RHOD [activation] EIF2B2 C9orf72 [activation] PLG EP300 [activation] SNAP25 APP [activation] HES1 JAK2 [activation] GRB2 PAG1 [activation] FOXA2 GSC [activation] EP300 HERC1 [activation] RXRA ACVR1 [inhibition] ENO2 HSF1 [activation] ACVR2A TGFBR3 [activation] ACTB RPA3 [activation] PRKAA1 YWHAE [inhibition] DOK4 RET [activation] MAP2K3 SPAG9 [inhibition] HSPA1A PRKCA [activation] GNAO1 OPRD1 [activation] JUNB C19orf68 [activation] RCHY1 BIRC3 [activation;inhibition] TRAF2 BANP [activation] ERBB3 PIK3R2 [activation] NOTCH2NL WDR25 [activation] PTGES3 NR3C1 [activation] IGHM OR5H6 [activation] TRAF2 NIF3L1 [activation] HMGA2 XRCC6 [activation] GABRR1 BCR [activation] CAPN1 FANCA [activation] TMSB4Y ACTG1 [activation] EP300 MAGED1 [activation] ERBB4 CFL1 [activation] MAPRE2 PAXIP1 [activation] HOXC6 FGFR2 [activation] ISL2 LHX3 [activation] PPP2R5A TP63 [activation] HDAC3 CCND1 [activation] VCAM1 MARS [activation] GUCY2D FYN [activation] HSPA8 LGALS3BP [inhibition] GNAQ VIPR1 [activation] 页 71 共 454


2016/4/8 19:14

PML FOXO1 [activation] CLIP4 CMYA5 [activation] VCAM1 PRKDC [activation] CXCL1 HIPK2 [activation] TRIM28 IRF1 [activation] NCK2 FAM53C [activation] F2R MMP1 [activation] MCM7 MYC [activation] ATM PPP2R4 [activation] CCR2 CCR5 [activation] HSPH1 VAV2 [activation] VAV1 INSR [activation] TLE4 PPM1B [inhibition] S100A4 TP53 [activation] INHBA INHBB [activation] VAC14 PPP2CA [inhibition] PPP3CC BCL2 [inhibition] CSF1R RASA1 [activation] HDAC1 RELA [activation] BHLHE40 CALML3 [activation] TOLLIP FAM115A [activation] CCNA2 CDH2 [activation] TNF HNRNPD [activation] WDR6 MAP2K7 [activation] UBTF IRS1 [activation] CERS2 ARHGEF7 [activation] PTPN5 MAPK1 [inhibition] FOS SPI1 [activation] CASP7 PLA2G4B [activation] GPHN PCK1 [activation] GRB2 SNTA1 [activation] RPS6 PCK1 [activation] BARD1 GNPAT [activation] RAC3 NCL [activation] TNFRSF1A SYK [activation] GAB2 PTPN6 [activation] TOLLIP DIABLO [activation] HSD17B4 GABARAP [activation] ITPR2 CCDC8 [inhibition] OBSL1 CDK1 [activation;inhibition] S1PR5 GNAI1 [activation] KIT FYN [activation] NCOA2 TBK1 [activation] PDGFRA SHF [activation] RPA2 MYO1F [activation] MDM2 NME1 [activation] CREB5 ATF2 [activation] CDC42 SH3D19 [activation] PPP3CB MYOZ2 [inhibition] TP53 RPL21 [activation] PRKACB TRAP1 [activation] COL2A1 PDGFA [activation] GATA1 ZZZ3 [activation] SMAD3 TRIB3 [inhibition] TERT NCL [activation] PGM3 LRRK2 [activation] EIF2AK2 NLRP3 [inhibition] SERPINB6 CEP170P1 [inhibition] FAM71C NOTCH2NL [activation] GPR56 ADRB2 [activation] FGB MIS12 [activation] LDB2 ISL1 [activation] MARK3 CAPZB [activation] NR3C1 RAN [activation] RANBP2 NLK [activation] SOS1 SHC1 [activation] RAD21 PRKDC [activation] PXK HNRNPA0 [activation] SMC4 IKBKG [activation] NSD1 ZNF496 [activation] PRIM2 YWHAZ [activation] CCNG1 PLEKHA4 [activation] MYD88 PELI1 [activation;inhibition] SRC CD33 [activation] HSP90AB1 PPARG [activation] PIK3R1 TPSB2 [activation] 页 72 共 454


2016/4/8 19:14

CRK HSPA1L [activation] TBK1 TLR3 [activation] APP CSNK1G1 [activation] HLA-E KLRC2 [activation] SOCS3 NFKB1 [activation;inhibition] ATF2 CTTN [activation] PRKCA IBTK [activation] ISYNA1 PPP2CA [inhibition] ABI1 SOS2 [activation] TP53 E2F1 [activation] ANXA3 ATF2 [activation] AREG CCND3 [activation] EIF2AK2 TRAF2 [activation] MAPK1 PPM1A [activation] APPL1 HSPB1 [activation] APP CASP4 [activation] IRS1 CDH1 [activation] FES IRS2 [activation] LCE1B RGS20 [activation;inhibition] ATP5F1 SPP1 [activation] TBP TAF1 [activation] UBE2M TP53 [activation] SP1 CD2 [activation] PIN1 NFKBIA [activation] KMT2B CRK [activation] DDX18 INADL [activation] CFHR5 C3 [activation;inhibition] IGHG1 SERPIND1 [inhibition] FASLG PIK3R1 [activation] RAPGEF2 KIF5B [activation] PPP1CA RPRD2 [inhibition] PKN2 CASP3 [activation] ZFC3H1 MYB [activation] GABARAPL2 CDC5L [activation] ACTG1 SCIN [activation] CYFIP1 ABI1 [inhibition] KMT2A SKP2 [activation] EGFR TTI1 [activation] SMAD2 DGKA [activation] SLC8A1 PPP3CB [inhibition] STK4 FLG [activation] SYK MAP4K1 [activation] CDH18 CDH6 [activation] CXorf27 MYOG [activation] APP CAMKK2 [activation] EIF2S1 VCAM1 [activation] DNA2 RPA3 [activation] ARRB2 SPIN3 [inhibition] NSL1 LRRK2 [activation] ADCY5 PRKCZ [activation] PELI2 IRAK4 [activation;inhibition] E2F3 CREBBP [activation] GNL3 SRPK3 [activation] APP LDLRAP1 [activation] CPE BDNF [activation] FCHSD1 DNM2 [activation] MAP2K1 AURKA [activation] SERPINB13 PRTN3 [inhibition] NUDT5 TRAF6 [activation] PPP1CA AKT1 [activation;inhibition] C7orf50 PAXIP1 [activation] MAP3K12 RGS1 [activation;inhibition] PTMS EP300 [activation] MAGEA1 HLA-B [activation] TGFBR1 TSSK4 [activation] KRIT1 NXF1 [activation] TP53 IFRG15 [activation] RAB2A RPA1 [activation] COMMD10 NFKB1 [activation] YWHAQ KIF23 [activation] MELK MBP [activation] CRTC2 PPP3CA [activation] PPP1CA ENO2 [activation] GSN MAP1S [activation] HDAC1 PITX2 [activation] TGFB3 CTGF [activation] 页 73 共 454


2016/4/8 19:14

APC PCNA [inhibition] LSM3 ICAM1 [activation] HIST1H4A PRMT7 [activation] PHLDA3 VAMP7 [activation] YWHAB LSR [activation] APOC1 IGHG1 [activation] PXN ILK [activation] YWHAQ SSH1 [activation] FOS EEF1D [activation] HSPB1 GATA1 [activation] SRF SUMO1 [activation] APP MPP3 [activation] CSNK1E USP9X [activation] PIK3R1 ZAP70 [activation] PSD GNAQ [activation] NCK1 KIT [activation] LLGL1 PRKCZ [activation] CENPJ RELA [activation] FBXO43 CDC27 [inhibition] BCL6 FOXM1 [activation] A2M TNFRSF14 [inhibition] GRB2 GCDH [activation] NR1H4 RXRA [inhibition] SP1 GABPA [activation] USH1C ANKS4B [activation] TYK2 VAV1 [activation] GDF5 ACVR1 [activation] NCK1 MAP4K1 [activation] HSPA8 MDM2 [activation] PPP1R9A RPS6KB1 [activation] INSR SOCS6 [inhibition] PMS1 MLH1 [activation] LCE3E RGS20 [activation;inhibition] MYH2 PTK2B [activation] PIAS1 GLUL [inhibition] G3BP2 RPF2 [activation] CLTCL1 EGFR [activation] SMAD9 CTR9 [activation] DYSF ANXA1 [activation] IRAK3 ECM1 [inhibition] LRRK2 PRPF6 [activation] CCDC8 SMC2 [activation] YAP1 YWHAH [activation] YAP1 CDH3 [activation] ESR1 SUV420H1 [activation] NCDN EFHC2 [activation] RNF165 SMAD7 [activation] RAC1 PRKCI [activation] CXCR4 B2M [activation] SRPK1 CAMK2D [activation] EIF2AK2 CASP7 [activation] DIAPH3 MYC [activation] LYN HSP90AB1 [activation] BLZF1 GEM [activation] MT-RNR2 BCL2L1 [activation] EIF3F SGK1 [activation] HSPB1 MME [activation] STAT1 E2F1 [activation] FOXJ1 RPUSD1 [inhibition] MAPRE3 AURKB [activation] GNAI1 PGR [activation] RPA1 HNRNPA0 [activation] TWF2 CAPZA1 [activation] ASAP2 PTK2B [activation] RAC1 PAK3 [activation] CAPZB GABARAPL2 [activation] PTPN6 PTPRC [activation] FYN ABL2 [activation] TICAM1 TRAF5 [activation] CDC23 BCAS3 [activation] CCL1 CCR8 [activation] TRAF6 IL1RL1 [activation] NEK8 HSP90AB1 [activation] KCNC1 KCNC2 [activation] RAD51 ATRX [activation] PPP1R14A CSNK1G3 [activation] 页 74 共 454


AREG COL1A1 CTNNB1 SCAP MAVS B4GALT1 DET1 JAK2 MLH1 RFXANK CDC25C PIK3CA HRG VASN YWHAE RASSF9 EP300 HOXD10 FBXW11 FRS3 FBXW4 NUP155 NFKBIA SKP2 PMAIP1 PRKCG CREBBP EP300 EGFR NXPH3 SHC1 CDK5R1 TMEM147 RARA YTHDF1 PTPN7 PPP2R1A GABBR1 PAXIP1 ECSIT CAD PIP5K1A CDKN1A RAF1 SH3RF3 IDE SMAD4 RB1 MAVS HSPA4 OPRD1 APP SFXN1 JMJD6 ACVR1B JUN YWHAG STK4 EIF2AK2 PRKCB GRB2 APC USP7 XPO1 AR PTPN11 VCAM1 SMAD1 FBXL5 MSANTD3 HDAC4 TP53 PTEN RIF1 SEH1L NAV1

2016/4/8 19:14

S100A5 [activation] FGF7 [activation] CCND1 [activation] INSIG1 [activation] ECSIT [activation] CDK11A [activation] MDM2 [activation] PPP2R1B [activation] VAMP8 [activation] BSG [activation] YWHAZ [activation] TICAM1 [activation] CHRD [inhibition] PSEN1 [activation] HSPA8 [inhibition] DVL3 [activation] PDHX [activation] CREBBP [activation] RELA [inhibition] RFX6 [activation] PPP2R1A [inhibition] HLA-B [activation] TBK1 [activation] RAG2 [activation] GSK3B [activation;inhibition] DDX58 [activation] IFNAR2 [activation] DEK [activation] TRIM29 [activation] SRC [activation] FCGR1A [activation] NOTCH2NL [activation] CASP4 [activation] SUV39H1 [activation] RPA2 [activation] APP [activation] KLHL15 [inhibition] GRB2 [activation] NCAPG [activation] SMURF1 [inhibition] CASP3 [activation] CADPS [activation] CDK5R1 [activation] INSR [activation] RAC1 [activation] IGF1 [activation] CD59 [inhibition] HIST1H4A [activation;inhibition] TMEM173 [activation] HIF1A [activation] PRKCD [activation] PDPK1 [activation] HLA-B [activation] RSPO2 [inhibition] HSP90AA1 [activation] STAT1 [activation] SSFA2 [activation] IQGAP2 [activation] CDC42 [activation] RASGRP3 [activation] DOCK1 [activation] ANKRD17 [inhibition] RELA [activation] EGFR [activation] PIAS2 [activation] ITGB3 [activation] STAT5B [activation] RAC2 [activation] SMURF1 [inhibition] CDH1 [activation] CTNNB1 [activation] DNMT1 [activation] USP10 [activation;inhibition] TDGF1 [activation] RPA2 [activation] APC [inhibition] 页 75 共 454


2016/4/8 19:14

PRKDC SP1 [activation] ANAPC1 HECW2 [activation] PPP1CC JAK2 [inhibition] RARA NSD1 [activation] WAS NCK2 [activation] NXF1 COMMD9 [activation] CEBPB SRF [activation] GNB2 GNAI2 [activation] APOL5 FYN [activation] NRIP1 HDAC1 [activation] LCP2 PTPRC [activation] ICAM1 RPS28 [activation] WASF2 PRKACA [activation] ICT1 PUSL1 [activation] CYTH1 ARF6 [activation] CLEC4A PTPN6 [activation;inhibition] RPA2 ACTB [activation] CBL LTK [activation] KAT2B SERTAD1 [activation] CTBP2 ACTG1 [activation] PTPRD EGFR [activation] STAT3 GNB2L1 [activation] MAP2K3 ALDOC [activation] MORC3 KPNA2 [activation] SRF BARX2 [activation] RTEL1 RPA3 [activation] WNK1 ZYX [activation] PPP2R1A PPP2R2C [activation] PRKCB IBTK [activation] KCNG1 HSP90AB1 [activation] HLA-B SMAP [activation] NOXO1 NOXA1 [activation] GK RXRA [inhibition] PRKCE ITGB1 [activation] MYO1C RPA1 [activation] CDC27 FBXO5 [inhibition] CDK6 TJP2 [inhibition] EGFR OXSR1 [activation] TLR3 TAB2 [activation] PAG1 SLC9A3R1 [activation] NSMCE2 RAD21 [activation] SAV1 STK3 [activation] KIDINS220 NTRK3 [activation] PPP1R12A TP53 [activation] GRB2 PPP6R3 [activation] TRIP6 CNTF [activation] OXSR1 PAK1 [activation] MAP1LC3B ACTB [activation] PPP2CA GABARAP [activation] DDX21 CTNNBL1 [activation] IGHG1 FCGR2B [activation] PRKCA TIAM1 [activation] CDK11B TPPP [activation] CSNK2A2 MAPK14 [activation] IRAK2 SMAD2 [activation] TAF1 HMGB1 [activation] SNAP91 PLCG1 [activation] DAB1 SERF2 [activation] SH3KBP1 PAK1 [activation] ATG5 CNN3 [activation] ARPC3 EFTUD2 [activation] GNAQ GNB3 [activation] TSC1 MAPK14 [activation;inhibition] RPA3 SMC2 [activation] MLST8 A2M [inhibition] STAT5A ESR1 [activation] PCSK1 IAPP [activation;inhibition] FN3KRP EGFR [activation] CDSN GABARAPL2 [activation] SMAD4 EIF4A3 [activation] PCNA SETDB1 [activation] GMFB CSNK2A1 [activation] POLR2A KMT2A [activation] TMEM173 IFIT1 [activation] MLLT4 PVRL1 [activation] GPC1 TDGF1 [activation] 页 76 共 454


2016/4/8 19:14

CCR5 TXK [activation] LRP1 MBL2 [activation] PXN VCL [activation] RPS19 GABARAPL2 [activation] BCAR3 ERBB2 [activation] MBL2 PTPRC [activation] FGF3 FGFR1 [activation] STK11 COPS4 [activation] TSTD2 EGFR [activation] APP NRIP1 [activation] USP7 RARA [activation] SPEG PRMT1 [activation] ACTA1 GAS7 [activation] PLCG1 TGOLN2 [activation] SGK1 HNRNPL [activation] TMPRSS11A MYC [activation] RARA PRKDC [activation] EIF4A3 STK38L [activation] PSEN1 ECSIT [activation] TFRC ATF2 [activation] PTPN1 RHOBTB2 [activation] DDX60 EGFR [activation] GSK3B TPPP [activation] HLA-C BATF2 [activation] GABARAPL1 MIF [activation] NR1H2 COL4A5 [activation] CASP3 TGM2 [activation] SENP1 PML [activation] EED EHMT1 [activation] BID CRNKL1 [activation] CMTM3 SPP1 [activation] PIK3R5 CXCL2 [activation] TSSK3 HSP90AB1 [activation] MAPK6 CYTH2 [activation] KIFC2 TAB1 [inhibition] WAS ABI3 [activation] MOV10 CDH24 [activation] TNFRSF25 TNFRSF1A [activation] APP CDK3 [activation] UBTD1 FZD5 [activation] PTK2B PITPNM3 [activation] ABL2 CASS4 [activation] MEOX2 PAX1 [activation] CAMSAP1 SKIL [activation] APP TWF1 [activation] PTEN CXCL1 [activation] RAC1 PTPLAD1 [activation] EGFR TXN [activation] GORASP2 MAPK8 [activation] MAP1B SNCA [activation] RIT1 GRB2 [activation] VAMP7 AP3D1 [activation] STK4 MCM4 [activation] SRPK1 ILF3 [activation] TNFSF10 RIPK1 [activation] EXOC4 SPAG9 [inhibition] ARF6 MICALL1 [activation] RELA SRF [activation] LIN54 RB1 [inhibition] CACNA1D CALB1 [activation] MYC KPNA2 [activation] IL2RB JAK2 [inhibition] WWP1 NOTCH1 [activation] BCR FES [activation] DCLRE1C BRCA1 [activation] SRPK2 SDR42E1 [activation] AKT1S1 RPS6KA5 [activation] DYRK1A CCDC8 [activation] THAP1 OGT [activation] CEP250 HSPA8 [inhibition] TGFBR1 ARHGEF6 [activation] CDKN2A MAPK8 [activation] PRNP FAM27E3 [activation] RANBP2 TP53 [activation] MYC DHX15 [activation] CRK GRIP2 [activation] 页 77 共 454


2016/4/8 19:14

CHD4 ATR [activation] UBE2I CDCA8 [activation] DYNLRB1 BCL2L11 [activation] PPFIA3 PPP2CA [inhibition] RPS6KB1 BTK [activation] NUP62 DGCR6 [activation] GPR158 MYC [activation] PARD3 IGHA1 [activation] CXCL5 DARC [activation] GAB1 VAV1 [activation] CASP3 MEF2A [activation] EIF1 EIF3C [activation] CDH1 TGM2 [activation] TGFBR1 CDC20 [inhibition] SH2D2A SMAD3 [inhibition] LEF1 E2F1 [activation] SUMO4 PAFAH1B3 [activation;inhibition] HBG2 APP [inhibition] RB1 MAPK8 [activation] ABL1 LRRK1 [activation] FASTKD2 TRAF6 [activation] PRKCA GFPT1 [activation] PARD3 SMAD2 [activation] EIF3F EIF4A2 [activation] DKKL1 CRK [activation] UBXN11 ZFYVE9 [activation] DDX46 SRPK2 [activation] PLN EDA [activation] TWSG1 BMP1 [activation] SCRIB OBSL1 [activation] NUP98 NUP88 [activation] MCM2 CDK4 [activation] BMP7 MTUS2 [activation] RELA KAT2A [activation] MDM2 TTF1 [activation] SMPD1 CASP7 [activation] RXRB CACNA1B [inhibition] UBC DLX5 [activation] PRSS1 GRB2 [activation] CCNG1 LTBP3 [activation] ECT2 PGAM5 [activation] DVL3 HOMEZ [activation] ZNF282 MAPKAPK5 [activation] MAST2 GCN1L1 [activation] SETDB1 HMOX2 [activation] NXF1 C9orf40 [activation] YWHAB MLK4 [activation] TRA2A SRPK2 [activation] CFL1 SMURF1 [activation;inhibition] CD247 NSUN5P2 [activation] MCM3 OBSL1 [activation] PLK1 RNF126 [activation] ELANE SERPING1 [inhibition] KIF23 PPP2CA [activation] CAV1 KCNA5 [activation] CD247 LAT [activation] HTT EHMT1 [activation] CDC42 DEF6 [activation] MAP2K4 RBBP8 [activation] GNRHR2 GNRH2 [activation] CLIP1 MAPRE1 [activation] PPARG CTNNB1 [activation] MAPKAPK2 HNRNPA0 [activation] GRN ELANE [activation] SRCIN1 BCAR1 [activation] EIF2S3 METAP2 [activation] XPO1 E2F5 [activation] PRKDC TOP1 [activation] NXF1 GRHPR [activation] TPP1 EGFR [activation] EP300 KCTD5 [activation] CREBBP UBE2I [activation] MAPK14 TCEAL1 [activation] RPL35A GABARAPL2 [activation] GEM RNF7 [activation] TOP1 KMT2A [activation] 页 78 共 454


PARP2 NCK2 PLA2G4A CASP4 PPP3CC ATF2 CFP SP1 NLRC4 PTPRK CD33 PIN1 EIF2A SMAD7 CES1 RPTOR MEP1A ZKSCAN8 NGFR EHMT2 PIK3R1 VAPA FYN AGFG1 CMYA5 GEM WNT4 RELA RHOC CDK4 PDGFA MARCKS SVEP1 TOLLIP ACTG1 USHBP1 RADIL ATF6 TNRC6A PAXIP1 CHEK1 DAPK2 NUMB CTNNB1 JAK2 NSMCE2 ARHGEF6 BHLHE40 EDARADD ARRB1 MYC MAP3K3 PAX6 CDK5 ARFGEF2 CDH1 PTPRJ RAB8A SBK1 HSPH1 HSD17B3 PRKACA ATXN10 MEPE PDIA5 PPP1CC RAPGEF1 CLTC SH3GL2 TFRC CSF1R BRAF MLLT4 OPRM1 NR4A1 FASLG

CTNNB1 IRS1 MYC NUP93 BMPR1B SSFA2 C3 MAPK3 EIF2AK2 MAPK3 CBL PTPN1 APP EP300 GUSB FBXO9 POMC PRNP NDNL2 SUV39H1 PLCG2 GPR128 TULP1 ITGA4 DYSF TRIM54 P2RX4 BARD1 GH1 BMPR1B PDAP1 MAPK13 SKIL IL1RAP RIPK2 DYDC1 GNB1 NFYC PRNP NUPR1 SETMAR MLC1 PRKCA DDX5 FGFR1 SMC5 CAPNS1 BRD7 ATG5 MAPK14 ARF1 PPP2R5A HIPK2 CDK5R2 GABRB2 YAP1 ERBB2 RAB10 TRIP10 CFTR CDH1 SI PHLDA3 GRB2 NXF1 HSPA2 HCK RAC1 TIAM2 TRAF6 ITGAV TERF1 SSX2IP GNAI1 PPM1A ARHGAP9

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[activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] 页 79 共 454


RICTOR AKT1S1 NTRK3 HTR2A GADD45G LUC7L CREBBP LDLR APOL1 IGHM MTPN RELA HSPB1 ANXA1 MEFV PSTPIP1 PPP2R3B MYC NFYA HDAC1 KIF7 SAV1 MAP2K2 CNKSR1 YWHAG TIAM1 SCAMP1 TP53 MCM3 CCL2 ATP6V1B1 HEATR2 EGFR TGFBR2 TGFB2 IL1R2 IL1RN GRN POT1 TP53 KLF6 MAGEA11 NR3C1 NUMB DPYSL2 CTSB SRPX2 CREBBP DDIT3 STAT5A TCF12 SH2B3 EGFR HSP90AB1 CDK6 MCM2 RAB11FIP5 GPR78 APP GNAQ S1PR2 H2AFX TRAP1 RBPMS FOXP3 AFF1 PCSK1 CAPN1 BCL2L1 SRSF10 SFN MYO1F RPA1 FLAD1 ANXA7 GNAI2 ITCH C5orf30 MAPK7 ARRB1 DVL1 MAP3K14 MAP3K7 PDPK1 PTPRJ ERBB3 DAB1 TP53 MRPS18B CEBPB STAT5A FHL2 SMAD3 CORO2B VCL CNTROB LATS1 VTN PVR EGFR HEATR3 PTPRU GNAI1 RAD1 RPA1 PLK1 RAP1GAP HSPB1 EPB41L3 TPD52 TPD52L1 EIF2S1 PRKCA COL4A1 SMAD1 NEDD8 CASP7 SENP1 TP53 CCNE1 RBL1 PTGIR ADCY10 PSIP1 CASP3 SIPA1L3 FMNL1 CDKN2A RIN2 PRKAR1A TAB1 HIF1A MAFG FBXO6 YTHDF2 BMPR2 TGFBR1 MAPK14 NFATC1 NXF1 CALM1 FANCG FAN1 YWHAB TTC28 PTPRM CDH1 RELA SAT1

2016/4/8 19:14

[activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] VAMP7 [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] MAP4K2 [activation] [activation] ARF6 [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 80 共 454


2016/4/8 19:14

KPNA1 IL1RAP [activation] HSPB1 TTC3 [activation] CAMKK2 PRKDC [activation] ABI1 MRFAP1L1 [activation] PPP3CA ATP2B4 [activation] RPA3 RAD52 [activation] NGF SORT1 [activation] BCR TP53 [activation] RAB5C RPA2 [activation] GSK3A HSF1 [activation] ANXA2 PRKCA [activation] AFG3L2 EGFR [activation] TEAD4 WWTR1 [activation] PRPSAP1 PLEKHF2 [inhibition] OR8D2 IGHG1 [activation] RELA OGT [activation] CD5 PRKCB [activation] PTF1A RBPJ [activation] SOCS2 MET [inhibition] SUGT1 NOD1 [activation] SFRP4 PIK3CA [activation] KRAS FRAT2 [inhibition] PLEKHG5 RND1 [activation] BMPR1B PAK1 [activation] GABARAPL2 ATG16L1 [activation] ACTB TMSB4X [activation] KDM6A GATA4 [activation] TOP2A H3F3A [activation] STAT3 SMAD1 [activation] SNRNP70 SMAD4 [activation] DNM1 CDK5 [activation] SYK TRAIP [activation] IL27RA IL27 [activation] ACOT9 EGFR [activation] WNK1 YWHAG [activation] TOP2A SRPK1 [activation] BAG3 ATG7 [activation] GPN1 RPAP2 [activation] GNAI3 GNB1 [activation] ICAM1 RPS15 [activation] RPS6KA4 SNW1 [activation] STMN1 HSPA8 [activation] CDKN1A DOCK7 [activation] DDA1 PRKAA1 [inhibition] ITGA4 LONP1 [activation] YWHAQ RASGRP3 [activation] GABARAP ATG10 [activation] RUNX1 PAX5 [activation] MYBL2 LIN54 [inhibition] FAM98B SGK1 [activation] NUSAP1 APP [activation] ATF1 GABPA [activation] NEDD9 LYN [activation] CDK7 CCNA2 [activation] CHRM4 GRB2 [activation] TRAF3 SRC [activation] CTR9 IGHG1 [activation] CDKN3 NCOA3 [activation] AHCYL2 TRAF6 [activation] PIK3C3 YWHAG [activation] TP53 CALD1 [activation] MYC SMC2 [activation] NBN RBBP8 [activation] HMGA2 UBC [activation] CTBP2 EHMT2 [activation] CFH ADM [inhibition] MYF6 CSRP3 [activation] RAF1 KRAS [activation] SELPLG BACE1 [activation] PRKCE FYN [activation] RTCA ARF6 [activation] YWHAZ IQGAP1 [activation] CDKN2B KIAA1377 [activation;inhibition] TJP1 RAPGEF2 [activation] TP53 ERCC3 [activation] APP IL26 [activation] 页 81 共 454


2016/4/8 19:14

PTK2 JAK2 [activation] TRAP1 SMAD4 [activation] CDH24 CTNND1 [activation] ANKRD11 NCOA3 [activation] IKBKB YWHAB [activation] MAP3K14 BIRC3 [activation;inhibition] HIF1A UBE2I [activation] MAST3 PTEN [activation;inhibition] RICTOR DHX36 [activation] SUMO1 EIF4G1 [activation] STAT1 GNB2 [activation] MAPKAPK2 LYAR [activation] RPA1 EGFR [activation] EIF4E2 USHBP1 [inhibition] XIAP RIPK1 [activation] MAPK1 IFNAR1 [activation] MAPK3 CDC23 [activation] CALM1 TRDN [activation] PHACTR2 PIK3R1 [activation] INSIG1 RNF139 [activation] EGFR PIN4 [activation] PIAS1 CREB1 [inhibition] PINX1 RHOC [activation] STAT1 BCL3 [activation] EGFR MCM5 [activation] NCOA2 HNF4A [activation] NME1 NME3 [activation] ABI2 VASP [activation] RCAN1 CAPN1 [activation] HSPA8 YWHAZ [inhibition] ZFYVE9 PPP1CC [activation] SORCS2 BDNF [activation] FBXO6 PPP1CC [inhibition] ARHGEF5 GRB2 [activation] XPO7 RAN [activation] APCDD1 WNT3A [activation] PRKCA GLI3 [activation] KMT2E MYB [activation] PINX1 MIF [activation] CTNNA2 PPP2R1A [activation] NFYA ATF2 [activation] EXTL3 SRC [activation] CCNE2 RBL2 [inhibition] OGT PSG1 [activation] CD44 TRAF6 [activation] SMURF1 ING1 [inhibition] TRAF6 KCTD12 [activation] RPA2 SMC2 [activation] KCTD17 RAPGEF2 [activation] TP53 BLM [activation] IL1RL1 MYD88 [activation] GNAS GCGR [activation] CYCS VHL [inhibition] NXF1 ZRANB1 [activation] STAT1 ATF3 [activation] DUPD1 TRAF6 [activation] CSF2RB FYN [activation] SEMA6A EVL [activation] NFIL3 AMOTL2 [activation] PPP2R5D CDC25C [activation] VDR POU1F1 [activation] CDK1 RPA1 [activation] ARHGDIA TNFRSF10B [activation] MAGI3 DSCAML1 [activation] RIF1 HMGB1 [inhibition] KSR1 PPP2R5B [activation] SMARCD1 TP53 [activation] PRNP MARK4 [activation] BCL6 WDR35 [activation] USP50 HSPA8 [inhibition] CD81 EIF3C [activation] SMARCE1 GATA1 [activation] PCDH10 NCKAP1 [inhibition] PTK2B UBC [activation] TNFAIP2 ERBB2 [activation] IL24 CHEK2 [activation] 页 82 共 454


2016/4/8 19:14

HIST1H3A GRB2 [activation] DGKE NUDC [activation] CREB3 BCL2L1 [activation] CALM1 ATF2 [activation] PLK1 MYC [activation] TBP HMGB1 [inhibition] TGFBR1 RASL12 [activation] SUFU BTRC [activation] GH1 STRAP [inhibition] WAS RAC1 [activation] ADAM10 MAD2L1 [activation] GAB1 LYN [activation] HRAS BUB1 [activation] HSPE1 FTSJ1 [activation] MAP2K1 HRAS [activation] HIST1H3A SIRT1 [activation] CCL5 IL8 [activation] TAB2 TNF [activation] CDK6 MEF2D [inhibition] TPD52L1 MAP3K5 [activation] MYB MAF [activation] SATB1 CTNNB1 [activation] MAPK3 PTPRG [activation;inhibition] TNFSF11 MMP7 [activation] GRB2 PRKAR1A [activation] TP53 STRA13 [activation] PTGES3 CASP3 [activation] MACF1 GOLGA4 [activation] FASN MAPK13 [activation] TSPAN10 ADAM10 [activation] LCK ABI1 [activation] GNAI2 MTNR1A [activation] GABARAPL2 HNRNPA0 [activation] CSNK1D APP [activation] ERBB2 CHN1 [activation] TLR2 PIK3R1 [activation] TRAF2 ACTG1 [activation] CD81 HIST1H2BH [activation] PPP2CA IRAK1 [inhibition] LRRK2 PLK1 [activation] EGFR GABARAPL2 [activation] GABARAPL2 JUP [activation] TNFSF11 EZH2 [activation] STX5 SEC22A [activation] SUMF2 ZFYVE9 [activation] TBK1 APP [activation] AKT1 PTPN1 [activation] ZFPM1 TOP3B [activation] BAX BCL2L1 [activation] C6orf165 TP73 [activation;inhibition] ZBTB22 GATA1 [activation] CBLB TRAF6 [inhibition] CCND1 MAPK11 [activation] YWHAG CPSF3 [activation] CBL PDGFRA [activation] ARRB2 SAG [inhibition] RPS6KA1 GBP2 [activation] HSP90AB1 MKNK1 [activation] SIRT1 SMAD7 [activation;inhibition] LATS1 VPRBP [inhibition] NMI STAT3 [activation] TP53 TFDP1 [activation] HOMER3 GRM5 [activation] SPRR2A YES1 [activation] SCAMP5 STX6 [activation] RAB5A RAB7A [activation] F9 F8 [activation] RAC1 BCR [activation] FAS UBA7 [inhibition] CRK FASLG [activation] ANAPC1 ANAPC4 [activation] DDIT3 FOS [activation] CFP CFB [activation;inhibition] FYB VASP [activation] HSP90AB1 CRK [activation] HSPG2 FGFR3 [activation] 页 83 共 454


2016/4/8 19:14

GATA4 MEF2C [activation] CSDE1 HLA-B [activation] MYC FOXP1 [activation;inhibition] SERPINA1 SSR1 [inhibition] TICAM2 TIRAP [activation] NXF1 CAPRIN1 [activation] SP1 CABP1 [activation] NR3C1 SLC25A4 [activation] PPP2R1A MAPK6 [inhibition] SPNS1 BCL2L1 [activation] CCDC22 FAM21C [activation] PTEN PDGFRB [activation] CAMK2A ATF1 [activation] ACVR2B BMP10 [activation] ASNS IKBKE [activation] WNK1 FAM53C [activation] TMEM239 SENP2 [activation] CD81 HNRNPA1 [activation] HMGB1 CSNK1A1 [activation] ZDHHC17 STK3 [activation] EBNA1BP2 TP53 [activation] ZAK YWHAZ [activation] MAX HSP90AB1 [activation] NCKIPSD FYN [activation] MMP13 COL2A1 [activation] JUN HHEX [activation] PRKCD HABP4 [activation] TNC NCAN [activation] SDCBP EFNB2 [activation] GSN ESR2 [activation] ACACA UBE2N [activation;inhibition] WDR24 RAE1 [activation] CREBBP PPARGC1A [activation] CD3G NR3C1 [activation] YWHAZ CDK18 [activation] PARP2 IL21 [activation] ICT1 RARS2 [inhibition] SETDB1 TRIB3 [activation] PTK2B VAV1 [activation] TCEB1 WNT7B [activation] CDH1 PSEN1 [activation] IRF1 IRF8 [activation] BNIP1 BCL2L1 [activation] CDKN1A CHGB [activation] WHSC1L1 RAD51 [activation] ALKBH3 SRPK2 [activation] LRP1 GTPBP1 [activation] CBL PRPSAP2 [inhibition] HNRNPK TP53 [activation] COPB1 IRAK3 [inhibition] ESR1 SRPK1 [activation] TRIM28 EGFR [activation] CD81 HIST1H1D [activation] FGA FGB [activation] EFNB1 CCDC8 [activation] ASB7 VCL [activation] RARA RXRB [inhibition] RANBP9 ADAP2 [activation] SERPINC1 PLG [inhibition] PIAS2 TP53 [activation] ST14 CDKN2C [inhibition] STX1A CDK5 [activation] GABRG1 GABARAP [activation] EIF4E2 UBXN11 [inhibition] AATF MAPT [activation] MAPRE3 JUN [activation] LCK ADAM10 [activation] MYL12B DAPK3 [activation] APPL1 ANKRD1 [activation] IL1RAP SIRPA [activation] GPN1 HSP90AB1 [activation] CTNNB1 PTPRG [activation] NCOA1 CREBBP [activation] RAC1 CSN2 [activation] NRGN GLP1R [activation] AMOTL2 CYTH4 [activation] 页 84 共 454


PTPN11 IL4R ACTB CAV1 CDKN2A CCNG1 LYPD3 ERBB2 GPR1 GNAI1 RAB4A CDK1 ZRSR2 SRPK1 CSNK2A1 PRNP SRC CFL1 BCL6 KIF13B BRAF KSR2 RHOA KCTD13 NOTCH2NL PPP2R1A PPP2R4 FAS APAF1 DTX3 UBE2E2 ASAP1 FYN FAM208B KCTD9 RPRD1B RPA2 BCL2L13 PLLP PPP2CA MST4 ITPRIP ITPR1 GRB2 NCL IL6R JAK1 SKIL UBE2I EPS15 FYN YES1 MET DKC1 MAPK6 COL7A1 MMP2 MAPK1 IER3 LDHAL6A LRRK2 PIK3R2 CCR5 CTSL IGHA1 NOP2 PAXIP1 TFDP1 CDK6 RASA1 RAP1A JAG1 CALR HSP90AB1 PTPRC IRS1 WASF2 PRPF40A EDA GIMAP5 RCBTB2 UBE2E3 FTSJ1 OXSR1 TRIB3 TIAF1 VCAM1 LYPLA2 MET PLXNB3 ATRIP RPA1 MAP4K2 MAP3K11 WNT2 WNT3A XRCC3 RAD51 GRB2 PPP1CA UTP14A RGS1 IL18 CASP4 NFE2L2 WAC MARK3 DLG5 GLI2 HDAC1 HIST1H3A EGFR LRRK1 HMMR BRCA1 ASB17 HSPB1 RAC1 UNKL SPAG9 MYC UBTF RB1 NGRN E2F1 DDX39B HIPK2 LRRK2 RPL17 RBCK1 TNF TFDP2 LIN9 VPS35 TRAF6 SRGAP2 YWHAZ DYSF MYOM2 CAMK2B CAMK2A TNFSF11 KHDRBS1 FGF2 CXCL13 HIST1H3A DDX5 AURKA

2016/4/8 19:14

[activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] ITGB2 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] TTI2 [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [inhibition] RAD51B [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] FGF14 [activation] [activation] 页 85 共 454


2016/4/8 19:14

FHL1 SRPK1 [activation] CASP3 MLH1 [activation] STK11IP TLR4 [activation] HIST2H2AA3 GRB2 [activation] TNFRSF1B RIPK1 [activation] GJA5 PRKACA [activation] GNB5 RGS11 [activation;inhibition] GIT1 TRIB3 [inhibition] MTMR4 SMAD3 [activation] WAS PLCG1 [activation] DNM1 PRNP [activation] SMAD2 MYO18A [activation] KPNB1 SMURF1 [inhibition] CCND1 EP300 [activation] ICAM1 HIST3H3 [activation] SPP1 MAP1A [activation] CCDC180 SRC [activation] ADRBK2 ADRBK1 [activation] ITGA4 RAB5C [activation] FDFT1 ANXA5 [activation] BPTF SMARCA1 [activation] UGT1A4 UGT1A1 [activation] NUP214 DDX19B [activation] MAPK14 SMAD7 [activation] PPP1CC PPP1R15B [inhibition] YES1 VCAM1 [activation] GOLGA2 LINGO1 [activation] CDK2 SKP1 [inhibition] RPA1 BUB3 [activation] PIK3C2A YWHAB [activation] NR0B1 AR [activation] TIMM50 IKBKB [activation] ESR2 SPRR1B [activation] EIF2S2 UPF1 [activation] CXXC1 EP300 [activation] A2M ADAM19 [inhibition] PRKCB GRM5 [activation] IRF7 TRIM28 [activation] SYK ERBB3 [activation] PAK2 GRB2 [activation] ENAH ABI1 [activation] ATP13A2 AAK1 [activation] FANCM FAAP24 [activation] TRIB1 MAP2K7 [activation] SRF NCOA1 [activation] MLLT4 SMAD2 [activation] EPHB2 NUP153 [activation] DDX21 OBSL1 [activation] PTPN11 FCRL3 [activation] CACNA1S SRI [activation] EP300 ASH2L [activation] PTPN11 KIR2DL5A [activation] PRDX1 GRB2 [activation] SMC4 SMYD2 [activation] HLA-C ADRB2 [activation] TNFSF11 MMP3 [activation] YWHAZ HSPH1 [activation] FBXO6 PTPRC [activation] CXCL9 PTPN5 [activation] LAS1L FOS [activation] SMAD2 ROCK1 [activation] PTPRC EZR [activation] PML NR4A1 [inhibition] LUC7L CTNNBL1 [activation] PTTG1 CDK1 [inhibition] CHGB UBTF [activation] SMURF1 USP45 [inhibition] ELAVL1 MAP2K7 [activation] FGFR1 HSP90AA1 [activation] ACSBG1 APP [activation] MARCKS ATF2 [activation] PACSIN3 SBK1 [activation] NXF1 CHD8 [activation] MAPK12 MAPT [activation] BAIAP3 BAI1 [activation] STX4 STXBP4 [activation] 页 86 共 454


2016/4/8 19:14

CD84 ABL2 [activation] EVI5L SRPK2 [activation] YWHAH RASSF8 [activation] EIF2A ATF4 [activation] ITGB2 PRKCD [activation] NRD1 TP53 [activation] STAT1 NMI [activation] HNF4A SMAD2 [activation] CBL ITGA4 [activation] PIK3R1 ABL1 [activation] NME7 MAP4K4 [activation] PKNOX1 MEIS2 [activation] PKNOX2 FOS [activation] LRP1 BACE1 [activation] CHD4 VCAM1 [activation] C2orf44 CSNK1G1 [activation] CACNA1H PPP3CB [activation] RPA3 C7orf50 [activation] COL1A1 DDR2 [activation] STAT3 HIC1 [activation] PAM KALRN [activation] CAD MAP3K7 [activation;inhibition] MYC ACACB [activation;inhibition] CORO1C TP53 [activation] ICT1 MRPL22 [activation] FZR1 BTRC [inhibition] ECHS1 TIMP2 [activation] CCHCR1 MAD1L1 [activation] EZR YWHAZ [activation] ATF3 DBP [activation] ABI2 ARMC7 [activation] TRIP10 CDC42 [activation] CDX2 CREBBP [activation] FGFR2 BEX1 [activation] PLCB3 SLC9A3R1 [activation] STK10 CD81 [activation] DFFA BAK1 [activation] PTK2B CBL [activation] MAPK9 DUSP16 [inhibition] CLNS1A LRRK2 [activation] ARHGAP12 SRPK2 [activation] CREBRF CD2BP2 [activation] BTN1A1 PLK1 [activation] DNAJA3 MET [inhibition] NUP93 ILK [activation] EIF4E CYFIP1 [inhibition] VAMP8 USP8 [activation] CACNA2D3 RAD51C [activation] MAPK14 MKNK2 [activation] DHX57 DDX56 [activation] ROR2 MAGED1 [activation] NF2 LATS1 [inhibition] RANGAP1 EGFR [activation] SNRPD2 GRB2 [activation] HSPB1 MRPL40 [activation] SHC1 GAB2 [activation] CBL HSPA4 [inhibition] BCAR1 CBL [activation] FOXO1 SMAD3 [activation] VCL TLN1 [activation] ATF4 GOLGA1 [activation] EGFR DHRS7B [activation] TYK2 IFNAR2 [activation] MEOX2 NLGN3 [activation] EBI3 SMAD3 [activation] PTPRK MET [inhibition] E2F1 MAGEA11 [activation] INCA1 CTNNBIP1 [inhibition] MTOR TRAF2 [activation] ESD GRB2 [activation] AAR2 ARF6 [activation] RPA3 RFC4 [activation] MYC CPSF2 [activation] HIST2H3A BRD7 [activation] NCK1 FANCA [activation] BCCIP HIST1H2BN [activation] 页 87 共 454


AHDC1 ITSN2 HSPA8 FBXO6 FLNC ADRA1B CD40 HSPA4 PIK3CG ADRBK1 NDEL1 PXN CTSV RB1 SRC DAB1 SRC ALK EPB41L3 ABL1 RAB3GAP2 ERG DKC1 EGF CPM APBB1IP ZDHHC17 CDK16 YWHAG HSP90AB1 CCNA2 ANAPC11 SP1 MYOG DDX6 GRB2 FGFR2 ITGA5 ASIC3 MAGI1 FYN ERBB2 MC4R MC1R SRPK3 BRIX1 EP300 TWIST1 SFRP4 NRAS EIF2AK2 CHUK ITGB4 ENPP2 NFATC1 SPI1 HDAC1 RBL1 UCN3 CRHR2 RELA HSPA1L DFNB31 MYO15A APP FDX1L PRKAA2 STIM2 PRNP PPFIBP2 NDRG4 CMTM5 RPS6KA3 HTR2A ECSIT NFKB1 PCBP1 TRAF6 PSD RAB40C CDC16 CDC5L SHOC2 RAF1 YWHAB SRPK2 ADTRP VTN HUNK CFL1 MDK SRPK2 PUM1 CDKN1A MAPK14 GMFB FANCD2 TRAF6 H2AFY ATF2 TP53 CAPZB MDM2 UBE2E3 BANP RIMS3 CDC5L RAD50 TP53BP1 CDC16 DVL2 IRS2 SOX2 PRKCI GTF2A1 NFYA EIF3L HLA-C PPL CASP6 HSP90AB1 BMP6 ACVR2B ABR TP53 MAP2K2 MAPK8 MORC4 STAT3 ICAM3 APP KAT2B NR4A1 F7 CEP76 EIF3L GH1 SRGAP3 SMARCA4 ANAPC1 RPAP1 TOLLIP CSN2 ESR1 G3BP2 TUBB4A CHUK MAPKAPK2

2016/4/8 19:14

[activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] ARF6 [activation] [activation] [activation] [activation] [activation] ERBB4 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] AMHR2 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] ZFP36L1 [activation] 页 88 共 454


2016/4/8 19:14

CDK1 MARCKS [activation] STRAP FBXO6 [inhibition] HSPA8 IL32 [activation] NRAS MAPKAPK3 [activation] MAPKAPK3 EEF2K [activation] HCLS1 NOTCH1 [activation] RELA COMMD5 [activation] PTK6 FGFR1 [activation] ANKRD13B EGFR [activation] PPP1CC ENKD1 [inhibition] TIAF1 JAK3 [inhibition] STX4 RAB4A [activation] IQCK NCOA3 [activation] MAPKAPK3 SRC [activation] CDK1 FYN [activation] RAB7A HLA-B [activation] SRSF1 MDM2 [activation] TRAF6 PRPSAP1 [activation] SNW1 CDC23 [activation] NR3C1 PRKDC [activation] CDK11B URM1 [activation] BMPR1B RAN [activation] PAG1 VAV1 [activation] PTPN1 FAM84B [activation] TNFRSF17 TRAF3 [activation] CAPN1 TP53 [activation] RAP1B RAB7B [activation] CDH1 CDC27 [activation] TNFRSF14 HDAC3 [activation] STK4 H2AFX [activation] HSPA8 ERH [inhibition] ACTG1 VASP [activation] GEM BMP1 [activation] CSNK2B MGEA5 [activation] IL24 KRAS [activation] EIF3F EIF4G2 [activation] PRKCQ ICAM3 [activation] RAB9A BCL3 [activation] HIST1H2BN OBSL1 [activation;inhibition] CDC5L ANAPC2 [activation] NCOA1 BCL3 [activation] ATP4A GNAQ [activation] EP300 DYRK1B [activation] MYLK SVIL [inhibition] LOX COL1A1 [activation] EIF2B2 DCC [activation] TRAF1 CCHCR1 [activation] LAMB1 COL6A1 [activation] IL16 MYC [activation] VCAM1 PPIL1 [activation] PPP2CA FOXO3 [inhibition] CDC42 PLEKHG2 [activation] PIK3CD IL4 [activation] PIK3R1 ID4 [activation] ARF6 CS [activation] PVR CD226 [activation] SRSF10 SRSF4 [activation] NXF1 SCRIB [activation] SRPK1 DGCR8 [activation] RPA1 BRCA1 [activation] PTPRC MET [activation] CAV1 GRK1 [activation] VEPH1 SMAD1 [activation] RAB11B H2AFX [activation] SDC4 SDC2 [activation] CDKN1B CKS1B [inhibition] ST14 CHEK2 [activation] GPS2 DBNL [inhibition] HNF4A RAD50 [activation] IKBKB CDKN2A [activation;inhibition] PAK2 SYN1 [activation] HOXD9 BARX1 [activation] GSK3B LUC7L2 [activation;inhibition] CSNK2B ATF1 [activation] ELAVL1 B4GALT1 [activation] GEM AHCYL1 [activation] 页 89 共 454


2016/4/8 19:14

CD81 WARS [activation] PAXIP1 PPP1CC [activation] GRN SMAD9 [activation] EIF2S1 PRKRIR [activation] APAF1 YWHAE [activation] PDPK1 CDAN1 [activation] KLF10 SP1 [activation] ABL1 GAB3 [activation] RAB6B TGFBR1 [activation] SMAD4 SASH3 [activation] DYRK1A RBL1 [activation;inhibition] BARD1 LRRC41 [activation] ATP7A CP [activation] MYBL2 LIN9 [inhibition] GRN SORT1 [activation] GNAI2 NOTCH2NL [activation] PIK3R1 ARAF [activation] GNAI2 F2R [activation] GRB2 YWHAE [activation] HSP90AA1 CDK6 [activation] UBC MAPK14 [activation] PRKCE BAX [activation] GABARAPL1 F7 [activation] POLD1 ABL1 [activation] PRDX2 STK4 [activation] KITLG CLEC11A [activation] ATF2 HSPD1 [activation] TGM1 MDK [activation] IRAK4 HIST1H1B [activation] USF1 TOP2B [activation] UBA5 HSP90B1 [activation] HNF4A CTNNB1 [activation] NRAS ACVR1 [activation;inhibition] MDK STAT1 [activation] YWHAH TSC2 [activation;inhibition] CTNNB1 DDX1 [activation] IGHA1 UNC79 [activation] BIRC5 CASP3 [activation] NFE2L2 BPTF [activation] YWHAG PPP1R3D [activation] PPP3CA GABRG2 [activation] DAB2IP TNFRSF1A [activation] SOCS2 SOCS1 [inhibition] PRKRA SETDB1 [activation] PRRC2B EHMT2 [activation] MAPKAPK5 GYS1 [activation] PAFAH1B1 KATNB1 [activation] DNAJA1 PTP4A3 [inhibition] CAV1 MALL [activation] DVL3 CSNK1D [activation] LUC7L2 LPL [activation] PRR5 MLST8 [activation] YWHAZ ANXA1 [activation] HLA-B HSPE1 [activation] PRPSAP1 ASB18 [inhibition] PKLR PAK1 [activation] SNRPA1 HLA-B [activation] NME2P1 ATF2 [activation] PTEN PPP3CA [activation] POLR2B RECQL5 [activation] CDC27 RB1 [inhibition] DHX57 BARD1 [activation] PDGFRB CAV1 [activation] CDK7 CDK19 [activation] TGFB1 SCGB3A1 [activation] LGR4 RSPO2 [activation] FANCC EIF2AK2 [activation] BCL2L11 FGL1 [activation] PDGFRB ERRFI1 [activation] DBR1 EGFR [activation] PDCD10 MST4 [activation] PTPN1 ASS1 [activation] ATF2 LDHB [activation] CDC5L GNAS [activation] RSU1 ILK [activation] RAI1 RPS6KA5 [activation] 页 90 共 454


2016/4/8 19:14

MAP3K1 DNAJB2 [inhibition] GRB2 CSF3R [activation] GRK5 AKT2 [activation] ANAPC5 NOTCH1 [activation] ANXA7 CDK4 [activation] CDCA2 CDK1 [activation] PLCG1 ABI1 [activation] SUMO1 ARPC1B [activation] HOXD13 SMAD5 [activation] CALM1 PCK1 [activation] VDAC3 OBSL1 [inhibition] KCNB1 SRC [activation] MAP2K1 CFLAR [activation] CSNK1E AXIN2 [activation] CMTM3 BTK [activation] ILVBL ILK [activation] PIAS1 SMAD7 [inhibition] GNAI2 LPAR3 [activation] VCAM1 NUP155 [activation] HGS MAP3K7 [activation] AASDHPPT PAXIP1 [activation] PTPRC PPFIA1 [activation] UBE2Q2 ACTG1 [activation] EGFR SLC7A5 [activation] ZFYVE9 STX3 [activation] PRNP CNTN1 [activation] ATF2 PGAM1 [activation] EIF4E EIF4EBP1 [inhibition] VAV1 SHB [activation] PCDHA9 CRK [activation] ITGAV MMP2 [activation] PRKRA TP53 [activation] TRIP6 TLR2 [activation] SMARCC1 STAT2 [activation] MDM2 ERBB3 [activation] HNF4A PPARGC1A [activation] NFYC CSN2 [activation] PPFIA1 CDKN1A [activation;inhibition] DVL2 WAS [activation] GAPDH BID [activation] CDC5L KPNB1 [activation] ACVR1 KLHL35 [activation;inhibition] APBB1 HDAC1 [activation] EEF2 CDKN2A [activation;inhibition] CTNNB1 NXF1 [activation] F2 KNG1 [activation] CD2 SH3KBP1 [activation] REL HSPA1L [inhibition] NCF1 CTTN [activation] PML MAPK11 [activation] ICMT RAC2 [activation] CRK F2RL2 [activation] BMPR2 NOP56 [activation] SNAP25 HTT [activation] DLGAP3 PTK2 [activation] DDX39B SUMO3 [activation] ATG5 GXYLT1 [activation] EXOC5 EXOC3 [inhibition] YWHAZ KCNK15 [activation] CIAO1 RTEL1 [activation] ULK2 MAPK3 [activation] MAPRE1 SPDYE2 [activation] NCOA3 RELA [activation] AGAP2 INSR [activation] MAFK NFE2L2 [activation] SCYL3 TXN2 [inhibition] RHOA DGKQ [activation] E2F1 KAT5 [activation] SLFN5 NOTCH1 [activation] YWHAQ TP53 [activation] CRK AGPAT4 [activation] OPRD1 OPRM1 [activation] RAC1 IQGAP1 [activation] TGM4 IGHA1 [activation] CHEK2 LYPD3 [activation] COL1A2 VWF [activation] 页 91 共 454


2016/4/8 19:14

DOK1 FES [activation] CD81 CNN2 [activation] MYC KIAA0319 [activation] ARFGEF3 PTH [activation] APLP1 EIF2S2 [activation] CFTR PRKG1 [inhibition] ATF4 KAT2B [activation] PIK3R1 SOCS1 [activation] GRB2 HSPA5 [activation] GNAO1 S1PR5 [activation] RHOQ UBC [activation] FAM46A PSG3 [activation] CCDC120 CCDC102B [activation] RAB11B APP [activation] PPIG RHOB [activation] ZBTB17 ESR1 [activation] PTK2B SKAP2 [activation] SORBS1 EFNB1 [activation] LCK CD4 [activation] KMT2A CXXC1 [activation] ERBB2 PLXNB1 [activation] NFASC SDCBP2 [activation] MYC BTAF1 [activation] PACSIN3 APBB1IP [activation] GRAP2 ASAP1 [activation] TNFSF11 PHAX [activation] ECT2 TP53 [activation] EGFR SYN1 [activation] ACACA BRCA1 [activation;inhibition] DSG1 GABARAPL1 [activation] NLK PASK [inhibition] NFYC GLTSCR1L [activation] MTOR GNB1 [activation] GRB2 PTBP1 [activation] RPA3 NTPCR [activation] XPO7 NXF1 [activation] TRIM24 ESR1 [activation] TNF RAB5A [activation] RANBP2 PML [activation] YWHAH SNCA [activation] LILRB2 FCGR1A [activation] CAPN2 F2RL1 [activation] DAB1 LRP1 [activation] MAPK1 ITGB6 [activation] HSPA4 PRKCB [activation] WHSC1 SMARCA5 [activation] SYNGAP1 ULK1 [inhibition] WHSC1L1 CASP8 [activation] NCK2 ERBB2 [activation] TNS1 GAB1 [activation] YWHAZ SAV1 [activation] PML NR3C1 [activation] DAB2IP GSK3B [inhibition] EIF4A3 SUMO1 [activation] PICALM CASP8 [activation] ESR1 CXCL1 [activation] STRA13 FANCA [activation] BTRC TIAM1 [activation] NTHL1 RBL1 [activation] SLC25A13 GRB2 [activation] RAD21 SUMO1 [activation] CFLAR TICAM1 [inhibition] CSNK1G1 FAM219A [activation] PTPN11 CXCR4 [activation] IRS4 YWHAB [activation] GNAI3 VCAM1 [activation] EIF2AK3 HSP90AA1 [activation] CDK1 FANCC [activation] HOXD9 ETV5 [activation] TCF20 MAPK14 [activation] CTNNA1 PTPN14 [activation] YWHAZ HSPA1A [inhibition] BRCA2 CDK1 [activation] DOK1 ABL2 [activation] NFATC2 RIPK2 [activation] KSR1 MARK3 [activation] 页 92 共 454


2016/4/8 19:14

ANXA13 KIFC3 [activation] CBL SOS1 [activation] CDC25B CSNK2A1 [activation] SUMO3 EEA1 [activation] SPP1 UBQLN4 [activation] CEP170P1 ABI3 [activation] VEGFA HSPA4 [activation] PRLR NEK3 [inhibition] CCR5 CD4 [activation] SETD7 TBP [activation] APP PIK3R5 [activation] MAP1LC3A MIF [activation] RAD17 PRKDC [activation] DLG4 PTK2B [activation] ITGA2B FGA [activation] SRPK1 MRPS11 [activation] ESR1 JUNB [activation] CD36 COL1A1 [activation] ESR2 ACTN3 [activation] TP63 YAP1 [activation] CCND1 TSTD2 [inhibition] RAB2A PRKCI [activation] RHOB FNTA [activation] RARA FAS [inhibition] SRPK1 EIF4A3 [activation] TP53 CHD8 [activation] BCL6 WNK4 [activation] SIRT3 NCAPD2 [activation] IGHG3 IKBKG [activation] ITGB2 RDX [activation] TRAPPC8 PAXIP1 [activation] PTPRC PTPRCAP [activation] HIST1H2BC ICAM1 [activation] MEA1 MDM2 [activation] APP PLK2 [activation] RPS6KB1 CSNK2B [activation] CD247 GAB2 [activation] PDZD11 ATP7A [activation] HLA-B TKT [activation] EP300 SAV1 [activation] KRIT1 ITGB1BP1 [activation] DUSP10 HTT [inhibition] TMEM173 STAT6 [activation] APOA1 AKT2 [inhibition] CREBBP STAT6 [activation] NANS EGFR [activation] NLK TFDP1 [inhibition] MAPK6 PSIP1 [activation] MAP4K1 LRRK1 [activation] DNA2 NXF1 [activation] PLD2 SRC [activation] GREB1 PALB2 [activation] MDM2 GSN [activation] TCEB3B CDK6 [inhibition] MDM2 HNRNPAB [activation] NCCRP1 ESR1 [activation] HSP90AA1 PRKCQ [activation] BRD7 HIST1H2AA [activation] SPINT1 FAM46A [inhibition] SUMO1 GNAS [activation] CREBBP MKNK1 [activation] IGF1R GNAI1 [activation] RPTOR AMBRA1 [activation] IKBKB PPARG [activation] CDK6 CBY1 [inhibition] PELI1 SRPK1 [activation] GRB7 RND1 [activation] ATOX1 FAM118A [activation] PPP2R4 NXF1 [activation] PTGER4 ARRB1 [activation] GAB1 TNS3 [activation] BTK PIP5K1A [activation] MAP4K1 HCLS1 [activation] SHC1 TEC [activation] RHPN2 HLA-C [activation] CDKN1A NKD2 [inhibition] 页 93 共 454


2016/4/8 19:14

DAG1 VCL [activation] PARVB CDC5L [activation] GRB2 ITGB4 [activation] USP7 TRAF3 [activation] TRAF2 TNFSF9 [activation] PPP6C ESR2 [activation] DLG5 TGFBR1 [activation] HIST2H2BE GZMA [activation] DMC1 RAD51AP1 [activation] UBC NSD1 [activation] CDC23 PNMA5 [activation] CASP9 NOD1 [activation] PAXIP1 NOS3 [activation] HNRNPA1 ARHGAP23 [activation] ARRB1 PFKFB3 [activation] PRKCD MAPT [activation] CLTA TP53 [activation] GRB2 TSKS [activation] TP53 GSN [activation] TJP1 GJB3 [activation] EP300 TGFB1I1 [activation] GKN2 TFF1 [activation] PBX3 AGTRAP [activation] NRIP1 ARPC3 [activation] SH2D3C KIT [activation] SRC PDPK1 [activation] S1PR4 GNAI1 [activation] ESR2 GNB3 [activation] NR3C1 PRKACA [activation] ARF1 GOSR2 [activation] NR3C1 SRSF5 [activation] ID1 GATA4 [activation] SHC1 SUV39H2 [activation] HSP90AB1 TNK1 [activation] DACH1 SMAD4 [inhibition] GABRG3 GABARAP [activation] GNPAT HSPB1 [activation] CUL3 PPP2CA [inhibition] H2AFX PRDX3 [activation] HSPA6 TRAF3IP1 [activation] GAPDH CAMK4 [inhibition] RAD21 BRCA2 [activation] PRKCZ GABARAP [activation] TOLLIP IRAK2 [activation] ARPC2 GRB2 [activation] PRPF38A SRPK2 [activation] LAMC2 BMP1 [activation] CEP170B PRKAA2 [inhibition] GDAP1 NXF1 [activation] BIRC2 TNFRSF12A [activation] LIG1 CSNK2A1 [activation] PRKAB1 CYCS [inhibition] MAP3K12 EGFR [activation] RHOBTB2 CHEK2 [activation] EXOC6 APP [activation] NUMB BMP2K [activation] ABL2 ABI1 [activation] BMPR1A CTSV [activation;inhibition] CAV1 MAPK1 [activation] CCDC50 RIPK1 [activation] CDK1 MDM4 [activation;inhibition] TTLL4 NXF1 [activation] CIB1 PAK1 [activation] SMAD2 ESR2 [activation] TREM1 TYROBP [activation] CDC5L PUM1 [activation] PPP2CA SCHIP1 [inhibition] GOSR2 STX5 [activation] SPATA2 GNAL [activation] EFNA3 MEOX2 [activation] HCK DOK2 [activation] CD19 GRB2 [activation] ICT1 NGRN [activation] KRAS OSGIN1 [activation] CSF1 PIK3R2 [activation] CD4 KCNAB2 [activation] 页 94 共 454


HSPH1 MAP3K1 PAFAH1B3 EP300 SIRT1 CSMD2 ABL1 SOX2 CASP8 SAV1 YWHAH NFYC KAT2B NOD2 TRAF6 VCAN CCL5 CDH15 CDH9 SRPK1 METTL14 TEAD1 MEF2A RPL31 TP53 TIAL1 RPA2 RIPK2 TRAF6 ANGPTL4 CASP8 GRB2 CDC42 PRMT7 H3F3C MAPK13 PFN1 KAT2B HSD11B2 MUC7 LAMA5 PTK2B MAP3K4 GNB2L1 STAT1 CBR1 GRB2 PIK3CA PSMC3IP CALM1 RDX YWHAZ EIF4E2 MAP4K2 RAB8A CD81 JAK3 LGALS4 ARPC3 CAMK1 APP CAPN1 VIM BIRC2 RAC1 PSD2 PMS1 SP1 PER3 TRAF6 TRAF2 PPP3CC CABIN1 PTK2 SOCS2 BUB3 ITGA4 PI4KA MTNR1B NLGN1 NRXN2 PON2 HTR2A FCN1 TGFB1 HSPA2 FKBPL SYK TICAM1 RPL35A GRB2 POLA2 RAE1 P2RX2 GABRR1 SMAD2 FBP2 CTNNB1 DOT1L FOXO3 CREBBP NSD1 NR6A1 HSPB1 NVL C9orf156 F8 F2 CAV1 RPA2 JAK2 PPP2R4 TLN1 EGFR ABL1 F2RL2 CAV1 NOS3 POU5F1 NCL SFN FAM53C ARRB2 STC2 RAC3 NRBP1 RPA3 EPRS ACVRL1 INHBA RADIL RAD51D LYN DVL2 XPO7 NUP153 RXRA BHLHE41 RAD21 RPS17 GSK3B PRKACA MYO9A NXF1 TNFSF14 LTB L1CAM NCAM1 HNF4G SRC

2016/4/8 19:14

[activation] VCAM1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] TGFBR2 [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] 页 95 共 454


2016/4/8 19:14

NGFR TRAF3 [activation] GLUL HLA-B [activation] ERBB4 SYK [activation] PTK2B MCAM [activation] NXF1 HSP90AA1 [activation] CDC42BPB TJP1 [activation] AR BLK [activation] MAPK14 BAZ1B [activation] GADD45G PTN [activation] NR2F1 ISL1 [activation] HSP90AB1 BRAF [activation] CTR9 RTF1 [activation] BCL2A1 BCL2L11 [activation] DKC1 EPB41L3 [activation] PRKCZ PARD6G [activation] FOXJ1 SLC37A3 [inhibition] H2AFX TP53 [activation] CNOT1 GRB2 [activation] NFATC2 HNRNPA1 [activation] DNAJA2 DNAJA4 [inhibition] DPYSL2 TNIK [activation] YWHAE TIAM1 [activation] SLIT2 ETS1 [activation] GRB2 FSCN1 [activation] HSD17B3 BRAF [activation] POLK RPA1 [activation] ABI2 SH3KBP1 [activation] SERPINE1 UBQLN4 [inhibition] NCK2 SRPK1 [activation] PRKCA SHC1 [activation] RAD51 TP53 [activation] EGFR APP [activation] EP300 IL8 [activation] SNCA CSNK1D [activation] ARRB1 BTK [activation] MAPK1 CRP [activation] LRRIQ3 LYN [activation] CASC3 GRB2 [activation] ANAPC10 CDC20 [inhibition] LARS RRAGD [activation] CR1 CD55 [inhibition] CD40 RIPK2 [activation] KCNA4 NEU1 [activation] PTP4A3 MYO1B [activation] MAP3K1 CRTC1 [activation] ADORA2A NAMPT [activation] CASP8 SRF [activation] ADCY5 RGS2 [activation] CDK3 CCNE1 [activation] SIGIRR IRAK1 [activation;inhibition] SP1 E2F2 [activation] CDC42SE1 CDC42 [activation] PPP1R15A HSPA1A [inhibition] TRAP1 RAD21 [activation] CISH KIT [inhibition] CDK19 MED1 [activation] NUP62 CCDC153 [activation] DAAM1 RHOD [activation] ITGAM ELANE [activation] MYC KIF25 [activation] FAS C14orf1 [inhibition] ABL2 SRC [activation] WEE1 ARRB2 [inhibition] BNIPL CDC42 [activation] RAB10 EPB41 [activation] NBN PAXIP1 [activation] EPAS1 PIAS2 [inhibition] GH1 CALM1 [activation] MT1A GPR50 [activation] L1CAM ITGA5 [activation] GSTP1 MAPK14 [activation] TNF HSPB1 [activation] GAB3 PTPN11 [activation] SFN KIF23 [activation] CD36 SRC [activation] DNAJA3 STAT1 [inhibition] 页 96 共 454


2016/4/8 19:14

MYC HDAC1 [activation] ZC3H12A EP300 [activation] MCM3 HIF1A [activation] BTRC CCNB1 [inhibition] PLAUR ITGB1 [activation] CHMP2A ITGA4 [activation] TRIM41 SRPK2 [activation] IL13RA2 IGF1R [activation] WWTR1 HIF1A [activation] TNFRSF14 NCLN [activation] CHEK2 PPP2CA [activation] PIK3R3 GRB2 [activation] MYB LIN9 [activation] LRRK2 NOMO2 [activation] ORAI3 ORAI1 [activation] CCND3 RBL2 [inhibition] STK16 NOTCH2NL [activation] GRIP1 NCOA1 [activation] EGFR CDC37 [activation] RAD51B HIST1H4A [activation] TNF SHARPIN [activation] YWHAB TANC2 [activation] NR3C1 PRPF6 [activation] ELK1 HDAC1 [activation] BMP8B FYN [activation] PDGFRB CRK [activation] CAMK2G PLCB3 [activation] PRKCG NFE2L2 [activation] ANXA9 APP [activation] ACVR2B BMP2 [activation] ESR1 CAPZB [activation] EEF2K RPS6KB2 [activation] CYTH2 GNAQ [activation] MYC HSPH1 [activation] MLLT4 GRB2 [activation] RFC1 RAD50 [activation] ILK S100A9 [activation] BCAR1 NEDD9 [activation] DNM2 APPL1 [activation] RAB11FIP1 YWHAB [activation] TP53 UBE2K [activation] PAX8 WBP2 [activation] CXCL5 MMP9 [activation] HIST2H2BE GADD45A [activation;inhibition] AGR2 MLH1 [activation] FCGR3A CD38 [activation] LEF1 PIAS4 [inhibition] PLCB1 TRPC3 [activation] TNFRSF1A ACTG1 [activation] CAPN1 CLEC4G [activation] ATM ZNF821 [activation] GRB2 CALD1 [activation] SMAD2 SEMA6A [activation] SH3KBP1 DAB1 [activation] NOTCH2NL CCDC26 [activation] CD48 GNAI3 [activation] SRC PPARA [activation] EIF4A1 SUMO1 [activation] FN1 ACACA [activation;inhibition] PYHIN1 MDM2 [activation] BMPR1B IGSF1 [activation] SH2B2 INSR [activation] RB1 NDC80 [inhibition] TNFRSF14 VIM [activation] MADCAM1 ITGA4 [activation] SP100 NXF1 [activation] RADIL CDK2 [activation] CDK5R1 CHN1 [activation] YWHAZ GP5 [activation] AXIN2 AXIN1 [activation] MAP2K1 BRAP [activation] RXRA RNF8 [inhibition] LAT CREB3 [activation] ERBB2 SH2D5 [activation;inhibition] KIT SH3BP2 [activation] GRB2 INCA1 [activation] 页 97 共 454


2016/4/8 19:14

LRRK2 DAPK1 [activation] IGHG1 SWAP70 [activation] DYRK1A SMAD3 [activation] ITGB1 NME1 [activation] SUV39H1 LENG8 [activation] AR CCNH [activation] CDK2 BCL2 [inhibition] IL12A IL8 [activation] IGHG1 RTKN2 [activation] KNG1 GP1BA [activation] KCNK5 FRAT1 [activation] TP53 BAIAP2L1 [activation] TCL1A JUN [activation] MAPKAPK5 EIF4EBP1 [activation] NOS1 PTPRN [activation] RAN IKBKB [activation] ICT1 DHX30 [activation] PTEN XIAP [activation] TULP4 SRC [activation] LCK AJUBA [inhibition] TEC PIK3R3 [activation] LARS VCAM1 [activation] MLH1 CUTA [activation] RXRG PPARA [activation] ESR1 PTEN [activation] RPL14 PCK1 [activation] SERPINE2 COL4A3 [inhibition] CXCL9 SYNE4 [activation] SRPRB TNFRSF14 [activation] ENO1 HSPA8 [inhibition] SYT4 STX3 [activation] NCL FOS [activation] MYBL2 CCNE1 [inhibition] DFFA HSPB1 [activation] ERBB2IP CTSG [inhibition] FOS CABP1 [activation] ECE1 KNG1 [activation] GRB2 REPS1 [activation] CDK11A EIF3F [activation] PRKAR1A PYCARD [inhibition] GCK PFKFB1 [activation] GRIP1 PPARG [activation] PRKAB2 MAP3K6 [inhibition] CRK CBL [activation] EGFR CAMK2G [activation] RASGRF1 RRAS2 [activation] MRE11A MDC1 [activation] MME ADCYAP1 [activation] KIF23 RACGAP1 [activation] HIST1H1A IRAK4 [activation] ENPP2 LPAR1 [activation] SMARCC1 GRB2 [activation] PRKAB2 GATA1 [activation] SUFU GLI2 [activation] MYD88 SASH1 [activation;inhibition] ERBB3 PTK2B [activation] PRKCZ YWHAZ [activation] YWHAE NGFRAP1 [activation] STX5 ASNA1 [activation] FYN TGOLN2 [activation] MDC1 FANCD2 [activation] SFN ARHGEF16 [activation] CDC16 EP300 [activation] CCDC33 PTK6 [activation] PRDX3 MDM2 [activation] GRK5 ARF1 [activation] COA7 MDC1 [activation] CDKN1A TMSB4X [activation] RALA PPP2R1B [activation] MVP GIT2 [activation] TYK2 CRKL [activation] HSP90AB1 NPR2 [activation] CTR9 HIST1H3A [activation] DNAJA1 OBSL1 [inhibition] WAS BTK [activation] RCC1 RAN [activation] 页 98 共 454


2016/4/8 19:14

STK11 EEF1A2 [activation] ARRB2 GPR56 [activation] MYC PKM [activation] SRPK1 FLT1 [activation] STX3 SYT7 [activation] VSNL1 CHRNA4 [activation] TFRC ACAP1 [activation] LPA APOH [activation] SFN CCNH [activation] DDA1 EIF5 [activation] DOCK8 FAM124A [activation] YWHAB STK3 [activation] CDK6 PPM1B [inhibition] KLF5 CREBBP [activation] SIRT1 NHLH2 [activation] MAPKBP1 MAPK8 [activation] FBXO6 PRF1 [activation] PRKCB ANXA2 [activation] ITGA4 CAPN1 [activation] KIR2DL4 FCER1G [activation] MET SOCS3 [activation;inhibition] GABARAPL2 GOSR1 [activation] BRPF3 PIK3R1 [activation] CREBBP MYBL2 [activation] EIF4G1 MDM2 [activation] RALA RALGPS1 [activation] LRP6 MESDC2 [inhibition] DLG5 CTNNB1 [activation] ACKR2 CCL5 [activation] ARL8B DLEU1 [activation] EZH1 GATA4 [activation] OPRK1 VAPA [activation] SRPK2 VAV2 [activation] CDH1 STX17 [activation] ZAP70 PLCG1 [activation] ERBB2 PIK3C2A [activation] EIF4G2 VCAM1 [activation] STAG2 SGOL1 [activation] ERCC4 SLX4IP [activation] GRB2 PIK3C2B [activation] CLDN4 WNK4 [activation] RPS6KA1 HSP90AB1 [activation] MCM7 LYN [activation] KLF5 PRKCA [activation] IQGAP1 CDC5L [activation] CAMK2A LRRC7 [activation] VPS35 VEGFA [activation] PDPK1 YWHAH [activation] DOK5 EGFR [activation] CDH2 PTPRJ [activation] CEACAM1 PTPN11 [activation] ABL1 ERBB4 [activation] SRPK1 LUC7L [activation] RAN NR4A2 [activation] KMT2D ESR1 [activation] AKAP8 CCND1 [activation] CRK DNM2 [activation] GUCY1A3 MAPK8 [activation] EPB41L3 CADM1 [activation] GAP43 PRKCB [activation] TGFB1 MTA3 [activation] STX7 SNAP29 [activation] DUSP3 MAP2K2 [activation] MBP MAP3K5 [inhibition] SMAD3 FLI1 [inhibition] FAM208B SCAMP1 [activation] SPRY1 LCE1B [inhibition] ATM CHD4 [activation] SRPK2 ZMAT4 [activation] OGT MAPT [activation] MAPK13 PGK1 [activation] PRKCH PRKD1 [activation] BCL6 MTA3 [activation] RGS13 GNAQ [activation] IQGAP1 LRP6 [activation] TRAF2 GSK3B [activation] 页 99 共 454


2016/4/8 19:14

U2AF2 GH1 [activation] DYRK1A CLASRP [activation] ITK GAB1 [activation] ORMDL1 APP [activation] ERBB2 NUDCD3 [activation;inhibition] PTAFR JAK2 [activation] UMPS PIK3CA [activation] AMER1 APC [inhibition] GSTK1 EIF2B5 [activation] YWHAB SHKBP1 [activation] CDC20 EP300 [activation] MSL2 WNK1 [activation] VAPA EGFR [activation] DMPK PLN [inhibition] HNRNPA1 ARRB2 [activation] MYB SPTAN1 [activation] EGFR TPT1 [activation] HEMGN EGFR [activation] ILK TRABD [activation] TIAL1 MAPK1 [activation] CAPZB GRB2 [activation] MRE11A AIM2 [activation] PPM1E ARHGEF7 [activation] UBC ATG7 [activation] ACTB MAPT [activation] HSPB1 SIK2 [activation] C11orf87 SRPK1 [activation] APP CST2 [inhibition] MYC AIFM2 [activation] SH2D2A SMAD2 [inhibition] FGF16 APP [activation] VAPA GABARAPL2 [activation] CASP1 ATG16L1 [activation] EXOC1 RALA [activation] PAK6 AR [activation] HSPB1 EGFR [activation] CUTA GRB2 [activation] BICD1 MAPK14 [activation] CTBP1 HIST3H3 [activation] TYRO3 PROS1 [inhibition] RELA IRF1 [activation] A2M ENO2 [inhibition] GABARAPL2 SEC23B [activation] NOTCH1 LEF1 [activation] HSPB1 NFKBIA [activation] RAB20 NXF1 [activation] QIL1 TNFRSF14 [activation] PLCG1 PLXNB1 [activation] HLA-A PRKCA [activation] SMARCA4 PPARG [activation] TRAF6 RAB10 [activation] ADRA1B DRD4 [activation] EIF4G2 PTP4A3 [activation] JAKMIP2 CLIP4 [activation] CENPA FYN [activation;inhibition] NUP43 HLA-B [activation] UTP3 DVL3 [activation] IRAK3 TRAF6 [inhibition] ANXA5 ATF2 [activation] RAD51D LZTS2 [activation] FYN ARHGAP32 [activation] CORO1C LRCH3 [activation;inhibition] GNAQ ADRBK1 [activation] CDKN1A CDC5L [activation] ARRB2 H2AFX [activation] MED1 AR [activation] ANG TNFSF8 [activation] NCF1 AKT1 [activation] MCM7 EPAS1 [activation] GRB2 CYFIP2 [activation] PTPRD PTPRF [activation;inhibition] PLK1 MAPK6 [activation;inhibition] SYK DBNL [activation] HSPA6 GABARAPL2 [activation] GDF9 CDKN2C [activation] INS SYTL4 [activation] 页 100 共 454


2016/4/8 19:14

ACTN1 GRB2 [activation] TAGLN2 OBSL1 [activation;inhibition] IVL LOR [activation] HNRNPA1 HSP90AB1 [activation] TP53 EIF5B [activation] APP PSRC1 [activation] PARP11 NUP98 [activation] YWHAE TBK1 [activation] OSGIN1 DNAJA3 [inhibition] AURKA MAPRE3 [activation] USP10 TP53 [activation] AURKB SHARPIN [activation] BMI1 TP53 [activation] VCAM1 HEATR1 [activation] GPRASP1 CHRM2 [activation] AKAP1 DYSF [activation] SRRM1 SRPK3 [activation] LAMTOR5 MYOG [activation] RASA1 SERPINA4 [inhibition] HSP90AB1 DDR2 [activation] PRKAA1 SUPT16H [inhibition] HMGN3 SRPK2 [activation] ERBB2 GNB3 [activation] CCL14 ACKR2 [activation] HDAC4 PPP2CA [inhibition] FES JAK2 [activation] ECT2 CD19 [activation] PAK2 MYL2 [activation] CCNB1 CDC6 [activation] HMGB1 DNM2 [activation] DNAJC28 PYCARD [inhibition] HCK TNK2 [activation] RELA USF2 [activation] IGSF8 HIST3H3 [activation] NR3C1 STAT5A [activation] CD1D PTPRC [activation] LRRK2 DAPP1 [activation] PYCARD IKBKB [inhibition] HSPB1 IKBKB [activation] CDKN2A MYL12A [activation;inhibition] EGFR UFL1 [activation] GRB2 DHX9 [activation] LAMTOR5 RRAGA [activation] CSN3 CSN2 [activation] MYL1 VCAM1 [activation] AGTR2 GNAI2 [activation] MYC ARF4 [activation] RASA1 RB1 [activation] BARD1 EXOC5 [activation] PPARA HSP90AA1 [activation] EGFR EFNB1 [activation] SOS1 ABI3 [activation] SRPK1 DHX8 [activation] HSPB1 ASB4 [inhibition] CCDC37 SUV39H1 [activation] CDKN2A HSPA4 [inhibition] BCCIP EGFR [activation] EPB41L3 ARRB2 [activation] PRKCD HIST1H1A [activation] FADD PRKCZ [activation] ICAM1 HIST1H1A [activation] SKAP1 FYB [activation] HCK SKAP2 [activation] IGF1R MTA3 [activation] NUDCD3 KLHL1 [activation] PAK1 MBP [activation] AURKB STK3 [activation] HIST1H4A ESR2 [activation] EP300 IRF7 [activation] TSC22D1 A2M [inhibition] TSR1 BMPR2 [activation] RAG1 CRK [activation] ACTB CNN2 [activation] ICK CDK20 [activation] PBK NXF1 [activation] SGK1 CD40 [activation] 页 101 共 454


2016/4/8 19:14

UVRAG PTPRA [activation] CYP11A1 SMAD2 [activation] VARS2 PIK3CA [activation] ACVR1B ACVR2A [activation] EIF4A3 HIST1H4A [activation] NUP153 EGFR [activation] NTRK1 FRS3 [activation] HLA-B PFN2 [activation] PLK1 MCM3 [activation] ERBB3 AGTR2 [activation] LRRK2 IGKC [activation] HUNK PPP2R1A [inhibition] GRN RPS6KA1 [activation] APP LATS1 [inhibition] PLXNB1 MRAS [activation] AURKB NEDD8 [activation] NME1 TERF1 [activation] DAXX TGFB2 [activation] KAT2B HIPK2 [activation] TRAF6 KPNB1 [activation] CHUK TRPC4AP [activation] ERBB2IP APC [inhibition] TXNDC5 GMPPB [activation] ESR2 CXorf22 [activation] MLH1 TPRG1L [activation] SMAD3 CITED2 [activation] LZTS2 CDK18 [activation] CSNK1E DVL1 [activation] SDF4 MOK [activation] PKM ITGA4 [activation] KDR TIMP3 [activation] C3 GC [activation] NUP214 XPO5 [activation] CSNK1A1L JAM2 [activation] NOXO1 CYBA [activation] PDGFA COL3A1 [activation] INHA ACVR2A [activation] FZR1 PTTG1 [inhibition] G3BP2 NFKB1 [activation] HDX YWHAE [activation] KCNA2 CNTNAP2 [activation] RHOQ DOCK8 [activation] ARHGEF7 PAK2 [activation] CFL1 CAP1 [activation;inhibition] CSF2RB KDR [activation] GIT2 PAK1 [activation] EFNA1 ADAM10 [activation] MYO1A SMARCA5 [inhibition] SEMA6D PLXNA1 [activation] CDK1 PTPN1 [activation] PIK3R1 PPM1A [activation] SMAD1 INPP4A [activation] PRNP NHP2 [activation] NR3C1 KMT2A [activation] CRKL YY1 [activation] RAP1A SMARCA4 [activation] STAT3 FGFR4 [activation] PRKCB KIT [activation] DLX5 SOX8 [activation] PTPN6 KDR [activation] GAPDH MAPK1 [inhibition] CREM CD34 [activation] ATP4A APOH [activation] FAM102A ENKD1 [activation;inhibition] PRKCB HIST1H1B [activation] NCK2 ABI3 [activation] EHMT2 ENKD1 [activation] APP SMAD3 [activation] CXCR2 ARRB1 [activation] ARPC4 ARPC3 [activation] ANK1 HSPB1 [activation] BCL2 MAPK3 [activation;inhibition] SOCS1 TEK [inhibition] WASF2 GRB2 [activation] LCK WASL [activation] SMAD7 AKT1 [activation] 页 102 共 454


2016/4/8 19:14

ALK PXN [activation] HSF1 HDAC2 [activation] ACVR1B INHBA [activation] DDX54 NR3C1 [activation] RIT1 SRPK2 [activation] PARD6A RAC1 [activation] CDK5RAP3 HSPB1 [activation] LRRK1 SOS2 [activation] RCVRN SMAD3 [inhibition] LRRK2 HMGN2 [activation] NXF1 CENPJ [activation] NOTCH1 IKZF3 [activation] SRPK1 LIMK1 [activation] RBL1 MCM7 [activation] CDK18 CCDC102B [activation] YWHAG EPB41L3 [activation] OBSL1 HIST1H2AA [activation;inhibition] FES PTGES3 [activation] ATF2 PRDX5 [activation] BUB1 STX17 [activation] YWHAH MAST2 [activation] RBL1 SP1 [activation] SMAD4 SERPINA1 [inhibition] HSPB1 C11orf48 [activation] CEP55 TP53 [activation] MDC1 RPA3 [activation] RPTOR IQGAP1 [activation;inhibition] PSEN2 MAST1 [activation] CDC25B KAT2B [activation] MAPK1 SNCA [activation] LCP2 EGFR [activation] FYB BCL10 [activation] PIM2 FBXO18 [inhibition] FOS SUMO1 [activation] RELA TGM2 [activation] NR3C1 TXN [activation] RND1 CREB3L2 [activation] ARAF DNAJA1 [inhibition] ARRB2 RPL7L1 [inhibition] CDH2 CDH4 [activation] DDX39B SNW1 [activation] MAVS OAS3 [activation] MEP1A CCK [activation] APP TNFSF14 [activation] NRIP1 ESR2 [activation] SEL1L UNC93B1 [activation] IL10RB UCN3 [activation] CDC5L PAXIP1 [activation] PLN DVL3 [inhibition] FYN GABBR1 [activation] FGF2 GPC3 [activation] HSPA2 SIRT6 [activation] PFKFB4 CSNK2B [activation] NMB BIRC2 [activation;inhibition] HABP4 PRKCZ [activation] ITGB1 FABP3 [activation] ICT1 MRPL41 [activation] CABLES2 TP53 [activation] NOS1 HSP90AA1 [activation] RAC1 PAK2 [activation] TBC1D4 YWHAB [activation] HSPA1L SIRT3 [activation] TGFB1 DIRAS3 [activation] TGFBR2 TRAP1 [activation] PLSCR1 CRKL [activation] FAM21C CCDC93 [activation] IRS1 PLCG2 [activation] EDA MAL [activation] LRRK2 RGS1 [activation;inhibition] HNRNPUL1 TP53 [activation] CASP1 TIRAP [activation] ARRB1 STK38 [activation] MAST1 APOE [activation] CEBPA SMAD3 [inhibition] NUP62 IPO5 [activation] SRSF5 ESR1 [activation] 页 103 共 454


2016/4/8 19:14

OGT GSK3B [activation] KCNQ1 HSPA4 [activation] SCAMP5 CREB3 [activation] HLA-B MARS [activation] SMAD7 ITCH [activation] TRAF1 DIABLO [activation] SOX1 STAT3 [activation] CDK5R1 STXBP1 [activation] STX7 NSF [activation] PLG C7 [inhibition] MYL1 LRRK2 [activation] EP300 BRD7 [activation] MAP3K8 BMPR2 [activation] ARHGAP27 CDC42 [activation] TXN2 MLH1 [activation] HSD17B4 GSK3B [activation] ILK SCO2 [activation] NGFR CAV1 [activation] CCDC155 GABARAPL2 [activation] EIF1B DDT [inhibition] SMC2 NCAPD2 [activation] SOCS3 NFKBIA [activation;inhibition] GNB2 MAP3K3 [activation] TRADD LRRK2 [activation] GADD45GIP1 ICT1 [activation] VCAM1 PTGES3 [activation] SMAD4 RRAS2 [activation] CTTN ACTG1 [activation] TANC1 CAMK2A [activation] DRD2 SSTR5 [activation] IKBKB JUN [activation] SRPK2 UBE2E2 [activation] RAD21 CP [activation] CD81 RTF1 [activation] BRAF MRAS [activation] CSK UBASH3B [activation] RBPJ SMARCA4 [activation] CBLB KIT [inhibition] CENPB ETS1 [activation] ERBB4 CTGF [activation] CIITA XPO1 [activation] ITGAV ITGB6 [activation] RPRD1B RPA3 [activation] RASSF2 HRAS [activation] PRKRA KIAA1377 [activation] PTK2 HSP90AA1 [activation] KRTAP5-9 P2RX4 [activation] RANBP2 NUP62 [activation] APP FOS [activation] RAF1 ARRB2 [activation] SIRT1 KCNA5 [activation] PPP2CA MID1 [inhibition] TP53 OLA1 [activation] GNAS RIC8A [activation] IRS1 SHC1 [activation] MAST4 SMAD1 [activation] PTPRF PPFIA3 [inhibition] BMP1 YLPM1 [activation] PRKCI GABARAPL1 [activation] CACNA1D BRK1 [activation] PTCH1 YAP1 [activation] GNAI2 GPSM3 [activation;inhibition] RALA REPS1 [activation] ARHGEF16 YWHAG [activation] WNK4 CLDN3 [activation] RAD21 TFG [activation] CREBBP ONECUT1 [activation] CTR9 NXF1 [activation] PHGDH STK4 [activation] SRC FYN [activation] STAT3 MOV10 [activation] PROC F8 [activation] DUS1L SRPK1 [activation] KMT2A OXT [activation] PIK3R1 NCK1 [activation] CD81 HIST1H2BK [activation] 页 104 共 454


2016/4/8 19:14

COL5A1 PDGFB [activation] TES SOCS3 [inhibition] ARFGAP3 CD14 [activation] ITGB2 ICAM5 [activation] BAAT SMAD4 [activation] CRK DOK1 [activation] PGK1 RAD21 [activation] CDK5R1 CDK6 [activation] BACH2 BCL6 [activation] MORN4 NYAP2 [inhibition] SRSF5 CD101 [activation] DNM1 CAV1 [activation] ZNF622 FOS [activation] PGAM5 YWHAG [activation] LRRK2 TMOD3 [activation] TNK2 EP300 [activation] LATS1 TJP2 [inhibition] GABRB3 ARFGEF2 [activation] PIAS2 PGR [activation] VAV3 PDGFRB [activation] SMAD4 JUN [activation] ATF2 AHSG [activation] FCAR PPP2CA [activation] ELANE NOTCH2NL [activation] JUN PIN1 [activation] RPA3 WDR3 [activation] IL2RB SHB [inhibition] HSPA4 ABL1 [activation] SETDB1 SUV39H1 [activation] EIF4EBP1 LRRK2 [activation] ABL1 LTBP2 [activation] PARD6A PRKCH [activation] PLCG1 ALK [activation] CCL22 VCAM1 [activation] NOTCH2NL GEM [activation] VAV1 SH3BP2 [activation] YES1 CDCP1 [activation] MAPK1 TP53BP1 [activation] GMFB GRB2 [activation] CALM1 CAMKMT [activation] SRC THRB [activation] MARK3 SAAL1 [activation] LRRK2 EIF3J [activation] UBE2Q2 MYO1C [activation] KPNA1 YWHAZ [activation] ACACA NXF1 [activation;inhibition] WIPF1 LRRK2 [activation] DNM1 PIK3R1 [activation] HSPA9 NFKBIA [activation] CDH2 GRIN2D [activation] SETDB1 AKT1 [activation] RASA1 ERBB3 [activation] LPA ELANE [activation] GNGT1 GNB3 [activation] SCAND1 MAPK8 [activation] DAG1 PTK2 [activation] APP DHRSX [activation] HMGXB4 HIST3H3 [activation] DDX5 SGK2 [activation] EIF2AK4 SMAD4 [activation] C1orf109 STX11 [activation] FURIN LRP1 [activation] SMAD2 CTNNB1 [activation] WNK1 FHOD1 [activation] TRAF3 BRAF [activation] BMPR1B SOCS6 [inhibition] PRNP CIRH1A [activation] YWHAB TPD52L1 [activation] ISL1 ISL2 [activation] VIM CASP8 [inhibition] PARD3 YWHAE [activation] POLR2A KMT2D [activation] STK4 PRKRIR [activation] GABARAPL2 HIST1H2AB [activation] KHDRBS2 GRB2 [activation] FYN CD48 [activation] 页 105 共 454


2016/4/8 19:14

EGFR IQGAP3 [activation] PTMS MYB [activation] HSPB1 LUZP1 [inhibition] PTH1R YWHAH [activation] OR1E2 RAD21 [activation] CRCT1 AGTRAP [activation] DYSF TAF1 [activation] GRK6 CHRM3 [activation] MAPK3 PRKCZ [activation] SP1 CASP3 [activation] CCDC67 EXOC5 [inhibition] PGR PIAS1 [activation] MYB PAX5 [activation] YWHAE C11orf84 [activation] RPTOR EIF4E [inhibition] CIAO1 ACACA [activation;inhibition] UBE2I CDK1 [activation] SRPK1 GRK5 [activation] SRPK2 MMTAG2 [activation] NUTF2 NXF1 [activation] FANCA PLCG1 [activation] PML PLCG1 [activation] PARD6A CDH5 [activation] PTTG1 ANAPC11 [inhibition] PARD3 LIMK2 [activation] PXN NCK1 [activation] ESR1 TAF1B [activation] DDX5 ARF6 [activation] SMAD2 ETV4 [activation] PRKACB AKAP7 [activation] SERPINA5 FGG [inhibition] TRADD TRAF3 [activation] BAD PRKCE [activation;inhibition] PYHIN1 AGRN [activation] LUC7L2 GABARAPL2 [activation] RRAS2 RIN1 [activation] GIP ADAMTSL4 [activation] CUL1 SKP2 [inhibition] FADD ABCA1 [activation] EPAS1 SP1 [activation] STK4 HSPA8 [activation] RAB5C ARRB2 [activation] VCAM1 DDX5 [activation] CXCR4 VAV1 [activation] CRK PCDHA2 [activation] LRRK2 PYCR1 [activation] MRPL51 ICT1 [activation] FCGR2B SRC [activation] CD79A IGHM [activation] ARRB2 EIF4B [activation] IQSEC1 MCM7 [activation] GNA13 CDH2 [activation] TRAF2 RIPK1 [activation] CAMK1 ATF1 [activation] SMAD2 SLC25A6 [activation] GRB2 ACTL6A [activation] MAP2K5 STAMBP [activation] SORT1 LRPAP1 [activation] ITSN2 CBL [activation] RIPK1 IKBKG [activation] TTC17 ACVR1 [activation;inhibition] PTPRC SLAMF1 [activation] LRRC4C DFNB31 [activation] ACTG1 TNFRSF1B [activation] HSPA1L CBL [inhibition] LDLR FLT1 [activation] SFN PLEKHF2 [activation] PIK3R2 STAB1 [activation] RAB7A TRAF6 [activation] CRKL DCBLD2 [activation] KPNA3 HSF1 [activation] MLKL PBX2 [activation] CAMK2D CDKN1A [activation] GAB1 PTK6 [activation] MDM2 UBTF [activation] LRRK1 PAK4 [activation] 页 106 共 454


2016/4/8 19:14

IPO5 NUP214 [activation] PRMT5 SMARCA4 [activation] TLR4 TOLLIP [activation] PDCD6 DAPK1 [activation] RAN ASAP2 [activation] LYN CSF3R [activation] IL37 CASP1 [activation] HSPB1 MAPKAPK2 [activation] HSPB1 LRRK2 [activation] TRAPPC8 TRAPPC2L [activation] ANAPC16 ANAPC1 [activation] ITGA2 COL1A2 [activation] TP53 RPS15 [activation] CDK2 NPDC1 [activation] SKI MYB [activation] FIBP MIF [activation] RGS8 GOLGA2 [activation;inhibition] ATF2 DDX39B [activation] CD3E EPS8L3 [activation] PYHIN1 NBN [activation] HCK ACTB [activation] CD4 HLA-DQA2 [activation] TNFRSF13B CAMLG [activation] PLAU SERPINF2 [activation] AP5B1 CAMK2B [inhibition] GIMAP6 GABARAPL2 [activation] EIF4G1 ANXA5 [activation] VCAM1 SRI [activation] SGK1 CREB1 [activation] RAD51C NEDD8 [activation] KMT2A CTR9 [activation] EIF4A2 RPAP2 [activation] NSD1 PPARG [activation] NR4A1 VHL [inhibition] TWIST1 TP53 [activation] SPHK1 CTSB [activation] SREBF2 EGR1 [activation] GCG GCGR [activation] EP300 N4BP2 [activation] COX17 TP53 [activation] MAVS IRF3 [activation] LIN37 HIST1H4A [activation;inhibition] SRC PLSCR1 [activation] EGFR CSNK1A1 [activation] SLC8A3 PPP3CB [activation] MAP3K5 PRKAA2 [inhibition] PRMT2 RB1 [inhibition] ESR1 EIF4G3 [activation] GABARAPL2 HSPA4L [activation] KLK9 TGFB1 [activation] TRAF2 XIAP [activation] RPA2 CTTN [activation] HSPB1 SLC7A9 [activation] ABL1 USP7 [activation] CDK4 PRMT5 [activation] SP1 CCND1 [activation] SIRT2 MYOD1 [activation] PLCD1 APP [activation] AKT1 KAT2B [activation] GIT1 ADRBK2 [activation] ATP1A1 ATF2 [activation] NEK6 SMC2 [activation] PPP1CA RPAP3 [activation;inhibition] SERPINC1 KLK6 [inhibition] ESR1 MED1 [activation] TRAF3 SNAP29 [activation] MYO1B CIAO1 [activation] ICT1 SLX4 [activation] FBLIM1 HIST1H3A [activation] SH2D1B TRIM54 [activation] HSPA2 TRIM38 [activation] PML NFKB1 [activation] SRPK2 VRK1 [activation] SAT1 EPHB6 [activation] HCK ERBB3 [activation] BCL2L12 HSPA4 [inhibition] 页 107 共 454


2016/4/8 19:14

ACTR3B RBL1 [activation] FGFR1 NCAM1 [activation] NCOA2 PPARG [activation] ZFYVE20 MAPK14 [activation] GCN1L1 CDC5L [activation] HDAC1 CIITA [activation] YPEL3 SRPK2 [activation] GLRA2 DDX24 [activation] TP53 PAXIP1 [activation] SMARCB1 CCNE1 [activation] FARS2 G3BP2 [activation] ACP5 RPA2 [activation] PTPRO WAS [activation] CSNK1A1 PPP2R5A [activation] GRIA4 GRIA1 [activation] HSPB1 MAP1LC3B [activation] RAB2A ATF2 [activation] LILRB1 HLA-B [activation] SAV1 CSNK1E [activation] ZAP70 CARD11 [activation] HSP90AB1 KCTD8 [activation] PPARG STMN1 [activation] DNM1L ESR1 [activation] PCNA ATF2 [activation] MAP3K4 AXIN1 [activation] PIK3R1 GRB10 [activation] HSF1 MAPK3 [activation] FOS RPS6KA2 [activation] SFN CBL [activation] NOTCH2 ST14 [activation] GLIS2 CTNNB1 [activation] FANCG FANCE [activation] EIF3CL STK4 [activation] RHOQ CDC42EP1 [activation] CASP3 MDM2 [activation] ELAVL1 MICB [activation] PHLPP1 BTRC [inhibition] ZBTB8OS PRKCH [activation] HDAC1 E2F4 [inhibition] PDX1 SPOP [activation] MAP3K1 BRAF [activation] ARRB2 CTNND1 [activation] NPW NPBWR2 [activation] HSPB1 AATK [activation] SMC4 RPA3 [activation] VANGL2 DVL1 [activation] ARHGEF4 APC [activation] SMARCA5 CEBPB [activation] TP53 TUBB [activation] FOS TSPAN2 [activation] YWHAZ APC [activation] ARHGDIA VAV1 [activation] FOS ATRNL1 [activation] SGK1 IKBKG [activation] TP73 MAPK8 [activation] BAD S100A10 [activation;inhibition] ADSS HLA-B [activation] CAMK2B ETS1 [activation] CD48 LCK [activation] ARRB1 TRAF6 [activation] LIN52 LIN54 [inhibition] MDH1 HSP90AB1 [activation] FOXC1 PITX2 [activation] EZH2 MAP3K7 [activation] EP300 GPBP1 [activation] SLFN11 RPA2 [activation] NFKBIA UBE2I [activation] YWHAG LUC7L2 [activation] GHR DUSP7 [inhibition] EGFR NCL [activation] NARF SFRP4 [activation] ATP1B1 NR3C1 [activation] NLK BACH1 [inhibition] CSNK1G3 DBNDD2 [activation] YY1 ACTB [activation] CAPRIN1 MDM2 [activation] 页 108 共 454


TNFAIP3 CHUK ACTG1 DNASE1 GNAI2 IGF1R SMAD2 DLX4 IL2 IL2RG WAS SRGAP2 ESR1 GNAI2 TGFBR1 DAPK2 TNFRSF11A FZR1 GRIA1 ASS1 LATS1 CDH1 BLID LNX2 MAPK9 ATG5 RBBP4 ABI2 VARS2 CAMK2D BANP PDE3B PIK3CG HDAC1 PPP1CC RPTOR FKBP1A AGPAT1 MYC CASP3 NMT2 YWHAH VAMP8 MAPK14 NFATC4 UBAC2 GCN1L1 SNAI1 TTC25 JAK2 G3BP1 PNO1 TRAF6 GAPVD1 YWHAB CUL1 BCL6 DNM1 PRKCA CAPNS1 AGTRAP KCTD17 RWDD4 OSGEP SHC1 KISS1 MMP2 BCL2L1 HRK SPHK2 FHL2 YWHAQ NFATC1 DLG3 CAMK2A GABARAPL1 GAB1 SUPT6H AKAP8 LRRK2 MTFR1 DUSP23 ACP6 RSU1 CTNNA1 FBP2 L1CAM NUMB ETS1 SP100 RALBP1 CCNB1 CALM1 MBP TRIM28 ARF6 CDC23 ANAPC1 PIK3R2 TGFBR1 IARS SGK1 CDC42 RIF1 LZTR1 HDAC4 PKIB PRKACB SMAD4 FOXO4 HIST1H2AG MTOR SIRT1 DDX39B ZHX1 SMAD7 PARD3 TP53 CDK1 SPP1 KCNIP1 CDK5RAP2 OLFM4 NOD1 TRAF6 PPP2CB RASA1 DCC CDCA8 XPO1 RASGRF1 SNRNP70 POFUT1 JAG1 PRSS50 STK11 H2AFX ANXA2P2 FGFR1 GRB14 RNF34 TP53 SP1 FYN PCYT1B ACTB TNFRSF10B

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[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] TRAF5 [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] ANXA1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] YWHAZ [activation] [activation] [activation] [activation] [activation] [activation] TUBGCP6 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] EGFR [activation] 页 109 共 454


2016/4/8 19:14

RPL7 TP53 [activation] SRPK1 CDK7 [activation] AXIN1 SMURF1 [inhibition] IRF4 NFATC2 [activation] HDAC6 MYD88 [activation] NUDCD3 EIF2AK4 [activation] LAT GRB2 [activation] TSC2 MAPKAPK2 [activation] N4BP2 BCL3 [activation] TWF2 KRT31 [activation] LATS1 MAST2 [inhibition] GRAP BCR [activation] PKM CD81 [activation] PIP4K2B EPB41L3 [activation] APP RABL3 [activation] SRC ERBB3 [activation] EGFR RET [activation] VDR NCOA3 [activation] BARD1 CDK1 [activation] EXOC5 PYCARD [inhibition] LRRK2 MDN1 [activation] CREBBP SUV39H1 [activation] PKM RELA [activation] KLK7 PTPN1 [activation] TFPI MMP9 [inhibition] CEBPB DDIT3 [activation] STK4 ARF1 [activation] CEP55 CDK1 [activation] RAC3 RWDD1 [activation] POLA1 PARP1 [activation] KPNA1 FOSL1 [activation] RET NRTN [activation] A2M CDC42 [inhibition] TPD52L1 HDAC1 [activation] TAGLN2 HLA-B [activation] PML SP1 [activation] ICAM1 FAU [activation] IL9 SNTA1 [activation] CXCR4 PECAM1 [activation] MCM6 CCND1 [activation] PRIM1 MRPL38 [activation] GRM3 GRASP [activation] TNFRSF21 WASH2P [activation] ARRDC3 UBE2E2 [activation] RFX6 DGCR6 [activation] XPOT MYC [activation] CACNA1A C1QTNF1 [inhibition] GABARAPL2 PFN1 [activation] TRAF5 TRAF3 [activation] RFXAP SMARCA4 [activation] ANXA7 ANGPT2 [activation] TRIM28 NR3C1 [activation] DUSP1 SUMO3 [inhibition] PSEN2 CAPN1 [activation] PPIF ABI2 [activation] ATF3 HDAC1 [activation] ICT1 MRRF [inhibition] BCL2L1 TPT1 [activation] GRB2 HIST1H4A [activation] APC CASC3 [activation] CCL7 MMP3 [activation] GATA2 ZFPM1 [activation] EXOC4 WASH1 [activation] NFKBIA PTPN13 [activation] DVL1 TRIM69 [activation] DVL3 WT1 [activation] BMP2 ASCL1 [activation] KANSL2 APP [activation] NANS PDGFRL [activation;inhibition] FAM178A CALM1 [activation] PTEN SMTN [activation;inhibition] PLK1 SNW1 [activation] APBB3 EGFR [activation] AHNAK ATF2 [activation] NPHP1 PTK2B [activation] AUP1 OPRM1 [activation] 页 110 共 454


2016/4/8 19:14

HES1 FANCL [activation] TTN OBSCN [activation] PDGFB THBS1 [activation] PTBP3 RAB23 [activation] TAS1R1 TAS1R3 [activation] FOS LMO3 [activation] FOS GNL2 [activation] RPA2 C7orf50 [activation] CREBBP CSNK2A1 [activation] USH1C RAC1 [activation] RAC1 CNTNAP1 [activation] IGF1R NAT2 [activation] MYC NMI [activation] ACACA SHC1 [activation;inhibition] NDRG1 MLH1 [activation] NFKB2 SMARCA4 [activation] PIGR CD79A [activation] BCL2 RRAS [activation] COL4A5 APP [activation] ENO2 GABARAP [activation] HLA-B CDKN2A [activation] AR SPDEF [activation] VAMP8 VAMP3 [activation] LRRK2 SPIN1 [activation] PLXNB1 RAC1 [activation] HSPG2 PDGFB [activation] HNF1A CTNNB1 [activation] BIRC3 IKBKB [activation] IRS4 HSPA4 [activation] HIST1H2BL ICAM1 [activation] RANBP10 MET [activation] HIPK2 PTCH1 [activation] KAT2B JUN [activation] INADL KCNJ2 [activation] HIST1H2BJ ICAM1 [activation] YTHDC2 AXIN1 [activation] NOS1AP FAM133A [inhibition] AKAP9 CDK5RAP2 [activation] TULP3 CCNB1 [activation] FLNA GRB2 [activation] SLC23A3 IGF1R [activation] ADORA2A CNR1 [activation] PRKCQ HSP90AB1 [activation] CDC25B SFN [activation] GRB2 MYL12A [activation] LAMA4 PTN [activation] ARHGEF6 SMAD2 [activation] NCF4 PRKDC [activation] DYRK1B MAP2K3 [activation] MAP1LC3B DDX24 [activation] TRIM16 NXF1 [activation] HIST3H3 JADE3 [activation] MEP1B PRKACA [activation] CPE CCK [activation] CXCR4 JAK1 [activation] GNB2 GNAI3 [activation] PRKCI FRS2 [activation] KIAA0930 YWHAE [activation] CAPN10 FANCC [activation] PGK1 HSPH1 [activation] CCL5 DPP4 [activation] USF1 ESR1 [activation] LRRK2 PTPN23 [activation] PRKCD PPM1A [activation] NOTCH2NL HSPA12B [activation] ACACA STK3 [activation;inhibition] ERBB4 ITCH [activation] HSP90AB1 SGK1 [activation] FGF2 PF4 [activation] STIP1 ATF2 [activation] JUN UBE2I [activation] CASP10 RIOK3 [activation] NCKAP5 APC [inhibition] HES1 HMGB1 [activation] EPOR PTPRC [activation] ILK CDIPT [activation] 页 111 共 454


2016/4/8 19:14

EDN3 CMA1 [activation] PRKDC PPP6C [activation] ZNRF1 UBE2E3 [activation] GSK3B STYK1 [activation] STK3 MPP1 [activation] PAXIP1 SRSF5 [activation] MCM3 HLA-B [activation] GAS7 DIAPH1 [activation] DDX21 GH1 [activation] ATF2 APP [activation] BRAF AKT1 [activation] SIRT1 EPAS1 [activation] WNT2 HCK [activation] LGALS9 CTNNB1 [activation] FAM154A STK16 [activation] RAB11A RAB11FIP5 [activation] BMPR1A MAP2K1 [activation] YWHAE SRSF6 [activation] ESR1 GSN [activation] ANAPC10 ANAPC11 [activation] POU1F1 NR1I2 [activation] C5 C7 [activation] NFKB1 MTPN [activation] AURKB HSPA5 [activation] EGFR SNX9 [activation] GNAQ GALR2 [activation] SIRT1 HSF1 [activation] KDM4D TP53 [activation] LHX1 ISL1 [activation] ROBO4 SLIT2 [activation] ASB18 ASS1 [inhibition] AR VAV3 [activation] PELI2 MYD88 [activation;inhibition] TTC17 SMURF1 [inhibition] CTBP1 CDC23 [activation] RGS12 GRM5 [activation;inhibition] DYRK1A HIST1H4A [activation;inhibition] AUTS2 EP300 [activation] HP1BP3 PAXIP1 [activation] ATF4 ATF2 [activation] A2M ADAMTS7 [inhibition] TNFRSF14 DCD [activation] ADRB2 MAGI3 [activation] NUMA1 WHSC1 [activation] ATF4 NXF1 [activation] GNB2 EGFR [activation] GRB2 CD22 [activation] CCDC8 MARS [activation] CFL1 TAB1 [activation;inhibition] FBXO6 ASS1 [inhibition] PTGFR PTGER2 [activation] SIRT1 STAT3 [activation] EP300 MAP2K1 [activation] H2AFX POFUT1 [activation] APC BUB1 [activation] CDK11B CASP1 [activation] ULK1 MAP1LC3A [inhibition] CCDC114 CCDC151 [activation] GATA1 RADIL [activation] WIPI1 AR [activation] VCAM1 XPO1 [activation] ITGB1 LAMTOR5 [activation] CDC7 CLSPN [activation] CDK4 HIST1H1D [inhibition] BLK ATP5O [activation] APP FMNL1 [activation] SGTA MOS [activation] CEBPA CDKN3 [inhibition] PRKAA1 ABI2 [inhibition] EIF2B5 GSK3B [activation] ETS1 CAMK2A [activation] EIF2B1 WDYHV1 [activation] PHGDH MAPK13 [activation] PIN1 TAB3 [activation] INSIG1 PGRMC1 [activation] DDX5 SMAD1 [activation] 页 112 共 454


ATAD3C DDX19B PRMT1 MAFK MAGEB4 CDC5L CASP2 ANXA6 MYBPC2 GRAP NXF1 RICTOR SMURF1 BAZ1B FLT1 PROS1 NOS3 GNAI2 PARD6A PRKAR1A APP CREBBP APP ITGB4 KLHL29 KIT FASLG GLTSCR1 HIF1A FANCF SRC PIK3CA PRKCA RAX CPB2 FAAP24 PPARG DRD2 SUMO1 CYLD PPP3CB PIAS3 LRRK2 PIAS2 BCL2L1 VCAM1 SYT1 SP1 BCL2L2 NCK2 RNF114 STX4 CSF3R C2 IGSF21 GADD45G ITGA4 CRKL MAPK12 BLNK MSTN SIRPB1 EXOC6 TSC2 MAPK8 CTNNB1 NR2E3 DNAJB11 ATM SMAD3 RAC1 NREP SYK MDM2 PIK3CB HBQ1

2016/4/8 19:14

ESR1 [activation] ARF6 [activation] TRAF6 [activation] NFE2 [activation] USHBP1 [activation] BRD4 [activation] RXRA [inhibition] GRB2 [activation] CMYA5 [activation] SOS1 [activation] LAMTOR5 [activation] IKBKB [activation] GRIPAP1 [inhibition] PHLDA3 [activation] PTK2B [activation] F8 [inhibition] PSEN1 [activation] LTB4R [activation] LLGL2 [activation] CDK4 [inhibition] MKNK1 [activation] MAFK [activation] PPAP2B [activation] SEL1L [activation] NUDCD3 [activation] CBL [activation] PSTPIP1 [inhibition] GRB2 [activation] HSP90AB1 [activation] OLFM2 [activation] FBXO18 [activation] APLP2 [activation] KCNQ2 [activation] PAX6 [activation] C5 [activation] APP [activation] APP [activation] GIPC1 [activation] DHTKD1 [activation] PMS1 [inhibition] PPP1R13B [activation] HMGA2 [activation] DBF4B [activation] MAPKAPK2 [activation] PDIA4 [activation] HIST1H2BL [activation] SNAP25 [activation] POU2F1 [activation] BCL2L11 [activation] CHN1 [activation] UBE2H [activation] SCRIB [activation] STAT3 [activation] C5 [activation] HSPB1 [activation] GDF9 [activation] HNRNPD [activation] ARHGEF5 [activation] SRPK1 [activation] BTK [activation] WFIKKN2 [activation] SYK [activation] PSEN2 [activation] ESR1 [activation] TNFRSF1A [activation] ERBB2IP [inhibition] RXRB [inhibition] DNAJC13 [inhibition] CDC6 [activation] DDX5 [activation] PLCG1 [activation] ATM [activation] ITGB2 [activation] LATS1 [inhibition] ERBB3 [activation] HBD [inhibition] 页 113 共 454


APITD1 HOMEZ CNR2 GNA15 EGFR BMX DOK3 YWHAE AURKB CALM1 MDFI GNAI2 CDK9 CDK5R1 RARA CCND3 SIRT5 RELA RASA1 BIRC5 NDUFS7 ENO2 PARD6G PRKCI ADCYAP1 CASP2 CREBBP CUX1 ILK FASN MCF2L2 MEGF10 CEBPB NR5A1 CTNNB1 FSCN1 CISH PRKCB IRF4 BCL6 SMAD1 HIPK2 PTK2 CD79B CKS2 CCNB1 CHERP SRPK2 EIF1B RHEB ICAM1 EIF3CL DDX51 MYC TRIM24 NCOA1 FANCD2 HELQ DIABLO BIRC6 ATG5 NUDC HLA-B CYB5B EHMT2 XAGE2 CTR9 BLK MAP2K4 CDC5L TBK1 PPP6C FGFR1 PPP2R1B ATR POLD1 DRD2 CALM1 APPL1 EGFR EGFR ATP2B4 HSP90AA1 DAB1 PTPN11 NOTCH1 SLFN11 EPHB2 MLLT4 NOTCH1 RELA GRB2 AGER ITK EGFR AKT1 SOAT2 SRRT STAT3 SHC1 CALD1 AGTPBP1 CYCS APP ABR SDC2 TIAM1 FBXO6 HLA-C RET DOK2 NUDC MLST8 PGAM5 XIAP CTSB MLH1 SFN FAM9B F7 DMWD RNF32 MGEA5 SAA1 FPR1 TRPT1 TRAF2 KLK6 COL4A1 A2M TGIF1 SCARB2 CSK NOTCH1 WDR6 TIPARP ATM SMURF1 HSPA8 RNF216 RIPK1 TFRC B4GALT1 PPP1CC TPRN SPG20 SMAD2 C4BPA GIT2 CRKL WAC

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[activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] ICK [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [inhibition] [inhibition] [activation] 页 114 共 454


2016/4/8 19:14

CASP8 BCAP31 [activation] CCDC53 SNAP25 [activation] WWTR1 CTNNB1 [activation] ACACA CHGB [activation;inhibition] FGFR1 SH3BP2 [activation] CBLB CBL [inhibition] GEM LZTS2 [activation] CCNG2 PPP2R5B [activation] HIST2H3A PCNA [activation] STC2 PEBP1 [inhibition] HNRNPD ICAM1 [activation] PTPN1 IL1B [activation] KAT2B NCOA4 [activation] AGTR1 RAB5A [activation] PAK2 BTF3 [activation] WDR17 ETS1 [activation] FLT1 ATR [activation] CCNB1 RELA [activation] HNF1A RAC3 [activation] NSD1 HIST1H1D [activation] AMBRA1 MTOR [activation] UBC CSF1 [activation] EGFR PAK1 [activation] HSPA8 GAK [inhibition] PPARG RANBP9 [activation] IFITM3 GLP1R [activation] YWHAE SIK3 [activation] STAT5B TFG [activation] PLXNB1 RHOA [activation] RAF1 LRPAP1 [inhibition] SRC CDC25C [activation] GSTP1 MAPK1 [inhibition] GIT2 HGD [activation] JUP CDK15 [activation] CHRM2 ELAVL1 [activation] RPA1 MCM7 [activation] STMN3 GLP1R [activation] CBLB UBASH3B [inhibition] VAMP2 PRKD3 [activation] HDAC1 ATR [activation] STK11 HSP90AB1 [activation] SRPK1 PPIL1 [activation] HPS6 PIK3CB [activation] PMAIP1 BCL2L1 [activation] DDX17 CTCF [activation] ATG12 DDX58 [inhibition] TH MAPK3 [activation] PPP2CA STK24 [activation] LHB CGA [activation] MSL2 YWHAZ [activation] CRK ASAP2 [activation] TYK2 PDGFRB [activation] MLH1 TMSB4X [activation] SCAMP5 VAMP4 [activation] CSN2 FHL2 [activation] SMAD7 KAT2B [activation] SRPK2 DDX50 [activation] TP53 CTBP1 [activation] GNAI2 P2RY12 [activation] SIX3 TLE3 [activation] SLC9A3R2 PDPK1 [activation] TENM1 SORBS1 [activation] SRPK2 HNRNPC [activation] COL1A1 COL1A2 [activation] MAPT HSP90AB1 [activation] HMGB1 RBPJ [inhibition] ATF6 CREB1 [activation] IRS1 IL4R [activation] SNCG FAM90A16P [inhibition] NCDN GSTK1 [activation] METTL3 METTL14 [activation] PAK2 TNK2 [activation] GYS1 APP [inhibition] PDGFRB ITGB3 [activation] MLH1 AMOT [activation] CALM1 ESRRG [activation] 页 115 共 454


2016/4/8 19:14

HIST1H4A SUV420H1 [activation] STAT5B INSR [activation] ICAM4 ITGA4 [activation] DIAPH1 WBP4 [activation] PAXIP1 SKA3 [activation] GSK3B GNB2 [inhibition] BAK1 GIMAP5 [activation] SLC25A4 E2F3 [inhibition] NUMB PRKCG [activation] FANCG FSCN1 [activation] PRKCB AKT1 [activation] LATS1 MOB3C [inhibition] RELA DNAJA3 [inhibition] FTSJ1 CDKN2A [activation;inhibition] FN3KRP APP [activation] FAAH2 APP [activation] TP53 CCL18 [activation] PPP3CB SLC8A2 [activation] IKBKG TRAF6 [activation] MAGOH RAN [activation] PRKCA GABRB3 [activation] CIT RND3 [activation] WDFY2 NUDC [activation] VEGFA EPHB2 [activation] EIF4A2 ECT2 [activation] ZNF32 GRB2 [activation] PRKD2 IFNAR1 [activation] TBK1 RARA [activation] POU5F1 ETS2 [activation] RBL1 TFDP1 [inhibition] EIF2S1 MAST3 [activation] NR3C1 NRIP1 [activation] ADNP HIST3H3 [activation] NXF1 DDX5 [activation] CEBPE E2F1 [activation] MAP2 MDM2 [activation] SLX1A ANXA1 [activation] ATM SMAD7 [activation] LZTS2 CCNG1 [activation] MAPK8 RAF1 [activation] PPP1CA H2AFX [activation] PAK2 SH3RF1 [activation] LRRK2 DHX16 [activation] YWHAG CASP3 [activation] AKT1 MTCP1 [activation] BAK1 BCL2A1 [activation;inhibition] DUSP13 ACVR1 [activation;inhibition] H3F3A CCDC71 [activation] BIRC3 BIRC2 [activation;inhibition] MCM3 NFKBIA [activation] CREBBP STAT5A [activation] ATF2 COLGALT1 [activation] EGLN1 KRAS [activation] PRKAB1 EPB41L5 [inhibition] GMEB1 CASP8 [inhibition] ABL1 PAK2 [activation] EEF2K RPS6KA1 [activation] RPA1 CCNA2 [activation] CSNK1A1 ACACA [activation;inhibition] CCND1 FBXO4 [inhibition] DDX5 STK24 [activation] CDH1 SKP2 [activation] EGFR GPM6B [activation] CRY1 LTBP4 [inhibition] BCL2L11 AURKB [activation] GREM2 BMP4 [activation] PPP2R4 CCNG1 [activation] SFN MARK3 [activation] RHOA ARHGEF19 [activation] FBXO6 COL6A1 [activation] NDEL1 YWHAE [activation] MYOG PRMT5 [activation] RAC1 RTKN [activation] PDCD6IP GRB2 [activation] JAG1 FBXW7 [activation] DUSP15 PLCG1 [activation] 页 116 共 454


2016/4/8 19:14

PRKCZ HIST1H1B [activation] MAP1LC3B RANBP2 [activation] TRIP4 RXRA [inhibition] PPP3CB IRF2 [activation] CMSS1 S1PR1 [activation] TRIM39 UBE2E2 [activation] AK8 CCDC102B [inhibition] ATM RHEB [activation] AR ETV5 [activation] RIMS4 SRPK1 [activation] SLFN11 EGFR [activation] RASA1 STAU1 [activation] WNT4 PORCN [activation] XRCC2 BLM [activation] NOS1AP SYN2 [inhibition] STAU1 MAPT [activation] CRK GRB2 [activation] APP ADAM17 [activation] UBE2I SOX9 [activation] NFKB1 RPS6KA5 [activation] STRAP BARD1 [activation] CXCL12 CTSG [activation] FOXO4 ESR1 [activation] HIST1H1A GZMA [activation] EP300 ASCL1 [activation] PRNP DPP6 [activation] ENKD1 SPERT [inhibition] ARHGEF7 WAS [activation] VAMP8 VAMP2 [activation] FZR1 ANAPC10 [activation] PRKAA2 AMOT [activation] YWHAH SLC25A6 [activation] JAK1 FER [activation;inhibition] KIT GRB7 [activation] SGK1 CAMKK1 [activation] HCLS1 CASP3 [activation] TIE1 PTPRC [activation] BANF1 HLA-B [activation] BUD13 MCM7 [activation] SMAD3 CBL [inhibition] CDC37 AURKB [activation] PLK1 MCM7 [activation] YES1 ITGB4 [activation] PARP1 CD86 [activation] TP53 NFYA [activation] SIRT1 WDR70 [activation;inhibition] CDKN1A TRRAP [activation] CSK PTPRC [activation] DLX1 SMAD4 [inhibition] SMAD2 SENP2 [activation] APP APOE [activation] ARFGEF2 FKBP2 [activation] EP300 LEF1 [activation] MAL SRC [activation] TP53 YWHAE [activation] PRKCD EGFR [activation] PRPF6 MYC [activation] GOLGA2 TSSK3 [activation] APEX1 HIF1A [activation] KMT2A MAP3K5 [activation] ACOX1 SCP2 [activation] CDCP1 PRKCD [activation] RPS6KA5 DNAJC11 [activation] NDRG1 CDH1 [activation] ARRDC1 ADRB2 [activation] ILK HSPE1 [activation] CARD11 MAP3K7 [activation] P2RY2 KDR [activation] RPA1 BCAP31 [activation] GRB2 HELZ [activation] TRAF1 CASP6 [activation] RAN SMARCB1 [activation] NFE2L2 CREBBP [activation] FOS CREBBP [activation] IRF7 SMAD4 [activation] GNAI2 TTC1 [activation] 页 117 共 454


2016/4/8 19:14

STAT6 NFKB1 [activation] TP53 TRIM24 [activation] MLXIPL NIF3L1 [activation] RARB RXRA [inhibition] ATG4D CASP3 [activation] TSR1 RPA3 [activation] RAB1A RPA3 [activation] HSP90AB1 PIM3 [activation] GATA4 SRF [activation] NR5A1 MAPK1 [activation] NRXN1 ATP13A2 [activation] PPARA GADD45A [activation] EIF4A1 GABARAP [activation] PTEN STK11 [activation] STK11 PTGES3 [activation] STRAP HLA-B [activation] GATA3 FOXA1 [activation] ITGA4 RCC1 [activation] IL33 HIST2H2AA3 [activation] TP53 CDKN2C [activation] GAB2 GAB1 [activation] PDGFA SPARC [activation] POLA2 POLA1 [activation] TP73 CDK2 [activation;inhibition] TRAF3 ARRB2 [activation] NR4A1 YWHAZ [inhibition] MAD2L1 PPP2R5D [activation] APP TRIB3 [inhibition] TIAM2 TNIK [activation] RAB2A MAPK6 [activation] WFIKKN1 BMP8B [activation] HIST3H2A ITGA4 [activation] PRKCD PPARA [activation] MDM2 FAM171A1 [activation] KLHL12 PDGFRB [activation] NRBF2 ULK1 [inhibition] C3 CFB [activation;inhibition] YWHAZ SIK2 [activation] TP53 PTTG1IP [activation] SHC1 PRMT5 [activation] RALGAPA1 MYC [activation] CFL1 ISG15 [activation;inhibition] RAD51 SIRT2 [activation] SRGAP2 FASLG [activation] YWHAZ RAP1GAP [activation] RHPN2 SFN [activation] EGFR IRS2 [activation] ZFYVE9 ETS2 [activation] NFKBIA MAP3K14 [activation] ZAK SMARCB1 [activation] TBXA2R RHOA [activation;inhibition] DAB1 APLP2 [inhibition] SARM1 MYD88 [activation;inhibition] AGAP3 HSPB1 [activation] MAX MGA [inhibition] FIS1 NOS3 [activation] JMY MDM2 [activation] PPP2CA CTTNBP2NL [inhibition] EGFR NCAPG2 [activation] IKBKE PAK1 [activation] YWHAZ WWC2 [activation] RANBP2 SP100 [activation] KNG1 CTSS [activation] JAK1 IL7R [inhibition] AZI2 TBK1 [inhibition] MIF BCL2L11 [activation] IRF9 STAT1 [activation] RNPEP ZFYVE9 [activation] XRCC3 SCGB3A1 [activation] RRAGA RRAGC [activation] ITGAV PXN [activation] EIF4A3 ZC3H11A [activation] TRAF6 HARS [activation] SGK3 SLC9A3R2 [activation] TNFRSF14 ATXN10 [activation] MAPK13 MBP [activation] 页 118 共 454


2016/4/8 19:14

EGFR THEM6 [activation] GNAO1 APP [activation] APC TFF1 [activation] SRPK1 CDKL3 [activation] MAST1 YWHAE [activation] RAC3 DDX46 [activation] MARCKS CCNE1 [activation] RAD50 KAT2A [activation] DHX37 MYC [activation] AURKA USP9X [activation] ITIH5 NOTCH2 [activation] APBB1 ABL1 [activation] DTX3 UBE2E3 [activation] CDKN2A HIPK4 [activation;inhibition] RAB10 ASB17 [activation] NUDT16L1 TP53 [activation] ELMSAN1 MAPK14 [activation] ESR1 BCAR1 [activation] EGFR ARFGEF1 [activation] DOCK9 TAF1 [activation] PPP2R1A RAB11A [activation] IRS2 GRB10 [activation] CDH5 P2RX6 [activation] LAMB2 PLEKHA5 [activation] HSP90AB1 YWHAB [activation] NMES1 ABL2 [activation] ESR2 FBLL1 [activation] KIF7 CCDC8 [activation] HIF1A MCM7 [activation] PON2 EGFR [activation] PPP2R1A CCDC8 [inhibition] EIF2B1 EGFR [activation] IL1RAP IRAK1 [activation;inhibition] LARGE B3GNT1 [activation] TGM2 HIST3H3 [activation] AFF2 GRB2 [activation] C1orf109 NXF1 [activation] DLX5 HOXC8 [activation] GABARAPL2 ENO2 [activation] MYB FBXL5 [activation] COL4A6 DCN [inhibition] MS4A1 CCDC155 [activation] PRKACA WASF1 [activation] NUPL1 APC [inhibition] KAT2B TWIST1 [activation] ANGPT2 CSNK2B [activation] PI4K2A GABARAP [activation] YWHAE WNK1 [activation] FCGR2C ITGA4 [activation] PPP1R3A PLN [inhibition] SNCB SNCA [activation] TLX3 PPP1CC [activation] MAML3 MAML1 [activation] CLCF1 ESR2 [activation] FAS TRAF3 [activation] PYY MEP1B [activation] C1QB PTX3 [activation] ROBO1 SRGAP2 [activation] CASP6 CASP10 [activation] MIEF2 DNM1L [activation] NBEA NOTCH1 [activation] BMPR1A RASA1 [activation] NIF3L1 DMC1 [activation] THOP1 TRAF2 [activation] PRR5L RICTOR [activation] RARA NCOA3 [activation] PLEC ITGA4 [activation] ZNF321P SRPK1 [activation] NCF1 NFKB1 [activation] CREBBP YWHAH [activation] RLN3 RXFP4 [activation] FYN HOXC8 [activation] MAPT CASP7 [activation] POLA2 STK40 [activation] ATF2 MAPKAPK5 [activation] KIR3DS1 TYROBP [activation] 页 119 共 454


2016/4/8 19:14

TMSB4X ACTG1 [activation] PIK3CD TAGLN [activation] TGFBR3 ENG [inhibition] GRB2 HIST1H2BH [activation] MAPKAPK2 ZFP36 [activation] CD44 MET [activation] NGFR LINGO1 [activation] PRKAA1 HMBOX1 [inhibition] PDGFRB SH2B2 [activation] IQGAP1 MYC [activation] FOS GATA4 [activation] HSP90AA1 VCAM1 [activation] TIAM1 SDC1 [activation] NAPB STX6 [activation] CSNK2A1 FGF2 [activation] RAB21 APPL1 [activation] L1CAM FBXO6 [activation] STRAP GSK3B [inhibition] ROCK2 CDC5L [activation] SKP2 YY1 [activation] NFKB1 CALM1 [activation] ADAM9 TNF [activation] NEB PTPN11 [activation;inhibition] GFOD1 NOTCH2NL [activation] TELO2 ATM [activation] PRDX2 RAD52 [activation] CD4 ANXA6 [activation] TFDP1 E2F2 [inhibition] TNF TNFRSF1A [activation] CHEK2 STMN1 [activation] ATP6V1H SOX9 [activation] POFUT1 NOTCH1 [activation] RYR1 HOMER3 [activation] SLC9A3R1 PLCB1 [activation] MAD2L1 CUL3 [inhibition] LRIF1 FAS [inhibition] PTN ACTB [activation] VAV1 EZH2 [activation] STXBP1 STX4 [activation] CTNND2 SPHK1 [inhibition] UBE2H TRAIP [activation] ESR2 SCRIB [activation] MAP2K1 BIRC6 [activation] EIF2S2 DCC [activation] IKBKE RHOC [activation] TNFAIP3 WNK1 [activation] RASA4 ERBB3 [activation] PRPF40A DIAPH1 [activation] S100A10 ATF2 [activation] KLF1 CREBBP [activation] KRAS DDX50 [activation] ESRRA NR0B1 [activation] ANXA2P2 ESR1 [activation] MET BTK [activation] CDH1 EPSTI1 [activation] SEMA6A SORBS1 [activation] PECAM1 SRC [activation] TNK2 CRK [activation] PIK3R1 EPN1 [activation] FOXO1 HNF4A [activation] PTPRB MAPK3 [activation] CDH2 PTPRB [activation] CDC25B ESR1 [activation] BTRC FOXO3 [inhibition] CEBPB NFKB1 [activation] AR CRK [activation] ADRA1B EZR [activation] TGFBR2 FSTL1 [activation] CDC20B TRAF2 [activation] KCNA2 PTPRA [activation] HDAC1 PIK3R1 [activation] NRAS CORO2A [activation] PDX1 PRKDC [activation] PA2G4 ATG5 [activation] ATG5 ATG3 [activation] ANKRD7 HSPB1 [activation] 页 120 共 454


2016/4/8 19:14

GIGYF2 CD2 [activation] EGF UBE2I [activation] CIAO1 MYO1C [activation] PRMT1 MBP [activation] C9orf156 CCND1 [activation] BHLHE40 PPP2CA [activation] APP MST4 [activation] DLG5 CD81 [activation] RHOBTB2 PPM1D [activation] PTBP3 FTSJ1 [activation] RAC1 ARHGAP27 [activation] NSD1 NR2E1 [activation] CSNK1D LRRK2 [activation] PTPRJ KIT [activation] IGFBP7 CCL5 [activation] CLEC4M TLR2 [activation] RHOT1 ILK [activation] LSM1 PTPRC [activation] CUL3 CDK4 [inhibition] DHPS NIF3L1 [activation] RPA3 COBL [activation] RELA CAMK4 [activation] ETS1 NOMO2 [activation] HSP90AB1 KLHL23 [activation] SFRP4 SMAD4 [activation] DOT1L HIST2H3A [activation] CRK ABAT [activation] PIK3CA ADAP1 [activation] EPHB6 EPHB1 [activation] LAMP2 LRRK2 [activation] CDK3 TFDP1 [activation] PTK2 MAL [activation] YTHDF2 RPA3 [activation] SETDB1 PGAM5 [activation] CCDC97 APBB1 [activation] SMAD3 IRS1 [inhibition] CCND1 CDC14B [inhibition] MAST3 PRKAA1 [inhibition] NXF1 BCAP31 [activation] PIK3R1 EPOR [activation] KAT2B CTBP1 [activation] EGFR FRK [activation] KAT2A RBPJ [activation] PROP1 EFEMP1 [activation] SMAD3 RRAS2 [activation] TWIST1 HIST1H4A [activation] CREBBP RXRG [activation] CASP3 BECN1 [activation] MAPK8 RAC1 [activation] C11orf83 PHLDA3 [activation] CTNNB1 PTBP3 [activation] PSEN1 RNF32 [activation] MYO6 PAK1 [activation] UGT1A1 UGT1A8 [activation] AURKA IRS4 [activation] GADD45G RXRA [inhibition] GRB2 VAV1 [activation] MAP2K1 MAPK8IP3 [activation] PRDX3 LRRK2 [activation] EZR HLA-B [activation] RPA3 BCAP31 [activation] WASF2 FYN [activation] NUDC DCAF4L2 [activation] ITGB1 ACTN1 [activation] IST1 ITGA4 [activation] GDF9 BMPR2 [activation] PDIA2 PPARG [activation] GRB14 PDGFRA [activation] CDKN2AIP RAD21 [activation] TUBG1 CDK5RAP2 [activation] ESR1 XPO1 [activation] C19orf52 APOE [activation] FAM120A NXF1 [activation] CCNA2 CDC25C [activation] PIK3R1 CCL14 [activation] GNB4 ADRB2 [activation] 页 121 共 454


PPP1R12B PSEN1 ICAM5 SSB SPP1 TP53 IRS4 BIRC6 CASP7 DHX34 POLA2 CDH2 BOC GNAQ CCR5 EP300 PRMT1 HSPA4 MDM2 UTP18 KMT2A IRS2 BCL2L1 CD4 ENO1 STAMBP TRAF6 CCDC102B EP300 STRAP A2M ATF7IP BARD1 NPM3 YWHAG CDC25B DVL2 TRAF2 PDGFRB PTPRR TRIM28 SMURF1 SUV420H2 PGK1 YWHAZ CAPN1 BID ABL1 EGFR DYRK1A SFN APPL1 TRAF2 UBE2W RNF138 BRD4 JMJD6 RANBP2 MYC MAPK6 RAB31 VPS35 VCAM1 PPP2CA HUNK EGFR HSPA4 FOXH1 TGIF1 LATS2 SNAI1 HPCA MAP3K10 SMO ILK ICK TP53 CDK6 TRAK1 KIR3DL1 RPS6KB1 ITGB1 PXN VCAM1 TOP1 PML TBX2 MAPT EGFR CALM1 CRHR1 MYOC CD81 ABL1 MAPT PIK3R1 DOCK3 AXIN2 AMER3 WDR96 YWHAE PABPC4 SRPK2 ITGA4 PCBP2 CDKN1A CDKN1B FGA PRRC2A BAG2 LRRK2 TRAF2 MVP LCP2 YWHAZ TFRC ASB4 SOCS3 PTK2B RPS6KA5 STAT1 ABI1 SOS1 PIAS2 CDKN2A SPP1 DCX RAD21 MTA3 DLGAP5 CDK1 C18orf56 RPL13 MAP2K3 SMARCA4 WHSC1L1 FOXO3 SKP2 CTTN ARHGAP8 SRF PYCARD PRKAA1 PPM1E FYN POLD1 ESR1 SFN

2016/4/8 19:14

PPP2R1A [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] ENKD1 [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] RBL1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] PRNP [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] 页 122 共 454


2016/4/8 19:14

BEND5 CTNNBIP1 [inhibition] FOXA3 HMGB1 [activation] HIST2H3A RPS6KA5 [activation] MYO1C ARRB2 [activation] RPS17 VCAM1 [activation] HSP90AB1 ANAPC2 [activation] NR1H2 NCOA2 [activation] PIK3R1 ABI1 [activation] GATC QRSL1 [inhibition] CHUK PIAS1 [activation] RPS6KA5 HSPB2 [activation] NAB2 JAKMIP2 [activation] INSR ARRB2 [activation] PARD3 RASSF8 [activation] HLA-B NACAP1 [activation] SNX5 PIP5K1C [activation] PTP4A3 POLD1 [activation] APP MAB21L2 [activation] HABP4 ENO2 [activation] SIRT7 ACACA [activation;inhibition] CDK11A HSP90AA1 [activation] CDX2 GSK3B [activation] MAPRE1 PRKACA [activation] VASP TES [activation] GATA4 CRIP2 [activation] TRAF6 CALCOCO2 [activation] PTPRC EGFR [activation] CHEK2 KLK9 [activation] LRRK2 NCLN [activation] NDEL1 VCL [activation] TYK2 RAN [activation] PCBP2 MYC [activation] ABL1 SH3BP2 [activation] APC ANKRD28 [inhibition] CD81 HIST1H2BM [activation] RAB11A RAB11FIP4 [activation] ACTR3 GRB2 [activation] MFAP4 GRB2 [activation] PHKG1 CALM1 [activation] BAG3 STMN1 [activation] PIK3CG USP45 [activation] TLR4 HMGB1 [activation] PRKAA2 GLI1 [inhibition] FBXO6 ERO1LB [activation] TNFRSF14 GRB2 [activation] VTCN1 BTLA [activation] ANO5 EGFR [activation] CCHCR1 NAB2 [activation] FBP2 AXIN2 [activation] VAMP3 SCAMP5 [activation] ATM MDC1 [activation] DTX1 EGR2 [activation] CRK GABBR1 [activation] KCNB1 KCNS3 [activation] PTPRC CD28 [activation] ABL1 NOTCH3 [activation] YWHAZ RAPGEF2 [activation] PPP3CA MYOZ2 [activation] MAP3K3 ACTG1 [activation] PAXIP1 KRI1 [activation] PIK3R1 GSPT1 [activation] PXN PDPK1 [activation] ESR1 SRPK2 [activation] PAK3 ITSN1 [activation] RYR2 CALM1 [activation] NR3C1 BAG1 [activation] C3AR1 C4A [activation] TERT ACD [activation] STAT6 MAVS [activation] DIAPH1 SNW1 [activation] LTB LTA [activation] NEDD9 CRK [activation] COMMD9 NFKB1 [activation] DUSP9 GSK3B [inhibition] CD81 CR2 [activation] DDX58 PRKRA [activation] 页 123 共 454


2016/4/8 19:14

ABL1 CDC27 [activation] CSNK1D LURAP1 [activation;inhibition] MYLK PRKG2 [inhibition] CCAR2 TP53 [inhibition] POU1F1 PPARA [activation] KNG1 CAPN2 [activation] SCG2 COPS6 [activation] DSG1 GH1 [activation] LDHB LRRK2 [activation] EIF2AK1 CDC37 [activation] NTRK2 SH2B2 [activation] CD2 CD4 [activation] RHO ADRBK1 [activation] RAP1GAP2 YWHAE [activation] TSHR GNA13 [activation] PAK4 RAC1 [activation] BRCA1 CCNA2 [activation] RPTOR SIRT1 [activation;inhibition] IL1RAP PIK3R1 [activation] KDM6A SRF [activation] ANXA3 IGSF21 [activation] GRIA4 CACNG2 [activation] CHGB RAP1B [activation] SAV1 YWHAE [activation] SRPK1 TNFRSF10C [activation] SOS2 CRKL [activation] PPP1R16A FAM101B [activation] HIST1H1D IRAK4 [activation] GNAI1 CNR1 [activation] CD14 FSTL1 [activation] ATF2 RAB7A [activation] TEP1 TP53 [activation] COPS7A PTGS2 [activation] PAK2 GDI2 [activation] AURKA FBP2 [activation] CD8A HLA-G [activation] BTRC BTG1 [activation] RAC2 NOXA1 [activation] VCAM1 ARF1 [activation] HSPA1L TRADD [activation] GLI1 SMAD2 [inhibition] FLOT1 FYN [activation] GABRB2 PPP3CA [activation] NFYA APP [activation] SH3BP2 GRB2 [activation] CENPA DIAPH2 [activation] NOTCH1 NCKAP1L [activation] NFIL3 TRAF2 [activation] GZMM EZR [activation] IL17A TRAF3IP2 [activation] NFKB1 IL2RA [activation] CDC5L WHSC1 [activation] HDLBP STK4 [activation] OGT TET1 [activation] ATG4C PRKDC [activation] SERBP1 VAV2 [activation] CMA1 EDN1 [activation] PPARGC1A MED1 [activation] MAPK3 MAGED1 [activation] SAMD3 FANCG [activation] EHMT2 PLOD3 [activation] ITGA2B GRB2 [activation] CAPZA1 FAM21C [activation] ACTB RAD51 [activation] VAV3 ESR1 [activation] CCDC155 SENP2 [activation] GDI2 TRAF6 [activation] STX16 STX4 [activation] SLC9A7 SCAMP5 [activation] MAPK3 LRPAP1 [inhibition] IGKV1-5 SLX4 [activation] LAT PTPRJ [activation] PPP1CC ACTG1 [activation] HSP90AA1 EPAS1 [activation] CSF3R JAK2 [activation] TRIP6 S1PR1 [activation] 页 124 共 454


2016/4/8 19:14

IL2RA SNTA1 [activation] SMG5 TERT [activation] TUBA4A ENO2 [activation] MDM2 H1FX [activation] NCK1 CD3E [activation] FZD2 STAT3 [activation] CRK SH3KBP1 [activation] TP53 RANBP9 [activation] NUMBL EGFR [activation] NAA38 VCAM1 [activation] GTPBP1 CDC5L [activation] STAT3 LAMB2 [activation] PRKCA PRKCE [activation] ARNT HIF1A [activation] PCDH9 BCL6 [activation] SAA2 LAMA1 [activation] SOX10 DLX5 [activation] ASB5 ENO2 [activation] OLFM2 SRSF5 [activation] PML RXRA [inhibition] PRKCD PRKCB [activation] BRK1 ROBO1 [activation] APP LPL [activation] SPDYA CDKN1B [inhibition] DDX27 PPP1R16A [activation] VAPA VCAM1 [activation] MAPK13 NUDC [activation] GH1 TMCO1 [inhibition] STK3 GAD1 [activation] RBL1 CDKN1C [inhibition] ABL1 CENPA [activation;inhibition] MAPT MARK4 [activation] FTSJ1 CYCS [activation] PAK7 ARRB2 [inhibition] PGK1 HIF1A [activation] MS4A1 CREB3 [activation] ADAM17 JAG1 [activation] APCS C1QA [activation] RNF8 RAD50 [activation] TP53 TP53RK [activation] PMS2 RASA1 [activation] EPX PLCG1 [activation] FYN PECAM1 [activation] SUFU PIAS1 [inhibition] TSSK6 HSP90AA1 [activation] FANCI CAMKK2 [activation] WNK4 KLHL2 [activation] SUMO1 EIF2B2 [activation] CDK4 H1F0 [inhibition] PAFAH1B1 DAB1 [activation] CCR1 STAT1 [activation] IKBKB TNFAIP3 [activation] ADAP2 NCL [activation] PGR KAT2B [activation] EP300 PRKCD [activation] ILK PARVB [activation] SFN KLHDC2 [activation] AK2 GH1 [inhibition] TRIP6 PRKAA2 [activation] FMNL1 TIA1 [activation] GRB2 TESPA1 [activation] HDAC4 AR [activation] RAP1B TP53 [activation] DAPK1 IFI30 [activation] FAM71C DNAJB9 [inhibition] LAMTOR4 RRAGB [activation] LAMTOR5 RRAGD [activation] RAB11A TRAF6 [activation] HCK VAV1 [activation] NOS3 HDAC3 [activation] PTPN12 JAK2 [activation] BARD1 CCDC136 [activation] ACAP1 ABL1 [activation] PIK3R3 LUC7L2 [activation] GOSR1 PKP1 [activation] SLC7A6 ESR2 [activation] 页 125 共 454


2016/4/8 19:14

IGF2BP1 AURKA [activation] XRCC1 FYN [activation] ERBB2IP SMAD4 [inhibition] CTNNBIP1 NACAP1 [inhibition] PCNA DDX11 [activation] PIAS1 MYB [activation] GSK3A GSKIP [activation;inhibition] CASP8 IKBKG [activation] PTPRF BCAR1 [inhibition] NR3C1 NCOA4 [activation] LONRF1 NR4A1 [inhibition] SMAD4 MSANTD3 [activation] JUN SUMO4 [activation] RNF38 UBE2H [activation] MDM2 IRF1 [activation] MAPK8 FAS [activation] EIF4A3 RPS24 [activation] ERBB4 TAB2 [activation] YAP1 IQGAP1 [inhibition] NUDC MAP3K3 [activation] GHRHR GHRL [activation] MAPKAPK5 EIF4E [activation] CDK1 MLKL [activation] SUMO2 NBN [activation] BAD GIMAP5 [activation] ABCF3 SPP1 [activation] MDM2 HSPE1 [activation] PPP2R2B PTK2B [activation] PDIA4 EIF2B1 [activation] ETS2 STAT5B [activation] FYN ENO1 [activation] COL1A2 APP [activation] NUP62 LRRK2 [activation] SMAD2 EIF5B [activation] PRKCI GAPDH [activation] VASP XIRP1 [activation] GSK3B PXN [activation] CDKN1A NGFR [activation;inhibition] APC ASAP1 [inhibition] NXF1 SMARCC1 [activation] NOTCH2 ANKRD28 [activation] P2RY1 SLC9A3R1 [activation] RPS19 VCAM1 [activation] CACNB1 CACNA1C [activation] CACNA1A BTG3 [inhibition] UBA5 ATG101 [activation] ARHGAP32 GRB2 [activation] PIN1 TRAF2 [activation] STX5 YKT6 [activation] SMAD2 PPARG [activation] ITGA6 ADAM9 [activation] ARF6 ARRB1 [activation] ANGPT2 LYN [activation] ARF1 TMED10 [activation] DCLK3 CDK5 [activation] ADPRH SRPK1 [activation] KRTAP10-3 XCL1 [activation] NOS2 CALM1 [activation] ELMO1 RHOG [activation] TRPV4 HCK [activation] HIST2H3A AURKB [activation] FKBP8 CAMK2A [activation] PTK6 KHDRBS1 [activation] TRAF6 CD81 [activation] STK16 MIIP [activation] MCM5 EP300 [activation] NKTR MAPK14 [activation] GEM CCDC102B [activation] HNRNPA0 ESR1 [activation] HIF1A SHC1 [activation] ACTG1 SUMO3 [activation] SPRED2 KIT [activation] BMPR2 CES1 [activation] POLR2A TRAK1 [activation] PRKAA1 PPP2CA [inhibition] SOS1 ITSN2 [activation] 页 126 共 454


2016/4/8 19:14

HLA-B ARHGEF4 [activation] YWHAZ CDKN1B [activation;inhibition] SUMO1 PRKDC [activation] PDGFRL PPP3R2 [activation;inhibition] GTF2A1 BCL3 [activation] SRC STAP2 [activation] PTPRC JAK2 [activation] CAPN1 FANCG [activation] PLCB1 PARD6A [activation] MET LCK [activation;inhibition] RPS24 MDM2 [activation] RPS6KA1 CARHSP1 [activation] JAG1 THBS1 [activation] LAMTOR2 RPTOR [activation] NR1H3 PPARA [activation] WDR92 PARD6A [activation] ATF4 NFE2 [activation] TBP FOS [activation] PRDX2 MAST1 [activation] MAPK3 UBTF [activation] EP300 USF2 [activation] WAS EGFR [activation] IL1R1 PDGFRB [activation] TNFSF11 SRC [activation] RPA1 SMC2 [activation] APC NANS [inhibition] PAK1 ZBTB18 [activation] PPP2R1A GABARAP [activation] EP300 CEBPD [activation] PRKCZ PRG2 [activation] MDM2 CDKN1A [activation;inhibition] CDKN1A QARS [activation;inhibition] MAP3K7 SMAD3 [activation] DVL1P1 APC [inhibition] CAB39L MLH1 [activation] TP53 DBN1 [activation] VCAM1 RAP1B [activation] CREBBP HNF1A [activation] BARD1 TMEM248 [activation] SKI SIX1 [activation] AKT1 SIRT1 [activation] PRMT5 LUC7L [activation] TH RPS6KA5 [activation] PDIA3 STIM1 [activation] DCN INSR [activation] RECQL5 PLK1 [activation] AZI1 LATS1 [inhibition] APC DLGAP1 [inhibition] ICAM1 ACTB [activation] RPA1 RAB5C [activation] JUNB EP300 [activation] OTX2 LHX1 [activation] GSK3A PRKDC [activation] RTN2 FANCG [activation] RPA2 RPA1 [activation] RELA ABCA1 [activation] CDC25A FGF21 [activation] BET1L GOSR1 [activation] UBE2H RNF4 [activation] WNK1 PFKP [activation] STK38 HSP90AA1 [activation] RFX1 NOTCH1 [activation] COL4A4 OSM [activation] NR3C1 AKT1 [activation] CRK NXPH3 [activation] RBL1 LAMB2 [activation;inhibition] PRKCI GBAS [activation] GRB2 SHB [activation] LRRFIP2 MYD88 [activation;inhibition] ACP5 PPP2CB [activation] CBLB BTK [activation] GNAQ RIC8A [activation] C15orf57 HSPB1 [activation] EGR2 ACP5 [activation] GRB2 MYH11 [activation] RALA EXOC3 [activation] 页 127 共 454


IL1RAP TICAM2 MAP3K2 MAP3K3 CCND1 FBXO31 CEBPB HDAC1 KLK6 COL4A6 E2F1 CDK7 DERL2 SEL1L GNAS ADORA1 NCOR1 NFE2L2 SRC KIT GNAL BABAM1 RAP1B APP SATB2 PIAS1 SLC25A6 GABARAP PPM1B VHL IQGAP1 PIK3R2 LIFR CNTFR ACTR2 SNW1 GAB1 VAV2 STK4 MOB4 CDC5L CNOT10 GABARAPL1 SRPK1 SEC23B KCNE4 KCNA1 IL1B A2M PRKAA1 PRKAG2 CDC5L ETS1 MMP2 CCL7 WASL CTTN STRAP EGFR PRKCQ CASP3 TRAF2 PKN1 ITGB1BP1 SKP2 IFI27 LZTR1 HCLS1 CALM1 MAP3K8 MYB FBXW7 MAPKAPK2 RFX6 ARNT2 GRB2 SPRYD4 TDRD7 CCND1 ANKRD54 BLK PPARG ZNHIT3 PTPRC PKP4 CD93 C1QA CCT8 MAPK8 SKIL MORC4 NAIP MAP3K7 ENO2 SUMO1 TRAF6 APP C20orf112 NOTCH1 ANAPC1 TP73 DAB2IP LRRK1 VGF CEP350 PPP2CA RGS14 NFKB1 CTSC CST7 ARHGAP26 YWHAQ MYL3 PRKAA1 MARK3 CDC42BPG PKM POLE2 GAB1 PTPRC SMAD4 RAC2 EPAS1 PRKD1 YWHAZ TAB2 SERPINB3 SNCA MAPT CHEK1 CLSPN LMF1 LIPC BTK HCK SRGAP3 WASF1 HMGB1 HOXB3 ARFGAP1 APOE YWHAE KPNB1 TLR3 CD14

2016/4/8 19:14

[activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] OPRK1 [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] ITGB1 [activation] [inhibition] [activation] [activation] [activation] UBE2J1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] SRPK1 [activation] [activation] [activation] [activation] [inhibition] [activation;inhibition] [inhibition] SRPK1 [activation] [inhibition] [inhibition] RHOQ [activation] [activation] [activation] [activation] [activation] [activation] MAPK8 [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 128 共 454


2016/4/8 19:14

RBBP8 BARD1 [activation] NOS1 RASD1 [activation] EXOC5 C9orf9 [inhibition] ADAMTSL4 RHOJ [activation] MLH1 RAD50 [activation] GIT1 PAK2 [activation] NPAS2 KAT2B [activation] GRB2 KHDRBS1 [activation] SHC1 MAPKAPK2 [activation] RYR2 CFTR [activation] PDGFB COL2A1 [activation] NTF4 BDNF [activation] MASP2 SERPING1 [inhibition] FCRL2 NCK2 [activation] TNF SPOCK1 [activation] CCT8 ILK [activation] PIK3R4 PIK3C3 [activation] MED24 TNFSF11 [activation] ASCC2 PIK3CD [activation] CASP8AP2 PIAS1 [inhibition] GNB2L1 SLC25A6 [activation] RPS6KB1 XPO1 [activation] SUMO2 NFE2L2 [activation] SRGAP2 FMNL1 [activation] SUV39H1 FYN [activation] RALA CTCF [activation] PAXIP1 ECSIT [activation] PSEN2 CASP8 [activation] PRDX2 VCAM1 [activation] APP TRPT1 [activation] RGS20 LCE2D [activation;inhibition] CDH2 UBC [activation] ESR1 HYOU1 [activation] MET HGFAC [activation;inhibition] ILF2 RAD50 [activation] CAPN1 DES [activation] ACTB RPA1 [activation] EGFR CHD5 [activation] EEF1A2 PTEN [activation;inhibition] PMS2 SFRP4 [activation] BCR PIK3R2 [activation] SIRT1 MCF2L2 [activation] SMAD1 KMT2D [activation] HERPUD1 CD3D [activation] FABP3 NUP62 [activation] SUV39H1 GPATCH2L [activation] BMP1 TP53 [activation] SMEK1 LRRK2 [activation] ORC4 CCND1 [activation] COMT RGS2 [activation] ITGA4 LPXN [activation] SORBS1 MAP4K3 [activation] HDAC3 SRF [activation] CASP6 MAPT [activation] TBC1D5 ULK1 [inhibition] ADORA1 ADORA2A [activation] F2RL2 GRB2 [activation] FAM118B RASGRP2 [activation] HSP90AB1 EPHB1 [activation] TRAF3 TNFRSF9 [activation] GDF5 ACVR2B [activation] DAAM1 SRC [activation] GRN SGTA [activation] GAB2 MARK2 [activation] GRB2 SKAP1 [activation] NCOA3 BMP7 [activation] HSPA4L HLA-B [activation] TBK1 IKBKB [activation] TRAF6 UBE2D4 [activation] MAP3K4 MAP2K1 [activation] HLA-B SSR1 [activation] CEP250 NUP62 [activation] IER3 PRNP [activation] RAN MAD2L2 [activation] GRB2 MSI2 [activation] SCYL3 EZR [activation] 页 129 共 454


2016/4/8 19:14

RICTOR ILK [activation] CD1D B2M [activation] ITGA5 ERBB2 [activation] EIF2AK2 HSP90AB1 [activation] CD9 CD81 [activation] TGFBR2 CDC42 [activation] CD247 SIK1 [activation] UBE2B NBN [activation] XIAP RAC2 [activation] FBXO18 HSP90AB1 [activation] SNAI1 PALB2 [activation] NR3C1 NFKB1 [activation] SFN RAE1 [activation] ANXA5 HUWE1 [activation] DLG2 NOS1 [activation] SUPT4H1 ANXA5 [activation] DBNDD2 CSNK1D [activation] SETD8 FAM9A [activation] PICALM PELI2 [activation] RPS6KA5 MBP [activation] TRAF1 GIT2 [activation] ERAP1 IL6R [activation] MAPK9 HDAC1 [activation] TNFRSF9 LRR1 [activation] XRCC1 RPA3 [activation] PAXIP1 ATHL1 [activation] CDC20 ANAPC11 [inhibition] MAPKAP1 MLST8 [activation] RARA CDK7 [activation] ULK1 ATG13 [inhibition] MSL2 TP53 [activation] HSP90AB1 TSSK6 [activation] MAPK1 RXRA [inhibition] BCAP31 CASP3 [activation] PROSER2 STK24 [activation] SHB PDGFRA [activation] RPS6KB1 POLDIP3 [activation] MAPK3 MBP [activation;inhibition] HSPB1 RAB43 [activation] HSPA4 RICTOR [activation] PDCD6IP PLXNA2 [activation] MAPRE1 TRAF6 [activation] RAD52 RPS19 [activation] SGOL2 PPP2R5A [activation] MAP2K6 SMAD7 [activation] HSP90B1 TLR4 [activation] DIABLO CDC40 [activation] STX2 VAPB [activation] S1PR5 GNA12 [activation] LTK TNK2 [activation] DRD5 GABRG2 [activation] WNK1 CSDE1 [activation] CASP9 PRKCZ [activation] LILRB1 B2M [activation] INADL PARD6A [activation] CFL1 MAPK6 [activation;inhibition] MAPK8 PRKDC [activation] RXRB TACC2 [inhibition] FBXO18 RPA3 [activation] JUN SUMO1 [activation] BCAR1 PTK2B [activation] EXT2 EXT1 [activation] ESR1 PIAS2 [activation] SKIV2L2 VCAM1 [activation] HOXB1 EP300 [activation] RASIP1 RRAS [activation] HSPA8 IKBKE [inhibition] CASP10 CASP8AP2 [activation] ICT1 HSPA9 [activation] UGT1A1 B3GALT1 [activation] RCHY1 CAMK2A [activation;inhibition] NCK2 MET [activation] HLA-B PTGES3 [activation] ELAVL1 ATM [activation] BAX UVRAG [activation] SYK AR [activation] 页 130 共 454


2016/4/8 19:14

MYC DOCK7 [activation] LIN37 MYLPF [activation] SMAD4 USP9X [activation] PTPLAD1 LRRK2 [activation] NXF1 SHC1 [activation] PSMC3IP FGFR4 [activation] CXorf22 ESR1 [activation] CHRDL2 BMP7 [activation] H2AFX EIF2S2 [activation] YWHAG MAP3K3 [activation] PTGER2 ARRB2 [activation] MECOM JUN [activation] LRRK2 MKI67 [activation] NPRL2 ANXA7 [activation] ATG5 ATG13 [activation] MAPK13 MAPT [activation] SMAD7 MYOD1 [activation] SIX1 FZR1 [activation] RCC1 NGFR [activation] STX7 GTF2I [activation] STMN1 VCAM1 [activation] MC4R ATRNL1 [activation] VTA1 TRAF6 [activation] STX11 SNAP23 [activation] IGF1R KLK5 [activation] NTRK3 RASGRF1 [activation] ZIC1 GLI1 [inhibition] GK AOX1 [activation] NGF PLG [activation] HOXB3 CREBBP [activation] NOTCH1 CAMK4 [activation] CCL5 SDC1 [activation] EP300 DECR2 [activation] CAMK2B ITPKA [activation] ZAP70 IFNAR1 [activation] NUDC TP53BP1 [activation] NOTCH1 WDR12 [activation] PGM1 ENO3 [activation] IL2RA IL2RB [activation] EGFR RAF1 [activation] MYOD1 SP1 [activation] KPNB1 EEA1 [activation] CYP17A1 STK11 [activation] PTK2 DEF6 [activation] NIPSNAP1 MDM2 [activation] CDC42 DOCK8 [activation] CAND1 SRPK3 [activation] CD93 MYD88 [activation] RAD50 SKP2 [activation] ARRB2 IGF1R [activation] BCL3 CTBP1 [activation] YWHAZ CTNNB1 [activation] CREM CAMK2G [inhibition] LCE3E NOTCH2NL [activation] EHMT1 BMI1 [activation] STAT3 EZH2 [activation] ESR1 IRS1 [activation] MYC AHNAK2 [activation] YAE1D1 TPD52L1 [activation;inhibition] APP APBB1 [activation] LRP1 MMP15 [activation] OBSL1 TBL3 [activation;inhibition] ZFP36 CCL3 [activation] ITGA4 EIF4A1 [activation] EGFR CAV3 [activation] LYN CD24 [activation] PIGR MIS12 [activation] MAPK1 NAV1 [activation] E2F3 FHL2 [inhibition] PPP2R1B EGFR [activation] SHC1 PTPN12 [activation] SRPK2 BARD1 [activation] CHEK2 CDC25A [activation] ANXA5 TINF2 [activation] SEMA6A SORBS2 [activation] FOXO1 AR [activation] 页 131 共 454


2016/4/8 19:14

POLR1D CRKL [activation] STX7 VPS16 [activation] SHC1 GRB7 [activation] CD97 SRC [activation] RB1 PAX8 [activation] RYR1 PPP2CA [activation] PRMT5 SNAI1 [activation] NCK1 EPHB2 [activation] BTK PIP5K1B [activation] HSPA1L CDC20 [inhibition] SMAD1 LEF1 [activation] NCK1 F2RL2 [activation] STK11 CRY2 [activation] ETS1 ZFR [activation] RNF181 ITGA2B [activation] METTL22 HSPA8 [inhibition] PRKAA2 AGL [inhibition] GC GRB2 [activation] CDC42 RAC1 [activation] YAP1 SCAMP3 [inhibition] SRSF1 NFYA [activation] GRB2 TUBB [activation] SHC1 TIMM50 [activation] EGFR MAPK14 [activation] UNC93B1 TLR9 [activation] EIF3K ICAM1 [activation] ABCA1 LIN7C [activation] FZR1 ANAPC4 [activation] MDM2 ESR1 [activation] TGFB1I1 SVIL [activation] PLCG1 RIN3 [activation] MANBAL CACNA1A [inhibition] BID CRMP1 [activation] CCDC53 ABI2 [activation] EPM2A PRKAA1 [inhibition] CMPK1 BACE1 [activation] PYHIN1 MDC1 [activation] TBX21 GATA3 [inhibition] KMT2A MLLT4 [activation] CDKN2A HIF1A [inhibition] AURKB FTH1 [activation] COPS3 CTNNB1 [activation] MAGED1 ILK [activation] IKBKB MAP3K11 [activation] HERPUD1 PSEN1 [activation] NMI STAT4 [activation] HSPH1 PAFAH1B3 [activation] STK11 RPS6KA5 [activation] HNRNPA2B1 MAP4K2 [activation] CCK CCKAR [activation] ACTB HSPA8 [activation] HSP90AB1 KBTBD4 [activation] STX4 STX8 [activation] EIF1B RHOB [activation] TP53 NR3C1 [activation] YWHAZ WNK4 [activation] ATG5 NEDD8 [activation] SRC FANCA [activation] MYC TPP1 [activation] CDC5L STAT3 [activation] YARS ITGA4 [activation] FKBP3 TP53 [activation] PSMC3IP RXRA [inhibition] CTNND1 CDH3 [activation] CD79B CD5 [activation] PIAS1 PIAS4 [inhibition] RAC1 LRRK2 [activation] CSNK2A1 DVL3 [activation] SLC24A1 GRB2 [activation] RELA IL1RN [inhibition] APP IFNA16 [activation] RIPK1 RPL23 [activation] BCAP31 RPA2 [activation] PSMC3IP CHEK2 [activation] NOXA1 CACNA1A [activation] HSPA6 TAB1 [inhibition] 页 132 共 454


IFNAR1 LRRK2 RHOBTB2 CSNK2B CDKN1A SMARCB1 GABARAP PRKACA CLSPN CSNK2B ESR2 MYL12A SUMO1 NR4A1 TNF JAK1 ALK PRKAA1 IL37 SETD4 STAM E2F1 ADRB2 PLEKHA8 SKAP2 PPP1R2 YWHAG ZAP70 MPG SFN MAPK1 HSPA14 TPD52L1 RERE GNB2L1 MEIS1 RASSF9 RANBP2 QKI SMAD2 CDH2 PRKCH SRPK1 INADL AR STX4 MAGI1 PFKFB2 SMARCC1 PRKCA INSIG2 DNAJB1 MTOR RXRG H2AFX PRR20C HLA-B ARRB2 EGFR ACTB WNT6 CDK1 STAT6 CCDC8 BTRC AGTRAP FMOD RPA1 INSIG1 GCN1L1 SRSF10 NBN HMMR IQCB1 NOP16 HIST3H3

2016/4/8 19:14

PIK3R1 [activation] ZRANB2 [activation] RHOBTB3 [activation] MAPK14 [activation] SETDB1 [activation] SMARCA2 [activation] FASN [activation] AKAP13 [activation] PRIMPOL [activation] PAXIP1 [activation] MCM2 [activation] PAXIP1 [activation] OBSCN [activation] STAT3 [inhibition] PTPRZ1 [activation] IRS2 [activation] PIK3R1 [activation] PNMA5 [inhibition] CASP4 [activation] NXF1 [activation] YWHAB [activation] BTRC [activation] GPRC5B [activation] ARF1 [activation] FASLG [inhibition] GSK3A [activation;inhibition] MCM5 [activation] APP [activation] PRNP [activation] BCR [activation] RGS19 [activation;inhibition] PAXIP1 [activation] SFN [activation] EHMT2 [activation] AURKB [activation] CREB1 [activation] DVL2 [activation] RANGAP1 [activation] VCAM1 [activation] PIAS4 [inhibition] PTPRK [activation] BANP [activation] KCNN2 [activation] KCNJ15 [activation] IL6ST [activation] RAB11A [activation] RASA1 [activation] YWHAZ [activation] TP53 [activation] ANXA7 [activation] PSMD4 [activation] ATG2A [inhibition] PREX1 [activation] PPARG [activation] SLC25A6 [activation] FAM168A [activation] FUS [activation] FZD4 [activation] AAMP [activation] MYOC [activation] PORCN [activation] ITGA4 [activation] NCOA1 [activation] CACNA2D1 [inhibition] CD4 [activation] HMGB1 [activation] TGFB3 [activation] COBL [activation] ELAVL1 [activation] OBSL1 [activation] EZH2 [activation] BARD1 [activation] MAPK3 [activation] GNAI1 [activation;inhibition] SRPK2 [activation] BRD7 [activation] 页 133 共 454


2016/4/8 19:14

CSF2 HNRNPA2B1 [activation] HSP90AB1 PRKCZ [activation] MON1A MAPK6 [activation;inhibition] TRIM62 SKIL [activation] PLCG1 PICALM [activation] GRB10 PDGFRB [activation] MBP ABL1 [activation] MYOD1 SMAD3 [activation] LOXL1 ELN [activation] TRAF6 EIF3I [activation] RICTOR RPTOR [activation] CSNK1E HMMR [activation] PVRL4 TIGIT [activation] RPL35A TRAF6 [activation] IL20RA MLH1 [activation] DDAH2 STK3 [activation] UNC5CL RELA [activation] GOLGA2 LCP2 [activation] PROP1 CNTN1 [activation] DARS ESR1 [activation] CSNK1E LRRK2 [activation] GFAP CAMK2A [activation] MIF TP53 [activation] TRAF2 HSPA4 [activation] SCIMP LYN [activation] CHEK1 USP7 [activation] GADD45A MAPK1 [activation;inhibition] CDH1 MDM2 [activation] BLOC1S6 CDK5R1 [activation] TSC2 PPP2CA [inhibition] HSPE1 CASP3 [activation] SMARCA4 TP53 [activation] PPP2R1A ITGA4 [activation] NCOA2 RARA [activation] LMTK2 CDK5 [activation] COL14A1 CD44 [activation] TP53 STX5 [activation] BCL2L1 BCL2L10 [activation] UEVLD TRAF6 [activation] STX3 SYT1 [activation] LCK CD55 [inhibition] IRS2 YWHAE [activation] BRD7 UBE2I [activation] PRKCB PKN1 [activation] GRB7 FGB [activation] MBP PRMT5 [activation] ANAPC11 UBE2U [activation] L1CAM PRNP [activation] TRAF2 FDXACB1 [activation] SOCS3 AR [inhibition] ITGB1 SEL1L [activation] CDC42 ARRB1 [activation] HTR2A GLUL [activation] EHMT2 ESR1 [activation] UBC BMP6 [activation] CALM1 ARHGEF7 [activation] PASK FGA [activation] HSP90AB1 SKP2 [activation] PPP1R1B ROBO2 [activation] EIF4A1 GABARAPL1 [activation] EIF4A1 PPP2R1A [activation] ACTB EP300 [activation] PTPRJ LYPD3 [activation] TNIP2 SRPK2 [activation] MAP3K8 HSPA1L [inhibition] LUC7L2 SRSF6 [activation] SP1 C3orf17 [activation] PLEKHB2 MAP3K1 [activation] UBE2I STRA13 [activation] GPR135 TPD52L1 [activation] RPS6KA6 SPTBN4 [activation] SIRT3 DNM1L [activation] PLCB3 PRKG1 [inhibition] ATF2 HIST2H2BE [activation] PMS1 REV3L [activation] COPB1 RHOQ [activation] 页 134 共 454


2016/4/8 19:14

EIF2B1 STK11 [activation] PTK2 PXN [activation] YTHDF1 CDKN1A [activation;inhibition] CCDC172 FAM13C [activation] PCBP3 ARF6 [activation] HSPA4 TSSK6 [activation] INCENP AURKB [activation] PPP2R5A BEST1 [activation] LAMB1 ANTXR2 [activation] CCNF NUSAP1 [activation] FLT1 ROBO4 [activation] GCN1L1 ASB5 [activation] SRPK1 CHTOP [activation] PLG KNG1 [activation] TGM3 SLX4 [activation] PVRL2 MLLT4 [activation] TBL3 AURKB [activation] VCAM1 ARPC3 [activation] H3F3A CD81 [activation] ABL1 EP300 [activation] LYN CASP3 [activation] TP53BP1 SPAG9 [inhibition] PRKCQ MAP4K3 [activation] LRP1 RANBP9 [activation] CCT8 STK4 [activation] TNKS RAPGEF2 [activation] TLR2 CREBBP [activation] CDK1 EIF2AK2 [activation] EPHA3 RBM18 [activation] APH1A PSEN2 [activation] KAT2B H2AFX [activation] RPS6KB1 EIF3C [activation] SRPK1 RSRC1 [activation] GFAP SMAD2 [inhibition] IGF2BP1 ITGA4 [activation] ERLIN1 FA2H [activation] RAD50 BRCA1 [activation] SETDB1 ECSIT [activation] ESR2 NCOA3 [activation] ARGLU1 SRPK1 [activation] HSF1 TAF9 [activation] PTPRC GHR [activation] PLCG2 CBLB [activation] HSP90AB1 MUSK [activation] LAMB1 ERBB2IP [inhibition] CSNK1D PML [activation] PCNA FANCA [activation] BDNF SORT1 [activation] RAD51AP2 RAD51 [activation] HSP90AA1 CDK18 [activation] GDI1 RAC2 [activation] ENOX2 ENOX1 [activation] UBE2I WNK2 [activation] QRICH2 SSSCA1 [activation] RAB5A RIN3 [activation] IL6ST STAT1 [activation] MAPK8 CDKN1B [inhibition] P4HB ERO1L [activation] HSP90AB1 TTC4 [activation] TRPC3 ORAI1 [activation] PRKACA NOS1 [activation] CSNK2A1 MYO1B [activation] FANCG FANCB [activation] A2M RNF32 [inhibition] NFKB1 CCAR2 [inhibition] TSC2 FBXW5 [inhibition] NIF3L1 RAD54B [activation] CCDC155 VAMP1 [activation] CCDC67 TXLNA [activation] KIAA0408 ABI1 [activation] USP4 ADORA2A [activation] RAC1 SOD1 [activation] PPP2R1A CCDC43 [inhibition] DNM2 CDK1 [activation] EFS SRC [activation] F11 SERPINF2 [activation] 页 135 共 454


KIAA0319 ELAVL1 NRAS PTCH1 SMURF1 RAB3D MAST1 SH3BP2 DBNL TP53 SMAD2 DAB2IP RIPK1 NUCB2 CASP3 HIST1H2AG FYN TCAP TNFRSF1B GTPBP1 RAD21 WASF1 PFN1 ACTN1 CAMK2A NGFR H2AFX BRCA1 MYC CEP63 CAMKK2 STK4 PAK3 CAPNS1 RASA1 LUZP1 GRB2 CTSB IRS4 BLM MX1 WHSC1 MDM2 RPL23 GRB2 CDK2 PCED1A DOK2 ABL1 RPS6KA3 BARX1 MAX FBXW11 MST1R PLCG1 ABL1 PRKCD RAN RANBP9 EP300 CCNB1 TRH ARRB2 BMI1 SRPK2 SH3GL2 LRRK2 PPP1R12A ATF2 PML CDCA3 CTDSP1 SRPK2 ABL1 NCAPG2 MYC MRPL24 TP53 PPP2R1A PMS1 STAG2 RAD21 S100B MAPT SRF ALDH3A1 CCDC8 CDC23 MDM2 BUB1B PPP2R1A PPP2R5E PPP1R12A ASNS DDA1 NPRL2 CDKN1A ATG12 EPB41L5 IDE NR3C1 FCGR2A BLK PGF NRP2 KIAA1598 SMARCA4 RUNX1 HRAS ICMT MYC BCR HSPA8 RIPK2 GEM KRT40 PRKCD SPI1 MAPKAPK3 MKNK2 LRRK2 ELN EFEMP2 PDZD3 CACNA1S SRPK1 ALYREF RUNX1T1 RBPJ CALM1 FAS TMOD3 DAPK1 HOXD11 MEIS1 SORBS2 PTK2B TAF1 HSF1 IRF1 ULK2 LILRB2 HLA-A GDF2 ACVR2B

2016/4/8 19:14

SH2B1 [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] MME [activation] [inhibition] BMX [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] SETD7 [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] LATS1 [inhibition] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] NME7 [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] STK11 [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 136 共 454


2016/4/8 19:14

YWHAE KIF23 [activation] SRC DDX58 [activation] AIMP1 MAPK14 [activation] CRYAA BCL2L1 [activation] DCLK2 HSP90AB1 [activation] ATM PARP1 [activation] RRM1 ATG5 [activation] ATRX LUC7L2 [activation] RAC3 AR [activation] DAZAP2 TCF7L1 [activation] OAZ1 EGFR [activation] CTNNB1 NOS3 [activation] PAK6 MDM2 [activation] CARD17 CARD18 [inhibition] RBBP9 RB1 [activation;inhibition] BTK FCER1G [activation] ACTG1 IKBKB [activation] CFTR PRKDC [activation] TRPV4 YES1 [activation] PRKCE GRM5 [activation] TTF2 MYB [activation] ABI3 ACTN3 [activation] LYN MET [activation;inhibition] IGHA1 LRRK2 [activation] RAD21 SKIV2L2 [activation] FAM98B BCKDK [activation] ISL1 SMAD3 [activation] SAMHD1 LRRK2 [activation] MAPK1 MTPN [activation] SRC DLGAP3 [activation] CDK3 KIR3DL1 [activation] YWHAZ VASP [activation] JAK3 STAM [activation] RPA3 HNRNPCL1 [activation] DNPH1 FTSJ1 [activation] JUND AR [activation] TTC3 NR3C1 [activation] CRK PRX [activation] NFYA JUN [activation] APP CGB [activation] CDC27 GRB2 [activation] HSP90AB1 CSNK1E [activation] BIRC3 SPHK1 [activation] CCDC138 SAV1 [activation] PAK4 FGFR2 [activation] GABARAP GNL3 [activation] CTCF AIM2 [activation] PRPF31 JAKMIP2 [activation] PARD6B TCP10 [activation] TGM1 ALOX12B [activation] MCM10 CDK6 [activation] BCL6B BCL6 [activation] PRKD2 PSG3 [activation] MAPT PEG10 [activation] IK NUP62 [activation] TRAF2 EGFR [activation] RAPGEF3 NUP98 [activation] PCDHA6 CRK [activation] IGHG2 GABARAPL1 [activation] TNFSF11 ADAM19 [activation] ACAP2 HSPB1 [activation] STX7 SYNPO2 [activation] RIT2 SRPK2 [activation] CHGB LRRK2 [activation] RASSF1 IGFBP5 [inhibition] MEOX2 RELA [activation] IGF1R SOCS1 [inhibition] TOLLIP CAV1 [activation] GRB2 VPS13A [activation] DUSP3 BNIP3L [inhibition] ANKRD17 ITGA4 [activation] HIST3H3 RPS6KA5 [activation] TNIK CYCS [activation] PPP2R1A MCC [inhibition] NR3C1 MAPK15 [activation;inhibition] MDM4 CASP3 [activation] 页 137 共 454


2016/4/8 19:14

SMAD4 PBK [activation] PPP1CC SFRP1 [inhibition] MARCKS TRAF6 [activation] NUDCD3 KLHL33 [activation] AR GRAP2 [activation] CALM1 GLP1R [activation] RAB21 ITGB1 [activation] PPIA VCAM1 [activation] GABARAPL2 HSPH1 [activation] SRC ANXA1 [activation] PRKCI YWHAH [activation] CTNNB1 PTN [activation] REXO2 TRAF6 [activation] PRKCA PRKG1 [activation] NUP62 CTNNB1 [activation] MAPK1 MAPK3 [activation;inhibition] TXNRD1 CAV1 [activation] CDC42EP4 SRPK2 [activation] PIK3R1 ADAMTS2 [activation] ADAM19 ABI2 [activation] YWHAG RSRC1 [activation] ISL1 PECR [activation] AXIN1 DAB2 [activation] ATF2 ZDHHC17 [activation] SRPK1 FOS [activation] CDH1 CASP8 [activation] CFTR RAB5A [activation] HABP4 PPP1R15A [inhibition] PRKAB1 GRB2 [activation] AKR7A2 ITGA4 [activation] ILK SERPINA4 [activation] A2M DNAJB1 [inhibition] BTK MYD88 [activation] CHUK CDC37 [activation] PIK3CG IL6ST [activation] KCTD5 ILK [activation] NCAPG SMC2 [activation] PFN1 ASB2 [activation] KIAA1279 DOK2 [activation] FILIP1 HSF1 [activation] CCR3 HCK [activation] F2 SERPINB8 [inhibition] JUN NFATC2 [activation] BCAS3 CCND1 [activation] PLSCR1 EGFR [activation] RPAP3 HSP90AB1 [activation] CYFIP1 GNB1 [inhibition] SUV39H1 STX11 [activation] NLK RNF219 [inhibition] HSPA6 ESR2 [activation] BMX HDAC1 [activation] WDR48 DKC1 [activation] IRF9 IFNA1 [activation] FUS GRB2 [activation] MLST8 NXF1 [activation] RBX1 CCND2 [inhibition] NOTCH1 RANBP10 [activation] HSPA1A ST13 [inhibition] MSR1 LEPROTL1 [activation] BDNF F11R [activation] BCL3 GSK3A [activation] MDM2 EZR [activation] ARMC8 NOTCH1 [activation] TMEM62 PTPN6 [activation;inhibition] PAPPA IGHG1 [activation] DPH2 IL17A [activation] TGFBR1 PPP6C [inhibition] CXCR4 CTSG [activation] GABARAPL2 STK3 [activation] PSEN1 CTNND1 [activation] PLLP MMP14 [activation] TGFB3 TGFBR1 [activation] STMN1 PINX1 [activation] NR2E3 PPARG [inhibition] TBC1D23 C12orf45 [inhibition] ESR2 GAL3ST4 [activation] 页 138 共 454


2016/4/8 19:14

MYOD1 HDAC1 [activation] GRB2 RAB1C [activation] SMURF1 WFS1 [inhibition] STX17 SNAP29 [activation] WNK4 CLDN2 [activation] FRK ABI1 [activation] ARF6 HNRNPM [activation] RPA1 ARRB2 [activation] GDF9 PCDHA4 [activation] NFE2 SCAND1 [activation] TDP2 ETS1 [activation] TP53BP1 BLM [activation] CDK2 MCM4 [activation] FCGRT ATG16L1 [activation] LCK PTPRK [inhibition] TP53 ACTA2 [activation] ERBB2 GRB7 [activation] CASP9 BIRC6 [inhibition] ANXA1 DAB2 [activation] NFASC CRK [activation] ILK TRAFD1 [activation] DNPH1 PILRA [activation] TNFRSF10B IGHG1 [activation] PRKAA1 TOMM34 [inhibition] ANGPTL4 CDKN2A [inhibition] ITGA4 STOM [activation] PVRL4 PVRL2 [activation] MYC PADI2 [activation] CTTN RPA1 [activation] LCP2 PAG1 [activation] SMAD3 AXIN2 [inhibition] SETD7 STAT3 [activation] MAPK3 STMN1 [activation] SNCA CYCS [activation] GRB2 GRWD1 [activation] MCM3 HIST1H4A [activation] CDK4 NCOA2 [activation] RAN ELAVL1 [activation] EDRF1 BCL2L1 [activation] CCL21 LRRK2 [activation] YWHAZ RBL1 [activation;inhibition] RPTOR RAB1A [activation] HLA-B CAPRIN1 [activation] EP300 RBBP5 [activation] SMARCC1 SRC [activation] SUMO1 GNAL [activation] WDR92 RPAP3 [activation] GDI2 ATG5 [activation] PPP2R3A PPP2CA [inhibition] RAE1 NUP62 [activation] LRRK2 SLC25A4 [activation] PPP1R14A PRKCZ [activation] RARA ARNTL [activation] GRB2 HIPK3 [activation] A2M PRDX2 [inhibition] HTR2A GRM2 [activation] TNF NEFL [activation] CHD4 SMARCA4 [activation] HNRNPA1 YWHAZ [activation] PRMT5 JAK2 [activation] ANAPC15 ANAPC4 [activation] DARC CCL2 [activation] KCNIP1 KCND2 [activation] PTPN6 IFNAR1 [activation;inhibition] SLC12A2 MDM2 [activation] DNAJC6 CLTC [inhibition] TAB1 RBX1 [inhibition] STAT5A ESR2 [activation] CASP8 OTUD7B [inhibition] DKK3 APC [inhibition] MKNK1 MBP [activation] DUSP13 TGFBR1 [inhibition] SYT13 NRXN1 [activation] FTSJ3 OBSL1 [activation] EIF3G ICAM1 [activation] DYSF ANKRD1 [activation] 页 139 共 454


MAP1LC3B EYA1 GNAI2 SMAD9 DSTN ITGB1BP2 ICAM5 PSEN2 REEP3 SFN LAT ITK CAMKK2 PRKACA AGTRAP DDX55 LYN LCP2 PPP2R1A STRN3 HSPB1 GOLGA8A AKT1 TLR2 TICAM1 TICAM2 PPP2CA STRN3 CTSG CASP7 TFEB MITF VAV2 SMAD3 HRAS STK11 PPP1CA HYDIN TP73 NFYB PPP2R1A RORC PPP2R5B PPP2CA PAX7 CRK HLA-B HPRT1 NXF1 UBAP1 CLOCK SOX2 TNFRSF1A PAXIP1 STRAP RBX1 HSPB1 SRC SKAP2 ADRB2 CAPNS1 SPSB1 RASA1 WAS RAC2 SMURF1 MDM2 GSTM4 TP53 KIAA0087 KRAS FANCC GLRX CASP3 MYB SKP2 MAPKAPK2 PAXIP1 SPATA18 HTT DOCK11 MMP2 TIMP4 NOS3 NMT1 IRS2 SIRT1 APC PPP3R2 METTL16 APP EHD1 EGFR IGFBP7 INS HSPB1 AGAP4 CREB1 SMARCA4 PCSK6 CACNA1A RAN EED JAG2 CACNA1A ATXN10 ABCA1 PLG APOH AKAP2 CCDC8 ANAPC15 CDC16 SIPA1L2 YWHAB PRR20E FAM168A CEBPG ATF4 FGB CSNK2B SLC9A3R2 EIF2AK3 HSP90B1 INSR KRT27 ATXN10 EGFR MTOR LAMTOR1 MTA3 NOTCH2 BRCA1 JAK2 DAB2 DVL3 MET SH2B2 RAB11A IKBKE NOS3 BDNF MAPK3 VDR TGFBR2 MAP2K1

2016/4/8 19:14

CTNNB1 [activation] [activation] [activation;inhibition] PIP5K1A [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] HRG [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] TP53 [activation] [activation] [activation] [activation] MAP2K6 [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] SGK1 [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 140 共 454


2016/4/8 19:14

GRB2 PRICKLE3 [activation] CRK SUV39H2 [activation] RRAD CAMK2G [activation] ITSN2 STX4 [activation] USP9X RICTOR [activation] NUAK1 PRKAA1 [inhibition] LIMS1 PLCE1 [activation] PPP2R1A GNA12 [activation] NR0B2 TRAF6 [activation] PPP2R5A DAPK1 [activation] ACTB RCC1 [activation] PCBP2 MDM2 [activation] ITGA4 CD81 [activation] HSPB8 HSPB1 [activation] EPSTI1 BCAR3 [activation] MAP3K8 PIN1 [activation] NR2E3 NR3C1 [activation] GRB2 ASAP1 [activation] TRAF2 SPECC1 [activation] HSP90AA1 KCNS3 [activation] PPP1CC CDKN2A [inhibition] CDK11A C18orf25 [activation] EPHA3 CALM1 [activation] SRC WAS [activation] LRRK2 RPS8 [activation] GTF2E1 GTF2A2 [activation] ATF4 GABBR1 [activation] DDX5 WHSC1 [activation] STX3 STXBP2 [activation] SAV1 PIBF1 [activation] CPVL CDKN1A [activation;inhibition] SRPK1 KIAA1841 [activation] CYCS TRAF6 [activation] PLCG1 SUV39H2 [activation] CAMKK2 IQGAP2 [activation] PIK3R1 GAB2 [activation] TP53 IKBKB [activation] VDAC3 DDX24 [activation] DNM1L GSK3B [activation] RPA1 KIAA1033 [activation] CDH1 ITGB7 [activation] ANAPC4 RAD21 [activation] RFX6 LMO3 [activation] RPL11 STAT3 [activation] BCAR1 PPP1R15A [inhibition] EIF4A1 RAD21 [activation] FAM90A1 GNPTAB [activation] ZFP91 FOS [activation] TAF1B NAPB [activation] CBL CDC42 [activation] OBSL1 KCNE4 [activation] CASP9 CAPN2 [activation] KAT2A CTNNB1 [activation] BIRC2 RIPK4 [activation] PPP1CC PHACTR4 [inhibition] MLLT4 EPHA7 [activation] RIPK1 CDC37 [activation] PRKG1 RGS2 [activation;inhibition] IRF5 GRB2 [activation] YWHAZ CDC25B [activation] HDAC2 GATA4 [activation] PRLR STAT5B [activation] RSPO1 LGR4 [activation] MYC CLSTN1 [activation] HOXD8 HMGB1 [inhibition] ITGA4 HNRNPAB [activation] ESR1 GNL3 [activation] TRAF5 EIF2AK2 [activation] PRKDC TNFRSF1B [activation] CYP11B1 CYP11B2 [activation] PPP2R1A RBM7 [inhibition] APP IFIH1 [activation] RPS6 VCAM1 [activation] BUB1 RASA1 [activation] MTNR1A GNB1 [activation] CAMK2A CHMP5 [activation] 页 141 共 454


2016/4/8 19:14

IKBKE NFKBIA [inhibition] PPARA NCOR1 [inhibition] CAMK2D GRB2 [activation] NRAS ARHGAP4 [activation] CRTAM CADM1 [activation] HSPB1 SMARCA2 [activation] RCC2 TRAF6 [activation] MAPK3 HDAC4 [activation] SGK1 MYH1 [activation] F2RL1 CAPN1 [activation] TGFBR1 LIMS1 [activation] PTPN13 RAPGEF2 [activation] PYCARD AZI1 [inhibition] ITGA4 PDCD10 [activation] CEBPB RPS6KA1 [activation] PRKCE ITGB2 [activation] AP2S1 POLQ [activation] STK3 FBXW11 [activation] PPP1CA ULK1 [inhibition] NUMA1 CDK6 [inhibition] APP MAD2L1 [inhibition] AXIN1 JUP [activation] WWOX SRPK1 [activation] HSPH1 YAP1 [activation] EIF3A EIF4A2 [activation] ITGA4 XPO1 [activation] LNX2 PDZRN3 [inhibition] ADRBK1 PDC [activation] HIST3H3 CHUK [activation] PPP2CA DAPK1 [inhibition] MPP6 ARHGAP18 [activation] HIST1H4A JMJD4 [activation;inhibition] TGM3 PRKAB1 [activation] YWHAG IGF1R [activation] OBSL1 PCNA [inhibition] IGF1R JAK2 [activation] PRKAA1 SNRK [inhibition] CDC16 NXF1 [activation] MARVELD2 MCM7 [activation] SNRPD1 ICAM1 [activation] HIST1H2BM ICAM1 [activation] NCOA1 RORB [activation] CDK5 PCNA [activation] DVL2 SMURF1 [inhibition] SORBS1 PXN [activation] APMAP ATF2 [activation] SMAD2 RASA1 [activation] HSP90AA1 MARS [activation] CAPN1 ARRB2 [activation] UBE2E1 RELA [activation] RIPK1 TLR3 [activation] NLGN3 PRDX2 [activation] SH2D2A LCK [activation] STAT3 NR3C1 [activation] GNB4 CDK18 [activation] TRAF6 CARD11 [activation] GAPDH ANXA1 [activation] BID RPA1 [activation] GNAT2 SUMO1 [activation] COL4A5 DCN [activation] MAPKBP1 MAPK10 [activation] COG8 GEM [activation] UNC119 NPHP3 [inhibition] SP1 IFI16 [activation] LCK KIR2DL3 [activation] HSPA4 MAPT [activation] IQGAP1 WHSC1 [activation] MCM2 CCND1 [activation] DAB2 DAB2IP [activation] GFAP AURKB [activation] SRPK2 SNIP1 [activation] NCKAP1 GRB2 [activation] MTOR MLST8 [activation] GABARAP TRAP1 [activation] CAV1 MAPK3 [activation] NRF1 CEBPB [activation] 页 142 共 454


2016/4/8 19:14

CTNNB1 PRKCA [activation] BTLA TNFRSF14 [activation] EGFR YWHAZ [activation] CDKN1A PHKG2 [activation;inhibition] HLA-C PCBP1 [activation] CCDC88C MAPK8 [activation] TPT1 PTEN [activation] RAB2A FAM114A1 [activation] HNRNPA1 ITGA4 [activation] DYSF SAMHD1 [activation] RRP15 SRPK3 [activation] ANAPC2 EPHA4 [activation] CD93 KNG1 [activation] STK24 STK11 [activation] CTNNB1 HNRNPA1 [activation] PTEN GPR113 [activation] MAPK14 SPAG9 [inhibition] MON1A TAB1 [inhibition] MCC EIF2B1 [activation] ERRFI1 FGFR2 [activation] NOS1 ATP2B4 [activation] CRX NPAS2 [activation] ENO1 MDM2 [activation] STAP2 MYD88 [activation] YES1 TP53BP2 [activation] RRP1 OBSL1 [activation;inhibition] CDK6 PPARGC1A [activation] NR3C1 NR2F2 [activation] EGFR DIMT1 [activation] LIPE MAPK1 [activation] PTBP1 HMGA2 [activation] EPB41L1 DRD2 [activation] PRTN3 F2R [activation] SDCBP EFNB1 [activation] MYC NUP98 [activation] GRB2 ANXA2 [activation] TFAP2A COL1A2 [activation] MDM2 XIAP [activation] MYH11 MAPKAPK5 [activation] PPP1R3D EPM2A [inhibition] CDK11B RARA [activation] RRAS2 ARHGEF2 [activation] AVP AVPR1A [activation] TXN TP53 [activation] HSPA4 RPTOR [activation] MIF NME1 [activation] PTH PTH1R [activation] CAV1 RAB27B [activation] CARM1 NCOA1 [activation] SRSF12 EIF4A3 [activation] FKBPL TSSC1 [activation] PIK3R1 WBP11 [activation] GPR37 SLC6A3 [activation] NCAM1 RHEB [activation] BET1 GOSR1 [activation] AKAP4 AKAP3 [inhibition] SOD1 PPP3CA [inhibition] TNIK GSN [activation] HSP90B1 MDM2 [activation] PPP1R16B TGFBR2 [activation] SLX4 PLK1 [activation] CCNA2 HERC5 [inhibition] JUND MAPK1 [activation] ESR2 RPS6 [activation] PAK1 SMAD2 [activation] HCST PIK3R1 [activation] BUB1 FANCC [activation] TRIM28 STAT1 [activation] GNAZ OPRD1 [activation] TNFSF11 TRMT2A [activation] MDM2 JUN [activation] YPEL3 SRPK1 [activation] CASP3 RBX1 [activation] GNS SRC [activation] LZTR1 TBX2 [activation] EIF2S3 DCC [activation] 页 143 共 454


2016/4/8 19:14

STAT2 IWS1 [activation] CAMK2B RPL11 [activation] PTEN CCDC180 [activation;inhibition] FMR1 PRKAA1 [inhibition] ACTA1 CBL [activation] MAPK13 MAP3K4 [activation] SMURF1 ACAP2 [inhibition] DDX1 ATM [activation] THBS1 COL1A1 [activation] CFL1 EGFR [activation] PSENEN GSAP [activation] VCAM1 TLN1 [activation] TAF1 CCNA2 [activation] RRAGD RRAGB [activation] LUC7L2 EXOC1 [activation] PAK3 SYN1 [activation] PRKAA2 ULK2 [inhibition] IGHG1 FGA [activation] NUP62 SSC5D [activation] URM1 OGT [activation] LRRK2 LIMS2 [activation] FTSJ1 SGTA [activation] IRF7 TRMT2A [activation] GTF2B HSF1 [activation] PML CHEK2 [activation] CDK3 HSP90AA1 [activation] HIST1H3A PRKDC [activation] NAA15 UBA5 [activation] HNRNPA1 GRB2 [activation] AP4E1 ARF1 [activation] BRIP1 PALB2 [activation] COL1A2 DCN [activation] GNG8 GNB1 [activation] CDK5 HDAC4 [activation] CALM1 CCNE1 [activation] DDX5 TP53 [activation] TICAM1 AZI2 [activation] SRPK1 AHCYL1 [activation] SP1 EGR1 [activation] KCTD5 RAPGEF2 [activation] TEC PTPRJ [activation] VDAC3 CD4 [inhibition] RHEB ECSIT [activation] ATM TTI2 [activation] FOXE1 PLCB3 [activation] ADAM17 PTPN3 [activation] ANXA7 CPNE6 [activation] MDM2 HNRNPA1 [activation] FANCA DDX39B [activation] MAD2L2 CDC20 [inhibition] PRKCA HABP4 [activation] ITK FGFR1 [activation] CORO2A RB1 [activation;inhibition] IRS2 RPTOR [activation] DNAJA3 CDC42 [inhibition] CHD4 ITGA4 [activation] KRR1 SRPK1 [activation] OBSL1 ACSL3 [activation;inhibition] CHEK2 TSSK1B [activation] LRP1 APOA5 [activation] RASGRF1 NTRK1 [activation] PTPN1 ITGB1 [activation] ACACA RIOK2 [activation;inhibition] YAP1 FASN [activation] IL33 IL1RL1 [activation] SUMO3 CDK11A [activation] PSEN2 PSENEN [activation] SMS MAPKAPK3 [activation] TACC1 AURKB [activation] SOX2 CDK11A [activation] CDK1 ECT2 [activation] RPL18A LPL [activation] SERTAD4 PPP2R1A [inhibition] ERBB2 FGR [activation] ADAMTSL3 NOTCH2NL [activation] BMPR1B SASH3 [activation] 页 144 共 454


2016/4/8 19:14

IQGAP1 SHC1 [activation] RAD21 NUMA1 [activation] BMP4 FSTL1 [activation] HLTF NOTCH1 [activation] JAK2 STAM [activation] TNF ATP2A2 [activation] CD28 IL12A [activation] KLK6 PALB2 [activation] LYN PTPRC [activation] PPP2CA VDR [activation] FHL1 RBPJ [inhibition] MAPK3 PTPRC [activation] CFTR HSPA2 [activation] RPA3 NEURL4 [activation] MYB CEBPE [activation] FAM65B MAP2K2 [activation] ABI2 HGS [activation] CDK4 DDAH2 [activation] TAGLN2 TRAF6 [activation] ELAVL1 SRPK1 [activation] CSK EGFR [activation] SYK STAT1 [activation] CAPNS1 PPARGC1A [activation] PRKDC PCNA [activation] RPP14 IGSF21 [activation] SFN ATF2 [activation] IKBKB TUBB [activation] CSNK2A2 ACACA [activation;inhibition] DDX21 VCAM1 [activation] NXF1 ABR [activation] TFAP2A APC [activation] PLG IGF2 [activation] FLT1 HSPG2 [activation] GAB2 MAPK4 [activation] ARHGAP24 ROCK1 [activation] CBY1 CTNNB1 [activation] HIST1H3A ICAM1 [activation] XDH BTN1A1 [activation] DDX5 CREBBP [activation] WWTR1 PAX3 [activation] BTRC MAPK14 [activation] SMURF1 PAK1 [activation] FAM175B TP53 [activation] SLAMF6 ZAP70 [activation] TGFBR1 DAB2 [activation] LRRK2 CYFIP2 [activation] CDK5 C2CD5 [activation] NPAS4 ARNT2 [activation] FGFR1OP2 STK24 [activation] PAXIP1 CDC20 [activation] GDI2 SGK1 [activation] OGT CSNK2A1 [activation] LLGL2 PARD6B [activation] RBM48 TRIB3 [inhibition] SH2D1B DAPP1 [activation] HBA1 SPP1 [activation] BUB3 SMAD2 [inhibition] RAB13 RPA2 [activation] SMC2 EGFR [activation] EGFR PKIA [activation] PIP5KL1 PIP5K1C [activation] UBE2R2 GABARAPL2 [activation] TBK1 SYK [activation] TNIK CTNNB1 [activation] TBP GTF2A2 [activation] GRB2 COX6A1 [activation] MAPK13 YWHAB [activation] TEKT1 CCHCR1 [activation] C14orf1 BID [activation] F2 SPP1 [activation] TNNT1 FYN [activation] EGFR SLA2 [activation] GPSM1 ZBED1 [inhibition] MN1 EP300 [activation] CREBBP HOXA9 [activation] CDKN2B PYCRL [activation;inhibition] 页 145 共 454


2016/4/8 19:14

SETDB1 LUC7L2 [activation] TGFB1 AXIN2 [activation] RAC3 CREBBP [activation] NOTCH1 CBL [activation] PDPK1 ILK [activation] SULT1A1 STK4 [activation] TRIM25 STK11 [activation] EIF2AK3 IKBKB [activation] CDC37 LRRK2 [activation] ITGA4 PRKDC [activation] DRD3 EPB41L1 [activation] MYC SIRT5 [activation] LEFTY2 ACSS3 [activation] CTNNB1 FOXO3 [activation;inhibition] CDK4 RELA [activation] ABL2 ERBB2 [activation] ATF1 GABPB1 [activation] DEFB1 CCR6 [activation] CFLAR GSN [activation] CASR PRKCA [activation] SDF2L1 EGFR [activation] RAB5B LRRK2 [activation] CRY1 TRAF2 [activation] PIK3CD IL3 [activation] APBB1 MAPK8 [activation] ARHGAP24 APP [activation] RBL2 UBTF [activation] XRCC2 RAD51C [activation] BAX SLC25A4 [inhibition] CTNNBIP1 CTNNA2 [inhibition] F8 EIF1B [activation] ITGB1 CCDC8 [activation] MAP2K4 CYLC2 [activation] MYO1C CBL [activation] PPP6C PPP4C [inhibition] TGM1 HSPB1 [activation] GLMN EIF3A [activation] BAD HRK [inhibition] CALM1 YWHAE [activation] SRPK2 DIDO1 [activation] TERT YWHAQ [activation] IRAK1 CAMKK2 [activation;inhibition] PTK2 DDX39A [activation] HSPA1A YWHAB [inhibition] OPRD1 ADRB2 [activation] SSSCA1 CCNH [activation] HSP90AB1 STK38L [activation] IL7R STAT5B [activation] RPS19 LRRK2 [activation] PAK1 CHORDC1 [activation] ITCH FYN [activation] CDC5L HNRNPA1 [activation] KCNJ2 KCNJ4 [activation] CAMK2A ITGB1BP1 [activation] SIMC1 YWHAG [activation] EIF2S3 CASP4 [activation] WIPF1 GRB2 [activation] CASP8 PRSS50 [inhibition] CDC37L1 XPO1 [activation] ZFYVE9 EIF4G1 [activation] MEF2A GNG12 [activation] MESDC1 LRP6 [activation] OSM COL4A1 [activation] FAM46A ZFYVE9 [activation] EIF4E2 EPAS1 [inhibition] GAB2 ZAP70 [activation] ANAPC1 TP53BP1 [activation] TP53 C10orf90 [activation] EGFR PIM1 [activation] CD84 SH2D1A [activation] SDC4 DVL1 [activation] PTPRU GNAI2 [activation;inhibition] TP73 HRAS [activation] MTOR RPTOR [activation;inhibition] CDK17 PPP2R2A [activation] LCK FAS [inhibition] 页 146 共 454


2016/4/8 19:14

ADAP1 PRKCZ [activation] PDIA2 CRK [activation] SH3KBP1 BCAR1 [activation] CD3E PIK3R2 [activation] JAK1 HSP90AB1 [activation] CTTN ABL2 [activation] MEOX2 ARHGEF7 [activation] NUP155 TRAF6 [activation] NXF1 FLAD1 [activation] IRF3 SMAD2 [inhibition] MAP2K1 PPARG [activation] APBB1 U2AF2 [activation] USP7 BUB3 [inhibition] YWHAB CDK18 [activation] INS APP [activation] KLC4 YWHAB [activation] PRKCB DDX58 [activation] GTF2I BCL2L11 [activation] CREB3 RIMS3 [activation] FKBPL SETDB1 [activation] RPTOR TRAF6 [activation] NFKBIB RXRA [inhibition] ARHGAP15 PRNP [activation] CALM1 CCND2 [activation] NFKBIA ACTG1 [activation] EVX1 RAD21 [activation] GNB1 PLEKHG2 [activation] GAST MEP1B [activation] HOXD9 HMGB1 [activation] KIAA1109 CTNNB1 [activation] MMP14 FGFR4 [activation] MAP2K7 PIK3R1 [activation] CNOT10 LYN [activation] PPP1R1A PPP1R15A [inhibition] LUC7L3 SRPK1 [activation] IKBKG ANXA1 [activation] ADRB2 IL6R [activation] SRPK1 SRRM2 [activation] ARHGEF2 YWHAH [activation] ATR NCOA2 [activation] SERPINA5 F11 [inhibition] EPHA8 ANKS1B [activation] SOX2 SMC2 [activation] SIRT3 HSPA4 [activation] DDX39B THOC3 [activation] CTF1 MAGEA6 [activation] CORO1C BTK [activation] RPA1 RAB1A [activation] MYC POLE [activation] SRPK2 EPB41L1 [activation] PTN PLXNB2 [activation] EHD1 IGF1R [activation] ADRBK1 ACACA [activation;inhibition] EIF4EBP1 KLHL25 [inhibition] EIF2AK2 FARSB [activation] CCND1 SKP1 [inhibition] STK11 SNRK [activation] ERCC6 CHEK2 [activation] HSP90AA1 RPS6KA5 [activation] EGLN3 ABI2 [activation] IKBKB CCAR2 [inhibition] MANF MDM2 [activation] UBE2E3 RANGAP1 [activation] SERBP1 CTNNB1 [activation] PTEN PPP1CA [activation;inhibition] RAB23 ARFGAP1 [activation] SMAD3 CTNNB1 [activation] MOS NUDCD3 [activation] MCM7 CDKN1C [inhibition] PIK3CA DDX5 [activation] GLRX3 ITGA4 [activation] TERT DKC1 [activation] ARHGEF11 CRK [activation] PIAS4 SERPINA5 [inhibition] TRIM65 SRPK1 [activation] RALB ULK1 [inhibition] 页 147 共 454


2016/4/8 19:14

CD48 IL18RAP [activation] CTCF POLR2A [activation] BMX FADD [activation] IQGAP1 CALM1 [activation] EIF2S2 CRMP1 [activation] CYLD CAMK2D [inhibition] RPL37A TP53 [activation] DIRAS3 PTPN1 [activation] VCAM1 HIP1 [activation] EP300 DDX5 [activation] RAD51 RAD54L [activation] CFL1 APP [activation] LRRK2 SFXN1 [activation] PGAM5 EIF4A3 [activation] PFN2 FLT3LG [activation] GPN1 RPAP3 [activation] UBE2V1 UBE2N [activation] ILK RAF1 [activation] NOTCH2NL SNAI1 [activation] DOCK8 RHOJ [activation] PIK3R1 LCP2 [activation] SP1 STAT3 [activation] MYC POLD1 [activation] MAPT SGK1 [activation] HECTD1 APC [inhibition] STAMBP RECQL5 [activation] FYN CD2AP [activation] HSPB1 CT55 [activation] FASLG PIK3CA [activation] YWHAZ SSFA2 [activation] PHLDB2 MYC [activation] TP53 ZCCHC10 [activation] DKK3 PPM1D [inhibition] APP CDKN1A [activation] EIF4A1 CDC5L [activation] ERBB2 KDELR2 [activation] TBP NFYB [activation] CDK1 HIST1H2BB [activation] CCR5 PTK2 [activation] MOK INSR [activation] TXLNA SPERT [activation] TNIK NUDC [activation] ERBB2 STAT3 [activation] MLLT4 CCDC8 [activation] AAR2 GJA5 [activation] RNF114 TRAIP [activation] SERPINA3 CTSG [inhibition] SMAD4 AKT1 [activation] SGTA IL8 [activation] TOP1 ATM [activation] MYO3B GRB2 [activation] ACTB PCK1 [activation] LTA BIRC2 [activation] SRPK3 PDCD11 [activation] TBXA2R YWHAZ [inhibition] MLH1 TRIM23 [activation] HSP90AA1 STK32B [activation] ACTN1 MDM2 [activation] RAD21 CCDC170 [activation] CDKN2C ATM [activation] CASP9 HIP1 [activation] BACE1 RANBP9 [activation] EIF2B2 EGFR [activation] CASP7 SAT1 [activation] FBN3 BID [activation] STOM DVL3 [activation] MSANTD3 SUV39H1 [activation] GATA1 CREBBP [activation] HSF1 CSNK2A1 [activation] MYL3 FTH1 [inhibition] LRRK2 CDC25A [activation] MAPK14 CCDC8 [activation] NUDC ERBB2 [activation] MBL2 MAD2L1 [activation] AR RB1 [activation] ITGB1 ANKS1B [activation] 页 148 共 454


2016/4/8 19:14

RIC8A GNAI3 [activation;inhibition] EGFR RAPGEF1 [activation] LMO2 ISL1 [activation] RACGAP1 VAV1 [activation] PRR20C DAB1 [activation] LXN KIAA1009 [activation] TNFSF10 ZDHHC17 [activation] BTK TLR8 [activation] HSPE1 ATF2 [activation] PRKCB IFNAR2 [activation] BCL2 PPP3CA [activation] CAMKK2 ATG4B [activation] EGFR MAP2K3 [activation] MAP3K3 PRKDC [activation] PAXIP1 AAMP [activation] F2RL2 F11R [activation] FGFR2 GLCE [activation] LRRK2 HMMR [activation] SOCS1 FLT3 [inhibition] RPAP3 TGFBR1 [inhibition] PRKCA PFKFB1 [activation] JAK2 PTK2B [activation] RIC8B LRP1 [activation] HIST1H3A AIRE [activation] PLK1 EGFR [activation] ICT1 FASTKD2 [activation] VDAC1 BAX [inhibition] FOXO1 CDKN1A [activation] SIRT1 MAP2K4 [activation] PTP4A3 STAT1 [activation] ESR2 CNN1 [activation] PEBP4 RAF1 [activation] SCXA SOX9 [activation] INHBA INHA [activation] SKP1 FBXL3 [inhibition] MAZ MAPK14 [activation] TNFSF10 TNFAIP3 [activation] DYRK2 RAD54B [activation] CDK5R2 ACTN1 [activation] HSP90AA1 PDPK1 [activation] BARD1 SRSF1 [activation] PAK1 GRB2 [activation] LRWD1 HIST3H3 [activation] JUN SPI1 [inhibition] FBXO6 DNAJA1 [inhibition] EP300 SP3 [activation] FICD RAC1 [activation] ANXA5 UBC [activation] ITGAM FGG [activation] RPS6KA1 SYK [activation] SMAD2 CHGB [activation] TSC2 PIN1 [inhibition] NGB CCDC36 [inhibition] MMP7 DCN [activation] SMAD2 GLI3 [activation] CALM1 NRGN [activation] GABARAPL2 PFN2 [activation] HSPA5 EGFR [activation] FHL3 CSF1 [activation] LZTS2 DYRK1A [activation] SOCS3 RELA [inhibition] RPA1 POLR2A [activation] DCN COL4A1 [activation] TERT CIB1 [activation] CIT RAC1 [activation] F10 PROS1 [inhibition] BMP8B ABL1 [activation] MAGED1 PLK1 [activation] BTK AR [activation] CD81 EIF4A1 [activation] DDX21 WHSC1 [activation] VKORC1 ILK [activation] CDC5L SMARCB1 [activation] DOK4 ERBB2 [activation] SMAD5 U2AF2 [activation] CDC23 MDC1 [activation] 页 149 共 454


2016/4/8 19:14

NUPL2 GLE1 [activation] HIF1A MAFK [activation] HSD11B2 CTBP1 [activation] VCAM1 SAR1B [activation] MET FES [activation] PTGES3 IRS4 [activation] MYOD1 ID4 [activation] HSPG2 ESR2 [activation] HES5 JAK2 [activation] CRK FCGR2C [activation] HSF1 PTGES3 [activation] FBXO17 SKP1 [inhibition] RPS6 HSP90AB1 [activation] HSPB1 PALM3 [activation] ILK SLC4A1AP [activation] CD8A LAT [activation] MEF2A UBE2I [activation] VCL TGFB1I1 [activation] IL3RA PPP1CC [activation] GADD45B GADD45GIP1 [activation] PPP1R3D FYN [activation;inhibition] GPRASP1 GRM5 [activation] FZR1 TTK [activation] TTN MYC [activation] HOXC8 GRB2 [activation] MAPK8 MAP1B [activation] EIF4A3 SRPK2 [activation] SNCA HTT [activation] JAK2 ALK [activation] ICAM1 RPL5 [activation] CLSPN ATR [activation] UBXN11 PRKAA1 [inhibition] YES1 HSP90AB1 [activation] PRKAA2 STIM1 [activation] MAPK8 EP300 [activation] HIF1A NCOA2 [activation] PORCN WNT1 [activation;inhibition] JUP MAP1LC3B [activation] PRKCB LSP1 [activation] HMGN3 GRB2 [activation] LRRK2 RHOA [activation] APOL1 CDC23 [activation] CAV1 LATS1 [activation] TMED10 TRAF6 [activation] NOXA1 RIMBP3 [activation] SDC3 FGF2 [activation] SDC2 SDC3 [activation] ADRA1D NOS1 [activation] RADIL GRB2 [activation] TAGLN IGF1R [activation] DAPK1 TWF1 [activation] RHOB PGGT1B [activation] CDK6 PML [inhibition] ADRB2 GRB2 [activation] DOK1 PTPN11 [activation] PRKACB PITX2 [activation] NCF1 IL4R [activation] TP53 PEO1 [activation] ATM RNF20 [activation] RIMS2 RAPGEF4 [activation] EIF4A3 HIST1H2AA [activation] IRAK1 MAP3K3 [activation;inhibition] FTH1 GRB2 [activation] HDAC1 BUB1 [activation] CBL PTPRJ [activation] MCM3 POLR2A [activation] GABARAPL2 DDX17 [activation] KRIT1 PIK3C3 [activation] MMP17 MMP2 [activation] GNA14 CXCR1 [activation] RHOC RTKN [activation] YES1 GAB1 [activation] VCAM1 RANBP1 [activation] CBL YWHAG [activation] PTBP3 GCN1L1 [activation] A2M MYOC [inhibition] 页 150 共 454


2016/4/8 19:14

ABL1 ARHGEF11 [activation] CEBPG FOS [activation] SUMO1 PRKAA1 [activation] CTNNB1 FOXM1 [activation;inhibition] CTSV BRAF [activation] HSP90AA1 PAFAH1B1 [activation] HSPB1 VCAM1 [activation] MET FBXO6 [inhibition] EHMT2 BANF1 [activation] KALRN ENO3 [activation] MLXIPL MLX [activation] ATP1A1 ERBB2 [activation] FOXP2 FAM124A [activation] ERBB2IP SMAD3 [inhibition] PIGR CDK6 [activation] VCAM1 HSPA9 [activation] ESR1 PIK3CA [activation] TNFRSF11B THBS1 [activation] CTR9 CIAO1 [activation] NOTCH2NL NPBWR2 [activation] EZR WHSC1 [activation] GRB2 RALGPS1 [activation] IRF2 PRKACA [activation] MME IRAK2 [activation] TFAP2A RHOA [activation] SHB CRK [activation] PRNP HSPA4 [activation] NUP107 LRRK2 [activation] FBXO6 ITPRIP [inhibition] GATA4 ALX4 [activation] HSPA1L NFKB1 [activation] RB1 CEBPA [activation;inhibition] STAG1 CALM1 [activation] NOL11 MARK3 [activation] F12 APOH [activation] XIRP2 LRRK2 [activation] SMC1A MLH1 [activation] TSC2 GRB2 [activation] IGFALS IGF1 [activation] SNW1 NBN [activation] MYC HIGD1A [activation] DYRK1A RNF169 [activation;inhibition] MBP CDK7 [activation] ICAM1 HNRNPA2B1 [activation] TYSND1 HSD17B4 [activation] VCAM1 PPP2CA [activation] SMC3 NOTCH1 [activation] MDC1 PAXIP1 [activation] PLG CXCL2 [activation] IRF3 MAPK8 [activation] HIST1H1C EIF2AK2 [activation] SHE ABL1 [activation] DYRK1B PAK1 [activation] ELANE LRP1 [activation] TP53 BTRC [activation] TNFRSF14 ESR1 [activation] LXN MAGEB2 [activation] PTPRC LEPR [activation] SGSM3 RAB5A [activation] CRK BUB1 [activation] CXCL12 PF4 [activation] STAT5A IL2RB [activation] BCAP31 APP [activation] MYB SUMO1 [activation] KMT2A TP53 [activation] TULP3 RYR1 [activation] GMNN CASP3 [activation] SHC1 CDH5 [activation] HOMER1 RYR2 [activation] MAP1LC3A STK4 [activation] NFKBIL1 LUC7L [activation] HSPA8 HERC5 [inhibition] HEMGN BUB1 [activation] EZR TRAF6 [activation] KIF23 NXF1 [activation] GADD45GIP1 GADD45G [activation] 页 151 共 454


2016/4/8 19:14

IL37 SMAD3 [activation] DVL1 DAAM1 [activation] TP53 MAGEA2 [activation] CD19 CD82 [activation] CCL13 MMP3 [activation] NCF1 PRKDC [activation] STRAP HSF1 [activation] AURKB RASSF1 [inhibition] SRPK1 HBS1L [activation] GNB1 GNGT1 [activation] CD9 ADAM10 [activation] CCDC151 SUV39H2 [activation] GSK3B SNAI1 [activation;inhibition] NFKB1 SPI1 [inhibition] BHLHE41 HDAC1 [activation] APC CFTR [inhibition] SOX2 YPEL5 [activation] IKBKE IKBKB [activation] PHC2 MAPKAPK2 [activation] GRB2 GAREML [activation] APP ANXA2 [activation] RHPN2 SMURF1 [inhibition] CYFIP2 BIRC3 [activation;inhibition] CARM1 E2F1 [activation] URM1 VIPR2 [activation] SMAD2 TRIM62 [activation] FST ANG [inhibition] RHOG VAV3 [activation] HIST1H4A GNB2 [activation] IKBKB HSPA1L [activation] ITGB1 DAG1 [activation] HLA-B STMN1 [activation] PAXIP1 COMTD1 [activation] TP53 TDRD12 [activation] SOX8 OLIG2 [activation] BTRC OGT [activation] RPA1 PSIP1 [activation] MLST8 RPTOR [activation;inhibition] NXF1 NIPSNAP1 [activation] YES1 NIF3L1 [activation] TPT1 FANCA [activation] NCOA2 FOS [activation] FAM117B DYRK1A [activation] MLLT4 PVRL3 [activation] APC NUP153 [activation] ZBTB16 CASP3 [activation] EP300 STAT5A [activation] EIF2S1 SNW1 [activation] ILK DPM1 [activation] NCOA3 AR [activation] EPOR SYK [activation] HIST1H4A ITGA4 [activation] PML SUV39H1 [activation] BCAR1 PPAP2B [activation] CHN1 CDK5 [activation] CBLB PTK2B [activation] NUMBL GRIP1 [inhibition] ARL8B TUBB [activation] HSP90AB1 DDR1 [activation] PTPRF EGFR [activation] CDC25B YWHAE [activation] PPARG SETDB1 [activation] DDX3Y CD81 [activation] TNF LTA [activation] PPP2R1B STK24 [activation] SIK3 SMAD3 [activation] TERT TEP1 [activation] UBE2I AURKB [activation] CD1D P4HTM [activation] TRPM7 PLCG1 [activation] PSEN1 TGFBR1 [activation] MYO16 PIK3R1 [activation] BLID FGFR4 [activation] MDM2 LUC7L2 [activation] GFPT1 HLA-B [activation] NXF1 SFXN4 [activation] 页 152 共 454


2016/4/8 19:14

TNFRSF13B TRAF2 [activation] STAT1 SMURF1 [activation] SFPQ PTK6 [activation] RANBP9 DDX4 [activation] DIABLO NR4A1 [activation] SNAP23 WASH2P [activation] CCND1 LPL [activation] APP FHL2 [activation] INSR GAB1 [activation] VCAM1 EIF4A1 [activation] EPHA3 CRK [activation] SMC4 RAD21 [activation] C22orf43 C19orf66 [activation] NUDCD3 EGFR [activation] CDC25A CCNI [activation] LATS1 KIAA1549 [inhibition] ATAD3A GRB2 [activation] URM1 USP47 [activation] ARFGAP1 RAD52 [activation] SIRT6 ANAPC1 [activation] SRC PGR [activation] GNAT2 ADRB2 [activation] KAT2A PPARGC1A [activation] CDK1 MBP [activation] H2AFX PEF1 [activation] EPPK1 CDKN1A [activation;inhibition] HDAC1 NOTCH1 [activation] SH3BP2 SYK [activation] SMAD4 STX17 [activation] GRIP2 GRIA3 [activation] PTPN4 CRK [activation] VAV2 SOCS1 [inhibition] C6orf211 ARF6 [activation] S100A10 CDK16 [activation] RAC1 PTK2 [activation] SMAD4 STK35 [activation] ATF4 MOV10 [activation] NUMA1 GNAI1 [activation] GET4 HSPB1 [activation] CPLX2 STX3 [activation] SETDB1 HDAC1 [activation] GUCY1B3 GUCY1A2 [activation] PIK3C2A EGFR [activation] VCAM1 NUP93 [activation] GRB2 PDE6G [activation] GADD45GIP1 NFE2L2 [activation] RACGAP1 YWHAG [activation] SRPK2 U2AF1 [activation] LRRK2 SSR4 [activation] CXCR5 GNAI2 [activation] CD81 HNRNPA3 [activation] RAN STAU1 [activation] ARPC1B APP [activation] ZBTB17 IRF8 [activation] PARD3 PARD6G [activation] SH3D19 SOS2 [activation] IQGAP1 CYBB [activation] TRAF3 TNFRSF13B [activation] FOXF2 ABL1 [activation] HLA-C EIF3F [activation] CDC37 PRKCI [activation] PACSIN1 GAS7 [activation] ECSIT MAST1 [activation] SLC6A12 SCRIB [activation] SYK KIT [activation] YWHAQ HSPA1A [inhibition] BATF3 ATF2 [activation] HNRNPA0 ITGA4 [activation] RAPGEF4 BZRAP1 [activation;inhibition] IRAK1 IRAK4 [activation;inhibition] POLD1 POLD2 [activation] PAXIP1 PDCD11 [activation] EPHA8 G3BP1 [activation] ACVR1 UBE2E3 [activation] OSCAR FCAR [activation] SRC CDH5 [activation] 页 153 共 454


2016/4/8 19:14

EIF2B3 GOLM1 [activation] MAP2K1 HSPA8 [activation] BCL2L1 BNIP3 [activation] RPS6KA5 HIST2H2BE [activation] RAC3 ESR1 [activation] HDAC1 CDC20 [inhibition] DYRK1A SIPA1L1 [activation] CUL1 HSPA1L [inhibition] TERF1 KPNB1 [activation] JUNB SMARCA4 [activation] CASP12 NOD2 [inhibition] CCDC8 HLA-C [activation] IKBKG KIF23 [activation] CDK4 KAT2A [activation] SHC1 GAB1 [activation] AURKB PPP1CA [activation] PRKAR2B PRKACA [activation] PRKCA NFATC1 [activation] STAT4 MAP2K6 [activation] PRKD3 TAF1 [activation] IRS4 PPP2R1A [activation] EDA2R TRAF3 [activation] YWHAZ NCKAP1 [inhibition] STK4 MAP1LC3C [activation] YWHAZ GCN1L1 [activation] RPS17 GABARAP [activation] SEMA4C NCDN [activation] TNFRSF14 APP [activation] DOCK2 VAV1 [activation] HSPG2 PRELP [activation] EDN3 EDNRA [activation] TRAF2 TEKT3 [activation] IKBKB PPP1R15A [activation] TUBA4A GRB2 [activation] SGOL1 PPP2CB [inhibition] KIAA1598 FABP3 [activation] CD5 CD79A [activation] JUN HSP90AA1 [activation] PIK3C3 CLPTM1L [activation] CTNNB1 CCNA1 [activation] MAPK1 PRKCZ [activation] RPTOR GNB1 [activation] LTBP1 SMURF1 [inhibition] GABARAPL1 GSN [activation] EEA1 BMI1 [activation] HBZ HBD [inhibition] SP1 SKIV2L2 [activation] TRAF6 MAP2K1 [activation] SAV1 PTPN14 [activation] CASP8 FIS1 [activation] GSK3B RPL36AL [inhibition] YAP1 CCDC85C [inhibition] MAP1LC3B ATG10 [activation] BUB1B CDC20 [inhibition] RPA3 RAB7A [activation] OBSL1 PHIP [activation] PAX6 IPO13 [activation] AMBRA1 PIK3C3 [activation] MYC MRPS34 [activation] PARD3B SMAD2 [activation] KSR2 HSP90AB1 [activation] GPR183 MTA1 [activation] CD247 SH2B3 [activation] HES1 YWHAB [activation] RELA NKX2-1 [activation] APC EPAS1 [inhibition] RAN SLX1A [activation] FGB ASB7 [activation] TBC1D3F CDC42 [activation;inhibition] GNB2L1 FYN [activation] FANCB F3 [activation] SDC4 SGTA [activation;inhibition] SMAD1 PAK1 [activation] CYLD AURKB [inhibition] SKIL IL36RN [activation] YWHAH MAP3K2 [activation] 页 154 共 454


2016/4/8 19:14

ABL1 RAPGEF1 [activation] PRKAA2 NOTCH2NL [activation] RANBP2 SNW1 [activation] CD44 SLC7A11 [activation] GRB2 ITPR3 [activation] ADRM1 INSIG2 [activation] GH2 GHR [activation] IRF2 PPP3CA [activation] CASP3 LMNB1 [activation] PTEN PTK2B [activation] CTGF FGFR1OP [activation] IL24 APC [activation] MASTL RPS6KA1 [activation] NFKBIA G3BP2 [activation] MAPK7 JUP [activation] TERF1 ACD [activation] ARPC1B PAK1 [activation] NR1H3 SIRT1 [activation] GABARAPL2 PRMT1 [activation] EIF2S2 PLEKHM1 [activation] SIRT1 RICTOR [activation] SLC9A3R1 GNAQ [activation] LRRK2 DVL3 [activation] IGHA1 CDH1 [activation] GRB2 AMBP [activation] CASP2 GRB2 [activation] VIPR1 VIP [activation] CDK5R1 CDK3 [activation] MASP1 SERPING1 [inhibition] NR0B2 ZAP70 [activation] NR3C1 RPS6KA5 [activation] HSPB1 TRIM54 [activation] RASSF1 MOAP1 [inhibition] TEC PTPRC [activation] CREBBP KAT2A [activation] DDX39B VCAM1 [activation] CRK HSPA6 [activation] TICAM1 TRAF1 [activation] HSPA4 CDC25C [activation] TP63 SMAD2 [activation] MEGF10 HDAC4 [activation] EIF4G1 HSPB1 [activation] EIF2S3 IKBKE [activation] SARNP DDX39B [activation] OBSL1 DDX56 [activation] RANBP2 AXIN1 [activation] JAG1 NOTCH2 [activation] TP53 RPA1 [activation] CD4 GNAI2 [activation] FAM83B YWHAB [activation] RPP38 SRC [activation] HNRNPL HNRNPA1 [activation] PRKDC HSP90AA1 [activation] S100A14 CASP8 [inhibition] CHGB APP [activation] RRP36 OBSL1 [activation;inhibition] RPS20 PIK3CA [activation] GABARAPL2 TTBK1 [activation] NR1H3 KAT2B [activation] MAPKAPK2 ELAVL1 [activation] IGHM RUNX1 [activation] USHBP1 CCDC116 [activation] S100A4 HBEGF [activation] STK32C GRB2 [activation] TGFBRAP1 ACVR2B [activation] SNCA TH [activation] CCAR2 PYHIN1 [inhibition] EXOC6 EGFR [activation] SNW1 SMC4 [activation] INADL CLDN1 [activation] NR3C1 CEBPB [activation] NUP153 MAPK14 [activation] CDK3 CDKN3 [activation] CTR9 MYC [activation] GNAI2 EGFR [activation] DDX58 UBE2D2 [activation] 页 155 共 454


2016/4/8 19:14

LINC00526 USHBP1 [activation] CRK PLSCR1 [activation] SCO2 MYC [activation] HOXD9 PKNOX1 [activation] CDK1 NDEL1 [activation] CDC27 CDC20 [inhibition] SRC YWHAE [activation] HSP90AA1 TERT [activation] PF4 THBD [activation] CBL YWHAB [activation] ANXA2 GH1 [activation] ITGA4 VAPA [activation] CTLA4 FYN [activation] AGTRAP HSPA4 [activation] FBXO25 CDK5RAP2 [activation] EP300 NCOA3 [activation] CASP3 MAP4K1 [activation] PINX1 TERF1 [activation] MYO18A VCAM1 [activation] PRL BMP1 [activation] WDR20 YWHAB [activation] DDX5 CALM1 [activation] RIPK2 XIAP [activation] YWHAB CTTN [activation] SUMO1 ACTB [activation] EHMT2 SOX2 [activation] ELF4 SKP2 [activation] FGF7 HSPG2 [activation] MAP2K1 PTPRJ [activation] LILRB2 PTPN6 [activation] WDR48 CTNND1 [activation] PRKCI MAP2K5 [activation] IL10RB IL10RA [activation] AURKA HMMR [activation] FBXO30 ACVR1 [activation;inhibition] SRPK2 DDX39B [activation] TRA2A BARD1 [activation] RAB5C TRAF6 [activation] TGFBR2 ARHGEF7 [activation] SHC1 HSPA6 [activation] ATP6V1A VAMP8 [activation] PPP2CA TWIST1 [activation] IFI16 E2F1 [activation] GRB7 SETDB1 [activation] MYC IDH3A [activation] EPHB6 NOTCH2NL [activation] RFXANK RFXAP [inhibition] MYC PTPN14 [activation] ITGA4 PRRC2C [activation] SELPLG TPST2 [activation] CCDC8 STX7 [activation] NR3C1 HNRNPA1 [activation] VPS26A ILK [activation] SV2A ETS1 [activation] ARL14EP SETDB2 [activation] APP TGFB2 [activation] MAML1 MAML2 [activation] POP5 CAMK2B [activation] C17orf85 OBSL1 [activation;inhibition] GRN CCNT1 [activation] SERBP1 MAPK13 [activation] CDKN2C TLE1 [inhibition] CTNNB1 KAT2B [activation] TBXA2R PRKACA [inhibition] CDK1 SFN [activation] NFATC1 HDAC1 [activation] STX7 UBL4A [activation] YWHAB MST1R [activation] FZR1 SETD8 [activation] PTPN7 PRKACA [activation] MBTPS1 SPHK1 [inhibition] ITGA4 HIST2H2BF [activation] HSPB1 EPB41L1 [activation] DLX4 SP1 [activation] NCAM1 EGFR [activation] PRMT1 HLA-C [activation] 页 156 共 454


2016/4/8 19:14

VTN POMC [activation] HNRNPA1 PRKDC [activation] EIF2B1 ARL4D [activation] CCNE1 ARHGEF5 [activation] C9orf156 SRC [activation] IQGAP1 IKBKB [activation] RAC2 CD81 [activation] MST1R SFN [activation] DLG3 PTK2B [activation] PPP1R15A HSPA8 [inhibition] TWIST1 CHD4 [activation] VDAC1 CASP4 [inhibition] GATA1 SPIB [activation] INHBA FSTL3 [activation] NOTCH1 MOB1A [activation] SIRT1 PIK3R1 [activation] HSP90AB1 KLHL29 [activation] FGG ICAM1 [activation] FBXO30 APC [inhibition] GRB2 SMARCD3 [activation] CCDC106 TP53 [activation] BCL2 IKBKB [activation] GOLGA2 GEM [activation] RPA3 SEH1L [activation] HDAC1 NR3C1 [activation] CDK4 ZSCAN1 [inhibition] HRAS PTPRJ [activation] MUTYH SMAD1 [activation] ITGA4 HSP90AB1 [activation] SRSF5 MAPK6 [activation] IL15 TRAF3 [activation] ITGA4 TLN1 [activation] APC SPTBN2 [inhibition] CDK4 RFC4 [activation] DIRAS3 KRAS [activation] USF1 NFYA [activation] KIT BCAR3 [activation] VCAM1 DHX16 [activation] PUM1 SAV1 [activation] EIF2B2 MRFAP1L1 [activation] NECAP1 JUN [activation] HSP90AA1 PRKCZ [activation] RPA3 PKP3 [activation] TRAPPC11 TRAPPC8 [activation] PTPN6 CD37 [activation;inhibition] HP1BP3 BARD1 [activation] ACTB ATP13A2 [activation] HSPA6 MLF2 [activation] MALSU1 ICT1 [activation] SATB1 PYHIN1 [activation] GEM CTSL [activation] DYRK1A YWHAG [activation] SEPT9 STK11 [activation] SETDB1 AKT2 [activation] DAPK3 ULK1 [inhibition] CFTR GRN [activation] HDAC4 CAMK2D [activation] TNFRSF4 TRAF1 [activation] STX17 STK11 [activation] NSMCE4A HSPB1 [activation] SLC20A1 RAPGEF1 [activation] TRIB1 CEBPB [activation] BMP10 SERINC3 [activation] FOS SMAD3 [activation] PLK1 DCTPP1 [activation] UBA5 UFC1 [activation] MYL12A MDC1 [activation] STX17 AURKA [activation] CRKL LTBP4 [activation] ADNP PLCG1 [activation] SPP1 LRRC4 [activation] BZW2 BZW1 [activation] MBL2 MASP2 [activation] CEP164 DVL3 [activation] MAL LYN [activation] DLAT MDM2 [activation] 页 157 共 454


2016/4/8 19:14

EIF2B5 CSNK2A2 [activation] USP18 IFNAR2 [activation] ARRB1 CYTH2 [activation] CSNK2B CDC25B [activation] PRKCH FYN [activation] MAST2 MXRA7 [activation] CCNC FOXP2 [activation] CSNK1D PPP1R14A [activation] JUP PTPRF [inhibition] PIK3R1 GABRA3 [activation] EGFR STAP2 [activation] MAP2K6 FBXO31 [activation] C11orf84 EGFR [activation] KAT2B CCND1 [activation] CBL EPHB6 [activation] KAT2B RPS6KB1 [activation] RAF1 NXF1 [activation] NCK1 PFN1 [activation] SP1 MEF2D [activation] BAD CREB3L3 [inhibition] STRN PPP2R1A [inhibition] GNG12 GNB1 [activation] PTK2B FGFR2 [activation] BMPR2 NBEA [activation] SUMO1 GCN1L1 [activation] CDH18 CDH12 [activation] CBL IQGAP1 [inhibition] NXF1 MCM4 [activation] PTPN6 CD33 [activation;inhibition] CACNA1C CALM1 [activation] HIST1H2BK ICAM1 [activation] TGFBR1 GNB3 [activation] CHEK2 PPP2R5C [activation] PTP4A3 NCDN [activation] LIME1 PLCG2 [activation] SMAP A2M [inhibition] THBS1 FGA [activation] CASP7 TNFRSF1A [activation] TP53 RPL26L1 [activation] VAPB ZFYVE27 [activation] ETV5 SEZ6L2 [activation] TFG GRB2 [activation] CHD8 CASR [activation] HEMGN AURKA [activation] CTNNBIP1 CASP4 [inhibition] FBXO31 SKP1 [inhibition] SAT1 HIF1A [activation] JUNB BATF2 [activation] WWP1 RASA1 [activation] NEDD8 NUP214 [activation] RANBP2 IPO5 [activation] IKBKB NAA20 [activation] ARHGAP29 RHOD [activation] ABL1 BRCA1 [activation] CSNK2A1 NCAPD2 [activation] PRKAA2 MAP3K6 [inhibition] ARHGEF6 SH3GL3 [activation] PRKG1 GAPDH [inhibition] AFF1 NSD1 [activation] DRD4 GRB2 [activation] FASLG CACNB4 [activation] ICAM1 RPL11 [activation] EPB41L3 PSEN1 [activation] OBSL1 PRDX3 [activation;inhibition] ANKRD52 PLK1 [activation;inhibition] IQGAP1 RPA2 [activation] YWHAG STK4 [activation] VCAM1 ACTR2 [activation] PTN RIT1 [activation] EGFR RIPK1 [activation] YWHAH PARD6G [activation] TWIST1 GLI3 [activation] NFATC1 PML [activation] ATG5 IGHA1 [activation] RPA1 GTF2H3 [activation] FHL2 FAM129A [activation] 页 158 共 454


2016/4/8 19:14

UBC SHH [inhibition] IRS4 MYC [activation] CSNK2A1 RELA [activation] PLCG2 PLCG1 [activation] RHOG SMAD1 [activation] HIF1A ARNTL [activation] CEBPD CREBBP [activation] STEAP3 SETD7 [activation] APC PTK2 [activation] DDX52 MYC [activation] ACTBL2 PXK [activation] APP BDNF [activation] TGFBR1 ARL4D [activation] CASP6 PIN1 [activation] CD4 MME [activation] TP53 SETD1A [activation] CREB3 CTSW [activation] ANXA2 ITGA4 [activation] CCDC8 SLIT2 [activation] RHOA KTN1 [activation] HSPA1A TRIM24 [activation] MAGED2 MYC [activation] APC ANXA7 [activation] RIPK1 MAP3K8 [activation] TPD52 NXF1 [activation] CASP3 PDE5A [activation] MAVS BIRC2 [activation] ARAP1 TNFRSF10A [activation] NXF1 RPTOR [activation] PRKAA1 SND1 [inhibition] LCP2 MAP4K1 [activation] FBXO6 SKP1 [inhibition] APOE ANKH [activation] APP OTX2 [activation] TBK1 MBP [inhibition] NCK2 RHOU [activation] HOXB7 IRAK3 [inhibition] ATP1A1 TPT1 [activation] MLH1 FCGBP [activation] CCND1 PRMT5 [activation] BRD4 MED1 [activation] HSF1 SUB1 [activation] GREB1 CDKN2C [inhibition] TP53 RASGRF1 [activation] NUDC HLA-B [activation] PXN ARHGEF7 [activation] TRAF6 PPM1G [activation] LYN FASLG [activation] FAM120A DYSF [activation] SLC6A1 STX1A [activation] EPAS1 ARNTL [activation] STK4 GGCT [activation] PIK3R1 ANK3 [activation] LIMK1 PAK4 [activation;inhibition] CASP8 FYN [activation] FYN CD55 [activation] GDI1 CDC42 [activation] SMAD4 FOXO3 [inhibition] GABARAPL2 RPS6 [activation] AGTRAP NDRG4 [activation] APP SOCS3 [inhibition] VCL BCAR1 [activation] A2M IFIT5 [inhibition] EP300 GRB2 [activation] CAMK2D CREM [activation] ISL1 APP [activation] TRAF6 BIRC3 [activation] CCL5 TRIP6 [activation] SKIL HIPK1 [activation] RECQL5 PRKDC [activation] MBP NEK9 [activation] RNMTL1 ICT1 [activation] PFN2 FMNL1 [activation] STK4 CDK3 [activation] DLGAP4 EXOC4 [activation] DIABLO XIAP [activation] 页 159 共 454


2016/4/8 19:14

USP9X SMURF1 [inhibition] TP53 PRKD1 [activation] HSF1 EEF1G [activation] UBE2E3 KLHL42 [activation] PTPRC CSNK2A2 [activation] CREBBP STAT5B [activation] NOP2 PTPRJ [activation] YWHAZ CDC5L [activation] FOXO3 SMAD1 [activation;inhibition] ULK1 ATG16L1 [inhibition] DAB2IP CUL1 [inhibition] ESR2 ZBTB17 [activation] TGFBR1 NUP37 [activation] CDKN1A CDC6 [activation] BCAR3 GAB1 [activation] LIN7C HTR2C [activation] BARD1 SRSF6 [activation] DOK2 DNAJB11 [inhibition] PTPN6 SYK [activation;inhibition] FYB RASA1 [activation] CD86 MARCH8 [activation] MAP3K7 BCL10 [activation] FRS3 NTRK2 [activation] RAD17 RFC5 [activation] EP300 MCM3 [activation] RPA1 PPP2CA [activation] LRRK2 RNF219 [activation] ILK ZNF133 [activation] PRPF6 GABARAP [activation] PRKCA GABRR1 [activation] PRKCD ITGA6 [activation] PTPRJ FLT1 [activation] BARD1 UBE2W [activation] PRKACA PDE3B [activation] PPP2CA STRN4 [inhibition] RAB5A PIK3C3 [activation] RXRA PLK1 [inhibition] YAP1 DDX17 [activation] ATF2 GLUD2 [activation] EIF4A2 JAK1 [activation] CTNNB1 FANCC [activation] PLIN1 PRKACA [activation] PARP1 NCAPD2 [activation] ERBB2 CD44 [activation] FYN CSMD2 [activation] SRF RXRG [activation] PRKG1 MRVI1 [inhibition] ALK PDX1 [activation] CDC42BPB CDC42 [activation] FYN HSP90AB1 [activation] ZFYVE9 SVEP1 [activation] CDH1 RAB8B [activation] SOCS3 GAB1 [inhibition] RASA1 APP [activation] PLS3 EGFR [activation] CPE POLA2 [activation] PSMC3IP NR3C1 [activation] CRMP1 DPYSL2 [activation] EVI5 RAB11A [activation] DOK1 CBLL1 [activation] JMJD1C PPARG [activation] NOS3 DNM1 [activation] WHSC1 NOL10 [activation] ESR1 SHOC2 [activation] SORCS2 NGFR [activation;inhibition] CKAP4 MLH1 [activation] ARFGEF2 PRKAR1A [activation] PTPRC WAS [activation] RUNX1 CCND1 [activation] GJB1 SRC [activation] CFL1 MYC [activation;inhibition] DYSF SLC12A6 [activation] STOM VCAM1 [activation] XPOT RANBP2 [activation] EXOC5 CDH2 [activation] MDM2 DDX39B [activation] 页 160 共 454


2016/4/8 19:14

ARRB2 STAT1 [activation] SRPK2 CASK [activation] ICAM3 ACTB [activation] CDKN2B ARPC3 [activation] NUDCD3 SORT1 [activation] SPP1 MARCKS [activation] HIF1AN NFKBIA [activation] DVL3 SIRT1 [activation] CASP1 BIRC3 [activation] ADAM10 TGFA [activation] CHMP3 VAV2 [activation] A2M IGSF8 [inhibition] MET SH2B3 [activation] AVPR2 PRKCA [activation] MSH4 EIF3F [activation] EIF4G3 VAV2 [activation] F10 PRKAB1 [activation] INCA1 CDKN2D [inhibition] RAC1 NOSTRIN [activation] MLH1 ATF2 [activation] PPM1B ANXA1 [activation] PRKACA PFKFB1 [activation] WDR59 EP300 [activation] WDR82 TP53 [activation] SHC1 ACTA1 [activation] TTI2 PRKDC [activation] NEK9 RAN [activation] SDC2 PRKCA [activation] HSPA2 STK4 [activation] RAC1 IFNGR1 [activation] UBE2W RNF166 [activation] ASB12 FGG [activation] RYR1 PDLIM3 [inhibition] TNS3 ILK [activation] TRAF6 FAAP24 [activation] JUP CTNND1 [activation] NUDT21 SRPK1 [activation] ESR1 NFKB2 [activation] PAK1 PGM1 [activation] CSNK2B IKBKB [activation] HSPB1 TBC1D1 [activation] KRT31 SNAI1 [activation;inhibition] YWHAG HSPA8 [inhibition] CD34 CHST4 [activation] MEGF10 RANBP10 [activation] NSMAF CD40 [activation] RPS6KA1 RPS6KA2 [activation] GHR BTRC [activation] PLXNB2 HMOX2 [activation] ABL1 SP1 [activation] SMURF1 RASD2 [activation] FLNA F3 [activation] GNB2 NFATC2 [activation] MAPK3 STAT5A [activation] WDR88 NUDC [activation] PPP1CA NDP [activation] BARD1 PGAM5 [activation] RPS6KB1 CLEC3B [activation] TRUB2 ICT1 [activation] SMARCA4 RB1 [activation] HUS1 RPA1 [activation] ACACA IKBKAP [activation;inhibition] CDK4 DBNL [inhibition] CKS1B CDKN1A [activation;inhibition] GPC6 GABARAPL2 [activation] SRF CASP6 [activation] RAC3 LDHB [activation] MAPK1 ADAM17 [activation] CCZ1B NOTCH1 [activation] SORBS1 ABI1 [activation] USP11 MRE11A [activation] YWHAZ PRKD1 [activation] SHCBP1 NXF1 [activation] CSNK1A1L CEACAM3 [activation] RIMBP3C FASLG [inhibition] GSDMB SERPINA1 [inhibition] 页 161 共 454


YWHAB NCKAP1 ARL1 HLA-B ATRIP MX2 AR SRY ATP7A ATOX1 KPNB1 ADRB2 ODF3L2 EGFR RAD51 RPA2 NOTCH2NL CIITA CDK1 RIC8A GNAI2 NXF1 RAN TP53 HINFP ADAM10 FBXO6 KCNE4 KCND2 CAV1 PPP2R1A RIPK1 EP300 CDK5 MAPK10 CCDC8 SRC C2orf50 SPP1 SPP1 PRKG1 TIAM1 IGHM TGFA ERBB4 CRTC2 ITPR1 TUBA4A ZAP70 CHRM4 GPRASP1 SDCBP ULK1 DBF4B CDC7 SNCG MAPK3 PAK2 SNX9 PTGS2 COPS3 TSSC4 TRAF2 HSP90AB1 STAT3 RET YWHAZ ACTB APP CASP3 HIST1H1C RND3 YWHAZ NOTCH1 PTBP3 YWHAG ARHGEF2 TXLNA NACAP1 GRB2 NCKAP5 RPA1 PAXIP1 SREK1 SRPK3 PEBP1 TRAF6 GUCY2C GUCA2A ICT1 MRPL21 PRKACA ITCH PRKCE OPRD1 TNF GNB2L1 HIST1H4A SSX2IP PLK1 LAMA5 MEP1A PIK3AP1 GRB2 TEC BMX DVL1 SMAD2 CDC5L CTNND1 MYOG TTC25 GRB2 CTTN MAPK14 RPL22 IL13RA1 TYK2 CD40 JAK3 SLIT3 CAPN1 NCOA3 IKBKB SREBF2 TRRAP MYC ECSIT AKT1 HSPA5 EIF4A2 EIF4G1 BMX PTPN21 GRK5 TBXA2R PRKAA1 ABI1 LMNB1 RAC1 STK38 FBXO6 WISP2 IGF2 VASP ABI3 CDK5RAP3

2016/4/8 19:14

[inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] IL2RG [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation;inhibition] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] ATF2 [activation] [activation] [activation] [activation] PRKCA [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] CDK1 [activation;inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [inhibition] [activation] [activation] CDK5R1 [activation] 页 162 共 454


2016/4/8 19:14

UBE2H RNF113B [activation] DDX39B IL7R [activation] RAC1 NOS2 [activation] CALM1 TRPC3 [activation] GABRA2 MDM2 [activation] ERBB3 PIK3CA [activation] ST5 ABL1 [activation] CAMK2A DAPK2 [activation] SAV1 MOB1A [activation] C1QTNF9 LARP4B [activation] SERPINE1 UBQLN1 [inhibition] C7orf50 PRNP [activation] SUMO2 TIMP1 [activation] ARHGAP28 HSPB1 [activation] MAPK4 ATP1A1 [activation] ABL2 TRIP10 [activation] ATG5 MAP1LC3B [activation] EIF3C CD4 [activation] CASP2 CASP10 [activation] NR4A1 SERPINA4 [inhibition] PML CDK2 [activation] NCF1 GP1BB [activation] RAD21 RAN [activation] ARPC3 THNSL2 [activation] ELK3 MAPK14 [activation] SDF4 MYC [activation] STK11 MOB4 [activation] KPNA1 GRM1 [activation] GSN PXN [activation] SMARCA5 SUMO3 [inhibition] CYBB CYBA [activation] PAFAH1B1 KATNA1 [activation] CDC42EP3 SRPK1 [activation] STK4 DNAJA1 [activation] PAX6 DIAPH1 [activation] MEN1 SMAD1 [activation] SNAI1 EZH2 [activation] PAK2 FYN [activation] STAT1 GSTK1 [activation] XPO5 ARF6 [activation] TNF RIPK1 [activation] NFYB MYC [activation] CHD3 CASP6 [activation] IGHM IGKC [activation] NME2 TERF1 [activation] SMURF1 UBE2M [inhibition] ASNS ATG101 [activation] WNK1 TNS1 [activation] SH3BGRL EGFR [activation] ICK MCM7 [activation] PPP1R13B LATS1 [inhibition] FZD1 DLG2 [activation] CD44 GARS [activation] PIK3R1 IL13 [activation] TRAF6 MRPL13 [activation] HNRNPA1 H2AFX [activation] GAB1 BMX [activation] NXF1 RPUSD4 [activation] SLC25A4 TNFRSF1B [inhibition] TENC1 CSK [activation] SUMO1 FZD8 [activation] PSG2 SMAD4 [activation] MLF1 DNAJB2 [inhibition] E2F3 DDX21 [activation] UBE2D1 NBN [activation] LRP1 SHC1 [activation] KDR ITGB3 [activation] KCNK15 SFN [activation] PPP2R4 PRKCB [activation] FYN CDC37 [activation] PRNP MOG [activation] SP1 SHC1 [activation] CD247 CD48 [activation] RAC1 RCC2 [activation] HNRNPD GRB2 [activation] HPRT1 GABARAPL2 [activation] 页 163 共 454


2016/4/8 19:14

TRAIP TRAF6 [activation] TNK1 YWHAE [activation] SMC2 HIST2H2BE [activation] HOXD13 CREBBP [activation] SRC DAB2 [activation] NCL GZMA [activation] SMAD1 SUV39H1 [activation] EGF PIK3R2 [activation] GABRA1 DRD4 [activation] ERBB3 ZAP70 [activation] SKP2 ATM [activation] ATG5 RPS16 [activation] CRK TPX2 [activation] TP53 RNF20 [activation] HDAC4 CIITA [activation] STARD10 GRB2 [activation] CHD7 CTCF [activation] NUP62 IFT20 [activation] RAB2B FAM71C [activation] NOTCH3 KAT2B [activation] MLH1 ACTG2 [activation] CDC5L TANC2 [activation] EGFR GSN [activation] UBE2E2 XIAP [activation] PTPRD PTPRE [activation;inhibition] EXOC8 EXOC4 [activation] RRAGA IL7R [activation] RBM48 BID [activation] PAWR DRD2 [activation] CNTN2 NFYB [activation] HMGN3 SRPK1 [activation] GFPT1 MYC [activation] CCDC17 FGFR3 [activation] PAK1 LIMK1 [activation] FMNL3 CIAO1 [activation] CRK EGFR [activation] FGFR1 FLRT3 [activation] GABARAPL2 TGM1 [activation] JAK3 PTPRC [activation] LCK CCR5 [activation] RIPK1 CLIP3 [activation] CCNE1 MCM3 [activation] RPS6KB1 TRIB2 [activation] STK4 TGM3 [activation] MCM3 HLA-C [activation] MBP PRKCA [activation] HCK FCGR1A [activation] GRB2 UBASH3B [activation] CTSV CDKN2A [activation;inhibition] COPS5 SPP1 [activation] CCDC8 CTNNA1 [activation] NFKB1 ETS1 [activation] SMARCA2 RAN [activation] CBL STAT5B [activation] INO80 ACTB [activation] NGFR MYCN [activation] PARD6B PARD6G [activation] RANGRF RAN [activation] PRDM2 TP53 [activation] ZNF740 PRNP [activation] SLC20A1 MAPK6 [activation] EIF4B RPS6KA1 [activation] TFDP1 AXIN1 [activation] BARD1 U2AF2 [activation] GNL3 TP53 [activation] RAN TGFBR1 [activation] SPRY1 LCE2D [inhibition] RADIL CFLAR [inhibition] GRB2 APP [activation] CRKL PTPN11 [activation] ADCK1 NXF1 [activation] GH1 RANBP1 [activation] GAB3 LYN [activation] ATM EEF1E1 [activation] CRK PXN [activation] ARF6 INSR [activation] 页 164 共 454


2016/4/8 19:14

CDK6 SORBS1 [activation] HCK WAS [activation] MYO1C SMARCA5 [activation] STAT2 SMARCE1 [activation] STAG2 CDC5L [activation] EIF4A3 SCYL2 [activation] TP53 SAT1 [activation] GLRX PTPN1 [activation] MCC MAPRE1 [activation] YWHAG ITGA4 [activation] LRRK2 MSN [activation] RIPK1 CSNK1A1 [activation] BMPR1A HRAS [activation] MAPK9 SMAD2 [activation] SPP1 STK39 [activation] YWHAB SKP2 [activation] BAAT MLH1 [activation] BTK PIP4K2A [activation] RAE1 EEF2K [activation] CD79B CD79A [activation] CTR9 CNTNAP2 [activation] YWHAB DAPK1 [activation] GNAI1 GPSM3 [activation;inhibition] JPH2 CAV3 [inhibition] CIITA SMARCA4 [activation] ST13 TNFRSF14 [activation] NCOA1 ESR2 [activation] PPARA RXRB [inhibition] NFKBIA ANXA1 [activation] NCAPG2 PHLDA3 [activation] CAV3 PDGFRB [activation] PVRL2 DBN1 [activation] HLA-B SERBP1 [activation] SRC ARRB1 [activation] PFN1 OBSL1 [activation] GABRA1 PPP3CA [activation] ARHGEF7 CD244 [activation] APC KRT15 [inhibition] HNRNPA1 RPA1 [activation] FOSL1 TAB2 [activation] BAX SNCA [activation] RRAS2 TRAF3 [activation] MAP3K4 PTPN6 [activation;inhibition] HSPB1 HSPA5 [inhibition] ATR EP300 [activation] PPP2R2A PPP2CA [inhibition] DDX24 EIF4A2 [activation] LGR4 EIF4G1 [activation] FASLG SRGAP3 [activation] EIF4A1 CCDC8 [activation] DHRS12 H3F3A [activation] APP ACYP1 [activation] MAP4K4 SLC9A1 [activation] CALM1 TNFRSF1A [activation] HSP90AA1 IRS4 [activation] CSNK2A1 STMN1 [activation] CSNK1G2 DBNDD2 [inhibition] CAV1 CSK [activation] CCL26 APP [activation] BACH1 NXF1 [activation] SMARCA4 WHSC1 [activation] RAN IPO11 [activation] PRKCB PPP1CA [activation] RIPK1 TRADD [activation] YWHAB RAPGEF6 [activation] DLG4 FZD2 [activation] RAD52 POLR2A [activation] RELA PRMT5 [activation] IL18BP IL18 [activation] IFNAR1 TYK2 [activation] LCE4A RGS20 [activation;inhibition] TLN2 FOS [activation] LAG3 CENPJ [activation] CPE INS [activation] PTPN6 CSF2RB [activation;inhibition] TIMELESS CRY1 [activation] 页 165 共 454


2016/4/8 19:14

SMARCA1 PYHIN1 [activation] SIRT2 FZR1 [activation] STAT5B CENPJ [activation] CCR10 GRB2 [activation] ARPC4 ARPC5L [activation] FYN NEK8 [activation] ESD HLA-B [activation] VAV1 BLNK [activation] ETS1 RPL13A [activation] OGG1 PRKCA [activation] SRC ID4 [activation] YWHAG PYHIN1 [activation] BIRC2 RHOA [activation] STAT1 PPP2R4 [activation] UFD1L PIK3CA [activation] ACACA STK4 [activation;inhibition] EPS8L3 SRPK2 [activation] SMURF1 FBXO30 [inhibition] EGFR APOB [activation] YWHAZ EIF5B [activation] NR5A2 CTNNB1 [activation] LRRK2 RPL11 [activation] RND3 SFN [activation] STC2 PTN [activation] ASIC3 ASIC2 [activation] GRB2 RPS28 [activation] NCK2 FASLG [inhibition] OBSL1 WDR18 [inhibition] ABI1 NCF1 [activation] GDF2 BMPR2 [activation] FCGR2C FYN [activation] SMAD2 SNRNP70 [activation] SERPINB12 SERPINF2 [inhibition] APOH CDC42 [activation] IRF7 KAT2A [activation] ADAP1 DVL3 [activation] UBE2N MDM2 [activation] MEIS1 HOXA2 [activation] FBXL19 RAC3 [activation] PTPN14 CTNNA2 [activation] CTSG LRP1 [activation] PRAM1 A2M [inhibition] YWHAZ RPRD1A [activation] MAP3K4 CNTRL [activation] TTC3 AKT2 [activation] DVL2 TFDP1 [activation] CTNNA1 MDM2 [activation] ACVR1 NEK8 [activation;inhibition] H2AFX CHD1L [activation] SRPK2 MAPKAPK5 [activation] FANCL FANCA [activation] ZNF598 EIF4E2 [inhibition] DGKD IGSF21 [inhibition] ERBB2IP MPP3 [inhibition] PRKAA1 RAF1 [activation] OSBPL6 PLK1 [activation] RAB11FIP4 ARF6 [activation] TNS3 NXF1 [activation] DNAJA1 MAP3K7 [inhibition] DHX30 NXF1 [activation] TBX2 SOX2 [activation] LRRK2 MTA1 [activation] CDK2 MCM3 [activation] WFDC5 STAG2 [inhibition] PAXIP1 SRSF4 [activation] TP53 RBBP5 [activation] EZR MAPK10 [activation] RASA1 TSC1 [activation] CDC26 MYC [activation] ABI2 PRKAA2 [activation] YWHAZ TPD52L1 [activation] BLK HSP90AB1 [activation] GP1BB PTK2B [activation] RAD9A RPA1 [activation] CNTN5 MYC [inhibition] TRAF2 FAM107A [activation] 页 166 共 454


2016/4/8 19:14

IRS4 PRKCZ [activation] MCM7 NXF1 [activation] RRN3 MYO1C [activation] BAX PYCARD [inhibition] SIL1 CCND3 [inhibition] ILK SRPRB [activation] MAPK1 HSF1 [activation] GSK3B IGF2BP1 [activation] LRRK1 TIRAP [activation] HBG2 VCAM1 [activation] AGR3 TGFB1 [activation] CEBPG ATF5 [activation] VEGFA HSP90AA1 [activation] SRPK2 DBF4B [activation] PTGES3 ESR1 [activation] ACD ENO2 [activation] KCTD17 STK16 [activation] EP300 GATA5 [activation] PIK3R1 FLT3 [activation] STAT5B PDGFRA [activation] IPO5 GABARAPL2 [activation] PTK2 CXCR4 [activation] EGFR SH2D3C [activation] EPHA8 LRRK1 [activation] GCN1L1 EGFR [activation] ACTB CPNE2 [activation] DUSP3 FGF7 [activation] TRAF3 APOBEC3C [activation] PIK3CA PDE4D [activation] PRKCD TAGLN [activation] ZDHHC17 PIK3R1 [activation] DUSP10 MAPK9 [inhibition] SORBS1 SOS1 [activation] ABCE1 LRRK2 [activation] HSP90AB1 LCK [activation] NTN4 CDKN1A [activation;inhibition] TACC2 AURKC [activation] SMAD3 WEE1 [inhibition] YWHAZ CYFIP1 [inhibition] PPP1CC ENO2 [activation] RPP38 GRB2 [activation] MET SH2D2A [activation] CSMD2 PLCG1 [activation] CSNK2A1 HIF1A [activation] GNAI1 MTNR1A [activation] HIF1AN NFKB1 [activation] MAD2L1 MAD2L2 [inhibition] RPA2 CCNH [activation] ACTA1 ITPKA [activation] RASA1 YES1 [activation] ST14 APC [inhibition] APP CAMK1D [activation] NUDC MOS [activation] APP CDK5R1 [activation] CDC5L ERCC1 [activation] DUSP1 HSPA4 [inhibition] IL4R FES [activation] EIF1B MIF [activation] EIF4A2 IBTK [activation] VCAM1 YWHAE [activation] GABARAPL2 HBG1 [activation] RHOA CAV1 [activation] PRMT5 CAPN1 [activation] PPP1R12A RPA2 [activation] EGFR UCK2 [activation] TRIM29 MLH1 [activation] MCL1 BID [activation] ASPH TRDN [activation] SMARCA4 STAT1 [activation] PSEN1 PRKCZ [activation] TRAF6 PA2G4 [activation] COPS7A NFE2L2 [activation] STAU1 SRPK1 [activation] NDEL1 CCHCR1 [activation] YWHAE HSP90AB1 [activation] MAVS STAT1 [activation] 页 167 共 454


2016/4/8 19:14

PPM1A DVL3 [activation] SRPK2 AMMECR1L [activation] KLF5 EP300 [activation] NOTCH1 RIF1 [activation] PRKDC BIRC5 [activation] FOXO3 ATM [activation] CTNNB1 SMAD4 [activation] CHUK TP53 [activation] MED1 EPAS1 [activation] CYLC2 EGFR [activation] PKP4 GABARAP [activation] ARF6 CAPN1 [activation] MAPKAPK2 BAG2 [activation] YWHAQ HMGCS2 [activation] ATF2 GLS [activation] SREBF2 CASP3 [activation] RARA GADD45G [activation] PARD6B PRKCZ [activation] NCOA3 HIST3H3 [activation] IL36RN SMAD3 [activation] PLD2 CFL1 [activation] TIPRL PPP2CA [inhibition] PRKAA2 HSP90AB1 [activation] MYC ADNP [activation] CD44 CD74 [activation] EIF4EBP1 PPP2R4 [activation] RBL1 CCNA2 [inhibition] EIF4G3 USP10 [activation;inhibition] IGHA1 FCAR [activation] AATF CHEK2 [activation] BCL6 JUNB [activation] HLA-B RAB2A [activation] PCBP1 CD81 [activation] EFEMP1 NXF1 [activation] SYK GAB1 [activation] LY6D GRB2 [activation] IQGAP1 DVL2 [activation] NOTCH4 SMAD4 [activation] RASD2 RAF1 [activation] SPRY1 CACNA1A [inhibition] PIK3R2 TGFBR2 [activation] VIM HSPB1 [inhibition] PSIP1 RPA2 [activation] HP1BP3 VCAM1 [activation] BMP1 MSTN [activation] CHUK MAVS [activation] CHEK2 RAD50 [activation] ATF6B NFYC [activation] ARRB1 MAPK9 [activation] APP CHEK2 [activation] RAF1 RANBP9 [activation] PRKCB NCF1 [activation] NR3C1 EIF5B [activation] PLXNA3 CBFA2T3 [activation] CDKN1A PPFIBP1 [activation;inhibition] PAK1 PCBP1 [activation] ABI2 TRIP6 [activation] TBC1D4 CDK5RAP2 [activation] WARS2 APP [activation] CHTOP NXT1 [activation] PYCARD PSTPIP1 [inhibition] TNFRSF17 TRAF2 [activation] TSHR LHCGR [activation] SIM2 ARNT2 [activation] NFATC1 HNRNPA1 [activation] CASP8 BCL2L10 [activation] DKK1 KREMEN1 [inhibition] ARRB2 CSN2 [inhibition] CDK18 YWHAE [activation] CNOT11 CNOT10 [activation] ATR CDC6 [activation] BRCA1 AR [activation] KLK6 COL4A5 [activation] BCL9 CTNNB1 [activation] TICAM2 IRAK4 [activation] TNF FAM105B [activation] 页 168 共 454


2016/4/8 19:14

TIA1 ITGA4 [activation] NPY2R RGS12 [activation;inhibition] AVEN NXF1 [activation] TNFRSF13C TRAF1 [activation] PEA15 L1CAM [activation] NCK1 OXT [activation] KPNB1 CD4 [activation] CASP3 COPS6 [activation] IRAK3 FOLR1 [inhibition] HOMER3 IKBKB [activation] YWHAB LRFN1 [activation] HSPD1 CD4 [activation] PIGM CHEK1 [activation;inhibition] OPN1MW RANBP2 [activation] HSPB2 TGFB1I1 [activation] FYN BCL3 [activation] DISC1 SMC2 [activation] PLG LAMA1 [activation] TSPAN10 TP53 [activation] APP OSM [activation] STAT5A PPP2CA [activation] PRKACA GNA13 [activation] KRAS DDX47 [activation] DDX18 OBSL1 [activation] GAB1 MAP3K3 [activation] DVL2 GABARAP [activation] EIF4A3 HIST1H1C [activation] C6 F2 [activation] CCR10 PRRC2A [activation] TOLLIP BHLHE40 [activation] EGFR SEL1L [activation] BACH1 ANAPC5 [activation] AURKC HSP90AB1 [activation] PRKACA NXPE4 [activation] CHGB MARK3 [activation] MYC MCM4 [activation] PDGFRB BAG1 [activation] SMURF1 CDKL1 [inhibition] PLCG1 SPRY1 [activation] BCL2L2 TP53 [activation] GART PXN [activation] CASP4 SMC1A [activation] FRK PTEN [activation] TP53 HSPA5 [activation] POFUT1 DLL1 [activation] IRAK4 HIST1H1C [activation] MLH1 PIK3C2A [activation] OLFML3 SETDB1 [activation] KALRN SUMO3 [activation] DAPK3 AK3 [activation] IL18 SHMT2 [activation] GNG11 GNB1 [activation] MAPKAPK2 LIMK1 [activation] BID CASP1 [activation] HTATSF1 NOTCH1 [activation] CSF3R WSB1 [activation] CCDC8 CDK1 [activation] ABL1 YWHAG [activation] CHEK2 FAM84B [activation] CXorf57 MLH1 [activation] HSPB1 PASK [activation] C4orf17 SUV39H1 [activation] SP1 BCL6 [activation] INSR PRKCD [activation] E2F2 GIT2 [activation;inhibition] HGF ST14 [inhibition] PML BCL6 [activation] STK11 YWHAG [activation] NCOA3 ESR1 [activation] YTHDC2 HSP90AA1 [activation] APPL1 FARS2 [activation] APP KLK6 [activation] PDGFRB S1PR1 [activation] APP SLFNL1 [activation] HSP90AB1 PRKD1 [activation] RB1 PIK3R3 [activation] 页 169 共 454


2016/4/8 19:14

PHACTR2 SRC [activation] LRRK1 GRB2 [activation] GRB2 YWHAB [activation] SPSB1 TP53 [activation] KIF2A HIST3H3 [activation] UGT1A1 UGT1A3 [activation] STRN PAXIP1 [activation] EPHB6 HSP90AB1 [activation] DPPA4 GRB2 [activation] IKBKB EIF2AK2 [activation] SUMO3 RBL1 [inhibition] YWHAG CHEK1 [activation] TRAF6 EIF4E [inhibition] CLEC4G NUP214 [activation] TRABD2A MYC [activation] BCAR1 ABL1 [activation] DNM2 SRC [activation] TFAP2A TP53 [activation] MAP2K7 FBXO6 [activation] GRB2 EPS15L1 [activation] SFN CYTH2 [activation] HCK ASAP1 [activation] CDC42BPG TBK1 [activation] MCF2L RHOG [activation] ARHGDIG KXD1 [activation] TRAF6 HEATR3 [activation] KDR BMX [activation] EXOC6 MAST1 [activation] STX1A STXBP1 [activation] ID3 MYF6 [activation] GRB2 MTA1 [activation] PRR5L MTOR [activation] UBE2D3 HLA-B [activation] ISYNA1 DUSP14 [inhibition] VAPA VAMP2 [activation] CUL1 GYS1 [inhibition] HSPB1 ADPRHL2 [activation] RAPGEF2 YAP1 [activation] HDAC1 APPL1 [activation] MYL3 CASP3 [activation] TGFB2 TGFBR3 [activation] MEIS1 CRTC1 [activation] GNB2L1 IFNAR2 [activation] SUMO1 PFN1 [activation] YY1 ATF7 [activation] NOTCH1 PBRM1 [activation] EP300 ANAPC5 [activation] CPNE3 SNW1 [activation] SLC4A3 PRKCE [activation] BTRC FGD3 [activation] PTPRA GRB2 [activation] SMURF1 FLNA [inhibition] ARF6 TRIM23 [activation] APC CSNK2A1 [activation] TGFBR1 TSSK1B [inhibition] PPP2R4 IER3 [activation] ATM MAP1S [activation] EIF2S3 GH1 [activation] NCKAP1 YWHAG [inhibition] SPN CTNNB1 [activation] RXRA ARID5A [inhibition] NR1H2 PRKCA [activation] ILK LONP1 [activation] DNAJA3 FAM131C [inhibition] BLM BRIP1 [activation] ELMO1 PTGS2 [activation] DLEU1 SETDB1 [activation] C11orf57 STAC3 [activation] CCNB1 CKS1B [inhibition] MAPRE1 AURKB [activation] ITGA2B ITGB3 [activation] LTA4H ARPC3 [activation] CDK5RAP2 PRKACA [activation] PMF1 NFE2L2 [activation] NCKAP1 CYFIP1 [inhibition] CBL PTPRC [activation] 页 170 共 454


2016/4/8 19:14

RPA3 RAB14 [activation] IL7R JAK3 [inhibition] UBA5 MCM2 [activation] CDK1 MYC [activation] CTAGE5 TRAF6 [activation] POLD1 POLD4 [activation] PRKD1 SRC [activation] RPS19 MAGEB2 [activation] RAB5C APPL2 [activation] AVP OXTR [activation] KAT2B PTEN [activation] EDA EDA2R [activation] HSP90AB1 RAF1 [activation] MMP3 CCL8 [activation] OBSL1 JUP [inhibition] HDAC1 STAT2 [activation] TRIB2 CARD16 [inhibition] STK4 HSP90AA1 [activation] CPNE3 QARS [activation] SPERT PID1 [activation] RELA IER3 [activation] AHSA2 MOS [activation] APP BCL2L11 [activation] DACH1 SMAD3 [inhibition] NPHS1 YES1 [activation] LIFR FBXO6 [inhibition] ITGB1 RPA1 [activation] PPP3R2 CCND1 [activation] APP MARS2 [activation] CREB3L1 C5 [activation] GNB2L1 BCL2L11 [activation] NR3C1 TBP [activation] CYTH4 CNKSR1 [activation] FASLG ITK [activation] SMURF1 JUNB [activation] FGA SERPINF2 [activation] FANCC BMPR1A [activation] CREBBP NCOA3 [activation] EGFR BIRC3 [activation] HIF1A CREBBP [activation] NXPE3 APP [activation] MAPKAPK3 FBXW7 [activation] NRIP1 TRAF2 [activation] NOTCH2NL DNAL4 [activation] PRMT1 PPARA [activation] JUNB JDP2 [activation] YWHAZ MYL3 [inhibition] PRKCA GRIA1 [activation] CASP7 RAC1 [activation] LYN SCG3 [activation] PRKACA CSK [activation] TRIM74 HSP90AB1 [activation] TRAF6 UBA2 [activation] SNTA1 CD3E [activation] CAB39L STK11 [activation] PIK3R1 BRCA1 [activation] YWHAZ RAP1A [activation] TBC1D3F RAB5A [activation] TP53 CSNK1A1 [activation] C8orf74 SUV39H2 [activation] HEXA ABL1 [activation] HLA-A KIR3DL2 [activation] LYN AR [activation] LUC7L2 NDEL1 [activation] PTK2B PTPN11 [activation] PSKH2 HSP90AB1 [activation] PARP2 IFNA16 [activation] SDC2 NF1 [activation] DAB1 SOCS1 [inhibition] TP53 JMY [activation] TGFBR2 SCUBE3 [activation] FAS CCND3 [inhibition] HNRNPA1 IGF2BP1 [activation] PVR DYNLT1 [activation] PPIA RB1 [inhibition] CSH1 PRLR [inhibition] 页 171 共 454


2016/4/8 19:14

C7orf25 PTN [activation] PAK2 RPL32 [activation] GPI MDM2 [activation] GRB7 CPNE6 [activation] TP53 TAF5 [activation] MET VAV3 [activation] ARPC4 ARPC5 [activation] MDM2 PRPF6 [activation] VAV2 EGFR [activation] CUL4B FANCM [activation] JUP BIRC2 [activation] EPB41L3 HSPA12A [activation] RRP1 BARD1 [activation] ILK ARRB2 [activation] HLA-B CALM1 [activation] TPD52L2 MDM2 [activation] MAPK8 EGFR [activation] PAXIP1 PPP1R12A [activation] MOV10 MAPKAPK2 [activation] RGS4 GNAQ [activation] RETN A2M [inhibition] ELANE SERPINE1 [inhibition] YWHAE TGFB1 [activation] ARF1 GABARAPL1 [activation] ETV7 RPTOR [activation] GRB2 LY6G6F [activation] DDX21 JUN [activation] FRAT1 DVL1 [inhibition] CAV1 BST1 [activation] ITGA4 HMGB1 [activation] MAGEB18 TP53 [activation] PRKCB ADRBK1 [activation] YTHDC1 SRPK2 [activation] DAZAP2 CXCL12 [activation] NXF1 NOL6 [activation] RELA SOCS1 [inhibition] NUP62 NCL [activation] MAPRE1 EPB41 [activation] IFIH1 ATG12 [inhibition] CASP3 FYN [activation] PPM1D WHSC1L1 [activation] ACTG1 REL [activation] SPTBN1 PLCB1 [activation] POU1F1 ETS1 [activation] SYNPO GRB2 [activation] TTN IGHG1 [activation] ICAM1 H3F3A [activation] SRC LRP1 [activation] PPP4R1 TRAF2 [activation] HIST1H1C MDM2 [activation] CCNA1 BRCA1 [activation] HMGB1 PSEN1 [activation] TBXA2R ARRB2 [inhibition] RB1 BCR [activation] MAPK3 SCRIB [activation] TRADD NGFR [activation] NXF1 MYO6 [activation] CASP7 DCTN1 [activation] GNA15 APP [activation] RAC1 PRKCA [activation] PARP1 NOTCH1 [activation] RPAP1 ILK [activation] NXF1 SNAI2 [activation] BRCA1 CASP3 [activation] SFN TSC2 [activation] CALM1 JAK2 [activation] REPS1 HSF1 [activation] ANGPTL4 AURKA [activation] NOP16 SRPK1 [activation] NRXN2 NLGN3 [activation] NOTCH1 FRYL [activation] GNB3 CXCR5 [activation] GPR3 GNPAT [activation] BIRC2 BOLA1 [activation;inhibition] LHX4 ISL1 [activation] BARD1 NOL9 [activation] 页 172 共 454


2016/4/8 19:14

PTPN6 BTLA [activation;inhibition] ITGB4 LPAR1 [activation] CSMD1 BCL6 [activation] ASAP2 PIK3R1 [activation] LGR4 DSCAM [activation] TXNDC17 OXT [activation] RET GFRA1 [activation;inhibition] SIRT1 TSC2 [activation;inhibition] GRB2 SP1 [activation] HSPB1 AGAP5 [activation] MPP3 MCM2 [activation] AURKA SCGB3A1 [activation] ARHGEF12 LPAR2 [activation] NOS3 NOSIP [activation] OXSR1 APP [activation] PARD3 PARD6B [activation] TAF1B THAP7 [activation] GNAS CCDC8 [activation] FSCN1 PRKCA [activation] EGFR RPS15 [activation] AURKB SNW1 [activation] ATP13A2 GPR21 [activation] TNFRSF12A TNFSF12 [activation] IFNA8 APP [activation] IL13RA2 AKT1 [activation] HSPA4L TIMP2 [activation] BAMBI SEP15 [inhibition] ERBB2IP ACVR2B [inhibition] MDM4 YWHAH [activation;inhibition] OBSL1 CKAP4 [inhibition] GH1 PPP2CB [inhibition] ICAM1 RPL8 [activation] VRK3 DSG1 [activation] TP53 CXXC1 [activation] ETS1 PPME1 [activation] AKAP1 MDM2 [activation] MCC CYCS [inhibition] MYC ARHGEF2 [activation] BCL2L11 FBXW11 [activation] POLE LRRK2 [activation] SIRT1 RAD50 [activation] BAG3 MAPK11 [activation] H1F0 PRKCB [activation] MAPK10 STMN2 [activation] NFKBIA PRKCI [activation] MEGF6 CRKL [activation] BIRC3 DAB2IP [activation] PXN GRB2 [activation] ABL1 SOS2 [activation] LRRK2 EPRS [activation] OBSL1 SMARCA4 [activation] CDH6 CDH9 [activation] GMFB PRKACA [activation] PPM1A DVL1 [activation] MAP4K3 ITSN2 [activation] PXN PTEN [activation] HIST1H3A PRMT1 [activation] RFWD2 PTPN1 [activation] CNBP MAPK14 [activation] ATF2 GAPDH [activation] GPSM2 GLIS2 [inhibition] MTOR PRKDC [activation] CDK1 TP53BP1 [activation] RB1 LIN9 [inhibition] CDK1 EGFR [activation] FOXM1 SMAD3 [inhibition] PVR SLC30A2 [activation] APPL1 CMTM4 [activation] PIK3R2 ACACA [activation;inhibition] ARF6 DHX9 [activation] POLR2A ERCC4 [activation] STX17 VTI1B [activation] CREBBP NFE2 [activation] TYK2 HSP90AB1 [activation] MSH5 LRRK2 [activation] APP LIMS2 [activation] 页 173 共 454


2016/4/8 19:14

MAPK1 PACSIN3 [activation] NUMB RALBP1 [activation] TP53 HIPK1 [activation] CD2 CD2AP [activation] IRF7 TNFAIP3 [activation] MYC ACTG1 [activation] BTRC BCL2L11 [activation] GABPA EP300 [activation] PTPN6 SIGLEC10 [activation;inhibition] CTBP2 CCR5 [activation] RFC4 BRD4 [activation] DOCK8 RAC1 [activation] MAP3K2 BIRC2 [activation] MARK3 HDAC4 [activation] ITGA2 ACTA1 [activation] MYC ERC1 [activation] ENG TGFBR1 [inhibition] ARRB1 GSN [activation] EIF2AK2 IFRD1 [activation] GABARAPL1 PIK3CG [activation] YWHAZ ZNF839 [activation] LRPAP1 ETV7 [inhibition] FAM168A UBE2V1 [activation] PRKCI BAD [activation] E2F3 MYO1B [activation] CRMP1 RGL2 [activation] TRH TRHR [activation] PTP4A3 RAB3GAP2 [activation;inhibition] SHC1 ITGB3 [activation] NBN CASC3 [activation] SRPK2 RWDD2B [activation] EGFR UBA2 [activation] PLK1 GET4 [activation] PLK1 VRK3 [activation] HIF1A MAX [inhibition] GRB2 CLU [activation] USP19 CDK1 [inhibition] CBLB TNFRSF11A [activation] UBE2E3 RNF150 [activation] JAG2 GFI1B [activation] G3BP1 FYN [activation] TNFAIP3 CASP8 [activation] IKBKB STAT3 [activation] SETDB1 GUSBP1 [activation] BLK CD79A [activation] ADCY6 GNAS [activation] SFN CHEK1 [activation] TGFA SNTA1 [activation] CCL5 RELA [activation] GRB2 CHRD [inhibition] STK4 GAPDH [activation] KPNA2 ITK [activation] ITGB3 PDGFRA [activation] TAB1 PPP1R7 [inhibition] H3F3A IGSF8 [activation] GRB2 ODR4 [activation] KPNA3 HSPB1 [activation] NR3C1 CAV1 [activation] STAT5A CD247 [activation] RPS6KA2 PRKCA [activation] EIF4G2 EIF3A [activation] AKAP13 RANBP2 [activation] PTK2 EPHA2 [activation] PTPN6 SSTR2 [activation;inhibition] PRMT5 ESR2 [activation] ICT1 MRPS2 [activation] MYL12A ITGA4 [activation] CRKL CD34 [activation] CSNK2A2 PRNP [activation] CXCL1 XRCC3 [activation] TBXA2R GRK6 [activation;inhibition] TIMP1 EEF1B2 [activation] PRKACA GUSB [activation] EP300 TBP [activation] PIN1 ERBB2 [activation] RPA2 BLM [activation] 页 174 共 454


2016/4/8 19:14

SERPINE1 KLK2 [inhibition] RRP1B MAPK14 [activation] RAD50 ATRX [activation] POU3F2 PAX3 [activation] OPTN TNF [activation] PTPN1 ESR1 [activation] KPNB1 NLK [inhibition] VDAC2 CYCS [inhibition] ZNF804A SPP1 [activation] BCL2L11 BCL2 [activation] MAPK4 ACSL3 [activation;inhibition] ERF EPHB2 [activation] PAK2 ABI3 [activation] BUB1B AP4B1 [inhibition] GABARAP HNRNPA0 [activation] TTC17 BMPR1B [activation;inhibition] C1QC PTX3 [activation] ACTB GSN [activation] PTK2B SORBS1 [activation] NLGN1 DLG4 [activation] HSP90AB1 ALPK1 [activation] ETS1 SRSF11 [activation] APP IGSF10 [activation] PDZRN3 EFNB2 [activation] BCL6 LIMS3L [activation] NTM LSAMP [inhibition] RGS19 PRKCA [activation;inhibition] CRCT1 PTN [activation] GNB5 GNG13 [activation] PRKACB HSP90AA1 [activation] GSK3A PRKACA [activation;inhibition] YWHAE ZNF839 [activation] SNAP29 ITSN2 [activation] APP SOCS5 [inhibition] FBXL5 BTG1 [activation] EFNB2 PICK1 [activation] EEF1D GRB2 [activation] ISL1 ZNF511 [activation] PRMT1 HNRNPA1 [activation] DLG1 PAX6 [activation] NOS3 TXNDC11 [activation] NFKB1 PPARGC1A [activation] GABBR2 ATF4 [activation] HSPB1 SPATA7 [inhibition] PHYHIP NFE2 [activation] PCF11 WHSC1 [activation] DIXDC1 AXIN1 [activation] NOTCH1 EGFL7 [activation] IDE AR [activation] INPP4A CAPN1 [activation] ARF6 GDI2 [activation] HOXC10 NXF1 [activation] PPP1CA CDK4 [inhibition] PRNP CIRBP [activation] GLTPD1 PHF13 [activation] STAT4 JUN [activation] SMAD1 ERBB2IP [inhibition] ACTR2 TRAF6 [activation] CSNK2A1 RPS6KB1 [activation] PXN CSK [activation] ACVR1 PLEKHJ1 [activation;inhibition] SMAD2 HGS [activation] KIT LCK [activation] SRSF10 MAP1LC3A [activation] MAP3K1 SLC25A6 [activation] VCAM1 GNB1L [activation] CYLD CEP350 [inhibition] MAP2K2 NFE2L2 [activation] PDE10A CASP3 [activation] SCARB2 PLCG1 [activation] ATR IKBKG [activation] CCNO HSPB1 [activation] CDK1 HIST1H2AB [activation] CBL MST1R [activation] ITGA4 YWHAE [activation] YWHAZ ADRA2C [activation] 页 175 共 454


2016/4/8 19:14

BMPR1A BMPR2 [activation] WWTR1 YWHAE [activation] DDR2 CDH2 [activation] KEL EDN1 [activation] TP53 ZWINT [activation] BMP7 KRTAP10-7 [activation] RPA2 RAB2A [activation] SH2D1A ARHGEF6 [activation] COPB2 UBA5 [activation] NXF2 NUP214 [activation] FAM84B XRCC3 [activation] PTK6 EGFR [activation] LYN HBS1L [activation;inhibition] APP IGF1R [activation] HSPB1 ATXN10 [activation] TRIM15 EHMT1 [activation] DCN IGF2 [activation] SKIL RB1 [activation] COBL PACSIN1 [activation] FLT3 CBL [activation] BRD7 TP53 [activation] GNB2L1 PRKCB [activation] RASL10B FGFR4 [activation] BTK PIP4K2B [activation] INSR PRKCA [activation] BCL2L2 BAD [inhibition] FSTL1 FST [inhibition] CTNNB1 SOX17 [activation] TXN MYD88 [activation] MYC ATP1A1 [activation] SNRNP35 TNFSF11 [activation] ADRA1A NOS1 [activation] KIR2DS2 TYROBP [activation] TTC23L EXOC5 [inhibition] VAMP8 STAMBP [activation] MET SOCS1 [inhibition] CXCL12 ELANE [activation] SIGIRR ENO2 [activation] GOLGA2 LATS1 [inhibition] LRRK2 VPS4A [activation] CASP3 AKT1 [activation] PDLIM7 SH2B2 [activation] RAB3GAP2 SHC1 [activation] BCL6 PIAS2 [activation] RPA1 VCAM1 [activation] HPCAL1 ESR1 [activation] ATP1A1 FXYD1 [activation] CASP3 DSG3 [activation] CDH15 BOC [activation] KCNN1 GRB2 [activation] JUNB ATF4 [activation] TNIP1 SELPLG [activation] MLF2 DNAJB1 [inhibition] PECAM1 PTPN6 [activation;inhibition] OBSL1 ACTN1 [activation] GADD45B MAP3K5 [inhibition] TRAF2 ANKRD36BP1 [activation] VCAM1 SMARCA5 [activation] FBXO6 LTBP4 [inhibition] DKK3 SMAD4 [inhibition] AURKA C9orf156 [activation] MUC12 CDC42 [activation] TGFB1 ITGB6 [activation] BMX FBXO25 [activation] TP53 CCAR1 [activation] PTPRJ FANCC [activation] PPP2CA RPA2 [activation] STX17 MLH1 [activation] CYLC2 STK11 [activation] CTNNB1 NUP98 [activation] CD44 EGFR [activation] PKP3 DSG1 [activation] MST1R JAK2 [activation] RAD9A RHNO1 [activation] MAP4K1 CARD11 [activation] SRPK1 DHX9 [activation] 页 176 共 454


PTPN6 RHBDL3 KIT CDK10 CEBPB TGFB1I1 DIAPH3 CD22 ACTB CDK1 INSR AKT1 ASAP3 GBF1 EZR CISH HMCN1 ASB7 RGS20 YWHAZ H3F3A FLOT2 LMTK2 ARFGEF2 EFNB1 SUMO1 BECN1 USHBP1 FBXW7 HSPA1L PRKACA TP53BP2 GRB2 CREBBP FGFR3 PLEKHJ1 PIN1 MLH1 CCDC70 TNXB ACTN1 SEMA7A PLCG1 CSNK2A1 RGS7 PPP1CA BMPR1B IL1A ARRB2 PRKD3 NCAM1 MDK GRPR SETD7 CBL CEACAM1 PIK3R1 EGFR HEATR3 SP1 SNRK SMARCA2 ESR1 PRR20E WDFY3 CD81 RIN3 IGLC1 YWHAE PDCD5 NRIP1 PRKCA YTHDF1 CDKN2B MYBL2 EIF5B

2016/4/8 19:14

LILRB4 [activation;inhibition] EIF2AK3 [activation] SH3KBP1 [activation] ETS2 [activation] CEBPG [activation] SDC4 [activation] NXF1 [activation] SYK [activation] ERBB2 [activation] CALD1 [activation] DOK1 [activation] PRG2 [activation] CRK [activation] FBXW11 [inhibition] PIK3R1 [activation] CSF3R [inhibition] RAPGEF2 [activation] FGA [activation] TBC1D16 [activation;inhibition] LUC7L2 [activation] DNMT3L [activation] SELPLG [activation] PPP1CA [activation] PNPLA2 [activation] PICK1 [activation] TP53 [activation] WASH1 [activation] GIT2 [activation] SHC1 [activation] AIRE [activation] STMN2 [activation] RELA [activation] SHKBP1 [activation] ACTA2 [activation] C6orf47 [activation] FAM109A [activation] CDK11A [activation] ARAF [activation] HSPB1 [activation] VEGFB [activation] CD81 [activation] FYN [activation] NCK1 [activation] EIF2S2 [activation] FOS [activation] CAD [activation;inhibition] TSC22D1 [activation;inhibition] IL1RAP [activation] PTAFR [inhibition] BCL6 [activation] PRNP [activation] SDC1 [activation] GRP [activation] SMARCA4 [activation] HSPA6 [inhibition] CEACAM6 [activation] SLC9A2 [activation] TNFRSF1A [activation] MYC [activation] RELA [activation] JUN [activation] CREBBP [activation] NOP2 [activation] SELV [activation;inhibition] EEF2K [activation] SUPT16H [activation] RAB5C [activation] STK4 [activation] CDKN1B [inhibition] TP53 [activation] CTBP1 [activation] ITGB2 [activation] NXF1 [activation] MDM2 [activation;inhibition] EP300 [activation] PAXIP1 [activation] 页 177 共 454


2016/4/8 19:14

EPB41L3 SMURF1 [inhibition] CDK6 PPHLN1 [inhibition] TRAF3IP1 TRAF3 [activation] WBSCR22 FOS [activation] MAP3K5 HSPA4 [inhibition] ATG16L1 AGPS [activation] GRIA2 CACNG2 [activation] GRASP GRM5 [activation] TRAF2 LRRK2 [activation] MYO1B RPA2 [activation] RPS6KA3 HMGN2 [activation] RPA2 RAB11B [activation] MAP3K8 NFKB2 [activation] CASP3 PLA2G4B [activation] KCNA5 SRC [activation] ACTA1 RAC1 [activation] WNK1 SYT2 [activation] CCDC8 LYN [activation] LY6G5B TP53 [activation] TSC22D4 PRNP [activation] PIK3R3 ABI1 [activation] ECSIT RELA [activation] NFATC2 EGR1 [activation] MSRB3 LNX2 [activation] PRKACA PLN [inhibition] DACH1 EYA1 [activation] MYLK GRB2 [activation] NCOA3 NR1H2 [activation] TSSK3 HSP90AA1 [activation] RAB11FIP1 RAB11B [activation] ITGA4 DDX5 [activation] STX8 STX7 [activation] PRKACA C2orf88 [activation] AFAP1 PRKCZ [activation] MYC SMC4 [activation] STAT3 TSHR [activation] RAF1 JAK2 [activation] SMAD2 KAT2A [activation] STAT3 ADRB2 [activation] ANK2 TP53 [activation] MOS MYOD1 [activation] PRKDC SPI1 [inhibition] GNAO1 PTPRU [activation;inhibition] TJP1 CDH5 [activation] YWHAG CDK17 [activation] HSPB2 EIF4E [inhibition] DNAJA2 MYC [inhibition] LARP1 AURKA [activation] EGFR FBXO6 [activation] CSK ARRB1 [activation] ARHGEF7 NCKIPSD [activation] RAF1 HSPA4 [activation] CNPY2 TNIK [activation] KALRN RAC1 [activation] LIN7C KCNJ4 [activation] SH2D2A KIT [activation] KLK1 KNG1 [activation] RNH1 G3BP2 [activation] MAPK14 CCDC97 [activation] RPA2 CSNK1A1L [activation] NXF1 STK10 [activation] NRIP1 HNF4A [activation] SUMO3 CDKN1A [inhibition] CDC27 CDC5L [activation] MRFAP1L1 PIK3R2 [activation] PLD2 PLCG1 [activation] ATM NR4A1 [activation] SOS1 LAT2 [activation] EPM2A PPP1R3C [inhibition] EIF4G1 GABARAPL2 [activation] GRB2 SH2D4A [activation] YWHAZ PARD6G [activation] CACNA1A SCP2 [activation] UBE2W FANCL [activation] HIST1H3A RPS6KA5 [activation] ACVR2B SMAD7 [activation] 页 178 共 454


2016/4/8 19:14

EGR1 MDM2 [activation] MAPK1 TNFRSF1A [activation] SRRM1 SRPK2 [activation] LZTR1 EHMT1 [activation] YAP1 SMAD7 [activation] CCL25 ACKR4 [activation] RAB5C OSGEP [activation] PROC PROCR [activation] YWHAB KIAA0355 [activation] TBC1D1 UBE2E2 [activation] CRKL TENC1 [activation] UBE2N DTX1 [activation] PTPRK CSK [inhibition] BIRC2 RNF181 [activation;inhibition] TNS3 ERBB2 [activation] RAD1 RAD17 [activation] FOS APLP1 [activation] TP53 TMSB4X [activation] IL2 FOXK2 [activation;inhibition] NOTCH1 PPP6R1 [activation] ARHGAP21 ARF1 [activation] TRMT10B MEIS1 [activation] AGBL2 TP53 [activation] NSMAF VASP [activation] CREBBP EBF1 [activation] MACF1 PLXND1 [activation] CNTNAP1 FYN [activation] ITGA4 HIST2H3A [activation] MCC MAP2K2 [activation] ABL1 FAM127A [activation] POLR2B ILK [activation] NOTCH2 NOTCH1 [activation] ESR1 GADD45A [activation] RAD50 DCLRE1B [activation] POLA1 POLE [activation] LONP1 VCAM1 [activation] PAXIP1 SRPK1 [activation] ACTA1 ABL1 [activation] FLNA CAMK2G [activation] GRB2 DOCK3 [activation] TNFRSF8 TRAF1 [activation] CDK1 MCM4 [activation] SCG2 ATRIP [activation] BMPR2 DYNLT1 [activation] UBE2H RNF186 [activation] VDAC1 SNCA [inhibition] FANCA CD79A [activation] HSP90AB1 MAST2 [activation] E2F1 TP53BP1 [activation] NEB APC [inhibition] HSP90AB1 VCAM1 [activation] VPS45 PTPN1 [activation] TIRAP BTK [activation] MYO1B RIPK3 [activation] PPIAL4D SGK1 [activation] SAG RHO [activation;inhibition] SIK3 YWHAZ [activation] BTK PRKCQ [activation] XPO1 CCDC8 [activation] SORBS1 PILRA [activation] KCNH2 CAV1 [activation] MLH1 ZC3H11A [activation] GRB2 B2M [activation] TNFRSF10B FAS [inhibition] GNA13 CXCR5 [activation] RHOA FAS [activation] SSH1 CBX1 [activation] CD79B LCK [activation] SHC1 HSPA1L [activation] RAB1A CDKN1A [activation] AOPEP NRAS [activation] PPP2CA CFTR [inhibition] ABL1 DOK3 [activation] VCAM1 HBG1 [activation] NR2C1 POLD3 [activation] MC4R AGRP [activation] 页 179 共 454


2016/4/8 19:14

CDC42 LCK [activation;inhibition] MAP4K4 PPARG [activation] RPL26 ICAM1 [activation] STAM LCP2 [activation] DLAT PDHA1 [activation] ANLN CDC5L [activation] MAP3K7 DDX5 [activation] DAPK1 PPP2R2A [activation] CDKN1B PIN1 [inhibition] CSNK2A1 SPP1 [activation] RAB5A ITGB1 [activation] GRB2 MAP1LC3A [activation] HSP90AB1 FBXL18 [activation] MYC PRKAR1B [activation] SFN PARD3 [activation] CSNK2A2 HMGA2 [activation] RAD21 NCAPG [activation] CYTH2 IRS1 [activation] TP53BP2 CRK [activation] ADAMTSL2 NECAB2 [activation] FOS UBE2I [activation] BEX1 CDH1 [activation] PGAM5 PAXIP1 [activation] TPST2 CCR1 [activation] MT-CO3 SNCA [activation] AURKB GIGYF2 [activation] TP53 NOL3 [activation] ILK KHK [activation] PICK1 PVRL2 [activation] ERBB4 CRKL [activation] ESF1 FOS [activation] HIPK4 ATP1A1 [activation] TP53 XPO1 [activation] NFKBIB GIT2 [activation] ARF1 RAD52 [activation] HSP90AA1 KSR2 [activation] MMP13 ADAMTS5 [activation] PRKACB CDK5RAP2 [activation] MMP2 BACE1 [activation] RPS6KA5 HSPB1 [activation] CSNK2B CHEK1 [activation] YY1 NOTCH1 [activation] PRKACA ITPKA [activation] MYLK PRKCA [activation] SPP1 TTC1 [activation] PRKAA2 RFX6 [activation] CDH3 CTNNA1 [activation] PAK2 LIMK1 [activation] SHC1 SOS2 [activation] HSP90AB1 NTRK3 [activation] AVPR2 MAPK3 [activation] ATG5 GABARAPL1 [activation] CAMK2D CAMK2B [activation] FGF1 SRPK1 [activation] VPS35 MTNR1B [activation] HSP90AB1 ACVR1C [activation] C8A C8B [activation] HSPA4 KAT2B [activation] EGFR SNAP25 [activation] DAB2 PRKCB [activation] LPL APOC2 [activation] PSEN2 CSNK1D [activation] CENPC PTEN [activation] C6 SART3 [activation] HSPB1 SIM2 [activation] SLC25A5 PRKAA1 [inhibition] ITSN2 WAS [activation] PRKAA1 BRSK2 [inhibition] YWHAG CRTC3 [activation] HSP90AA1 RPS6KL1 [activation] AMIGO2 AMIGO1 [activation] KLK7 TGFB1 [activation] CAMK2A HSF1 [activation] LYN BLNK [activation] RHNO1 LRRK2 [activation] TRAF6 CDC42 [activation] 页 180 共 454


2016/4/8 19:14

BCAR1 YWHAE [activation] TTI1 MTOR [activation] RPA3 CTTN [activation] HSP90AA1 NTRK2 [activation] KIAA1377 POLD1 [activation] DNMT1 SETD7 [activation] ERCC1 ERCC4 [activation] EIF4G3 HSPB1 [inhibition] GRB14 EGFR [activation] HIPK2 DYRK1A [activation] FTL GRB2 [activation] AMOTL2 INADL [activation] BCAR3 APP [activation] TP53 CPNE7 [activation] ZCCHC10 DAB1 [activation] AKT2 HIST1H3A [activation] GSTK1 VCAM1 [activation] SRC FASLG [activation] TP53 PRMT1 [activation] OBSL1 HSPB1 [inhibition] ILK IGF2BP1 [activation] H2AFX VPS35 [activation] MCM3 LZTR1 [activation] RAD21 H2AFJ [activation] RAD17 MRE11A [activation] RHOBTB2 HSP90AA1 [activation] CDK5 PSEN1 [activation] LRRK1 CCL21 [activation] PPARA MAPK3 [activation] FAM65B PER1 [inhibition] HBEGF CD82 [activation] GLCCI1 DYRK1A [activation] IFNAR1 PRKACA [activation] RAB14 RPA2 [activation] CDH9 CDH7 [activation] MRPL9 EGFR [activation] SHC1 HSPA8 [activation] NFATC1 YWHAZ [activation] AURKB CEP170 [activation] LARS ESR2 [activation] PDC YWHAZ [activation] GNB2 GRB7 [activation] MT1A TP53 [activation] PFDN1 DEFA3 [inhibition] NXF1 AGRN [activation] GABARAP HSDL2 [activation] CEBPB RB1 [activation] YAP1 HSPA4 [inhibition] KIAA1377 YWHAZ [activation] MDC1 LSM12 [activation] EP300 ETS1 [activation] RAB11B OLFM2 [activation] AR EGFR [activation] BHLHE40 HDAC1 [activation] CCNE1 GSK3B [activation] MTIF2 CSNK2B [activation] ITGB4 PRKCD [activation] DNM2 PACSIN2 [activation] BRCA1 ESR1 [activation] PTK2 GSK3B [activation] KIRREL SAV1 [activation] EP300 TP53BP2 [activation] GRB2 RPL31 [activation] ITGA4 HBZ [activation] HTR1A S1PR1 [activation] SRPK2 C4orf46 [activation] ELAVL3 MAST1 [activation] CDK5RAP3 RELA [activation] CDC23 SUMO3 [activation] SRPK2 NOP2 [activation] PSD GMFG [activation] PRKAA1 PRKAB1 [inhibition] SERPINA5 THBD [inhibition] MAP2 APOE [activation] FTSJ1 TACO1 [activation] DIABLO MDM2 [activation] 页 181 共 454


2016/4/8 19:14

TUBB MAPT [activation] PRPF19 NOTCH1 [activation] PPP2CA KLHL15 [inhibition] VCAM1 MACF1 [activation] SRPK1 EPB41L4A [activation] CDKN1B TSC2 [activation;inhibition] EPHA4 HSP90AA1 [activation] ADAM22 NXF1 [activation] CEP76 PPP3CA [activation] ELN LOX [activation] BTG2 HMGN1 [activation] GPRASP1 OPRL1 [activation] PLCD1 RALA [activation] FANCF STRA13 [activation] MLH1 TXN [activation] MARCO SCGB3A1 [activation] MAX CASP5 [activation] SYK PRKCA [activation] INSRR INSR [activation] G3BP2 C3orf17 [activation] EGFR VAC14 [activation] TERT UPF1 [activation] PDPK1 ITGB3 [activation] TUB PIK3R1 [activation] TULP3 MYO18B [activation] TBP PIAS1 [inhibition] CD40 PIK3CA [activation] FGFR1 ERBB3 [activation] SOS1 CRKL [activation] CDC5L MDC1 [activation] APP SRPK1 [activation] MMP7 MBP [activation] TRAF6 TRAF7 [activation] CASP1 CEBPB [activation] PSG3 SKIL [activation] RIPPLY2 CCDC155 [activation] BCL6 PPAP2B [activation] EGFR RBM41 [activation] PEBP1 PAK2 [inhibition] CDKN1A SIPA1 [activation] FANCG FANCC [activation] KAT2A SMAD5 [activation] OTX2 ZDHHC17 [activation] ISG15 STAT1 [activation] HSP90AA1 SGK2 [activation] CDK2AP2 MRFAP1L1 [activation] HSPB11 NUP62 [activation] TP53 TNK2 [activation] PIN1 NOTCH1 [activation] CCNB1 CDKN1B [activation;inhibition] ARRB2 YWHAB [activation] CD69 S1PR1 [activation] IRAK4 HIST1H1E [activation] CXCL10 DPP8 [activation] RXRA CTCF [inhibition] CCDC90B ANXA7 [activation] SRPK1 SREK1 [activation] TGFB1I1 MAPK15 [activation] MYC ETFA [activation] SCUBE3 MMP2 [activation] CDK11B ESR1 [activation] ASAP1 PLCG1 [activation] NFATC1 UBE2I [activation] VASN TGFB1 [activation] IL36RN SSBP4 [activation] IKBKE TBK1 [inhibition] TP53 ING2 [activation] MAP2K7 DUSP22 [inhibition] CXCL16 NOTCH2NL [activation] ITSN2 MEGF10 [activation] SFN MAP3K5 [activation] FYN C6 [activation] SETD7 PRKAR1A [activation] SIVA1 ABL2 [activation] GRB2 PSTPIP2 [activation] NDP TSPAN12 [activation] 页 182 共 454


2016/4/8 19:14

HSP90AB1 TBK1 [activation] EP300 JMY [activation] NUP62 CRCT1 [activation] RANBP2 CCDC8 [activation] MAPK8 SPI1 [inhibition] BCL10 AKT1 [activation] EPB41 PRKCB [activation] RAD50 RINT1 [activation] TAB1 IRAK1 [activation;inhibition] APC CAPZA2 [inhibition] CCM2 SRPK2 [activation] FAM222B NLK [inhibition] IRAK2 IRAK1 [activation;inhibition] STAT5B SERTAD1 [activation] GABARAPL2 HIST1H4A [activation] ITGB3 GULP1 [activation] PGRMC1 TIMP2 [activation] AURKB PPM1B [activation] CD4 MAPK14 [activation] DLL1 PSEN1 [activation] TUBB CHUK [activation] PTK7 CTNNB1 [activation] DAB1 KRTAP8-1 [activation] TNIK DSTN [activation] NRAS C9orf156 [activation] PPP2CA MAPT [activation] CYBRD1 STX4 [activation] CDK11B CASP8 [activation] CDK2 UBTF [activation] UBTF PIK3CA [activation] IKBKE DNAJB1 [inhibition] RLN2 RXFP1 [activation] ARPC4 UBE2Q2 [activation] FZR1 CDC23 [activation] KPNA1 CRADD [activation] GCN1L1 TNFRSF1A [activation] RAE1 DDX24 [activation] BAZ2A PYHIN1 [activation] CSK INSR [activation] C1orf94 DAB1 [activation] CAPN2 BID [activation] PIK3R2 PIK3R3 [activation] SDC2 CSF2 [activation] CDK16 YWHAZ [activation] SEMA4C DLG2 [activation] NFYA BRCA1 [activation] HSPB1 MAGED1 [activation] ARHGEF12 ABCA1 [activation] ESR2 TXNRD1 [activation] CDC5L CHEK1 [activation] BAZ1B SMARCA4 [activation] SSBP1 GRB2 [activation] CCNB1 TSC1 [activation;inhibition] SRPK2 WDR5 [activation] CHUK MAP3K14 [activation] TNFSF13 TNFRSF1A [activation] ILK ZNF205 [activation] TNIK SLC9A1 [activation] EEF2 IRAK1 [activation;inhibition] ZMAT2 AMH [activation] ETV6 CRKL [activation] MAPK7 ZBED6CL [activation] RANBP2 STK4 [activation] ANAPC2 EP300 [activation] PPA1 RB1 [activation] PRKCE ATF2 [activation] CD81 SHC1 [activation] RASA1 PDE6D [activation] H2AFX BARD1 [activation] EGFR ATP2B1 [activation] RHOA MARK2 [activation] DVL1P1 PTK2 [activation] AKT3 PLEKHO1 [activation] LRIF1 RAP1B [activation] ARHGAP31 ITSN1 [activation] GYG2 GYS1 [inhibition] 页 183 共 454


PFN1 CBLB AURKA PPIG ADRA1B ABCF2 STAT5A MYC BUB1 FAM124A ROCK1 MYC PAXIP1 CDKN1A PIK3R2 PRKDC SMAD1 FYN JUN EGFR NXF1 ITGA4 ANK1 IKBKB TNFSF11 GADD45G FZR1 EGFR CHGB PSEN1 PTCD1 HIF1A SRPK3 NCK1 EZH2 CUL3 MAP4K4 GNAI3 MLH1 MCM3 ITGAL VCAM1 IL1RAP RPS6KA2 PRKCA RPA2 KIF5A FYN JUN ARNTL FKBP1A POLA1 HOXA1 NXF1 OGT NXF1 CIT ANXA7 MEN1 FCER1A GRB2 LRRK2 ANAPC16 YWHAZ WASF1 PPP2R5C MDM2 ERBB2 SRC NUP160 KCNA4 BMP15 RAD17 GPR45 APC ENPEP

2016/4/8 19:14

VASP [activation] ABI1 [inhibition] DAB2 [activation] FOS [activation] STAT1 [activation] EGFR [activation] CCR5 [activation] IL1B [activation] TMEFF1 [activation] SRPK1 [activation] CRMP1 [activation] AHNAK [activation] G3BP1 [activation] CPNE6 [activation;inhibition] AR [activation] NOS2 [activation] KAT2B [activation] TNK2 [activation] PPP2R2B [activation] PPP2CB [activation] HEATR2 [activation] CSNK2B [activation] KCTD6 [activation] CDC40 [activation] NFKB1 [activation] PPARA [activation] CLSPN [activation] PTPRB [activation] TWF2 [activation] GSK3B [inhibition] ICT1 [activation] MTA1 [activation] MAPK12 [activation] BCAR1 [activation] ATF2 [activation] CCND1 [inhibition] DOK1 [activation] RIPK3 [inhibition] ACTG1 [activation] CDC5L [activation] PTPRC [activation] GRB2 [activation] CCNI [activation] L1CAM [activation] GRM5 [activation] CLSPN [activation] RAPGEF2 [activation] FOXF2 [activation;inhibition] EPAS1 [activation] CREBBP [activation] ACVR1B [inhibition] HELB [activation] PRNP [activation] TNFAIP3 [activation] NFATC1 [activation] AASDHPPT [activation] RHOC [activation] PAX8 [activation] IQGAP1 [activation] SYK [activation] LAT2 [activation] MYL12B [activation] CDC26 [activation] KIAA0930 [activation] GRB2 [activation] MAPK1 [activation] JAK1 [activation] TLN1 [activation] CBLB [activation] LRRK2 [activation] KCNA3 [activation] GDF9 [activation] POLE2 [activation] GRB2 [activation] EIF3A [activation] CCK [activation] 页 184 共 454


2016/4/8 19:14

MYC MAST4 [activation] HSPA1A BAG1 [inhibition] PRMT1 NCOA2 [activation] FXYD3 NR4A1 [inhibition] FLI1 PIAS2 [inhibition] CYCS GH1 [inhibition] HAX1 IL1A [activation] GABARAPL2 YARS [activation] NEK1 MRE11A [activation] AKT2 ARRB2 [inhibition] NGFR MAG [activation;inhibition] RHOA NCL [activation] DNAJC12 APP [inhibition] MTA2 EHMT2 [activation] LMNA LRRK2 [activation] CREBBP ESR2 [activation] PRPSAP1 PTP4A3 [inhibition] HSPA8 RIPK3 [inhibition] TP53 CHEK2 [activation] GTDC1 APP [activation] PTPN6 PILRB [activation;inhibition] RAB4A TP53 [activation] RPA2 SMC4 [activation] SMO ARRB1 [inhibition] RPL10 GRB2 [activation] ACTB HMMR [activation] GEM CLDN15 [activation] TRAF1 CASP3 [activation] APEX1 HMGA2 [activation] MTNR1B GNB1 [activation] BCL2L1 BNIP3L [activation] CD2BP2 EIF4A2 [activation] HIST1H2BM H2AFX [activation] VCAM1 RAB10 [activation] RPS6KA4 SH3KBP1 [activation] TGFBR1 BMPR1B [activation;inhibition] YTHDF1 ITSN2 [activation] OR5A1 SRPK2 [activation] NOTCH2 IL13RA2 [activation] STK4 CTNNB1 [activation] CAMK2D EIF4B [activation] ITGA4 GSTK1 [activation] UBE2I CAPN2 [activation] ADRB2 ITCH [activation] SRPK2 RPL39L [activation] NXF1 EFNA4 [activation] PRKRA SNX5 [activation] POMGNT1 IL8 [activation] CYB5B APP [activation] BCL6 TRAF3IP3 [activation] RABEP1 EEA1 [activation] CXCL14 TEX11 [activation] GNB5 GNGT1 [activation] ERH TP53 [activation] MYC HIST1H2BM [activation] ACACA PHKG2 [activation;inhibition] RAN AR [activation] ELANE SDC1 [activation] BRCA2 TP53 [activation] STK11 D2HGDH [activation] FYN PLAUR [activation] CD2 CD247 [activation] SKIL TFPI2 [inhibition] SRPK1 HDGF [activation] CREBBP CDH2 [activation] YAP1 CTNNA1 [activation] KLK6 CSN1S1 [activation] NCK1 FYB [activation] CUL4B ENO2 [activation] DDX5 TYK2 [activation] SMURF1 CMBL [inhibition] LIF LIFR [activation] GPRIN2 YWHAE [activation] ABL1 SHB [activation] MMP7 SERPINA1 [inhibition] SDC4 MDK [activation] 页 185 共 454


ATF2 BACH1 NFATC1 KAT2B MAP2K4 MAP3K14 NOTCH2NL OBSL1 DDX39B BUB1 MSANTD3 RNF11 RIPK1 IGFBP5 F2 MAP2K1 CDKN2A IFNAR1 PRMT1 DLX2 GRN CREBBP HNF4A GNPTG SRPK1 ESR2 CTNNB1 MSTN FURIN FOSL1 ATF3 KCNE1 KCNQ1 CARM1 SRC ESR1 SKIL LRP1 C3 PIAS1 CREBBP MLH1 MAP2K6 SERF1A SRPK2 NOTCH2NL DNAJB5 SMAD3 CDKN1B ABL1 NABP2 EP300 NOTCH1 CDC27 MC4R ASIP CAV1 BMX MTOR GNB2 RGS20 GLRX3 CDKN1A RNF126 HABP4 TP53 YWHAZ EIF4A1 EPHA8 AK4 FASLG KALRN CCDC8 RAB5C CDK2AP1 CDK2 RAC1 MAP3K11 FER CDC37 ACTB EIF4A3 ARPC3 OBSL1 SRC FGFR1 IRS1 ERBB2 ETS1 GATA3 ELF2 RUNX1 BCAP31 ATF2 NME3 PHLDA3 CTBP2 PLCB1 CTGF TGFB2 BCL2A1 BAX SEMA4C PNMA1 CDK1 TOP2A EGFR GRB7 RXRA PIK3R1 BTK GP6 TP53 FBXO4 GRB2 ACTG2 STAP1 TEC PTCH1 CCNB1 IL2RB PTPN6 FGFR2 LRRK1 BTBD6 PAXIP1 ACTR3 ACTB E2F1 EP300 MYC PALD1 CREG1 RB1 KCNK18 TGFBR1 RGL4 RALA SIAH1 INHA RPA3 EIF2S2 MDM2 MED1 IL6 PTHLH PTPRB NTRK1 COL4A1 MAG

2016/4/8 19:14

[activation] [activation] [activation] PID1 [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] ICAM4 [activation] [inhibition] [activation;inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation;inhibition] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] 页 186 共 454


2016/4/8 19:14

GABARAP HSP90AB1 [activation] NCKAP1 GAS7 [inhibition] RPS6KA5 YWHAZ [activation] ASPSCR1 NOTCH2NL [activation] CCND1 BRINP1 [inhibition] WNK1 CGNL1 [activation] CAMK2A ACTN4 [activation] HSPA1L TNFRSF1A [activation] TADA2A TP53 [activation] RIPK1 MAP3K3 [activation] CREB1 TP53 [activation] MFN1 MAVS [activation] LINC00341 LUC7L2 [activation] STAT3 STAT5B [activation] ADAM10 SUMO1 [activation] ITGA4 GCN1L1 [activation] DVL2 ITCH [activation] LRRK2 TTK [activation] IL7R EIF2AK2 [inhibition] SFN PPP1R3D [activation] PAK1 SHC1 [activation] YWHAB LRFN4 [activation] PPP2R5A TLX1 [activation] YWHAG MLLT4 [activation] TRAF6 KIAA1551 [activation] RACGAP1 MAP3K4 [activation] FAM83G SMAD3 [inhibition] FKBP5 ILK [activation] THRSP PALB2 [activation] GIPC1 NTRK2 [activation] SMAD1 RAB6B [activation] MAP4K3 GRB2 [activation] IL1RL1 IRAK4 [activation] CBL RET [activation;inhibition] ACKR4 CDK2 [activation] WAS NCKIPSD [activation] IGSF8 CFL1 [activation;inhibition] PLG MMP7 [activation] PPAP2C NOTCH2NL [activation] SRC SRCIN1 [activation] AGGF1 TNFSF12 [activation] RAD17 USP20 [activation] LATS1 ZYX [inhibition] HSP90AB1 OBSL1 [activation] TGFBR1 ACVR1 [activation;inhibition] UBE2W RNF165 [activation] MDM2 CLSTN1 [activation] E2F3 CTNNB1 [activation;inhibition] BCL3 HDAC1 [activation] PTP4A3 CCAR2 [inhibition] TP53 WDR33 [activation] RDX TSC1 [inhibition] TRAF6 JAK2 [activation] RPS9 ICAM1 [activation] TRIP10 FASLG [activation] TRAF3 SEC16A [activation] PPP3CA PHLPP2 [activation] SRSF3 SRPK3 [activation] PPFIA2 PPP2CA [inhibition] CD247 HSP90AB1 [activation] EP300 CASK [activation] LIN37 PDAP1 [inhibition] RPA3 RPA2 [activation] CDKN2B TGFB1I1 [activation] SGTA TGFA [activation] KCNE4 PRKCA [activation] PIK3R1 ARHGAP1 [activation] STAT3 RPS6KA5 [activation] RAC1 SUMO1 [activation] RPP14 A2M [inhibition] TBXA2R PRDX4 [inhibition] EGFR SSR1 [activation] TDGF1 COPS6 [activation] ERCC6L RPA3 [activation] RIOK3 CALM1 [activation] TFAP2B CITED2 [activation] 页 187 共 454


2016/4/8 19:14

EHMT2 SETDB1 [activation] HSPA8 TCAP [inhibition] LRRK2 RPL14 [activation] MAP4K1 PPP4C [inhibition] CASP3 GOLGA3 [activation] INSIG2 HSPA8 [activation] TACC2 KAT2B [activation] PTPRG LCK [activation;inhibition] FURIN VWF [activation] CDC42SE2 CDC42 [activation] PYCARD INPP4B [inhibition] PRKCA PRKCZ [activation] SMG1 EIF4A2 [activation] ERCC4 RAD52 [activation] SMARCA4 MYC [activation] PTPRG EPOR [activation] NRIP1 RXRA [inhibition] MYC SORBS1 [activation] BIRC3 IRF1 [activation] CASP8 RB1 [inhibition] NBN PARP1 [activation] TNIP2 MAPK1 [activation] SYNCRIP HMGA2 [activation] FZR1 BUB1B [inhibition] BAD RPS6KA2 [inhibition] GATA1 HDAC4 [activation] SMARCA1 E2F3 [activation] TP53 ASPM [activation] ADRB2 MDM2 [activation] SMAD2 NOTCH4 [activation] DVL3 LY6H [activation] NFATC1 SUMO1 [activation] PRKCD ADCY7 [activation] ARHGEF10L ANXA9 [activation] MDM2 DAPK1 [activation] HSPA8 PROP1 [inhibition] LATS1 NUAK1 [inhibition] GNAI3 TRAF6 [activation] UBA5 ALDH2 [activation] FOS TAF1 [activation] ELAVL1 YPEL5 [activation] JUN HNRNPM [activation] RRAD PRKCA [activation] MET TEC [activation] STK4 SPATA5L1 [activation] ACVR2B SMAD2 [activation] GSK3B NFKB1 [activation;inhibition] VAV2 MARCH7 [activation] AR WHSC1 [activation] GCN1L1 SNW1 [activation] HIST1H2BN ICAM1 [activation] RRAS2 ARAF [activation] HDAC4 STAT1 [activation] ATP1B3 PAXIP1 [activation] LGALS1 CD2 [activation] FGFR2 FGF3 [activation] PLK1 APP [activation] TRAF2 SOX9 [activation] RAP2B RAPGEF5 [activation] PPM1B NOS2 [activation] TGFB1I1 CSK [activation] ARFIP2 RAC2 [activation] C3 CTSG [activation] RGS17 LCE3C [activation;inhibition] ITK SOCS1 [inhibition] ENO1 MAP3K7 [activation] SGK1 SF3B2 [activation] WNK2 WNK1 [activation] EPHB6 MLLT4 [activation] BNIPL BCL2L1 [activation] CTBP1 FOXP2 [activation] PPP3CA MYOZ3 [activation] GTF2H1 PLCG1 [activation] VTN GEM [activation] KCNJ4 PRKCD [activation] CREBBP TRIM28 [activation] 页 188 共 454


2016/4/8 19:14

MPP4 FASLG [inhibition] PRKACA KLF1 [activation] KCNA4 KCNA2 [activation] ACTB SSH3 [activation] APP CNTN4 [activation] CRB3 INADL [activation] CTBP1 APC [activation] NME1 RAC1 [activation] IKBKB DUSP1 [activation] COX6A2 POT1 [activation] DAB2IP MAP3K5 [inhibition] FOXO1 HOXA10 [activation] RPS6KA5 CEBPB [activation] YWHAZ VCL [activation] CDK5R1 CTNNB1 [activation] CASP8 BEX1 [activation] GNA11 CXCR5 [activation] ABL1 KIT [activation] CDKN2C PPP2CA [inhibition] RAC1 METAP2 [activation] RASGEF1C TNK2 [activation] RAB8A RPA1 [activation] RUSC2 EGFR [activation] NFATC2 KPNB1 [activation] PDCD11 RELA [activation] MSANTD3 PFN2 [activation] APP PI4K2A [activation] NR0B1 ESR1 [activation] NFKB1 SLC25A6 [activation] PIK3R1 RRAS [activation] NCOR2 NR1D1 [inhibition] EIF3A ETS1 [activation] SMURF1 SMAD3 [inhibition] CFTR BCR [activation] JUP WWTR1 [activation] PTPRC JAK1 [activation] SKP2 NXF1 [activation] GRB2 HNRNPA2B1 [activation] E2F1 GTF2H1 [activation] RASGRF1 PLK1 [activation] MCM10 CDKN1A [activation] PLD2 PIP5K1A [activation] HTR1A HTR1B [activation] RAC1 NOXA1 [activation] NBN SKP2 [activation] IGHM CEP72 [activation] EPOR GRAP [activation] RRAS2 RAF1 [activation] FOXP1 LRRK1 [activation] YWHAE SLC25A6 [activation] CDH2 PTPN7 [activation] SRF OGT [activation] AKT1 FANCA [activation] HDAC1 NFE2L2 [activation] TRAF2 RHEBL1 [activation] RNF5 INSIG2 [activation] MEGF10 VWA8 [activation] RPS8 GRB2 [activation] RAPGEF2 WWOX [activation] BARD1 PCBP2 [activation] PTK6 KIT [activation] NUP62 CCDC53 [activation] DVL3 NXF1 [activation] HYOU1 YAP1 [activation] PTPRC PPFIBP2 [activation] PYCARD RIPK1 [inhibition] PLG ANXA2 [activation] NXF1 FAM212B [activation] AGTR1 MAPK1 [activation] EIF2S3 SNW1 [activation] PARD3B SMAD4 [activation] ILK STK4 [activation] MDM2 SFN [activation] TRAF2 NGFRAP1 [activation] TRIM24 PPARG [activation] CDK4 CDC6 [activation] 页 189 共 454


2016/4/8 19:14

ANAPC2 GRIA1 [activation] CXCL12 CD4 [activation] ZNF311 GRB2 [activation] TRIM43 MYOG [activation] MAST3 PRKAA2 [inhibition] WASL PACSIN2 [activation] PML PIAS2 [inhibition] HRAS RGL1 [activation] MAGI3 TGFA [activation] ANAPC11 CAPN11 [activation] NFKB1 COMMD3 [activation] VIM AKT2 [inhibition] CD9 KIT [activation] ENG ACVR2A [inhibition] SFN PPFIBP1 [activation] RIT1 RGL1 [activation] GNAO1 GNAI1 [activation;inhibition] PBX1 MYOD1 [activation] NFE2L2 SUMO1 [activation] EIF4EBP1 RHEBL1 [activation] TPD52 SRPK2 [activation] CDK4 SUMO3 [inhibition] HMGB1 NR3C1 [activation] TP53 GNB2 [activation] GGCX F9 [activation] TP53 KHDRBS1 [activation] CREBBP ETS2 [activation] LIN52 LIN37 [inhibition] NCOA1 RXRA [inhibition] NEK3 VAV1 [activation] FHL1 PRNP [activation] ASPSCR1 EZH2 [activation] SAMD3 C6orf165 [activation] CCDC102B C20orf195 [activation] CASP8 TRAF2 [activation] GRB2 POLR1D [activation] FOXO3 PPP2R1A [inhibition] LCK PTPRZ1 [activation;inhibition] CIT MYL12A [activation] RHOBTB2 ERBB2 [activation] TPX2 PIK3R1 [activation] TNFSF10 TRAF2 [activation] PIK3CA STAT1 [activation] NCAM1 NCAN [activation] BCAR1 EGFR [activation] FERMT2 CTNNB1 [activation] PPP6R2 NUDC [activation] DPYSL2 ROCK1 [activation] PIN1 RPS6KB1 [activation] TRIM28 CEBPB [activation] BRD2 E2F1 [activation] EFS NPAS2 [activation] SHC1 MAP4K1 [activation] ESYT1 MDM2 [activation] ATR H2AFX [activation] SRC CTSV [activation] TBK1 BTRC [inhibition] FLNA CCNB1 [inhibition] STRA13 RPA2 [activation] NUP62 NUP214 [activation] TOP2A VCAM1 [activation] PIP5K1C CDK5 [activation] ERBB3 CRK [activation] SMAD2 MFN2 [activation] NMI STAT5A [activation] JAK1 TEC [activation] RUNX1 NOTCH1 [activation] CTCF ZMYM4 [activation] CDC14A PLK1 [activation] TNFRSF9 TRAF5 [activation] SIPA1L3 MYC [activation] RAB10 PTBP3 [activation] GSK3B PPP1CC [inhibition] DLGAP3 FYN [activation] SNAP29 STX3 [activation] ISG15 RGS3 [activation;inhibition] 页 190 共 454


2016/4/8 19:14

FLNC PLCG1 [activation] RYR1 PPP1CA [activation] GHR CRK [activation] HDAC1 BAZ2A [activation] PIK3R1 ERBB2 [activation] CRHR2 UCN2 [activation] SRSF10 WWOX [activation] CCDC120 USHBP1 [activation] HLA-B TFRC [activation] GABARAP DDX17 [activation] TRAF6 NR2C2 [activation] CDC5L HSP90AB1 [activation] KAT2A KAT2B [activation] MTPN CAPZB [activation] MEOX2 PKIG [inhibition] CDK7 CDK11B [activation] CTNNBIP1 USHBP1 [inhibition] PPARGC1A SUMO1 [activation] HOXD10 PBX1 [activation] EIF4ENIF1 AURKB [activation] RHEBL1 SMAD4 [activation] BMPR2 MAPK8 [activation] KPNB1 ERBB2 [activation] CCL5 PHB [activation] TNFSF13 FAS [activation] RAD21 STAG1 [activation] ATP9A COPS6 [activation] PRKCQ CBL [activation] ACTB STX4 [activation] PREPL NR4A1 [inhibition] AURKB EP300 [activation] CCDC155 FIS1 [activation] GRB2 DNM2 [activation] CDH1 CSNK2A1 [activation] WASL RHOQ [activation] DNAJC5 VAMP7 [activation] E2F1 PRDM2 [activation] JAK1 HIST3H3 [activation] KLRK1 MICB [activation] SYK CD4 [activation] ETS1 RFWD2 [activation] MIF DSTYK [activation] ITSN1 PIK3R1 [activation] NLRP1 PYCARD [inhibition] NOXA1 YWHAZ [activation] NR1I3 RXRA [inhibition] ITPRIP RASSF1 [inhibition] PIK3R2 SOS1 [activation] PRKCZ RPS6KB1 [activation] RNF4 SRPK2 [activation] CENPC UBTF [activation] TSC1 EIF3F [activation;inhibition] TULP4 PIK3R1 [activation] CASP8 KLK5 [inhibition] YBEY GEM [activation] CDC5L GRB14 [activation] HPS6 EP300 [activation] IRS1 YWHAG [activation] PHF20L1 CASP10 [activation] IRS1 FER [activation;inhibition] MIEF2 AGTRAP [activation] EPS8L2 CD3E [activation] CCR5 CST9L [activation] ACVR2A TCTEX1D4 [activation] DDX56 RPL26 [activation] UBE2I SREBF2 [activation] SHC1 DUSP23 [activation] GRN YY1 [activation] BANP NFKB1 [activation] MEPCE CDK11B [activation] APC MACF1 [activation] SMURF1 PPM1A [inhibition] ESR1 BARD1 [activation] LAMTOR4 RRAGA [activation] FOS BTBD10 [activation] ARHGDIA BID [activation] 页 191 共 454


2016/4/8 19:14

RND2 PLXNB1 [activation] CTNNA3 CTNNB1 [activation] KLHL32 HSP90AB1 [activation] CEACAM1 ADRB2 [activation] IRF4 TRAF2 [activation] ELSPBP1 MYF6 [activation] RBX1 DAB2IP [inhibition] CENPE MAPK1 [activation] PTBP1 SRPK2 [activation] CDH10 PTN [activation] EIF4E2 AMOTL2 [activation] TERT SMARCC2 [activation] BCLAF1 BCL2L1 [activation] RAPGEF2 PRKCI [activation] PARP10 CASP6 [activation] FYN GAD1 [activation] EGFR HIST1H1E [activation] CD4 IL16 [activation] RRN3 NMI [activation] TSC1 NGFRAP1 [inhibition] TSSK3 GP2 [activation] CCNB1 RPTOR [activation;inhibition] LIG3 PLCG1 [activation] CDC42 CASP7 [activation] TNFRSF14 P4HB [activation] RPA3 EMG1 [activation] APP ARPP19 [activation] PRNP APOE [activation] ATR TTI1 [activation] GSN PTPN12 [activation] CLIP3 FADD [activation] ARPC3 ARPC2 [activation] CTNNB1 ZFYVE9 [activation] CDH7 FGF21 [activation] CCND2 RB1 [activation;inhibition] IL1RAP IL1R2 [activation] CNTNAP1 NCK1 [activation] TRDMT1 DDX24 [activation] EFHC2 CYFIP1 [inhibition] ITGB2 EGFR [activation] OLFM2 EIF1 [activation] UBE2V1 KITLG [activation] FOXO1 YWHAG [activation] CD79B ZAP70 [activation] GNAS ETS1 [activation] EGFR NCAPH2 [activation] STAU1 SRSF10 [activation] FAM49B MAPK6 [activation;inhibition] NOTCH2 MAML1 [activation] C1QTNF9 TTN [activation] PLCG1 RHOA [activation] S1PR5 TP63 [activation] YWHAZ CFL1 [activation;inhibition] ESM1 ITGAL [activation] KPNB1 PLCD1 [activation] TRAF3 MAP2K1 [activation] MEIS1 HOXD13 [activation] BMP8B BMP4 [activation] FES RASA3 [activation] DUSP6 SRPK1 [activation] FAM96B PRIM1 [activation] CTNNA1 MCM7 [activation] RNF138 LNX2 [activation] WHSC1L1 BCL7C [activation] CHL1 JUN [activation] GRB2 RPL24 [activation] AKT2 TRIB3 [inhibition] UBTF TBP [activation] SFRP2 SMAD4 [activation;inhibition] NXF1 HP1BP3 [activation] UBE2W USHBP1 [activation] CSNK1A1 BID [activation] NCOA2 DLX5 [activation] MAPKAPK2 CSNK2B [activation] PLCB3 TRPC3 [activation] CBL ACTN1 [activation] 页 192 共 454


2016/4/8 19:14

DLGAP3 PIK3R1 [activation] SNCA EEF1A1 [activation] EGFR SFN [activation] RAD51D KIFC3 [activation] CRKL SHANK3 [activation] PBK KIAA1377 [activation] JUNB DDIT3 [activation] CDC16 RB1 [activation] CDK11A PRPF40A [activation] ROCK1 IRS1 [activation] NBN RAD50 [activation] LXN CPA4 [activation] SMURF1 WEE1 [inhibition] EPB41L3 CRK [activation] MAP3K1 HSPA6 [activation] TEX33 LRRK1 [activation] RIF1 STX5 [activation] SUV39H1 KLHDC4 [activation] DHX8 NOTCH1 [activation] CDC6 CCL2 [activation] GABARAP STK3 [activation] MTERFD2 ICT1 [activation] NSF PTPRC [activation] RPS6KA3 EIF3C [activation] PPP2CA PPM1B [inhibition] HMOX2 INPP5K [activation] FBXW11 AXIN2 [inhibition] PPP1CA PPP1R3C [activation;inhibition] RAP1GDS1 HRAS [activation] YWHAB DOCK4 [activation] VDR SRPK1 [activation] CXCL11 MTUS2 [activation] TBXA2R KCNMB1 [inhibition] CD2AP HCK [activation] HSPB2 TRAF6 [activation] SIX1 EYA3 [activation] GRK6 GIT1 [activation;inhibition] DOCK11 YWHAB [activation] TTC13 FBXO6 [inhibition] RICTOR HNRNPUL1 [activation] SRPK3 PHF5A [activation] GRB2 MLXIPL [activation] TRRAP DOT1L [activation] GTF2H1 PIK3R1 [activation] EZH2 ANXA4 [activation] CASP4 HIGD1A [activation] BMP3 COL4A2 [activation] FASN HSP90AB1 [activation] TFDP1 SOCS3 [inhibition] CASP2 CSNK2A1 [activation] ACTA1 EP300 [activation] CDC20 CDC16 [inhibition] CDK5RAP2 KAT5 [activation] NUP88 CD82 [activation] ACVR1 RAB25 [activation] HIST3H3 PRKCA [activation] ESR1 SETD7 [activation] LRFN4 PPP2R1A [inhibition] VCAM1 SCRIB [activation] RPA1 RPA4 [activation] CPSF3 MDC1 [activation] SYK TRAF3 [activation] TPST1 CCR2 [activation] ADRB2 CD81 [activation] MAP1B STK3 [activation] CDH10 CDH9 [activation] SGK1 PIP [activation] NR3C1 CD4 [activation] GPR151 GAL [activation] PLAGL1 TP53 [activation] ABL1 SORBS1 [activation] SETDB1 BID [activation] XPO1 STK4 [activation] GNA15 OPRK1 [activation] CDK5RAP3 UFC1 [activation] ACTN1 BTK [activation] 页 193 共 454


2016/4/8 19:14

SIRT3 HSP90B1 [activation] GIPR GCG [activation] YWHAG DDX39B [activation] PRKAA1 MARK1 [inhibition] TRAF6 ETF1 [activation] RAC1 CDC42SE2 [activation] PAXIP1 CYB5R4 [activation] CDC5L OXSR1 [activation] NOTCH1 WDR11 [activation] ACTN1 GIT2 [activation] SRGN CCL3 [activation] AFAP1 SRC [activation] TRAF6 EDARADD [activation] POR INSIG1 [activation] MMTAG2 RASSF10 [inhibition] C8orf33 NGEF [activation] MYC RPRD2 [activation] WAS CSNK2A1 [activation] MLH1 FLNB [activation] SH2D2A ITK [activation] PSEN2 RAB11A [activation] EGFR OS9 [activation] EP300 MORF4L1 [activation] NBN RPA3 [activation] NR3C1 HMOX2 [activation] HEMGN MCM3 [activation] HIRIP3 SRPK2 [activation] NUMB EPS15L1 [activation] CDK17 NOP10 [activation] CD44 TGFBR1 [activation] TRAF6 PTGES3 [activation] BTC EGFR [activation] ESR1 BRI3BP [activation] SUMO2 ERCC4 [activation] DOCK8 E2F3 [activation;inhibition] ERG PRKDC [activation] CAV1 RASA1 [activation] FGF2 FGFBP1 [activation] AURKA BTRC [activation] CDC5L UBA5 [activation] GLRX2 TXNRD1 [activation] SRC EIF3D [activation] KIDINS220 MYC [activation] APOE LDLR [activation] NXF1 EIF4A3 [activation] C6orf165 USHBP1 [activation] STAT5B PGR [activation] CDH11 CDH2 [activation] ESYT2 MAPK15 [activation;inhibition] BATF3 ATF4 [activation] ABI1 VAV1 [activation] YWHAB SLC8A2 [activation] HSP90AB1 PRKCA [activation] FMNL2 CDC42 [activation] GRB2 SUV39H2 [activation] HLA-B SBDS [activation] CHEK2 STAT1 [activation] RHOA BID [activation] PPM1H NXF1 [activation] ADAM17 MAD2L2 [activation] SLC6A3 TGFB1I1 [activation] MAP1LC3B FAS [activation] AKT1 STAT1 [activation] CARD11 FYB [activation] PSMA2 INSIG2 [activation] HIST3H3 AHDC1 [activation] GRB2 SNX12 [activation] CDKN1A COL4A5 [activation;inhibition] FSCN1 HLA-B [activation] TNIP1 PIK3CD [activation] GNAQ FFAR2 [activation] TNFSF12 LYN [activation] ITK TGFBR1 [activation] RAPGEFL1 MLH1 [activation] CDC5L MAP2K7 [activation] RICTOR HDAC1 [activation] 页 194 共 454


2016/4/8 19:14

RASSF1 BTRC [inhibition] LRP1 HSP90AA1 [activation] PPARG PRNP [activation] HSPA12A CDC5L [activation] DGKA SIRT1 [activation] APP RIOK2 [activation] CCL19 CXCL13 [activation] SMARCB1 CEBPB [activation] STK4 ELAVL1 [activation] HSDL2 ADRB2 [activation] TICAM1 TRAF2 [activation] NOTCH1 MCM5 [activation] PHF14 PYHIN1 [activation] CBL NCK1 [activation] PAK6 HSP90AB1 [activation] PIK3CA TMOD1 [activation] JMJD1C RXRA [inhibition] CDC25C PCNA [activation] RALGDS CNKSR1 [activation] CASP1 IL1A [activation] HSPA9 TP53 [activation] MEIS2 TLX1 [activation] FYB SRC [activation] ANAPC5 ESR2 [activation] EFNA1 KAT5 [activation] NBN POLR1B [activation] CDKN1A HDAC4 [activation] CWC25 MDM2 [activation] COMMD4 RELA [activation] SMARCA5 SATB1 [activation] FGA FGG [activation] SYK PAG1 [activation] GRB2 FCGR2B [activation] CAMP CTSG [activation] NXF1 TRIM29 [activation] HIST1H1E CD81 [activation] APP CDKL3 [activation] HIF1A NR4A1 [inhibition] PLK3 PRNP [activation] MAPK1 PAK1 [activation] INHA INHBB [activation] YARS2 ICT1 [activation] FGB SERPINA5 [inhibition] PRG4 MYC [activation] TP53 JMJD6 [activation] ANKZF1 AURKB [activation] CES1 CREB3 [activation] PRKRA SRPK3 [activation] YWHAB SRSF10 [activation] ESR1 SHC1 [activation] CDK2AP2 WARS [activation] ERH ACP6 [activation;inhibition] HSP90AB1 STAT3 [activation] NCDN A2M [inhibition] HLA-C SARS [activation] AR PTPN11 [activation] ERBB2 SPTBN4 [activation] NCL ICAM1 [activation] PFN1 FMNL1 [activation] SPP1 KIAA1009 [activation] PLEKHA5 YWHAG [activation] PHLDA3 APP [activation] FLOT2 CCDC8 [inhibition] HERC5 CDKN1A [inhibition] PPP1CA PHACTR4 [activation;inhibition] BCL2 BID [activation] PAK4 RAN [activation] ICAM1 RPL18 [activation] GRB2 ARHGEF7 [activation] RAPGEF1 CBL [activation] BMX CASP3 [activation] TGFBR1 TRAP1 [activation] GSG1L LXN [activation] PLK1 MDM2 [activation] ARPC5 GRB2 [activation] RNF19A ZAK [activation] 页 195 共 454


2016/4/8 19:14

PTGS2 CASK [activation] PAK7 BAD [inhibition] ARHGEF7 SHANK2 [activation] FZD5 SCYL2 [activation] DNAJA1 YWHAE [inhibition] HNRNPAB PAK1 [activation] GRK6 LTB4R [activation] PLCG2 FLT1 [activation] NFKBIA HSPA4 [activation] COPA ITGA4 [activation] IKBKB SMARCC1 [activation] KDR FLT1 [activation] RB1 DYRK1A [activation;inhibition] MAPK8 CDKN2C [activation] PIK3R3 ORM1 [activation] SH3KBP1 CTNNB1 [activation] PDGFRB HSP90AA1 [activation] SMAD3 ATF3 [activation] CDK11B PIN1 [activation] RAPGEF2 VSIG8 [activation] AGK MYC [activation] DPY30 SMARCA1 [activation] SIRT1 MRE11A [activation] ZFYVE9 STAM2 [activation] EPHA8 FYN [activation] CPN1 C3 [activation] GRB2 GJA9 [activation] ABI2 NXF1 [activation] GADD45A MDM2 [activation] NCALD ACTB [activation] DDX58 RAI14 [activation] ATM SNW1 [activation] CTNNB1 ISG15 [activation;inhibition] CCHCR1 AMOTL2 [activation] CCL17 DARC [activation] NOS1AP NOS1 [activation] TRAF2 RBM41 [activation] HLA-B CD8A [activation] ACVR1B HSP90AB1 [activation] CASP3 UBC [activation] RAD54B MDM2 [activation] CLK4 SRPK1 [activation] TNFRSF10B RHOA [activation] RARS GRB2 [activation] MCM6 EGFR [activation] ZBTB33 CTNND1 [activation] MBP TLK1 [inhibition] ZP4 FURIN [activation] UBE2I ATF2 [activation] EIF4E2 MYOG [activation] ELK1 MAP2K1 [activation] EZR PLCB3 [activation] ODC1 MAP2K1 [activation] RAE1 SEH1L [activation] GLP1R ARFRP1 [activation] SRSF10 PAXIP1 [activation] PAK1 FOXO1 [activation] POLD3 CHD4 [activation] FTSJ3 EIF2AK2 [activation] AIP GNAQ [activation] INPP5D GRB2 [activation] TOPORS TP53 [activation] ANXA7 GAPDH [activation] GTF2B CREBBP [activation] APITD1 FAAP24 [activation] IGSF6 APP [activation] CDC6 CDK6 [activation] CDH1 SFRP2 [activation;inhibition] EP300 BCL6 [activation] STX19 SUV39H1 [activation] PSEN1 KCNIP4 [activation] CACNG1 VAPA [activation] LTB4R GNA15 [activation] GRB7 SFN [activation] IQGAP1 ISG15 [activation;inhibition] CDX2 SMARCB1 [activation] 页 196 共 454


2016/4/8 19:14

DNAJB4 SMAD3 [inhibition] SPERT CDC23 [activation] SUV420H2 RBL2 [activation] UBA5 UFM1 [activation] SRGAP2 EXOC1 [activation] PXN IQGAP1 [activation] RAC1 DOCK2 [activation] CHRM2 SET [activation] CCND3 RB1 [inhibition] RPA1 TFRC [activation] PID1 NME1 [activation] SIRPA PTPN6 [activation;inhibition] MAD2L1 APC [inhibition] FGFR2 APP [activation] E2F1 LAMTOR5 [activation] BCL10 CASP9 [activation] VCAM1 EIF4A3 [activation] PNP VCAM1 [activation] PAX1 MEOX1 [activation] MYC NOL11 [activation] SRC NR1H3 [activation] TSC2 RAB5A [activation] PRIM1 NXF1 [activation] RXRA MAPK7 [inhibition] APC CEP250 [inhibition] CCNA2 CCNB1 [activation] DTNB NUP62 [activation] PDGFA DUSP3 [activation] BCL2L1 DOCK7 [activation] STX1B UNC13B [activation] DVL2 FZD4 [activation] NCOA2 JUN [activation] CSNK2A1 CAV1 [activation] EIF3I CD4 [activation] PAK1 SNW1 [activation] PDE6H GNAO1 [activation;inhibition] MAP4K1 FBXW8 [activation] MAST2 TTN [activation] CLEC5A TYROBP [activation] PAK4 YWHAE [activation] RXRA CLOCK [inhibition] CLCA1 ITGB4 [activation] CALM1 CCNA2 [activation] PAXIP1 RNF32 [activation] DOK3 CSK [activation] MDM2 ECH1 [activation] APP FCGR3A [activation] ATAD1 GOSR1 [activation] STAT5A CRKL [activation] PTEN QRFPR [activation] IKBIP NUP62 [activation] PRKCZ ECT2 [activation] HDAC3 MAPK11 [activation] HDAC1 HSD11B2 [activation] CREBBP AIRE [activation] YWHAZ SUPT6H [activation] TIMP2 HSP90AB2P [activation] MAP3K5 YWHAB [activation] EIF2B1 ADRA2A [activation] FYN GAB3 [activation] HSP90AB1 TESK1 [activation] PRKCZ GSK3A [activation] SMCHD1 OBSL1 [inhibition] MYC IL4R [activation] CSH1 SMAD2 [inhibition] SMARCA5 RPA1 [activation] LMNA EGF [activation] BCR MAP4K5 [activation] FANCG FTSJ3 [activation] BATF2 RELA [activation] EIF2S3 HLA-B [activation] MDM2 PLEC [activation] PDIK1L TNF [activation] KCNIP3 CASP3 [activation] BCAR3 EGFR [activation] LRRK2 TPM2 [activation] 页 197 共 454


2016/4/8 19:14

RPL10L TP53 [activation] STAT5B DMRTA1 [activation] LMNB1 LRRK2 [activation] TP53 EFEMP2 [activation] FSD2 PIK3R3 [activation] ARL15 FUNDC2 [activation] RAC1 SET [activation] ARRDC4 AVPR2 [activation] TP53 EIF4E2 [activation] RIN3 GRB2 [activation] EIF3F HTR2A [activation] GAB2 LAT [activation] EGFR MON2 [activation] AGT PRCP [activation] WHSC1 HNRNPAB [activation] INSR PTPRJ [activation] FYN ARHGEF11 [activation] POLR1B GRB2 [activation] EPRS MAPK13 [activation] FLOT1 BACE1 [activation] STX5 NAPA [activation] MAPK8IP1 DUSP16 [inhibition] P2RX4 CDH5 [activation] PDIA2 FYN [activation] GATA4 EZH2 [activation] PRKCD TIAM1 [activation] MAPT PRKACA [activation] FAS TNF [activation] GRB2 TRAIP [activation] DAB2IP DAB1 [activation] PRKCE GJA1 [inhibition] CHEK2 MUS81 [activation] FGFR3 STAT1 [activation] MAPT CASP8 [activation] PTPN6 LIFR [activation;inhibition] PTPRC CD8A [activation] AR CTNNB1 [activation] RIPPLY2 TFG [activation] RAP1GAP2 WNK1 [activation] VCAM1 GOLGA7 [activation] GATA1 SMARCA4 [activation] FBXO25 MYO1B [activation] GRHPR FOS [activation] MAX EPAS1 [inhibition] TP53 ASH2L [activation] POMC HLA-DRB3 [activation] CCDC57 TBC1D22B [activation;inhibition] KIRREL NPHS2 [activation] HSP90AA1 CDK11B [activation] CD3D CD3E [activation] MCM7 USHBP1 [activation] HTR1D HTR1A [activation] GABARAPL2 SRSF5 [activation] TRAF3 TFG [activation] KAT2B ACTB [activation] FBXO6 ITGA2B [activation] TGFBR1 IKBKB [activation] CFTR GNAI2 [activation] SMAD2 ITGB4 [activation] ACTG1 FPR1 [activation] NUP50 RAN [activation] BCR PTPN6 [activation;inhibition] PCBP2 H2AFX [activation] ENPEP AGT [activation] ST8SIA2 NCAM1 [activation] SRCIN1 SNAP25 [activation] SMAD1 EIF2AK4 [activation;inhibition] FLNC WNK1 [activation] DNAJA1 DNAJA4 [inhibition] NIPSNAP1 OBSL1 [activation;inhibition] PARD6A YWHAH [activation] CRYBB2 HSPB1 [inhibition] MAPK8 PDPK1 [activation] STAT3 TIRAP [activation] ADRB2 RAB18 [activation] FOCAD RAD21 [activation] 页 198 共 454


2016/4/8 19:14

MEIS1 TLX1 [activation] MYO10 PRKCI [activation] APITD1 STRA13 [activation] YWHAB MAPK7 [activation] MYC RFC5 [activation] HPDL MDM2 [activation] GRPEL1 HLA-B [activation] MYC MLH1 [activation] SMAD3 FOXL2 [inhibition] SRC NR3C1 [activation] CPNE1 MAP2K1 [activation] FANCA LIPG [activation] PPP2R2B JUP [activation] ACTG1 BMI1 [activation] TRADD FAS [activation] SRMS DOK1 [activation] PLK1 ERCC4 [activation] MOCS2 ABCF3 [activation] ADIPOR1 NFKBIL1 [activation] TAB1 EGFR [activation] ATG3 CREBBP [activation] INS HLA-DQB1 [activation] SMAD2 ANAPC10 [activation] STRA13 FANCG [activation] SLC25A4 ICT1 [inhibition] ACTB GABARAP [activation] VAPB TTC1 [activation] BAIAP2 CDC42 [activation] BMPR2 LSP1 [activation] EPHB1 CBL [activation] CDK4 SHOX2 [activation] ESR1 CHUK [activation] LTBP1 CACNA1A [inhibition] PRKCD TOP2A [activation] SUMO1 CASP8 [activation] PLEKHB1 BMPR1B [activation] SMC4 YY1 [activation] LAMA1 APP [activation] PPP3CA CABIN1 [activation] HSP90AA1 HIST3H3 [activation] IFNAR1 PTPRC [activation] CDH2 PTPRC [activation] PRKDC YWHAG [activation] SKIL PIAS1 [inhibition] DVL1 SMAD3 [activation] CCNA1 RPA1 [activation] TAB1 SERPINA4 [inhibition] PRKCD PLSCR1 [activation] TYK2 KLF10 [activation] HSPB9 CTCF [activation] NPY NR1H2 [activation] OBSL1 RRP9 [activation] MCM3 EPAS1 [activation] M6PR REN [activation] ANAPC11 CDC27 [activation] STIP1 STK11 [activation] GSN CSK [activation] UBE2I IQGAP1 [activation] BRF2 MYO1B [activation] FABP3 ITGB4 [activation] AP2S1 EGFR [activation] KIF2A LRRK2 [activation] SHOX2 ZDHHC17 [activation] OBSL1 NUP214 [activation] MEOX2 MMP3 [activation] CTNNB1 CAV1 [activation] YWHAZ TP53 [activation] GJA3 CAV1 [activation] STAT1 SPTAN1 [activation] UBC F2R [activation] GNAZ STIP1 [activation] MDM2 TMEM87A [activation] SRPK1 APMAP [activation] RAPGEF2 SSSCA1 [activation] EPRS ITGA4 [activation] BCAR3 PPP2R1A [inhibition] 页 199 共 454


PRKDC GRB2 TGFB3 LRRK2 PPP3CA PAX3 YWHAE CTCF E2F4 WDR5 PICK1 RCVRN HDAC4 MAPK8 CSNK1D NTN4 RXRA IP6K2 TP53 PAXIP1 RAD54B PTPN18 VHL YWHAG NLRP2 CDK2 FCGR1A SARM1 IFNA1 EYA2 MYOD1 TP53 EP300 PLXNB1 CDS1 NCOR2 ANK2 PPP1CA SLC25A5 HCFC2 SLC25A6 DOCK7 FAS NLRP3 GRB2 STAT1 MAPK14 RARA DLGAP2 MIF CHEK2 CD3E RPA3 MEF2A MTNR1B PAK4 MDM2 DDX39B U2AF2 RAC2 MOS SRC PRMT1 IRS4 ETS1 NXF1 CFLAR SRC IL8 PRKCA EZH2 CKAP4 DMXL1 BCL2L1 KALRN CASP9

2016/4/8 19:14

TTI1 [activation] DTX1 [activation] LTBP3 [activation] PPP1CA [activation] CASP3 [activation] SRC [activation] CDK16 [activation] HMGB1 [activation] PML [inhibition] KMT2A [activation] GRIA4 [activation] GIT2 [inhibition] MECOM [activation] SIRT1 [activation] PTPN14 [activation] DCC [activation] TRIP10 [inhibition] TP53 [activation] ERCC2 [activation] PCBP2 [activation] TRAPPC6A [activation] GRB2 [activation] MSH4 [inhibition] MAP3K5 [activation] IKBKB [activation] PHLDA3 [activation] CRKL [activation] TRAF2 [activation] IL2 [activation] TFAP2A [activation] NUPR1 [activation] ESR1 [activation] TACC2 [activation] RHOD [activation] CDC25C [activation] GEM [activation] L1CAM [activation] STX1A [activation] TP53 [activation] FOXO3 [inhibition] MAP3K3 [activation] SNCA [activation] EGFR [activation] CARD8 [inhibition] PNRC1 [activation] FGFR4 [activation] IKBKB [activation] GNAQ [activation] NOS1 [activation] GORASP2 [activation] STRAP [activation] CCR7 [activation] PRKDC [activation] SMAD2 [activation] COPA [activation] GRB2 [activation] MIF [activation] EIF4E [activation] DVL2 [activation] FBXO6 [activation] FKBP5 [inhibition] ESRRG [activation] AR [activation] SAV1 [activation] SRC [activation] RAD51D [activation] EPPK1 [inhibition] ANXA2 [activation] CCL4 [activation] ADRBK1 [activation] SUV39H1 [activation] MAST3 [inhibition] CALM1 [activation] MTOR [activation] COIL [activation] MAP2K1 [activation] 页 200 共 454


LRRK2 WASF2 SPHK1 EP300 NRGN PRKCB LCK SKAP1 CASP10 NFKBIL1 GIT2 PAK3 CDCA8 PIAS2 PPP6C ARHGEF2 SMAD4 PLG SLC25A6 TRADD CTNNB1 AKAP12 APPBP2 ERO1L PTGDR MAPK3 GRB2 PDLIM7 CHMP4A EGFR EP300 FUS BACE1 BRI3 SERPINA1 PGR BPTF ARF6 QTRT1 COL1A1 BMP1 MAML1 CREBBP UBE2E2 UBOX5 CDK2 CDKN3 ATM ACTL6B APC SETDB1 PHIP PYHIN1 TNS1 KIT SKP1 BCL6 CTNNA1 OBSL1 TYK2 PRMT5 ALKBH1 DNAJB6 CPNE1 CPNE4 SMURF1 ETV6 FOS FIP1L1 PPP2CA CCT8 NUMB TP53 DVL3 CYLD HSP90AA1 SMAD4 PAX6 P2RX2 P2RX1 STX7 VPS11 APC MBD5 HSP90AB1 HSP90AA1 CTNNA1 CDH1 NDRG1 ACTG1 ASB16 SRC EIF4G3 CAMK1 SNCA PTK2B KLRC4 MICB CDKN2A MYC SPP1 DNTTIP2 SRPK2 C1orf63 ADCYAP1 VIPR1 PLEKHF2 TRAF6 DAB1 SIRPB1 NUDT5 GH1 EPB41L3 YWHAH CMTM5 TPD52L3 SMURF1 CDK14 RNF126 TRAF6 CPNE1 BUB3 CEBPD E2F1 ANAPC5 MDC1 MARK1 STK11 JUNB SAT1 PAK2 PGRMC1 SWAP70 RAPGEF4 PIK3R1 CD3E NAF1 DAB1 DOK1 ERBB2 RAB3GAP2 VAMP8 VCAM1 HLA-B KLRD1 RAF1 BCL6

2016/4/8 19:14

[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] PRTN3 [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [inhibition] [activation] [inhibition] MAP2K7 [activation] [activation] [activation] [activation] [inhibition] CDK11A [activation] NTRK3 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] PAXIP1 [activation] [activation] [activation] [activation] 页 201 共 454


2016/4/8 19:14

RCAN1 RAF1 [activation] TRAF5 NGFR [activation] UGDH SIRT1 [activation] RGS14 GNA11 [activation] SHB MET [activation] HIST3H3 RCOR1 [activation] RELA PRMT1 [activation] HDAC1 SMAD1 [activation] TSHR PIK3R1 [activation] WDR18 MDC1 [activation] TP53 CRYAB [activation] MSR1 MALL [activation] CDK5RAP2 CRMP1 [activation] STAT5B STAP2 [activation] IRF5 MYD88 [activation] SFN FOXO4 [activation] RAD51D XRCC2 [activation] WDR20 TYK2 [activation] YWHAB RICTOR [activation] NR2F1 NSD1 [activation] NGEF RHOB [activation] TNRC6C CNOT10 [activation] GRK6 SLC9A3R1 [activation] PRKDC NFKB2 [activation] RGS20 ABL1 [activation;inhibition] GNA13 S1PR2 [activation] ABI1 ITK [activation] SLC9A1 MAP3K7 [activation] EP300 PPP2CA [activation] NR1I2 RPS6KB1 [activation] ARL13B UBE2I [activation] PTPRC CD22 [activation] DOCK2 CDC25B [activation] HLA-B SLC1A5 [activation] NUMA1 DVL1 [activation] RHOA TGFBR1 [activation] ASB18 SLC25A6 [activation] ILK DHX36 [activation] ANAPC7 ANAPC15 [activation] SMURF1 LHX9 [inhibition] CCDC137 SRPK3 [activation] CTNND1 MTNR1B [activation] MYOZ2 MYB [activation] AHCTF1 CTNNB1 [activation] PRKACB VAPA [activation] RALGDS RIT2 [activation] DUSP4 CRMP1 [activation] TICAM1 TNFAIP3 [activation] SMAD4 PIAS2 [inhibition] SRPK2 PAK4 [activation] ARF6 SRPRB [activation] JUP PKP3 [activation] CTNNB1 SUMO1 [activation] GNB2 ERBB2 [activation] PIH1D3 P2RX4 [activation] OSBPL9 HSPB1 [activation] ANAPC7 PTEN [activation] HLA-B EIF3I [activation] NAA38 UBE2E3 [activation] NFE2L2 NFE2 [activation] PDIA4 ATF2 [activation] GNA12 ACTB [activation] CNP LRRK2 [activation] PGR EP300 [activation] CAMK2A HSP90AB1 [activation] DNM1 GRB2 [activation] TNIP3 KIF11 [activation] TJP2 TRAF6 [activation] PPIG SRPK1 [activation] PFDN1 EOMES [activation] PLCG1 AR [activation] GTPBP10 ICT1 [activation] PCNA CDK2 [activation] SRGAP2 ITSN2 [activation] RUNX1 SMAD5 [activation] CD38 PECAM1 [activation] 页 202 共 454


2016/4/8 19:14

PPM1A FGFR2 [activation] RPA1 HELQ [activation] CARD11 TAB1 [activation] STX7 VPS18 [activation] TNF TNFRSF1B [activation] GRB2 HP [activation] EGFR NCK2 [activation] CTNNB1 CEBPA [activation;inhibition] STC2 ADAM11 [activation] CRK SMAD3 [activation] APOH LRP8 [activation] TLN1 YWHAZ [activation] RANBP2 UBE2I [activation] TLN1 ACTA1 [activation] FOSL1 JUNB [activation] NUP153 ESR1 [activation] MCC SMC4 [activation] CREBBP HCK [activation] HSPA6 STK4 [activation] PRKG1 ITPR1 [inhibition] STK4 HAL [activation] SDCBP RAB5A [activation] TWF2 ACTR3B [activation] MAPRE1 TERF1 [activation] TEC TP53 [activation] NCK1 EGFR [activation] TGFB2 ENG [activation] NT5DC2 EGFR [activation] AKT1S1 YWHAZ [activation;inhibition] PTPRB EPOR [activation] LAMTOR4 LAMTOR1 [activation] RXFP2 INSL3 [activation;inhibition] TAB3 MAP3K7 [activation] KMT2C TP53 [activation] ATF2 ITGA2 [activation] CNTNAP4 MAST3 [activation] CEBPB SMAD4 [activation] FRS3 GATA1 [activation] ARHGEF7 ARHGEF6 [activation] IGHG1 TNS3 [activation] FOXM1 FZR1 [inhibition] SFN IRS1 [activation] PTCD3 ATF4 [activation] SCAP INSIG2 [activation] CSNK2B NPAS2 [activation] ACVR2B MSTN [activation] MBP TRAF6 [activation] MAST2 YWHAB [activation] FXYD6 BCAR1 [activation] MRPL12 MDM2 [activation] MYOG MLH1 [activation] RHOU PTK2 [activation] CRK SOS1 [activation] RRM2 DNM1L [activation] POLR2A MYC [activation] PCNA MDM2 [activation] CDC5L ESR2 [activation] HRH4 GNAI1 [activation] RB1 SKI [inhibition] PEX14 HSD17B4 [activation] PRKCB PPP2CB [inhibition] KPNA2 CDK5RAP3 [activation] MYF6 ID1 [activation] PRKCB AR [activation] HSP90AB1 HIPK4 [activation] CDK7 SMAD1 [activation] LGR4 SMC4 [activation] YWHAB CDC25A [activation] HES1 NR4A1 [inhibition] MMP1 ITGA2 [activation] IL2RB SYK [activation] TLR4 BTK [activation] MRPL32 ICT1 [activation] STK11 TBC1D23 [activation] SRPK2 NGLY1 [activation] CBL GRB2 [activation] 页 203 共 454


2016/4/8 19:14

TP53 FOXO3 [activation] NXF1 INF2 [activation] CDKN1A VIM [inhibition] SYN1 PLCG1 [activation] FBXO6 IGF1R [inhibition] CASP8 MAP4K4 [activation] FBXL15 BHLHE40 [activation] EIF4G1 EPB41 [activation] MYO6 GRB2 [activation] HSP90AA1 DDR2 [activation] RIBC2 RAD54B [activation] KDR MET [activation] BCR PTGES3 [activation] NUDC MAEL [activation] MDC1 PGAM5 [activation] GTF2B ATF4 [activation] FKBPL CYFIP1 [inhibition] RCC1 NXF1 [activation] CKS1B CDK1 [activation] HOXB13 ELK1 [activation] LYN CREBBP [activation] NUDT18 TRAF2 [activation] FYN DAB2 [activation] TP53 MRPS2 [activation] MCM7 SIPA1L1 [activation] CD72 PTPN6 [activation;inhibition] RAP1GAP FBXW11 [inhibition] PLXNA1 KDR [activation] KBTBD4 MPP3 [inhibition] NOS1 CTBP1 [activation] BRF1 TP53 [activation] CAV1 GRB7 [activation] GRB2 KIAA1549L [activation] HLA-A ERBB3 [activation] LRP6 CAPRIN2 [activation] ITGA4 TIAL1 [activation] ABL1 YWHAH [activation] TLX3 HIST1H2BJ [activation] EIF4G1 ESR1 [activation] RASA1 AURKA [activation] UBE2V1 PELI3 [activation] PPP2R2B ACACA [activation;inhibition] MMP2 PZP [inhibition] ODF2L ERBB3 [activation] CASP7 HSPA5 [activation] TNFRSF14 TRAF5 [activation] ICAM1 DDX3X [activation] RB1 BRCA1 [inhibition] MTOR STK38 [activation] OPRM1 GNA15 [activation] MDC1 CXorf57 [activation] GRB2 TIAF1 [activation] MYL12B GRB2 [activation] LRRK1 CHGB [activation] NANS SRC [activation] RAN ABL1 [activation] LRRK1 MATK [activation] GAREM CRKL [activation] CTNNB1 NR4A1 [inhibition] HSPA1A MAP3K5 [inhibition] LONP1 APOE [activation] ARHGDIB RAC1 [activation] OSBP VAPB [activation] N4BP1 CDK6 [activation] IGHG1 IGLL1 [activation] ZBTB17 HSP90AB1 [activation] LRRK2 ALDH8A1 [activation] SRC EVL [activation] TCAP MYOZ3 [inhibition] YWHAH CDK16 [activation] BIRC3 RAF1 [activation;inhibition] AURKA MAPK6 [activation] HIF1A RELA [activation] IL21R JAK1 [activation] PPP2CA PPP2R2D [activation] GCN1L1 CASP4 [activation] 页 204 共 454


MAX MAPK1 CNTF TP53 MYC GAPDH HOOK2 ZZEF1 CPSF3 RPA1 PPP1CC BUB1B THSD7A GIPC1 MYC GATA1 CTNNB1 CSRP2 ITSN2 DNAJA1 PVR MCM6 SUDS3 BCL6 ABI1 YWHAZ TRAF3 PROS1 FTSJ1 PPP6R2 ERF SORBS3 SPI1 CAMK2A TAB1 SOCS1 ROBO2 RFX7 RPA1 IPO5 LUZP2 CAMK2B RAP1A EIF1AX LCK VCAM1 NOTCH1 SREBF2 ERBB3 RAPGEF2 AKT2 MSX1 PRKCD CALM1 CSNK1E YWHAZ GDI2 LYPD3 CTSB SNX7 MIF ITCH GRIA2 HSD3B7 PPM1A RPA2 IKBKE PDPK1 MDM2 HERC1 YWHAZ POM121 MMP3 AURKA POU4F1 MLH1

2016/4/8 19:14

PLEKHA5 [inhibition] NCOA1 [activation] STK16 [activation] ANG [activation] SAMD9L [activation] SNCA [activation] EGFR [activation] SKIL [activation] NXF1 [activation] EIF2S2 [activation] CCNB1 [inhibition] SIRT2 [activation] RAD21 [activation] ZFPM1 [activation] MICALL2 [activation] CEBPE [activation] PTPN6 [activation;inhibition] PIAS1 [inhibition] CCDC88C [activation] TNFRSF14 [inhibition] PVRL1 [activation] HSPB1 [activation] LRRK2 [activation] EBF1 [activation] NCK2 [activation] HDAC4 [activation] CBLB [inhibition] C4BPA [inhibition] IGF2BP1 [activation] PRKDC [activation] MAPK1 [inhibition] WASF2 [activation] BCL6 [activation] ITPKA [activation] GRB2 [activation] VHL [inhibition] KCNRG [activation] MYC [activation] DNTTIP1 [activation] RAN [activation] ESR1 [activation] SEMA4G [activation] TNFRSF10C [activation] TRAF6 [activation] GAB1 [activation] GNB1 [activation] IKZF1 [activation] ABLIM1 [activation] RGS4 [activation;inhibition] SLC25A11 [activation] CLIP3 [activation] SP1 [activation] ADRA2A [activation] ADRB2 [activation] DBNDD2 [activation] RAP1GAP2 [activation] SMURF1 [inhibition] SMAD4 [activation] CDKN1A [activation] GRB2 [activation] TNFRSF14 [activation] YAP1 [activation] REST [activation] ICAM1 [activation] ARRB2 [activation] TIMELESS [activation] GMFB [activation] FAM213B [activation] G3BP1 [activation] ARF1 [activation] PAK1 [activation] PAXIP1 [activation] SERPINE1 [activation] PLK3 [activation] ESR1 [activation] SMAD1 [activation] 页 205 共 454


2016/4/8 19:14

POLR2B BARD1 [activation] PTGS2 SUMO1 [activation] ARHGAP26 INSR [activation] VAV1 MAPK1 [activation] RASSF6 SAV1 [activation] TRIM28 H3F3A [activation] PIGR STK4 [activation] CREB3L1 CREM [inhibition] PTEN MAST1 [activation] MTM1 KMT2A [activation] CASP6 DSP [activation] DHX15 CD81 [activation] OBSL1 STAG2 [inhibition] GABARAPL2 PRKDC [activation] SLC35G2 SEMA3F [activation] ENAH MYO10 [activation] IRS4 P4HA1 [activation] OSBPL11 VAPB [activation] TGFBR2 NRP2 [activation] APOC1 APOA1 [inhibition] PAFAH1B2 PAFAH1B3 [activation;inhibition] SLC9A3R2 PIK3CA [activation] CCND1 SMAD1 [activation] SMAD2 DNAJA2 [inhibition] MAPK6 TTK [activation] TERF1 RIC8A [activation] TGFBR2 ARHGEF6 [activation] RALBP1 RAC1 [activation] ASB2 JAK2 [activation] MAPK3 TTYH3 [activation] TP53BP1 CDC27 [activation] SMAD4 STK11IP [activation] CDK2 PPP1CA [activation] TFCP2 MAPK14 [activation] SMAD3 HDAC4 [activation] CDH1 YES1 [activation] MAFA MAPK14 [activation] MAPK3 CREBBP [activation] SREBF2 PIAS1 [activation] MAPK8 WDR62 [activation] C6orf47 ENO2 [activation] STK11IP STK11 [activation] YWHAB GEM [activation] FZR1 MDC1 [activation] PPP2R2D JUN [activation] PSEN1 GSAP [activation] GATA3 RARA [inhibition] MYC AFAP1 [activation] CDK2 GSTM2 [activation] SH3GL2 IGHM [activation] TP53 WDR5 [activation] SMARCA2 STAT1 [activation] WNK1 RANBP9 [activation] AR HCK [activation] CCDC67 GEM [activation] WASH1 EXOC1 [activation] ITK BTK [activation] MS4A1 FMNL1 [activation] LTBP3 TGFB2 [activation] SIKE1 STK24 [activation] APC TAF1 [activation] NXF1 YWHAZ [activation] IFI35 MAPK1 [activation] YWHAG FAM13B [activation] ACACB HLCS [activation;inhibition] RPS6KB1 MAPK8 [activation] KLHL2 WNK1 [activation] IRS1 DVL2 [activation] HSPA8 GRB2 [activation] DAPK3 HSP90AB1 [activation] ARAF PPP6C [inhibition] YWHAZ ASS1 [activation] LUZP4 SRPK2 [activation] DAB2 LDLR [activation] GNAQ NT5C3A [activation] VCAM1 PICALM [activation] 页 206 共 454


2016/4/8 19:14

CRKL CRK [activation] HSP90AB1 ACVR2B [activation] CSNK2A2 SNCA [activation] KCNA4 INADL [activation] TP53 USP42 [activation] MDM2 POLE [activation] CDC23 PTBP3 [activation] DLGAP1 CTNNB1 [activation] ARF6 EIF4G1 [activation] FST BMPR2 [activation] TP53BP2 NXF1 [activation] HSPB1 ASB6 [activation] LIG3 JTB [activation] RRP12 FOS [activation] CDK6 CCNE1 [activation] SPP1 SNAPIN [activation] GRM5 PRKCZ [activation] PAK1 LYN [activation] MPP3 RRAGC [activation] PRKAA1 HSP90AA1 [inhibition] RAC1 LTBP3 [activation] ZRANB1 TRAF6 [activation] PYHIN1 LIG3 [activation] SRY SLC9A3R2 [activation] ZC3H10 DAB1 [activation] RAE1 NUPL2 [activation] JUP CDK5RAP3 [activation] CTSE INS [activation] PAXIP1 RLTPR [activation] ICT1 RPUSD4 [activation] GRB2 SYNJ1 [activation] ITSN2 ROCK1 [activation] RASSF10 S100A14 [inhibition] TBC1D22B PNMA5 [activation;inhibition] FAM154A CRK [activation] FKBPL AAR2 [activation] PPP2R5A MAPT [activation] RGS6 GNB4 [activation;inhibition] TNIK TRAF6 [activation] USHBP1 CCDC148 [activation] PRMT5 PAXIP1 [activation] PLCG1 GNB2L1 [activation] RPS6KB1 EIF3F [activation] SMPD1 ANXA7 [activation] NFKBIA TGM2 [activation] CAPN1 PALB2 [activation] RUNX1 CBFB [activation] ILK TMSB4X [activation] MEIS1 CRTC2 [activation] CTNND1 YWHAG [activation] YWHAB IRS1 [activation] GAD1 PPP2CA [inhibition] NEDD1 HNRNPA1 [activation] MAP2K4 FLNC [activation] CENPT DHX29 [activation] EIF2B1 ADRA2B [activation] HLA-B CSF1 [activation] FRS2 NTRK3 [activation] POLA2 CRELD1 [activation] CDC27 FZR1 [inhibition] STAT3 FHL2 [activation] APP DNAJB1 [inhibition] CDK5RAP2 CDK5R1 [activation] CITED2 TBP [activation] BMPR2 UBC [activation] RAB8B CDH2 [activation] MICALL1 RAB10 [activation] CD81 HIST1H2BB [activation] CALM1 OBSCN [activation] ARHGEF11 PLXNB2 [activation] PAX8 CLSTN1 [activation] MKNK1 EIF4G3 [activation] FZR1 FBXO5 [inhibition] GRB2 PANX2 [activation] MYL12B DAPK1 [activation] AR CASP8 [activation] 页 207 共 454


2016/4/8 19:14

PRKCH HSP90AB1 [activation] NFATC2 SUV39H1 [activation] SATB1 PIAS1 [inhibition] SRPK1 SFMBT1 [activation] TNNT1 NFE2L2 [activation] TDRD1 PLCG1 [activation] APLP2 CDK1 [inhibition] CRK ERBB4 [activation] FGFR1 BNIP2 [activation] PTPN11 MPL [activation] SGTA SERPINE1 [inhibition] SDC1 PTN [activation] SUMO4 STAT1 [activation] TGIF1 SMAD3 [inhibition] FYN BRPF3 [activation] ARVCF CDH1 [activation] MAP4K4 PAXIP1 [activation] YWHAE SLC8A3 [activation] SMC4 RPA1 [activation] CDC14B SKP2 [inhibition] CHEK2 KAT2B [activation] PAFAH1B3 GDF9 [activation] HNF4G NSD1 [activation] LTB TNFRSF1A [activation] KNG1 PREP [activation] CRKL MAPK1 [activation] SH3GL2 PAXIP1 [activation] CFHR2 APP [activation] PLK1 GORASP1 [activation] CDK4 MCC [inhibition] DAPK3 ATF4 [activation] UBE2E3 ARRDC1 [activation] DCC TBC1D2 [activation] EIF1 APP [activation] TP53 MPHOSPH6 [activation] CEBPE ATF4 [activation] TRIM28 HLA-B [activation] KLRB1 PTPN6 [activation;inhibition] RORC RORB [inhibition] PLXNB2 MET [activation] GRIP1 RXRA [inhibition] NOTCH2NL FASLG [activation] ITGB4 ERBB2 [activation] PCSK1 CTNNB1 [activation;inhibition] SPOP GLI2 [inhibition] SYK ITGA4 [activation] EDA2R CASP10 [activation] TRAF2 RHEB [activation] SERPINE1 F2 [inhibition] PLK1 CSN1S1 [activation] STX5 APLP1 [activation] RXFP3 RLN3 [activation] NXF1 NME4 [activation] AGAP8 HSPB1 [activation] RRM2B ATM [activation] XIAP TBK1 [inhibition] HDAC4 BCL6 [activation] LYN CDK2 [activation] EHBP1 EHD1 [activation] CDKN1A CIZ1 [activation;inhibition] RAC1 PRKCD [activation] RPUSD2 GRB2 [activation] IRF2 HMGB1 [activation] MLH1 ABHD16A [activation] ABI1 HSPA8 [activation] WNK1 HDAC9 [activation] ESR2 WIPI1 [activation] ACAP3 TAB1 [inhibition] LYN FCAR [activation] YWHAB NF1 [activation] SIGIRR IL1R1 [activation] DCN COL6A1 [activation] FSCN1 PRKCD [activation] IL32 ZFPM2 [activation] GRB2 KRT33B [activation] CDK1 PPP2R1B [activation] 页 208 共 454


2016/4/8 19:14

CDC42BPA PPP1R12C [activation] BRCA2 KAT2B [activation] EPOR LYN [activation] FAN1 KPNB1 [activation] SMAD3 RIOK2 [activation] MC3R POMC [activation] SMARCB1 BCL7C [activation] CRK ASAP1 [activation] RASA1 CD5 [activation] TGFBR1 GNB2 [activation] GNAS MSANTD3 [activation] PTK2 GIT1 [activation] HSP90AB1 PTGES3 [activation] ATR MCM2 [activation] LILRB4 PTPN11 [activation] HDAC1 IFRD1 [activation] PRKCB ITGB7 [activation] PAK2 MAPK1 [activation] BCL6 UTP6 [activation] GET4 AKT1 [activation] MTA2 APPL1 [activation] YWHAE TLK1 [activation] BTK MAL [activation] EEPD1 KCNIP4 [activation] PRKCI DUSP1 [activation] PTPRF RET [activation;inhibition] UBE2I SOX6 [activation] PPP3CB MYOZ3 [activation] RCN1 JAK2 [activation] NFKBIA HDAC4 [activation] RHOA KCNA2 [activation] YES1 C1orf94 [activation] GNB2 GNAI1 [activation] STK4 CALML5 [activation] CENPJ PLK2 [activation] KLF6 E2F1 [activation] MAX SPAG9 [inhibition] TNK1 YWHAG [activation] NEDD4 CAMK4 [inhibition] PLCG2 HCK [activation] ICAM1 HIST1H2BH [activation] PAK1 FOXL2 [activation] BMP4 CHRDL1 [activation] GRB14 DAPK3 [activation] CAMK2G NR1H2 [activation] ZFYVE9 PPARG [activation] WFIKKN1 TGFB1 [inhibition] SAV1 RASSF1 [inhibition] NFKBIA CSNK1A1 [activation] GAPDH GSK3B [inhibition] HSP90AA1 CAMK2A [activation] NUP93 ITGA4 [activation] YWHAQ GCN1L1 [activation] MYC DNAJB12 [inhibition] RAD51 PALB2 [activation] STX4 GIMAP5 [activation] MAPK9 STAT3 [activation] CSF1R PIK3R1 [activation] CYTIP CYTH2 [activation] SAA4 IGHG1 [activation] PTN ITSN2 [activation] APP BACE2 [activation] SORT1 SORCS1 [activation] CUX1 RECQL5 [activation] TRAF6 UBE2D3 [activation] STX6 MOV10 [activation] STX5 MAGEA6 [activation] SSTR4 SST [activation] LYN NFYB [activation] PRPF6 WHSC1 [activation] HNF4A TP53 [activation] DHX37 PLXNA2 [activation] RAC1 TUBA4A [activation] BID BAG3 [activation] VCAM1 S100A7 [activation] RASA1 BCR [activation] 页 209 共 454


2016/4/8 19:14

THBS1 TGM2 [activation] CHUK MYH14 [activation] NBN RICTOR [activation] EEA1 RAB5C [activation] KIT YES1 [activation] YWHAG ERC1 [activation] CSK SRCIN1 [activation] MASP1 GADD45A [activation] RNASEL IQGAP1 [activation] CAST CASP3 [activation] CREBBP HIPK2 [activation] PGR NR0B1 [activation] MECOM EHMT2 [activation] CRKL LYN [activation] XPO5 NOTCH1 [activation] MAPK8 EZR [activation] ITSN1 PICALM [activation] DHPS NUDT18 [activation] GABARAP GABARAPL2 [activation] HLA-B SSSCA1 [activation] ECE2 CASP10 [activation] TNFRSF14 GET4 [activation] ABHD16A IFITM1 [activation] DAB2 DVL1 [activation] VPS52 STX6 [activation] CDKN2AIP MDM2 [activation] KIAA1377 MAPK9 [activation] NOL6 OBSL1 [activation] OPRM1 CALM1 [activation] UBE2E2 RNF5 [activation] IGHG2 USF2 [activation] MAPK4 ERC1 [activation] HTR1A GABBR2 [activation] UBE2L6 RUNX1 [activation;inhibition] GNB2L1 VCAM1 [activation] EPB41L5 ESR2 [inhibition] ARF6 NCAPG [activation] SRC SH3BP2 [activation] MLH1 PSD3 [activation] PLCG1 NELL1 [activation] YWHAB PTPN13 [activation] GLI2 ZIC1 [activation] HSPB1 IARS2 [inhibition] GSK3B PIM2 [inhibition] HLA-B RPA3 [activation] RPTOR HIF1A [activation] CASP8AP2 CALM1 [activation] XIAP IRF3 [inhibition] EIF3I ARF6 [activation] STX11 TBK1 [activation] CDH2 SKP1 [activation] SMAD1 PUM1 [activation] FXYD2 ATP1A1 [activation] ACVR1B SMAD7 [activation] HOMEZ PRKAA1 [inhibition] MYO1C ESR1 [activation] DKC1 MCM7 [activation] LAT PIK3R1 [activation] SOCS6 MET [inhibition] PSEN2 FHL2 [activation] MAPK4 HSP90AB1 [activation] F2R PDCD6IP [activation] HNRNPA0 RPA3 [activation] FBXO11 MIF [activation] GLI1 DYRK1A [activation] ABI3 PAK1 [activation] CSK CD44 [activation] RHPN2 TRAF6 [activation] AZI2 TRAF3 [activation] CASP8 GRIA1 [inhibition] STK16 HNF4A [activation] GSK3B DNAJC13 [activation;inhibition] FLT1 TMCO4 [activation] ERBB2IP STAT3 [activation] INSIG2 AMFR [activation] ESR1 SMAD2 [activation] 页 210 共 454


SUMO3 TRDN TRAF6 MTOR GRK1 CALM1 GNAS CAV3 CDX2 SMARCA4 EIF3L LRRK2 NUP214 RAE1 SOS1 SH3BP5 CD2 CD59 ANAPC15 CDC27 KDM6B WAS METTL23 BCL2L1 APP CLDN20 HIST1H4A CREBBP SMARCB1 TTI1 RICTOR MAPK9 GRB2 APP PLEKHG2 SF3B1 ARF6 CD81 EEF1D YWHAZ EFNB3 GTF2A2 GTF2A1L YWHAG KIF23 FTSJ3 MAGEB4 PTK2 NEO1 HTR2A NME3 GRB2 FGD6 DPY30 OGT SH2B2 SORBS1 AKT1 HSPB1 CAMK2A YWHAQ DHX15 ITGA4 BCAS3 KRAS SGK1 DDX6 PTPRA PRKCD TGFB1 BUB1 GNG12 BLK CRK PPP1CA BMPR2 ACVR1 GABRR1 PRKACA TYRO3 FYN FGR KIT ATF2 PGK1 FADD DAPK1 MC4R ADRBK1 TGM1 ALOXE3 APP LRP1 HMGN1 CHEK2 CCNB1 PCNA SMAD3 CDC27 INSR JAK1 PRKACA ESR1 VTN IGF2 TXNDC5 TRIM42 AMER2 APC HNRNPL VCAM1 FBXO25 HSPA2 SYK IL17RA DVL3 RASSF10 CALM1 CBL ESR1 RPS6KA3 KIAA1737 IL1B ADRB2 PRKACB PRKAR1B CHGB RAC2 ROCK1 NXF1 WNT16 BCL6 STAT1 MTOR PRNP TBPL1 MAPT RPS6KB1 C21orf58 RPA3 PSIP1 PLK1 CCDC115 FHL2 ZFYVE9 PIK3R2 ABL1 CXCR2 GPRASP1

2016/4/8 19:14

[activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] PAK1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] NXF1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] GRB2 [activation] [activation] [activation] [activation] [activation] [activation] 页 211 共 454


PTPN6 BCL2L2 ADAMTS4 DCC EHMT2 CDC42 ITGA4 CTSG CHEK1 TRRAP MAP4K1 ENO1 ABCA1 MPP2 MRGPRX1 HGS TAOK3 PRKCD RAD21 MAPT FBXW7 NXF1 GNA12 VCAM1 RFC4 NXT1 MCM2 SMU1 WDR27 VCAM1 P2RY1 RPS25 EXOC7 ERBB2 USF1 CSNK1G2 PPP2R2B LIPE ANXA5 CSK PHKG1 NOTCH2 CDKN1A CDC23 RBBP5 ERBB3 COL9A3 ZNF747 STAT5B EIF4A2 APP CD247 SMC2 C1QTNF9 CASP3 STAT5B ANAPC15 ESR2 EGFR ZAP70 GATA4 CRKL PRKCD EHMT1 RAN PML INADL RPS6KA3 CHEK1 PIK3R3 TRPC1 NUP62CL MRPL13 CDK8 RARA PRMT1

2016/4/8 19:14

FCRL3 [activation;inhibition] BAX [inhibition] SRPX2 [activation] C9orf156 [activation] EHMT1 [activation] TNF [activation] HIST1H2AG [activation] GP1BA [inhibition] APP [activation] E2F1 [activation] LYN [activation] ARPC4 [activation] SNTA1 [activation] PLK1 [activation] GNB1 [activation] JAKMIP2 [activation] HSP90AB1 [activation] DAB2 [activation] WNT2B [activation] GSK3B [activation] AURKB [activation] ZBED2 [activation] IL3RA [activation] PIK3R2 [activation] MYC [activation] NXF1 [activation] MDM2 [activation] GRB2 [activation] ASNS [activation] PDHA1 [activation] ADORA1 [activation] FOS [activation] ARFGEF2 [activation] HSP90AB1 [activation] KAT2B [activation] PER1 [inhibition] SMC4 [activation] MAPK3 [activation] TUBGCP3 [activation] PTPRB [activation] PHKG2 [activation;inhibition] IL24 [activation] FLAD1 [activation] UBE2S [activation] CTNNB1 [inhibition] FER [activation;inhibition] EGFR [activation] SUFU [activation] CD247 [activation] EIF3D [activation] C10orf88 [activation] TFRC [activation] HIST2H2AC [activation] RDX [activation] UBE4B [activation] STAT1 [activation] ANAPC2 [activation] PIK3R4 [activation] PIK3C2B [activation] ASB3 [activation] KLF13 [activation] NXF1 [activation] ITGB7 [activation] HDAC2 [activation] SMAD2 [activation] FAS [inhibition] LATS1 [inhibition] BAD [activation;inhibition] RB1 [activation;inhibition] DRAP1 [activation] BMPR2 [activation] APP [activation] ICT1 [activation] TP53 [activation] NR1H2 [activation] TNIK [activation] 页 212 共 454


2016/4/8 19:14

RUNX1 SMARCC1 [activation] LFNG APP [activation] NFKB1 NCOA1 [activation] NUDC BTRC [activation] ZFP36 NUP214 [activation] CCR8 TPST1 [activation] EPAS1 F12 [activation] MDM4 E2F1 [activation;inhibition] GAB2 GRAP [activation] PRKCI FRS3 [activation] SH3RF1 RAC1 [activation] YWHAZ EPB41L3 [activation] CDC5L EHMT1 [activation] HDAC1 PPA1 [activation] HSPA4 PRKCD [activation] EGFR GAB2 [activation] PCK1 BSG [activation] MAP3K1 NFKBIA [activation] ARHGAP15 RAC1 [activation] YWHAG IL7R [activation] MAPK1 GMFB [activation] ZC3H4 OBSL1 [inhibition] OBSL1 RAD50 [activation] CAPZB LRRK2 [activation] RORC EIF4EBP1 [inhibition] STAT1 PRMT3 [activation] LAMB1 TGFB1 [activation] TP53 IRF7 [activation] PFN1 RAD52 [activation] CCL7 MMP1 [activation] YWHAB ZAK [activation] IGF1 IGFBP1 [activation] ZYX BCAR1 [activation] ORM2 STK3 [activation] DAB2 NECAP1 [activation] EBLN2 STK16 [activation] BPTF MYC [activation] GRB2 MAP2 [activation] GOSR1 YKT6 [activation] PPP6C EGFR [activation] EGFR MAP4K1 [activation] HLA-B VIPR1 [activation] YWHAG MAPKAP1 [activation] CYBA MYC [activation] CASP6 NUCB1 [activation] YAP1 SLC9A3R2 [activation] CDK5RAP3 MME [activation] RGS14 PRKACA [activation;inhibition] MDM2 HMOX2 [activation] FAM184A PYCARD [inhibition] DOK2 SHC1 [activation] FGFR4 DIRAS3 [activation] NR2F2 NSD1 [activation] F12 UBE2D2 [activation] ESR2 KRI1 [activation] EXOC4 CDC5L [activation] PRKCZ CASP7 [activation] MSTN SGTA [activation] CD81 INPP4A [activation] SMARCA2 NR3C1 [activation] EFNA4 MAP2K4 [activation] NOTCH1 DHX15 [activation] EP300 BANP [activation] CRK NCK1 [activation] LTBP3 PIK3R2 [activation] FAM124A ROCK1 [activation] NR1H3 HSP90AA1 [activation] GART ARF6 [activation] G3BP1 NUP62 [activation] PPP2CB AXIN2 [inhibition] MDM2 PTK2 [activation] PRKCZ LLGL2 [activation] BRCA1 TP53 [activation] DHX33 NUDCD1 [activation] VRK2 MAP2K7 [activation] FOXO1 DYRK1A [activation] 页 213 共 454


2016/4/8 19:14

BCL2L14 BCL2L1 [activation] STAT3 BRCA1 [activation] MAP2K6 RELA [activation] FAS DAXX [inhibition] PPP1CC CDK2 [inhibition] GRB2 SH2D5 [activation] RAB13 SMAD4 [activation] OBSL1 XPO1 [activation] ATG5 HPRT1 [activation] TRIB3 GRN [activation] EP300 KLF2 [activation] PRNP WIBG [activation] UBE2D2 STK11 [activation] RICTOR FLNA [activation] USHBP1 EXOC7 [activation] CD86 ECE2 [activation] GOLGA2 NOS3 [activation] BET1 CCDC155 [activation] CAV1 HRAS [activation] PLCG1 PTPRJ [activation] TRAF3 TNFRSF13C [activation] ERBB2IP SMAD2 [inhibition] SMURF1 RRP9 [inhibition] SCRIB MAPK1 [activation] PPP2R5A SGOL1 [activation] NFE2L2 ENC1 [activation] CRB2 CTTN [activation] SHKBP1 YWHAG [activation] THEM6 ERBB2 [activation] DNM2 ITSN2 [activation] TGFB1 EGFR [activation] FTSJ3 OAS3 [activation] CCNA2 BRCA2 [activation] STK4 LCN1 [activation] MDM4 YWHAZ [activation;inhibition] MOCS3 MOCS2 [activation] HIST2H2AC PRMT7 [activation] CD37 SYK [activation] PGR SP1 [activation] MYD88 POLR1C [activation;inhibition] AP1M2 A2M [inhibition] PML SKIL [activation] COL9A1 MAG [activation] RASD2 ACVR1 [activation] STRN4 STK3 [activation] EIF4A3 ACIN1 [activation] ANXA2 CD4 [activation] VAMP2 VAPB [activation] TFAP2A EPAS1 [activation] CRY2 SKP1 [inhibition] EFHD2 RAD51D [activation] AVPR2 GNAS [activation] KIAA1033 FAM21C [activation] GRIK2 PRKAA1 [inhibition] MDH2 ATF2 [activation] TAB1 HSPA4 [inhibition] CDK7 TP53 [activation] TRAF3 TLR4 [activation] EIF4A2 PIH1D2 [activation] BCR HSPA8 [activation] CREM CREB1 [inhibition] CNTF ICA1 [activation] KLHL1 TGFBR1 [activation] HSPB1 SMARCA4 [activation] PTPN11 SLAMF6 [activation] JAK1 IFNAR2 [activation] NCKAP5 FYN [activation;inhibition] CASP3 DBNL [activation] TYK2 LYN [activation] FTSJ1 YARS [activation] IRF3 RELA [activation] ELAVL1 MAP2K1 [activation] OBSL1 CDCA8 [activation] NXF1 KPNA2 [activation] MAPK1 VCAM1 [activation] MAPK1 MAP2K1 [activation] 页 214 共 454


2016/4/8 19:14

RNF41 RNF166 [activation] IRF1 NFKB1 [activation] CDCA8 NEK3 [activation] YWHAQ BAX [inhibition] RIMBP2 CACNA1A [inhibition] LRPAP1 RTN4 [inhibition] BIRC5 JTB [activation] MYO5A GRIA2 [activation] PRKCZ BCL10 [activation] DYSF CAV3 [activation] VCAM1 ARF5 [activation] FZD2 ROR2 [activation] HSP90AB1 AIRE [activation] CEBPB CEBPD [activation] RPA3 KIAA0196 [activation] APP FMNL3 [activation] DOK1 RASA1 [activation] HSP90AB1 CHEK1 [activation] CSNK1E ACACA [activation;inhibition] PPP2CB CDK17 [inhibition] GHR SGTA [activation] HSPA2 MEOX2 [activation] PDPK1 SRPK1 [activation] AURKB ABR [activation] CCNB1 TGFBR2 [inhibition] SRPK1 CACNB1 [activation] NXF1 ANAPC1 [activation] EP300 ATG7 [activation] TERF1 NBN [activation] RASA1 NCK1 [activation] VCAM1 TAGLN2 [activation] LRRK1 GAK [activation] STK3 HSPE1 [activation] PTK2B STAP1 [activation] KNG1 CPN1 [activation] PTPN6 IRS4 [activation;inhibition] JUN KMT2C [activation] AKT1 FAM110C [inhibition] ENO1 GRB2 [activation] NOS3 ACTB [activation] EP300 IRF3 [activation] MAGEB2 MAD2L1 [inhibition] TRAF2 CCDC130 [activation] TP53 PRKRIR [activation] CASP8 CNBP [inhibition] PLK2 CASK [activation] PLCG1 PPFIA4 [activation] CD3D CD247 [activation] NCK2 BLNK [activation] RABEP1 HUNK [activation] TDG RXRA [inhibition] SMARCA4 EPAS1 [activation] SMAD1 NAT9 [activation;inhibition] IL2RB FYN [activation;inhibition] PAX8 PKM [activation] CSN2 NEK8 [activation] NR5A1 GRB2 [activation] EPHB3 CRK [activation] SNAP25 HGS [activation] TAX1BP3 GATA1 [activation] APP SSH3 [activation] JDP2 CREBBP [activation] BAIAP2 SRPK2 [activation] OGT SMURF1 [activation] GBF1 YWHAG [activation] ITGA4 SRI [activation] EGLN3 ADRB2 [activation] TP53 DGCR14 [activation] SETDB1 POLA2 [activation] RAC1 ARHGEF2 [activation] ADRA2A GNG2 [activation] TAGLN2 ATG5 [activation] TFPI MMP7 [inhibition] MACF1 CDC5L [activation] JUN NCOA1 [activation] PRKAA2 HNF4A [activation] 页 215 共 454


2016/4/8 19:14

HSPA4 TGFBR1 [inhibition] RAC1 MAGI1 [activation] HRAS AGTR1 [activation] SNCA UBB [activation] KLHL35 TGFBR1 [inhibition] CDK5 EGFR [activation] ATR FAM133B [activation] JAK2 VAV1 [activation] RPA1 HNRNPL [activation] FYN DLGAP2 [activation] CREBBP CREB1 [activation] LRRC47 LRRK2 [activation] PNP HLA-B [activation] G3BP1 RAD21 [activation] BCR YWHAB [activation] PRNP TSLP [activation] IRS4 PCK1 [activation] ATM NABP2 [activation] HPN HGF [inhibition] BRAP IKBKB [activation] MYLPF PPP2R4 [activation] KMT2A HCFC2 [activation] UBE2E3 ITCH [activation] LGALS9B DAB1 [activation] TRPV4 LYN [activation] ATF7 TAOK3 [activation] PHKG1 CTRC [activation;inhibition] SHC1 PRKDC [activation] STAT3 SUMO4 [activation] SRPK1 PELI2 [activation] MS4A2 PRKCD [activation] CAND1 ENO2 [activation] PYCARD CCDC135 [inhibition] MT1A GNAI1 [activation] CDKN2A UBE2A [inhibition] PRKCD CD34 [activation] FOS CARM1 [activation] HSPA1L YWHAZ [activation] CBLB ASAP2 [inhibition] DFFA LRRK2 [activation] HNRNPA1 ICAM1 [activation] RNF41 ERBB4 [activation] RIPK2 HSPA2 [activation] METTL2B PSEN2 [activation] SNW1 LRWD1 [activation] HSP90AA1 MDM2 [activation] SH3GL3 EGFR [activation] PLEKHB1 TGFBR1 [activation] CD274 PTPN11 [activation] BCAR3 WHSC1L1 [activation] PIM2 SOCS1 [inhibition] SPP1 CTNNBL1 [activation] UBE2I RPS6KA6 [activation] NXF1 SRBD1 [activation] GADD45G GADD45A [activation] RAD17 RAD50 [activation] BLNK HSPH1 [activation] RPA1 RAD50 [activation] PRKRIP1 EIF2AK2 [inhibition] PKIG PRKACA [inhibition] HSP90AB1 EPHA4 [activation] WNK4 HSP90AB1 [activation] YAP1 EGFR [activation] EFNA1 EEF1G [activation] TFAP2A EP300 [activation] BCL3 RELA [activation] STK38 KMT2E [activation] MDC1 VAMP5 [activation] RICTOR MLST8 [activation] HBG1 APP [inhibition] STK11 YWHAZ [activation] MAPRE1 STIM1 [activation] WASF3 ACTR3 [activation] PLOD1 H2AFX [activation] MCM2 P2RX4 [activation] MST4 STK24 [activation] 页 216 共 454


GSK3B STAT5A PTTG1 MLH1 ADORA2A CHD8 FTSJ1 MAPKBP1 SMARCA4 TP53 EIF2AK4 PTPN12 NXF1 SMURF1 RPP38 EGFR PTPN11 NUDC EIF3B MC2R NTRK1 CDKN2A S1PR1 DRD3 NMI SRPK2 ACTB EPB41L3 FBXO6 SLU7 SORBS3 EFNA1 MYD88 CDC25C SERBP1 RAD50 CDC20 KLHL11 ZNF512B NRG1 CCDC8 HEMGN ACTA1 CDH24 PAX8 PAK2 DAPK3 YWHAZ BCL6 DIAPH1 TAF1 SMAD3 PTEN ANAPC1 RAD21 PIK3R1 SMAD2 ABL1 CDK11A MYC PTK2 ACTG1 LATS1 CDC27 AURKA ARF6 SRRT MCMBP STOML1 HIF1A RAPGEF1 SST BTG2 RAC1 HERC5 IGF2BP3

2016/4/8 19:14

IGSF21 [inhibition] TSLP [activation] DECR1 [inhibition] PRKDC [activation] CYTH2 [activation] CREB1 [inhibition] ETFA [activation] RGS20 [activation;inhibition] MYOD1 [activation] POLDIP2 [activation] TRAP1 [activation] INSR [activation] IQGAP1 [activation] BMPR1A [inhibition] FYN [activation] TPI1 [activation] PDCD1 [activation] POC1B [activation] ICAM1 [activation] ASIP [inhibition] MAPK3 [activation] EIF1B [activation;inhibition] CAV1 [activation] RDX [activation] MYCN [activation] PRPF4B [activation] RAD52 [activation] IGSF21 [activation] VDAC3 [inhibition] TNF [activation] MAPK1 [activation] SUMO2 [activation] SMURF1 [activation] MAPK9 [activation] ARF6 [activation] MYC [activation] EIF2A [activation] NUDCD3 [activation] IL36RN [activation] EGF [activation] TRAP1 [activation] NRAS [activation] NCOA3 [activation] PPP1R16A [activation] CXCL9 [activation] PIN1 [activation] TP53 [activation] ADAM22 [activation] HNF1A [activation] WWOX [activation] MAX [activation] ACVR1B [activation] IL24 [activation] CDC5L [activation] PCNA [activation] EEF1D [activation] TP73 [activation;inhibition] FYB [activation] GADD45A [activation] NUP188 [activation] ERBB3 [activation] LSP1 [activation] SDCCAG3 [inhibition] CREBBP [activation] MYCN [activation] EMC1 [activation] NOTCH1 [activation] CDC7 [activation] E2F1 [activation] NAA10 [activation] RRAS2 [activation] PDIA2 [activation] PRKCA [activation] HTT [activation] CCNB1 [inhibition] TP53 [activation] 页 217 共 454


2016/4/8 19:14

ACTN1 ATF2 [activation] PRKDC H2AFX [activation] ANXA1 DDX17 [activation] CRK SYN1 [activation] YWHAB MAPT [activation] CCL8 ACKR4 [activation] INSIG2 PSMA7 [activation] ITGA4 EIF4G1 [activation] CDH1 ANP32B [activation] RHOJ WASL [activation] CALM1 RANBP2 [activation] EFNB2 HOMER1 [activation] MYC XPO1 [activation] GHR PTPN11 [activation] PTGES3 SIM2 [activation] TDG DDX39B [activation] HSPA4 BMX [activation] RAN OBSL1 [activation] PIAS2 TRAF2 [activation] RPA3 DHX36 [activation] TRAF3 SAR1A [activation] TNK2 YES1 [activation] GSK3B APP [inhibition] H3F3A ARRB1 [activation] CCNB1 ESPL1 [inhibition] SIRT1 RELA [activation] NAGLU FBXO6 [activation] PPP2CA IER3 [activation] EPHA3 TP53 [activation] RASGRF1 TNK2 [activation] STX7 STX4 [activation] LTBP4 TGFB1 [inhibition] TKT MAPK8 [activation] HDAC4 ATF3 [activation] MYZAP CEBPG [activation] DENND6B MYC [inhibition] HIST1H2AC ITGA4 [activation] DOK1 GABARAPL2 [activation] MNT MAX [inhibition] MARS RELA [activation] SMAD4 FANCC [activation] VPS35 HLA-B [activation] UBC CD2 [activation] RIPK2 HSP90AA1 [activation] BTBD10 LAMA5 [activation;inhibition] CRIM1 CACNA1A [inhibition] HMCES SRPK2 [activation] SLAIN2 SRPK2 [activation] PLCG2 DAPP1 [activation] CDKN1A PIM1 [activation] PKP4 CDH5 [activation] DCD EIF2B1 [activation] EIF2B1 GORASP2 [activation] MAPK9 DUSP8 [inhibition] GIMAP6 APP [activation] ITGB1 MAP4K4 [activation] ADRA2A ADRBK1 [activation] TNFRSF10B TNFRSF1A [activation] EPHA1 HSP90AB1 [activation] SRC SRF [activation] CHEK2 MRC1 [activation] HIF1A ESRRA [activation] S1PR4 GNA12 [activation] ELANE SERPIND1 [inhibition] GRB2 WDR6 [activation] NXF1 EPS15L1 [activation] ACTB AKT1 [activation] CDC5L TWF1 [activation] SUMO1 EIF4A2 [activation] RAB5A ANKFY1 [activation] APP GUCY1B3 [activation] RBL2 TAF1 [activation] CASP6 SRP72 [activation] RAC1 IQGAP3 [activation] EP300 HIST2H2AC [activation] PTTG1 TP53 [inhibition] 页 218 共 454


2016/4/8 19:14

LAMA5 LAMC1 [activation;inhibition] RASA1 MLH3 [activation] FAM98B ZBTB8OS [activation] RPA2 ATM [activation] POLD4 POLE [activation] FTL KNG1 [activation] NCOA3 TP53BP1 [activation] IL1B LYN [activation] JUP BTRC [activation] OBSL1 CCDC8 [inhibition] ERBB2 SFRP4 [activation] SYK MAL [activation] CAMP MAPK8 [activation] RAB11A CHMP1B [activation] CTNNA1 PSEN1 [activation] RASA1 G3BP1 [activation] EHMT1 TP53 [activation] CTNNB1 TP53BP2 [activation] TIFA IRAK1 [activation;inhibition] EFNB2 RGS3 [activation] ITGA4 PCBP1 [activation] PRR20E NCK2 [activation] KIR2DS3 TYROBP [activation] SEC22A MSR1 [activation] SP1 ARHGAP21 [activation] MAP3K10 DNM1L [activation] NCOA1 CIITA [activation] PPP3CA RCAN2 [activation] RRN3 CCNE1 [activation] PFN1 DLG5 [activation] SIRT1 STK4 [activation] BUB3 SMAD3 [inhibition] YWHAZ FOXO4 [activation] FOS CCDC158 [activation] TNFRSF1B CD14 [activation] DAB2 ITGB3 [activation] MYD88 MBIP [activation;inhibition] HSPA5 TG [activation] MSTN APP [activation] ERBB2 VAV2 [activation] CDK20 RAF1 [activation] TP53 TCEAL4 [activation] PTGER1 ADRB2 [activation] SNCA BAD [inhibition] PDX1 CREB1 [activation] AR NCOA2 [activation] ANAPC5 ANAPC16 [activation] GAS7 APBB1IP [activation] APP AKT2 [activation] ADRA1A ABR [inhibition] CSF3R FZR1 [activation] BUB1B BAG2 [inhibition] SRC DUSP15 [activation] PTP4A3 SMC2 [activation] EIF2AK2 RAC1 [activation] SLC2A1 PTK2B [activation] PIK3R1 PTPN4 [activation] EPS15 CRKL [activation] LGR4 GCN1L1 [activation] PAK1 H2AFX [activation] TSHR ADRB2 [activation] GRAP KIT [activation] DDX24 PRF1 [activation] FKBP2 BARD1 [activation] ASAP2 CTTN [activation] MYB PPM1K [activation] ACTR2 OBSL1 [activation] LRRK2 EOGT [activation] ERBB4 RASA1 [activation] NAT9 MAPK6 [activation;inhibition] MOAP1 BCL2L1 [activation] SSH1 ARPC2 [activation] AMOT LATS1 [activation] GP1BB YWHAZ [activation] EGFR NCDN [activation] CSNK2A1 BID [activation] 页 219 共 454


2016/4/8 19:14

TP53 SOCS1 [inhibition] CCDC155 PDGFRA [activation] INS CRYAB [activation] INHBB FNTA [activation] LRP1B SERPINE1 [inhibition] APP GNAT2 [activation] NCAPH2 EGLN3 [activation] FGFR1 NCK2 [activation] MAPK8 TNFSF11 [activation] CREBBP ANAPC2 [activation] PPP1R3D YWHAZ [activation] SRPK1 EIF3M [activation] RRAS ACY3 [activation] CSF2RB FES [activation] AURKA GADD45A [activation] NFKB1 HMGA2 [activation] BACH1 BARD1 [activation] NAA25 CDK2 [activation] LILRB2 HLA-F [activation] GATA1 CCDC24 [activation] RRAGD LAMTOR4 [activation] PIAS4 IRF3 [inhibition] TP53 TAF1B [activation] ERBB3 JAK3 [activation] BRAF LIMK1 [activation] SYN1 SNCA [activation] GAPVD1 CBL [activation] HSP90AB1 CCDC117 [activation] FBXO6 SCAMP3 [inhibition] CLSPN RAD17 [activation] RPA1 TIMELESS [activation] SKP2 CDK2 [activation] VCAM1 AK2 [activation] KLK6 FGA [activation] PCDHA6 BRK1 [activation] AGTRAP NKG7 [activation] YWHAH CYFIP1 [inhibition] ERBB2 SOCS1 [inhibition] MDM2 NUDT9 [activation] CFLAR TNFRSF10A [inhibition] AURKB KLHL9 [activation] YWHAZ MAP3K2 [activation] SOCS2 SOCS3 [inhibition] TP53 EIF2S2 [activation] PPIL1 ITGA4 [activation] ARF1 CHRM3 [activation] PICALM CDC5L [activation] OBSL1 DDX10 [activation] RPS6KA1 FGFR1 [activation] SH2D2A MAPK7 [activation] BRCA1 CDK1 [activation] DAPK3 MET [activation] DAB1 CRKL [activation] SGOL2 MAD2L1 [inhibition] CCNE1 BRCA2 [activation] UBE2K DIABLO [activation] PRTN3 RELA [activation] TNFSF11 MMP1 [activation] CCDC36 CDC23 [activation] APOH TP53 [activation] C8orf74 SUV39H1 [activation] PRKCD AKT3 [activation] AKT1 BCL2L11 [activation] EIF4A1 PRMT1 [activation] APC BAAT [activation] YAP1 WBP1 [activation] UBASH3B JAK2 [activation] REL HSPA6 [inhibition] CACNA1A CACNB1 [inhibition] HNRNPL DAB2 [activation] ILK SYNPO2 [activation] HIST1H1E MAPK13 [activation] TCIRG1 TERF1 [activation] MDM2 RRM2B [activation] MOV10 PALB2 [activation] MIF FN1 [activation] 页 220 共 454


2016/4/8 19:14

MYO1C USP20 [activation] TBK1 CYLD [inhibition] BCL2L1 TMBIM6 [activation] BIRC3 UBE2V1 [activation;inhibition] AURKB KLHL13 [activation] PLEKHG2 RAC1 [activation] PVRL2 TNFRSF12A [activation] SUMO1 DVL3 [activation] CEP76 LATS1 [inhibition] PLD3 STK11 [activation] MYOG PACRGL [activation] F2 HGFAC [activation] CDK5RAP2 STK36 [activation] ATF1 ESR1 [activation] CSK TLR3 [activation] BCL6 CTNNB1 [activation] SRPK1 U2AF2 [activation] DEPTOR MTOR [activation] SYNGAP1 TRIP6 [activation] PRKCB LMNB1 [activation] RAP1GDS1 EGFR [activation] EGFR NUP93 [activation] RNF146 APC [inhibition] ACTR8 BMPR2 [activation] CCDC8 PRKDC [activation] TSC1 TSC2 [activation;inhibition] TNFSF4 TRAF2 [activation] CDH1 PSMC3IP [activation] NGFR TRAF1 [activation;inhibition] APP METTL2B [activation] GRB2 RIT2 [activation] ITCH CBL [activation] FYN IRS1 [activation] SETDB1 TOLLIP [activation] DAB1 LDLR [activation] TSC2 RABEP1 [activation;inhibition] ITGA4 PPP1CA [activation] HSPA6 ADCK5 [activation] MAGED1 DLX5 [activation] SMAD2 FAM161B [activation] MECR PPARA [activation] KIT SLA2 [activation] KMT2A HDAC1 [activation] BTK VAV1 [activation] NFKBIB PPARG [activation] GTPBP1 APP [activation] HSP90AB1 ACTG1 [activation] CIITA MAPK1 [activation] ESR1 EIF4A1 [activation] SHC1 ACLY [activation] RALA EXOC6B [activation] ACSL3 YES1 [inhibition] CCNH GOLGA2 [activation] CAMK2A CDK5R1 [activation] SAA1 COL4A1 [activation] CCDC8 CTNNB1 [activation] PRKCE CFTR [activation] BTRC ATF4 [activation] PPP2R1A PPP2R5B [activation] HIST3H3 HSPA8 [activation] IKZF4 FOXP3 [activation] C4B C2 [inhibition] MYOD1 HIST1H3A [activation] HIST1H2BN ITGA4 [activation] OBSL1 CORO1C [activation;inhibition] KISS1 MMP9 [activation;inhibition] PRKDC EIF2S2 [activation] HES5 STAT3 [activation] PTPN6 KIR2DL3 [activation;inhibition] RAB6B ERC1 [activation] EPAS1 CNOT10 [activation] NARF APP [activation] PARD6A PRKCZ [activation] TNFRSF14 PER2 [activation] WAS FYN [activation] APP NUAK2 [activation] 页 221 共 454


GRB2 DAG1 MXD1 MAX RBPJ RUNX3 SMAD2 EIF3D CCL13 APP CHD1L CTCF GRB7 MET TTC9C ITGA4 CEBPA ATF2 RASD2 SMAD3 BTRC WEE1 STMN1 GLP1R GNL3 STAT3 SAV1 AMOT SERPINA1 RAD21 DAPK3 RIPK1 ACTG1 POLL UBE2H CTNNB1 EPAS1 ARMC7 RUNDC3A RAC1 KPNA2 PIK3R3 ABCB6 CDK1 TGFBR2 AOX1 ABCA1 VAPB PITPNM1 DOK1 PLCG1 PIK3R1 MAP4K1 MAPK13 IGF2BP2 DNM1L MAGEA1 RAB1A CREB1 PTK2 SH3KBP1 VPS13A PIK3R1 HSPB1 XPO1 ATG101 FOXO3 FAM3C CREB3 CHEK1 CHUK HSPA5 EP300 CD247 CD3E ARHGAP1 RASA1 AR ERG TNFSF11 TMOD3 MS4A1 FYN BMX APP MAG COL9A3 PRPSAP1 PRPS2 PRKAA2 FLCN IRF1 SP2 CASP1 PSEN2 F2 PROZ YES1 CD46 CD5 CD4 CCR5 IL24 CASP7 ROCK1 GRB2 ARPC1A ILK TWF2 MC4R POMC ICAM1 SET PRKACB RPS6 NFKBIA CALM1 TYROBP KLRC3 SRC ITCH UGT1A7 UGT1A8 FAF2 MYC KIF2A MRPL53 PRKRA GDF9 HSPB1 ENPP2 DDX58 UBE2D3 LRRK1 POLR2M HDAC1 GATA1 ERBB2 ANXA2 HSPA5 BRAF RAP1B HRAS CRK DNAJA3 IL36RN REL RHOBTB2 PALB2 TGM3 USP53

2016/4/8 19:14

[activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] ERLEC1 [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] 页 222 共 454


2016/4/8 19:14

NUP133 LRRK2 [activation] ARPC1B ARPC3 [activation] CDKN1A TRMT2A [activation;inhibition] RELA LARS [activation] RAB14 HLA-B [activation] CDK3 ARRB2 [activation] VAV1 ERBB2 [activation] DUSP15 CRK [activation] CTNNBL1 STAT1 [activation] MDC1 TP53 [activation] GRB2 SLC25A3 [activation] BARD1 TRAF1 [activation] CDK14 CAMK1 [activation] RAD21 CHD4 [activation] PPP4R1 CEP63 [inhibition] G3BP1 TRAF6 [activation] SNAI2 PPP2CB [inhibition] MAPK1 NUP153 [activation] POU1F1 CREBBP [activation] TSC1 YWHAE [inhibition] IRF4 SPI1 [inhibition] UBC INSIG2 [activation] PTPN14 JUP [activation] LYPD3 STK11 [activation] SPP1 C1RL [activation] TMPRSS3 RXRA [inhibition] HES1 FANCE [activation] MCL1 BCL2L1 [activation] CBL CTNNB1 [activation] ESR2 ACTN1 [activation] PXN CTTN [activation] GFRA1 TRADD [activation] CD247 MCM7 [activation] MYD88 TNIP1 [activation] CSDC2 PIK3R1 [activation] MDC1 STAT1 [activation] SMC4 SIRT6 [activation] SMAD3 PPARG [activation] NRAS GRB14 [activation] PSIP1 HMGA2 [activation] PPP1CC TRAF3 [activation] SPERT CCNG1 [activation] LRP1 MMP13 [activation] ADCY1 GNAI2 [activation] LRPAP1 SORL1 [inhibition] ARHGDIA ADRB2 [activation] IGF1R ARHGEF12 [activation] LATS1 SCRIB [inhibition] CELSR3 GRB2 [activation] DCAF13 WARS [activation] PRLR CREBBP [activation;inhibition] MEP1B CCK [activation] CUL1 TBK1 [inhibition] EGFR BUB3 [activation] EIF4E2 TRIM54 [inhibition] RHPN1 RHOA [activation] SUMO1 PTPN1 [activation] SYT6 PRKCB [activation] ASH2L MYB [activation] CTNNB1 KDR [activation] TRAPPC1 TRAPPC11 [activation] HRAS CDC25B [activation] CDK5RAP3 IGHA1 [activation] EGFR SLC12A2 [activation] SOCS1 ALK [inhibition] CASP8 RNF34 [inhibition] FYN MAP4K5 [activation] SPOP PIAS1 [inhibition] CYC1 ATF2 [activation] PTPRA PTPRM [activation] MAPK12 ERBB2IP [inhibition] PRKCD PRKCZ [activation] FSHR AKT2 [activation] CDKN1A BRAP [activation;inhibition] GNA13 PPP5C [activation] DEPTOR RICTOR [activation] 页 223 共 454


ADAM22 YWHAH DNAJC8 APP RPTOR DEPTOR PRKACA LRP1 ABL1 RIMS1 XRCC1 TP53 MTNR1A RAP1A GABARAP MCM3 EPHB3 FYN TP53 CSNK2B RARS2 PHLDA3 RHOJ BHLHE40 IKBKG FYN RBL2 CCNE1 ACVR1 BMPR1A C19orf47 TP53 BMX GOLGA2 ITPKB MLLT4 CTNNA1 TP53 GPATCH8 UBE2N RIPK1 EPB41 CD44 BCR PTPN1 MEN1 TP53 MDM2 BTRC DCC CTSV SNAP91 OGT HLA-B NUTF2 DDA1 PGK1 EP300 FOSB IRS2 SFN MAGI1 RPS6KA3 SREBF2 RAB11B PPP1CC BCL2L1 PF4 SDC2 CSDE1 TRAF6 WASF1 ABI2 NR3C1 RAF1 LRRK2 AURKC TBC1D8 SPP1 NCL RICTOR RNF7 CASP7 ATG5 FABP5 SRC INSR HRAS GREB1 ARRB2 EGFR CD3G CD3E CTNNB1 NDRG1 BAG2 JAK3 HTRA1 COL1A1 MCM3 MAPK6 CALM1 LY96 SMAD1 USP9X PIAS1 GRM8 CDK16 CDK5R1 EP300 SMARCA2 TNFAIP3 TP53 HSP90AB1 BANP HIF1A F2R FLOT2 TAL1 ETS1 LIMK2 LIMK1 HLA-A BCAP31 ITPR1 LYN SMARCE1 NCOA1 LAT LCP2 IL1R1 IRAK1 XPO1 SMAD1 SETDB1 GIPC2 RACGAP1 PPP2CA HSP90AB1 ICAM1 RPS3A SLC6A3 SNCA INSIG2 UBQLN1 PIK3CA ATPIF1 DNAJB1 CDC37

2016/4/8 19:14

[activation] [inhibition] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation;inhibition] NTM [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] RPS6KA2 [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] IFIT1 [activation] [activation] [activation] [activation] [activation] [inhibition] 页 224 共 454


2016/4/8 19:14

HES6 TWIST1 [activation] IGF2BP1 TP53 [activation] RXRA GADD45A [inhibition] BMX CRK [activation] TSSK4 CREB1 [activation] BACH1 HMMR [activation] SMAD3 MAX [inhibition] HSPB1 MRPS23 [inhibition] H2AFX PPP2R4 [activation] COPS3 STK11 [activation] VIP DPP4 [activation] PPP2R5E CHEK2 [activation] VAV2 STK24 [activation] GNAS RGS2 [activation] BAD BCL2L11 [activation] DUSP3 EGF [inhibition] NCL HCK [activation] BRCA1 SMAD2 [activation] CAMK2D CAMK2G [activation] ITGA4 ADAM28 [activation] CDK10 PIN1 [activation] RALA EXOC8 [activation] EGFR DOK2 [activation] CD38 CBL [activation] CCND1 CKS1B [activation] CRLF2 IL7R [activation] RHOU NCK1 [activation] SMAD1 TLR2 [activation] HTT PTK6 [activation] TP53 MAPKAPK5 [activation] ITPR1 CCNB1 [inhibition] PRKD1 EGFR [activation] MARK3 FANCF [activation] PSEN1 PIK3R1 [activation] STK3 PRKRIR [activation] FANCG ZBED1 [activation] HSP90AB1 CAMKK2 [activation] FBXW11 PRLR [inhibition] PPARG CHD8 [inhibition] SGK1 HNRNPM [activation] HDAC1 CDKN1A [inhibition] EGFR HELLS [activation] MRPL36 RRAS [activation] GADD45A HIST3H3 [activation] RAN CFTR [activation] ARRB2 IGF2BP1 [activation] CCNF CCNB1 [activation] DOCK7 RHOA [activation] IQGAP1 PODXL [inhibition] HSPA8 MAP3K7 [inhibition] MGEA5 NUDCD3 [activation] VCAM1 VCL [activation] HIST1H3A CD81 [activation] SMAD3 MECOM [inhibition] DOCK9 SMAD3 [activation] SMAD9 TBCD [inhibition] GADD45G KIAA1377 [activation] EGFR HSPA2 [activation] FBXL21 CRY2 [inhibition] ILK FANCI [activation] BRAF ZNF189 [activation] MAATS1 MYC [activation] CLDN3 PRKACA [activation] PRKAR1A WNK1 [activation] HNRNPA1 MEF2A [activation] FYB GRAP2 [activation] HIPK4 CTSB [activation] ACTG1 APOE [activation] SMURF1 ROCK1 [activation] HSPA7 GABARAPL2 [activation] TRAF2 HSPA1L [activation] USP9X SMAD2 [activation] TERT MCRS1 [activation] ETFA CDC42 [activation] SRPK1 RPS6KB2 [activation] COL1A1 ANXA1 [activation] 页 225 共 454


2016/4/8 19:14

LRRK2 SF3B2 [activation] YWHAZ CDC25A [activation] RIPK1 HSPA1L [activation] BCAP31 VAMP3 [activation] MAPK8 BID [activation] EPAS1 SMARCC1 [activation] IGHG1 NUP214 [activation] BCL6 TRAF1 [activation] TRMT2A PIK3R3 [activation] MYD88 IL1RAP [activation;inhibition] HSPA8 EIF4A3 [activation] NUP155 CDK4 [activation] TRIM24 NFE2L2 [activation] ULK1 GABARAPL2 [inhibition] KIF23 PPP2R5E [activation] MAPK1 TNIP1 [activation] PPM1A AXIN1 [activation] RARA FOS [activation] ATF5 EP300 [activation] EHMT1 BCL6 [activation] SETDB1 NUDCD3 [activation] HIST1H4A RAD21 [activation] PIK3R1 WASF1 [activation] ZFP36 TNF [activation] RLTPR NOTCH1 [activation] RPA1 STRA13 [activation] ATM CSNK1D [activation] RYR1 GRB2 [activation] TPRN PPP1CA [activation] MDC1 CREBBP [activation] TLR5 TLR4 [activation] PLK1 LATS1 [inhibition] HSPA1L GABARAP [activation] WAS WIPF1 [activation] MRRF APP [inhibition] FGF2 PTX3 [activation] PRKRIP1 TRAF2 [activation] RGS4 PLCB1 [activation;inhibition] NOS1 VAC14 [activation] TNFRSF14 TNFSF13 [activation] SYN1 CAMK2G [activation] TLR2 IRF3 [activation] TGFBR1 STYXL1 [inhibition] PRKDC RBBP8 [activation] RNF10 GRB2 [activation] TNFRSF8 TRAF5 [activation] GRB2 PIK3R2 [activation] COMMD8 RELA [activation] BLNK GAB1 [activation] GRB2 PNMA2 [activation] SMAD3 HMGA2 [activation] PDCD5 ACP5 [activation] CBL UBASH3B [activation] MAVS SRC [activation] GOLGA8F BAAT [activation] UBE4A CASP6 [activation] C1QTNF2 TRIM54 [activation] NCK2 SOS1 [activation] SERINC3 KDELR2 [activation] HSP90AB1 MAPK6 [activation] RINT1 RB1 [inhibition] TNFRSF10A CD4 [activation] NTRK2 PTPN11 [activation;inhibition] ZNHIT3 MEIS2 [activation] DLGAP4 GRB2 [activation] ARF5 RAB11A [activation] TMX1 H2AFX [activation] LXN PPM1A [activation] MTOR TP53 [activation] SRPK1 WDR55 [activation] PRKCA XK [activation] RELA STAT1 [activation] DAPK1 CCNDBP1 [activation] ATM HLA-A [activation] LATS1 FOXL2 [inhibition] PKM EP300 [activation] 页 226 共 454


2016/4/8 19:14

MCM7 ITGA4 [activation] TRAF6 FYN [activation] HBZ DOCK8 [activation] ANAPC4 CDC20 [inhibition] RAPGEF3 RAN [activation] STAT3 SSSCA1 [activation] TRAF2 UBE2V1 [activation] E2F1 ARID3A [activation] RAP1B TLE1 [activation] CEACAM3 SRC [activation] RASGRF1 YWHAE [activation] CHEK1 XIAP [inhibition] EFNA5 ABL1 [activation] PSIP1 SH3KBP1 [activation] CCDC90B RGL2 [activation] EP300 RPS6KB1 [activation] NOTCH1 CACNA1A [activation] TP53 ARRB1 [activation] CCDC8 RAB14 [activation] PTN GSK3B [inhibition] APBB1 YWHAG [activation] ITGB1 CD47 [activation] KCNA5 KCNA2 [activation] PTX3 CFH [activation] DOK1 VAV1 [activation] GAB2 YWHAZ [activation] ASGR2 MROH5 [activation] APP CSNK1E [activation] ILK GLUD1 [activation] CD81 RPS15 [activation] ITGB2 PRKCB [activation] CETN3 HSPB1 [activation] INHBC INHBA [activation] SMAD2 CAD [activation;inhibition] LARP1 VCAM1 [activation] TRAF1 SRC [activation] ITPR2 TRPC4 [inhibition] SRPK2 CSAG1 [activation] CSF1 SOCS1 [activation] PPP2CB ITGA4 [activation] DIABLO BIRC5 [activation] APC HGS [activation] WAS TRIP10 [activation] PAXIP1 APP [activation] CDK5RAP3 UFM1 [activation] GATA1 NME1 [activation] STAP2 IKBKB [activation] FOXP3 NFAT5 [activation] PRKCB MBP [inhibition] PPP2CA APC [inhibition] RPA3 RFC2 [activation] ICT1 IGF2BP2 [activation] PSD HUS1 [activation] SSU72 MAPK9 [activation] PDPK1 PTPRC [activation] CCL2 VCAN [activation] ADCYAP1 SHH [inhibition] LYN MS4A1 [activation] SRPK1 KPTN [activation] PIAS3 SERPINA10 [inhibition] SRCIN1 CRK [activation] RXRB MBP [inhibition] PKNOX1 HOXB6 [activation] CDK1 PTCH1 [activation] STAT3 KAT5 [activation] HLA-B WDR48 [activation] DNM1L FIS1 [activation] CRY1 BTRC [inhibition] HNRNPA2B1 CTNNB1 [activation] FASLG CFLAR [inhibition] IGFBP4 IGF2 [activation] CLASRP DAB1 [activation] CCDC25 SMAD2 [activation] PDGFRA CAV1 [activation] SH3KBP1 PTK2B [activation] EGFR EHD4 [activation] 页 227 共 454


2016/4/8 19:14

JAK2 IL4R [activation] SH2D2A MAP3K2 [activation] SOCS3 CSNK1E [activation;inhibition] MAPK14 PI4K2B [activation] CSN2 GRB2 [activation] VCAM1 QARS [activation] CDC5L YWHAG [activation] CXCR4 MYBL2 [activation] CAMK2D WASF3 [activation] SRSF5 TNK2 [activation] CDC6 CDK1 [activation] ICT1 MRPL2 [activation] ATM ERRFI1 [activation] SMURF1 CAPZA1 [inhibition] MTNR1B GPR50 [activation] SRPK1 TCEAL2 [activation] AKT2 EGFR [activation] MDM2 XPO1 [activation] MKNK2 MAPK8 [activation] IGHA1 SERPIND1 [inhibition] HMGB1 HOXD10 [activation] YWHAZ HIST1H3A [activation] RHOA HSPA1A [activation] KMT2A CTBP1 [activation] POF1B ESR1 [activation] CDC42 CASP3 [activation] CHERP LRRK2 [activation] BTRC CASP3 [activation] RPLP2 TP53 [activation] DDX24 TPI1 [activation] HSP90AA1 NR3C1 [activation] RHOA RAP1GDS1 [activation;inhibition] CRKL KIDINS220 [activation] SHC1 KRT17 [activation] ST14 STK11 [activation] SMYD2 ASPM [activation] PRSS23 ACTG1 [activation] DDX54 ESR2 [activation] MAP3K5 EP300 [activation] PPP3CB GRB2 [activation] TRAF6 MAP3K8 [activation] PLAU MYC [activation] HSP90AB1 EIF4EBP1 [activation] TNFSF15 TNFRSF6B [activation] PIAS2 MYCN [activation] DAB1 VLDLR [inhibition] MAPK8 RPTOR [activation] CSK PLD2 [activation] FOS IDS [activation] TP53 PPM1G [activation] TGFBR1 ZFYVE9 [activation] DHX9 HLA-B [activation] MAPK6 RARA [activation] GCN1L1 VCAM1 [activation] ITPR2 TRPC1 [inhibition] MEF2A HAND1 [activation] MGEA5 MAST1 [activation] PPARGC1A UBE2I [activation] PTPN6 THEMIS [activation;inhibition] BARD1 MTA2 [activation] STAT3 PTK2B [activation] CDC5L KALRN [activation] SRPK1 SUMO2 [activation] RAPGEF2 FBXW11 [activation] MDFI SIX1 [activation] KMT2A CREBBP [activation] MMP9 COL4A3 [activation;inhibition] SERPING1 C1S [inhibition] CREBBP ATF1 [activation] HIST1H1B NSD1 [activation] SPTB MAPT [activation] SRPK1 MAOB [activation] SMC2 IKBKG [activation] EPN2 APOE [activation] VCAM1 PDCD10 [activation] FASLG SRGAP1 [inhibition] 页 228 共 454


2016/4/8 19:14

KPNA2 ITGA4 [activation] RAD17 RFC2 [activation] ADAM22 ABI2 [activation] DBP TEF [activation] GNAO1 TSHR [activation] CMAS LRRK2 [activation] GRB2 PTPN22 [activation] CTNNA1 SMAD1 [activation] HSPB1 GARS [activation] SOSTDC1 BMP4 [activation] SHPK MDM2 [activation] HSP90AB1 IRF2 [activation] HDAC1 STAT5A [activation] SHCBP1 PRKCB [activation] CREBBP TACC2 [activation] PTK6 EXOC5 [activation] PAXIP1 WDR18 [activation] RAB5C RIN2 [activation] NOTCH1 RANBP9 [activation] RAC1 ARHGDIG [activation] MTA2 TP53 [activation] TNK2 SRC [activation] PRKCI MAP1LC3A [activation] EP300 NFATC1 [activation] ITGA4 HBG1 [activation] RNF114 UBE2DNL [activation] LRP1 MMP17 [activation] ARF1 PLD1 [activation] PPARA SUMO1 [activation] MPP5 ARF6 [activation] TBRG4 MTMR4 [activation] DVL1 RB1 [inhibition] ATR XPC [activation] NOTCH1 PIK3CA [activation] CDK5 TP53 [activation] SLMAP PPP2CA [inhibition] FASN IGHG1 [activation] ACVR2B GDF11 [activation] BID CDC5L [activation] TCF12 CREBBP [activation] KCNAB1 KCNA5 [activation] MYC FANCI [activation] MYC HSPB1 [activation] PPP2R1A ERBB2 [activation] CD4 EIF4A2 [activation] MAPKAPK2 DDX5 [activation] MYCN CDKN2A [activation;inhibition] THRB PRKDC [activation] PHIP IRS1 [activation] IAPP COL25A1 [activation] MAPKAPK2 CDC25B [activation] ELN MMP7 [activation] MAP1LC3B DOK1 [activation] ABL1 ENAH [activation] SPECC1L APC [inhibition] ITGB2 GULP1 [activation] NXF1 GABARAP [activation] CALM1 KCNN3 [activation] HNRNPM HLA-B [activation] ANXA5 ISG15 [activation] NTRK2 NR3C1 [activation] HCK DNM2 [activation] PER3 CHEK2 [activation] JUP RAB8B [activation] C14orf142 TP53RK [activation] SMAD2 MECOM [activation] NXF1 FER [activation] ERH ILK [activation] TTBK1 CDK5R1 [activation] SMAD7 PPP1R15A [inhibition] NGB GNAI2 [activation] ATF2 AR [activation] PIK3R2 GRN [activation] YWHAB EPB41L3 [activation] ERLIN1 INSIG1 [activation] HIF1A HDAC1 [activation] 页 229 共 454


2016/4/8 19:14

CAST FYN [inhibition] MAST1 RNLS [activation] STYK1 HSP90AB1 [activation] EP300 SNW1 [activation] FBXW7 RICTOR [activation] DDR1 NCK2 [activation] RYR2 MDM2 [activation] LPXN MAP2K7 [activation] DNAJA1 RELA [inhibition] PIP5K1B PIP5KL1 [activation] HLA-G B2M [activation] RAF1 PDGFRB [activation] SIRPG CD47 [activation] FGFR1 NOSTRIN [activation] APP EIF2B2 [activation] KIF23 SH3KBP1 [activation] FBXW7 HRAS [activation] KDELR1 SERINC3 [activation] IGHG1 FCGR3A [activation] PRKACA CAV1 [activation] NUP153 MYC [activation] SREBF2 SUMO1 [activation] DNAJB1 COA3 [inhibition] TANK CBLB [inhibition] PPARGC1A NR5A2 [activation] ARPC2 OBSL1 [activation] HIST1H1C SMURF1 [inhibition] MMP2 CLDN1 [activation] OBSL1 HIST2H3A [activation] APP SRPK2 [activation] SMURF1 BTRC [inhibition] NSD1 RORA [activation] TGFBR1 RHOJ [activation] NEDD4 CASP3 [activation] GFRA1 NCAM1 [activation] RHOA PRKCZ [activation] EHD2 DDX56 [activation] TAGLN2 MDM2 [activation] CALM1 ADORA2A [activation] DDX47 PRNP [activation] RELA HSP90AA1 [activation] CR1 FUT4 [activation] GRB2 RPL21 [activation] TXN2 FAM9B [activation;inhibition] SORBS1 SMAD2 [activation] ANAPC11 FZR1 [activation] PPP2CA PPP2R5A [activation] HDAC1 SUV39H1 [activation] XPC ATM [activation] PRIM1 MOV10 [activation] INSR PTPRB [activation] SHANK1 ARHGEF7 [activation] NUDCD3 CFLAR [inhibition] IL36RN SSBP3 [activation] MARCKS CALM1 [activation] CASP8AP2 FADD [activation] RAB11A ME2 [activation] CST6 GSK3B [inhibition] OSR1 EGLN1 [activation] ABL1 NTRK1 [activation] MAP2K1 PEBP1 [activation] CCDC136 MOS [activation] MYO5B SMAD3 [activation] PLCB3 NXF1 [activation] TRAF6 STIP1 [activation] YWHAB SH3RF3 [activation] CD3E ZAP70 [activation] VCAM1 MYL6 [activation] RDH13 TP53 [activation] NR3C1 KPNA2 [activation] GNAI3 ELAVL1 [activation] HSPA4 PACRG [inhibition] GATA1 PRKAA1 [activation] SMAD4 RAB2B [activation] DNAJB7 SRPK2 [inhibition] RBM48 ANXA7 [activation] 页 230 共 454


2016/4/8 19:14

ANP32B STK11 [activation] GABARAP PRKCI [activation] GRIP2 GRB2 [activation] PLEKHB2 VSIG8 [activation] BAD WNK1 [activation] AURKB PHKB [activation] LYAR PRKRA [activation] DOCK2 FYB [activation] PRPF6 PHLDA3 [activation] SNAI2 PPP2R2D [activation] FGR CCR3 [activation] ERBB3 GRB7 [activation] RXRA GSK3B [inhibition] EGF S100A4 [activation] CEP350 MAPK1 [activation] YWHAB TSC2 [activation] CELSR3 FYN [activation] NRG1 CDC5L [activation] POLA2 APP [activation] YWHAZ HIST1H4A [activation] FYN NTRK2 [activation] CSF1 NOTCH2NL [activation] MDM2 CTBP1 [activation] CHEK2 CDH13 [activation] ANXA5 LAMC3 [activation] ITPR3 SIGMAR1 [activation] CREB3L2 GULP1 [activation] PPP2CA PDCD10 [inhibition] TIRAP SOCS1 [inhibition] ENAH APBB1 [activation] CCNA1 CSNK1E [activation] BCL2L1 SNCA [activation] ATG14 RALB [activation] REEP4 YWHAB [activation] MDK JAK2 [activation] IFI16 ICAM1 [activation] PIAS2 MX2 [activation] PVRL3 NOTCH2NL [activation] ATM PPP1CC [activation] MIF GABARAPL2 [activation] HIF1A TRIM28 [activation] ITGA4 HIST1H2BH [activation] CXCL10 IGFBP7 [activation] BACE1 FURIN [activation] HSP90AB1 PTK2 [activation] PRKCZ GLRX3 [activation] DDX58 NLRC5 [activation] ESR2 FTSJ3 [activation] TFDP1 CDC27 [inhibition] GNB5 RGS9 [activation;inhibition] BIRC2 MAP3K14 [activation;inhibition] SH2B1 FGFR3 [activation] HSPA8 HSPA2 [inhibition] YAP1 PARD3 [activation] GABARAP PFN1 [activation] TET2 YWHAH [activation] DUSP3 MCC [inhibition] MAP3K3 TRAF6 [activation] E2F1 BTG3 [activation] PRKDC YWHAB [activation] ARPC2 AURKA [activation] GYS1 CCDC36 [activation;inhibition] FRS2 CBL [activation] SOCS1 NCK1 [inhibition] PTPN6 PDGFRB [activation;inhibition] RB1 JUN [activation] GUCY1A3 IKBKG [activation] BUB1B MIS12 [inhibition] MAPK7 PML [activation] PBK RAF1 [activation] RASA3 HCK [activation] DARC CXCL1 [activation] TRAIP TNFRSF8 [activation] KAT2B SMARCB1 [activation] CAMK2B KRTAP19-5 [inhibition] NEK1 LRRK2 [activation] 页 231 共 454


2016/4/8 19:14

LRFN4 PPP2CA [inhibition] APP COL4A1 [activation] CTR9 HIST1H1C [activation] RPS6KA2 HSP90AA1 [activation] IRF7 SUMO1 [activation] MRPL40 HLA-B [activation] SRPK1 SAFB [activation] NMI IRF7 [activation] ALG8 RPS6KA5 [activation] EPX PIK3R1 [activation] SYTL3 RAB10 [activation] CD19 PLCG2 [activation] CCL18 TLE1 [activation] CD300LF PTPN6 [activation;inhibition] MAP2K3 MAP2K6 [activation] CCR7 CD247 [activation] WARS DDA1 [activation] ATR CREB1 [activation] CDC25B CREBBP [activation] SNAI1 NBN [activation] GHRHR MLNR [activation] GNAS PCK1 [activation] RAB14 APP [activation] ABL2 HCK [activation] HNRNPA1 RPA3 [activation] MYC SKIV2L [activation] PTPRC ANP32A [activation] RUNDC3B STK3 [activation] SIRT2 KAT2B [activation] GEM A2M [inhibition] HSPA1A EIF2AK2 [inhibition] PTPRM PPFIBP1 [activation] CCR5 CREB3 [activation] FEZ2 C16orf59 [activation] HSPB1 EHD1 [activation] NUDCD3 KLHL35 [activation] YWHAG AMOT [activation] CCNG1 MOV10 [activation] DIRAS2 CALM1 [activation] B4GALT1 TUBB [activation] NR4A1 RPS6KA5 [activation] ITGB2 PRKCH [activation] PPP4C PPP4R1 [inhibition] PTPN6 GHR [activation;inhibition] CDCA8 HIST2H3A [activation] EHD4 CDC5L [activation] CREB3 PLLP [activation] SRPK2 APOBEC3C [activation] PER1 PAXIP1 [activation] TNFRSF1B GRN [activation] PTPN6 TRAF6 [activation;inhibition] GORASP1 CASP3 [activation] HOXB8 MEIS1 [activation] MMP9 EPHB2 [activation] SP1 RUNX1 [activation] MDM2 RAB7A [activation] FBXO6 PPP6C [inhibition] RASSF1 SFN [inhibition] GMFG CAMK1D [activation] UFSP2 CAPN1 [activation] NXF1 SRSF1 [activation] ESR1 LCK [activation] HSP90AA1 IGF1R [activation] PTGDR2 ANKRD13C [activation] RSPO2 PLEKHF2 [activation] CEP250 ABR [activation] PIK3R1 DAB2IP [activation] CAMK2G LRRC7 [activation] POLD2 ERBB2 [activation] SRPK2 RTF1 [activation] LCP2 WNK1 [activation] CASP3 GRIPAP1 [activation] DHX15 ANXA1 [activation] PLCG1 SOS2 [activation] CCDC8 TP53 [activation] SRPK2 CHUK [activation] 页 232 共 454


2016/4/8 19:14

TTC38 PFDN1 [inhibition] DES MLH1 [activation] MYC TNFRSF18 [activation] ARHGEF6 RAC1 [activation] NOTCH2NL CTSG [activation] CACNB2 CACNA1C [activation] FABP1 GRB2 [activation] GRB2 RPL26 [activation] AAMP C8orf33 [inhibition] MYC C2orf16 [activation] DDAH2 VCAM1 [activation] CDK2AP1 POLA1 [activation] EPHB6 CRKL [activation] SNRNP70 MYC [activation] MADCAM1 CD44 [activation] AKT1 MTA3 [activation] USHBP1 BET1 [activation] LRPAP1 EIF4EBP1 [inhibition] SKP2 E2F1 [activation] LAMP2 RPTOR [activation;inhibition] RPA1 SMAD3 [activation] SHC1 PTPN2 [activation] JUNB MECOM [activation] SIGLEC11 PTPN6 [activation;inhibition] APP TNFSF13B [activation] NR4A1 RPS6KA1 [activation] PIAS2 TICAM2 [activation] SUMO3 STIM1 [activation] SERPINA1 CELA1 [inhibition] ADAM17 TNF [activation] CAMK1D TNFSF13 [activation] C1orf109 SPERT [inhibition] CALM1 ADD2 [activation] MYH3 DYSF [activation] CD19 PIK3R1 [activation] VAV1 ABL1 [activation] SNCA A1BG [activation] PRKCE PECAM1 [activation] BAK1 ARHGDIA [activation] BVES HSPB1 [activation] GORASP2 NUP62 [activation] TP53 SUMO2 [activation] S1PR3 GNA13 [activation] EEF2 WEE1 [activation;inhibition] PRKAA1 FNIP1 [inhibition] MDM2 BHLHE40 [activation] MAD2L1 DSTYK [inhibition] LYN SH2B2 [activation] PDHX CDKN1A [activation;inhibition] CSNK2B RPS6KA5 [activation] NR2F6 HSBP1L1 [inhibition] CRMP1 RPS6KA5 [activation] APP ART4 [activation] MYO1D ILK [activation] RFC4 VCAM1 [activation] ANAPC1 ANAPC7 [activation] FOSL1 EP300 [activation] TNFRSF1A CBL [activation] HSPA8 RAF1 [activation] PCNA EGFR [activation] CHD8 CTDP1 [inhibition] STAT1 POR [activation] ETS2 SRC [activation] DVL2 WWTR1 [activation] HIST2H2BE TAF1B [activation] PDIA2 GRB2 [activation] CBL CD19 [activation] F5 SERPINA3 [inhibition] NXF1 PCF11 [activation] CDK1 RAP1GAP [activation] MOGS AURKB [activation] ICAM1 ILF2 [activation] SYNPO2 WNK1 [activation] YWHAZ WWTR1 [activation] PIH1D2 MVP [activation] PTPRJ JAK2 [activation] 页 233 共 454


EGFR MYO10 SRPK2 DGKA EP300 MAPK7 MAPK8 SCN5A ACTN1 KMT2A BTG2 EVI5L RAB5A LRRK2 ADRBK2 LCK DMC1 AMOT BCL2L1 SUV39H1 RPAP3 MAP3K7 STAT5A BCL6 RXRB AHCYL1 SMAD4 BCR SMAD5 TRAF6 CDK11B YWHAZ DOK3 TRIP6 STK25 STAT1 RANBP9 RAB5A GSK3B CYTH4 GRB2 NCOA3 AKAP2 CDC16 SDC4 YWHAG MOB4 AURKB PRKCA NLRX1 UBTF DAPK3 CASP3 ICT1 RICTOR IGF2BP2 HSD17B4 GZMA PPP2CA HNRNPC PAXIP1 PGK1 DLG3 USP9Y TGFB1I1 RAD51B ROS1 CALM1 HSPA4 HTATIP2 NFE2L3 HEMGN ANXA1 HMGB1 TRPV1 IL21

2016/4/8 19:14

ATAD3B [activation] DCC [activation] BCE1 [activation] SRC [activation] EMB [activation] MYC [activation] EEF2K [activation] FGF13 [activation] CDK5 [activation] KMT2B [activation] FBXL3 [activation] A2M [inhibition] IKBKE [activation] CAPZA2 [activation] CXCR4 [activation] PTPRM [activation] TRIM23 [activation] PARD3 [activation] RBM5 [activation] C17orf82 [activation] EIF4A1 [activation] FOS [activation] LEF1 [activation] IDI2 [activation] PPARG [inhibition] BID [activation] BRCA1 [activation] WDR48 [activation] SUV39H2 [activation] UBE2M [activation] POU2F1 [activation] BCAR1 [activation] LRRK1 [activation] PRKAA1 [inhibition] ACACA [activation;inhibition] HSF1 [activation] NTRK2 [activation] ITSN1 [activation] RGS22 [activation;inhibition] KIFC3 [activation] RACGAP1 [activation] HIST1H4A [activation] PIK3R1 [activation] DAB2 [activation] CCL5 [activation] PFKFB2 [activation] EGLN2 [activation] CDC5L [activation] AKAP12 [activation] FASTKD5 [inhibition] TAF1C [activation] PPP1R12A [activation] HNRNPU [activation] MRPL9 [activation] DHRS7 [activation] MYC [activation] UBA5 [activation] HNRNPK [activation] RHO [activation] PDGFB [activation] WDR48 [activation] MDM2 [activation] SEMA4C [activation] MAPT [activation] SMAD7 [activation] XRCC2 [activation] EGFR [activation] MYC [activation] LIN37 [inhibition] ETS1 [activation] NFE2L2 [activation] DCC [activation] MAP1S [activation] HOXB1 [activation] CBL [activation] DGKA [activation] 页 234 共 454


2016/4/8 19:14

DDX47 MYC [activation] CTNND1 GRIK2 [activation] PRMT1 RUNX1 [activation] HLA-B GSPT1 [activation] ERBB2 UBASH3B [activation] TRAF4 PTK2B [activation] LRRK2 MYL6 [activation] SLA ERBB2 [activation] EPRS NXF1 [activation] PRKCI HRAS [activation] DDX39B TUBB4A [activation] MAP3K2 PIBF1 [activation] UBC PIK3CG [activation] MARK3 CPSF4 [activation] SH2B1 SH2B2 [activation] PLSCR3 PRKCD [activation] PPARGC1A USF2 [activation] SHC1 RASA1 [activation] LCK SMAD2 [activation] CSF2RB JAK2 [activation] CREBBP TP53 [activation] FASLG MMP7 [activation] SKP2 BTG2 [activation] HIPK3 TP53 [activation] MAPK3 TGIF1 [inhibition] WIPF1 HCK [activation] USF1 PLEKHF2 [activation] LRRK2 PRPSAP2 [activation] DNAJB5 SMAD2 [inhibition] SRC MAP4K1 [activation] FLNA DRD2 [activation] LIN37 MYL12A [activation] SRPK2 MARCH10 [activation] APP CRIP2 [activation] PTEN DBN1 [activation;inhibition] ATF2 PPIB [activation] ZBTB17 EP300 [activation] CRK TGOLN2 [activation] SIRT2 RELA [activation] GNB3 MTOR [activation] GSTK1 GRB2 [activation] PPP3CA ABL1 [activation] MCF2L GNB1 [activation] CEBPB EP300 [activation] SUV39H1 SRGAP3 [activation] EFHC2 EGLN3 [activation] HSPA2 TP53 [activation] SMURF1 NUDT5 [inhibition] CCDC114 C1orf216 [activation] DCDC2 APP [activation] YWHAB SLITRK1 [activation] LYN TNK2 [activation] IDE IFIH1 [activation] RASGRP3 PRKCQ [activation] KCNH1 FASTKD5 [activation] NCAPG SMC4 [activation] HSP90AA1 PLCE1 [activation] RAE1 KLRK1 [activation] SRPK2 ARRB2 [activation] MAP3K3 GNAI2 [activation;inhibition] YWHAB BID [activation] HSPA2 MAP3K3 [activation] NISCH GRB2 [activation] PTPN5 FYN [activation] PRKCB GCNT1 [activation] NGFR MAPK3 [activation;inhibition] UBE2I HSPB1 [activation] GRB2 IPO7 [activation] MLH1 NT5C3B [activation] RAB6B BMPR1B [activation] ESR1 SMAD3 [activation] CTNNA2 CTNNB1 [activation] PIK3R1 HDAC3 [activation] EHMT2 RD3 [activation] MAPK6 SHC1 [activation] SIRT6 SMC2 [activation] 页 235 共 454


2016/4/8 19:14

APOL2 AR [activation] TAB1 C2orf44 [inhibition] C1QA CR1 [activation] F9 LRP1 [activation] PSEN1 RHEB [activation] WAS FYB [activation] EIF4G1 MCC [activation] KNG1 PLAUR [activation] CDKN2A HRAS [activation] GAPDH EP300 [activation] MAPRE3 EIF4E2 [activation] ZAP70 SHB [activation] SPP1 BAG6 [activation] TRAF1 TNFRSF9 [activation] RRAGA CPSF3 [activation] PPIA OBSL1 [inhibition] MAPK3 BAZ1B [activation] HLA-B EEF1D [activation] FLT3 SOCS2 [inhibition] NCK1 C6 [activation] KRBA1 PLK1 [activation;inhibition] HSPA2 CDKN1A [activation] SRSF1 TP53 [activation] NTRK3 APP [activation] IRS2 PTPN11 [activation] TP53 NCOA3 [activation] GSK3B BAX [inhibition] TP53 DNAJA1 [inhibition] CDC42BPG RAC1 [activation] SNAI1 CHD4 [activation] CDC42BPB LGR4 [activation] MAGEB4 ROCK1 [activation] CRHR1 UCN3 [activation] DSG1 CCDC8 [activation] MKRN3 UBE2E2 [activation] C1QA CSPG4 [activation] NRIP1 RXRB [inhibition] FZR1 C7orf25 [inhibition] CCNB1 ANAPC11 [activation] FAM74A4 STX11 [activation] CSNK1A1 VCAM1 [activation] ADRB2 VEGFB [activation] HIST2H3A STAT1 [activation] EFS PLCG1 [activation] TP53 TTK [activation] GNPTAB MAPK1 [activation] EEF2 GRB2 [activation] PTPN11 MAP3K5 [inhibition] YWHAG MAP3K6 [activation] MAPK1 DYRK1B [activation] TPT1 CALM1 [activation] RRAGB APP [activation] APEX1 HLA-B [activation] LNX2 NUMB [activation] YWHAH CBL [activation] SIX4 SUMO2 [activation] IDE CCL3 [activation] WDR20 PHLPP1 [inhibition] GNB2 ATF2 [activation] BCAS3 PTPN1 [activation] CYTH2 APC [activation] CGN LATS1 [inhibition] SOCS3 YES1 [inhibition] CDC42BPB CDC42BPA [activation] TBL3 URM1 [activation] TP53 PATZ1 [activation] GRB2 WDR1 [activation] FANCC FANCF [activation] AATF MAPKAPK2 [activation] NFYC KIAA2018 [activation] AXIN2 CDC20 [inhibition] ERBB2 TXK [activation] EIF4E2 SPRY2 [inhibition] SCFD1 STX5 [activation] MMP14 MMP13 [activation] SUV39H1 SLFN12 [activation] 页 236 共 454


2016/4/8 19:14

GNB4 GNAI3 [activation;inhibition] MAPK3 GAB2 [activation] FOXO1 RFWD2 [activation] FARS2 ICT1 [activation] MAGEB2 SETD5 [activation] DAP3 PPARA [activation] SNCA CDK4 [activation] CSNK2B APC [activation] UNC13B STX2 [activation] TP53TG1 TP53 [activation] USP20 ADRB2 [activation] EDA LEPROTL1 [activation] PSEN2 CFLAR [inhibition] RPS16 MLH1 [activation] EPS8 GRB2 [activation] CASP3 DEDD [activation] OBSL1 SMARCA5 [inhibition] RIPK3 DNAJA1 [inhibition] RAI14 GRB2 [activation] KIAA1377 BARD1 [activation] NOXA1 NCF1 [activation] PAK2 HCK [activation] DNAJC3 PRKRIR [inhibition] HSP90AB1 MAP2K5 [activation] TBL3 EGFR [activation] NR2F1 RXRA [inhibition] HSPB1 MAP1LC3A [activation] PRKCZ EGFR [activation] DNM2 SORBS1 [activation] CNKSR1 BRAP [activation] ROBO2 ROBO1 [activation] SRPK2 MCOLN3 [activation] EVL RAD51 [activation] LYPD3 PALB2 [activation] MAPK3 MAP3K3 [activation] ELSPBP1 EP300 [activation] FAM122B MYC [activation] MDM2 CLPP [activation] ABL1 HSP90AB1 [activation] JUP NFKBIE [activation] SGTA CSF1 [activation] CASP8AP2 CASP8 [activation] LRRK2 CKAP5 [activation] CSNK1D KDR [activation] MAPK3 SREBF2 [activation] FBXL5 PLK1 [activation] LAD1 SFN [activation] CAMK2D CD5 [activation] MAPKAP1 PRKDC [activation] SCARB2 CAV1 [activation] TP53 DAB2IP [activation] MAPK15 PIGR [activation;inhibition] CDCA8 TTK [activation] F2RL1 ST14 [activation] ACTG1 ANXA1 [activation] CD4 CXCR4 [activation] TP53 ATRX [activation] NUP214 G3BP2 [activation] CDKN2AIP RPA3 [activation] TNFRSF14 RNMTL1 [activation] RPS6KA5 GPRASP2 [activation] PA2G4 UBA5 [activation] CD81 MME [activation] SPERT PLEKHN1 [activation] CSNK1D HN1L [activation] DDX10 G3BP2 [activation] ATF4 GTF2A1L [activation] PAK1 CAV1 [activation] SMAD4 FBXO34 [activation;inhibition] ANAPC7 SIRT6 [activation] RAB5A RAB37 [activation] HSPA6 NFKB2 [activation] PIK3R2 HSPA6 [activation] PTBP3 RAC3 [activation] USHBP1 RASAL2 [activation] SRSF3 SRPK2 [activation] 页 237 共 454


2016/4/8 19:14

TIA1 VCAM1 [activation] ANXA5 TERF2IP [activation] ARF6 RCC2 [activation] GRB2 CFL1 [activation] SMAD3 EIF4B [activation] ERN1 FBXL21 [inhibition] AGTRAP MUTYH [activation] NAT8 SMAD4 [activation] APP HSPG2 [activation] PTPN14 PPP2R1A [inhibition] TNFRSF1B SLC25A6 [activation] POLR2A CASP10 [activation] E2F1 RARA [activation] EP300 PTGS2 [activation] CDK5RAP2 TUBGCP5 [activation] CCNL2 CDK11A [activation] OTX2 CDK4 [activation] RBM48 HSPB1 [activation] KPNB1 NXF1 [activation] SLC9A3R2 WWTR1 [activation] NXF1 TRAP1 [activation] EGFR ADRBK1 [activation] GNG12 FHL2 [inhibition] NFE2L2 PGAM5 [activation] SRC EZH2 [activation] MOS SSX2IP [inhibition] NUP62 THAP1 [activation] KLRC4 TYROBP [activation] PIP5K1C BTK [activation] MDM2 PRRC2C [activation] DSG1 GABARAPL2 [activation] SHB IL2RG [inhibition] GABRB2 PRKCB [activation] IL24 ATM [activation] IL6ST CNTFR [inhibition] CSNK2B STAT5A [activation] PLCG1 TRAIP [activation] APOE CNTF [activation] STRN4 WNT7A [inhibition] HNRNPH2 MDM2 [activation] LCK PLCG1 [activation] TRAF6 NUMBL [inhibition] FST INHA [activation] HNRNPAB HIST3H3 [activation] GNAI2 TUBA4A [activation;inhibition] BMX BCAR1 [activation] NFKB1 NR4A1 [inhibition] LATS1 FSD2 [inhibition] IRF3 HERC5 [inhibition] TRIB3 RPGRIP1 [inhibition] F13A1 PLEK [activation] CCNG1 GRN [activation] MYC TKT [activation] KMT2D AR [activation] EPHA4 FGFR4 [activation] MAPK3 CREM [inhibition] MTOR LARS [activation] EPAS1 BATF2 [activation] GNAI2 CXCR2 [activation] ANXA7 PAAF1 [activation] SHC1 BCL3 [activation] SUMO1 CAMK2D [activation] SMAD3 RELA [activation] TCAP MSTN [activation] GDF9 CCDC53 [activation] FBXO9 MTOR [activation] STAT6 IFNAR1 [activation] SCAMP1 SNAP23 [activation] CCHCR1 EFHC2 [activation] SYK LCK [activation] RASSF8 PPP1CC [inhibition] LRRK2 CEP72 [activation] RIPK2 HSPA6 [activation] EIF3F HLA-B [activation] TSSK6 MBP [activation] BTK PLAU [activation] 页 238 共 454


2016/4/8 19:14

TERT PINX1 [activation] NXF1 LRRC42 [activation] NCOA1 NR4A1 [activation] FOSB JUNB [activation] GNAI2 CCR5 [activation] TRAF6 SOCS3 [inhibition] KPNA2 RGL2 [activation] APP VAMP3 [activation] FOXO3 GBAS [inhibition] ZNF207 MAP2K2 [activation] ADRB2 STAT4 [activation] SMAD3 MAPK14 [activation] ERO1L PELI2 [activation] WNK1 ZNF839 [activation] CXCL13 ACKR4 [activation] APBB1 ERBB2 [activation] BUB1B KAT2B [activation] CFL1 ARRB2 [activation] FYN FCGR2A [activation] MAFK HOXD12 [activation] BHLHE40 CDPF1 [activation] CCL26 CCR1 [activation] PPP1CC ANKRD42 [activation] RALGDS ARRB1 [activation] MAPKAPK2 HSF1 [activation] WDR18 ESR2 [activation] LYN CASP9 [activation;inhibition] MAP3K2 XIAP [activation] FASLG TEC [activation] MYC TEX2 [activation] CSF2RA FATE1 [activation] CALM1 PTH1R [activation] BCL2L1 TP53BP2 [activation] RFX7 IGHG1 [activation] DMC1 KCTD17 [activation] EGFR GGCT [activation] NTPCR VCAM1 [activation] MAPK14 CAMKK2 [activation] FASN MAPK3 [activation] MEIS2 APP [activation] PML CDK1 [activation] EIF1AX EIF5B [activation] CSNK2A1 ACACA [activation;inhibition] NXF1 SFXN3 [activation] GCNT1 RSU1 [activation] ITGB1 ITGA2 [activation] ARRB2 HTR2C [activation] ATP2B4 SRC [activation] C3 MASP1 [activation] SUMO3 KIF23 [activation] TRAP1 APP [activation] SH2D3A GAB1 [activation] RGS13 PRKACA [activation;inhibition] ARL5A KPNA2 [activation] CP IGHG1 [activation] RALGDS LRPAP1 [inhibition] CXCR1 CDK1 [activation] RAD21 ACTR3 [activation] BATF2 ATF4 [activation] SNCA CALM1 [activation] HNRNPA1 APP [activation] TRAF6 HSPA1L [activation] H3F3A ITGA4 [activation] PARD6A CRB3 [activation] NDRG1 SLC25A6 [activation] SMARCD1 HSPB1 [activation] PPM1A CTNNB1 [activation] TRAP1 TNFRSF1A [activation] BCL6 CACNA1A [activation] SF3B4 FYN [activation] HDAC3 BUB1B [inhibition] YWHAZ MAP3K4 [activation] CASP6 UBE4B [activation] TP53 MTHFSD [activation] PSEN1 EFHD1 [activation] CORT SSTR3 [activation] 页 239 共 454


2016/4/8 19:14

RNFT1 NXF1 [activation] CDK4 PPP1CC [inhibition] MAPKAPK3 DCC [activation] PPP2CA TRAF3IP3 [inhibition] WDR33 TGFBR1 [inhibition] CALM1 NR3C1 [activation] GLRX5 HLA-B [activation] ABL1 GSX2 [activation] RAD21 APOB [activation] PAK2 SORBS3 [activation] CDC42 WASF2 [activation] PAK1 SORBS3 [activation] VAPB STX4 [activation] PPP1R9B GRB2 [activation] GABARAP NUP88 [activation] MCM2 PYHIN1 [activation] SYK LAT [activation] TRPV4 KRIT1 [activation] PRDM7 TRAF1 [activation] ATG14 PIK3C3 [activation] SRPK1 HIRIP3 [activation] JAK3 CCT8 [inhibition] GRB7 A1BG [activation] RHPN2 CNKSR1 [activation] EIF4A1 CHD1L [activation] BRCA2 PLK1 [activation] C2 C3 [activation;inhibition] MAFK SMAD3 [activation] MDM2 RPS6 [activation] ABL1 TERT [activation] BCL2A1 NR4A1 [inhibition] PAFAH1B3 BRD7 [activation] SUPT5H HSPB1 [activation] CYTH3 FRMD4B [activation] TDRD1 FYN [activation] KIT SH2D1A [activation] INSIG1 SREBF2 [activation] APLP2 ETS1 [activation] CCDC70 FAM9B [activation] FGFR1 HSP90AB1 [activation] EP300 RXRA [inhibition] PARD6G CDH5 [activation] AMBP ENO1 [inhibition] C9orf78 MAPK11 [activation] EGFR ZAP70 [activation] EDAR TRAF3 [activation] RAD51 FANCD2 [activation] CREBBP BCL3 [activation] DTX3L UBE2E2 [activation] ADAM22 LYN [activation] RAC1 PIP4K2A [activation] KLRD1 KLRC1 [activation] NUDT3 CCL11 [activation] IGF1R CAV1 [activation] GOSR1 DSC1 [activation] FGFR2 FRS2 [activation] PRKCZ YWHAH [activation] CYTH2 GRB2 [activation] GNA13 GPR17 [activation] RAB35 LATS1 [inhibition] CORO1C DAPK1 [activation] ATG5 GSTM3 [activation] CAMK2B CCM2L [inhibition] KIFC3 NUP62 [activation] GRB2 GRB7 [activation] STAT3 ALK [activation] PIK3R1 DARS [activation] VCAM1 FARSB [activation] EP300 NR2F2 [activation] TP53 ZNF24 [activation] EPS15L1 VCAM1 [activation] SYK TLR4 [activation] CNTFR CRAMP1L [inhibition] AURKA JTB [activation] FAM173A TP53 [activation] GRB2 CCL5 [activation] 页 240 共 454


2016/4/8 19:14

NXF1 CAV1 [activation] TERT SMARCA2 [activation] CS NXF1 [activation] LIMK1 MBP [activation;inhibition] PHF13 SUMO3 [activation] ITPA EGFR [activation] TBK1 HMMR [activation] ARPC5 LRRK2 [activation] MARCH1 TFRC [activation] RUNX1 VDR [activation] TGFBR2 CD44 [activation] PTPN6 FCGR2B [activation;inhibition] MAP2K3 MAPK3 [activation] APP IER3 [activation] DIRAS3 STAT3 [activation] SIRT1 DVL1 [activation] TP53 TOP2A [activation] NDUFAF7 LRRK2 [activation] MAPK14 SLC12A2 [activation] PPP1CA TP53 [activation] RAC1 CASP3 [activation] TUBB4A RIPK1 [activation] WDR89 PHYHIP [activation] SORBS1 YWHAB [activation] BHLHE40 PRKAA1 [activation] SORBS2 VCL [activation] LYN ERO1L [activation] CD163 PRKCA [activation] ANAPC5 TFDP1 [inhibition] VCAM1 CAPNS1 [activation] BHLHE41 BHLHE40 [activation] VDAC1 CYCS [inhibition] ATM TRAF6 [activation] HSF1 SUMO2 [activation] APC FAM214A [inhibition] RAB18 EGFR [activation] TP53 SKP1 [activation] MAP3K3 YWHAH [activation] SRPK1 SPATS2 [activation] ABI2 CCDC102B [activation] KMT2A CSNK2A2 [activation] OPRL1 PNOC [activation] PTPRE PTPRS [activation;inhibition] C16orf78 SRPK2 [activation] CAV1 APP [activation] TCF19 NGFR [activation;inhibition] ARF6 POLD1 [activation] UBXN7 APP [activation] EIF4A3 PPM1B [activation] LRRK2 AFG3L2 [activation] IRS2 CRK [activation] SKIV2L2 RPA3 [activation] FBXO44 C17orf59 [inhibition] CCDC102B PNMA5 [inhibition] DUSP1 CKS1B [inhibition] NCL STK4 [activation] PPP2R5A PTTG1 [activation] MAPK14 GADD45A [activation] CEBPA FOS [activation] PLD1 RAC1 [activation] HSPB1 MYLK [inhibition] PRKCI NIPSNAP1 [activation] TP53 AXIN1 [activation] HLA-B PLS3 [activation] HRH4 CCL16 [activation] SRPK1 ODF3L2 [activation] HEATR1 MYC [activation] MAP1LC3A EGFR [activation] MEN1 RPA1 [activation] FOS YWHAB [activation] STAT6 TBK1 [activation] EP300 GATA4 [activation] SMPD2 PIK3CG [activation] S100B MDM2 [activation] MADD WNK1 [activation] EGFR PUS1 [activation] 页 241 共 454


2016/4/8 19:14

CRK GP9 [activation] MBL2 MASP1 [activation] PIK3R2 LAMB2 [activation] BMPR1B AMHR2 [activation;inhibition] SMURF1 TRIB2 [inhibition] PTPRB PXN [activation] NOS2 SERPINE1 [inhibition] ANAPC7 EP300 [activation] TAOK1 MST4 [activation] ITPR1 FKBP1A [inhibition] SGK2 APP [activation] LAT GRAP [activation] DIAPH1 BAIAP2 [activation] EGFR CDC25A [activation] CDK5R1 ODF1 [activation] HSP90AB1 CD4 [activation] MDC1 RECQL5 [activation] ETS1 PAX5 [activation] VCAM1 PPP1CA [activation] MTOR PPP2R2A [activation] TNK1 SFN [activation] SYMPK HSF1 [activation] RHOA PITPNM1 [activation] YWHAB KIAA1671 [activation] GNAI2 SUMO2 [activation;inhibition] ANXA5 TERF2 [activation] KCTD12 ATG5 [activation] ACACA CBL [activation;inhibition] CEBPA TGFB2 [activation] ERRFI1 PALB2 [activation] KIT SOCS6 [inhibition] SERTAD1 CREBBP [activation] ALOX15B RXRA [inhibition] NCOA2 NCOA3 [activation] TP53 WDR77 [activation] LAT PTPN1 [activation] KCNJ3 GNB1 [activation] OGN SRC [activation] RB1 PRKCB [inhibition] HSPA8 ATM [activation] PRKRIR EIF2AK2 [activation] CD53 PRKCA [activation] VDAC3 ATF2 [activation] HMMR CD44 [activation] FCAR PILRA [activation] YWHAZ MVP [activation] FANCA GRB2 [activation] FAIM2 STK11 [activation] ICT1 NME4 [activation] CEBPG DDIT3 [activation] SPP1 PEMT [activation] TREX1 ATR [activation] POLR2A RECQL5 [activation] MZT2B CDK5RAP2 [activation] SMAD2 NFYC [activation] GRB2 SLCO2A1 [activation] PAFAH1B1 NDEL1 [activation] CASP1 IL33 [activation] MSH4 MLH1 [activation] RAPGEF4 RRAS2 [activation] APOE PSEN1 [activation] POLR3GL CCND3 [inhibition] ARHGDIA TWF2 [activation] ZBTB7B GRB2 [activation] STK4 MBP [activation] CAMK2A SRF [activation] CCDC137 MPP3 [inhibition] DBNL MAP4K1 [activation] GSK3B CEBPA [activation;inhibition] ATF7IP LAMA5 [activation;inhibition] OBSL1 IGF2BP1 [activation] PRKACA EGFR [activation] BRCA1 MLH1 [activation] CASP4 ELF4 [activation] SGK2 IL3RA [activation] ASB5 DNAJA1 [inhibition] 页 242 共 454


2016/4/8 19:14

TRIP10 RHOQ [activation] GRB2 DLGAP1 [activation] EHD4 RASGRF1 [activation] ZNF76 PIAS1 [inhibition] PBK CDK1 [activation] FGG ASB7 [activation] PRTN3 CAMP [inhibition] PLXNB2 PLCG1 [activation] PPP3R2 PTPRJ [activation] HNRNPA2B1 TP53 [activation] EGLN1 HIF3A [activation] FANCD2 MEN1 [activation] VCAM1 PUM1 [activation] PRKAA1 NOTCH1 [activation] GRB2 CFH [activation] EP300 SKP2 [activation] FGFR1 STAT3 [activation] PVR NOTCH2NL [activation] TMEM45B TINAG [activation] FAM124A STAC3 [activation] HSPB1 CDC123 [activation] PTPRC TEK [activation] APP CTNNB1 [activation] DYSF COL12A1 [activation] FGF21 MAPK7 [activation] VAV3 LCP2 [activation] BCL2L1 BLID [activation] BRD7 KIAA1377 [activation] GNB2 GNGT1 [activation] ASB16 RAN [activation] SMYD3 TRIT1 [activation] CREB1 GLI2 [activation] NR3C1 MED1 [activation] ASPM GPRASP2 [activation;inhibition] APOE FBXL12 [activation] PTPN11 RET [activation;inhibition] VCL PTK2 [activation] ABL1 YWHAE [activation] DDX21 GABARAP [activation] DYRK1A PRKACB [activation] EGLN3 HIF3A [activation] FOS ZMYM6 [activation] SMAD3 EPB41L5 [inhibition] HSPG2 PYHIN1 [activation] FAS CASP8AP2 [activation] RPL31 ICAM1 [activation] LTK PTPN1 [activation] NAPA VAMP8 [activation] AIRE XPO1 [activation] XPO1 PPARG [activation] PSG9 SMAD4 [activation] MAPK1 BCL6 [activation] ITCH CYLD [inhibition] CHD8 CHD7 [activation] WNK1 PVR [activation] GLS PARD6A [activation] GADD45A FAS [inhibition] ARHGAP5 RASA1 [activation] CCNC SOCS2 [inhibition] APEH HLA-B [activation] PRNP AIFM3 [activation] PRKCI MAP1LC3B [activation] BET1 STX4 [activation] IGFBP7 INHBA [activation] CDX2 CDK2 [activation] RAPH1 VASP [activation] CRK GAB2 [activation] NOS3 GUCY1B3 [activation] AGER RHOA [activation] CDK5 RNF32 [activation] FCGR1A SYK [activation] ELK1 MAPK9 [activation] SERPINE1 PTBP3 [inhibition] CD3D CD8A [activation] VPS33B ZAK [activation] ABL1 CREB1 [activation] 页 243 共 454


2016/4/8 19:14

ATG5 GABARAPL2 [activation] STAT1 PRMT1 [activation] PFDN1 PLXNB2 [activation] CAPZA3 ACTG1 [activation] IRAK3 ADH1B [inhibition] H2AFX PGK1 [activation] FYN TRAIP [activation] FOS JUNB [activation] IL1RAP IL1R1 [activation;inhibition] KALRN GNB1 [activation] NFKBIA SPRR3 [activation] SRPK1 OCEL1 [activation] ALS2CR11 SSSCA1 [activation] C1orf123 CDKN1A [activation;inhibition] KITLG PIK3CD [activation] WEE1 FBXW11 [inhibition] RPA3 LIMCH1 [activation] ASAP1 PXN [activation] HRAS SMAD4 [activation] U2AF2 SMAD2 [activation] SHC1 MOV10 [activation] TULP1 GRB2 [activation] AGTRAP ZFYVE21 [activation] PPP1CA PPP1R3B [activation;inhibition] TP53 RPL11 [activation] IGHD CD19 [activation] RRN3 UBTF [activation] HSP90AA1 PTK2B [activation] ANAPC2 HSP90AA1 [activation] SRC AR [activation] ABL1 CD19 [activation] ARFGEF2 GABRB1 [activation] SPARCL1 PRNP [activation] CR2 C3 [activation] KAT2B IRF1 [activation] CLIP4 TULP3 [activation] PRKAA1 BRSK1 [inhibition] ANXA7 NGFR [activation] ABCC5 SMC2 [activation] EPS8L1 ACTG1 [activation] KDR TXNIP [activation] ACTR2 CTTN [activation] SMARCA4 STAT3 [activation] CD47 FAS [inhibition] CSK PECAM1 [activation] RBPJ KDM5A [inhibition] FRMPD4 MYC [activation] VIL1 JAK3 [inhibition] HLA-B TXN [activation] NXF1 SMARCE1 [activation] S1PR1 HTR1D [activation] EPHA8 PIK3CG [activation] PPP2R1A LRRK2 [activation] YWHAB CDK16 [activation] VPREB3 VPREB1 [activation] KRT40 HCK [activation] FOXH1 AR [inhibition] UBE2D2 TRAF6 [activation] GNAI1 DRD3 [activation] SRC EPOR [activation] TXNRD1 DMRTC2 [activation] HSP90AA1 BCR [activation] GNB1 GNGT2 [activation] EGR1 CTNNB1 [activation] FNBP4 PLXNA2 [activation] CDK1 DAB2 [activation] KIF20A RAB6B [activation] CTSB IGF1 [activation] CALM1 NFKB2 [activation] PML HHEX [activation] MET BLK [activation] FHL2 SMAD4 [activation] BTK GAB1 [activation] HSPA4 BCL3 [activation] CLK1 PTPN1 [activation] HMGN1 PRKCA [activation] 页 244 共 454


2016/4/8 19:14

CTU1 URM1 [activation] CSF2 PABPC1 [activation] CNPY4 TLR4 [activation] CDK5RAP3 CREBBP [activation] EIF4EBP1 LATS1 [inhibition] MOB3A LATS1 [inhibition] SMAD3 PTPN6 [activation;inhibition] LNX2 PIK3R3 [activation] UBE2V1 SUMO4 [activation] MAP3K14 RIPK1 [activation] PRC1 PLK1 [activation] TUBB ZAP70 [activation] RABGAP1 TP53 [activation] ADRB2 CD4 [activation] SNX9 WAS [activation] PFN1 CMA1 [activation] CHRD NOTCH2NL [inhibition] RAP1B ZNF135 [activation] KMT2A AFF4 [activation] PICALM SIRT1 [activation] NUP210 ITGA4 [activation] EGLN3 OS9 [activation] MED27 RBPJ [inhibition] PAXIP1 CATSPERG [activation] HLA-B AASDHPPT [activation] YWHAB SNCA [activation] CDK4 HSP90AA1 [activation] RAD50 USP53 [activation] ZBTB7A SOX9 [activation] SRC DOK2 [activation] KMT2C MAPK14 [activation] OSTF1 SRC [activation] SRPK1 LYAR [activation] EGFR PPP2R5E [activation] ENG ACVR2B [inhibition] VCAM1 IGHG1 [activation] STAT5B APP [activation] NR3C1 LCK [activation] USP11 RAD50 [activation] FGD1 CTTN [activation] ANXA1 RIPK1 [activation] FCHO1 SMURF1 [inhibition] SMARCAL1 RPA3 [activation] ACTB HSD17B4 [activation] MDH1 TP53 [activation] PRPF8 ICAM1 [activation] PRG2 CSF2 [activation] ANAPC10 TP53BP1 [activation] ACTR2 CD44 [activation] SMAD1 PLEKHB1 [activation] MCM3 RAD52 [activation] MYC SHOC2 [activation] HK1 ENO2 [activation] PRKACB ARFGAP1 [activation] CAPNS1 GNB2 [activation] FBXO31 PARD6A [inhibition] RACGAP1 ARF6 [activation] AURKA UBE2N [activation] NCOA1 SUMO1 [activation] BMPR1B TTC27 [activation;inhibition] CREBBP NR5A1 [activation] CHEK2 CCL5 [activation] HMGN3 SMAD2 [activation] STRN3 STK4 [activation] CD5 PRKCA [activation] YWHAQ TNF [activation] PLG MAPK14 [activation] PPP2CA PXN [activation] RXRA ESR2 [inhibition] STK38 YWHAB [activation] SMARCA4 KPNA2 [activation] MLLT4 PVRL4 [activation] EIF2S1 PPP1CC [activation] ETS1 UBE2I [activation] ARPC3 ITGA4 [activation] PFDN1 EIF4A2 [activation] 页 245 共 454


2016/4/8 19:14

PFN1 ATF2 [activation] PAK2 MKNK1 [activation] AURKA LEF1 [activation] NOTCH1 MDM2 [activation] SHC1 ARHGEF5 [activation] KPNB1 SRY [activation] KDR FRS2 [activation] LATS1 RASSF1 [inhibition] HNRNPH3 CCL13 [activation] XRCC2 MEOX2 [activation] MDM2 TRIM4 [activation] DSCAM PAK1 [activation] CACNA1A WBP1 [inhibition] CRKL WAS [activation] CDCA8 SGOL1 [activation] PPP5C MAPT [activation] PTGDR APP [activation] RAC1 RPS6KB1 [activation] PDIA2 PLCG1 [activation] AURKB CBX3 [activation] RANBP9 L1CAM [activation] EPHB2 SH2D3C [activation] EIF4EBP1 UBAC1 [inhibition] NR3C1 ALDH5A1 [activation] UBE2R2 PNPLA2 [activation] BUB1B HDAC1 [inhibition] PIK3R1 CD2AP [activation] MCM7 GABARAPL2 [activation] MAP3K4 BUB1B [inhibition] CADPS2 UBE2E3 [activation] FGFR2 CBL [activation] MYOD1 PRKCA [activation] CAV1 KCNN3 [activation] CDK5R1 HDAC1 [activation] PPP2CA SGOL2 [inhibition] ITGAV PAK4 [activation] HSP90AB1 CHUK [activation] ITK HSP90AB1 [activation] TIFA TRAF6 [activation] STX6 NXF1 [activation] SDC3 ARRB2 [activation] CPNE1 YWHAZ [activation] EP300 NUTM1 [activation] ATR HELQ [activation] CREBBP PRKCD [activation] BMX FAS [activation] NR4A1 PPBP [inhibition] BRCA1 JUN [activation] PTPRA HSPB1 [activation] PTK2 CSPG4 [activation] KCNB1 SNAP25 [activation] CDKN1A GNB5 [activation;inhibition] BCL6 PIKFYVE [activation] SMAD2 PCID2 [inhibition] NOV CTGF [activation] NGFR RTN4R [activation] PRDM5 EHMT2 [activation] TRDN RYR1 [activation] NFE2L2 UBE2E3 [activation] NR4A1 MAPK8 [inhibition] UBE2F STAT1 [activation] PPP2CB HLA-B [activation] IKBKB IKBKAP [activation] NCOA1 CCND1 [activation] SLC12A6 OXSR1 [activation] ERBB3 S100A10 [activation] RPA4 RPA2 [activation] SREBF2 TP53 [activation] PPP2R1A CCDC6 [inhibition] OBSL1 RPL7L1 [activation;inhibition] CSNK1E NCOA3 [activation] CCL20 TGFB3 [activation] VPREB3 IGHM [activation] TP53 ACTB [activation] HSD17B4 PTBP3 [activation] DDX5 IL7R [activation] 页 246 共 454


2016/4/8 19:14

MSI2 VCAM1 [activation] TRAF2 LTBR [activation] CAPZB MDC1 [activation] NRXN1 NLGN2 [activation] CIAO1 POLA2 [activation] SH2D1B KIT [activation] SCD MYC [activation] GABARAP PRKDC [activation] ITGA5 ANGPT1 [activation] FAM133A STAC3 [activation] BMP5 CHRDL2 [activation] FYN SH2B2 [activation] F8 F10 [activation] HSPA8 PPP2R1A [inhibition] IQGAP1 VCAM1 [activation] ACACA MLLT1 [activation;inhibition] DGKD PRKCA [activation] PIK3R1 CSDE1 [activation] ARF1 FBXW8 [activation] CSF2 KITLG [activation] TGFB1I1 PTPN12 [activation] CASP5 PPHLN1 [activation] TRIM24 PML [activation] CDK4 SMC3 [inhibition] ABL1 EIF2A [activation] LRRK2 TEX33 [activation] TP53 VPRBP [activation] FZR1 E2F1 [inhibition] NEDD4 CBLB [inhibition] GNAI2 TBXA2R [activation;inhibition] GABARAPL2 TTBK2 [activation] TP53 RPS6 [activation] EGFR IDH2 [activation] THRB PPARGC1A [activation] STAT6 ETS1 [activation] HNRNPD EIF4G1 [activation] HCK APP [activation] DDX39B STRN4 [activation] VAV2 ERBB3 [activation] PTK2B HSP90AB1 [activation] ABI1 NIN [activation] TP53 LAMA4 [activation] CSF1R FYN [activation] ABL1 TP53 [activation] F9 F7 [activation] BARD1 CSTF2 [activation] TNK2 WAS [activation] PRKCI YWHAZ [activation] TAS1R3 TAS1R2 [activation] EZH2 AR [activation] GNAS FSCN1 [activation] MAP2K6 MAP2K4 [activation] WIPF3 GRB2 [activation] SUV39H1 MDM2 [activation] VCL SORBS1 [activation] NCK2 CD3E [activation] WHSC1 HNRNPA1 [activation] MEP1A KNG1 [activation] ECH1 STAT3 [activation] MEIS1 HOXD4 [activation] GMPS ITGA4 [activation] YWHAZ PDE1A [activation] GNAI3 S1PR1 [activation] KALRN SNCAIP [activation] ICK APP [activation] PARD6B YWHAB [activation] MMTAG2 EPB41L3 [activation] PDGFRB SYNGAP1 [activation] JUN SARS [activation] MAPK1 TNIK [activation] CAMKV HSP90AB1 [activation] PPP1CC EIF2A [activation] BAX ERN1 [inhibition] SIM2 NUDCD3 [activation] CASC1 BARD1 [activation] TERT TPP1 [activation] 页 247 共 454


2016/4/8 19:14

VAV3 KIT [activation] VCAM1 EIF3D [activation] MRPS27 ERBB3 [activation] ZFYVE9 SUPT5H [activation] SLAMF1 PTPN11 [activation] XPO1 HSP90AB1 [activation] ATF4 BATF [activation] MARK3 PRKCQ [activation] AURKB FZR1 [activation] ARID1A TP53 [activation] FASN RAD21 [activation] RGS1 GDE1 [activation;inhibition] GRAP2 MAP4K1 [activation] KRT33A GRB2 [activation] ABL2 CDC37 [activation] GSK3B GPR39 [activation] CSMD2 CRK [activation] A2M SHBG [inhibition] LUC7L2 HDHD2 [activation] TSPAN4 ITGB1 [activation] LAS1L ESR2 [activation] SUMO3 FOS [activation] CCL22 CRYAB [activation] PRKCD GABRA1 [activation] MPP6 SMARCA4 [activation] HOXD12 CREBBP [activation] LSP1 MAP2K1 [activation] FTSJ3 GABARAPL2 [activation] CSNK2A1 MAPK14 [activation] COMMD8 NFKB1 [activation] CBL ARHGEF7 [activation] FER ERBB2 [activation;inhibition] NUMB PRKCB [activation] GRB2 SIRPA [activation] EFNB1 ERBB2 [activation] BLK EEF1E1 [activation] CAMLG TRAF6 [activation] SPTAN1 STK4 [activation] STAT5B CCR5 [activation] EIF2S2 SUMO3 [activation] PPP1CC PCNA [inhibition] ESR2 WNK4 [activation] MLLT4 LGR4 [activation] NLK CUL1 [inhibition] RHNO1 GOLGA2 [activation] ERLEC1 STK11 [activation] PRRC2B IRF4 [activation] EPHB1 PXN [activation] LILRB2 HLA-C [activation] TP73 RCHY1 [activation;inhibition] MITF TFE3 [activation] CALM1 MYO10 [activation] CASP1 BCAP31 [activation] TTK RPS6KA1 [activation] RGS10 ACP6 [activation;inhibition] HSPB1 GRIPAP1 [activation] SHANK3 PLCG1 [activation] CAMK2B MORF4L1 [activation] RARG SPHK1 [activation] FBXO6 LAMB1 [inhibition] NSMAF GABARAPL2 [activation] SHC1 PLCG1 [activation] SOCS1 CRK [inhibition] MYC NFIL3 [activation] LAT PLCG1 [activation] EHMT2 E4F1 [activation] CD40LG IGKC [activation] PAFAH1B1 NUDC [activation] NOTCH1 NOV [activation] THOP1 EGFR [activation] VCAM1 HNRNPM [activation] CCKBR GRB2 [activation] YTHDF3 RPA1 [activation] NR0B2 PPARG [activation] WASL CD44 [activation] ABL1 AIRE [activation] 页 248 共 454


JAK1 CCR5 LYN PECAM1 FOXO1 SRC CHEK2 BRCA2 MYC MFGE8 PARD6G LLGL2 GNAT1 UNC119B ACTG1 VIL1 PRKCQ WIPF1 ENO1 VCAM1 SPRY1 GRB2 IKBKE CYLD MMP13 TIMP3 RAD21 EVL GRB2 DCTN2 SMC2 SUMO2 PHLDA3 SMC4 PGR ZBTB17 PPAP2C MLH1 TP53 ANXA3 ACTN1 PSEN1 ATF2 ERP29 CDC23 ATRIP CACNB2 REM1 PSIP1 PPP2R1A FAS FADD LNX2 TRAF2 OTUD4 STAT1 ACTN4 BMP7 FOS GATA3 TNFRSF11A TMX1 ATF2 RPL38 HLA-B PRKDC CHEK2 TP53 PARP1 TGFBR1 CHN1 GRB2 WBP11 GHR NCK1 GRB2 ESR1 ICT1 MRPL16 GOLGA2 PPP2CA HMGA2 PRMT6 SMAD3 SUV39H1 ZFP36 TFRC PPP2R1A PACSIN1 TNFSF11 NFKBIA ULK2 CREB1 TNS3 MET NUP214 ITGA4 ATF2 BSG CREBBP ACVR1 ARHGEF11 AURKB TP53 ATM TPT1 NDP BAG3 MMP9 CXCL1 RNF10 UBE2E2 CCDC59 ILK CSK ADRB2 MYOD1 JUN HNRNPL EIF2B1 HSPA5 EIF2AK3 ITGB2 ITGAX RDH12 ANXA8 YPEL2 SRPK2 MTUS2 HCK FYN GP6 MLH1 ATAD3B SMAD6 MAPK6 RPS6KA5 RELA RAB6B RPA3 PRDX2 CA4 ZNF598 RPA3 NUDCD3 TSSC1 SRSF10 SREK1 SGK1 IGHA1

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[activation] [activation] [activation] [activation] [inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] TRAF1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] LPAR2 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 249 共 454


2016/4/8 19:14

BTK PRKCA [activation] HSP90AB1 STK33 [activation] C1orf216 CEP170P1 [activation] IGFBP3 RXRA [inhibition] STK4 GABARAP [activation] JUN PRKD1 [activation] PLG PRNP [activation] CDK4 MTFP1 [inhibition] CDKN1A STAT3 [activation] EMILIN1 CDC23 [activation] DDX21 SRPK2 [activation] RHOC CAV1 [activation] PLCG1 EXTL3 [activation] CBL ABI1 [activation] MECOM SMAD1 [activation;inhibition] EDN2 KEL [activation] YKT6 USO1 [activation] PTPRB CDH5 [activation] EFNB2 RHBDL2 [activation] MEN1 CHEK1 [activation;inhibition] GHRH DPP4 [activation] TANGO6 MACF1 [activation] AMBP F2 [activation] GABARAPL2 EZR [activation] CBLB GRB2 [activation] RPA2 EIF4G2 [activation] HLA-E KLRC1 [activation] PIAS1 PTK2 [activation] RPTOR RPS6 [activation] MAPK6 CCND3 [inhibition] GRM5 PRKCQ [activation] PRKCB SDC2 [activation] SPTBN1 MAPK14 [activation] GNB2 CDKN1A [activation] ARAP1 VCAM1 [activation] RECQL5 CREB1 [activation] NFKB1 ANXA4 [activation] BMP7 ACVR2B [activation] IL27RA MAPK8 [activation] SMYD3 HSP90AA1 [activation] TOMM70A HSPA1A [inhibition] MAPK1 ATF2 [activation] RIPK1 NUMBL [inhibition] CUL1 CHEK1 [inhibition] SHARPIN ITGA1 [activation] WASF1 BAD [inhibition] PKN2 AKT1 [activation] DOPEY2 EGFR [activation] ITGA4 RPS24 [activation] BARD1 BEND3 [activation] CD3E PTPN22 [activation] AXIN1 SKIL [activation] PVRL3 PVRL1 [activation] RELA TRIB3 [activation] MAPK1 SHANK3 [activation] HSPB1 STAT2 [activation] MRPL39 TP53 [activation] EPHB2 PTP4A2 [activation] KPNA2 CHEK2 [activation] TP53 CSNK2A2 [activation] SMURF1 GNG11 [inhibition] ADRB2 DLAT [activation] NXF1 EIF1AD [activation] SGK223 HSP90AB1 [activation] AMOTL1 LATS1 [inhibition] PCK2 EP300 [activation] AURKB CDK1 [activation] RGS11 CDC37 [activation;inhibition] MAPK1 HMMR [activation] ITGAV PPAP2B [activation] RUNX1 EFNA2 [activation] TGM3 ZBTB1 [activation] MAP2K4 ITCH [activation] PRMT1 IGSF21 [activation] ANXA6 RASA1 [activation] SRPK1 GABARAPL1 [activation] 页 250 共 454


ABI1 TYSND1 TXLNA CDC25C SCTR CFHR3 MDH1 RASL10B NEDD1 CEP120 ITGB1 PRMT1 TP53 HRG EPHA2 STAT5A ELN RXFP3 IRF7 DIXDC1 PSEN1 SMAD3 TAB1 PIAS4 CSNK1E MYC TPX2 VCAM1 C3 MYC CD3G HLA-B HNF1B ITGA4 RASGRF1 AURKA KLC2 CAND1 ERH PRKG2 GNB1 GRB2 BMPR1A ABL1 MAST3 TSHR TLR1 JUP TRAF3 PLCB3 NCK1 NCK1 WDR5 MAP3K3 HIF1A LIFR DYSF ANP32B IKBKB PAXIP1 CASP8 SHC1 A2M ZMYM4 VCAM1 RNF8 MACF1 YAP1 AR ARRB1 FANCB BRAF DZIP3 EXOC6 SRPK2 PIK3C3

2016/4/8 19:14

MINK1 [activation] SCP2 [activation] TBK1 [activation] CHEK2 [activation] PRKCA [activation] C3 [activation] ATG5 [activation] FGFR2 [activation] ACTB [activation] STAT3 [activation] RANBP9 [activation] MLST8 [activation] GRB2 [activation] SPRY1 [inhibition] GATAD1 [activation] UGT2B4 [activation] ELANE [activation] APP [activation] IQSEC1 [activation] MAP3K4 [activation] CASP3 [activation] SRC [activation] HSPA4L [inhibition] NR4A2 [inhibition] ADAM22 [activation] NPC1L1 [activation] AURKB [activation] HSPE1 [activation] TGM2 [activation] TIAM1 [activation] CD3D [activation] RAB1B [activation] HIST1H3A [activation] TTLL12 [activation] MDM2 [activation] IKBKB [activation] PIK3R3 [activation] SRPK1 [activation] SETDB1 [activation] HSP90AB1 [activation] GNAI2 [activation] CD164 [activation] GDF9 [activation] ROS1 [activation] HNRNPA0 [activation] GNAS [activation] TRAP1 [activation] CCDC130 [activation] NMRAL1 [activation] PARD6A [activation] NEK8 [activation] DAG1 [activation] MYB [activation] MAP3K7 [activation] FHL2 [activation] IL31RA [activation] ANXA2 [activation] VCAM1 [activation] FAF1 [activation] ANAPC7 [activation] EDA2R [activation] MAPK1 [activation] RAP1B [inhibition] HIST3H3 [activation] CLUH [activation] MDM2 [activation] CCDC8 [activation] ENO1 [inhibition] CCNE1 [activation] PTGER2 [activation] FANCA [activation] HSPA8 [activation] UBE2E2 [activation] PHLDA3 [activation] CAND1 [activation] CALM1 [activation] 页 251 共 454


2016/4/8 19:14

STAT3 HNF1A [activation] LYN RDX [activation] ABI2 PRR16 [activation] CHUK TANK [activation] BAG3 GRB2 [activation] PPP2R5D YWHAB [activation] SRC SPTAN1 [activation] STAT3 CAPN1 [activation] BAAT RB1 [activation] MAPK1 PARP1 [activation] BCL2L11 FEM1C [activation] HRNR MDM2 [activation] HIST1H3A TAF1B [activation] NCOA2 YWHAH [activation] SLC9A3R1 FZD4 [activation] PALB2 CST6 [activation] RASA1 KHDRBS1 [activation] CD81 CSNK2B [activation] IGHG1 TNFSF10 [activation] PTEN AMHR2 [activation] EIF2AK2 TYK2 [activation] FOXP4 FOXP2 [activation] PITX2 PROP1 [activation] TNK1 DDX5 [activation] SNW1 NOTCH3 [activation] F2RL2 ECT2 [activation] E2F3 WNK1 [activation] PRKCZ CFL1 [activation] DDX5 CRK [activation] PRKDC CENPA [activation] YAE1D1 GABARAP [activation] FAAP24 EME2 [activation] SRPK1 FBXO15 [activation] ID1 CAV1 [activation] DDX43 APP [activation] CSNK2A1 PAK1 [activation] IRAK2 TIRAP [activation] GNB5 PSD [activation] PTEN C9orf156 [activation;inhibition] PIK3CB AGTR2 [activation] IKBKB MAVS [activation] IL12B IL12A [activation] PIK3R1 ASAP1 [activation] NAMPT DDA1 [activation] MAP3K10 CNKSR1 [activation] RHOB PHGDH [activation] ENG TGFBR2 [inhibition] TRIM59 TP53 [activation] DOK1 ITGB1 [activation] PTBP3 APC [activation] MYL6 GRB2 [activation] LATS1 TRAF1 [inhibition] RANBP10 PRKCD [activation] PTCH1 ADRBK1 [activation] ETS1 PHF14 [activation] MSL1 RAN [activation] STK11 ADIPOR1 [activation] NUDCD3 GNAZ [activation;inhibition] PTPN6 PRKCA [activation;inhibition] EVL APBB1IP [activation] MAP2K5 GRB2 [activation] PPM1H YWHAB [activation] MYC NRXN3 [activation] SRC EPS8 [activation] PYHIN1 RAD50 [activation] NR4A1 GADD45GIP1 [inhibition] EIF2S2 EIF4G2 [activation] PEBP4 MAP2K1 [activation] MAPK1 PPP1CC [inhibition] MYC CYC1 [activation] PAX8 SERINC1 [activation] GOLGA8F ATF4 [activation] YES1 AR [activation] TIMP1 MMP3 [activation] NR3C1 HSPA1A [activation] PPP2R2D DAPK1 [activation] 页 252 共 454


2016/4/8 19:14

ACTB ASB12 [activation] TNFRSF14 C2orf47 [activation] MACF1 ACTA1 [activation] KIFC3 ATF2 [activation] ATF2 PRDX3 [activation] ARHGEF7 NCK1 [activation] PTPRJ EPOR [activation] CDC27 CASP3 [activation] RAP2B CAMK2B [activation] VCAM1 YARS [activation] FYB ENAH [activation] SMARCA4 NR1H2 [activation] PAX7 FYN [activation] CDK11B CCND3 [inhibition] NR1H3 TMEM161A [activation] STK3 WWTR1 [activation] TNF LIN54 [activation] ENO1 RIPK2 [activation] BFAR CASP8 [inhibition] RNF32 EXOC6 [activation] TP53BP1 MYL12A [activation] PARD3B SMAD1 [activation] PRKDC YY1 [activation] CALD1 OBSL1 [activation;inhibition] GRN CCDC33 [activation] GSK3B CDK5 [activation] IGF1R DOK5 [activation] RNASE1 RELA [activation] POLR2C STC2 [activation] APP NR1D1 [inhibition] SUMO3 RAN [activation] FGR WAS [activation] FTSJ1 EIF1B [activation] ALDH9A1 HLA-B [activation] HNRNPA1 CARF [activation] PAK2 HTT [activation] STX17 EGFR [activation] LYN CDKN1B [activation;inhibition] KAT2B HMGN2 [activation] PSTPIP1 PTPN1 [inhibition] DNM1 SNAP25 [activation] YWHAZ CACNA1S [activation] LATS1 PTPN14 [inhibition] LAT FCGR1A [activation] ESR1 SP1 [activation] YWHAZ MAGEB2 [activation] VAT1 TP53 [activation] HES1 PRKCA [activation] NXF1 AGGF1 [activation] SKP2 CCNA2 [activation] S100A2 AREG [activation] C5orf42 PAK1 [activation] RASA1 RAB5A [activation] CXCR5 GNAO1 [activation] EGFR NRG1 [activation] RPA2 SMARCA5 [activation] CDK5 CCNE1 [activation] TGFBR3 TGFBR2 [inhibition] NMT2 PRKCZ [activation] CDC23 KCTD6 [activation] EGFR EIF2B3 [activation] APLP1 SNCA [activation] PLD2 STXBP1 [activation] PADI4 TP53 [activation] CCDC8 SERPINB12 [inhibition] THOP1 CALM1 [activation] GNB1 AVPR2 [activation] IQGAP1 SUMO3 [inhibition] ACTG1 SUMO1 [activation] GNG12 CAPN1 [activation] H2AFX RNF8 [activation] MARK4 PRKCI [activation] LCP1 CNN3 [activation] MRE11A SNW1 [activation] CDK1 VCAM1 [activation] NRP1 PLXNA2 [activation] 页 253 共 454


2016/4/8 19:14

RFC2 RPA1 [activation] IFNAR1 CRKL [activation] PRKCA NRGN [activation] PKIB E2F3 [activation;inhibition] TP53 PPP2R5C [activation] EIF4A3 PFKFB3 [activation] BCL2L1 BMF [activation] EGFR NCAPH [activation] APP SETD3 [activation] DNAJA2 RB1 [inhibition] SMAD2 IRF7 [activation] SPN ICAM1 [activation] CRK FYN [activation] FADS1 DHCR7 [activation] IGHA1 STK4 [activation] HSPA4 RELA [activation] SYVN1 SHH [inhibition] RASSF9 HSPB1 [activation] F2R GNAT1 [activation] CCR10 CCR7 [activation] CAMK4 HSP90AA1 [activation] ESRRG NR0B1 [activation] TBC1D15 VCAM1 [activation] PRKCA GABRR2 [activation] CD247 CD244 [activation] DDIT3 F2 [activation] CRK RPP38 [activation] MAVS TSPAN6 [activation] LRRK2 GSK3B [activation] BUB1B DAXX [inhibition] HDAC7 FOXP3 [activation] XIRP2 DYSF [activation] ITPKA PRKCA [activation] ESR1 GADD45B [activation] COL1A1 MMP9 [activation;inhibition] SPP1 EPAS1 [activation] FYN KCNA5 [activation] HLA-B COPS3 [activation] PRKACA GABRB3 [activation] AKT1 IRAK1 [activation;inhibition] CSN1S1 TTBK1 [activation] USP1 ANAPC1 [activation] CRK DAB1 [activation] MYC MAP3K5 [activation] RMDN3 WNK1 [activation] HNRNPC FAS [activation] EGFR MAP2K4 [activation] ARPC4 GRB2 [activation] STAT3 NXF1 [activation] LEF1 RB1 [inhibition] KRAS MOCS2 [activation] GNB2 ATXN10 [activation] GAD1 GRB2 [activation] BMPR1B RASD2 [activation] APLP1 PRNP [activation] GSC SMAD1 [activation] APP GIMAP5 [activation] MAPT PKN1 [activation] PTPN11 EPHA2 [activation] MYO6 TP53 [activation] MAFF NFE2L2 [activation] CAMK1 CDKN1B [inhibition] SRPK3 NCL [activation] ARHGAP21 PTK2B [activation] CASP3 BIRC6 [activation] NLGN1 DLG3 [activation] GADD45A PTPRK [inhibition] LZTR1 STAT1 [activation] MAPKAPK5 TAB1 [activation] GADD45A FTL [activation] WASF2 ABI2 [activation] HDAC3 HIF1A [activation] TIMM50 RELA [activation] CD4 DDX5 [activation] CDC42 IQGAP2 [activation;inhibition] MEIS1 HOXA11 [activation] 页 254 共 454


2016/4/8 19:14

CDC5L NUDC [activation] NR3C1 IFNGR2 [activation] PPP2R1A HDAC4 [activation] GLI1 SMAD4 [inhibition] SCAMP3 EGFR [activation] RAPGEF1 SHC1 [activation] CEBPB FOXO1 [activation] CEP76 PLCB1 [activation] PARD3 PARD6A [activation] FANCL FANCF [activation] ADORA1 ATXN1L [activation;inhibition] PLA2G10 PLA2R1 [activation] ACTA1 MAPK14 [activation] BCCIP CTNNB1 [activation] ATG5 DDX58 [activation] ACAP1 VAMP3 [activation] CDH2 PTPN6 [activation] SETD3 RAD21 [activation] SMAD1 KAT2A [activation] ICT1 ACOT9 [activation] CASP7 CFLAR [inhibition] MAP3K7 CNTN2 [activation] JAG2 MIB2 [activation] GADD45A IGSF21 [activation] MYC KLF10 [activation] DHX57 GABARAP [activation] APC MCM5 [activation] SRPK1 BARD1 [activation] GRB2 MYO1B [activation] GNAI1 GNB1 [activation] HSP90AA1 STAT2 [activation] ARPC2 ARPC1B [activation] PLCG1 CD28 [activation] IL6R STAT3 [activation] RPS6KA3 HSP90AB1 [activation] ITSN2 TRIO [activation] CD247 RGAG1 [activation] SIRT2 CDC20 [activation] HSP90AA1 CAMKK1 [activation] PRPF6 AR [activation] CSF2 ILF2 [activation] KMT2A CTNNB1 [activation] CDC42 RAP1GDS1 [activation;inhibition] MAVS EIF2AK2 [activation] STX5 SNAP25 [activation] DOCK1 RAC1 [activation] IL7 APP [activation] ANKRD52 NXF1 [activation] AR MAPK1 [activation] NBN SIRT1 [activation] PPP6C AURKB [activation] XPO1 E2F4 [activation] PLK1 NEK9 [activation] FLNB HSPB1 [activation] ABL1 CNTFR [activation] NUDC WDR31 [activation] SNW1 NUP153 [activation] JKAMP PTGDR2 [activation] BAG6 INSIG2 [activation] CDK5R1 KRT40 [activation] SGTA NME3 [activation] APP CDK4 [inhibition] GNB1 GNA12 [activation] NOTCH2NL PVRL2 [activation] ETS1 MAF [activation] MCM4 CCNA1 [activation] IRF8 CDK4 [inhibition] CDC37 GLMN [activation] PPARG RXRA [inhibition] ANXA1 PRKCI [activation] CAD RICTOR [activation;inhibition] SERPINI2 SGTB [inhibition] HSP90AB1 CSF1R [activation] RAN ITGA4 [activation] RIPK1 KHDRBS1 [activation] TDGF1 FARSA [activation] 页 255 共 454


2016/4/8 19:14

MAP3K8 HSPA8 [inhibition] PPP1R12A FYN [activation] PRNP CSN3 [activation] SNAI1 AJUBA [inhibition] STK16 KCTD14 [activation] UBE2E2 ZNRF1 [activation] APLP2 AKT1 [inhibition] FBXW11 TNF [activation] PPP1CA ATM [activation] MFAP2 ELN [activation] TBK1 TLR9 [activation] CRK ARHGAP17 [activation] BAK1 BCL2L11 [activation] TWF2 FOXJ1 [activation] COL4A3BP PARP2 [activation] ERBB3 EGR1 [activation] GIT2 YWHAG [activation] HSPA8 TRAF6 [activation] HSP90AB1 RPS6KL1 [activation] GABARAPL2 AGTRAP [activation] MAVS CYLD [inhibition] DTX3 UBE2H [activation] UBE2N TRAF2 [activation] GRB2 DUSP15 [activation] CD59 GRB2 [activation] PUM1 CCDC8 [inhibition] RAD51B RAD51D [activation] RPS19BP1 TP53 [activation] EGFR USP9X [activation] BTK PLCG1 [activation] STK4 MCM3 [activation] CD79A PTPRC [activation] NXF1 EIF2A [activation] EZR TNFRSF10B [activation] EZH2 RASA1 [activation] WAS CDC42 [activation] MOS BMPR2 [activation] PIK3CA DNAJB6 [activation] ATF2 UTF1 [activation] PTN TBRG4 [activation] PDGFRB CBL [activation] PROP1 NCDN [activation] APC STRN [inhibition] IFIT2 DNAJA2 [inhibition] TFDP2 LIN37 [inhibition] TOPBP1 BMPR2 [activation] SLC9A1 MAPK1 [activation] ESR1 HSP90AB1 [activation] PPARA SIRT1 [activation] PIAS2 AKT1 [activation] CHN1 HEMK1 [activation] SNX17 LRP8 [activation] PRKDC YWHAZ [activation] HSPA5 PRKAA1 [inhibition] HES1 FANCG [activation] MPP1 RPS6KA1 [activation] YWHAH EIF4E2 [inhibition] GOLGA2 CDK2 [activation] CRK KRT12 [activation] RAB5A PTGIR [activation] KSR2 FKBP6 [activation] SRPK1 P2RX6 [activation] GHR STAT3 [activation] ZHX1 TERF1 [activation] KIAA1551 EXOC1 [activation] KIAA0196 WASH1 [activation] ZNF106 NXF1 [activation] SNW1 DNM1L [activation] TOLLIP RAC1 [activation] STK24 PDCD10 [activation] BLZF1 FHL2 [inhibition] ARAF IRF7 [activation] ADRA2A YWHAZ [activation] TRAF2 SRSF1 [activation] TNS1 AR [activation] LIN52 RBL2 [activation;inhibition] 页 256 共 454


2016/4/8 19:14

DAB1 MYO6 [activation] ITPR1 VDAC1 [inhibition] PLEC GRB2 [activation] SKIL RNF165 [activation] SFN ARHGAP11A [activation] IL2RG IL7R [inhibition] MAPK7 HSP90AB1 [activation] HSPB1 PTBP3 [activation] RABEPK PIKFYVE [activation] VEGFA VEGFB [activation] BARD1 SRSF4 [activation] VAPB STX1B [activation] AURKA HSPA2 [activation] RPL35A ICAM1 [activation] SRPK2 NSG1 [activation] PAK3 PXN [activation] CBL VAV2 [activation] TRAF6 TRMT112 [activation] ITGA2 FHL2 [activation] IQGAP3 LGR4 [inhibition] STAT6 EP300 [activation] GABARAPL2 ANXA2 [activation] MMP2 HSP90AA1 [activation] ARNTL KAT2B [activation] ADI1 SRPK1 [activation] SMARCB1 SMARCA4 [activation] TGM1 RARRES3 [activation] NOD1 MAGED1 [activation] ZMIZ2 TP53 [activation] PRX FYN [activation] KAT2A ESRRA [activation] SMAD4 RAB25 [activation] PRKCZ FEZ2 [activation] HNRNPA2B1 SHC1 [activation] GNAT3 SNTA1 [activation] LRRK2 MBP [activation] DIABLO BIRC8 [activation] SYT4 STX4 [activation] DLAT ESR2 [activation] WNK2 ABL1 [activation] STK32C HSP90AB1 [activation] GPR158 PITX2 [activation] BCL2L1 BCL2L12 [activation] TFRC RAB5B [activation] PDGFRB EIF2AK2 [activation] SIRT1 FHL2 [activation] PYY NPY2R [activation] ERBB2 SUPT6H [activation] PIK3R1 VAV3 [activation] KMT2B ANXA1 [activation] RANBP2 TAF1 [activation] VAPA APP [activation] HSPA1A HSPA8 [inhibition] GORASP1 CASP7 [activation] ZAP70 HSPA4 [activation] HDAC2 NFE2L2 [activation] SPTAN1 SHC1 [activation] CFLAR CDC37 [inhibition] BCL10 CASP8 [activation] MYO1B DAPK1 [activation] CHEK2 MSH2 [activation] HMGB1 ERF [inhibition] TNFSF11 FAM213B [activation] TGFB1 ERBB2 [activation] ACTG1 CFL2 [activation] PHKG2 BZW2 [activation] HSPA4 NOX5 [activation] PLOD2 ATG5 [activation] PBK MBP [activation] NOTCH1 EIF3F [activation] PRKCB SPTAN1 [activation] TRAF2 NMUR2 [activation] MPO RAD21 [activation] ARAP1 TP53BP1 [activation] CACNA1A LAMB1 [activation] STX4 CCDC8 [activation] 页 257 共 454


2016/4/8 19:14

PPP1CC C11orf74 [inhibition] TNFRSF10B RIPK1 [activation] TAB1 DBN1 [inhibition] GSK3B PPP1CA [activation;inhibition] PYCARD CASP1 [inhibition] SHC1 S100A7 [activation] MDC1 BARD1 [activation] ACVR1B SMAD6 [inhibition] ADORA1 GNAZ [activation;inhibition] IL1RAP STAT3 [activation] PTK2B GSN [activation] NUMB GLI1 [inhibition] PLS3 FTSJ1 [activation] CDKN2A MMRN1 [activation;inhibition] TBC1D17 RAB5A [activation] LRRK1 GAB2 [activation] RPA3 RPA4 [activation] ATP7A CLU [activation] LRRC41 NXF1 [activation] SMARCA1 PARP1 [activation] SMAD4 KLF5 [activation] ADRB2 VAPA [activation] TFDP1 CDC20 [inhibition] MVP SKIL [activation] RBL1 AOX1 [activation] XPO1 CCND1 [activation] METTL17 MDC1 [activation] RPA1 CDC5L [activation] NCK1 RAPGEF1 [activation] RPS6KA2 PRKCE [activation] SHARPIN IL1A [activation] PPP1R16A TXNRD1 [activation] PIAS1 PPP1CA [inhibition] DAB2 DVL2 [activation] H2AFZ MYC [activation] GRB2 BCL2A1 [activation] LARP1 BARD1 [activation] ABI3BP FZD5 [activation] MEF2D CASP7 [activation] ATF2 TXNDC5 [activation] PAFAH1B1 SUMO1 [activation] RASD2 SMAD1 [activation] PRKAA1 AES [inhibition] UBE2I TRAF6 [activation] MDM2 MS4A1 [activation] EGFR ATP1A1 [activation] POLD1 LRRK2 [activation] TRAF6 ACTR3 [activation] APEX1 PAK2 [activation] NEDD8 SMC2 [activation] PCNA RPA1 [activation] LRRK2 CCDC43 [activation] F2RL1 CBL [activation] CNOT11 NLK [inhibition] SPR CAMK2G [activation] ANXA1 DLG3 [activation] PRTN3 SERPINB1 [inhibition] GIGYF1 YWHAB [activation] HRAS MUTYH [activation] C5AR1 ARRB1 [activation] CHN1 CDK5R2 [activation] SMAD3 CSNK1D [activation] CBL CORO1C [activation;inhibition] CDK1 PITPNM1 [activation] MME EDN1 [activation] PLK3 MAP2K1 [activation] RAP1A TRAF6 [activation] LEF1 BAX [inhibition] BIRC5 CASP9 [activation] CBLB VAV1 [activation] ANGPTL3 ITGAV [activation] BARD1 ERCC6L [activation] ANXA1 APBB1 [activation] RAF1 ADCY6 [activation] NFYC GLTSCR1 [activation] SHB KDR [activation] 页 258 共 454


2016/4/8 19:14

HSPB1 ARRDC5 [activation] PPARA FABP1 [activation] TGFBR1 SOCS6 [inhibition] TTLL6 MAPT [activation] HIST1H4A RAPGEF2 [activation] CAV1 CD40 [activation] TRIB3 ATF5 [activation] ACSF2 AGTRAP [activation] MPP1 RPS6KA6 [activation] MDM2 PIM2 [activation] RHNO1 HUS1 [activation] JUN ETV4 [activation] HBZ VCAM1 [activation] FCGR2A LAT [activation] TP73 CCNB1 [activation;inhibition] NAB1 NXF1 [activation] HSPB1 GDI2 [activation] MCM4 MCM8 [activation] TFRC CAV1 [activation] HDAC3 RUNX1 [activation] TNFRSF10D MARS [activation] TRAF2 C5orf55 [activation] HIST1H3A EGLN1 [activation] HSP90AA1 STAT3 [activation] MAPK14 UGT2B10 [activation] GRIP1 GRIA2 [activation] CDC5L SMC4 [activation] YAP1 WBP2 [inhibition] EP300 ARNT [activation] MAPK10 RDX [activation] GPRASP2 RAF1 [activation] SORT1 CDK2 [activation] EEF2 MAPK14 [activation;inhibition] ZAP70 LAX1 [activation] PTPN14 YAP1 [activation] JUN GNB2L1 [activation] HDAC4 RFXANK [activation] RB1 SERPINB2 [inhibition] SPI1 SKI [inhibition] PCDHA4 IGSF21 [activation] MAD2L1 OXSR1 [inhibition] HIST3H3 RBP5 [activation] PTPRJ BAAT [activation] APP DNM2 [activation] SCYL2 ARRB2 [activation] POLE2 MAPRE1 [activation] NCOA1 TBP [activation] UBC MAP2K1 [activation] CARD11 PDPK1 [activation] FOXO1 IRF3 [activation] ITGB1 CSF2RB [activation] RPA1 PRPF6 [activation] ARRB1 SREBF2 [activation] RAP2B RALGDS [activation] PIAS1 GATA4 [activation] TLR3 MAP2K6 [activation] AKT3 CASP3 [activation] DIRAS3 CHEK2 [activation] MST1 RASSF1 [inhibition] LRRK2 RBBP8 [activation] H2AFX KAT2A [activation] PRKACA ADD2 [activation] RAN XPO5 [activation] NXT1 PAXIP1 [activation] HMGN1 RPS6KA4 [activation] VCAM1 DNM2 [activation] CAPN7 IST1 [activation] EGFR CD2AP [activation] CUL1 IKBKB [activation] PPP2CA CSNK1A1 [inhibition] SKIL CDC27 [activation] PUM1 ITGA4 [activation] EIF4A2 SPIN3 [activation] CRELD1 GDF9 [activation] VAV1 MAP2K1 [activation] NCK1 FCGR2B [activation] 页 259 共 454


2016/4/8 19:14

IKBKG GCN1L1 [activation] ARPC4 ACTR3 [activation] IGF1R RASA1 [activation] CACNA2D2 IGHA1 [activation] CNR1 GNA15 [activation] HMOX2 SHC1 [activation] PPP2R5E BHLHE40 [activation] CAMK1D CAMKK1 [activation] BCL2L11 TCEB2 [activation] CDH1 CDH3 [activation] UGDH SIRT3 [activation] CSNK1G1 IKZF1 [activation] YWHAG CRK [activation] FYN CNTFR [activation] DENND3 YAP1 [inhibition] PIK3R4 NXF1 [activation] ITIH4 GRB2 [activation] NOTCH1 PPP2CA [activation] UBE3D CCNB1 [inhibition] SETD8 EZH2 [activation] IKBKB NLRX1 [activation] LRRK2 MAP2K3 [activation] ZDHHC17 SREBF2 [activation] PDX1 PASK [activation] ZBTB3 GATA4 [activation] MAX MAD1L1 [inhibition] APPL1 C1QTNF9 [activation] LRP1 GULP1 [activation] VWF MAP3K3 [activation] EIF4A2 SSX2IP [activation] PYCARD CHUK [inhibition] TSC2 YWHAZ [activation;inhibition] LINC00312 ESR1 [activation] TRADD ACTG1 [activation] CD40LG IGHG1 [activation] PROCA1 CCNA1 [activation;inhibition] PTN DFNA5 [activation] RPL23 TP53 [activation] TNFSF11 EEF1A1 [activation] THBS1 FGF2 [activation] FGA IGHA1 [activation] HIST1H2BD ITGA4 [activation] ICT1 PGAM5 [activation] PSEN1 DAG1 [activation] DGKI RASGRP3 [activation] CCR10 CCL2 [activation] UBE2E2 RNF8 [activation] PARP1 PRKAA1 [inhibition] FAM53C YWHAH [activation] RBBP5 MYB [activation] APP FKBPL [activation] KPNA1 EGFR [activation] SUV39H1 SMAD5 [activation] PPP2R1B STAT3 [activation] SETD1A MYB [activation] PDHB MDM2 [activation] RAB10 DOK2 [activation] CDC7 CDK4 [activation] MAPK1 VDR [activation] STIM1 ATP2B4 [activation] SSX2IP CXCL6 [activation] EPHB6 EPHB4 [activation] BCL6 LIMS3 [activation] MLH1 PTP4A2 [activation] DRD2 GNAZ [activation] E2F3 ENOX2 [activation] HNF1B CREBBP [activation] SEC23B SRPK2 [activation] NFKB1 GABARAPL2 [activation] AMBP PIK3R3 [activation] FKBP1A GLMN [activation] CDKN1B SRC [activation;inhibition] GLRX3 GRN [activation] PHC2 CRKL [activation] FZR1 DNAJA1 [inhibition] DCTN1 MAP2K3 [activation] 页 260 共 454


2016/4/8 19:14

CP GAST [activation] LRRK2 PTCD3 [activation] KCNQ1 PPP1CA [activation] ILK ZNF568 [activation] PCSK4 IGF2 [activation] STAP2 PTK2 [activation] HMGN1 ERCC6 [activation] NLRP1 CASP9 [inhibition] POLM UBE2H [activation] EIF2B5 GSK3A [activation] FCGR2B CRK [activation] CAMKK2 SMC3 [activation] CD2AP GRB2 [activation] MYC BUB1 [activation] TRAF6 NLRX1 [activation] GNAI2 CXCR1 [activation] MAP4K5 CRKL [activation] MAPKAPK3 RAB2A [activation] CALM1 IKBKB [activation] JUND FOSB [activation] APP C14orf93 [activation] LRRK2 RAB11FIP2 [activation] PPARGC1A ESR1 [activation] PLCG1 TEC [activation] MDM2 TFRC [activation] LAMTOR1 MDM2 [activation] EIF4G2 EIF4A2 [activation] IGF1R ITGB1 [activation] PRPSAP1 NUAK1 [activation] TUBAL3 SHC1 [activation] DNAJA3 NFKB1 [inhibition] BARD1 SLFN11 [activation] SIRT2 RIPK1 [activation] PPARG CDK5 [activation] GULP1 SMC2 [activation] CD59 SRC [activation] RTF1 PTPN11 [activation] SMAD3 ARHGEF7 [activation] PRIM2 RPA1 [activation] NOTCH1 ROCK1 [activation] A2M CFTR [inhibition] PPP2R5E DOCK9 [activation] OPCML PRNP [activation] GADD45B GADD45G [activation] FLI1 PRKCD [activation] C11orf63 SRPK1 [activation] TCL1A ATM [activation] FYN HSP90AA1 [activation] NXF1 CEP250 [activation] RMND5B SMAD4 [activation;inhibition] SRPK2 APEX1 [activation] EGFR SH2D3A [activation] CASP8 ILK [activation] SFN ANPEP [activation] NPHS1 SRC [activation] ANXA8 ACD [activation] PAXIP1 NOL7 [activation] TFPI ELANE [inhibition] CYTH3 GRASP [activation] MIPEP MYC [activation] PTPRC PAEP [activation] HN1L RASA4 [activation] AKT1 HSPA9 [activation] PTK2B GP6 [activation] GABARAPL2 AAK1 [activation] CTNNBIP1 JUP [inhibition] SHC1 EPS8 [activation] ATG5 ECHS1 [activation] NOS2 RAC2 [activation] TRAF6 MAT2A [activation] PRKCZ MAP2K1 [activation] RARA RXRA [inhibition] SYK PXN [activation] RAP1B RPTOR [activation] NRAS RASA1 [activation] MCM3AP RAC1 [activation] 页 261 共 454


2016/4/8 19:14

TLR2 ATG16L1 [activation] NGFR TSC1 [activation;inhibition] SHC1 DNAJA2 [inhibition] MAPKAPK3 DLC1 [activation] ACTB ANGPTL4 [activation] CTTN ACTR3 [activation] POMC APP [activation] YAP1 SLC9A3R1 [activation] FAM9B RAD51B [activation] EP300 KPNA2 [activation] NRD1 MYC [activation] ITGAV ITGB8 [activation] RAB8A RPA2 [activation] DARC CCL5 [activation] IFNE TUBA1A [activation] TP53INP1 PRKCD [activation] MAPKBP1 MAPK9 [activation] CHRNA7 FYN [activation] KALRN EPHB2 [activation] PIK3R1 EP300 [activation] NOP2 GABARAP [activation] FBXO5 ANAPC4 [activation] GADD45A LMO4 [activation;inhibition] CDKN1A POLD2 [activation] AQP3 PLD2 [activation] LAMC1 LAMB1 [activation] VAMP8 ITGA4 [activation] PLK1 CEP55 [activation;inhibition] DFFA PRKAA2 [activation] IQCE CALM1 [activation] HDAC9 MEF2A [activation] POTEKP ARRB2 [inhibition] ATF2 CEBPB [activation] RPL26 MDM2 [activation] MBL2 CD93 [activation] GRB2 CKS2 [activation] CETP PRKACG [activation] ASF1A CHEK2 [activation] ZFC3H1 BUB1B [inhibition] LZTR1 BMPR1B [activation;inhibition] FBXW11 CTNNB1 [inhibition] APP DECR2 [activation] ITGB3 DAB1 [activation] MIEF1 DNM1L [activation] SUMO3 MEIS1 [activation] NFKBIA DNAJA3 [inhibition] ALPK3 MYC [activation] GNB1 ADRB2 [activation] IKBKE KIF11 [activation] VIM ATF2 [activation] CDK5RAP3 IGKC [activation] TRIM15 FAM151B [activation] SFN SAV1 [activation] PDPN CLEC1B [activation] PTK2 DVL1 [activation] SETD8 TWIST1 [activation] GRB2 ARHGAP9 [activation] PPP2CA PPME1 [activation] ITSN2 PIK3AP1 [activation] RXFP4 KNG1 [activation] ANAPC2 CDC20 [inhibition] CBL TEK [activation] PLK1 ANKRD44 [activation] CRKL NOTCH2 [activation] RHEBL1 TGFBR1 [activation] SPTAN1 CASP7 [activation] TP53 SMAD3 [activation] HSP90AA1 NUDC [activation] APBB1 PRNP [activation] RAB5A ELAVL1 [activation] S100A14 STK11 [activation] ITSN2 WASF2 [activation] NIN PRKACA [activation] SH3BP5L YWHAG [activation] SERPINE2 COL4A4 [inhibition] MYC RIMS2 [activation] 页 262 共 454


2016/4/8 19:14

TGFBR2 APP [activation] GRB2 ACTC1 [activation] HDAC1 IDH2 [activation] TLR3 SYK [activation] CDKN2C DRAP1 [inhibition] FYN CDKL5 [activation] VIPR2 APP [activation] CHRM1 ARRB2 [activation] PFKFB2 PRKACA [activation] CTNNB1 TFAP2A [activation] RPTOR MARK4 [activation;inhibition] RECQL5 POLR2I [activation] PRKCD RANBP9 [activation] TCEANC DAB1 [activation] FASLG PACSIN2 [activation] NMT1 TP53 [activation] EIF4E2 MIPOL1 [inhibition] PIK3CD CD37 [activation] ANXA2 ARF6 [activation] PIK3CG BCR [activation] CCR8 TPST2 [activation] PRKAA1 ULK2 [inhibition] SENP3 EP300 [activation] TENM3 SMAD4 [activation] RCN2 RIPK1 [activation] ATF2 TAGLN2 [activation] HEATR2 PHLDA3 [activation] C20orf195 TRAF2 [activation] OPRD1 OPRK1 [activation] EIF2B1 RD3 [activation] HIF1A SUMO1 [activation] EGFR GAB1 [activation] MAPK14 OBSL1 [activation] ICAM1 EIF3E [activation] SP1 CSNK2A1 [activation] SUFU HDX [activation] CTNNB1 NR5A1 [activation] NFKBIA HNRNPA1 [activation] LRRC7 CDH2 [activation] AKT1 ESR2 [activation] INSR GRB10 [activation] STAT1 RNF11 [activation] BMPR1A SFRP4 [activation] NGEF FAM118B [activation] CACNB4 TBL3 [activation] KSR1 PPP2R5E [activation] TRAF6 EEF1A2 [activation] GNA12 CDH2 [activation] RELA PLK1 [activation] CDK3 CCNE2 [activation] TP53 MSX1 [activation] VAMP4 CCDC155 [activation] BARD1 LUC7L2 [activation] ANKRD44 PPP6C [inhibition] APOH AKT1 [activation] SRC MAP2 [activation] EGFR RAB7A [activation] CHN2 ERBB3 [activation] RUNX1 MYC [activation] NXF1 RPS6 [activation] EIF4G1 CCDC8 [activation] FOXO4 VDR [activation] STK4 PARP1 [activation] PRDX2 PDGFRB [activation] NCL PRKCZ [activation] PPP2R3C IKBKB [activation] MED1 RARA [activation] APC SEC23A [inhibition] HSPA8 PPP1CC [inhibition] PPHLN1 BCL2L1 [activation] E2F1 CREBBP [activation] WNK1 TNRC6A [activation] UBAP2L NLK [inhibition] PRKAA1 SRPK2 [activation] SMARCB1 PPP1R15A [activation] IGFBP6 IGF2 [activation] 页 263 共 454


2016/4/8 19:14

PSEN1 BACE1 [activation] RPA3 RAB2A [activation] TSSK6 APP [activation] CCL28 DDI1 [activation] E2F5 SMAD3 [inhibition] RHOB RHPN2 [activation] C7orf43 AMOTL2 [activation] CD81 CD53 [activation] SPAG9 MAP3K3 [inhibition] TNIK ACTG1 [activation] MYC GCN1L1 [activation] TSSK6 HIST1H3A [activation] MBNL3 SRPK1 [activation] MCAM FYN [activation] DVL2 PARD6A [activation] PAK1 ZNF418 [activation] NOTCH2NL CRCT1 [activation] CSNK1E RAD54B [activation] NFKB1 HDAC4 [activation] PLG SERPINB6 [inhibition] PRR20C NCK2 [activation] PDIK1L HSP90AB1 [activation] UBA5 EIF3A [activation] RAN SPAG8 [activation] TSTD2 DCC [activation] WNK1 OXSR1 [activation] SGTA C1QA [activation] COL1A1 PDGFB [activation] NGB GNAI3 [activation;inhibition] EIF2B1 UBC [activation] RIMS1 RAB10 [activation] GATA6 HHEX [activation] CDK11B CDC37 [activation] CCNH MTA1 [activation] ETV1 EP300 [activation] SPICE1 ESRRA [activation;inhibition] RPS6KA5 APP [activation] FGFR4 WIF1 [activation] CAMK2N2 CAMK2A [activation] ACTA1 RELA [activation] NOTCH1 TRAPPC9 [activation] INADL PARD3 [activation] HLA-A HLA-B [activation] EPB41L5 RAPGEF2 [activation] LXN NUDC [activation] MDK SDC3 [activation] SNAP25 STX3 [activation] TNFRSF1A RAC1 [activation] CARHSP1 STC2 [activation] MRE11A RAD50 [activation] CTR9 PTPN11 [activation] CAV1 HSP90AA1 [activation] MAP2K4 APP [activation] TLR6 TRAP1 [activation] CACNA1A MATK [activation] RAN GADD45G [activation] BCL2L1 FKBP8 [activation] MDC1 ANAPC2 [activation] MEX3C SMC2 [activation] TSTD2 APC [inhibition] RAB1A RICTOR [activation] APC LRP8 [inhibition] KIAA1598 ESRRG [activation] MCM7 CCND1 [activation] BAG1 MAPT [activation] SST SSTR1 [activation] HLA-G KLRD1 [activation] MAP1LC3B SPAG9 [inhibition] IL7 CEBPE [activation] C18orf25 SRPK1 [activation] HSP90AB1 MDM2 [activation] HLA-E KLRD1 [activation] THRB ROBO4 [activation] HSPA8 ITGA4 [activation] SKIL CHPF [activation] KIF11 CDK1 [activation] 页 264 共 454


2016/4/8 19:14

H3F3A ING2 [activation] TRAF6 PRKCZ [activation] MATK AR [activation] GRN OTX1 [activation] SRC ARRB2 [activation] STOML2 ATG5 [activation] ICT1 ME2 [activation] CREBBP FOSB [activation] KCNA5 HSP90AB1 [activation] WHSC1 PSIP1 [activation] MLLT6 CEBPG [activation] HCK SH3KBP1 [activation] NFE2L2 JUN [activation] NIPAL3 EDA [activation] INSR VAV3 [activation] FZR1 MAPK8 [activation] RAB11A FTSJ1 [activation] CD47 PTK2 [activation] KIAA0196 FAM21C [activation] KAT5 TWIST1 [activation] DTX1 EP300 [activation] HABP2 COL4A1 [activation] CAV1 PRNP [activation] PLN SLN [inhibition] TP53 UTP14A [activation] MAGEC2 ATM [activation] CREBBP ING1 [activation] E2F1 NXF1 [activation] PAK1 ESR1 [activation] CHUK SRC [activation] CD79A FCAR [activation] GABARAPL2 PHGDH [activation] PRKDC PGR [activation] MAPK14 PML [activation] SETD6 RELA [activation] C1QA C1R [activation] PRKAA1 PPARG [inhibition] CDKN1A CCNO [activation;inhibition] PKMYT1 MAPK8 [activation] CRMP1 FAS [activation] PTCH1 SHH [inhibition] NRP1 PGF [activation] SRPK2 DRAP1 [activation] NF1 SUMO1 [activation] TRPM1 MYC [activation] DNM1 LRRK2 [activation] STK3 TRAF1 [activation] NOM1 BARD1 [activation] HSP90AB1 WHSC1 [activation] RAB5C VCAM1 [activation] PKN1 CDC25C [activation] SRC EPB41L3 [activation] PLK1 FABP3 [activation] HDGFRP3 LYN [activation] NBN RRM2B [activation] ADAM10 TSPAN33 [activation] UBE2I RAD54L2 [activation] MAPK8 TNFRSF10B [activation] APOA5 LPL [activation] PRKCA AVPR1A [activation] HSP90AB1 FBXO34 [activation] MAPK10 DDX5 [activation] LCK SOCS2 [inhibition] EP300 HIST1H1D [activation] SRPK3 DHX9 [activation] PAK2 TRIM28 [activation] HMGB2 TRAF6 [activation] CD24 FGR [activation] SIX4 KDM6A [activation] PPARG NR0B1 [activation] SH2B3 ERBB2 [activation] PAK2 UBE2V1 [activation] IFNAR2 STAT3 [activation] TCEB1 KMT2A [activation] BRK1 WASF1 [activation] VCAM1 SNAP29 [activation] 页 265 共 454


2016/4/8 19:14

FANCA ERCC4 [activation] S1PR3 GNAQ [activation] SUV39H1 SIRT1 [activation] ARHGAP10 PAK2 [activation] COPA PDGFRB [activation] ADAP1 PRKCE [activation] STIP1 EGFR [activation] NTN4 NEO1 [activation] PPIF ATF2 [activation] NXF1 FAM192A [activation] IFNAR1 JAK1 [activation] RRAS CRK [activation] EPSTI1 NOTCH2 [activation] NUAK2 HSP90AB1 [activation] ARRB1 MAP2K3 [activation] PIN1 FOXP2 [activation] TNFRSF25 TNFSF12 [activation] ANAPC5 CREBBP [activation] SLC9A3R1 CTNNB1 [activation] PDE5A PRKG1 [inhibition] GSN BCAR1 [activation] DVL3 CSNK1E [activation] RAD54B TCEANC [activation] MYC DIMT1 [activation] GNAI1 RIC8A [activation;inhibition] GNB1 PTH1R [activation] SLA FGFR1 [activation] SMAD2 ARL4D [activation] GATAD2B FOXP2 [activation] RPS6KB1 CDK1 [activation] MCM7 VCAM1 [activation] RRAGC LAMTOR5 [activation] GRB2 SHBG [activation] KCMF1 RASSF10 [inhibition] CHGB OGG1 [activation] TJP1 F11R [activation] MAPK1 GORASP2 [activation] GRB2 BPGM [activation] MLLT4 RALGDS [activation] GNG2 RICTOR [activation] NCK1 EHMT2 [activation] TBXA2R AAMP [inhibition] ITGB1 CD151 [activation] MDM2 FOXO3 [activation;inhibition] COL1A1 MAG [activation] ABHD5 PLIN1 [activation] TGFBR3 INHA [activation] GRN ARFGAP1 [activation] KCTD9 STX11 [activation] GRAP LCK [activation] CDX4 PRKAA1 [inhibition] PTBP3 GRIA4 [activation] WHSC1 TIAM1 [activation] FRAT2 NRAS [activation] SERPINB13 ELANE [inhibition] MAPK8 NCOA3 [activation] BCCIP RAD51 [activation] CASP3 AR [activation] CRKL WIPF1 [activation] TXK MET [activation] LRRK2 TRIB2 [activation] ESR1 DSG1 [activation] PNO1 EGFR [activation] RIMBP3 PRKAA1 [inhibition] MPP3 EZR [activation] PRKCD GRM5 [activation] SCARF2 GRB2 [activation] PIK3R1 DLGAP2 [activation] FAS SRC [activation] PRAM1 LCP2 [activation] GRB2 RPL12 [activation] YWHAZ MCM3 [activation] MAPK1 HDAC4 [activation] SH2B3 LCK [activation] BUB1B SKIV2L2 [inhibition] ARMC8 CTNNA1 [activation] 页 266 共 454


2016/4/8 19:14

ANK1 SLC4A3 [activation] EGFR XPOT [activation] RAF1 RBL2 [activation;inhibition] JUN PML [activation] HIST2H2BE AKT1 [activation] JUNB BDNF [activation] FZD7 SDCBP [activation] PLG RELA [activation] EPHA7 EPHA3 [activation] AKT1 ITPR1 [inhibition] ETS1 NR3C1 [activation] EXOC5 ENO2 [activation] ARRB2 C11orf84 [inhibition] CSNK1D PTBP3 [activation] EGFR LONP1 [activation] DRD2 EPB41 [activation] NUP155 ZFYVE9 [activation] TP53 UCHL1 [activation] CDK4 ACTR3B [activation] RUNX1 SMARCB1 [activation] IL2RG PTPRJ [activation] UBTF SMURF1 [activation] IRF7 MAVS [activation] YWHAH GAB2 [activation] RET FRS2 [activation] GADD45B CDK1 [activation] VAV2 GAPVD1 [activation] TAB2 CALM1 [activation] SKIL LRP1 [activation] HSD17B4 GABARAPL1 [activation] PTPN12 PTK2B [activation] MCM8 CDC6 [activation] LRRK1 SHC1 [activation] LPL VLDLR [activation] CBL ACTG2 [activation] BRK1 ABI2 [activation] TNFRSF1B CAV1 [activation] ABL1 JUN [activation] SMURF1 DNAJC7 [inhibition] YES1 HSP90AA1 [activation] GADD45A MTOR [activation;inhibition] SPP1 PDLIM7 [activation] HSF1 PRKDC [activation] PTPRA BCAR1 [activation] CAV1 ITCH [activation] GRB2 DAB2 [activation] POLD1 SRC [activation] AGPS MDM2 [activation] RPA1 UNG [activation] WIPI1 ESR1 [activation] IDE IAPP [activation] EDNRB EDN3 [activation] YWHAG LRCH3 [activation] NPAS2 ARNTL [activation] HSP90AB1 SGK3 [activation] SKP2 FOXO1 [activation] CEBPB MYC [activation] PTEN CDH1 [activation] TTN TCAP [inhibition] BTG1 SKP2 [activation] LCK PRKCA [activation] USP9X RPTOR [activation] RBPJ SND1 [inhibition] MAPK14 ADRB2 [activation] MAP4K1 GRB2 [activation] YWHAZ ANXA2 [activation] EEA1 ZFYVE16 [activation] ANXA5 APP [activation] FKBPL NOD1 [activation] WAS ENAH [activation] CNKSR2 RALA [activation] SH3KBP1 ANAPC7 [activation] DDX51 MCM7 [activation] GSK3B EIF4EBP1 [activation;inhibition] ELK1 PIAS2 [activation] HSPA5 CDH1 [activation] 页 267 共 454


PRKACG ARPC5 CASP8 WDTC1 RANBP9 DDI1 NGFR ADCY1 PLD3 SBF2 TTC21B ARPC2 ESRRA HBE1 CYTH1 PIK3CA SNW1 CD28 MYD88 CCND1 BMPR1B WAS GNB5 LRRK2 CCNA2 NOTCH1 EFNB1 EIF2S1 SNAP25 KCNAB2 SFN VCAM1 EP300 FYB CALM1 HEXA PDGFRB PKM RPA2 GP5 CCNB1 CAV1 GRB2 HSPA1A RAB5A BRCA1 CDK6 SMG6 USP6 YWHAG WDR18 DDR1 BAAT PPM1D MDM2 SOD1 GRB2 MAPRE1 BMPR1B OPRD1 DOK1 RPL7L1 PLCG1 TTC9C RELA BMP10 RAB11B PPM1A RAF1 FKBP3 FOXD3 CACNA1A CDC42 RHEBL1 ARAF FXYD1

2016/4/8 19:14

CDK17 [activation] MAPKAPK2 [activation] EIF2AK2 [inhibition] NUDC [activation] SOS1 [activation] DVL2 [activation] CD80 [activation] ADCY2 [activation] EGFR [activation] FOS [activation] ESR2 [activation] HLA-B [activation] PRKCD [activation;inhibition] VCAM1 [activation] GNAQ [activation] ATR [activation] EIF4G2 [activation] DUSP14 [activation] PRDX1 [activation] TBC1D2 [activation] TRAF6 [activation] GRB2 [activation] NUDC [activation] ARPC2 [activation] TP73 [activation;inhibition] JAG2 [activation] SMURF1 [activation] SUMO3 [activation] PRKACA [activation] KCNA5 [activation] PI4KB [activation] RPS16 [activation] DYRK1A [activation] CBLB [activation] GRK4 [activation] H2AFX [activation] SOCS1 [activation] ATF2 [activation] SDF4 [activation] F2 [activation] SNW1 [activation] PRKCDBP [activation] ERRFI1 [activation] TRIAP1 [inhibition] KDR [activation] RELA [activation] SSBP2 [inhibition] TERT [activation] CDC42 [activation] BCR [activation] ANXA7 [activation] MAPK6 [activation] GOLGA8DP [activation] DIRAS3 [activation] NUCKS1 [activation] RNF19A [inhibition] EFS [activation] EIF1B [activation] RHOD [activation] GNA15 [activation] NCK2 [activation] GABARAP [activation] RYR1 [activation] VCAM1 [activation] NSD1 [activation] BMPR2 [activation] TBC1D14 [activation] PRKCB [activation] BCL2L1 [activation] MDM2 [activation] POU5F1 [activation] LRP1 [activation] MAP3K10 [activation;inhibition] AKT1 [activation] RAF1 [activation] PPP1CA [activation] 页 268 共 454


2016/4/8 19:14

DOK2 CFLAR [inhibition] H1F0 RAD51B [activation] JAK2 ABL1 [activation] IRS1 BCL2 [inhibition] TEC WAS [activation] PPP3CC APP [activation] APOC3 VKORC1 [inhibition] SNX8 GRB2 [activation] GRB2 DBN1 [activation] HSPA1L TAB1 [inhibition] PAXIP1 LYAR [activation] ACAP1 ITGB1 [activation] NOXA1 RHOU [activation] TXNDC5 MDM2 [activation] EIF5B ETS1 [activation] MOS FYN [activation] RELA USP31 [activation] C22orf46 APP [activation] PKNOX1 MEIS1 [activation] CFP MTOR [activation;inhibition] NOV ITGAV [activation] FAM194A HSPB1 [activation] TWIST1 ELSPBP1 [activation] IFIT1B IFIT1 [inhibition] CTNNB1 CTNND2 [inhibition] GABARAPL2 NEK9 [activation] EEF1D ATG7 [activation] TRIM24 ESR2 [activation] PRKCA RALBP1 [activation] ARPC3 SUMO3 [activation] GFAP STAT1 [activation] TFDP1 LIN54 [inhibition] EP300 GRIP1 [activation] CA9 CTNNA1 [activation] CDC25B BTRC [activation] HBE1 HBZ [inhibition] HNRNPA0 ARRB2 [activation] IRAK2 SMURF1 [inhibition] TFF1 RAD51 [activation] HSP90AB1 NEK9 [activation] SMAD2 C9orf156 [activation] VAPA ATF2 [activation] EGFR ZNF259 [activation] VPS45 IGF1R [activation] SH2D2A GAB1 [activation] TRAF6 SYK [activation] ASAP2 PLCG1 [activation] MYCN ZBTB17 [activation] PES1 ARRB2 [activation] CARM1 KAT2B [activation] DENND5A PRKCZ [activation] IRS1 PIK3CB [activation] CAMK4 CABIN1 [inhibition] MMP2 HAPLN1 [inhibition] OPRM1 ZYX [activation] F2RL1 GPRASP1 [activation] SH3BP2 ERBB2 [activation] RANBP2 CDC5L [activation] UBE2B TP53 [activation] HSP90AA1 EGFR [activation] ARF6 RGS10 [activation;inhibition] TERF1 TINAG [activation] FES IRS1 [activation] YWHAH RIMS1 [activation] CCNC GATA1 [activation] IRS4 ERBB2 [activation] CECR5 ICT1 [activation] MDM2 HIPK2 [activation] PRKCA CREM [activation] MLH1 PPP2R2B [activation] DLL1 EPN1 [activation] BCL2L1 BCAP31 [activation] BCAR1 FES [activation] SRPK2 ARPC1B [activation] ARAF BAD [inhibition] RIT2 HRAS [activation] 页 269 共 454


2016/4/8 19:14

ARMC7 ABI3 [activation] ANXA5 SUMO2 [activation] CUL7 RAN [activation] PRKCZ CASP8 [activation] PLG CPB2 [activation] PPIF MDM2 [activation] KCNE4 KCNQ1 [activation] WWTR1 AMOT [activation] GNA15 FKBPL [activation] SYT16 AGTRAP [activation] ABL2 HRAS [activation] DDX39B HNRNPLL [activation] ILK CNNM3 [activation] FOS NCOA1 [activation] KLHL38 NUDC [activation] CTNNB1 NUMB [activation] RASGRF1 CEBPA [activation] ABL1 BMP2K [activation] SHC1 STAT5B [activation] FGFR1 FRS3 [activation] GMPS HLA-B [activation] MYC RFC2 [activation] CA9 ACACA [activation;inhibition] FUBP3 GRB2 [activation] TNFRSF1A RIPK2 [activation] PAK2 PACSIN3 [activation] C3 FN1 [activation;inhibition] NEB MAPK14 [activation] CDK11A PAK1 [activation] HMGB1 AR [activation] CDK4 IFI27 [inhibition] GJB2 CD14 [activation] VCAM1 SMCHD1 [activation] SHC1 PIK3C2B [activation] RARA CREBBP [activation] ANXA2 RPA1 [activation] YES1 PECAM1 [activation] METTL17 ICT1 [activation] DDA1 UBE2E3 [activation] PRKACA ITGA2B [activation] MMP12 ELN [activation] TICAM2 IRAK2 [activation] SHB AR [activation] HSPA6 CDC5L [activation] MAPKAPK3 IGHM [activation] SCFD1 GOSR1 [activation] DYRK1A FAM53C [activation] ESR2 MYO1C [activation] YAP1 YWHAZ [activation] RPA2 HELB [activation] PHACTR2 GRB2 [activation] ARHGAP17 FMNL1 [activation] PTK2B MAPT [activation] RPL7L1 EGR2 [activation] DNM2 SHC1 [activation] PALB2 CCL5 [activation] BTK HSP90AB1 [activation] RAD51 IRS1 [activation] SMC2 GSTK1 [activation] MRPS22 SMURF1 [inhibition] KPNB1 MLH1 [activation] PLCG1 ITK [activation] TTC23L CTAGE5 [activation;inhibition] HSP90AB1 CDK6 [activation] NOD1 CASP2 [activation] EGFR SYK [activation] TGFB1 APP [activation] MCC TFRC [activation] AHCYL1 CDKN2C [inhibition] PRPF40A ARFGEF2 [activation] UNG HSPB1 [activation] WNK1 YWHAZ [activation] E2F3 CTNNA1 [activation] IL1B IL1RAP [activation] EIF2AK2 MAP3K5 [inhibition] SMARCC1 CCNE1 [activation] 页 270 共 454


2016/4/8 19:14

PSMB1 INSIG2 [activation] PPP2CA TP53 [activation] MTIF3 PAXIP1 [activation] CAPZA1 ATG5 [activation] STXBP1 PRKCA [activation] HSPA8 IVNS1ABP [inhibition] MAPK1 MAP2K6 [activation] SNAI1 HIST1H3A [activation;inhibition] BTG1 RARA [activation] ARRB2 PPM1B [inhibition] SPP1 CASP3 [activation] ANXA7 SRI [activation] LINC00312 SRPK1 [activation] TRAF6 PFN2 [activation] PIK3R1 NR5A1 [activation] FYN LAT [activation] RAD21 AZU1 [inhibition] PIK3R1 IL6ST [activation] PAG1 EGFR [activation] TRAF6 RHOC [activation] CCNA2 DYRK1A [activation] PLCG1 RET [activation] NEDD8 EIF2B4 [activation] EHMT1 MDM2 [activation] GOLGA2 MDM2 [activation] GAK AP1M2 [inhibition] BCAR1 CASP3 [activation] DLGAP5 APP [activation] TRAF6 OTUD7A [activation] BTK TLR6 [activation] CCNA1 MCM3 [activation] SRPK3 SNRPC [activation] MMP1 CD44 [activation] ACACA FBXO6 [activation;inhibition] ICT1 MRPL54 [activation] APOL5 PIK3R1 [activation] PIK3CG PTPN11 [activation] TRAF6 MRTO4 [activation] RPA3 BLM [activation] TUBB4A LRRK2 [activation] HSPA6 GABARAP [activation] TFRC ADRB2 [activation] SUPT6H TP53 [activation] SUMO3 AURKB [activation] EPHA7 GNB1 [activation] ADAM10 GRB2 [activation] SKP2 SMAD4 [inhibition] TUBB4A IKBKB [activation] GTPBP3 IGHA1 [activation] ANKRD11 TRAF2 [activation] ZAK MIDN [activation] ILK DHCR7 [activation] ADCK3 ICT1 [activation] TRAF6 MCL1 [activation] BARD1 TOP1 [activation] EFS PTK2B [activation] COL4A5 SERPINE2 [inhibition] POLE2 AGFG1 [activation] ITGB1 YWHAB [activation] KDM1B EHMT2 [activation] RARA RXRG [activation] TERT XPO1 [activation] GNL3 EIF2AK2 [activation] MAPK1 CUEDC2 [activation] RUNX1 ELF4 [activation] EYA1 H2AFX [activation] PIK3R4 KRIT1 [activation] FXYD7 APOE [activation] ARF6 PLS1 [activation] VIPR2 VIP [activation] EPHA2 PIK3R2 [activation] EIF4G2 EIF5 [activation] ARPC4 ITGA4 [activation] PKIA PRKACB [inhibition] CRY1 CBLB [inhibition] RAD21 CTTN [activation] 页 271 共 454


2016/4/8 19:14

RXRA NPAS2 [inhibition] TOP2A RAC1 [activation] GRB2 CRYBB3 [activation] ACTN1 PTPN1 [activation] RPS6KB1 HSP90AA1 [activation] GRAP SHC1 [activation] BMP6 SOSTDC1 [activation] IL25 ESR1 [activation] HGF SRPX2 [activation] VCAM1 MRPL43 [activation] RELA TCAP [inhibition] HIST2H2AC H2AFX [activation] VAMP7 AP3M1 [activation] TERF1 POT1 [activation] SPERT ACTN1 [activation] THBS1 SOX2 [activation] STK3 RASSF4 [activation] PRNP FAM64A [activation] GADD45G EZH2 [activation] RFC1 ATM [activation] TRMT2B ERCC1 [activation] FBLL1 DDX56 [activation] DDX56 DHX37 [activation] CREBBP EGR1 [activation] ACTB MDM2 [activation] GRK5 EIF2S3 [activation] HUWE1 CRKL [activation] CTNNB1 PTPRK [inhibition] NUDC NXF1 [activation] SMARCA4 H2AFX [activation] CSNK2A1 EIF5 [activation] TP53 MAP1B [activation] PTK2 DCC [activation] STIP1 LRRK2 [activation] LIPE PLIN1 [activation] TGFBR1 RASD2 [activation] CD4 SELL [activation] ACVR1 RHOD [activation] E2F1 SETD7 [activation] MAPKAPK3 SUMO3 [activation] PRKCQ MSN [activation] RASL10B AKT1 [activation] ECSIT APOE [activation] YWHAZ LRMP [activation] ENO2 ANXA11 [activation] TMEFF1 PTEN [activation] STK4 CNKSR1 [activation] PTMS CREBBP [activation] F2R GPRASP1 [activation] SMAD3 ETS1 [activation] HNF1A GATA5 [activation] DPP4 GCG [activation] ITGA5 PPAP2B [activation] PPP2CA ID1 [inhibition] MAP3K7 CALM1 [activation] LNX2 PKDREJ [activation] PTPRJ LCK [activation] RHOQ TRIP6 [activation] LRRK2 C5orf45 [activation] GNAI2 IL8 [activation] RARA NPAS2 [activation] CR1 C4B [inhibition] ARHGEF11 ARRB2 [activation] ESR2 RFX6 [activation] TP53 YTHDF1 [activation] MYD88 RAC1 [activation] YWHAH MAST3 [activation] RYR1 MYOM2 [activation] SMARCA5 RPA3 [activation] CUL1 PPP2CA [inhibition] GNAI2 OPRM1 [activation] PIK3R4 YWHAE [activation] YAP1 RAPGEF6 [activation] XIAP HSPA4 [inhibition] CDK5RAP2 MAGEH1 [activation] LAT SH3BP2 [activation] 页 272 共 454


2016/4/8 19:14

ZAK MPP1 [activation] FSCN1 NGFR [activation] CDX4 LMO1 [activation] IGF1 IGSF1 [activation] MDM2 RNF126 [activation] CLUAP1 MYOG [activation] MIF FTSJ1 [activation] TERF1 CAPNS1 [activation] HDAC4 IFRD1 [activation] ACVR1 TTC27 [activation;inhibition] TSC1 HBA1 [inhibition] MYOD1 TWIST1 [activation] SUMO1 ANXA5 [activation] MMP8 TFPI [inhibition] CDK6 ATF6B [inhibition] PALB2 BRCA1 [activation] TP53 FZR1 [activation] SLX1A PLK1 [activation] KLK3 EPOR [activation] DLL1 NOV [activation] PRKDC H3F3A [activation] PIK3C3 CD5 [activation] DVL1 TFDP1 [inhibition] MDM2 ARHGDIA [activation] SHC1 FAM118B [activation] MYC CDK5RAP2 [activation] NRBP1 RIBC2 [activation] OSR1 TGFBR2 [activation] TRAF2 RIPK2 [activation] GRB2 PRR22 [activation] ARRB1 MAPK10 [activation] RAD9A NR3C1 [activation] CLOCK SIRT1 [activation;inhibition] CLSPN RPA1 [activation] A2M HMOX2 [inhibition] TUBB4A MAP3K7 [activation] ANAPC7 CREBBP [activation] TRIM54 PIK3R3 [activation] CRK STAT5B [activation] TAB3 SMAD7 [activation] SETD8 SUMO1 [activation] A2M ELAVL3 [inhibition] BTRC HSF1 [activation] RAC1 ITGA4 [activation] LIFR PLCG1 [activation] SETDB1 PPA1 [activation] HSPA5 INSIG2 [activation] RAC1 LTBP4 [activation] CDK5RAP2 REPS2 [activation] CDKN1A VDR [activation] PIK3CB UBC [activation] GAB1 TEC [activation] ADRBK1 PRKCD [activation] RAP1A BMX [activation] GNAS CALM1 [activation] CDK6 ABI1 [activation] DNAJB5 ASB4 [inhibition] ARHGEF11 PLXNB3 [activation] WDR1 CARD11 [activation] USP3 GNA13 [activation] CSN2 CDC42 [activation] PLCG1 KIT [activation] MCM10 CCND1 [activation] SLC25A4 PPID [inhibition] SRI RYR2 [activation] IL27 EBI3 [activation] HSPA1A HSBP1 [inhibition] MKLN1 MYC [activation] HSP90AA1 MAP3K7 [activation] RIF1 BOC [activation] CD8A LCK [activation] ATG5 IFIH1 [activation] CTGF FGFR2 [activation] PHLDA3 ARMC6 [activation] SMAD2 LRPAP1 [inhibition] RASA1 AFAP1L2 [activation] 页 273 共 454


2016/4/8 19:14

XPO1 NRIP1 [activation] SRSF6 APP [activation] AURKC SRPK1 [activation] HSPA2 UNC45B [activation] CDCA4 KAT2B [activation] IKBKG DAPK1 [activation] EIF2B1 ADRA2C [activation] FTSJ1 XIRP2 [activation] CASK TIAM1 [activation] CUL1 TRAF6 [activation] PIK3CA DGKZ [activation] TULP3 RIOK3 [activation] CASP3 TFAP2A [activation] PPP1R12A MAP3K3 [activation] PPM1G MTNR1B [activation] ARRB1 HSPA7 [activation] CHD4 EP300 [activation] PPP2R5A CHEK2 [activation] BMP3 PRMT6 [activation] BRAF RAF1 [activation] GARS HLA-B [activation] SNAP91 NECAP1 [activation] SPRY4 RAF1 [activation] L1CAM EZR [activation] TP53 KPNB1 [activation] CCL2 PCNA [activation] FGFR3 SLC25A6 [activation] UBE2G2 VAMP8 [activation] SYK HDAC4 [activation] ELMOD2 RHOG [activation] PLCB1 MAPK1 [activation] HRAS TTC1 [activation] ACTB CEP250 [activation] SYN1 PRKACA [activation] EIF4EBP1 MAPK14 [activation] CCND3 MYB [activation] TREX2 ATF4 [activation] BRCA2 FYN [activation] CAMK2A RAD23A [activation] PHC2 MAPK14 [activation] GRB2 EHMT2 [activation] TRAF2 RIBC2 [activation] ABI1 YES1 [activation] PIK3CG PIK3CD [activation] CDH5 CTNND1 [activation] DUSP6 MDFI [activation] TNFRSF11B VWF [activation] CHUK NR2C2 [activation] TGFBR2 KCNK18 [activation] RAB5C SGSM3 [activation] YWHAG TET2 [activation] CAMSAP2 FOS [activation] FGFR1 NRP1 [activation] KPNA2 CDK11A [activation] CALM1 DDX21 [activation] PRKDC CTDP1 [activation] MAPK8 TFCP2 [activation] ARF6 CHRM3 [activation] NSMCE2 TXLNA [activation] GSK3B MGEA5 [activation] NRAS CCDC180 [activation] WASL ABL1 [activation] MYOD1 BHLHE41 [activation] MTOR HSPA4 [activation] CSK ERBB2 [activation] BMPR1B RAB25 [activation] ACTR3 NXF1 [activation] MCM3 NOTCH1 [activation] RAB5C SUN2 [activation] SRC GAB2 [activation] PGM1 PAXIP1 [activation] EGFR BZW1 [activation] LSR MAPKAPK5 [activation] BUB1B HSPB1 [inhibition] APP WARS [activation] C1orf94 CCHCR1 [activation] 页 274 共 454


2016/4/8 19:14

NR1H3 RARA [activation] PHKB CAMK2B [inhibition] EED TNF [activation] CAPZB BCCIP [activation] YWHAQ PRKCZ [activation] KPNB1 ITGA4 [activation] FCGR1A FCGR3A [activation] GSK3A CREM [inhibition] HIST2H2BF CD81 [activation] TDGF1 AP2S1 [activation] PSD3 ARAP1 [activation] NCF1 GNAI1 [activation] APOA5 FAS [inhibition] QRICH1 NLK [inhibition] RRAS2 PIK3R1 [activation] MAGEB1 SRPK2 [activation] YWHAG NOS2 [activation] WHSC1 RRP1 [activation] CNIH4 TNFRSF14 [activation] MAGI2 TGFA [activation] CPNE1 ACTB [activation] CAMK2A KRT18 [activation] IRS4 PTPN11 [activation] IL6 OSM [activation] STAT3 GNB2 [activation] TRAF6 MCM7 [activation] PIK3R1 RAPGEF1 [activation] PALB2 SERPINB5 [activation] NLRP1 BCL2L1 [activation] IRF8 IRF2 [activation] SQSTM1 SNCA [activation] PTGIR GNAS [activation] ARHGAP44 CDC42 [activation] RAP1B FAF1 [activation] PRPF6 ESR1 [activation] E2F1 IGF1 [activation] KCNE1 ADRB2 [activation] RAB4B EXOC5 [activation] APP UBL3 [activation] RXRG CAMK2B [activation] HSPA1L EGFR [activation] EIF3F CD81 [activation] TEK GRB14 [activation] PAK1 FRS2 [activation] TRAF6 SAE1 [activation] PPP1R12A FOS [activation] FBXO6 GRN [activation] HSP90AB1 ILK [activation] AUP1 OPRK1 [activation] PTN BCL2L1 [activation] ACAT2 ATG5 [activation] MAP2K2 CCNDBP1 [activation] IRAK1 PELI2 [activation;inhibition] ERC1 APP [activation] PFN1 SRPK1 [activation] IL32 PRTN3 [activation] DDX5 STK4 [activation] AKT2 LRRK2 [activation] INSR RASA1 [activation] PRKCB RGS2 [activation] GRB2 SH2D1A [activation] PGR STAT5A [activation] CACNA1A LTBP3 [inhibition] FOS MAFF [activation] MMS19 EIF2S2 [activation] FGFR1 IGHG1 [activation] TBCD PPP2CA [inhibition] GRB2 AR [activation] GRB2 GSTP1 [activation] BARD1 AURKB [activation] GORASP2 CBLB [inhibition] TRAF6 PDLIM7 [activation] HSPB1 EIF2S1 [activation] LCK FCGR3A [activation] HNF4A MAPK14 [activation] ITGAE CDH1 [activation] 页 275 共 454


2016/4/8 19:14

YWHAZ MDM2 [activation] EP300 CRTC2 [activation] MLH1 PPP2R1A [activation] GABARAPL2 GARS [activation] CD4 CD81 [activation] VAV2 EPHB2 [activation] PRKACA RANBP9 [activation] CMA1 EDN2 [activation] TNIP2 MAP3K8 [activation] HBE1 ITGA4 [activation] DAB2IP TRAF2 [activation] ITGA4 LARS [activation] FYN SPHK2 [activation] RHOB PRAF2 [activation] HNRNPA1 OBSL1 [activation] CDKN1A GADD45A [activation;inhibition] PLEKHA4 PRKAA1 [inhibition] WAS ACTR2 [activation] YWHAZ ARHGEF16 [activation] CTDSP2 POLR2A [activation] BRCA1 RAD51 [activation] ATG5 EEF1B2 [activation] CTNNB1 NFKB1 [activation] VAPA INSIG1 [activation] SH2B2 CBL [activation] SSX2IP CDC42 [activation] WHSC1 ACTB [activation] GRB2 PBXIP1 [activation] SORBS1 FRS2 [activation] TP53 RFC1 [activation] SMC2 HIST2H3A [activation] TP53 FAU [activation] CDC5L NCAPD2 [activation] SHC1 FCGR3A [activation] IQGAP1 PPARGC1A [activation] EGFR LRWD1 [activation] CASP1 PAK1 [activation] C7orf25 NGEF [activation] ACVR1B XIAP [activation] TUBA4A MAPT [activation] CCDC97 SRPK2 [activation] CHD7 SALL3 [activation] HIST1H3A LRRK2 [activation] HIST3H3 JADE2 [activation] CCDC36 FAM124A [activation] TRAF6 NTRK2 [activation] PALLD SRC [activation] CHUK ARRB2 [activation] GSK3B SMYD2 [activation] KAT2B CEP250 [activation] PPP6R3 NOTCH1 [activation] ULK1 GABARAPL1 [inhibition] OSM COL4A3 [activation] PPP3CB PPP1CC [inhibition] ADRB2 PRKCD [activation] MAP3K2 HSP90AA1 [activation] MYC CHD4 [activation] BCL2L1 SIVA1 [activation] RANGAP1 GNAI3 [activation] SH3BP2 VAV2 [activation] TGM2 ATF4 [activation] GATA1 ZNF521 [activation] CDK4 CDC37 [inhibition] FASLG TNFRSF10B [activation] BRD4 AR [activation] ARHGAP9 APP [activation] EP300 CTTN [activation] EGFR PTPRJ [activation] HMGXB3 CDKN1A [activation;inhibition] ACTG1 MAP1A [activation] BHLHE40 MYOD1 [activation] HSP90AB1 PGK1 [activation] INSIG1 HMGCR [activation] WDR1 CFL1 [activation;inhibition] LILRB1 HLA-A [activation] EIF4EBP1 PRKCA [activation] 页 276 共 454


2016/4/8 19:14

SUMO4 PPA1 [activation] CREBBP MEIS1 [activation] FERMT1 SRPK1 [activation] MMP2 A2M [inhibition] FZR1 RB1 [inhibition] STK3 CSNK1E [activation] STAT1 KDM3A [activation] ATG7 SIRT1 [activation] RPS28 CD81 [activation] TOP1MT TP53 [activation] GABARAPL2 YWHAZ [activation] TEC PIP5K1A [activation] CDK5 CDKN1A [activation] ATG3 CFLAR [inhibition] FAM105B DVL2 [activation] MAML1 SMARCA4 [activation] RASA1 BCL10 [activation] EFNB2 GRM5 [activation] ARRB2 ARHGEF6 [activation] BUB3 TNIK [activation] TGFBR3 INHBA [activation] RHOD ADCK5 [activation] CMA1 FYN [activation] BUB1B HDAC4 [inhibition] PXN ADAM10 [activation] MCM3 MYC [activation] MAST1 YWHAH [activation] PXN ITGA4 [activation] HFE TFR2 [activation] MAPK13 APP [activation] STAU1 NXT1 [activation] TIPIN RPA1 [activation] CDC37 SMYD2 [activation] COL6A1 MAG [activation] IL6ST PTPN6 [activation;inhibition] RECQL5 RAD51 [activation] HIF1A PER1 [activation] TGFBRAP1 TGFB2 [activation] MYC IDH3G [activation] PPP2R1A HDAC1 [inhibition] MTIF3 MAPK1 [activation] SMARCA4 FANCA [activation] GGCX F2 [activation] EWSR1 PTK2B [activation] ESYT2 CAMKK2 [activation] HSP90AB1 CAMK2D [activation] SERPINC1 SDC2 [inhibition] EIF4G1 EIF3A [activation] PLK1 HSF1 [activation] PPP1R12A MCM7 [activation] ITGB1 FBXO6 [activation] ANXA5 COL2A1 [activation] PPP5C HTR2A [activation] TP53 ANKRD2 [activation] HSPE1 ITGA4 [activation] PPP1CA CCND3 [inhibition] TP53 HSPA8 [activation] CALML3 RAD21 [activation] PIP4K2A GSTK1 [activation] PIK3R1 CHRNA7 [activation] MEOX2 SPP1 [activation] CRK PNMA2 [activation] NCK1 SOS2 [activation] PIK3R2 APP [activation] NCOA3 NPAS2 [activation] EYA2 GNAI2 [activation] SH2D1A MET [activation] EGFR MOB4 [activation] PITPNM2 PTK2B [activation] EFTUD2 LRRK2 [activation] ERBB2 RANBP2 [activation] SMURF1 IVNS1ABP [inhibition] WASH1 CTTN [activation] RAD21 PPM1D [activation] FHL2 HCK [activation] PRKCZ PRKCQ [activation] 页 277 共 454


2016/4/8 19:14

NCK1 PIK3CD [activation] MME GAST [activation] LCK RAF1 [activation] MYO1B CUL1 [activation] LLPH SRPK3 [activation] MLLT4 VCAM1 [activation] SOS1 SPTAN1 [activation] CRMP1 HMGB1 [activation] RIMS1 FYN [activation] ATRX MRE11A [activation] FAM192A TRAF2 [activation] LAPTM4B PIK3R1 [activation] PTK2 CCNA1 [activation] CXCL2 EPS8 [activation] PIK3CG SEC14L2 [activation] ARF6 SMARCC1 [activation] ANKS4B APP [activation] RAC1 ARL2BP [activation] ISCA1 ICT1 [activation] HNRNPA1 HSPA2 [activation] SKA2 HMOX2 [activation] RELA PRKDC [activation] MCM3 ARF6 [activation] SRY SMAD3 [activation] ATR PA2G4 [activation] CASP9 DCC [activation] NR4A1 SMAD3 [inhibition] DNM2 CTTN [activation] COMMD10 RELA [activation] DVL2 RAC1 [activation] NOTCH1 KIF2A [activation] CREBBP MYB [activation] UBE2W MARCH3 [activation] HDAC1 AR [activation] MAD2L1 CDC20 [inhibition] SGTA GAL [activation] KCNK15 YWHAH [activation] ITSN1 ZAK [activation] LYN PLCG2 [activation] ATG5 EXOC4 [activation] TRAF3 NGFRAP1 [activation] MLC1 CAV1 [activation] PRKACB MAPRE1 [activation] SRSF12 CDK6 [activation] SEC63 PTP4A3 [inhibition] STAP2 STAT3 [activation] RBL1 PPP2CA [inhibition] MYO5B CCDC8 [activation] GOLGA2 RBL1 [inhibition] PLCB2 RAC1 [activation] OGT NXF1 [activation] TRIM2 UBE2E2 [activation] HSP90AB1 ROCK1 [activation] FLT4 EPN1 [activation] KIAA1377 TNFRSF14 [activation] INSR CALM1 [activation] KDM6A SMARCA4 [activation] APC CTNNB1 [inhibition] SREBF1 INSIG2 [activation] PDGFRA ITGAV [activation] STAP2 CBL [activation] L1CAM NRP1 [activation] LRRK2 TCF25 [activation] RPS6KC1 SPHK1 [activation] CDH1 MAPKAPK3 [activation] AKT2 CCL14 [activation] PFN2 ROCK1 [activation] CASP12 UBE2K [inhibition] SRF NFYA [activation] HSF1 CREBBP [activation] HNRNPL SSSCA1 [activation] SRSF5 CALM1 [activation] TCEAL3 ETS1 [activation] PCSK9 ANXA2 [activation] CDC25A RAF1 [activation] APP DAB2 [activation] 页 278 共 454


2016/4/8 19:14

MAPK1 EP300 [activation] SMARCD1 GATA1 [activation] FAS PRAM1 [inhibition] CAMKK2 CAMK1 [activation] SELPLG SNX20 [activation] SNAP29 STX6 [activation] LRRK2 ENKUR [activation] HDHD2 PIP5K1C [activation] ARHGAP12 SRPK1 [activation] MAST2 PTEN [activation] BCL2L11 MEX3D [activation] PECAM1 PIK3R1 [activation] MAGEB10 MYC [activation] NCOA1 NR5A2 [activation] SKP1 CDK4 [inhibition] PTPRC TNK2 [activation] PPP1CA OBSL1 [activation;inhibition] CDKN2C CCDC90B [inhibition] MAPT PIN1 [activation] DNM1L BCL2L1 [activation] EGFR WASF3 [activation] FER CALM1 [activation;inhibition] GABARAPL2 PRPF6 [activation] SRC RASA1 [activation] ICAM4 IGHG1 [activation] ETS1 HMGB1 [activation] FRS3 BMPR2 [activation] TNFRSF1B GCN1L1 [activation] TBP MYC [activation] GSK3A PRKCH [activation;inhibition] CALM1 SMARCB1 [activation] DAB2 SEC23B [activation] TP53 SLC2A12 [activation] HCK PLCG1 [activation] CSF2 HNRNPA1 [activation] GRN EGFR [activation] SETD7 NR2F2 [activation] SOX8 HHEX [activation] GAB2 MET [activation] ANXA1 PABPN1 [activation] BLK CD79B [activation] RIPK2 SMURF1 [inhibition] RPA3 CSNK1A1 [activation] HRAS CTNNA1 [activation] RAD54B RAD51 [activation] CTNNBL1 SRPK2 [activation] EIF2S2 CAND1 [activation] MYBL2 CDKN1C [inhibition] SDC1 SDC3 [activation] MPP3 MDH1 [activation] JUN USP9X [activation] HCK PLAUR [activation] CAMK2A ITGA2B [activation] NXF1 PSKH1 [activation] NCOA1 DDX5 [activation] UTP14A PRKCZ [activation] PRKCZ F11R [activation] TP53 DMTF1 [activation] TP73 CCND1 [activation] TP53 HPCA [activation] XPO1 SMARCB1 [activation] KMT2E ACTB [activation] ACTB PIK3R2 [activation] ARFGAP1 CYTH2 [activation] MDK LRP1 [activation] IQCB1 DPYSL2 [activation] EPOR CSF2RB [activation] RDH13 GADD45G [activation] MAST2 FBXW11 [inhibition] NFE2L2 CHD6 [activation] HSPA1L METTL21A [activation] TSHR GNA11 [activation] CDC42BPG CDC42 [activation] SRPK1 MKNK2 [activation] OSBPL9 VAPB [activation] IGHM VPREB1 [activation] 页 279 共 454


2016/4/8 19:14

INO80E GEM [activation] STK11 SERPINB5 [activation] LEF1 KPNA1 [activation] IL4R PTPN6 [activation;inhibition] GLMN HSPB1 [activation] VCAM1 FLOT1 [activation] NCK2 ABI2 [activation] CAPN1 GAS2 [activation] VCAM1 SMARCA4 [activation] PPP2CB NOTCH1 [activation] IL2 CD53 [activation] FGR HSP90AB1 [activation] MYC SPEG [activation] AURKB HSP90AA1 [activation] CCL7 DARC [activation] TNFRSF1A DAPK1 [activation] CDKN1A HSPA8 [inhibition] USP9X GPSM1 [inhibition] IRS4 YWHAH [activation] CD79A LYN [activation] TRAF6 CS [activation] WASF2 PSTPIP1 [activation] CTSG SERPINA1 [inhibition] BCAR1 BCAR3 [activation] ZNHIT6 ETS1 [activation] REPS1 NUMB [activation] MST1R RELA [activation] CDC25A NFYA [activation] YWHAZ PRLR [inhibition] NOD1 NUDCD3 [activation] ATP13A2 ICAM2 [activation] TP53 BAG2 [activation] DNAJC8 SRPK1 [activation] MYC SHE [activation] TP53 RPS24 [activation] PPP1R9A ACTG1 [activation] BMP7 NOTCH2NL [activation] RPL36 ICAM1 [activation] WASL CRK [activation] TAF11 RXRA [inhibition] LSP1 SNAI1 [activation] RB1 STAT3 [activation] NFKB1 PPME1 [activation] BRD7 IRF2 [activation] NOX4 TLR4 [activation] TRAF3 RIPK1 [activation] PPBP MAPK6 [activation] CSNK1E DVL2 [activation] CD81 NCL [activation] PAXIP1 LUC7L2 [activation] ERN1 SRPK2 [activation] LPL LMF1 [activation] ARFRP1 CYTH1 [activation] PLCG1 FGFR2 [activation] RUNX1 DNMT1 [activation] MAPK11 OBSL1 [activation] E2F1 NCOA3 [activation] PREP OXT [activation] NR3C1 CD3D [activation] TRAF6 HNRNPL [activation] DNAJA2 SMAD3 [inhibition] MAPK3 GMFB [activation] PRKCI ADAP1 [activation] PRKAR1A PRKACB [activation] CSNK1D SMAD4 [activation] HTR1B HTR1D [activation] VIM CASP9 [inhibition] SNTA1 RYR2 [activation] CRMP1 ZAK [activation] NR2C2 AR [activation] HSPD1 AURKB [activation] SRPK1 YTHDC1 [activation] SGK494 PSTPIP1 [inhibition] RASL11B APP [activation] BRINP1 RAC1 [activation] SHC1 ATAD3B [activation] 页 280 共 454


2016/4/8 19:14

DRD3 SLC9A3 [activation] SRC TNFRSF11A [activation] NR4A2 BAZ1B [activation] APC LAMA3 [activation] PAXIP1 RNMTL1 [activation] AKT1 MAPKAPK2 [activation] SUV39H2 CCDC37 [activation] NXF1 BUB1 [activation] GNAI1 CCR5 [activation] MYF5 TCF3 [activation] APC CGNL1 [inhibition] PIK3R1 DOK1 [activation] MRPS6 SREBF2 [activation] RAN XPO6 [activation] ITSN2 FASLG [activation] MCM3 PTP4A3 [activation] PAK1 CSNK2A2 [activation] ATM RAD51 [activation] PLCG1 AIRE [activation] SETDB1 FAM118B [activation] EGFR ANKS1A [activation] RELA MYC [activation] SRPK2 PCBP1 [activation] ARPC4 ELAVL1 [activation] NOXA1 MAPK11 [activation] WDR5B KMT2D [activation] EPOR VAV1 [activation] CHMP2A TGFB3 [activation] JUNB USP24 [activation] FERMT3 APP [activation] C1QA PPP1CC [activation] TWF1 BMPR2 [activation] CRK PCDHA11 [activation] YAE1D1 MCF2L [activation] TRAF3 SUMO1 [activation] ALK CDK13 [activation] PIK3R2 CSF1R [activation] KIF11 ULK2 [activation] DLX4 GRB2 [activation] DHX36 RPA1 [activation] SMURF1 SMURF2 [inhibition] CACNA1A CALM1 [activation] GRB2 GSN [activation] MYL12A YWHAZ [activation] IFNA4 ALDOA [activation] CCND2 NPDC1 [inhibition] MAPKAPK2 ESR1 [activation] SERBP1 TP53 [activation] MAPK1 MAP3K3 [activation] ERBB2 VAPB [activation] ARHGEF7 YWHAG [activation] GRM1 ADORA1 [activation] HIST1H4A DNAJC9 [activation;inhibition] ASS1 ARAF [activation] PTPN6 CASP8 [activation;inhibition] HSP90AA1 PTK6 [activation] CDC5L TLN1 [activation] GABARAPL1 SRPK2 [activation] EPHA10 CAMK2D [activation] FHL2 CAPN1 [activation] IL4R IRS2 [activation] TP53 HECW1 [activation] EP300 IFNAR2 [activation] TP53 PRRC2C [activation] MAD1L1 UBTF [activation] GABARAP IPO5 [activation] CDC23 NOTCH1 [activation] CAV1 PPP1CA [activation] NLRX1 TRAF3 [activation] FZR1 RAD17 [activation] OGT ASH2L [activation] TXN2 KRT40 [activation;inhibition] ICAM1 RPL13A [activation] HIST1H3A CRTC2 [activation] MYC FERMT3 [activation] BMP15 BMPR1B [activation] 页 281 共 454


2016/4/8 19:14

BDNF ESR1 [activation] RANBP1 LRRK2 [activation] SHC1 MYO1C [activation] NME5 RELA [activation] CD81 EIF4A2 [activation] TP53 POLA1 [activation] SENP1 APP [activation] TSC1 RASSF7 [activation;inhibition] MAP4K1 TMEM101 [activation] ACVR1 ENG [inhibition] PACRG DNAJA1 [inhibition] NXF1 NFYA [activation] SP1 YY1 [activation] SUMO3 PPP2CA [inhibition] THPO NUMBL [inhibition] SYK RPS6KA2 [activation] DHX40 G3BP1 [activation] PDS5A WHSC1 [activation] MAP4K1 ABL1 [activation] MAP2K7 CFLAR [activation] MYB TAL1 [activation] ACVR1B SMAD2 [activation] CDH1 TNS3 [activation] ILF3 CSF2 [activation] BTK PIK3AP1 [activation] PTP4A3 DNAJC11 [inhibition] LAT CBL [activation] PRKCB PEBP1 [inhibition] ST6GALNAC6 MYC [activation] PLK1 SIMC1 [activation;inhibition] FOSL1 NME7 [activation] ARRB1 ACTB [activation] UBE2E2 SRPK1 [activation] MFN2 LRRK2 [activation] APP GABRA4 [activation] TGFB1I1 PXN [activation] CEBPA SMAD4 [activation;inhibition] KIR2DS1 HLA-C [activation] HSF1 HSF4 [activation] PPP1R13B EP300 [activation] ACTA2 CFL1 [activation;inhibition] CDKN1B CASP8 [inhibition] HSPG2 GRN [activation] ATF4 NFE2L1 [activation] IRF3 SOCS1 [inhibition] TP53BP2 GRB2 [activation] PLK1 KIF23 [activation] HIST1H2BC RAD51B [activation] SRPK1 IFIT5 [activation] CCNA2 CDC27 [activation] PRKAB2 PRKAA1 [inhibition] EGFR C9orf156 [activation] SMAD4 TFE3 [activation] OSTF1 ACTB [activation] KAT2B SATB1 [activation] EGFR ARHGAP1 [activation] MAPK11 BCL2 [activation] MPDZ CAMK2A [activation] LAMTOR4 MTOR [activation] MDM2 PBX1 [activation] HSPA5 SRC [activation] TRIM24 BRCA1 [activation] RASA1 HSPD1 [activation] FYN CENPV [activation] PRMT5 GRB2 [activation] MTOR PRR5 [activation] CASP3 IL16 [activation] ATP1B1 PAXIP1 [activation] HDAC1 RB1 [inhibition] TRPC4AP IKBKB [activation] UGT1A10 UGT1A8 [activation] CCHCR1 ABI2 [activation] CARD16 RIPK2 [inhibition] TLE3 NLK [inhibition] MARCH8 TFRC [activation] CBL EGFR [activation] 页 282 共 454


2016/4/8 19:14

TRAF2 CCHCR1 [activation] CYBB RAC1 [activation] EP300 CFH [activation] PIH1D3 CDKL3 [activation] SPERT ARMC7 [inhibition] RB1 ANAPC2 [activation] FYN CD36 [activation] HSPB1 GUCA1A [inhibition] USP20 VAPB [activation] RXRB ATP5I [inhibition] EPPK1 STK4 [activation] PRKCB EP300 [activation] RFTN1 BTK [activation] MYC DNAJB6 [inhibition] POLR2A YAP1 [activation] CD2BP2 LRRK2 [activation] FANCA IKBKB [activation] FOXA1 RARA [activation] EP300 E2F5 [activation] CYCS HSPA8 [inhibition] GEM RUNDC3A [activation] DEPDC1B MDC1 [activation] CIB1 CDK4 [inhibition] IRF5 CREBBP [activation] MYH3 ICAM1 [activation] PIAS2 CCHCR1 [activation] FYN NFASC [activation] CEBPB ATF4 [activation] MAD1L1 CDC27 [activation] KIF23 ENO1 [activation] EGFR APEX1 [activation] RPS6 RAD21 [activation] SKP2 ESR1 [activation] EP300 ACSM5 [activation] TGFB1I1 FKBP1A [inhibition] GRB14 NFKB1 [activation] RXRA RAD54L2 [inhibition] CDC42BPB MYO18A [activation] TPI1 MDM2 [activation] ZAP70 NFAM1 [activation] ZNF302 TP53 [activation] INSIG2 RNF139 [activation] SMAD4 ARFRP1 [activation] PDCD11 WHSC1 [activation] JUNB BATF [activation] ETS1 SCOC [activation] KMT2A BMI1 [activation] SERTAD1 EGLN3 [activation] TOP1 EGFR [activation] PDE4DIP PRKACB [activation] DDR2 CDH1 [activation] ZAP70 CD4 [activation] ACTG1 TRAF6 [activation] YWHAZ MAP3K3 [activation] ENO2 IL17B [activation] PLXNA1 AKT1 [activation] PPP2R5E PPP2CA [activation] BRD4 C7orf25 [activation] ADORA2A DRD2 [activation] IKZF3 FOXP3 [activation] GNG12 EIF4A2 [activation] TNF TRAF2 [activation] RBL1 SUV39H1 [activation] MYC TOP2A [activation] MCM7 PRKCD [activation] CTNNB1 PXN [activation] PRKCZ HIST3H3 [activation] APP GNAZ [activation] XPOT CAMKK2 [activation] MAP1LC3B MMP2 [activation] KTN1 RHOG [activation] SOCS1 MAP3K5 [inhibition] CDK2 HSP90AB1 [activation] FLNC FYN [activation] SMAD5 RYR2 [activation] FHL2 RUNX1 [activation] 页 283 共 454


2016/4/8 19:14

SIRT1 KCNA4 [activation] ATF3 NFKB1 [activation] ERBB3 BCAR3 [activation] H2AFX TP53BP1 [activation] FRK HSP90AB1 [activation] FBXL17 SUFU [activation] GRB2 IL5RA [activation] RGS4 CHRM3 [activation;inhibition] PTPRJ HEMGN [activation] HIST1H2BB CREBBP [activation] LZTS2 CDC23 [activation] CREM HDAC1 [inhibition] DERL1 CD3D [activation] CCL5 BCAR3 [activation] MBP STK39 [inhibition] CAD TAB2 [activation;inhibition] CCNJ CDK2 [activation] HSP90AA1 HSPB1 [activation] TGFBR1 RRH [activation] TWIST1 TWIST2 [activation] GAS7 WAS [activation] ATP7A UBC [activation] ITGB2 ICAM4 [activation] NGFR BFAR [activation;inhibition] ERO1L ATF2 [activation] GRB7 LY6G6F [activation] PID1 LRP1 [activation] OGT TET3 [activation] MSX1 RGS7 [activation;inhibition] IRF7 INSR [activation] GRB2 AIRE [activation] CASP9 MAPK1 [activation;inhibition] TFF1 FGFR2 [activation] PRKACA BRAF [activation] BRCA2 FANCE [activation] CRK HEXA [activation] PCNA EP300 [activation] CDKN2A NXF1 [activation] TBC1D16 RGS17 [activation;inhibition] CRK PCDHA3 [activation] TGFA GORASP1 [activation] TTC39C HSPB1 [activation] SARS2 TP53 [activation] KPNA2 RELA [activation] RASSF1 MAST2 [inhibition] YWHAH CRTC1 [activation] TP53BP1 FASN [activation] NDRG1 EIF2S3 [activation] MLLT4 DBN1 [activation] FGFR1 NCK1 [activation] TIRAP DNAJC3 [inhibition] SRPK1 C11orf52 [activation] AKT2 CASP3 [activation] RNF144A E2F1 [activation] SMURF1 CCDC88C [inhibition] PIK3R1 EFS [activation] DRD2 CLIC6 [activation] CDK5R1 CDK5 [activation] ITPKC TP53 [activation] GRIA2 DRD2 [activation] LAMTOR5 RRAGB [activation] TP53 ZIC3 [activation] MAPK4 GAB1 [activation] SRPK2 ZRANB2 [activation] MAP2K1 APC [activation] PPP2R2A SMURF1 [inhibition] RIPK2 TLR2 [activation] CD82 EGFR [activation] POU1F1 CEBPD [activation] PARP2 GNAQ [activation] NBEA FYN [activation] ITGB4 S1PR3 [activation] TF RYR1 [activation] DSG2 EGFR [activation] PIK3R2 CORO1C [activation] CUL7 MAPK14 [activation] 页 284 共 454


2016/4/8 19:14

TLX1 PKNOX1 [activation] MLH1 LGALS4 [activation] TRAF2 MAVS [activation] BLM FANCD2 [activation] IKBKB MAP3K14 [activation] BMX HSP90AB1 [activation] FADD TNFSF10 [activation] GABARAP PRKAA1 [activation] PTPRJ MAPK1 [activation] CCDC114 TXN2 [activation;inhibition] GH1 BMP1 [activation] MYB NCL [activation] DDX39B EIF4A3 [activation] SAT2 TGFBR1 [activation] PTPN1 PTK2 [activation] PTK6 KHDRBS2 [activation] DUSP6 TEX11 [activation] RPS16 LRRK2 [activation] FGF2 CD44 [activation] TP53 CLTB [activation] MYD88 SMAD6 [activation;inhibition] TTLL12 VCAM1 [activation] SUMF2 CACNA1A [inhibition] GMPPA GABARAP [activation] PTPN4 GRB2 [activation] YWHAZ ESR1 [activation] YTHDC1 DVL3 [activation] TP53 BTK [activation] ANXA5 IFNGR2 [activation] ETS1 MEIS1 [activation] PIM2 HSP90AB1 [activation] ESR1 MTA1 [activation] RAD21 SERPINB1 [inhibition] COL1A1 MMP2 [activation] IPO5 CAB39 [activation] PTPN1 NTRK1 [activation] SOX10 POU5F1 [activation] SMARCA4 MDM2 [activation] NOL9 MYC [activation] CDC5L EIF2S3 [activation] STK4 ARF4 [activation] HSPB1 NFU1 [activation] MSX2 DLX5 [activation] PLD2 LCK [activation] LDLRAD1 GIMAP5 [activation] MRPL50 MDM2 [activation] TRAPPC11 TP53 [activation] STK11 KLK7 [activation] RXRB KLHL11 [inhibition] MAPK10 MCL1 [activation] BCL3 HDAC3 [activation] FYN CACNA1F [activation] EGFR CAP2 [activation] CD5 PTPN6 [activation;inhibition] PFKFB3 EGFR [activation] CDC20 AURKB [activation] PSEN1 IRAK2 [activation] STX6 GOSR2 [activation] RPS6KA3 RPS6KA1 [activation] PLCG1 CAV1 [activation] TES ARAP1 [activation] TEX9 CCDC112 [activation] STRAP TRAF6 [activation] BUB1B BUB1 [inhibition] RPS14 LRRK2 [activation] MAPK14 DDX26B [activation] RNH1 MYC [activation] EP300 GTF2B [activation] RHOA GMIP [activation] ROS1 PTPN1 [activation] AIF1 LCP1 [activation] IRAK3 ATP6V0B [inhibition] TSC1 DAPK1 [inhibition] DVL1 ANXA7 [activation] RPS6 RICTOR [activation] GCN1L1 TSC22D1 [activation] 页 285 共 454


2016/4/8 19:14

CHD8 RBBP5 [inhibition] ACTN1 APC [activation] CNOT7 STAT1 [activation] ADRB2 RAN [activation] HSPD1 PCK1 [activation] C6orf165 RNF138 [inhibition] METTL21C HSPA1L [activation] CSN2 CDK1 [activation] MMP25 MMP2 [activation] FST BMPR1A [inhibition] SKIL ZNF106 [activation] HLA-G LILRB1 [activation] EZR ARF6 [activation] GAB3 SRC [activation] REV3L HDAC4 [activation] ENAH RPS6KA1 [activation] SRSF10 YWHAG [activation] SDCBP TGFA [activation] RXRA NR0B2 [inhibition] FBXL12 A2M [inhibition] IL1B ELAVL1 [activation] MLH1 PPP3CC [activation] ISL1 CDKN2B [activation] HDAC1 SKIL [activation] YWHAG PPP1R12A [activation] PYHIN1 ATRX [activation] PELO EGFR [activation] CDKN1A AMOT [activation] CDK1 EZH2 [activation] VRK3 AIM2 [activation] HMOX1 CREB3 [activation] RNF19A RPS6KA5 [activation] CTSB PLAU [activation] RARA HDAC4 [activation] RAF1 NUDCD3 [activation] PGM1 UBA5 [activation] HNRNPA1 PLOD2 [activation] MAPKAPK5 MAPK1 [activation] TOP3A FANCG [activation] PPARA FOXA3 [activation] MAPK1 TTN [activation] RAD21 DEK [activation] RHOD PLXNA1 [activation] PHLDA3 RFC2 [activation] SMARCC1 AURKB [activation] ITGA4 ESYT1 [activation] CD200R1 CD200 [activation] PTPN12 GHR [activation] DYRK1A NXF1 [activation] KCNA4 KCNA5 [activation] HUS1B FKBPL [activation] MSH6 NBN [activation] NTM APP [inhibition] EPHA1 ALK [activation] PTK2B IL7R [activation] STAT5A CRK [activation] GEM IKZF3 [activation] TNFRSF14 TRAF2 [activation] CD2 LCK [activation] TRAF6 TRIM28 [activation] ITGB2 VNN2 [activation] CFL1 PLD1 [activation] USP7 NOTCH1 [activation] C9orf163 LRRK1 [activation] MAPK3 RPTOR [activation;inhibition] MAPT YWHAQ [activation] ING1 TP53 [activation] RICTOR PRKCZ [activation] VWDE FBXO6 [inhibition] SPATA31A3 RELA [activation] NBN ATRX [activation] CTNNB1 VHL [inhibition] ABL1 SHD [activation] EP300 DDIT3 [activation] EIF4E2 APP [inhibition] TAB1 NXPH3 [inhibition] 页 286 共 454


2016/4/8 19:14

TRIM28 NR4A1 [inhibition] XYLT1 MYC [activation] FYN TULP4 [activation] VCAM1 EIF4G1 [activation] GABARAP ZC3HAV1L [activation] F2RL2 JAM3 [activation] CEBPB CREBBP [activation] KDR PDGFRB [activation] LRRK2 EPS8L2 [activation] EGFR AHNAK [activation] MEF2C MAPK14 [activation] DDX56 TTN [activation] ACTB NCF1 [activation] OPTC CRK [activation] BMP6 NCOA3 [activation] HIST2H2BE STK4 [activation] SMAD2 DCUN1D1 [activation] TRAF6 ST13 [activation] EP300 RARA [activation] RAC1 CCDC104 [activation] CCSER2 NDEL1 [activation] AMOT YAP1 [activation] NLGN3 DLG2 [activation] RASSF1 MAPK8 [inhibition] TGFBR1 HMMR [activation] PDGFB MDFI [activation] TNFRSF1B FANCD2 [activation] DAXX HSF1 [activation] HIST1H2BD YWHAZ [activation] TNF UBC [activation] RAD50 AIM2 [activation] EIF4G1 TRAF2 [activation] SLC2A2 PDX1 [activation] SLC41A3 MAPK6 [activation] CCND1 IFI27 [inhibition] GLI1 VHL [inhibition] TP63 GRB2 [activation] TGFBR2 RCVRN [inhibition] YWHAB SLC8A3 [activation] ERBB4 PTPN11 [activation] MYC TENM2 [activation] FZD2 UBC [activation] EGFR PHGDH [activation] CBL CAPN1 [activation] GRB2 AKAP2 [activation] VCAM1 DDX17 [activation] RAC1 CHN2 [activation] YWHAE PRPSAP1 [inhibition] JUN ETS2 [activation] SP1 NCK1 [activation] TNF TRADD [activation] GPRASP2 BARD1 [activation] MET ABL2 [activation] GABARAPL1 ENO2 [activation] RAD54B GMCL1 [activation] HSP90AB1 AURKB [activation] PLCG2 LAT [activation] DNAJA3 ALS2CR11 [inhibition] RHOC FAM65B [activation] AURKB BIRC5 [activation] GPR20 JAM2 [activation] UBXN7 HIF1A [activation] BRAF HSPA9 [activation] C8orf33 KCTD6 [activation] NFYC TP73 [activation] FES RASA1 [activation] STAT3 NLK [activation] UBE2H MRPL38 [activation] YWHAH ARRB2 [inhibition] CCL3L1 CCR3 [activation] SPERT MMAB [activation] CYTH4 TRIM54 [activation] USP7 RPA1 [activation] ABI2 CCDC36 [activation] NXF1 AHCTF1 [activation] EGFR RAPH1 [activation] 页 287 共 454


2016/4/8 19:14

LCP2 CBL [activation] RAC1 ALS2 [activation] ACVR1 SMURF1 [inhibition] ARRB1 ATR [activation] AGAP2 STAT5A [activation] TP73 CDK1 [activation;inhibition] YWHAZ EIF4A3 [activation] YWHAZ ABL1 [activation] TRIM15 MYBL2 [inhibition] MCM6 MCM8 [activation] ICT1 MRPL50 [activation] RHO DNAJB2 [activation;inhibition] HSPA8 TRADD [activation] NXF1 MAD2L2 [activation] ATRIP PRKDC [activation] SERPINI1 PLG [inhibition] ANXA7 CHGB [activation] ATF1 SPI1 [activation] BMP4 ZFYVE9 [activation] PTPRF TRIO [activation] YPEL2 SRPK1 [activation] EGFR RPA2 [activation] PRMT1 ARPC3 [activation] CCDC149 PRNP [activation] DVL1 HDHD2 [activation] CDKN1A CKS2 [activation;inhibition] RAB5A APPL2 [activation] FASN TP63 [activation] DDX27 GABARAP [activation] PLK3 PTPRC [activation] HIST2H3A DNMT3L [activation] EIF2S2 CCDC90B [activation] BMPR1B CDK14 [activation;inhibition] SETD5 TRAF2 [activation] HSPB1 ATF2 [activation] WIPI2 GCN1L1 [activation] HSP90AB1 DLX6 [activation] ERBB2 CRK [activation] CYBB NCF1 [activation] PRKCB TIAM1 [activation] MMP14 CCL7 [activation] ITGA4 IGF2BP2 [activation] ITGA2 KDR [activation] CSF3R JAK1 [activation] DIRAS3 APC [activation] PIK3R2 CBLB [activation] CDK3 E2F2 [activation;inhibition] CREBBP DYRK1A [activation] APC STRN4 [inhibition] ARHGEF1 CNKSR1 [activation] GABARAP HLA-B [activation] PPP1CA MAX [inhibition] FAM98A GABARAPL2 [activation] ACTG1 TRAF3IP1 [activation] USP20 NUP153 [activation] EZR CDK5 [activation] USP29 TP53 [activation] RIBC2 JUP [activation] NUP50 NUP153 [activation] NR3C1 TP53BP1 [activation] LEF1 MYB [activation] MAPKAPK2 PINX1 [activation] EP300 HIST1H1A [activation] ACTG1 FHOD1 [activation] RHEBL1 TXNL4A [activation] YWHAZ VCAM1 [activation] VCAM1 U2AF2 [activation] SUMO1 DDX39B [activation] RPS20 GRB2 [activation] CREBBP RPS6KA1 [activation] UCN2 IL10RB [activation] OPRM1 PLD2 [activation] APP EIF2S2 [activation] NKD2 TGFA [activation] SMAD4 CDC14B [inhibition] SHC1 CSF3R [activation] 页 288 共 454


LRRK2 MPC2 SRPK1 ZNF444 PTPRC RNF11 SMARCA4 STAT2 G3BP2 ARRB2 HMMR IL24 NCK2 KIT GNAQ PECAM1 GNAI1 GPR50 MIF CUL7 FST DIP2A RPA3 PKIG EIF5B MAPK13 HAP1 STX5 SEMA4A PLXND1 HSPB1 TOMM70A NCK1 ABL2 EP300 ING2 SRGAP2 MYO1G DRD2 NCS1 SMAD1 SMAD5 PRKRA ESR2 DPYSL5 DPYS VCAM1 ITSN2 FOXP2 FOXP1 IGF1R DOK4 PIKFYVE APP IRAK4 ARNT FYN DLGAP4 JAK1 IL27RA RAC3 XIAP LRG1 TGFBR2 PRDX3 MAPK3 NBN UBE2A ATM RRM1 MYC FHL2 PRKACA RHOA PIK3R1 LIG3 UBC CD3E NXF1 YAP1 EXOC3 EXOC4 ESR1 PRKDC YWHAH NCOA3 MAML1 NOTCH4 CEBPB HSF1 SMARCA1 BAZ1B CD5 CD247 MAP9 AURKB TRAF6 HYOU1 PPM1B SUMO3 PLCB3 PARD3 LONP1 MYC TLN1 ITGA1 RPA3 HELB SCYL2 RAPGEF2 PRRC2C AURKB ESR1 MARS C18orf8 NOTCH1 CENPT APP CDKN1A A2M MME VIP PTH1R ARRB1 HRAS CDC25A CALM1 HLA-C ANKRD28 DNAJB1 SH3PXD2A TRAF6 SDCBP FANCL FANCG SMAD4 ISG15 EGFR CDH5 EP300 CTF1 AMER3 APC SRPK2 MAB21L2 YWHAB SAMD4A MTBP MDM2 STAT4 TRIM28

2016/4/8 19:14

[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] GRB2 [activation] [inhibition] [activation] [activation;inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] 页 289 共 454


2016/4/8 19:14

ELMO2 GRB2 [activation] RAF1 CDC25B [activation] DPYSL2 PLD2 [activation] MDN1 CASP4 [activation] UBE2E2 RNF25 [activation] SUV420H2 HSPA4 [activation] CTCF RAD21 [activation] HSPB1 GABARAPL2 [activation] TRAF6 CBL [activation] PRKCD PPP1CA [activation] MAPK1 MBP [activation] SUMO3 CASP3 [activation] PPP2R5A PPP2R1B [activation] TP53 CABLES1 [activation] JAK3 CD247 [activation] IPO5 NOTCH1 [activation] RAD50 HNRNPA1 [activation] H2AFX TPT1 [activation] GSN STK39 [activation] EPOR CISH [inhibition] YWHAG KIAA1598 [activation] NRAS FBP2 [activation] TRIM23 UBE2E2 [activation] A2M NGF [inhibition] CASP7 STAT1 [activation] NDUFA4L2 ANXA9 [activation] HCK AGK [activation] HSPB1 YWHAE [activation] KMT2B GRB2 [activation] TESK2 CFL1 [activation;inhibition] RPS17 TP53 [activation] ASS1 ASCC2 [activation;inhibition] FCGR2A SHC1 [activation] FAM208B CCNG2 [activation;inhibition] YIPF1 NXF1 [activation] PRTN3 ELN [activation] HSP90AA1 CAMK2D [activation] STX12 SNAP25 [activation] DMC1 GORASP2 [activation] ARHGEF5 SFN [activation] AKT1 AHSG [inhibition] EEF1A2 STK4 [activation] PAXIP1 PPIA [activation] ITGA4 TOP1 [activation] LUC7L2 CDK4 [activation] TIAM2 ANXA7 [activation] DOCK5 GRB2 [activation] AMOT PRKCI [activation] GHRH FAP [activation] DOK1 RET [activation] ARMC6 ILK [activation] RCC2 ATG5 [activation] BID RPA2 [activation] NRP2 NRP1 [activation] MYC FASTKD1 [activation] HDAC3 GATA1 [activation] GP6 FCGR3A [activation] SRPK1 TAF1B [activation] GNA14 CCR1 [activation] MAP2K3 MAPK8IP3 [activation] CDK5 WASF1 [activation] FASN EIF4A3 [activation] BTK JAK1 [activation] SMAD2 DOCK9 [activation] ARHGEF7 ERBB2IP [activation] IRF5 GTPBP1 [activation] TP53 COPS3 [activation] PIK3R1 FLNC [activation] HIST1H4A SUV420H2 [activation] CXCL9 BMF [activation] DPYSL2 LEF1 [activation] LIMK1 PXN [activation] PRKG1 SMAD4 [inhibition] CUEDC2 IKBKB [activation] SRC TLR3 [activation] EGFR PRKAA1 [activation] 页 290 共 454


2016/4/8 19:14

ACTB SSH1 [activation] ADRBK1 PRKACA [activation] RAPGEF1 NXF1 [activation] MET YWHAZ [activation] PRKCZ AKT1 [activation] STAU1 RAC1 [activation] DAPK1 MCM3 [activation] SOS2 ITSN2 [activation] CBLB DDR2 [activation] HDAC4 YWHAB [activation] XRCC1 RAN [activation] FANCE FANCF [activation] PRKCD IRAK1 [activation;inhibition] ATG5 RALB [activation] PDHA1 ADRB2 [activation] PRKCB BMPR2 [activation] C1R PCK1 [activation] TP53 CDC25C [activation] FBP2 PIK3CA [activation] TGFB3 TGFB2 [activation] VAPB OSBPL10 [activation] MBL2 CALCR [activation] STK4 NCCRP1 [activation] ERO1L FBXO6 [activation] BLK FCGR2B [activation] G3BP1 EIF4G1 [activation] TNS3 EGFR [activation] NUDC SCAP [activation] NXF1 CCNI [activation] ENO1 BCL6 [activation] GRB2 CBLC [activation] ITGA4 LYN [activation] HUNK GRB2 [activation] SRPK2 TMEM14A [activation] HN1L EGR2 [activation] EP300 PRKCA [activation] HSPB1 NOS2 [activation] APP ZFYVE16 [activation] LRRK2 DVL2 [activation] CFLAR RIPK2 [inhibition] TGFBR2 PIK3R1 [activation] JUN STAT6 [activation] SMAD3 BTRC [inhibition] PCK1 YWHAQ [activation] HIST3H3 MDM2 [activation] KDR DNM2 [activation] GRB2 GSTM3 [activation] TRIM28 WHSC1 [activation] IL2RB RAF1 [activation] HTT CASP3 [activation] CHAC1 RHOXF2 [activation] EGFR GNAS [activation] PLD1 RPS6KA3 [activation] GATA1 MAPK3 [activation] TP53 PAFAH1B3 [activation] VWF COL1A1 [activation] STK38L YWHAB [activation] FYN CCR10 [activation] MLH1 KPNA2 [activation] ALB APOC3 [inhibition] CDC42EP3 RHOQ [activation] JUN NCOA3 [activation] FYN CD79B [activation] EPB41L2 WNK1 [activation] GIT2 GUSB [activation] IGF2BP1 BIRC2 [activation] PIM1 CDC25A [activation] PRKD1 MAPK13 [activation] PRKD1 MAPK8 [activation] GADD45B PPARA [activation] DAG1 SRC [activation] PDGFB ART1 [activation] PLCG1 INSR [activation] RAP2A RALGDS [activation] DRD5 GNA13 [activation] CFTR ACTB [activation] 页 291 共 454


2016/4/8 19:14

GRK5 RHO [activation] SMC4 FBXO6 [activation] DOCK2 NOTCH2NL [activation] KIR3DS1 HLA-B [activation] PLCG1 TRPC3 [activation] TRAF6 MALT1 [activation] CTTNBP2NL STK4 [activation] SMAD2 PAXIP1 [activation] YAP1 WWTR1 [activation] ATG14 PIK3R4 [activation] BCL2L11 CISH [activation] RUNX1 CEBPB [activation] ITGA4 TOP2A [activation] STAT3 PIM1 [activation] VKORC1 IFITM3 [activation] MYB MAPK11 [activation] ERBB3 PTK6 [activation] ANAPC15 ANAPC1 [activation] SPI1 CEBPA [inhibition] PPARA NCOA3 [activation] CLNK ERBB2 [activation] YWHAG CRTC1 [activation] RGS4 COPB2 [activation;inhibition] BTRC RAP1GAP [inhibition] MAPK1 HIF1A [activation] SCARF2 FYN [activation] IKBKG CREBBP [activation] NTRK3 MAPK1 [activation] CPVL CTNNBIP1 [inhibition] CASP5 NLRP1 [activation] ATF4 JUN [activation] HIF1A ARRB1 [activation] CBL TNFRSF10A [activation] GPSM1 INSC [inhibition] KCNB2 KCNB1 [activation] CREBBP RUNX1 [activation] SMAD5 HBG2 [activation] BARD1 BCL3 [activation] SUMO3 DNAJC8 [inhibition] RASA1 CDKN2A [activation] NFKB1 CD82 [activation] CAMK2G ACTN4 [activation] SCAND1 MAPK3 [activation] PER1 PER2 [inhibition] PPP2R1A ESPL1 [inhibition] IL1B APP [activation] BRCA1 SMARCA4 [activation] BBC3 BCL2L1 [activation] MAPK9 NFE2L2 [activation] SERPINF2 PLG [activation] PRKACA AANAT [activation;inhibition] ERBB2 STAT1 [activation] ANXA2 ESR1 [activation] ELAVL1 CDC23 [activation] APOE RHEB [activation] FOXO1 FHL2 [activation] RBPJ GSK3B [inhibition] SP1 AR [activation] FBXO6 TTC4 [inhibition] PTK2B SH2D3C [activation] DDX18 ESR1 [activation] FCHSD1 ITSN2 [activation] KLHL42 USHBP1 [activation] MAPK3 BLVRA [activation] STAP2 BMP4 [activation] DYNLRB1 BCL2L1 [activation] ETV5 LRRK2 [activation] DNM3 GRB2 [activation] SUMO1 IGF1R [activation] HSF1 HSF2 [activation] CASP3 SRF [activation] ATF4 GCC1 [activation] RAC2 ACTB [activation] HMGA2 HDGF [activation] EGFR MST4 [activation] ESM1 ITGB2 [activation] 页 292 共 454


2016/4/8 19:14

SSH1 DSTN [activation] KPNA3 RELA [activation] VTI1B TNK2 [activation] IKBKG CHUK [activation] EHMT2 CEBPB [activation] HIST2H3A LALBA [activation] CNP PRNP [activation] AMBP A2M [inhibition] RAB11FIP2 RAB11A [activation] EPHA2 CDH5 [activation] SMARCA4 MYOG [activation] CD79A PTPN6 [activation;inhibition] CAD MAPK1 [activation;inhibition] CCNH GTF2H1 [activation] ERBB4 CD44 [activation] VAV2 CBLB [inhibition] PPP2CA STK25 [inhibition] TNK2 CSPG4 [activation] VCAM1 LY6G5B [activation] DYRK1A HIST1H3A [activation] CCDC155 STX5 [activation] PRKAG1 EGFR [activation] CEBPA CDX1 [activation] DLGAP4 ABL1 [activation] HSPA1L MAP3K7 [activation] EIF2S2 SUMO2 [activation] DNAJA1 HLA-B [inhibition] RPS6KA3 HIST3H3 [activation] PPP1CA IKBKB [activation] ARL8B PTBP3 [activation] RANBP2 CEBPA [activation] GKAP1 PRKG1 [inhibition] RPAP3 ANAPC1 [activation] TTF1 BAZ2A [activation] APOE SORL1 [activation] MET STAP1 [activation] IRAK2 HSP90AB1 [activation] RAP1B RASSF5 [activation] FBXO34 TGFBR1 [inhibition] KAT2B KLF10 [activation] CDK4 MARCKS [activation] PCNA RELA [activation] VPS52 PRKAA1 [inhibition] EP300 HOXB9 [activation] HSPA1A PTGES3 [inhibition] NUP62 KANSL1 [activation] PAXIP1 HSPA4L [activation] CRMP1 SRC [activation] CRK MAPK8 [activation] EGFR DOK4 [activation] CCSER2 STX1A [activation] ANAPC1 CDC27 [activation] SYK LAX1 [activation] MAPK8 NR3C1 [activation] PTK2 IRS1 [activation] RANBP1 XPO1 [activation] STX3 SNAP23 [activation] FAN1 PMS1 [activation] STK38 ARRB2 [inhibition] H1FX VCAM1 [activation] TP53 RRM2 [activation] IL24 AKT1 [activation] VDAC2 SNCA [inhibition] BMP4 HTRA1 [activation] PIK3R1 MAL [activation] EXOC6 NOS3 [activation] RASD1 NOS1AP [activation] LRPAP1 RALA [inhibition] MEP1A GNRH1 [activation] MIF COPS6 [activation] LRRK2 RAB32 [activation] SLC9A3R1 MDM2 [activation] MAPK8 MAP3K4 [activation] PARD6B YWHAZ [activation] SMARCA5 MYC [activation] SOX2 GCN1L1 [activation] 页 293 共 454


2016/4/8 19:14

NCK1 MYLK [activation] SRSF5 MAPK14 [activation] FAM102A SKAP1 [activation] PHLDA3 FASTKD2 [activation] AR MDM2 [activation] RAB11A PPP2R1B [activation] BAK1 ACTR2 [activation] F10 GGCX [activation] TRIM24 NR3C1 [activation] GADD45A GADD45GIP1 [activation] CD4 GAPDH [activation] TP53 ARL3 [activation] YWHAZ RALGPS2 [activation] PLK1 CCNB1 [activation] CUX1 KAT2B [activation] YWHAZ RPS6 [activation] UBE2H HIST2H2AA3 [activation] FOS MAP1B [activation] CASP8 TFCP2 [inhibition] UCN LEP [activation] NRAS STX17 [activation] PARVA ILK [activation] HNRNPL VEGFA [activation] CTNNB1 CDK6 [inhibition] ENO3 APP [activation] PIK3R2 NXF1 [activation] FXR2 SRPK2 [activation] ASB16 H3F3A [activation] APP GADD45G [activation] DYRK1A PRKACA [activation] GAPDH LAMA4 [activation] ATP6V1A VAMP7 [activation] CMKLR1 TPST1 [activation] BCAR3 BEX1 [activation] ATAT1 APP [activation] HSPA4L HSPA8 [inhibition] BANK1 YWHAZ [activation] SRC HDAC3 [activation] TP53 RABL6 [activation] BRD4 C8orf33 [activation] RAD21 EIF2S3 [activation] SMAD2 SIK3 [activation] SMAD3 RBL1 [inhibition] MAP3K2 HSP90AB1 [activation] ENO3 MTMR14 [activation] STAT1 RAC1 [activation] NOTCH2NL HCK [activation] RAD50 DDX1 [activation] TP53 KPNA4 [activation] ABL1 G3BP2 [activation] PTN KPNB1 [activation] IGF2 IGFBP1 [activation] TGFB1I1 CBLC [inhibition] KDR STAT1 [activation] WARS GBAS [activation] IGSF1 ACVR2A [activation] SCARB1 CUL1 [activation] BOLA2 VCAM1 [activation] ITCH NUMB [activation] ALK ACTB [activation] HTT PIAS1 [inhibition] EP300 RUNX1 [activation] BIRC2 TNFSF14 [activation] CTGF FGFR3 [activation] PRDX2 PSEN1 [activation] PPP1CA PPP1R3E [activation;inhibition] NR4A1 SRC [activation] ITGA4 GAPDH [activation] EP300 TCF12 [activation] TRAF6 MCM6 [activation] MITF EP300 [activation] SRPK1 ACIN1 [activation] LAMTOR5 YTHDC1 [activation] RPA1 CAV1 [activation] CHRNA5 CHRNB4 [activation] GRB2 NIF3L1 [activation] 页 294 共 454


2016/4/8 19:14

HIST1H2BN CD81 [activation] SRPK2 ACIN1 [activation] MTNR1B YWHAQ [activation] ROR1 EGFR [activation] GRB2 NFYB [activation] RASAL3 WNK1 [activation] GRB2 RAB6B [activation] PPP2CA PRKDC [activation] WNK1 SLC9A1 [activation] LAMA3 BMP1 [activation] TAGLN2 CDK2 [activation] FYN SHANK3 [activation] FYN PTPN4 [activation] EGFR SLA [activation] LYZ CRK [activation] TRAF3IP1 SMC2 [activation] GRB2 DDX17 [activation] TGFBR3 ARRB2 [inhibition] FER YWHAB [activation;inhibition] INSR CEACAM1 [activation] GTF2E1 SRPK2 [activation] PRKAA2 PRKAB1 [inhibition] OTUD4 DSG1 [activation] CASP4 CCDC59 [activation] MAPK3 GH1 [activation] RBL1 MAPK6 [activation;inhibition] RELA BANP [activation] TRAF5 TRAF6 [activation] DVL2 POLI [activation] APP AGER [activation] IRS4 AURKB [activation] PLK1 NUAK1 [activation] SRPK2 SON [activation] GNAI1 EPOR [activation;inhibition] CCL14 CCR3 [activation] GSN SRC [activation] GDI2 TNFRSF14 [activation] C11orf65 CALM1 [activation] KRTAP10-3 BMP7 [activation] RPRD1A BCAR3 [activation] PPBP CMTM6 [activation] YWHAB KIF23 [activation] PPARG FOXO1 [activation] TGFBR1 TGFB1 [activation] CDH7 CDH6 [activation] RAB28 APP [activation] TP53RK OSGEP [activation] SRSF1 SRSF5 [activation] WWC3 FTSJ1 [activation] XPR1 AMOT [activation] RAP1A RGL4 [activation] TGFBR1 PPP3CC [inhibition] RCC2 FTSJ1 [activation] UBE2I SLC9A1 [activation] ERBB4 ABL2 [activation] EEA1 CCDC8 [activation] PTPRJ TEK [activation] EIF4A3 RAN [activation] CCND3 DMTF1 [inhibition] TPT1 SPP1 [activation] TXNDC17 AVP [activation] CITED2 LHX3 [activation] HSPB1 GRB2 [activation] IRS4 RAF1 [activation] NR5A1 FYN [activation] RUNX2 SOX9 [activation] RELA STAT6 [activation] IFNAR2 IFNAR1 [activation] AXIN1 DAB2IP [activation] PPP1CC RPAP3 [inhibition] IKBKG F7 [activation] RIPK3 HSPA1L [inhibition] UCK2 VCAM1 [activation] HIST3H2BB RPS6KA5 [activation] FBXO6 LEPR [activation] SULT1E1 BMPR2 [activation] 页 295 共 454


2016/4/8 19:14

CASP8 MAP3K14 [inhibition] SLX4 ERCC4 [activation] RXRB NR1H3 [inhibition] SMARCD3 MAPK14 [activation] GNB1 BTK [activation] LATS1 MOB1B [inhibition] CACNA1A VWF [inhibition] IKBKG ARF6 [activation] FADD TNF [activation] CDK2 MYBL2 [inhibition] RPA1 C7orf50 [activation] INPP5D CRKL [activation] GNA12 TSHR [activation] NFE2L2 PRKCD [activation] GNB2 STAT5A [activation] BID EZR [activation] CTSG SELPLG [activation] CBLB PIK3R1 [activation] C1R C1S [activation] RPS6KA3 GSTK1 [activation] GMFG VANGL1 [activation] PRKCA CYTH2 [activation] BCL6 POU2F3 [activation] CDC23 PAXIP1 [activation] PACSIN3 SOS1 [activation] NUDCD3 KLHL6 [activation] CDC42 CLIP1 [activation] HOXB1 MEIS1 [activation] CDK15 CDK2 [activation] INSIG2 INSIG1 [activation] IRS1 YWHAE [activation] APP ARFGAP1 [activation] EIF3I SGK1 [activation] CD3G FYN [activation] VCAM1 ARPC4 [activation] EIF4A1 PAIP1 [activation] HGS YWHAB [activation] IFITM3 FYN [activation] MAPT SYK [activation] SMAD2 DDX3Y [activation] LCP2 BLNK [activation] STRAP SMURF1 [inhibition] EGFR MARS [activation] CYLC2 NRAS [activation] CDKN1A NRBP1 [activation] SRPK1 SRSF12 [activation] PRKDC CASP2 [activation] APH1A PSEN1 [activation] NXF1 C10orf76 [activation] BHLHE40 PPP2R1A [activation] ATM HDAC1 [activation] CPSF3 HSPB1 [activation] STRA13 FANCE [activation] SHANK2 GRB2 [activation] FCER2 ATF7 [activation] CDK11A A2M [inhibition] EFEMP2 HHEX [activation] PPP1R12A PTPRJ [activation] CTBP1 PLCB1 [activation] RAC1 NCK1 [activation] EIF2B2 EIF2B1 [activation] ENOX2 SNRPA [activation] PRDX2 BAD [activation;inhibition] ATF3 HSP90AB1 [activation] SPP1 RPL15 [activation] CMA1 IL1B [activation] RALBP1 CASP8 [activation] AFF1 KMT2A [activation] STK11 SIRT1 [activation] MFAP4 TP53 [activation] NUP62 OGT [activation] TDRD7 STK11 [activation] PPP3CA GRB2 [activation] PAX6 SMAD3 [activation] ANAPC4 SOX2 [activation] CDC42 VRK2 [activation] 页 296 共 454


2016/4/8 19:14

LRP5L PLK1 [activation;inhibition] SOS1 TNFRSF1A [activation] TP53 ACTBL2 [activation] VCAM1 SYK [activation] ABRA MYC [activation] HBEGF BCL6 [activation] MDM2 PHGDH [activation] CDON CDH15 [activation] GNAS JAK3 [activation] CSNK2A1 TP53 [activation] BCL6 NACC1 [activation] PLOD2 OS9 [activation] EIF2AK4 BAG2 [inhibition] YWHAB RALGPS2 [activation] NRP2 VEGFA [activation] CD93 CRK [activation] WAS PTPRB [activation] TNFSF14 DIABLO [activation] NLK C2orf44 [inhibition] ANKRD11 SRC [activation] BTK PRKD1 [activation] REM1 CACNB1 [activation] TTC1 HSPA8 [inhibition] PRMT5 VCAM1 [activation] HPR IGHM [activation] PUM1 FBXO6 [inhibition] NCOA1 NKX2-1 [activation] ESR2 CCDC25 [activation] OBSL1 TP53 [activation] TAOK2 GRB2 [activation] TSC1 TBC1D7 [inhibition] PRKAA1 FKBP5 [inhibition] TGFBR1 SMURF1 [inhibition] DGKD DYSF [activation] STRN3 STK24 [activation] PTPN1 GSK3B [activation] STK4 MCM7 [activation] VPREB1 LGALS1 [inhibition] INSC PARD3B [inhibition] CDKN1B GRB2 [activation] EPHA5 STAT3 [activation] NMT1 CAPN1 [activation] PNPLA6 NXF1 [activation] PDGFA COL6A1 [activation] SMAD4 FOXO1 [activation] ATG101 ATG5 [activation] SLC9A2 SRC [activation] TIMELESS ATRIP [activation] HIC1 TCF7L2 [inhibition] RASSF5 HRAS [activation] APP EPHB4 [activation] PIK3R1 SUV39H2 [activation] IRS1 CYTH3 [activation] EGFR SFXN3 [activation] XPO1 ATF2 [activation] NBAS HSPB1 [activation] KPNA2 JUN [activation] HSPA2 TTC1 [activation] SPI1 IRF8 [inhibition] CAPN7 UBL7 [activation] CTSG PPBP [activation] CASP3 MET [activation] EP300 ESR1 [activation] TNFSF10 RBM48 [activation] PDGFRB PTPRK [activation] NOTCH1 SMAD9 [activation] CAV1 VAV2 [activation] DOK1 ITK [activation] PRKCE HSP90AB1 [activation] AGFG1 APC [activation] SHARPIN IKBKB [activation] UBE2W UFM1 [activation] APOE CTSB [activation] SETDB1 ULK2 [activation] STAT3 NIF3L1 [activation] RBX1 CCND1 [inhibition] 页 297 共 454


2016/4/8 19:14

FAM194B CD247 [activation] MCM3 RAD21 [activation] MAPRE1 APC2 [activation] PLSCR1 SLC25A6 [activation] ANXA7 FGB [activation] INSR SH2B1 [activation] USP45 IGKV4-1 [activation] JUP PTPRJ [activation] SMAD5 PAX6 [activation] TP53 DAPK1 [activation] ELANE CSF3 [activation] ARF6 UBE2D3 [activation] KLRK1 HCST [activation] BCR TCF7 [activation] MLH1 EIF2A [activation] HMGA2 CSNK2A1 [activation] PTK2 TNS3 [activation] CUTA NR4A1 [inhibition] ACACA GABARAP [activation;inhibition] KIF23 ARF6 [activation] TWIST1 CDK9 [activation] PHYHIP PNPLA2 [activation] MTG2 TAB1 [inhibition] RPA3 WDHD1 [activation] SMARCA2 EPAS1 [activation] KAT2B SAT2 [activation] TNF SEC16A [activation] GIP GIPR [activation] HNF4A MAPK8 [activation] NR2F6 NR3C1 [activation] PRKCD PAK1 [activation] CDK14 ACVR1 [activation;inhibition] CCND1 MYBL2 [inhibition] NOTCH1 LRCH1 [activation] SMARCA4 HSP90B1 [activation] GRB2 FCGR2C [activation] SYN1 PAK1 [activation] SRPK2 FGF12 [activation] GP1BB LYN [activation] CCDC53 CCHCR1 [activation] ESR1 FTSJ3 [activation] ASCC2 LPL [activation] MAPK9 LAMA1 [activation] KCNA3 KCNA5 [activation] VCAM1 FASN [activation] RAB5A RABEP2 [activation] DEF6 ZAP70 [activation] EEA1 RABGEF1 [activation] PAXIP1 PAGR1 [activation] HSPB1 NCKIPSD [activation] STYXL1 EHD4 [activation] BCL2L1 BID [activation] ACVR1B SMAD4 [activation] JAK2 SH2B2 [activation] CAGE1 TBC1D23 [inhibition] NR3C1 NCL [activation] PLCB1 KRIT1 [activation] NUP98 EP300 [activation] TNFRSF10C BMX [activation] AKT1 MAP3K11 [activation] NGF ROR1 [activation] BRD4 CRK [activation] MDM2 PIM3 [activation] PAK1 HSP90AA1 [activation] VAPA STK4 [activation] SUV420H1 YWHAG [activation] SMURF2 RAN [activation] UBE2I TRAF3 [activation] NFE2L2 NCOR2 [activation] MIF ATG5 [activation] RECQL5 POLR2D [activation] CMBL SMYD2 [activation] AKT2 XIAP [inhibition] MYL6 HLA-B [activation] CSPP1 MYC [activation] ASB14 NOTCH2 [activation] 页 298 共 454


2016/4/8 19:14

QTRTD1 IGHA1 [activation] LIFR IL6ST [activation] HSPB1 TRIM24 [activation] ZBTB7A TP53 [activation] PRKCQ NFE2L2 [activation] JAK2 SKP2 [activation] VAMP7 UBC [activation] CUL1 CHEK2 [activation] HIF1AN MTPN [activation] CTNNB1 PTPN12 [activation] YWHAH NRIP1 [activation] TGFBR2 FANCC [activation] ARHGDIB ANKRD1 [activation] H2AFX ANXA4 [activation] PDGFB NRP1 [activation] PPARGC1A EP300 [activation] ATF3 CREBBP [activation] UBE2I MAP2K1 [activation] SORBS1 PAK2 [activation] APH1B PSEN1 [activation] MAPT SLC1A2 [activation] UNC13B WDR48 [activation] MTCP1 AKT2 [activation] TRAF3 IRF1 [activation] E2F4 CEBPA [activation;inhibition] PKDREJ ERBB2 [activation] PXN VCAM1 [activation] TNFRSF19 TRAF6 [activation] MOB1A TRAF6 [activation] SP1 SP3 [activation] NCOA1 STAT5A [activation] CASP10 MAP3K14 [activation] ADAM17 PDPK1 [activation] MYC GSG2 [activation] EP300 THPO [activation] NR2E3 HDAC1 [inhibition] PSPN GFRA4 [activation] PRKCD PRKCQ [activation] ATF4 TBP [activation] ARHGEF7 SRGAP1 [activation] CCND3 RBX1 [inhibition] ARHGAP17 BTK [activation] CEP55 NOS3 [activation] USP6 CALM1 [activation] RTEL1 RPA2 [activation] TEX36 PPP1CC [inhibition] YIF1A VAPB [activation] TNFRSF1A FASLG [activation] HSPA8 HSPH1 [activation] SUV39H1 RUNX1 [activation] RASA1 PXN [activation] TNNT1 BMPR1B [activation;inhibition] LMO7 GRB2 [activation] FASN AKT1 [activation] CAV1 PTCH1 [activation] EIF2S3 SUMO2 [activation] H2AFX STK11 [activation] CD244 LAT [activation] ACTB PPP2R2B [activation] OBSL1 NDC1 [activation] GNA13 S1PR4 [activation] MYC PDLIM4 [activation] FOSL2 EP300 [activation] PBX1 FOXC1 [activation] LRRK2 CDC42EP3 [activation] CAV1 RADIL [activation] FANCD2 CDK20 [activation] MAPT PHKG1 [activation] GTPBP2 E2F3 [activation;inhibition] ATXN10 PPP1R12A [activation] SIRT2 SARS [activation] CHEK2 RNF20 [activation] DCXR TRAF6 [activation] GPSM1 RALBP1 [inhibition] PCNA HLA-C [activation] MAGED2 IRS4 [activation] 页 299 共 454


2016/4/8 19:14

LSM14A TP53 [activation] CEP250 EIF4EBP3 [inhibition] GNB1 ERBB2 [activation] MAPK1 GAB2 [activation] HSP90AB1 KLHL34 [activation] BTLA PTPN11 [activation] KDM5A HIST3H3 [activation] DOCK8 MOB1A [activation] TRIP10 SRC [activation] MSANTD3 BMPR1A [activation;inhibition] MLH1 BACH1 [activation] HSD17B4 PLEK [activation] NXF1 DEPTOR [activation] RBPJ APP [inhibition] BRCA1 AURKA [activation] HSPA1A TTC1 [inhibition] WNK1 EIF3A [activation] RASA1 GAB1 [activation] RARS EGFR [activation] GLI3 YWHAE [activation] BANP EPHA10 [activation] DDX17 NCOA3 [activation] NR3C1 KIAA0408 [activation] RASSF4 HMGB1 [inhibition] HLA-A HYOU1 [activation] GCGR BMPR2 [activation] TRAFD1 TRAF6 [activation] ICAM1 RPL23A [activation] KCNJ12 PRKACA [activation] EFCAB4B ORAI1 [activation] SRPK1 RSRC2 [activation] TRIP6 BCAR1 [activation] DFFA CIDEB [activation] F12 UBE2D1 [activation] SETDB1 UBE2I [activation] TNF TBK1 [activation] VCAM1 EZR [activation] SOCS1 CSF1R [inhibition] EP300 HIST1H2AB [activation] ITPR1 BANK1 [inhibition] IRF7 TRMT61B [activation] ABI1 FGR [activation] TRAF6 CD40 [activation] BAAT CDKN2A [activation;inhibition] CDKN1A TP53 [activation] CHUK SRPK1 [activation] EGLN1 POLR2A [activation] TNFRSF14 RNF219 [activation] PBX1 HDAC1 [activation] SUMO1 ACOT8 [activation] MDM2 DSTN [activation] LTBP4 FRAT1 [inhibition] PIK3R1 MYLK [activation] GNAI2 CHRM1 [activation] CCDC88B PLEKHA5 [activation] HIST1H1C RELA [activation] PTPRC GRIN2B [activation] BMPR2 FHL2 [activation] MAPT HSPA8 [activation] SOX6 HDAC1 [activation] CSNK1A1 EIF2B5 [activation] CDC5L SMC2 [activation] PPP1CA PPP1R15B [activation;inhibition] KIAA1033 WASH1 [activation] ITGA9 FIGF [activation] RIT1 SMAD2 [activation] DUSP8 CDC25A [inhibition] TRPM7 MBP [activation] ABL1 SUV39H2 [activation] RPA3 EIF2S1 [activation] CDK2 OGT [activation] GDF9 TRIB3 [activation] TRAF6 HSPE1 [activation] MRPL43 ITGA4 [activation] INSIG1 UBC [activation] SRPK1 CHEK2 [activation] 页 300 共 454


2016/4/8 19:14

HNRNPH2 GRB2 [activation] CXCR4 DBN1 [activation] TRAF3 PPP3CA [activation] SMAD2 CORO2A [activation;inhibition] CALM1 MYF5 [activation] RPA3 HSPA8 [activation] SCRIB WWTR1 [activation] NDEL1 TACC3 [activation] SSR1 ILK [activation] EP300 EGR1 [activation] NCAM2 PRNP [activation] NXF1 RCN1 [activation] BARD1 FBXO5 [activation] KAT2B RB1 [activation] CKS1B CDK3 [activation] HSP90AB1 IGF1R [activation] STRADB TRAF6 [activation] PRNP MAG [activation] PRKDC E2F3 [activation] LRRC4 NTNG1 [activation] FDX1 NR4A2 [activation] HRAS GPSM2 [activation] PPP1R18 TRAF2 [activation] ARRB1 MAP2K4 [activation] KAT2B HIF1A [activation] CD22 LCP2 [activation] BCL2 HSPA1A [inhibition] RBL1 EPHB2 [activation] TNIK BCAP31 [activation] CDC5L GULP1 [activation] EIF4G1 PAK2 [activation] NFKB1 TWIST1 [activation] MAP3K8 TAB2 [activation] WASL PTK6 [activation] MAP1LC3B STK3 [activation] SMURF1 SENP8 [inhibition] CXCR1 ADRA1A [activation] WASF2 BTK [activation] STAT5A PRMT1 [activation] VAV3 BLNK [activation] SARS2 ICT1 [activation] ETFA PSEN1 [activation] CREBBP N4BP2 [activation] ARHGDIA JUP [activation] ARPC2 CTTN [activation] IL32 C1QB [activation] AKAP4 FSIP2 [inhibition] NARF LEF1 [activation] NOS1 ZDHHC23 [activation] LRRK2 SRPK1 [activation] IRF2 HMGN1 [activation] CCT8 NOTCH1 [activation] ACTG1 MAP3K7 [activation] ADORA2A ACTN3 [activation] RELA IRF5 [activation] TIAM2 DNM2 [activation] MAPT UBE2D2 [activation] HIST3H3 MCM2 [activation] SDF4 ANXA7 [activation] MAX MYCL [inhibition] PPP3CA NR3C1 [activation] TTK NXF1 [activation] BCL2L13 VAMP3 [activation] STAT3 MAP3K7 [activation] PKN1 CD44 [activation] HNRNPR SRPK3 [activation] KLK6 SERPINF2 [activation] PRKCQ IKBKG [activation] ARAP1 TAB1 [inhibition] PA2G4 HMGA2 [activation] SPP1 TMEM30A [activation] ERBB2IP MEF2A [activation] RAC2 HDAC10 [activation] MMP13 CCL7 [activation] ANAPC5 ANAPC15 [activation] PSENEN FTL [activation] 页 301 共 454


2016/4/8 19:14

SMAD5 SMAD2 [activation] NOTCH1 ARRB1 [activation] APP PTK6 [activation] RAE1 BUB1 [activation] SSH1 CFL2 [activation] SRPK1 ECM1 [activation] PRRC2A GRB2 [activation] MAP3K3 PRKACA [activation] POU1F1 JUN [activation] LCK FASLG [activation] CHD8 CTCF [activation] CAND1 EIF4EBP3 [inhibition] XIAP AKT1 [activation] FOS EGFR [activation] SLC25A6 RELA [activation] GOPC RHOQ [activation] UBA5 TARS [activation] TGFBR1 ARL8B [activation] EP400 ESR1 [activation] PWP1 SMURF1 [inhibition] PTPRK JUP [inhibition] BPTF DPY30 [activation] TRAF1 CD40 [activation] PRKAA1 RFX6 [activation] LATS1 CEP152 [inhibition] MRC2 AKT1 [activation] JAG1 CD46 [activation] ADAMTSL4 TSSK3 [activation] STIM1 SUMO1 [activation] VCL SUMO2 [activation] EIF4A3 POTEJ [activation] TSC1 CDK1 [activation;inhibition] CFTR TIAM1 [activation] ICAM1 NOS2 [activation] RAC1 PARD6G [activation] KMT2A SBF1 [activation] UGT1A1 UGT1A7 [activation] FZR1 CKAP2 [inhibition] PPIA ATF2 [activation] RAP1GDS1 KRAS [activation;inhibition] ESR1 CAV1 [activation] RELA TP53 [activation] PENK OPRM1 [activation] SPP1 ACP5 [activation] EP300 BUB1B [inhibition] GNAI2 CNR1 [activation] PIK3R1 AR [activation] PIK3R1 ADAM12 [activation] ACACA SIRT1 [activation;inhibition] RHOB DAAM1 [activation] CDK2 C12orf65 [activation] MCL1 TP53 [activation] TP53 MRPS27 [activation] EGFR EXOC8 [activation] NRXN3 NLGN1 [activation] CD22 IGHM [activation] WDR73 TNFRSF14 [activation] GRB2 UBR4 [activation] PALB2 BACH1 [activation] SHC1 PTPN6 [activation] GADD45G RBM48 [activation] APP ARHGEF5 [activation] DDIT3 PICALM [activation] MCM7 NFKBIA [activation] ARL2 VCAM1 [activation] NOX5 UBE2I [activation] LARS DDA1 [activation] SMAD6 SMURF1 [inhibition] YWHAZ MAP2K5 [activation] MLH1 PMS2 [activation] SNRPA1 CASP4 [activation] RASSF1 GABARAPL2 [inhibition] MLST8 DEPTOR [activation;inhibition] CCDC57 LINC00526 [activation] APP ASS1 [activation] BCL2L1 ZNF219 [activation] 页 302 共 454


2016/4/8 19:14

FLNA RALA [activation] CCNG1 PNMA1 [activation] MET DCN [activation] ZC3HAV1 AURKB [activation] SMURF1 PRPF31 [inhibition] ANAPC1 PAXIP1 [activation] BMX HSP90AA1 [activation] ITGA4 IQGAP1 [activation] PIKFYVE VAC14 [activation] CAV1 PTPRF [activation] CREBBP PAX5 [activation] EFNB2 PTPN13 [activation] SH3GL3 LRRK2 [activation] SRPK1 C16orf78 [activation] NUMB PRKCH [activation] UNC93B1 FASTKD5 [activation] TWF2 ERC1 [activation] E2F1 CSNK1A1 [activation] NCAM2 MYB [activation] ARF6 GLS [activation] MYC CDK6 [inhibition] AXIN1 PRMT1 [activation] FBXW11 ATF4 [activation] SRPK3 RSL1D1 [activation] ENDOV PRPSAP2 [activation] STK3 FAM9B [activation] NEK6 NCAPD2 [activation] PTPN1 PRKCG [activation] SYK CD3E [activation] PAXIP1 INTS7 [activation] RAP1A RASA3 [activation] HLX HDAC1 [activation] LATS1 STK11 [activation] SRSF3 EIF4A3 [activation] ELK1 EP300 [activation] UBL5 ITGA4 [activation] CCL5 APC [activation] EP300 PAK2 [activation] TFEB SRPK1 [activation] RAD50 BARD1 [activation] RANBP2 OBSL1 [activation] FGFR2 BEX2 [activation] RAC1 ARHGAP31 [activation] CSF2RA CSF2 [activation] HSD17B4 MAPK8 [activation] NFKBIA MTOR [activation] HIST1H3A IGSF8 [activation] SIGLEC14 TYROBP [activation] PTEN GFRA2 [activation] ARPC3 OTUD5 [activation] STARD9 CDK5RAP2 [activation] GNB1 GNG13 [activation] ITGA4 MYL12B [activation] CREBBP MYC [activation] RHOB ARHGEF1 [activation] MTMR10 SMAD5 [activation;inhibition] MKI67 FYN [activation] PIN1 DAB2 [activation] FOXO3 MAPK6 [activation;inhibition] EXPH5 APC [inhibition] ULK1 USP10 [inhibition] WASF1 IL8 [activation] E2F1 ASH2L [activation] CSNK1D MAPT [activation] PRMT3 EGFR [activation] CD84 PTPN11 [activation] TNIP2 APP [activation] ARPC5 NR3C1 [activation] TBX1 TERF2 [activation] GNB1 NOL11 [activation] MYC USP9X [activation] STX4 SNAP25 [activation] PES1 ESR2 [activation] PRR5L MAPKAP1 [activation] CSN2 AURKA [activation] MAP3K3 BIRC2 [activation;inhibition] 页 303 共 454


ARRB1 MDM2 STRA13 MDM2 BTF3L4 TXLNA PFN1 ITGA4 VAV1 SLA HSPA1L PCK1 APEH UBA5 ADAM10 EFNA2 PTEN CDC27 YWHAG LTB4R PUF60 ILK EPOR BTRC DNAJC5 PRKACA GLIPR2 CAV1 PRKCB BTK CRHR1 GNAI1 EGFR IRS4 C3 CFHR4 RAP1B PDHB GZMA HDC ITK SMAD4 THBS1 APP LTBR TNF CASP3 MAP3K14 VCAM1 GP1BB BLNK PPP2R2C GAPDH OSMR DDX5 SRPK1 FRS3 PTPN11 ERBB3 TNS3 CCND1 NXF1 NFKBIA SKP1 RAPGEF2 STOM SFRP4 AURKA ACKR2 APP ESRRA MAP2K5 RUNX1 TLE2 PPP6R2 AURKA MAPK3 STAB2 FYN FYB HSP90AB1 ADRBK1 MAPK3 ARRB2 AKT1 SRC LCP2 ACTB LYN ACTN1 NR1H3 PPP2R2A MLH1 ESR2 IL24 EDN3 KEL TFF1 AKT1 MTOR IKBKB RASA1 LCK HMGN1 PRKACG NFKBIA TUBB4A CD4 CD53 TIRAP EIF2AK2 PAK4 SFN YWHAZ BCAP31 APP IL18RAP SMAD3 DDX4 NSG2 APOC1 MYEF2 MAPK14 DVL2 SMAD3 CD81 GLP1R RAC1 BAIAP2 TRAF6 MAST2 MOS KIFC3 WNK1 FAM96B CDKN2A CDC7 RAB7A ATG5 TP53 MRPS9 EIF4A1 EIF4G3 GABARAPL2 EFCAB4B STIM1 JAM2 JAM3 USP28 TP53

2016/4/8 19:14

[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] NFKB1 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] TSR2 [activation] [activation] [activation] [activation] 页 304 共 454


2016/4/8 19:14

GDF2 ACVR2A [activation] ARAF RRAS [activation] CDC5L EIF4A3 [activation] SPATA5L1 NXF1 [activation] EZH2 POLA2 [activation] NSF DRD2 [activation] PRKAA1 KRT40 [inhibition] CBL CSF1R [activation] GDF6 SMAD5 [activation] GSN VASP [activation] UBASH3B SHC1 [activation] PPP2CA CFL1 [activation] TFRC RPA3 [activation] OSGIN1 ATM [activation] GAPDH BLK [activation] KRTAP19-7 CAMK2B [inhibition] OTX1 KCNK16 [activation] RPS6KA1 ACACA [activation;inhibition] GNAQ CRHR1 [activation] NDEL1 CDC42 [activation] IRF3 SMAD4 [inhibition] PIK3R1 MAP3K11 [activation] SH2B2 GRB2 [activation] DOCK10 RHOJ [activation] EFEMP2 LINGO1 [activation] SMAD3 GIT2 [inhibition] GSK3B MITF [activation] HSP90AB1 C20orf194 [activation] MAPK6 FBXL16 [activation;inhibition] C1R SERPING1 [inhibition] CASP3 HSPD1 [activation] SLC25A6 MAX [activation] PAEP A2M [inhibition] PPP2CA MDC1 [activation] BIRC5 CDK4 [activation] PIK3CA UBC [activation] CYTH3 IPCEF1 [activation] OSGEP CRIP2 [activation] NCOA2 OPN1LW [activation] PPP1CA WNK1 [activation] TMEM102 YWHAG [activation] IL15RA IL2RG [inhibition] PLXNA2 KIAA1199 [activation] RAD21 HNRNPH2 [activation] ESR1 SMARCB1 [activation] KMT2B ANXA7 [activation] TTLL3 DAPK1 [inhibition] STRADB XIAP [activation] RPS6KA1 PPM1G [activation] PGR TAF1B [activation] CREB1 SMARCA5 [activation] TIGAR APP [activation] XPO1 CHEK1 [activation] EIF4E EIF4G2 [inhibition] HIF1A EP300 [activation] SUMO1 PPARG [activation] SH2D3A ERBB2 [activation] TRAF2 AMOTL2 [activation] PRKCE SNCA [activation] FASLG PIN1 [inhibition] PRNP SCNM1 [activation] TP53 SMARCAL1 [activation] AURKB HIST3H3 [activation] SYK MYD88 [activation;inhibition] STAT1 FLT1 [activation] HSP90AB1 WASL [activation] SCAMP5 SNAP23 [activation] SPAG9 MAP2K4 [inhibition] ZAP70 SH3BP2 [activation] DDX50 ESR2 [activation] PRKRA RABEPK [activation] LCP2 FCGR1A [activation] IL18R1 IL1RAP [activation] TP53 CEBPZ [activation] AURKB CDC73 [activation] LCP2 SHB [activation] 页 305 共 454


2016/4/8 19:14

CCNK DVL3 [activation] WDR18 ESR1 [activation] CORT SSTR4 [activation] CCNA2 CDC6 [activation] MAP1LC3B TGM3 [activation] ICAM1 MSN [activation] EPHA7 ZNF267 [activation] RAG1 RUNX1 [activation] SRPK2 MRPS6 [activation] MAGED1 DAB1 [activation] TRAF3 TNFRSF1B [activation] KDM3A RPS6KA5 [activation] SMAD1 ECSIT [activation] MST4 PPP2R1A [inhibition] EIF3A EIF4A1 [activation] SYK FCRL3 [activation] HIST1H2BC ITGA4 [activation] HSPB1 NEK10 [activation] EGFR LINGO1 [activation] DDX21 HLA-B [activation] VCAM1 KPNB1 [activation] MAFK TP53 [activation] TNFRSF13B IRAK4 [activation] ROBO2 OLFM2 [activation] SCGB3A1 FGFR4 [activation] APH1A ATF4 [activation] GNB4 NUDC [activation] C17orf62 ETS1 [activation] YWHAZ GSK3B [activation] RFWD2 JUNB [activation] IL1B CASP4 [activation] CSF2RA PIK3R1 [activation] STK11 XPA [activation] ZFYVE1 BCL2L1 [activation] SUMO1 EIF2S3 [activation] RPA3 MYO1B [activation] SOX15 BHLHE40 [activation] RALGDS RIN1 [activation] EGLN2 FAM46A [activation] CD4 CD28 [activation] IL4 IL13RA2 [activation] GABARAPL1 IGKV1-5 [activation] CLEC7A TLR2 [activation] PIK3R1 PTPN6 [activation;inhibition] CEBPE RB1 [activation;inhibition] RAC1 NGEF [activation] EEF1D LRRK2 [activation] CEBPB HDAC9 [activation] IRAK1 CCDC8 [activation;inhibition] FST MEST [inhibition] HIST1H1B RPS6KA5 [activation] TOP2A MAPK1 [activation] LZTR1 SREBF2 [activation] TNFRSF11A TMPRSS15 [activation] CHRM1 ARRB1 [activation] PBX2 NUP62 [activation] PPARG NCOA1 [activation] CDKN1B YWHAB [inhibition] ABI2 MRFAP1L1 [activation] ANKFY1 RHOD [activation] ENOX1 NIF3L1 [activation] CDKN1A WDR73 [activation;inhibition] MYC MAP3K7 [activation] TRIP10 CREBBP [activation] SMG1 PRKCI [activation] ARPC2 UBE2Q2 [activation] MDM2 MYL6 [activation] SRC PPP2R4 [activation] LRP1 MMP16 [activation] MAPK11 ARHGAP12 [activation] CASP6 RB1 [activation] PRKCQ GLRX3 [activation] GABARAP PPA1 [activation] MYC PRR11 [activation] TP53 MNDA [activation] NXF1 CSNK2B [activation] 页 306 共 454


2016/4/8 19:14

PFAS SGK1 [activation] GPC4 ACP5 [activation] PAK4 APP [activation] ANTXR2 SMAD2 [activation] CREB1 SRF [activation] STK3 EIF4EBP1 [activation] RAN XPO4 [activation] ICK NUP188 [activation] IGJ STK4 [activation] EZH2 AKT1 [activation] SPP1 CYB5R3 [activation] RAN PTBP3 [activation] PPP1R14A CSNK1E [activation] MTNR1B GNAI1 [activation] MAPRE2 CDK2 [activation] KIR2DL2 HLA-C [activation] RAB5A PIK3CB [activation] MAPK1 GATA1 [activation] SLC9A3R2 PODXL [activation] TJP1 ACTB [activation] CAMK2G TH [activation] RABL5 MAGEB2 [activation] APITD1 RPA1 [activation] ATXN10 GLS [activation] BMP6 CHRDL2 [activation] CCDC170 CCNH [activation] ECT2 MAPK1 [activation] CREB1 SREBF2 [activation] LRRK2 SLC25A11 [activation] TTR ATF4 [activation] WDR73 ANXA7 [activation] MYL12A CD4 [activation] ANAPC7 E2F1 [activation] MCM7 RAD21 [activation] PIK3CA SMAD3 [activation] HIST1H1B PRKCD [activation] TP53 PRMT3 [activation] STAT3 SUPT20H [activation] PPFIBP1 YWHAB [activation] SRC ASAP2 [activation] STK3 PLK1 [activation] GRK4 FSHR [activation] EIF4EBP1 CHTF8 [inhibition] SHC1 CEACAM1 [activation] MED1 HNF4A [activation] SFN PKP3 [activation] TRAF6 CAPZA1 [activation] CCDC85A STMN2 [inhibition] STAT3 CAPNS1 [activation] GNGT2 GNB2 [activation] TNIP3 TBK1 [inhibition] RALGDS KRAS [activation] PAXIP1 NME4 [activation] AURKA NEDD9 [activation] TBRG4 MAL2 [activation] MET SH2D3C [activation] HSPH1 BUB1B [inhibition] TWIST1 NEIL3 [activation] MCM3 MCM2 [activation] LAT VAV1 [activation] ACTB TAGLN2 [activation] PPFIA1 PPP2CA [inhibition] ENO3 TTN [activation] USHBP1 CCDC146 [activation] SPP1 PLD3 [activation] BCR MLLT4 [activation] HIST1H1C CTNNB1 [activation] IL2 SHC1 [activation] SRPK2 CDK13 [activation] PCED1A TNFRSF14 [activation] LRRK2 YWHAH [activation] BTN3A3 ARL8B [activation] NUP98 APC [activation] MAP1LC3B ARFGAP1 [activation] FLNC MLH1 [activation] MYC PRKDC [activation] 页 307 共 454


2016/4/8 19:14

ZKSCAN8 SRPK1 [activation] CNTNAP2 MACF1 [activation] MRPL4 ICT1 [activation] DAB1 DAZAP2 [activation] UBC HSF1 [activation] PFKFB2 YWHAB [activation] BMP7 UBC [activation] PRKDC ATM [activation] CCND3 NPDC1 [inhibition] HSP90AA1 FES [activation] FLT3 SYK [activation] CTNNB1 NUP153 [activation] NUP50 LRRK2 [activation] NOS3 H3F3A [activation] ACVR2A GDF9 [activation] SIRT1 CACNA1C [activation] ATPIF1 BLK [activation] E2F1 ATR [activation] DCC APPL1 [activation] SFN RALGPS2 [activation] MAP3K3 NFKBIA [activation] GRB2 DNAJA3 [activation] C1orf109 CCDC36 [activation] SOCS3 BIK [activation;inhibition] IL9R JAK1 [activation] RANBP2 TOP2A [activation] PYCARD NLRP2 [inhibition] PFKFB3 ASB12 [activation] GRB2 ELK1 [activation] CSNK1G2 NCK1 [activation] SRPK2 HOMER3 [activation] HHEX TLE1 [activation] NGB GNAI1 [activation] NBN RECQL5 [activation] IL1RAP SMAD2 [inhibition] MEMO1 ERBB2 [activation] PROSER2 ACTB [activation] VAPB PRKACA [activation] WASF3 PIK3R2 [activation] PML CSNK2A3 [inhibition] PTBP3 OGT [activation] RFC1 NOTCH1 [activation] FBXL3 BTG1 [inhibition] HCK ADAM22 [activation] CD4 NCL [activation] HIST1H4A PYHIN1 [activation;inhibition] USP20 PLEKHA7 [activation] MDM2 CHRM3 [activation] NR3C1 PIAS2 [activation] TBC1D3B HSPB1 [inhibition] TIAM1 CSNK1A1 [activation] TLE1 PROP1 [activation] PHGDH VCAM1 [activation] DDX24 EP300 [activation] SIX2 APP [activation] SLC25A6 LRRK2 [activation] LEPR RNF41 [activation] HSD17B8 RAD21 [activation] ANAPC1 SMARCAD1 [activation] SAMD9L EEA1 [activation] MLH1 PARP12 [activation] DNPEP RBL1 [inhibition] CTDSP2 AR [activation] SHANK3 ARHGEF7 [activation] ARGLU1 SRPK2 [activation] FANCB FAAP100 [activation] AKT2 SNAI1 [activation;inhibition] NTRK1 NGFR [activation] FSHR FOXO1 [activation] SASH1 SUV39H2 [activation] OSBPL10 MMP2 [inhibition] STK11 GNPDA1 [activation] APP GOSR2 [activation] CFL1 CD81 [activation] MDM2 IDH3A [activation] YWHAQ WNK4 [activation] 页 308 共 454


2016/4/8 19:14

KPNB1 BARD1 [activation] AVIL CRK [activation] BLNK DOK3 [activation] C8orf33 FYN [activation] IL32 PRKCD [activation] EGFR CAMLG [activation] FASN MAP3K3 [activation] GRB2 ID4 [activation] LIMK1 YWHAZ [activation;inhibition] SPECC1 GRB2 [activation] PSTPIP1 WASF1 [inhibition] TIMP2 SNCG [activation] FGB CDKN1A [activation] PTPRF SKIL [inhibition] ARRB1 PPM1B [activation] RPA2 APITD1 [activation] PRKCD NUMB [activation] EPHA2 SLA [activation] EIF1B EIF1AX [activation] DVL3 VANGL1 [activation] EIF2AK2 TOLLIP [activation] ABL1 DOK1 [activation] GNAS LHB [activation] GRK6 SNCG [inhibition] GABARAPL1 JUP [activation] HMOX1 BLVRB [activation] HSP90AA1 H2AFX [activation] ABL1 DDX5 [activation] CSNK1E PRMT5 [activation] TNFRSF8 ALK [activation] ZFYVE9 PPP2R1A [activation] MTIF2 ALK [activation] HEMGN KRAS [activation] TBX5 GATA4 [activation] PPP1CC MAX [inhibition] PER3 ATM [activation] UGT1A6 UGT1A1 [activation] HNRNPA0 MYC [activation] BMP3 COL4A1 [activation] PTEN DBF4B [activation] GJB2 CAV1 [activation] PPP1R14B ROCK2 [activation] INADL PAX6 [activation] YWHAQ MFF [activation] DAPK2 APP [activation] KATNB1 NDEL1 [activation] DAPK2 FAM9B [activation] NXF1 TXLNA [activation] PPP2R1A EIF1B [inhibition] PRR5 RICTOR [activation] PIK3CG BECN1 [activation] MAPK1 DUSP7 [inhibition] ACVR1 ACVR1B [activation] P4HB F3 [activation] RAB5A ZFYVE20 [activation] RB1 CASP9 [activation;inhibition] TRAIP CYLD [inhibition] HSPA5 RIPK1 [activation] RAC1 PRMT6 [activation] YWHAZ HIST1H1C [activation] LIMK2 CDC42BPA [activation] HSPB2 CRYAA [activation] HSPA8 RIPK1 [activation] ACTB ABRA [activation] TNC CNTN1 [activation] NXF1 ZBED8 [activation] TRADD HSP90AB1 [activation] DUSP3 SYK [inhibition] DLX4 FYN [activation] OLIG2 CUL3 [activation] ABL1 PRKCZ [activation] NCK1 EIF2B2 [activation] PRKCZ NUMB [activation] NUMA1 NXF1 [activation] MYC SARS [activation] IL6 ZBTB16 [activation;inhibition] 页 309 共 454


2016/4/8 19:14

IRS4 YWHAG [activation] CXCR2 ADRA1A [activation] CDC20 RASSF1 [inhibition] KIFC3 ABI2 [activation] SEMA4D PTPRC [activation] CDK18 CCNK [activation] TERF1 TRIOBP [activation] STX19 STXBP1 [activation] FMNL1 GAS7 [activation] POU2F1 STAT5B [activation] TRAF2 FBXO28 [activation] TRIB3 LTBP4 [inhibition] RPA1 RPRD1B [activation] REN KCTD15 [activation] ACVR1B IGSF1 [activation] PTPN12 CDH2 [activation] SERINC3 VDAC3 [inhibition] AR SHE [activation] MCM7 CCL2 [activation] CTNNB1 PARD3 [activation] ATAD3B MYC [activation] POTEE RELA [activation] EYA1 FBXW7 [activation] NFKB2 NFKBIA [activation] RAP2B RUNDC3A [activation] DLX4 PLCG1 [activation] SRC DLGAP2 [activation] LCAT APOE [activation] TRAF6 RANBP1 [activation] THAP8 TP53 [activation] RANBP9 APC [activation] ZAP70 PRLR [activation;inhibition] GH1 JUP [inhibition] ATG101 ULK1 [inhibition] VCAM1 HIST1H4A [activation] MAPK14 CBL [activation] APOH CLEC4G [activation] EZH2 RARA [activation] FASLG NCF1 [activation] SMAD7 AXIN1 [activation] WNK1 YWHAQ [activation] OBSL1 MACF1 [activation] ERBB2 IGF1R [activation] PPP2CB STK11 [activation] PACSIN3 LGALS13 [activation] TRAF6 SIGIRR [activation] PROC SERPINB6 [inhibition] MAP1LC3B CASP8 [activation] DNM1L UBE2H [activation] UPF2 MYB [activation] GARS YWHAZ [activation] C1orf63 SRPK1 [activation] FTSJ3 SRPK3 [activation] WASF1 PFN2 [activation] BMX ITK [activation] CYB5R2 CDC23 [activation] UBXN11 TRAF2 [activation] SMURF2 RASD2 [activation] SLK GABARAP [activation] PKN1 PLD1 [activation] CCDC120 CEP170P1 [activation] BCL2L1 BECN1 [activation] CHEK1 SMURF1 [inhibition] PLG F2R [activation] NFATC2 IQGAP1 [activation] TBC1D4 AURKB [activation] MKRN1 TP53 [activation] CDC5L NBN [activation] C16orf45 RAPGEF4 [activation;inhibition] PRKAG1 PRKAA1 [inhibition] MYC MATN4 [activation] ITGAV F2R [activation] PPP1CC PRR16 [inhibition] SKAP1 PTPRC [activation] ATG5 HTT [activation] MYO18A NXF1 [activation] 页 310 共 454


2016/4/8 19:14

CHN2 TGFBR1 [activation] SH3KBP1 SRGAP1 [activation] ITGA1 ITGB1 [activation] TFF1 XRCC3 [activation] HRG FCGR1A [activation] TMEM150A NOTCH2NL [activation] PCK1 HLA-C [activation] YWHAE DDX21 [activation] MAGEH1 NGFR [activation;inhibition] DYRK1A KIAA0232 [activation] PTPN11 SOCS1 [inhibition] MAPKAPK3 BMI1 [activation] LGALS4 RRAS2 [activation] VTI1B STX4 [activation] CD4 CD44 [activation] LIPC LRP1 [activation] TNFSF13B TNFSF12 [activation] PRKCI APP [activation] STK4 MAP1S [activation] BTK CAV1 [activation] ETV4 SRF [activation] PLCG1 SOS1 [activation] CDK4 UBTF [activation] YAP1 CPVL [activation] EGFR SOCS3 [activation] ACTR2 EIF1B [activation] HTR2A MAP1A [activation] POLD3 APP [activation] UBTD1 MRFAP1L1 [activation] NCK1 ERBB4 [activation] SLC25A6 TMEM62 [activation] TNKS APC [activation] UBB MAPT [activation] E2F1 MNAT1 [activation] DDX17 DDX5 [activation] ERBB2 HLA-A [activation] NRXN3 MLLT4 [activation] HTR1F CAV1 [activation] APCS GRB2 [activation] YWHAB CAMKK1 [activation] TMBIM6 VTI1A [activation] NFKB1 NOTCH1 [activation] OS9 SREBF2 [activation] ANXA1 KLHL23 [activation] POU1F1 MED1 [activation] MCL1 NXF1 [activation] LILRB1 HLA-F [activation] APC RP1 [inhibition] RAP1B KMT2B [activation] LY6D PKIB [inhibition] NXF1 ATP6AP2 [activation] EGR2 UBE2I [activation] CDC5L PRKDC [activation] ARRB2 PFKFB3 [activation] STK4 TP53 [activation] IFI16 NOTCH1 [activation] WNK1 BAG3 [activation] PTPN6 PTK2B [activation] NXF1 HNRNPAB [activation] MYOD1 ESR2 [activation] TCAP ENO3 [inhibition] CTNNA1 CDC5L [activation] VAMP3 CCDC8 [activation] YWHAB CYLD [inhibition] RIPK2 GXYLT1 [activation] CALCA ATP2B4 [activation] HBG2 ITGA4 [activation] STIP1 MOS [activation] WHSC1L1 ATM [activation] TSSC1 DEGS1 [activation] AURKA PPP6C [activation] SEC16A LRRK2 [activation] FTO FTSJ1 [activation] CDK1 CDKN3 [activation] POLE4 POLE2 [activation] HSPA1A TP53 [activation] 页 311 共 454


2016/4/8 19:14

CUL1 CCND1 [inhibition] EIF2B4 EPB41L3 [activation] TNF POU2F1 [activation] CLSTN1 PRNP [activation] CUX1 HMGB1 [activation] NRIP1 PPARG [activation] RAD50 RRM2B [activation] SRPK1 ERBB2 [activation] FANCG FANCA [activation] SRPK2 CHD2 [activation] H3F3A ASB2 [activation] MPP5 YAP1 [inhibition] PELI3 IRAK4 [activation;inhibition] PITX2 MEF2A [activation] ESR1 C20orf197 [activation] PXN PTPRT [activation] MAP3K7 STRADB [activation] HSP90AA1 IKBKB [activation] TERT SRC [activation] PPP2CA ADCY8 [inhibition] NFKBIA FBXW11 [inhibition] GSK3B IVNS1ABP [inhibition] PRKACA AKAP14 [activation] VTI1A STX7 [activation] ADRA2A GNB1 [activation] IGFBP5 VTN [inhibition] CYCS POR [activation] SCN8A MAPK14 [activation] PCSK1 PCSK1N [activation;inhibition] EGR1 VDR [activation] ACKR4 CCL19 [activation] CTBP1 CREBBP [activation] TYK2 NXF1 [activation] FYN WIPF1 [activation] BUB3 EXOC3 [inhibition] CDK7 ESR1 [activation] IL23A IL12B [activation] PIK3R1 DLX4 [activation] TGFB1I1 ITGA4 [activation] TIRAP NF1 [activation] MAPK3 PPP1CA [activation;inhibition] CD81 MCM5 [activation] RAB11B RPA3 [activation] CD19 CR2 [activation] GRB2 RPS25 [activation] CHUK SHARPIN [activation] ADAM10 SH3D19 [activation] ZFYVE20 RAB5C [activation] APH1A PSENEN [activation] LCK IFNAR1 [activation] ESR2 MYL6 [activation] BOD1L1 VAV2 [activation] HSP90AB1 LIMK2 [activation] LGR4 PRKDC [activation] NXF1 TP53BP1 [activation] NXF1 C19orf10 [activation] PLIN2 ARF1 [activation] MYO1C BAZ1B [activation] MYC ADIPOR1 [activation] CACNB4 SYT1 [activation] KPNB1 RAC1 [activation] NUP62 CCDC121 [activation] HSPA5 TRAF6 [activation] HRG C1QA [activation] SEH1L RPA1 [activation] TNFRSF14 NRIP1 [activation] DRD2 KCNJ9 [activation] GRID2 GRIA2 [activation] NSUN2 EGFR [activation] BARD1 POLR2A [activation] TNFRSF25 TRADD [activation] VCAM1 MIF [activation] ATF2 HSP90AA1 [activation] MAPK4 CALML3 [activation;inhibition] FGF5 EGF [activation] ACAP1 SRC [activation] 页 312 共 454


2016/4/8 19:14

DLGAP1 SRC [activation] PIAS2 DDX39B [activation] MOB1A DOCK6 [activation] GRB2 FYB [activation] PCDH18 ATG5 [activation] CAV1 EDNRB [activation] MYO1C EGFR [activation] MAP2K1 MLH3 [activation] MDC1 WHSC1 [activation] CRTC2 CREBBP [activation] CD82 LRP1 [activation] CDK4 CDK5R1 [activation] EZR SGK1 [activation] GNAI2 TRIP6 [activation] CCNB2 TGFBR2 [activation] WFDC5 STAG1 [inhibition] YWHAQ DAB2IP [inhibition] YWHAG NUMBL [inhibition] NFKB2 PPP2R1A [inhibition] PRKAG2 PRKAA2 [inhibition] GRB2 PTPRN2 [activation] KAT2B GLI1 [activation] AGR3 NUP62 [activation] MCM7 MCM8 [activation] YWHAH PAK4 [activation] GABRR2 GABRR1 [activation] RFC5 GABARAP [activation] PBK TP53 [activation] ITCH TP53 [activation] KLHL38 USHBP1 [activation] LPHN1 APC [activation] EP300 NCOA1 [activation] MOS CCDC102B [activation] TXNL4A IL31RA [activation] RAB5A NME2 [activation] CDK5RAP3 CDKN2A [activation;inhibition] GDF9 BMPR1B [activation] LOX MYC [activation] MYO1C PTP4A3 [activation] YWHAZ CBLL1 [activation] CLEC4G GEM [activation] FAS MET [inhibition] NAB2 MAPK3 [activation] ATG5 UCHL1 [activation] PREX1 RICTOR [activation] SHB GRAP2 [activation] ABL1 RASA1 [activation] EIF4A1 MAPK6 [activation] CSK RGS16 [activation;inhibition] GRB2 POLR2A [activation] RNF19A UBE2E2 [activation] OBSL1 CTTN [inhibition] EPHB6 GRB2 [activation] CYCS VCAM1 [activation] YWHAZ EIF2S1 [activation] HNRNPA0 MTNR1B [activation] FGA HRG [activation] MDM2 GNB2 [activation] APP ATF4 [activation] DSTN ISG15 [activation;inhibition] ITGB1 ADAM17 [activation] CCDC85B SIX1 [activation] TULP3 KLF10 [activation] PXN CEACAM1 [activation] MCF2L RAC1 [activation] HSPB1 MTIF2 [activation] HLA-B PDCD5 [activation] CMPK1 ATG5 [activation] CD48 CD2 [activation] HLA-B PMPCB [activation] SMURF1 LONRF3 [inhibition] PRPF38B CTNNB1 [inhibition] BLK CCDC33 [activation] BAX SFN [activation] ETS1 PRKDC [activation] TP53 FBXO42 [activation] 页 313 共 454


2016/4/8 19:14

SMURF1 ACTB [activation] FAM175B GRB2 [activation] TRAIP TBK1 [activation] BCAP31 VAMP1 [activation] HIST3H3 TBP [activation] LTBP3 HBEGF [activation] NOTCH1 VAV1 [activation] EIF2AK4 TGFBR1 [inhibition] NOTCH1 TRIM28 [activation] SUV420H2 TUB [activation] YWHAB VCAM1 [activation] FKBPL NR1H3 [activation] TNFRSF1A ARFGEF2 [activation] EIF3F CDK11B [activation] LIMS1 EHMT2 [activation] NGFRAP1 SMAD2 [activation] SLC25A6 CUTC [activation] DNAL4 SCTR [activation] CALM1 GRM3 [activation] CASP7 XIAP [activation] APH1A NXF1 [activation] F2 THBS1 [activation] ESR2 CTNNA2 [activation] RALGAPB SRC [activation] CSNK1A1 CSNK1D [activation] EIF2S3L CDC5L [activation] FES HSPA4 [activation] POM121C APC [inhibition] CDC25B YWHAH [activation] UFM1 DIABLO [activation] BCL2L1 PLD3 [activation] NXN PPP2CA [activation] ARF6 EPPK1 [activation] TRAF6 DIABLO [activation] FOXM1 RB1 [activation;inhibition] SYK SH2D2A [activation] TXNDC5 APP [activation] PTPRB MET [activation;inhibition] CDK2 CNKSR2 [activation] STMN2 NGFR [activation] ERCC2 EGFR [activation] H2AFX POLR2A [activation] PARP2 CHRDL1 [activation] CDX2 HNF1A [activation] CD300E TYROBP [activation] MAPK3 PTPRJ [activation] PIAS1 TP53 [activation] CASP12 XIAP [inhibition] CTNNB1 PECAM1 [activation] VCAM1 HNRNPA0 [activation] MAP4K4 PPP1CA [activation] SYN1 PIK3R1 [activation] A1BG CDKN1A [activation;inhibition] CREBBP JUN [activation] HSPA5 APC [inhibition] RICTOR YWHAE [activation] ELAVL1 CRKL [activation] NUP214 G3BP1 [activation] MAPK10 PKMYT1 [inhibition] MITF RPS6KA1 [activation] STK4 MAP2K4 [activation] NOD1 CARD6 [activation] ITGA2B F2 [activation] WRAP73 OGT [activation] ICT1 ERLIN2 [activation] SMAD9 SMAD2 [activation] CASP8 SERPINB5 [inhibition] GRB10 GHR [activation] B2M A2M [inhibition] MYD88 MAL [activation] TNFRSF14 CHD3 [activation] PTPN14 PTEN [activation] MYC SLIT2 [activation] CDH2 FBXO45 [activation] TWIST1 ETS2 [activation] MYO1C SLX4 [activation] 页 314 共 454


2016/4/8 19:14

ANXA1 TLE3 [activation] MFAP1 HSPB1 [activation] SYK TLR9 [activation] TMPRSS15 PYCARD [inhibition] ZNF226 ATF4 [activation] EIF4E IRS1 [inhibition] CDK5 MAST1 [activation] PTPN11 PRKCA [activation] WHSC1L1 CHEK2 [activation] MARK2 PRKAA1 [inhibition] ERCC1 FANCG [activation] PLCG1 RRAS [activation] RPA2 ATR [activation] WRAP73 MYO1C [activation] HDHD2 EPHB6 [activation] FZD5 RGS2 [activation] DNAJB2 FBXO25 [inhibition] KIF26B CDK6 [inhibition] HSPB1 C6orf211 [activation] ESR1 MRPS27 [activation] HSPA1L METTL22 [activation] RHOA PDE6D [activation] RELA EPRS [activation] SUMO1 ATF2 [activation] MMP14 CAV1 [activation] CREBBP MSX1 [activation] MYO1C TP53 [activation] GABARAP YWHAE [activation] TLR2 BGN [activation] RECQL5 NCL [activation] TNK2 PDGFRB [activation] RIMBP3 FANCL [activation] ELAVL1 RALA [activation] PTEN CHGB [activation] NCL PAX8 [activation] HSPB1 TXNL1 [activation] FGFR2 STAT5A [activation] C1orf51 CLOCK [activation;inhibition] MAPK15 WDR81 [activation;inhibition] MAPT PIN1P1 [activation] SRC RPS6KB1 [activation] BMP2 TGFB2 [activation] TP53 S100A6 [activation] PPP2CA ITGA4 [activation] RPS6KA5 HIST3H2A [activation] YWHAZ HSPB1 [activation] PRKACB NGFR [activation] IRF2 APP [activation] RIPK2 TLR4 [activation] PAK2 MAPK3 [activation] SERBP1 FOS [activation] CGB CGA [activation] GNAI3 NXF1 [activation] MAST2 SH3GL2 [activation] SGK223 YWHAE [activation] CDC23 COIL [activation] PRKCD ACTA2 [activation] PCSK1 PTK2 [activation;inhibition] PTPN11 ANXA1 [activation] PTGES3 NOD1 [activation] NUP214 NUPL2 [activation] CRK PTPN11 [activation] MAPK14 SUMO2 [activation] CAV1 BSG [activation] CCR5 ADRBK2 [activation] MAPK8 CEBPA [activation] PHGDH ESR1 [activation] GRB2 SEMA7A [activation] MAPT TUBB3 [activation] MYO1B ESR1 [activation] DIAPH1 RAC1 [activation] PRKAA1 L3MBTL3 [inhibition] ESRRG NRIP1 [activation] WAS ROBO4 [activation] CAMK4 NOS1 [activation] ANKRD12 CDK6 [inhibition] 页 315 共 454


2016/4/8 19:14

TNFSF14 TRAF2 [activation] MAGI3 FZD4 [activation] OBFC1 POT1 [activation] ADRA2C GNAO1 [activation] MAPK14 MBP [activation] SMYD2 EPB41L3 [activation] GRB2 KHSRP [activation] XXYLT1 NXF1 [activation] SMURF1 CXXC1 [inhibition] CASP3 SOCS5 [inhibition] ITPR3 ITPR1 [inhibition] E2F4 NXF1 [activation] BECN1 F7 [activation] CHEK1 SMAD4 [activation;inhibition] MAPK15 CACNA1H [activation;inhibition] PDGFRB GRB14 [activation] ETS1 AARS [activation] STAT3 TRAF6 [activation] APP JUN [activation] CAV1 ITPR3 [activation] SOS1 SH3KBP1 [activation] SMAD3 CDK11A [activation] ORC5 CDC7 [activation] YAP1 ATPIF1 [inhibition] ITGB2 ABL1 [activation] DDX21 ITGA4 [activation] ABL1 TERF1 [activation] NXF1 CYB5B [activation] RABEP1 JUN [activation] TNC PTPRB [activation] AKT1 PPM1A [activation] PRTN3 TNF [activation] DNM2 KPNB1 [activation] CCND3 CASP2 [activation] TRAF6 NGFR [activation] YY1 RAF1 [activation] NOTCH1 LCK [activation] NRIP1 RARA [activation] AHCYL1 SRPK2 [activation] CCDC8 STAT1 [activation] BAX BAK1 [activation;inhibition] CHEK1 BLM [activation] CALM1 TNIK [activation] RXRG NR1H3 [activation] PGK1 FOXO3 [inhibition] MYL12A HSPB1 [activation] PPP3R1 PPP3CA [activation] NR4A1 ESF1 [inhibition] SMAD9 ARHGAP9 [activation] CDKN2A BCL2L1 [activation] CDC16 ANAPC11 [activation] YWHAB DENND4C [activation] GIT2 GIT1 [activation] HNRNPA0 CSF2 [activation] PPP1R12A RPA1 [activation] SIGLEC6 FHL2 [activation] CTNNB1 AJAP1 [activation] NCR3 CD59 [activation] BCL2L11 ATP6V1G1 [activation] CDC42 PTBP3 [activation] GRB2 NR1H4 [activation] IFNG PDIA3 [inhibition] NOS3 MPRIP [activation] RASA1 KDR [activation] RXRA MECR [inhibition] SYK ERBB2 [activation] PRKCB MKI67 [activation] ATF3 SMAD2 [activation] GFPT1 MAPK8 [activation] GSKIP SMYD2 [activation] PRMT5 E2F1 [activation] GJD3 TJP1 [activation] BCL2L1 PGAM5 [activation] TNF ELAVL1 [activation] GABARAPL2 HNRNPL [activation] ATF1 PRKACA [activation] 页 316 共 454


2016/4/8 19:14

TRIM42 GLI1 [inhibition] SMAD2 CALM1 [activation] COL4A1 PDGFA [activation] SUV420H2 RB1 [activation] CDC42 RHOJ [activation] AHSG RRAS2 [inhibition] TLR5 SIGIRR [activation] NCK1 SOS1 [activation] EP300 ING1 [activation] ACTR2 GRB2 [activation] CAMK2A EGFR [activation] CDC42SE1 NXF1 [activation] CAV1 PPARG [activation] GRB2 RPS6KA1 [activation] RAB8A STK4 [activation] SRSF5 RPS6KA1 [activation] BAG2 TAB1 [inhibition] WNK1 SYNPO [activation] YY2 TWIST1 [activation] CRK WASF1 [activation] MED1 TP53 [activation] MIF MPG [activation] SGSM3 NXF1 [activation] FANCA FANCF [activation] RNF32 APOE [activation] C2orf44 PLK1 [activation;inhibition] ACTR3 ESR2 [activation] PTPRU IRS1 [activation;inhibition] ESR1 CTNNB1 [activation] CNN1 ADRB2 [activation] SRSF4 TICAM1 [activation] STAT3 ZFPM2 [activation] TLN1 PXN [activation] ANGPTL5 LILRB2 [activation] HLA-B DDT [activation] YWHAQ SMURF1 [inhibition] HLA-B VMA21 [activation] PTPRC UBC [activation] SNW1 MAP2K3 [activation] HSP90AB1 PRKDC [activation] CDH15 ARVCF [activation] CTNNB1 TOP2A [activation] WASF2 APBB1 [activation] KLF2 KAT2B [activation] CMTM5 DDA1 [activation] ATF5 CD34 [activation] ALPP LATS1 [inhibition] PRR20C SELV [activation;inhibition] STRADB GRB2 [activation] SMARCA5 SUMO1 [activation] NUDC PAK2 [activation] PRKCE GNB2L1 [activation] CHN1 RPS3A [activation] GABRG2 GABARAP [activation] DDX21 CDC42BPB [activation] HCLS1 GRB2 [activation] DCSTAMP CREB3 [activation] SMURF1 RTKN [inhibition] SOX2 CDC26 [activation] NUP93 WHSC1 [activation] FAN1 YWHAZ [activation] PLCG1 PRKD1 [activation] EHMT1 SUV39H1 [activation] HIST1H4A MAP3K3 [activation;inhibition] ADAM10 TSPAN15 [activation] MET CNR1 [activation] APP CACNG2 [activation] TRAF6 DNAJA1 [inhibition] SELPLG TPST1 [activation] PDGFRA SRPK1 [activation] TNNT1 OSM [activation] MYC NLRX1 [inhibition] RAN ASB2 [activation] PDLIM7 PRKCZ [activation] SRSF6 VCAM1 [activation] RAD50 RBBP8 [activation] 页 317 共 454


2016/4/8 19:14

ZMAT2 ETS1 [activation] APP RAB10 [activation] KSR1 HSP90AB1 [activation] UBE2N RHNO1 [activation] CCL8 ACKR2 [activation] ATF2 TACSTD2 [activation] RPS6KA5 ERH [activation] MLH1 FRAT2 [activation] IL3RA CDC25A [activation] MRPS27 SMURF1 [inhibition] VCAM1 ABCE1 [activation] IL6ST TYK2 [activation] NTRK3 NGFR [activation] WNK1 CENPJ [activation] VCAM1 MCM6 [activation] RELA ANXA1 [activation] ABL2 AR [activation] RAF1 MST4 [activation] ADAM10 PHB [activation] TNFRSF10C FAM101B [activation] MYC HIST1H2AB [activation] BLNK KIT [activation] GATA1 CASP3 [activation] STAT3 OGDHL [activation] VCAM1 ACTB [activation] TGFBR1 SKIL [activation] ATF1 CAMK2G [activation] ICT1 MRPS5 [activation] TRAF1 SLC25A6 [activation] CBL PTEN [activation;inhibition] CBL PRKCA [activation] MATK PTK2B [activation] MRPL38 TP53 [activation] FAM171A1 ETS1 [activation] GLP2R GCG [activation] PRKACB AKAP1 [activation] STK4 ACTBL2 [activation] SORL1 AURKA [activation] PFDN1 DEFA1 [inhibition] BPGM AKT1 [activation;inhibition] NUTF2 KPNB1 [activation] CDK5 HSP90AB1 [activation] EHMT2 NXF1 [activation] CUL1 FBXL3 [inhibition] NUDC KLHL34 [activation] FLI1 KAT2B [activation] RAD54B BAAT [activation] PRKACA SLC9A3R2 [activation] BRCA2 AURKB [activation] NXF1 ERBB2 [activation] GHR PTPN13 [activation] PSKH2 HSP90AA1 [activation] NOS2 HSPH1 [activation] BRD4 CLDN1 [activation] INADL F2RL2 [activation] RAF1 BIRC2 [activation;inhibition] SHC1 HSPA5 [activation] NUP214 SUMO3 [activation] ATF7 BCL6 [activation] PRNP HSPD1 [activation] MARK3 SOGA2 [activation] EPHB6 SMAD2 [activation] CBL SORBS1 [activation] SMAP1 PHLDA3 [activation] NCOA3 SMAD3 [activation] PLEK PF4 [activation] C19orf10 ATF2 [activation] LARP1 YWHAZ [activation] HBS1L SRPK2 [activation] ABI1 PAK2 [activation] LRRC4C NTNG2 [activation] CDK6 AR [activation] ACTA1 YWHAZ [activation] PPARG ESR2 [activation] LIMK1 CFL1 [activation;inhibition] NFKB1 YY1 [activation] 页 318 共 454


2016/4/8 19:14

ACTG1 IKBKG [activation] NUDCD3 KLHL38 [activation] MFNG DLL1 [activation] RPA1 CHD1L [activation] SRF RXRA [inhibition] QTRTD1 IGHG1 [activation] CHEK2 TLR3 [activation] RRAGC WNT2 [activation] ATG5 PCMT1 [activation] CDKL1 TGFBR1 [activation] ADRBK1 NFKBIA [activation] TP53 NCL [activation] SPATA2 PTPN6 [activation;inhibition] MERTK BMPR2 [activation] TYK2 UBE2F [activation] MYOM1 DNAJB6 [inhibition] MAD2L1 HSF1 [activation] ATR SMC1A [activation] EHMT2 ABHD17A [activation] NFKBIB NGFR [activation] PDE5A ITPR1 [inhibition] CCAR2 CEP170P1 [inhibition] HSP90AB1 AURKA [activation] ATF2 BATF [activation] CCNA1 PGR [activation] SNAP25 STXBP6 [activation] ABL1 NCOA3 [activation] ROCK1 CDK15 [activation] PTBP3 TP53 [activation] GBAS ULK1 [inhibition] PTPRF FRS2 [activation] CAMK4 RBPJ [inhibition] CMA1 MMP1 [activation] CAPN1 NFKBIA [activation] FBXW7 MAP4K1 [activation] WAS PACSIN3 [activation] ACACA MLLT3 [activation;inhibition] TRAF6 ETFA [activation] LY6E FCGR2B [activation] GNG13 GNAT3 [activation] EPOR KITLG [activation] TRAF6 TOMM70A [activation] PLCG1 DAPP1 [activation] KRT35 GRB2 [activation] SHC3 GOLGA2 [activation] USP19 GCN1L1 [inhibition] IL3RA NR0B2 [activation] EIF4A3 EIF4G1 [activation] PPP2CA IKBKB [activation] PASK CREB1 [activation] MYC CHD5 [activation] PTPRF IKBKE [inhibition] HSF4 MAPK14 [activation] KIF23 STK11 [activation] KDR CAV1 [activation] NME2 HSF1 [activation] NRAS FANCC [activation] GRB2 HNRNPK [activation] KCNA3 KCNA2 [activation] DDX27 ARRB2 [activation] EIF2B5 EIF2B1 [activation] LAMB1 PA2G4 [activation] PTPRK GHR [inhibition] EPAS1 ARNT2 [activation] FAM9B BARD1 [activation] CCNB1 MFN1 [activation] HLA-F B2M [activation] STAT5A POU2F1 [activation] PIK3R1 ARHGEF11 [activation] EGFR YWHAE [activation] HMGB1 TP73 [activation] RHOA SPRED2 [activation] TSC22D1 ACVR1 [activation;inhibition] TSC1 YWHAG [inhibition] SMAD4 RALA [activation] CCHCR1 ZFYVE19 [activation] 页 319 共 454


2016/4/8 19:14

LAIR1 CSK [activation] NCK1 BRD4 [activation] FARSB DDA1 [activation] PLCG1 RAG1 [activation] PHKG2 PRKDC [activation] SMAD1 BUB1 [activation] TRPC4AP RIPK1 [activation] PDGFA A2M [inhibition] LRP1B LRPAP1 [inhibition] PTGES3 FTSJ1 [activation] PXN PTPRG [activation] SNX1 F2R [activation] LRPAP1 RANBP2 [inhibition] XPNPEP1 POLA2 [activation] NOTCH2 CNTN1 [activation] PDDC1 APP [activation] SRI STAT3 [activation] MAPKAPK3 RB1 [activation] DAPK3 RHOD [activation] GLRX5 APP [activation] MDM2 BAIAP2 [activation] WASF2 ZDHHC17 [activation] MAPK14 MARCKSL1 [activation] GNA12 NAPA [activation] SUMO1 MITF [activation] HES6 HES1 [activation] AGRN CACNA1A [activation] CTTN SDC3 [activation] MAP2K2 MEPCE [activation] DDX39A DDX39B [activation] GPX1 MAPK6 [activation;inhibition] STC2 ARHGEF40 [activation] TAX1BP1 TBK1 [inhibition] CCNE1 RHOBTB3 [activation] CDKN1A ACTB [activation] ATF2 CS [activation] CD47 GNAI1 [activation] JAK2 NCK1 [activation] YWHAG DDX27 [activation] BCL10 TRAF6 [activation] LRRK2 CSNK1G3 [activation] EGFR VAV3 [activation] ABCA2 CDK5RAP2 [activation] RAD54B PRKAA1 [activation] NOS2 CAV1 [activation] PRDM2 SRC [activation] ABI1 TLN1 [activation] ELANE SLPI [inhibition] POU5F1 CTCF [activation] PRKCD ADAM9 [activation] PLCG1 ABL2 [activation] IKBKE TFRC [activation] WDR91 NUDC [activation] UBE2N BIRC3 [activation] PPFIA3 PTPRG [activation] MAPK1 MAP2K7 [activation] DVL2 CCDC33 [activation] HSP90AA1 NLRP3 [inhibition] RSPH3 SMAD3 [inhibition] SRPK1 DDX47 [activation] CUX1 CDK1 [activation] FYN SH3KBP1 [activation] HMGB1 CREBBP [activation] SERPINF2 BCAP31 [activation] GHRL TBXA2R [inhibition] SOCS3 DAB1 [inhibition] SUV39H2 KCTD17 [activation] RBL1 SMARCA4 [activation] GRB2 PNMA5 [activation] YWHAB PRKCZ [activation] RHOU GRB2 [activation] PRKCE EGFR [activation] VTN FGG [activation] NRIP1 ESRRB [activation] CBL DBNL [inhibition] MAP1LC3B ANAPC1 [activation] 页 320 共 454


2016/4/8 19:14

ADORA2B DCC [activation] OPRD1 PRKCA [activation] NOTCH2NL RTN4RL1 [activation] MSR1 NKG7 [activation] PDE4DIP SNCA [activation] STK4 IPO5 [activation] FYN NPVF [activation] ATM SPSB1 [activation] IQGAP1 CDH2 [activation] ATAD3B TP53 [activation] PEX1 RELA [activation] KPNA1 HIST3H3 [activation] PTPRA PTPRD [activation;inhibition] TSPAN4 CD46 [inhibition] HIST2H2BE EP300 [activation] ARFGAP1 GABARAPL2 [activation] IQGAP1 GRIA4 [activation] TLR3 MBL2 [activation] HMGXB4 HABP4 [activation] AKT1 GATA1 [activation] CDK1 NCAPH [activation] TFAP2A COL1A1 [activation] APP ABL1 [activation] IQGAP1 NPHS2 [activation] GRB2 TF [activation] SNTA1 SCTR [activation] FOS SMARCD1 [activation] CCDC112 FSD2 [activation] TUBB4A RELA [activation] CBL CCT8 [inhibition] ATR EGFR [activation] PPP2R5A PPP2R2D [activation] AURKA SRPK2 [activation] TTN DYSF [activation] SRSF6 OBSL1 [activation] SFN CRK [activation] TTLL7 APP [activation] ATM PPP2R5C [activation] RPS6 ICAM1 [activation] IKBKB ZC3H12A [activation] ST7 NFKBIA [activation] WASF2 GAS7 [activation] TRAF2 NCAPH2 [activation] SCAP SREBF2 [activation] WIPF2 WAS [activation] IPO5 LRRK2 [activation] FGFR3 ATF3 [activation] APP ARAP1 [activation] HRK BCL2L2 [activation] UHRF2 PTPRC [activation] RAD52 HSPA8 [activation] ESR1 ACTR3 [activation] CTTNBP2NL STK24 [activation] TP53 RFFL [activation] APP PCK1 [activation] PRKCA DLX3 [activation] HSPB1 TMCO3 [activation] TRAF2 MAP3K8 [activation] MTRNR2L1 PPA1 [activation] MYC SGOL2 [activation] YWHAB ARRB1 [activation] BMPR2 TUBB [activation] MCM7 RB1 [activation] ATOX1 GGPS1 [activation] USP42 SPP1 [activation] LRRK2 TUBG1 [activation] LRRK2 MRGBP [activation] POLA1 RB1 [activation] IGHG1 IGKC [activation] AR RAD9A [activation] EFHC2 CCNG2 [activation] CHMP3 SMAD1 [activation] SHC1 ACTB [activation] CASP1 MAPT [activation] ABL1 NFKBIA [activation] EGFR ERBB4 [activation] 页 321 共 454


PAXIP1 DVL1 TP53BP1 SMURF1 APOE RPA3 PTN FBXO6 GDF9 RTCA CDC5L MYC ADRBK1 HDAC3 ATG7 NOTCH3 MET MPP1 VCAM1 PTPN1 MOAP1 NBN LYPD3 VCAM1 TRADD PTH UBE2W YWHAH CD5 CTBP1 MYL6 CASP8 IPO5 PCK1 CDH1 TLN1 EIF4A3 PTPN7 CDC5L JAK2 SMAD2 RPA3 CRKL SOGA2 STRN3 MRPS28 CD82 ACTG1 MDC1 ATXN1L MPP5 GRB2 SMYD4 FYN MIF ANGPT4 APP CFLAR HRG SF3B4 RAC1 PAK4 SMARCA4 GAB2 MAPK7 SDC3 OBSL1 IRAK1 COPZ1 RAD17 EXOC1 YWHAG TNFRSF4 RARG EIF2S2 HLA-C

2016/4/8 19:14

BTBD16 [activation] LRRK2 [activation] TP53 [activation] MAP3K3 [inhibition] NOS3 [activation] CLINT1 [activation] BCCIP [activation] PPM1B [inhibition] RSRC1 [activation] HLA-B [activation] TRAP1 [activation] ATM [activation] EPHA2 [activation] GEM [activation] FOXO1 [activation] E2F3 [activation] CTTN [activation] GADD45A [activation] PTPN11 [activation] MAPK1 [activation] TNFRSF10A [activation] RFC1 [activation] LSP1 [activation] H2AFY [activation] ATP1A1 [activation] PTH2R [activation] RMND5B [activation] ESR2 [activation] CD2 [activation] MAPK9 [activation] ITGA4 [activation] PIAS1 [inhibition] NUP153 [activation] DDX21 [activation] HRAS [activation] ITGB2 [activation] HNRNPL [activation] CCDC57 [activation] BRD7 [activation] KPNB1 [activation] STAG1 [activation] SCAMP3 [activation] GRB2 [activation] NXF1 [activation] APC [inhibition] TP53 [activation] ITGB2 [activation] GIT2 [activation] CDC27 [activation] RBPJ [inhibition] TP53 [activation] ACKR3 [activation] MYC [activation] GNS [activation] TRAF6 [activation] TIE1 [activation] MB [inhibition] CASP6 [activation] PLSCR1 [activation] GRB2 [activation] FRK [activation] SRPK1 [activation] CCNE1 [activation] YWHAQ [activation] PFDN1 [activation] CSK [activation] MDC1 [activation] MYC [activation;inhibition] UGT1A1 [activation] HUS1 [activation] MYC [activation] DDX5 [activation] TNFRSF9 [activation] SRF [activation] TLE1 [activation] PIN1 [activation] 页 322 共 454


RRAGB BID TERF1 RHOU LRRK2 IL13RA2 ASPM TRPM7 EPHA1 EVL MLH1 PCED1A JAM3 GAB2 IL15RA DYRK1A TIAM1 UNC119 EZH2 MAP3K7 PSEN1 GRM1 BTC YWHAB SYK TRAF2 PARD3 DVL1 NOS3 CDC23 PRKCZ YWHAE STK11 DDX17 MAST3 MDM2 CTTN STAT3 PTPN1 KCNIP4 SKP2 G3BP2 TFRC YWHAE SMAD2 CD44 PAX6 ESR1 WIZ TRAF6 PIN1 LYN MTNR1A BCL3 RUNX1 KCNC1 EGFR EPSTI1 NUP214 FBXO31 RASSF8 MLH1 AR ACTG1 BHLHE40 EP300 IK RPA1 PSENEN CCDC36 PRLR PAXIP1 RXRA PPP2CA PLXNA1 LCE3A

2016/4/8 19:14

RRAGA [activation] BCL2A1 [activation] BLM [activation] PTK2B [activation] YME1L1 [activation] CASP8 [inhibition] PLK1 [activation;inhibition] ANXA1 [activation] HSP90AA1 [activation] ABI1 [activation] PARVA [activation] CAV1 [activation] PARD3 [activation] YWHAE [activation] CDK4 [inhibition] SRSF1 [activation] PARD3 [activation] CD3E [activation] PPARG [activation] PPP2CA [inhibition] CASP7 [activation] GRASP [activation] ERBB4 [activation] IGF1R [activation] SEC23B [activation] SEC16A [activation] HSPA6 [activation] NCK2 [activation] MAST1 [activation] SH3KBP1 [activation] TRIM41 [activation] ARRB2 [activation] WDR6 [activation] ESR1 [activation] PKP3 [activation] RASSF6 [activation] WAS [activation] PTK2 [activation] CCL5 [activation] PSEN2 [activation] CCNB1 [inhibition] DDX24 [activation] LAPTM4B [activation] PRKCI [activation] GFM2 [inhibition] MSN [activation] TBP [activation] ZNHIT3 [activation] NOTCH1 [activation] PPP4R1 [activation] CTNNB1 [activation] DDX21 [activation] MTNR1B [activation] ANKRD28 [activation] CBFA2T3 [activation] CAMK2A [activation] NLRP10 [activation] CASP8 [inhibition] SOX2 [activation] ATM [activation] YWHAG [activation] ACER3 [activation] POU5F1 [activation] RPS6KA5 [activation] PLEKHB2 [activation] HMGN2 [activation] PFN2 [activation] CSNK1A1L [activation] THBD [activation] MVP [activation] YWHAG [inhibition] H1FX [activation] TAF1B [inhibition] SMURF1 [inhibition] PLXNB1 [activation] HSPB1 [activation] 页 323 共 454


2016/4/8 19:14

PTTG1 BTRC [inhibition] TGFB1 SDC2 [activation] PRKCZ HRAS [activation] NAT2 ATM [activation] KLB FGF21 [activation] CALU ATF2 [activation] HELQ XRCC2 [activation] GRB2 NCK1 [activation] RBP4 GRB2 [activation] PFN1 DNM2 [activation] FOXA2 OTX2 [activation] DNAJA2 EPAS1 [inhibition] QRSL1 PPBP [activation] NEDD9 NFKBIA [activation] PPIA PCNA [inhibition] ESR1 NCOA1 [activation] GNAQ ADHFE1 [activation] ATR CINP [activation] CDK4 KLHL32 [inhibition] CARD16 CARD17 [inhibition] NR1D1 INPP1 [inhibition] NR1H3 HSP90AB1 [activation] PRMT1 VCAM1 [activation] ARHGDIA CASP3 [activation] IRS2 MPL [activation] SIPA1L2 TGM2 [activation] CDK1 CD8A [activation] VASN TGFB3 [activation] IRAK4 SASH1 [activation;inhibition] CTNNB1 MAPK8 [activation] MYL12A TRAF6 [activation] STK3 CDK3 [activation] FBXO6 EIF4A3 [activation] EIF3A CD81 [activation] GABRA3 SDCBP2 [activation] RHOBTB3 CCNB1 [activation] PRMT7 PIK3CG [activation] TP53RK LRRC2 [activation] LIMK2 GSN [activation] PLK1 USP20 [activation] BCR PTPN11 [activation] CASP3 PSEN2 [activation] YWHAG PRKCD [activation] MBP CCNH [activation] PTPN11 PIK3R2 [activation] FBXW7 DCLRE1C [activation] SMAD6 BAMBI [inhibition] VRK2 MAP3K7 [activation] ARHGEF7 TUBB4A [activation] CNTFR HN1L [inhibition] AIRE FYN [activation] GNB1 NUDCD3 [activation] SOX6 POMGNT1 [activation] TP53BP1 ANAPC2 [activation] HNRNPA3 ICAM1 [activation] KRT31 GNAI2 [activation;inhibition] INS CTSB [activation] BRK1 PCDH18 [activation] NXF1 DEPDC7 [activation] HOXA7 JUNB [activation] PDHA1 ITGA4 [activation] CENPO FOS [activation] PRAM1 TP53 [activation] NAA16 SMURF1 [inhibition] SRPK1 ZRANB2 [activation] NXF1 HSPA4 [activation] MAP1B STK4 [activation] FYN PLCG2 [activation] DAB1 ERBB2 [activation] NOTCH2NL LIMS2 [activation] CAMKK1 APP [activation] ARNTL2 NPAS2 [activation] HSPA2 HSPH1 [activation] AURKA KIF11 [activation] BCL2L11 UBC [activation] HNRNPU ICAM1 [activation] 页 324 共 454


RAD51 UNC5A CSNK1G2 C3AR1 FAM154A DSG1 PML NR3C1 CDC42 ACTR2 PPFIBP1 MCM6 FGFR1 DRD2 GRB2 SRC IGSF8 YLPM1 SSTR3 TRBC1 ADCY5 FGA CSNK1G1 FRS2 NHP2L1 RIC8A STK31 ICT1 NCOA2 FAP SNRPA1 RFX6 SCUBE1 RALA PRKACA ERC1 MOB2 ARPC4 RPL31 CHEK1 NXF1 OXSR1 PPP1CC CTBP1 GNAI1 RAPGEF3 CMYA5 IL1RL2 ARRB1 PKM ARF6 PPP1CA LMNB1 BRD7 EGFR RAD21 EIF2B2 SMAD1 CHUK MRAS STX7 PRKCA NOTCH1 TES E2F1 HSPBAP1 HSPA4L HSPA4L LRPAP1 DDX17 LRRK2 IRF7 NFKB2 CDX1 ANXA2 LATS1

2016/4/8 19:14

XPO1 [activation] DAPK1 [activation] PPP1R14A [inhibition] SNTA1 [activation] FAM124A [activation] SSSCA1 [activation] H2AFX [activation] NFKB2 [activation] RAC2 [activation] HLA-B [activation] PPFIA3 [activation] CCNA1 [activation] EPHA4 [activation] KCNJ6 [activation] SPECC1L [activation] BAAT [activation] CD81 [activation] GRB2 [activation] TP53 [activation] TRAC [activation] PRKCA [activation] CDH5 [activation] RELA [activation] SOS1 [activation] SRPK3 [activation] GNA13 [activation] ESR2 [activation] MRPL27 [activation] STAT6 [activation] VIP [activation] ICAM1 [activation] NEDD9 [activation] SCUBE3 [activation] RAP2A [activation] NFKB1 [activation] SMAD2 [activation] EIF4A3 [activation] EIF1B [activation] CRKL [activation] AKT1 [activation;inhibition] RFXANK [activation] CAB39 [activation] WDR92 [inhibition] EP300 [activation] ADRA2A [activation] RANBP2 [activation] BZW1 [activation] IL18 [activation] NFKBIA [activation] EGLN1 [activation] TRMT112 [activation] PRR16 [activation;inhibition] ATF4 [activation] SMARCA4 [activation] AKT1 [activation] EIF3D [activation] CSNK2A2 [activation] ARL4D [activation] FKBP5 [activation] RAF1 [activation] VTI1B [activation] CCDC8 [activation] STK38 [activation] ENAH [activation] ANAPC5 [activation] ARHGEF5 [activation] YAP1 [inhibition] DOK2 [activation] SUMO2 [inhibition] TP53 [activation] BAG1 [activation] ALK [activation] CCAR2 [inhibition] SOX2 [activation] SOS1 [activation] DNAJC11 [inhibition] 页 325 共 454


2016/4/8 19:14

EP300 PAX6 [activation] PIK3CG NOTCH1 [activation] EZH2 HSPB1 [activation] CD81 HIST2H3A [activation] CDKN1B CHUK [activation;inhibition] OPRM1 DOK5 [activation] NRXN1 SIPA1L1 [activation] HLA-B CAPZA1 [activation] CAPN11 UNG [activation] CSF2RB GNB2L1 [activation] TSSK3 EFHC2 [activation] BCAP31 ACTG1 [activation] ASAP1 SRC [activation] KIAA1958 SOCS3 [activation;inhibition] CCDC174 EIF4A3 [activation] LATS1 SPERT [inhibition] DHX34 GSK3B [activation] TGFBR1 NUAK2 [activation] HSP90AB1 MAP4K1 [activation] CREBBP HOXB1 [activation] MLH1 ATM [activation] SELPLG MSN [activation] CITED2 HNF4A [activation] SMARCA2 MYB [activation] MAGED2 PCK1 [activation] BTK SYK [activation] ASAP2 THSD7A [activation] UBE2I PPARG [activation] NRXN1 NXPH3 [activation] RIPK2 EZR [activation] MDM2 NUP188 [activation] ARRB2 RALGDS [activation] CBLL1 CDC42 [activation] FHL3 PTPN6 [activation;inhibition] MMP14 TIMP4 [activation] HNRNPK ICAM1 [activation] INS RB1 [activation] PIK3R1 ARHGAP17 [activation] SMAD4 FAM84B [activation] SPP1 RANBP9 [activation] TP73 ASPM [activation;inhibition] AKT1 AGR3 [activation] CALM1 GRB7 [activation] HIST1H1B EHMT2 [activation] EIF3I CD81 [activation] NBN CCNE1 [activation] E2F1 CDK8 [activation] ACACA UBC [activation;inhibition] RTKN YWHAB [activation] PBX1 KAT2A [activation] SLC9A3R2 PDGFRB [activation] ULK1 ATG5 [activation] ARF1 SPAG9 [inhibition] LNX2 CXADR [activation] FYN FCER2 [activation] MAP3K11 RHOG [activation] SIK1 YWHAZ [activation] SPRR2A AKT2 [activation] DCD ILK [activation] PKM STK4 [activation] DDX5 MAST3 [activation] TTC32 MYOG [activation] KRIT1 FAS [activation] UBE2E3 TGFBR1 [activation] HIST3H3 BIRC5 [activation] ICAM1 RPL26L1 [activation] SP1 HSPA8 [activation] PPP6C MAP3K7 [activation] RAP2C ADRB2 [activation] ACVR1 CHN1 [activation] ANKS3 NXF1 [activation] CHEK2 PRMT2 [activation] LTBP4 IGHG1 [inhibition] NEDD4 CASP7 [inhibition] BARD1 BRD7 [activation] SRPK1 NSG1 [activation] 页 326 共 454


2016/4/8 19:14

PPARGC1A BCL6 [activation] KAT2B RELA [activation] PTPN6 INSR [activation;inhibition] CASP3 DCTN1 [activation] MEP1B PRKCD [activation] NAB2 EGR2 [activation] PRKCQ LYN [activation] ASB2 KMT2A [activation] CADPS2 DRD2 [activation] CXCL9 DPP4 [activation] NFKB2 NFKB1 [activation] MLLT4 RIN1 [activation] TLR9 PRKCZ [activation] DNAJA3 RASA1 [activation] SPARC PDGFB [activation] CCBE1 STX11 [activation] PBRM1 HIST3H3 [activation] ATP1A1 SRC [activation] ESR2 RPS17 [activation] MS4A2 SYK [activation] F11R PRKCA [activation] SOD1 HOXB2 [inhibition] JUN GSK3B [activation] IRAK4 EIF4EBP1 [activation;inhibition] CDC25B MELK [activation] MYOD1 DDX5 [activation] CYCS BCL2L1 [activation] VDR STAT1 [activation] GLI1 RPS6KB1 [activation] FOXM1 TCF7L2 [inhibition] TIRAP RPTOR [activation] PPME1 PPP2R1A [activation] MAPK1 LAMTOR3 [activation] OBSCN MYC [activation] RANBP3 RAN [activation] LAS1L PYHIN1 [activation] HSP90B1 H2AFX [activation] NCK1 ARHGEF11 [activation] SYN1 SRC [activation] HLA-B SMC2 [activation] KPNB1 MDC1 [activation] PCNA CLSPN [activation] NCOA2 DDX17 [activation] ADRB2 GNAI2 [activation] IRF1 HSP90AA1 [activation] ENO1 TOMM40L [inhibition] DYRK1A SIRT1 [activation] NCKIPSD GRB2 [activation] CR2 TP53 [activation] PRNP KIAA1191 [activation] TNFSF14 TRAF3 [activation] DAB1 LRP8 [activation] BARD1 CDK13 [activation] PNPLA2 SMAD9 [activation] APC2 AXIN2 [inhibition] EPHB4 JUN [activation] FAM27E3 IRS4 [activation] MDM2 FOXO4 [activation] IL6R IL6ST [activation] PRNP GRB2 [activation] RAC2 RTKN [activation] BDNF INPP5K [activation] FLT1 NCK1 [activation] RAD54B DMC1 [activation] IGF2 NMRK2 [activation] NFKB2 IQGAP1 [inhibition] BRCA1 CHEK2 [activation] RASSF1 RASSF2 [inhibition] WASF1 CDC42 [activation] KAT2A HSD11B2 [activation] PIN1 JAKMIP2 [activation] GATA1 RB1 [activation] KPNA1 BCAR3 [activation] MRPL10 ICT1 [activation] STAT3 FES [activation] PAK1 PYCARD [inhibition] 页 327 共 454


2016/4/8 19:14

EGFR CLPP [activation] POT1 CTC1 [activation] ARPC2 CDH1 [activation] PTEN CCNE2 [activation] LIN37 MYBL2 [inhibition] MLH1 ACO2 [activation] NXF1 ZNF207 [activation] PTPRK INSR [inhibition] TLK1 SNAP23 [activation] PLK1 BLM [activation] VCAM1 PPP1CC [activation] KANSL1 HSPB1 [activation] VAV1 PTPN6 [activation;inhibition] STX4 GOSR2 [activation] AXIN1 SENP2 [activation] SMAD1 RUNX1 [activation] PRKAA2 PIK3CG [activation] OPRM1 GJA4 [activation] PRTN3 IL1B [activation] MYL12A CHUK [activation] LCA5L SUV39H2 [activation] ARF6 ACLY [activation] RAPGEF4 TRAF2 [activation] INSR IGF2 [activation] FAM86A FAM86C1 [activation] CCNG1 PAK7 [activation] PIK3R1 PDIA2 [activation] E2F1 BIRC2 [activation;inhibition] FYN GRB10 [activation] ANXA2 NCOA3 [activation] PTPN1 STAM2 [activation] SERTAD1 CDK4 [inhibition] CLINT1 JUN [activation] FYB CRK [activation] APP BMPR1B [activation] BTRC NFE2 [activation] FBXW11 CASP3 [activation] HIPK4 RAF1 [activation] PFN1 GPHN [activation] STK38 MAPKAP1 [activation] TP53BP1 CDC23 [activation] RHOG VAV2 [activation] MLLT4 RAP2A [activation] TNFRSF14 GCN1L1 [activation] ARHGAP1 SRC [activation] IL15 ZNRD1 [activation] FAM179B ESR2 [activation] SKAP2 GRB2 [activation] LONRF1 HSPB1 [inhibition] PTPRC NTRK1 [activation] IGF1 WISP2 [activation] LRRK2 SLFN5 [activation] SOX9 NR5A1 [activation] SERPINB6 F10 [inhibition] SMAD3 ESR2 [activation] ARPC4 LRRK2 [activation] SDC3 FYN [activation] PRKACA CFL1 [activation;inhibition] C3 RAD21 [activation] HSPH1 MAP1LC3B [activation] INSR GRB7 [activation] GSK3B MYCN [activation] CCL26 CCR3 [activation] F2R CHRD [activation] NTRK2 SORT1 [activation] YWHAQ EFNB1 [activation] INPP5F YWHAB [activation] CDK2 NFYA [activation] APC DLG3 [inhibition] TERT SMARCE1 [activation] ABL1 YTHDC1 [activation] SOS1 ITSN1 [activation] HSPB1 EIF4G2 [activation] TNIK PRPSAP1 [activation] EHMT1 CTBP1 [activation] ICAM4 ITGAV [activation] 页 328 共 454


CAST PPFIA3 HSPB1 CDC5L MTHFD1L ILK GNAQ GRM4 RHEBL1 BMPR1B TRAF2 USP7 NXF1 CAMKMT LPCAT1 ILK CYP11A1 SMAD9 GABRB3 PPP2CA ADAM22 RAC2 MAPK1 NOTCH1 HDAC4 HIF1A VANGL1 SRPK1 CREBBP CDC20 IL13RA2 PALB2 RAC3 RSRC1 POLD1 NCAPG GNAI3 ESR1 CBL FYB POLI TRAF6 TRAF6 KCNQ1 RPA1 DDX5 CAMK2G PEA15 C18orf25 MAPK9 SMAD3 PYCARD CASP8 UBE2I CDH4 TERF1 SMAD2 RHOD SMAD2 BMP1 COL5A2 CTR9 SOX2 SNW1 NR0B1 EIF3F ICAM1 LUZP4 FOS C14orf105 ARRB1 GPR50 ZDHHC3 SMAD1 ACTB MX1 EXT2 ANXA7 ASB6 FGB EGFR TJP1 MAVS MAP3K7 BAX ANP32B SLC52A2 CDC23 RARRES3 HRAS CD28 LRRC23 C8G C8A UBTF MAPK1 TNIK HARS ZC3H13 EIF4A3 SYK CSF2RB TRIP6 RHOA MYC CNOT11 STAT5A MRPS6 LAT2 PLCG2 YWHAH PRKD2 RPA1 MYO1B ITGB1 RPA3 TP53 TPT1 PRKCDBP MYC C3 PAPPA PIK3CD UBC HSPB1 HSPA4 RHOD TGFBR1 RAVER1 TP53 EZR SPN C3 IGHM CEP250 HSPA2 EGR1 RELA ZSWIM7 RAD51D CREBBP TBP GNAS GNB1 BFAR BCL2L1 NXF1 MRPS27 PTPN1 PLD2

2016/4/8 19:14

[inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] SRPK2 [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] TRAF2 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 329 共 454


2016/4/8 19:14

SRP72 CASP3 [activation] HIST1H1D ITGA4 [activation] CEP55 MYC [activation] TRAPPC11 TP73 [activation;inhibition] PTPN1 MRC2 [activation] BTK FAS [activation] AURKA BAAT [activation] ACTB PLG [activation] CIAO1 POLD1 [activation] FAM118B GNB2 [activation] MAPK9 C1orf94 [activation] SH3KBP1 ARAP1 [activation] YWHAG DFFA [activation] FYN TNF [activation] CSPG4 BCAR1 [activation] HSPB1 KCMF1 [activation] MAPK14 TGFBR1 [activation] INADL MAPK12 [activation] CCDC8 CCAR2 [inhibition] NCK1 DOK2 [activation] PTGS2 CAV1 [activation] VDR SRC [activation] BUB3 PSTPIP1 [inhibition] C15orf59 PPP1CC [inhibition] EIF1AY SRPK2 [activation] YWHAG RAB11A [activation] PTPRC LGALS1 [activation] JUN MTA1 [activation] CLCA2 ITGB4 [activation] HSP90AA1 EIF2AK1 [activation] ANLN MYC [activation] NSUN2 VCAM1 [activation] HSP90AA1 GZMA [activation] PARD6B YWHAH [activation] MTNR1A VAPB [activation] RXRA SMARCA4 [inhibition] GNB2L1 HIF1A [activation] MRPL43 MDM2 [activation] NXF1 CASC3 [activation] ISL1 LMX1A [activation] TICAM2 OPN1LW [activation] GAB2 PLCG1 [activation] ETV4 APP [activation] YWHAG PRKCZ [activation] BTRC PRKACA [activation] PPM1A MAPK14 [activation] CCAR2 CIAO1 [inhibition] YWHAE MAP3K3 [activation] PRKAG1 ULK1 [inhibition] PPARG POU1F1 [activation] VAPB PRKACB [activation] PTGDR MAPK1 [activation] ATM BCAS3 [activation] CNTNAP1 ABL1 [activation] RELA CTNNB1 [activation] POMC NRD1 [activation] NCOA3 NFKB1 [activation] PTK2B PITPNM1 [activation] AMH ARL8B [activation] RAC1 STAT3 [activation] APH1A BHLHE40 [activation] NFKB1 ACTG1 [activation] MCM3 VCAM1 [activation] PPP1R1B KLHL6 [inhibition] SRPK1 SRSF8 [activation] HIST1H2BC EGFR [activation] SRPK2 DDX39A [activation] NR1D2 NR1D1 [inhibition] PIAS1 SERBP1 [inhibition] CRY2 PER3 [inhibition] EP300 PLK1 [activation] MAG MBP [activation] PTPLAD1 VAPB [activation] IFNW1 APP [activation] BARD1 DDX20 [activation] STYK1 HSP90AA1 [activation] 页 330 共 454


2016/4/8 19:14

FST BMP5 [inhibition] CD7 SECTM1 [activation] UGDH GRB2 [activation] EHMT2 CBX3 [activation] C3 LAMA1 [activation] TRAFD1 CDK20 [activation] AARSD1 GNA13 [activation] BID TLE1 [activation] SRPK2 PPIA [activation] NXF1 PIBF1 [activation] FUNDC2 RGS1 [activation;inhibition] GSK3B PFKFB4 [activation] DNM2 TRIP10 [activation] MAVS RIPK2 [activation] MAP2K3 APP [activation] APC NAV2 [inhibition] MAP3K14 EGFR [activation] ARHGEF6 PAK3 [activation] ARF6 APP [activation] RASA1 DOK2 [activation] ICK CDC7 [activation] EPRS TAB1 [inhibition] CACNA1C CACNB3 [activation] PIK3R2 PIK3R1 [activation] CREBBP NUP98 [activation] COPS8 TP53 [activation] AURKB HNRNPA1 [activation] LTA4H HLA-B [activation] CASP3 EIF4B [activation] CRTC2 LGALS3BP [activation] PRMT1 NRIP1 [activation] TFRC SGTA [activation] KCTD12 ARAP1 [activation] SRPK1 ABCF1 [activation] MAPK13 HNRNPA1 [activation] MAU2 NOTCH1 [activation] FANCC FANCA [activation] EPPK1 GRB2 [activation] TGFBR1 CDK14 [activation;inhibition] TP53 VASP [activation] SLC26A8 NXF1 [activation] MAPK12 MBP [activation] ASIP F11R [inhibition] MAP2K1 LAMTOR3 [activation] GDF9 ADPGK [activation] TRAF6 YARS [activation] TRAF2 NT5DC2 [activation] YWHAZ PGLYRP1 [activation] HSP90AB1 SGK2 [activation] EPHB2 ITSN1 [activation] RHOC DAAM1 [activation] SHC1 ITGB4 [activation] CDK1 HMGA2 [activation] IL24 LSP1 [activation] GAPDH CDKN1A [inhibition] NR4A1 PPARG [inhibition] NTRK2 RASGRF1 [activation] TFPI THBS1 [inhibition] MAP3K8 ACY3 [activation] SSTR5 PDZK1 [activation] HLA-C TRIM28 [activation] BAI1 INADL [activation] SFN SIPA1L1 [activation] RABGAP1 TWIST1 [activation] HSP90AB1 RELA [activation] HIST1H1C STK4 [activation] MAPK9 EGFR [activation] SMAD2 LEF1 [activation] GRB2 SIT1 [activation] H1FX EGFR [activation] GRB2 APOL5 [activation] YTHDC2 IRAK1 [activation;inhibition] ANXA2 MAP3K4 [activation] COPS6 EDN1 [activation] MAGED1 IRS4 [activation] DVL2 RHOXF2 [activation] 页 331 共 454


2016/4/8 19:14

MAPK3 VDAC1 [inhibition] CD200 HUS1 [activation] SRCAP EP300 [activation] CAMK2B MAD2L2 [inhibition] ARHGEF7 SCRIB [activation] JUND MDM2 [activation] JUNB YY1 [activation] CDKN2A HSPA8 [inhibition] COL1A2 PDGFB [activation] LATS1 CDK2 [inhibition] STAT1 ESR1 [activation] PSD4 ARL14 [activation] PRKCD IBTK [activation] TNFRSF17 TNFSF13 [activation] CD226 FYN [activation] CASP6 HTT [activation] CDC20 SOSTDC1 [inhibition] CHCHD2 EHMT2 [activation] CDK5 CDK16 [activation] ITCH SMAD2 [activation] EP300 SMAD3 [activation] IL17RE IL17RA [activation] SLC39A1 PRKCZ [activation] RRP1 GABARAP [activation] ANKS1A SFN [activation] PIK3R2 HSPA8 [activation] HSP90AA1 MAP3K12 [activation] CDC42 DAAM1 [activation] IRAK3 CDCA5 [inhibition] NOTCH2 JAG2 [activation] COPS6 MAPKAPK3 [activation] LYZ ELN [activation] EGFR PLD2 [activation] RAD52 UBE2I [activation] MYC SMC6 [activation] ANKRD17 AURKB [activation] ITCH DVL3 [activation] YTHDF3 RPA3 [activation] SKP2 DUSP1 [inhibition] LYN ARHGAP19 [activation] NOTCH2 PSMC3IP [activation] KANSL1 TP53 [activation] ARPC3 ARAP1 [activation] SETD7 SERTAD1 [activation] PPARGC1A NCOA1 [activation] RAD52 MCM2 [activation] OGT FOXO4 [activation] USP2 CCND1 [inhibition] PNPLA2 GBF1 [activation] BCR SRC [activation] GNB3 GNAI3 [activation] OPRM1 GPRASP1 [activation] TREM2 TYROBP [activation] APP PARD6B [activation] HNF4A NR3C1 [activation] LARS CCDC8 [activation] MTNR1B ITM2C [activation] MYC MIB1 [activation] RPA3 RAB5C [activation] ATF2 FSCN1 [activation] MTOR LAMTOR5 [activation] DCC PTK2B [activation] PFKP ILK [activation] CFTR DNAJA1 [inhibition] PGR SORBS1 [activation] HCK CRKL [activation] RXRA PRMT2 [inhibition] NUP62 TRAF3 [activation] GTF2A1 TAF1 [activation] SRC KCNQ5 [activation] SRPK1 IKBKG [activation] PAK2 EIF3I [activation] DOCK11 CALM1 [activation] MAP3K7 PEBP1 [inhibition] VASP NXF1 [activation] SAT1 HSPB1 [activation] 页 332 共 454


2016/4/8 19:14

MVP TEP1 [activation] C11orf68 EIF4H [activation] UBC PLCE1 [activation] EHMT1 SMARCAD1 [activation] FOXM1 CHEK2 [activation] RIPK1 DNAJA1 [inhibition] ATF3 ACTB [activation] SNAP25 GOSR1 [activation] PRKCH PPP1R14A [activation] CRK DLGAP4 [activation] LPAR2 BCL6 [activation] SGTA GIP [activation] ARF1 INSR [activation] MAPK13 YWHAZ [activation] PRKAA1 PPP2R1B [inhibition] KLHL12 C1QTNF2 [activation] FGFR1 HSPG2 [activation] SH3GL2 PAK2 [activation] TRAPPC9 IKBKB [activation] STX7 ELAVL1 [activation] PLCG2 PLXNB1 [activation] PDGFRB HSP90AB1 [activation] XBP1 HM13 [activation] CNTF KRT40 [activation] AR BTG2 [activation] OBSL1 CCT8 [inhibition] LCE2A RGS17 [activation;inhibition] BMPR1B FANCL [activation] BMPR2 ACVR1B [activation] SRPK1 CRHR1 [activation] RPS6KA5 DDAH2 [activation] NGFRAP1 NTRK3 [activation] EP300 MCM4 [activation] PGR FGFR2 [activation] CTCF SMAD3 [activation] MAPK3 GATA4 [activation] FGF2 DCN [activation] H2AFX YWHAZ [activation] CAV1 ERBB2 [activation] GDF11 WFIKKN1 [activation] DIABLO MAML2 [activation] TBRG4 ASAP2 [activation] LRRK2 HOGA1 [activation] YWHAE EIF4B [activation] MDM2 HSPH1 [activation] DDX20 MYC [activation] PC EGFR [activation] MYLK3 HSP90AB1 [activation] PRKCZ RELA [activation] STK11 ZNF189 [activation] ARRB2 MAP3K5 [inhibition] TIMP2 ITGA3 [activation] BCL2L1 PPP1CA [activation] HSPB1 CASP3 [activation] RAB10 RPA1 [activation] NUDC WDR16 [activation] NEO1 TTN [activation] GTPBP2 SUV39H1 [activation] JUP CTNNA2 [activation] PDLIM7 PRKCB [activation] RBL1 CD2BP2 [activation;inhibition] DDIT3 CDK6 [inhibition] KCNA2 NEU1 [activation] TUBGCP6 NXF1 [activation] STK11 CDC14B [activation] CHGB POLD1 [activation] RPS6KA5 ETV1 [activation] SH3KBP1 PIK3CA [activation] POLD1 CD247 [activation] NUAK2 SMAD4 [activation;inhibition] LAS1L LRRK2 [activation] MRPS34 DDX56 [activation] CASP4 MYCBPAP [activation] GNAO1 CRHR1 [activation] GRB2 DLD [activation] INADL NLGN2 [activation] 页 333 共 454


2016/4/8 19:14

SMARCB1 CHD7 [activation] MRPL14 ICT1 [activation] PTGES3 EGFR [activation] DAB2 HSPH1 [activation] COL5A1 BMP1 [activation] PPP1R13L PPP1CC [inhibition] EP300 CDX2 [activation] LHX3 ISL1 [activation] KIF5B APC [inhibition] USP11 MAPK14 [activation] MDM2 CFL1 [activation;inhibition] FOXP3 RELA [activation] IL6 HRH1 [activation] GZMB ELANE [activation] AR CDC25B [activation] PHLDB2 YWHAB [activation] BLM RPA1 [activation] SKIV2L CDKL5 [activation] KIT PTPN6 [activation] F11 KNG1 [activation] OPRK1 WLS [activation] MTA1 TP53 [activation] ACACA MCC [activation;inhibition] ESR1 SMARCA4 [activation] CCNH CCDC33 [activation] KLK7 CCND1 [activation] FAM9B UBE2E2 [activation] FBXO6 TTC17 [inhibition] CREB1 KIAA2026 [activation] APP HMGCS2 [activation] GNAQ CXCR5 [activation] MYC ARFGAP1 [activation] PDHB GRB7 [activation] RPTOR AKT1S1 [activation;inhibition] IRS1 DDR1 [activation] REV3L REV1 [activation] G3BP1 PDPK1 [activation] MME EDN2 [activation] PTPN11 IQCB1 [activation;inhibition] GPSM1 TRIP13 [inhibition] BTK CBL [activation] NR3C1 DAP3 [activation] CDC5L SEH1L [activation] BAD PIM3 [activation;inhibition] IPO5 ITGA4 [activation] AKT1 PDE3B [activation] ESR1 RPS6KA1 [activation] NGFR RIPK2 [activation] CTNNB1 ZIC3 [activation] RPS6KA1 VASP [activation] NXF1 TMEM164 [activation] CAMK2G USP19 [activation] UBE4B CASP7 [activation] FAAP24 LRRK2 [activation] GRB2 APOH [activation] BTG2 SMAD1 [activation] CCDC8 F5 [inhibition] APPL1 KIAA1737 [activation] SMAD2 PPP2R1A [inhibition] ATF2 RAB14 [activation] TP53 NCOA1 [activation] TAB2 NFKB1 [activation] GNA14 ADRB2 [activation] KLF13 GATA6 [activation] UBE2N TP53 [activation] ATF2 RAB2B [activation] RHOA SMURF1 [activation] GNAZ EYA1 [activation] TNF CARS [activation] FMNL1 FLI1 [activation] TTC5 CAMK2D [activation] RASA1 CASP3 [activation] RB1 CASP10 [activation] NCK1 NTRK2 [activation] CSF3R FTH1 [activation] MYOG ELSPBP1 [activation] 页 334 共 454


2016/4/8 19:14

IFNGR2 CAMK2D [activation] SRPK2 ATAT1 [activation] GLOD4 NR4A1 [inhibition] MYO3A TGFBR1 [inhibition] MRPS18B RB1 [activation;inhibition] USP6NL GRB2 [activation] RIPK1 SUMO1 [activation] STK3 MAP1LC3A [activation] PHLDA3 TRIO [activation] CELA1 CSN2 [activation] CCNDBP1 MOS [activation] TRIM69 SKIL [activation] PRKCB ANXA7 [activation] MYC PPP1R15A [inhibition] SERPINA4 YAE1D1 [inhibition] CDK19 ERC1 [activation] NBN CD3EAP [activation] BAD PPP1CA [activation;inhibition] SLC25A6 MDM2 [activation] HLA-B CD81 [activation] SERPINF2 F13A1 [activation] FCGR2B PLCG1 [activation] ATPIF1 GSK3B [inhibition] PXN APC [activation] EP300 DAO [activation] VARS MAPK11 [activation] DOC2B UNC13B [activation] PTK2B DLGAP3 [activation] ST14 AKT1 [activation] NCOR1 MYB [activation] HSPA4 RHO [activation] CDK3 HSP90AB1 [activation] DDAH2 GADD45G [activation] RAC1 FLNA [activation] ETS1 CPLX2 [activation] PRMT1 SSSCA1 [activation] CTNNB1 CSNK2B [activation] MCM7 CTNNB1 [activation] PTN PPP2CA [inhibition] EIF3I NR1H3 [activation] PTPN14 YWHAB [activation] KCNF1 OPRM1 [activation] EPOR PTPN6 [activation;inhibition] RAB5A PIK3R1 [activation] GABBR1 RGS4 [activation;inhibition] YTHDC1 EIF4A3 [activation] VCAM1 MCM2 [activation] CDK1 ERCC2 [activation] CDH1 CREBBP [activation] HIST1H4A BRD7 [activation] MAX CASP7 [activation] ERH PAXIP1 [activation] VGF LRRK2 [activation] ATF2 ATF7 [activation] RALGPS2 YWHAG [activation] PTK2B FGFR3 [activation] SMC4 CCDC8 [activation] BARD1 MAPK1 [activation] FANCG PRDX3 [activation] ADRA1B NOS1 [activation] PRMT1 NXF1 [activation] CCDC155 CXCL9 [activation] GRB2 SOCS1 [activation] TRAF1 GEM [activation] DNAJB5 CCRN4L [inhibition] EIF2B5 CHMP2A [activation] APP LCP2 [activation] KCND2 KCNIP4 [activation] CEP250 DDX24 [activation] RBPJ GADD45A [activation] GNL3 ESR2 [activation] OSR2 LIMS1 [activation] TSC22D1 TP53 [activation] PIK3CA BEX2 [activation] CUX1 EHMT2 [activation] MCM7 ZAK [activation] 页 335 共 454


2016/4/8 19:14

CPNE1 ARRB2 [activation] HIST1H4A TAF1B [activation] CCDC8 PLXNB2 [activation] ANK1 CD44 [activation] MSANTD3 VSTM2A [activation] LRRK2 POLDIP3 [activation] TGFBR2 HSP90AA1 [activation] MDM2 ITCH [activation] JAK3 IRS2 [activation] NRTN GFRA1 [activation] RAB11A RAB11FIP1 [activation] MRPS27 YWHAZ [activation] MYOD1 ESR1 [activation] NGFR MAPK1 [activation;inhibition] KIF23 RNASEL [activation] CCDC8 GAPVD1 [activation] PTPN11 PRLR [activation;inhibition] MAPT MAPK11 [activation] CREBBP EIF2B1 [activation] GABARAPL2 KIAA1958 [activation] RGS6 GNB2 [activation;inhibition] C1R EP300 [activation] CNIH4 ILK [activation] RALB PYCARD [inhibition] TNFRSF13B MYD88 [activation] MAP4K4 MDM2 [activation] CDKL5 ABL1 [activation] MAP2K1 GRB10 [activation] HELB RPA1 [activation] SNAP25 ZDHHC17 [activation] FAM74A4 NOTCH2NL [activation] AARSD1 GNAL [inhibition] EIF3E CNTF [activation] MAPK6 SOCS3 [activation;inhibition] PPARA STAC3 [activation] DLX4 SMAD4 [activation] TIAL1 GADD45A [activation] PPM1B ANXA2 [activation] XIAP NOD1 [activation] KDELR1 SEC23B [activation] HSP90AA1 TRAF2 [activation] HIP1 CASP8 [activation] BARD1 SETDB1 [activation] AURKA HSPA8 [activation] MAP3K7 IRAK1 [activation;inhibition] ARF6 HLA-B [activation] YWHAE RAD52 [activation] POTEKP ERBB3 [activation] BMPR1B STK35 [activation;inhibition] FLT1 CTNNB1 [activation] CDK2 MAPK15 [activation;inhibition] PRKACA SLC2A2 [activation] CASP7 GOLGA3 [activation] FBXL2 AURKB [activation] ISL1 RELA [activation] GNA13 GNA12 [activation] HSPB1 ADRBK2 [activation] CCAR2 TSSC1 [inhibition] HIF1A FBXW7 [activation] SHC1 PPAP2B [activation] NOTCH2NL FAM71E2 [activation] SLC2A5 CCL5 [activation] UBE2H DHPS [activation] ABL2 FBXO38 [activation] TPT1 PER2 [activation] GHRL PTGIR [activation] RPS6KB1 PPP2R2B [activation] KAT2B MECOM [activation] MGLL CHGB [activation] FHL2 E2F1 [activation] PPP2R4 MDM2 [activation] PPM1F CAMK2A [activation] SLC9A3R1 PDGFRA [activation] DDX24 NXF1 [activation] SEMA3B SEMA3A [activation] EGLN3 MAPK1 [activation] 页 336 共 454


2016/4/8 19:14

COL1A1 TGFBI [activation] SH2B2 JAK1 [activation] SEMA4A PLXNB3 [activation] PIK3CA IL13RA2 [activation] NOTCH1 CNOT1 [activation] LUC7L2 NUTF2 [activation] MAP4K5 SETDB1 [activation] C16orf59 NOTCH2NL [activation] TIMP1 ECH1 [activation] NFKB2 HSP90AB1 [activation] CENPF SNAP25 [activation] WDR34 TRAF6 [activation] RARG SRC [activation] STX3 UBC [activation] GRB2 PLXNB1 [activation] NUF2 AURKB [activation] DFNA5 EGFR [activation] LZTS2 RAC1 [activation] PTPRG PDGFRB [activation] MYLK CAMK2G [inhibition] MAPK8 CASP3 [activation] TWIST1 BRAP [activation] KCNK12 AXIN2 [inhibition] WDR6 ILK [activation] CTNNB1 PTPRC [activation] KNG1 APP [activation] KRT40 SHC3 [activation] EFEMP1 TRAF2 [activation] CDK4 ASPM [activation] PGR STAT3 [activation] PPIA ITGA4 [activation] NXF1 YARS [activation] SNW1 EIF4A1 [activation] PDIA3 ADAM10 [activation] VAPB STX1A [activation] OBSL1 DDX54 [activation] SMARCB1 PDPK1 [activation] ABL1 PTGES3 [activation] UBC C5AR1 [activation] RPS13 SPP1 [activation] SMAP2 VCAM1 [activation] PDC CAMK2A [activation] TIAL1 VCAM1 [activation] PAK6 LRRK1 [activation] DSC1 MAPK7 [activation] RIPK2 UBE2I [activation] TLR2 MAP2K1 [activation] FASLG PACSIN1 [activation] CD160 AGTRAP [activation] IGF1 IGFBP7 [activation] ATR MTA2 [activation] CCDC180 STK11 [activation] ACP6 ESRRB [activation] SFN MAP3K2 [activation] SELV PAXIP1 [activation] SMCHD1 BARD1 [activation] BTK GNA12 [activation] ATG5 SIRT1 [activation] STX17 TLR2 [activation] GPSM1 CCDC158 [inhibition] KRAS EPB42 [activation] HEMGN TLR2 [activation] SMC3 HLA-B [activation] HLA-B SUCLG1 [activation] PLCG1 LAT2 [activation] EGFR PTPN6 [activation;inhibition] ESR1 YWHAH [activation] RGS2 RAP1B [activation] UBC DLL1 [activation] GDF9 FXYD6 [activation] HLA-B UBA2 [activation] MYC DNAJA3 [inhibition] EXOC5 EGFR [activation] GRB2 HOMEZ [activation] BARD1 LDOC1 [activation] IQGAP1 LRRK2 [activation] 页 337 共 454


2016/4/8 19:14

GNB2L1 LRRK2 [activation] SNTA1 NOS1 [activation] PRNP NOB1 [activation] FTSJ3 GABARAP [activation] ATF2 JDP2 [activation] RPS15 LRRK2 [activation] CSNK2B CDK11A [activation] ERBB3 HLA-B [activation] IRF8 TRAF6 [activation] EIF2S1 MELK [activation] MTUS2 CDK5R1 [activation] BCAP31 FIS1 [activation] STK11 MLF1 [activation] MAPK1 TNFRSF25 [activation] LCK EZR [activation] TP53 NMT2 [activation] MYB PCDH17 [activation] KPNB1 TRADD [activation] STXBP1 PLD1 [activation] MAPT STXBP1 [activation] CAB39L BCKDK [activation] SNW1 NCAPD2 [activation] LPAR1 KRAS [activation] GXYLT1 TRAF6 [activation] CASP3 PICALM [activation] SMAD4 SMAD6 [activation;inhibition] ZHX1 BCL2L1 [activation] SNAP29 EHD1 [activation] CDC23 INPP5J [activation] E2F1 PKIB [inhibition] PIK3R1 NTRK2 [activation] EXOC3 MLH1 [activation] HOXD4 EP300 [activation] CD2 PSTPIP1 [activation] MLH1 TAGLN [activation] PORCN WNT3A [activation] CSNK2A1 PTPRC [activation] STAT1 EIF2AK2 [activation] YWHAG PAK1 [activation] TFF1 ESR2 [activation] DNAJB11 MYC [inhibition] BID NXF1 [activation] MAP3K2 YWHAB [activation] EHMT1 DNMT3A [activation] CCL3 TGFB1 [activation] ATM MED1 [activation] CASP8 LRRK2 [activation] ACTG1 YWHAQ [activation] COL4A2 OSM [activation] MAPK9 BAZ1B [activation] HSP90AB1 FKBPL [activation] BAI1 ELMO1 [activation] PNP NXF1 [activation] HIST1H2AB ITGA4 [activation] CEBPB RELA [activation] RYR2 CACNA1C [activation] DDX21 MAST3 [activation] PLK1 TP53BP2 [activation] UBE2U MDM2 [activation] PAXIP1 WEE1 [activation] RBBP9 RBL1 [activation;inhibition] EIF2S3 CAND1 [activation] OGT PPP2R2B [activation] SIPA1L2 LATS1 [inhibition] FOS TRO [activation] GRB2 EIF4A1 [activation] MAP3K1 RAF1 [activation] PON2 GRB2 [activation] DLGAP4 SRC [activation] SCARB1 FLT1 [activation] SNTA1 PLCB3 [activation] MEN1 RPA3 [activation] DOK1 SH2D1A [activation] RARA NCOA1 [activation] BUB1B PLK3 [inhibition] STOM EGFR [activation] 页 338 共 454


2016/4/8 19:14

ICAM1 RPS2 [activation] CDK10 NUDCD3 [activation] SMAD3 SMAD5 [activation] MOS USHBP1 [activation] COPA STK4 [activation] IPO7 RAN [activation] NCF1 MAPK14 [activation] FAM131A PHYHIP [activation] GNAQ TTC1 [activation] FECH MDM2 [activation] ZNF321P SRPK2 [activation] LRRK2 SNX9 [activation] DUSP15 ABL1 [activation] CDK1 TFDP1 [activation] PDGFRL SFRP4 [activation] EIF6 ACTG1 [activation] ATF1 CSNK2A1 [activation] DVL2 MAP3K1 [activation] PEPD SPP1 [activation] YWHAG LRRK2 [activation] DKK3 BCAR3 [inhibition] DVL2 CTNNB1 [activation] CTNNB1 DNAJC8 [inhibition] SMC1A POLA1 [activation] CREB3L2 GAS7 [activation] FLT1 STAT3 [activation] PPP2CB SMAD4 [inhibition] SSBP2 IL36RN [activation] PALB2 RAD51AP1 [activation] ITGA4 CD44 [activation] BCAS3 STK11 [activation] C2orf44 CSNK1E [activation] SERPING1 NR4A1 [inhibition] KPNB1 KPNA1 [activation] MAP3K4 RAC1 [activation] ENKD1 DVL2 [activation] SHC1 SHCBP1 [activation] BTRC EP300 [activation] KIT CSF2RA [activation] TRAF2 FAM90A1 [activation] HOXC8 SMAD4 [inhibition] PAXIP1 CAPZB [activation] DAW1 SRPK1 [activation] OLA1 BCL6 [activation] ITCH TGFBR1 [activation] FBXO31 CUL1 [inhibition] PPP1CC TBC1D19 [inhibition] EP400 TP53 [activation] HSPA6 TP53 [activation] CPVL EGFR [activation] SDC1 IL8 [activation] CASP8 IL24 [activation] LAMB1 ESR2 [activation] ESR1 SMAD4 [activation] CHEK2 PLK3 [activation] FLAD1 ICT1 [activation] ACVR1 VEPH1 [activation;inhibition] IL18R1 CD48 [activation] CCL5 EDC4 [activation] PFKFB2 YWHAE [activation] HHEX TRMT6 [activation] FHOD1 RAC1 [activation] FBXO28 PAK1 [activation] UTP18 ERBB2 [activation] BCAR1 SH2D3A [activation] LRRK2 ABL1 [activation] IL3RA NCK1 [activation] RAD9A BCL2L1 [activation] MYB SDC2 [activation] GRB2 DIAPH1 [activation] S100A14 AKT1 [inhibition] GADD45A RARA [activation] CASP8 CASC3 [activation] APPL1 UBE2O [activation] PPM1A PRKAA1 [inhibition] GATA6 EP300 [activation] 页 339 共 454


2016/4/8 19:14

ATAD3A ILK [activation] KRT17 EGFR [activation] ARRB2 OXTR [activation] NFKBIA CAPN2 [activation] YWHAG CFL1 [activation] CDC27 COMT [activation] ADAMTS20 MYC [activation] NFKB1 SPAG9 [inhibition] IL1RAP MC4R [activation] PRKCI GLI1 [activation] CSK FHL2 [activation] RTCB MDM2 [activation] APP KCNMB2 [activation] NPEPPS TIMP2 [activation] ITGA9 PXN [activation] UBE2I AR [activation] CCDC97 NXF1 [activation] HSPA4 YWHAZ [activation] EGFR SEPP1 [activation] HSP90AB1 HCK [activation] TNFRSF14 ITFG1 [activation] NPHP3 UNC119B [inhibition] PAK1 SRGAP2 [activation] DAB2 LRP6 [activation] ADAM9 ITGAV [activation] MAPK1 SYNE2 [activation] ZAP70 CRK [activation] EIF4A3 HIST1H2AD [activation] SLA LAT [activation] ZAP70 SIT1 [activation] NRXN1 SYT2 [activation] CREBBP HIST2H2BE [activation] CRK CBLB [inhibition] MYC MAP3K1 [activation] PIK3C3 SUMO1 [activation] C9orf156 BMPR1A [activation;inhibition] TKT ATG5 [activation] CDKN2C RIF1 [inhibition] EIF2S2 HDGF [activation] BRAP HRAS [activation] RAC1 TIAM1 [activation] PRKAA2 FNIP1 [activation] MYC RPS16 [activation] GLTPD1 LRRK2 [activation] MAP1LC3B HSPA6 [activation] HOXA11 FOXO1 [activation] ENO2 ST3GAL2 [activation] GNAI2 SVIL [activation;inhibition] GYS1 OTUD5 [inhibition] EIF4A1 MEPCE [activation] BCL9L CTNNB1 [activation] DAPK2 ATF4 [activation] TAB1 FADD [inhibition] CDK18 MIPOL1 [activation] TNF BGN [activation] DCC EIF2B1 [activation] LUC7L2 SRPK1 [activation] DNAJA3 ICT1 [inhibition] DVL1 SMAD1 [activation] LRRK1 SOS1 [activation] MVP PTEN [activation] TMED2 F2R [activation] AGFG1 APP [activation] PRKCB CASR [activation] MAPK8 HSF1 [activation] PPP2R2B FTSJ1 [activation] BTRC CDC20 [inhibition] WHSC1 HDAC1 [activation] TGFBI COL1A2 [activation] TXNIP RELA [activation] SRC MAPT [activation] ZDHHC17 DIXDC1 [activation] MEF2A PRKCQ [activation] GNG11 FOS [activation] CAV1 SH2D3C [activation] YWHAB GBF1 [activation] 页 340 共 454


2016/4/8 19:14

MYC SIRT2 [activation] RHNO1 LZTS2 [activation] BCL6 PPARD [activation] ITK CBL [activation] CCR5 CCL14 [activation] ARHGAP12 TRIP10 [activation] FHL2 ARHGAP9 [activation] PCDH10 ABI2 [activation] MECOM FOS [activation] PRKCSH PTPRC [activation] WDR43 NXF1 [activation] NME7 C1orf189 [activation] RALA CCDC8 [activation] GALNT12 CDH1 [activation] TP53 DLEU1 [activation] EGFR ARMC6 [activation] PRPSAP2 MAST3 [inhibition] MAP3K3 CALM1 [activation] POLD1 GSTK1 [activation] GRB2 SEPN1 [activation] CPNE4 SKIL [activation] ESD VCAM1 [activation] VAV1 AR [activation] GRB2 DOCK4 [activation] AKAP4 PRKAR2B [inhibition] CDC7 SUMO3 [activation] IRF3 SERPINB2 [inhibition] RXRA TBP [inhibition] EP300 HOXB3 [activation] CTDSP1 SNAI1 [activation] C16orf45 ENO2 [activation] GOLGA2 CCHCR1 [activation] MAPRE1 APC [activation] GABRR1 PRKG1 [activation] SPP1 CACNG4 [activation] YWHAB CDK14 [activation] TRAPPC3L TRAPPC8 [activation] YWHAH CDC25C [activation] KCTD6 OBSCN [activation] KPNB1 OBSL1 [activation] PPARA NRIP1 [activation] CDK17 TGFBR1 [activation] SUMO4 NFKBIA [activation] SMC3 APC [inhibition] C1orf106 SFN [activation] EP300 KAT2B [activation] SNTA1 CALM1 [activation] BUB1 BAAT [activation] SRPK2 SNRPA [activation] FAM76B SRPK2 [activation] RELB HSD17B4 [activation] NCF4 MLH1 [activation] MYL6 CHUK [activation] RB1 PPARG [inhibition] DNAJA1 NFKB1 [inhibition] POLA2 ASCC2 [activation] ARRB1 PPM1A [activation] PLK1 DNAJB9 [inhibition] TRIP10 PRKACA [activation] HIST1H3A PAXIP1 [activation] HDAC1 HSPA4 [inhibition] HECW2 TP53 [activation] HIST1H3A H2AFX [activation] MIF ILK [activation] BCL2L1 LARP1 [activation] MTTP HSP90B1 [activation] SNAP25 SYT3 [activation] FAM46A BCCIP [activation] WFS1 MAPK6 [activation] EPHB6 CRK [activation] EGFR AGER [activation] BMPR1A FKBP1A [inhibition] TMEM5 GPR3 [activation] NCOA3 CHUK [activation] PIK3R1 IL1R1 [activation] STAG2 MYC [activation] 页 341 共 454


2016/4/8 19:14

HIST1H2BD CD81 [activation] ELOVL1 TWF2 [activation] CASP9 SRF [activation] RECQL5 MCM7 [activation] SMURF1 TP53 [activation] PPARA LAMTOR5 [activation] MYC FOSL2 [activation] SLX4 PRKCI [activation] SNTA1 MAPK12 [activation] DSEL SPP1 [activation] RPL19 TP53 [activation] CAMK4 CAMKK1 [activation] ZNF706 RAC3 [activation] PIK3CA IRS4 [activation] APP CDK18 [activation] SARS2 RAD21 [activation] IQGAP1 ESR1 [activation] ABL1 CASP9 [activation] BAD BCL2A1 [activation;inhibition] PLD2 RPTOR [activation] CSNK2A2 CASQ2 [activation] CAV1 MAP1LC3B [activation] CLSPN RPA3 [activation] GGCX PROC [activation;inhibition] TRAF3 TRAIP [activation] TP53 CRTC2 [activation] ELANE F5 [activation] NOTCH1 HIF1A [activation] WIPF2 GRB2 [activation] ICAM1 ACTN1 [activation] RANBP2 APC [activation] TP53 AIMP2 [activation] RAC1 ARHGEF19 [activation] APP PLEKHJ1 [activation] ADRB2 IDH3A [activation] CRK ABI1 [activation] ARHGEF6 GPRASP2 [activation] TOP1 TP53 [activation] RGS12 ARAF [activation;inhibition] RAD50 MDC1 [activation] RAB5A ALS2CL [activation] SOCS3 CXCR4 [activation] SGTA IGLC1 [activation] CTTN PTK2 [activation] CDK5RAP3 CDH4 [activation] DIABLO PRKCD [activation] GREB1 SMAD4 [activation] XRCC3 ZNHIT3 [activation] STRADA XPO1 [activation] RASA1 DLC1 [activation] SKIV2L2 MAPK11 [activation] CDC37 STK11 [activation] ARPC4 PNMA5 [activation] CBLB MYD88 [activation] TRAPPC9 NXF1 [activation] RAD21 HSP90AA1 [activation] ITCH RIPK1 [activation] PRKCB STXBP1 [activation] MAPK11 ZNHIT1 [activation] CCL2 MMP3 [activation] CCNA2 PCNA [activation] SRPK1 SON [activation] ICAM1 IL2RA [activation] PALD1 IRF7 [activation] FOS ZFYVE9 [activation] NAT2 PALB2 [activation] CACNB1 ATN1 [inhibition] MAPK1 MAP2K4 [activation] HSF1 NCOA6 [activation] PPARG KAT2A [activation] FKBP2 C1QC [activation] ITGB4 PLEC [activation] TRAF6 CALM1 [activation] PRKCH CDK2 [activation] NFATC2 MAPK9 [activation] CASP7 STK24 [activation] 页 342 共 454


2016/4/8 19:14

HABP4 PRKCQ [activation] PPARG CREBBP [activation] C1QTNF1 AVPR2 [activation] GYS1 PRKACA [activation;inhibition] CREM PRKACA [activation] SRPK1 FKBP3 [activation] NXF1 TPD52L2 [activation] KCNS3 HSP90AB1 [activation] BIRC5 CASP7 [activation] MET GRB14 [activation] EIF4E PAK2 [activation] WASF2 DOCK1 [activation] FER EGFR [activation;inhibition] MLH1 HSD17B3 [activation] SRGAP1 YWHAZ [activation] TRIP10 RHOJ [activation] MAST3 YWHAE [activation] CALM1 TNF [activation] GRIA4 EPB41L1 [activation] NGF CRYAB [activation] AKT1 DDX5 [activation] KDR GNAQ [activation] PAFAH1B1 MAP2 [activation] EP300 TTC5 [activation] CDK4 ANKRD12 [inhibition] CCR5 PTK2B [activation] MAML1 PBRM1 [activation] ADRB2 SLC25A6 [activation] ESR1 FHL2 [activation] TRAF5 TNFRSF12A [activation] RPS6KB1 STK11 [activation] CDC37 EIF2AK4 [inhibition] GATA6 CRIP2 [activation] MET STAT3 [activation] SMAD3 PIAS2 [inhibition] KIF23 ECT2 [activation] ATF1 CREB1 [activation] STAT5B STAT5A [activation] KRAS BCL2 [inhibition] SP1 MAN1A2 [activation] TNFRSF14 CD160 [activation] FAM219A POLA2 [activation] SLC6A3 STX1A [activation] SF3B5 SRPK3 [activation] AGPAT1 NXF1 [activation] PCP4 CALM1 [activation] PTK2 NEDD9 [activation] SPHK2 HIST1H3A [activation] CAB39 RAD51 [activation] IGHA1 APC [inhibition] AVPR1B AVP [activation] TCAP FAS [inhibition] PTK2 GZMB [activation] ANXA7 F13A1 [activation] ABCF3 NXF1 [activation] NSUN4 MTERFD2 [activation] POLE POLE2 [activation] TNS3 SRC [activation] NCOA3 PIN1 [activation] GNB2 RAF1 [activation] MAPK6 CASP6 [activation] PRKACA ITPKB [activation] GRB2 VASP [activation] PCK1 FBXO25 [activation] HMGA2 NPM1 [activation] HOXD13 SMAD1 [activation] GRM4 CALM1 [activation] SRSF8 SRPK2 [activation] PDHA2 MYC [activation] EGFR SCAMP1 [activation] HCK ARRB1 [activation] CCHCR1 USHBP1 [activation] GSTK1 CPSF3 [activation] MDM2 KPNB1 [activation] IGHA1 CTR9 [activation] MAP2K4 STX17 [activation] 页 343 共 454


SMAD4 MAPK14 CCDC8 DAB1 GSPT1 PPP2R1A SUMO1 RAN TWF2 PACSIN1 MAP3K2 PIK3R3 RHOJ ERBB2 PLCG1 APP CDH13 EPAS1 PPP1CA ABR BIRC5 HMGN1 SMURF1 APP RAC1 BMPR1A APCDD1 YWHAB BUB1 CAPZA1 STIM1 PLXNA3 MYC EIF2S2 HSPA6 PAXIP1 LYN MTRF1 IKZF3 SKP1 MYOD1 TXNDC17 PTPN11 DAPK1 HSPD1 EIF4A1 C1QTNF9 ICAM1 FAM210A MDC1 HARS2 CREBBP LRRK2 PALB2 PDGFA EIF2B2 LRRK2 ITGB1 HDAC4 AHSG PIM2 PICALM UBTF CDK4 CD4 MYLK EPSTI1 MAPK1 MARK3 PAK4 HSPA4 HLA-A KDR AGAP10 GIT1 ERVK6

2016/4/8 19:14

UBE2I [activation] GDF15 [activation] HSPA4 [inhibition] ITGB2 [activation] ARF6 [activation] TP53 [activation] OGT [activation] RNF2 [activation] KRT36 [activation;inhibition] DNM2 [activation] YWHAG [activation] ERBB3 [activation] SMAD2 [activation] RASA1 [activation] DDR1 [activation] PCDHA7 [activation] ADIPOQ [activation] CREBBP [activation] PPP1R3D [activation;inhibition] ABL1 [activation] CDK1 [activation] NFE2 [activation] ARL14 [inhibition] TRAIP [activation] TOM1 [activation] FBP2 [activation] RXRB [inhibition] ANKS1A [activation] C9orf156 [activation] CHUK [activation] STIM2 [activation] PPP2CB [activation] NFYC [activation] CSNK2B [activation] TNFRSF1A [activation] CPSF3 [activation] EVL [activation] MYC [activation] BCL2L1 [activation] TBK1 [inhibition] C2orf88 [activation] INS [activation] FCGR2B [activation] STX1A [activation] GRB2 [activation] OBSL1 [activation] EIF4G2 [activation] RPL9 [activation] NXF1 [activation] ANAPC7 [activation] ICT1 [activation] ESR1 [activation] HSPD1 [activation] RBBP8 [activation] COL1A1 [activation] EIF2B5 [activation] ZZZ3 [activation] TIMP2 [activation] GNB1 [activation] CDC42 [activation] HSP90AA1 [inhibition] SNW1 [activation] HEMGN [activation] TRAP1 [activation] SPG21 [activation] CTTN [inhibition] FGFR4 [activation] PECAM1 [activation] YWHAZ [activation] CDC5L [activation] CALM1 [activation] EGFR [activation] HSPG2 [activation] HSPB1 [activation] SRC [activation] PYCARD [inhibition] 页 344 共 454


2016/4/8 19:14

BAZ1B SMARCA5 [activation] PRKAB1 MIF [activation] FAM127B HSPB3 [activation] CHUK HSPA9 [activation] MAP3K1 MAPK3 [activation] CD247 NCR3 [activation] RAF1 EFEMP1 [activation] PNMAL1 PARD6G [activation] HSPB1 PRKD1 [activation] RAB5A RIT2 [activation] LAMTOR1 RRAGD [activation] MRPS11 SRPK2 [activation] CAMKMT HSP90AB1 [activation] RXRB NR1H2 [inhibition] SMARCA5 PYHIN1 [activation] RELA ATF4 [activation] HSPA4 SMAD2 [inhibition] CDC25B CDC14A [activation] SH3KBP1 GRB2 [activation] KRTAP19-5 DAB1 [activation] PPP6C NOS2 [activation] MCC RAP1B [activation] PARD3 TIAM2 [activation] STAT3 CTR9 [activation] HIST1H4A NCOA2 [activation] ATR MCM7 [activation] CCS SOD1 [inhibition] CDH7 CDH12 [activation] CRK CELSR2 [activation] FOXL1 BMPR2 [activation] UBE2E2 RNF114 [activation] AKT2 CHEK1 [activation;inhibition] RPAP2 DNM2 [activation] AJUBA BUB1B [inhibition] MEGF6 EGFR [activation] VAMP1 VAPB [activation] MCM5 NFKBIA [activation] HECW2 KMT2A [activation] SRPK2 EGLN2 [activation] ESR2 RRP1 [activation] NUAK2 SMAD2 [activation] MDC1 PRIM1 [activation] EGFR CDCP1 [activation] YWHAH TNK1 [activation] SUMO3 ARPC5 [activation] HSPA4L HSF1 [activation] SATB1 CASP6 [activation] FBXO25 KDR [activation] RB1 TRAP1 [activation] PRKACA RGS10 [activation;inhibition] TP53 PCDHA4 [activation] FZR1 TACC3 [inhibition] DDX24 MYC [activation] MAGED1 NUMBL [inhibition] MAGI2 DSCAML1 [activation] ARRB1 MAPK1 [activation] CSNK1D ARFGAP1 [activation] EPOR KIT [activation] TIAM1 ANK1 [activation] PLK1 ANKRD28 [activation] RPS17 NUDC [activation] JAK2 IKBKG [activation] RAB14 RPA1 [activation] CTNNB1 FHL2 [activation] FZD4 CRELD2 [activation] CYFIP2 ABI3 [activation;inhibition] DDX47 EGFR [activation] RSPO2 SUV39H1 [activation] ERAS PIK3R1 [activation] FGFR2 PIK3R1 [activation] MYC SP1 [activation] CD81 LUC7L2 [activation] YWHAE CDC5L [activation] TYK2 IRS2 [activation] CASP4 CDK2 [activation] WDR5 TWIST1 [activation] 页 345 共 454


2016/4/8 19:14

C2orf44 PDPK1 [activation] EIF4A3 CCDC9 [activation] RXRB DNAJB14 [inhibition] CCR5 CXCR4 [activation] TNFRSF1A ADAM17 [activation] GRB2 AHSG [activation] A2M FARSA [inhibition] CISH CCNE1 [inhibition] PRMT7 HIST1H3A [activation] RPS6 CD81 [activation] MCM7 GFPT1 [activation] PIKFYVE SUMO1 [activation] MED1 GATA6 [activation] SMAD3 E2F4 [inhibition] TGFB1 WHSC1L1 [activation] TAGLN2 RPA3 [activation] AR ESR1 [activation] YWHAZ KPNB1 [activation] ROPN1 RHPN1 [activation;inhibition] NAPB STX5 [activation] RALGAPB RALGAPA2 [activation;inhibition] NTPCR LRRK2 [activation] NCOA1 FOXA2 [activation] MYO1G CD247 [activation] HSP90AB1 CDK4 [activation] BCL6 TWIST1 [activation] ZFP36L1 MAPK14 [activation] GPR3 ARRB1 [activation] JAM3 ITGAX [activation] VCAM1 IPO7 [activation] SMAD2 HIPK2 [activation] GCN1L1 PHLDA3 [activation] MDM2 VAPB [activation] NTRK2 KIDINS220 [activation] APH1B PSEN2 [activation] FKBPL IRS4 [activation] TLR7 GRAMD1A [activation] TNRC6C PAN3 [activation] NOC3L SRPK3 [activation] A2M ADAMTS1 [inhibition] MAGEA6 EIF2B5 [activation] ADM MME [activation] NUMBL APP [inhibition] TTC1 MOS [inhibition] VCAM1 RAN [activation] GSTK1 CMSS1 [activation] SH3BP1 HCK [activation] STX4 SNAP23 [activation] CHRD SMAD3 [inhibition] GABARAPL1 DOK1 [activation] JAK2 SH2B1 [activation] ESR1 PRMT1 [activation] LYN BTK [activation] TGFBI A2M [inhibition] FADD RAP1A [activation] COMMD1 SPP1 [activation] HCK CSF2RB [activation] MAPK14 PTPN7 [activation] IFNA5 APP [activation] VAPA VAPB [activation] ATP9A ESR1 [activation] EGFR DNAJC4 [activation] OGT NUP62CL [activation] ERBB3 VAV3 [activation] CDKN1C RB1 [inhibition] PIK3R1 CD7 [activation] SNCA GSK3B [activation] IRAK3 CD14 [inhibition] FYB BCAR1 [activation] TEK ANGPTL1 [activation] EIF1B EIF4H [activation] STK39 PRKCQ [activation] WRAP73 MARS [activation] OBSL1 EP400 [activation] IL12A EBI3 [activation] GSK3B RNF219 [inhibition] 页 346 共 454


2016/4/8 19:14

RTEL1 RPA1 [activation] SKAP1 LYN [activation] RRAGC RRAGD [activation] DEK CREBBP [activation] RPS26P11 EGFR [activation] NMNAT1 NTRK2 [activation] ICAM2 EZR [activation] JUNB SUMO1 [activation] GPR37L1 PRCP [activation] NR1H3 APP [activation] BOC CTNNB1 [activation] APP A2M [inhibition] TOLLIP TGFBR1 [activation] MAVS IRF5 [activation] PDPK1 SOCS3 [activation] MYL9 PRKAA1 [inhibition] S1PR3 HTR1A [activation] EGFR EIF4G2 [activation] HAVCR1 SEMA4A [activation] LEF1 NRAS [activation] NFKB1 STAT3 [activation] CD27 TRAF3 [activation] TWF2 VRK3 [activation] TFRC ESR1 [activation] IGF2BP1 GABARAPL2 [activation] DDX58 IKBKG [activation] PLCG2 JAK1 [activation] SMAD4 MEF2A [activation] CHRM2 GRK5 [activation] ATP7B ATOX1 [activation] DVL2 ARHGEF39 [activation] MAST2 TRAF2 [activation] CCNE1 CDK4 [activation] SNAI2 HDAC2 [inhibition] STAT3 MAP3K13 [activation] PPP2CA PPP1CA [inhibition] SIRT6 RAD50 [activation] NSA2 IRAK3 [inhibition] HSPA1A MOS [inhibition] RALB PLCD1 [activation] RAD21 RPA2 [activation] SNAP23 STX1A [activation] MAGEH1 ELN [activation] PRNP SURF2 [activation] FYN LCP2 [activation] RFC4 PAXIP1 [activation] GNAI3 SUMO2 [activation;inhibition] TNFRSF8 BCL6 [activation] GADD45G PLEKHM1 [activation] PSEN1 CASP1 [activation] LGR4 KMT2A [activation] ATM POLR2A [activation] ESR1 SUV39H1 [activation] CRK FRS2 [activation] TRADD DAPK1 [activation] IKBKB MEOX2 [activation] GRB10 MAPK1 [activation] PLEKHA7 YWHAB [activation] KRT18 CASP3 [activation] YAP1 LIN7C [inhibition] LRRK2 ABL2 [activation] AKAP12 TP53 [activation] TIMELESS ATR [activation] PIK3R1 CKAP5 [activation] PPP2CA PPP2R4 [activation] LRP6 ATP13A2 [activation] VAV2 BRDT [activation] CELA1 PI3 [inhibition] POLD2 POLD4 [activation] HNRNPH2 SRPK2 [activation] LPA CELA1 [activation] HSP90AA1 RHOBTB1 [activation] PTH1R CTNNB1 [activation] MAP2K3 PPP2R4 [activation] POLD1 CDK4 [activation] CUL7 ANXA5 [activation] 页 347 共 454


UBE2E3 SUMO3 CDKN1C RFC4 DIAPH2 TAB1 BRK1 ENOX1 PPP2R1A RPA1 SETDB1 CNKSR1 GATA4 CCDC28A NDC80 CR1 ARRB2 TCEB1 HCK GDF11 TFRC SRPRB PARD3 CRKL APP PRKAA1 H2AFX LIFR DNAH9 PAX6 ZMYM3 PIN1 SMARCA2 ANXA2 GPHA2 SRPK1 RANBP1 DDX5 ITCH SMO YY1 LRRK2 AURKB MAPK14 CDK17 ANGPTL3 RPAP3 YWHAB NUCB2 RAG2 HEATR2 ARRB2 FER CDC20 APP GRB2 AKT1 NXF1 EGFR YWHAE PRKACA RAC1 RCC1 ILK CD151 ATF2 PTPRJ REL AURKB AFF1 ROBO2 SHANK2 CSNK1D IL2RG OSGIN1 RPS6KA6

2016/4/8 19:14

RMND5B [activation] ATF4 [activation] PCNA [inhibition] TP53 [activation] APBB1 [activation] BIRC3 [activation;inhibition] PCDH8 [activation] TRIM43 [activation] SMURF1 [inhibition] ZNF598 [activation] MPHOSPH8 [activation] PIN1 [activation] JARID2 [activation] MYOG [activation] BUB1B [inhibition] C4A [inhibition] BOLA2 [inhibition] EFNB3 [activation] PIK3R1 [activation] WFIKKN2 [activation] VCAM1 [activation] CASP4 [activation] YWHAH [activation] ABI1 [activation] RASA3 [activation] USP2 [inhibition] ERO1L [activation] POU2F1 [activation] BCL6 [activation] PROX1 [activation] CDK6 [inhibition] CDC27 [activation] CCNE1 [activation] APOH [activation] GPHB5 [activation] RBM23 [activation] HLA-B [activation] YWHAZ [activation] SFN [activation] ARRB2 [inhibition] TWIST1 [activation] DBN1 [activation] BUB1B [activation] FLNA [activation] YWHAB [activation] ITGA5 [activation] LRCH2 [activation] WEE1 [activation] CASP7 [activation] IPO5 [activation] DNAI2 [inhibition] MAP3K7 [activation] CTTN [activation;inhibition] E2F1 [inhibition] MAST2 [activation] PHC2 [activation] PDHB [activation] ZNFX1 [activation] ANKS1B [activation] HIST1H4A [activation] CDK16 [activation] ARHGAP44 [activation] MDM2 [activation] NUP205 [activation] MMP7 [activation] YWHAB [activation] WAS [activation] BID [activation] TGFBR1 [activation] HIST3H3 [activation] RPS6KA5 [activation] PIK3R1 [activation] MCC [activation] STK4 [activation] XRCC3 [activation] RBPJ [activation] 页 348 共 454


2016/4/8 19:14

FBXO6 SERPINB1 [inhibition] ERO1LB UBC [activation] NAPA STX7 [activation] PYGM DNM2 [activation] GRB2 WDR44 [activation] HIST2H2AC TSSK6 [activation] PPP1CC LATS1 [inhibition] VCAM1 CFL1 [activation] TRAF6 BUB3 [activation] BRCA1 EP300 [activation] LTK PLCG1 [activation] TG HSP90B1 [activation] DEFA1 GSK3B [inhibition] CD79B LYN [activation] NOTCH2NL LCE2D [activation] PSEN2 RHEB [activation] RAD50 FBXO6 [activation] NFATC2 EP300 [activation] PLCG2 KIT [activation] RAG2 RAG1 [activation] ATP4A STX3 [activation] RAC1 CAV1 [activation] C1orf123 ANXA1 [activation] PPP2R1A DAPK1 [inhibition] HELZ SMYD3 [activation] EPB41 RAB5C [activation] PPP2R1A NOTCH1 [activation] NOTCH2NL KLHL38 [activation] NCK1 EIF2S2 [activation] DCC EIF4E3 [inhibition] RAD21 EIF2S1 [activation] PTPRB GAB1 [activation] SPTAN1 GRIA2 [activation] JAK3 TYK2 [activation] BMPR1B USP45 [activation;inhibition] ACTG1 GZMK [activation] PTPRO INSR [activation] TRAF2 VWA2 [activation] EXOC1 MACF1 [activation] BUB1B SNCG [inhibition] HSPB1 PNISR [activation] SFN SIPA1L3 [activation] SMAD2 FHL2 [inhibition] MEF2A CDK5 [activation] EZH2 CIT [activation] KLHL1 HSP90AB1 [activation] TP53 PLOD3 [activation] AAK1 APP [activation] FGB FGG [activation] ILK CCT7 [activation] TBL3 NUDC [activation] RPTOR PRR5L [activation;inhibition] EIF3J CASP3 [activation] COL4A4 KLK6 [activation] ECSIT PI4K2A [activation] MAP3K7 PPM1L [activation] MMP16 KISS1 [activation] SSH1 ELAVL1 [activation] CAMK2A ATP2A2 [activation] RAP2B RAPGEF2 [activation] RHOG FBXO6 [activation] GRN NLK [activation] TRPC3 GNA11 [activation] JAK2 LYN [activation] TP53 TRMT10C [activation] MAPK8 NUP98 [activation] HIPK2 MKNK1 [activation] ANXA2 HLA-B [activation] RAC1 ANGPTL4 [activation] PYCARD PYDC2 [inhibition] NUAK1 CASP6 [activation] FMNL1 CORO1C [activation] TRADD TNFRSF10B [activation] SMAD2 FOS [activation] KRT31 SHC3 [activation] MAGED1 PCK1 [activation] 页 349 共 454


2016/4/8 19:14

PPP2CA SETBP1 [inhibition] BAD BAX [inhibition] RPS6KB1 MDM2 [activation] SPEF2 IGHA1 [activation] COPS7A TP53 [activation] VCL C19orf57 [activation] GABARAPL2 RANBP2 [activation] TIPIN TIMELESS [activation] UTS2 UTS2R [activation;inhibition] RAB7L1 GAK [inhibition] GADD45B MAP2K7 [activation] HSPB1 GTSF1 [activation] ANAPC1 SOX2 [activation] SMAD3 SREBF2 [activation] MAP1LC3B TP53 [activation] HDAC1 ESR1 [activation] GDI1 HLA-B [activation] CLOCK KAT2B [activation] PACSIN1 CYFIP2 [activation;inhibition] PHB TP53 [activation] YWHAG CAMKK1 [activation] BMP7 KRTAP10-8 [activation] RIPK2 KDM3A [activation] ELAVL1 GRB2 [activation] ECT2 GRB2 [activation] CRKL RAF1 [activation] BLK EEF2 [activation] UBE2N VCAM1 [activation] GPR25 MAP3K7 [activation] CDC27 CCND1 [activation] BEND5 DDR1 [activation] SNCA TUBA1A [activation] EIF3D GRB2 [activation] MAPK6 MDK [activation] FOSL1 CREBBP [activation] ATR HSPA4 [activation] VCAM1 YTHDF2 [activation] TP53 MAGED2 [activation] NGFR PIAS2 [activation] HSPB1 DMWD [inhibition] KDELR1 WBP5 [activation] HSP90AA1 IRAK3 [inhibition] HIST3H3 TNFRSF1A [activation] APC TMEFF1 [inhibition] KANSL1 TRAF2 [activation] CCDC8 F11R [activation] MAPT CDK5R1 [activation] APEX1 ARF6 [activation] ILK HNRNPL [activation] SUPT20H HIST3H3 [activation] GRB2 TCEAL8 [activation] JUP ZFYVE9 [activation] TRAF6 YES1 [activation] CCNB2 MCM2 [activation] CREBBP MDM2 [activation] RBL1 CCNA1 [activation;inhibition] HIPK2 MBP [activation] CDK19 AZGP1 [activation] MAP2K1 CPNE4 [activation] RPS6KA5 ITSN1 [activation] HRAS RASIP1 [activation] RGS20 INS [activation] ESR1 VPS13D [activation] HIST2H3A ICAM1 [activation] CD81 TUBA8 [activation] OBSL1 CAMKK2 [activation] MOV10 ACACA [activation;inhibition] TRAF6 IL17RA [activation] RAP1B RGL2 [activation] MYC MYO5C [activation] NUMB EPS15 [activation] TXK KIT [activation] BCR DOK1 [activation] XRCC3 FANCG [activation] CLDN3 CTSS [activation] IRS4 HSPB1 [activation] 页 350 共 454


PRKCD HSPD1 PRKCB WDFY3 SNAP29 ARL8B SMARCB1 KHDRBS1 MDM2 RIMS2 LAMB2 IQCB1 GAPDH ZNF83 FES MAD2L1 PPP2R1A RAB5C NCAPH NLRP4 PAX6 UBE2I PRKCDBP STAT5A LCK EXTL3 CDKN1A MDM2 PBX3 RAD52 WAS CYCS GBF1 MAPT MAP3K8 STX4 HSPB1 PAK2 SFN PPM1B DIMT1 SNRNP70 BARD1 CDC23 CDK5 RAB22A SGTA ARRB2 ANXA7 FBXO6 VCAM1 NLRC5 TRAF6 MRVI1 ARF6 CDC16 ANAPC1 TLR3 NFAT5 HMGB1 CAP1 TBC1D15 PCNA PML PPM1G PRKCA AVP NCOR2 LYN TLK1 YWHAZ SRPK1 TRAF6 FYN PARD6A EGFR

2016/4/8 19:14

HSP90AA1 [activation] TP53 [activation] RIPK4 [activation] ATG5 [activation] ATF4 [activation] APP [activation] GABARAP [activation] CRKL [activation] EIF4A1 [activation] GRB2 [activation] KPNA2 [activation] HSPA6 [inhibition] MAPK7 [activation] PAK1 [activation] EZR [activation] TP73 [activation] VCAM1 [activation] NXF1 [activation] SMC4 [activation] NLRC4 [activation] EN1 [activation] PRKDC [activation] MRFAP1L1 [activation;inhibition] CTLA4 [activation] PECAM1 [activation] GRB2 [activation] FKBPL [activation;inhibition] PFN1 [activation] ZNHIT3 [activation] RPA1 [activation] ITSN1 [activation] IKBKE [inhibition] PTP4A3 [inhibition] LIMS1 [activation] RELA [activation] STXBP6 [activation] YWHAQ [activation] CASP7 [activation] KIAA0408 [activation] FOS [activation] ITGA4 [activation] RELA [activation] GIT1 [activation] CDC5L [activation] SRC [activation] APPL1 [activation] REC8 [activation] IGKC [activation] GABARAPL1 [activation] PLOD2 [activation] RPS28 [activation] CHUK [activation] TXN [activation] MME [activation] MEPCE [activation] FBXO5 [activation] CDC20 [activation] TOLLIP [activation] PTPN6 [activation;inhibition] POU5F1 [activation] ATF2 [activation] RAB5C [activation] LIG1 [activation] MYB [activation] HIST3H3 [activation] RGS2 [activation] AVPR2 [activation] CHUK [activation] BANK1 [activation;inhibition] CHEK1 [activation;inhibition] SHC1 [activation] USP39 [activation] RPA3 [activation] PRKCQ [activation] SMURF1 [inhibition] CALM1 [activation] 页 351 共 454


2016/4/8 19:14

S100A7 EGFR [activation] ETS1 NCOR1 [activation] BAK1 KRT31 [activation;inhibition] EIF2S3 EIF2S1 [activation] SFN BCAR1 [activation] RNF114 TRAF6 [activation] SH2D1A ARHGEF7 [activation] YWHAZ HNRNPL [activation] PTEN IRS4 [activation] GIMAP8 LRRK2 [activation] CD4 HNRNPA1 [activation] AHCYL1 ITPR1 [inhibition] CREBBP CRX [activation] VEGFA SEMA3F [activation] TRPV6 PRKCA [activation] MSH5 MSH4 [inhibition] CCND3 PPP1CC [inhibition] CCDC57 CDC20B [activation] LIN9 NXF1 [activation] NR1H3 NCOA3 [activation] DOK2 EPO [activation] ARHGEF4 RAC1 [activation] RXRA NCOR2 [inhibition] RAC1 TNFAIP8L2 [activation] RORC PPP2CA [inhibition] POLR2A GTF2A2 [activation] ARRB2 CTTN [inhibition] CFTR STX1A [activation] STAU1 ARPC4 [activation] EIF5 CSNK2B [activation] NCKAP1 ABI1 [inhibition] MYC DIRAS2 [activation] CLNK EGFR [activation] RAF1 PAK3 [activation] TF IGKC [activation] AMT HSPA8 [activation] SHD MET [activation;inhibition] PFN2 SNTA1 [activation] MET PASK [activation] PIK3R1 CXCL2 [activation] PTPRC ZAP70 [activation] EZH2 RPS6KA5 [activation] ZNHIT1 TP53 [activation] HDAC6 MAPT [activation] YBEY EGFR [activation] CCDC33 TRAF2 [activation] NUP98 NUP62 [activation] MYC IPO7 [activation] STX1A SNAP29 [activation] HLA-B DIABLO [activation] YWHAH HSPA8 [inhibition] PTPN23 EGFR [activation] PARD6G YWHAE [activation] HSP90AB1 TRIM73 [activation] ITGB2 DOK1 [activation] TGIF1 HMGB1 [inhibition] TNFRSF1A GRN [activation] APP AIFM3 [activation] PRIM2 SUV39H1 [activation] DIAPH1 CLIP1 [activation] CAMKK2 HSP90AA1 [activation] RCC1 CDK1 [activation] MS4A1 IGHM [activation] ACTG1 ACTB [activation] RPA3 SLFN11 [activation] HDAC1 HSF1 [activation] ANAPC7 SOX2 [activation] TFE3 TFEB [activation] IRAK1 VASP [activation;inhibition] PIK3CA TNFRSF1A [activation] NANS STK11 [activation] RHOBTB2 STK11 [activation] MIF CFLAR [activation] LYN PILRB [activation] MAPT PPP2CB [activation] CASP1 PLA2G4A [activation] 页 352 共 454


2016/4/8 19:14

CRMP1 IL33 [activation] RNF41 C1orf109 [activation] CAMK2A ZMYM1 [activation] BCL6 TRIB3 [activation] MBP CTDSP1 [activation] PTPLAD1 CASP4 [activation] PYY NPY1R [activation] CRK PCDHA5 [activation] MAP4K4 PRKCE [activation] FAS ANK3 [inhibition] USP38 HSPB1 [inhibition] FYN VPS13A [activation] NAT2 CDH1 [activation] ERBB4 NCK2 [activation] RAD51 RAD51C [activation] CASP6 TAB1 [activation] NOP2 GABARAPL2 [activation] DAPK1 KRIT1 [activation] PPARG CIITA [activation] HMGB1 RB1 [inhibition] RAB11A TBC1D14 [activation] MMP24 KISS1 [activation] CISD1 NR4A2 [activation] VCAM1 ASNS [activation] FBXW7 CSF3R [activation] DYSF FLNC [activation] RARA STAT1 [activation] PELI3 IRAK1 [activation;inhibition] RAB5C TBC1D17 [activation] TACC2 FTSJ1 [activation] CDC37 MAPK7 [activation] SMAD3 LEF1 [inhibition] DLGAP4 PLK2 [activation] STAT5B ETS1 [activation] ARHGDIG CEP170P1 [activation] C1orf109 USHBP1 [activation] ZNF408 MIF [activation] RIN1 EGFR [activation] EVI5L RAB10 [activation] RASA1 STK11 [activation] PAX6 SMARCA4 [activation] SERPINA5 FGA [inhibition] NR1D1 NR2E3 [inhibition] DDX24 IDO1 [activation] MYB CLTC [activation] OBSL1 EIF4A3 [activation] SLC8A1 CAV3 [inhibition] HEATR2 ILK [activation] CDKN2A ACTG1 [activation] CAV1 ADRBK1 [activation] NCK1 NOTCH3 [activation] EPHA3 STAT3 [activation] ARRB2 PPIA [inhibition] KATNB1 TGFBR1 [activation] TMEM184C SGK1 [activation] PYCRL TP53 [activation] TLR2 CXCR4 [activation] PPP1CC HSPA4 [inhibition] TRHDE AKT1 [activation] KRCC1 PPP1CC [inhibition] CDKN2A HIST3H2BB [activation;inhibition] PML FOS [activation] HSPA8 ARRB2 [inhibition] H2AFX MAPK8 [activation] GSK3B NRBP1 [activation] MORN4 BEND3 [activation] PTK6 FCHO1 [activation] RASA1 APC [activation] KAT2B HIST1H2AB [activation] TRADD CALM1 [activation] RAB5A TBC1D15 [activation] TAGLN CFL1 [activation;inhibition] SERTAD1 PPP2R1A [inhibition] VCAM1 ITGA5 [activation] RASGRP3 SULT1C2 [activation] DAPK1 PKM [activation] 页 353 共 454


2016/4/8 19:14

SH2B2 SYK [activation] SRMS HSPB1 [activation] CDK3 E2F1 [activation] SERPINF2 TGM2 [activation] GTF2H2 CCNH [activation] PTGES3 DNAJB1 [inhibition] CHN1 GTF3C1 [activation] IRF3 TRAF3 [activation] NEDD4 SMO [inhibition] S100A10 ANXA2 [activation] TRIP13 PPP2CA [inhibition] BCL6 HSP90AA1 [activation] GRIPAP1 SPP1 [activation] GNB2 ESR1 [activation] FOS ARL6IP4 [activation] RPS6KB1 EIF4E [activation] HIST1H3A PRKCA [activation] CALM1 SYK [activation] ATF2 ANXA1 [activation] CCL2 MMP8 [activation] BID GBP2 [activation] PRKACA MAP2 [activation] COLQ MUSK [activation] PTEN TTBK2 [activation] RIPK1 TNFRSF10A [activation] H2AFX BRD1 [activation] CAPZB MDM2 [activation] GRIN2A PTK2B [activation] NTRK2 EGFR [activation] TXNDC17 CFL1 [activation;inhibition] TP53 ECD [activation] SMARCE1 NUP62 [activation] AOX1 CRKL [activation] KAT2B JDP2 [activation] KCNA3 BAX [activation] IKBKG MYD88 [activation] VCAM1 APOE [activation] SMYD2 AXIN1 [activation] C17orf82 TRAF2 [activation] C5AR1 RPS19 [activation] PARD3 ARPC2 [activation] KPNB1 SREBF2 [activation] PRIMPOL SMARCAL1 [activation] PPP1CC RB1 [inhibition] ITGA4 ATXN2L [activation] RASL12 SMAD3 [activation] TES TLN1 [activation] SGK1 NASP [activation] KMT2A ASH2L [activation] C6orf165 ROCK1 [activation] H2AFZ SMC2 [activation] CCNH ERCC2 [activation] HSPA1L GABARAPL2 [activation] NFATC2 PPP2R1A [activation] TP53 PPA1 [activation] SHB LAT [activation] MAPK10 MAPK9 [activation] BARD1 RFC2 [activation] ANAPC4 TP53BP1 [activation] ITGB1 RPA2 [activation] SEMA4C FBXO6 [activation] WWTR1 DDX17 [activation] RAB14 RAB11FIP1 [activation] MYC ITGAL [activation] CAPN1 VCAM1 [activation] NAP1L5 GRB2 [activation] KLHDC7B NUDCD3 [activation] LPL UBE2Z [activation] GATA4 NR5A1 [activation] GRK6 HSP90AB1 [activation] PPP1R16A LY6H [activation] CAP2 ACTG1 [activation] MYOC NOTCH2 [activation] UBE2F EIF2B4 [activation] RAF1 RHEB [activation] NFASC GRB2 [activation] 页 354 共 454


2016/4/8 19:14

RAB5B CDK1 [activation] PPP4R1 HDAC3 [activation] BPIFB3 STAT1 [activation] FAM84B RAD51 [activation] NOS1 CAMK1 [activation] NR3C1 HOXB1 [activation] PLG F3 [activation] F2R CAV1 [activation] SP1 MYCN [activation] GPR25 VAPB [activation] SRPK1 WDR1 [activation] MDC1 ANAPC10 [activation] ANXA5 ITGB5 [activation] RAB3D AKT2 [activation] ZNF823 PAK1 [activation] RPA1 RPA3 [activation] SRPK1 HECW2 [activation] MME METTL7A [activation] NXF1 TIFA [activation] MYL3 ATG101 [inhibition] STX1A TXLNA [activation] USP9X MTOR [activation] HLA-B PREP [activation] KCNA3 KCNA1 [activation] DDX5 SMARCA4 [activation] VARS SGK1 [activation;inhibition] YWHAZ SH3BP5L [activation] SFN ARHGEF17 [activation] CEBPA RBL1 [activation;inhibition] APPL1 DPYSL5 [activation] RAB5A GRIK4 [activation] SNIP1 MAX [inhibition] ILK COPB2 [activation] GRWD1 TP53 [activation] ACTG1 MYO1A [activation] TNFRSF14 IMPA2 [activation] SMAD3 LCK [activation] HNRNPA0 SMURF1 [inhibition] PRKAA2 PARS2 [inhibition] NOTCH2NL CXCL5 [activation] ELK1 STK16 [activation] GSTK1 EIF4G2 [activation] MTOR GSK3B [activation;inhibition] ADRB2 RANBP2 [activation] LYAR FGF18 [activation] LYZ IKBKB [activation] PRMT5 SMARCB1 [activation] SMAD5 DDX5 [activation] LYN ABI1 [activation] MDC1 MDM2 [activation] STK4 AKT1 [activation] CALM1 CNN1 [activation] RPL7 RAN [activation] ACVR2B HSP90AA1 [activation] MAP4K4 MINK1 [activation] CSF1 SLA2 [activation] CD4 DHRS2 [activation] CASP9 MSTO1 [activation] NDUFA4 ILK [activation] UPF2 WNK1 [activation] WDR16 HSPA1A [inhibition] C9orf78 TAB1 [inhibition] MAPK9 MAP3K1 [activation] NOS3 PPP2R5A [activation] SYCP3 REC8 [activation] UBA5 LTA4H [activation] DLX5 MSX1 [activation] SMURF1 DUSP13 [inhibition] ELAVL1 RICTOR [activation] ITK CD2 [activation] YWHAZ STK38 [activation] RPS6KA1 GMFB [activation] TP53 IQGAP1 [activation] CRYAA HSPB1 [activation] CDH1 ADAM9 [activation] NFATC3 CDK6 [inhibition] 页 355 共 454


2016/4/8 19:14

ANXA2 ARRB2 [activation] RAPGEF2 FLNC [activation] PPP2R2A GRB2 [activation] SYNGAP1 CAMK2A [activation] PRKCA ADAP1 [activation] YWHAB H2AFX [activation] CKAP4 TP53 [activation] BRCA2 FANCG [activation] SRPK1 KCNAB1 [activation] NR3C1 POU2F1 [activation] TRAF6 PPP1CC [activation] PAXIP1 DDX52 [activation] NOD1 HSP90AA1 [activation] ERBB4 YAP1 [activation] CHEK1 BTG3 [activation;inhibition] ESR1 TRAF6 [activation] AMOT AMOTL1 [activation] CASP7 COPS6 [activation] MAPK9 DUSP1 [activation] CRY1 CSNK1E [activation] XIAP CASP4 [activation] DNAJB1 AKT1 [inhibition] CDK3 EIF2AK2 [activation] RAB4A PRKCI [activation] RAN PPP2R2B [activation] HSPH1 PAFAH1B1 [activation] SRF HDAC4 [activation] TRAF2 TNFRSF18 [activation] YWHAG ATF2 [activation] DEFB103A CCR6 [activation] VCAM1 ITGB7 [activation] RICTOR RPL23 [activation] EIF4EBP1 ATM [activation] FZR1 MYC [inhibition] FOS BATF [activation] PPP1CA ZFYVE16 [activation] TFF2 FCRL4 [activation] SYP VAMP2 [activation] ITGB1 LYN [activation] SUV39H2 NCK1 [activation] IRF7 TICAM1 [activation] HSPA1A BRSK1 [inhibition] BRCA2 CDK2 [activation] LY96 TLR2 [activation] YWHAZ TH [activation] LAMA5 COL7A1 [activation;inhibition] HSP90AB1 DDX24 [activation] IER3IP1 TRAF6 [activation] EP300 MYB [activation] TP53 RNF39 [activation] CRK MAP4K5 [activation] CHUK RPL27 [activation] FTSJ1 ZMPSTE24 [activation] JUND FOS [activation] TP73 MYC [activation;inhibition] GRB2 ARHGAP17 [activation] UBE2U BARD1 [activation] GRIP1 GRIA4 [activation] DDX4 SRC [activation] CAMK2D MOAP1 [activation] LPL COPS6 [activation] RHOA CNKSR1 [activation] GNL3L TP53 [activation] GIPC1 RGS1 [activation;inhibition] OBSL1 GSN [activation] ITGA4 ACTG1 [activation] MCM7 SUV420H2 [activation] DRD2 GNAI2 [activation] ARRB1 DVL2 [activation] MRFAP1L1 CAGE1 [activation] NUP62 G3BP2 [activation] YY1 BCL6 [activation] PIK3R3 FBN3 [activation] HSP90AB1 MAP3K8 [activation] HDAC3 MEF2A [activation] MAP2K7 TRIB3 [activation] 页 356 共 454


2016/4/8 19:14

RPA2 EIF2S2 [activation] TAGLN2 ITGA4 [activation] MTOR LRPAP1 [inhibition] CSNK2A1 MYC [activation] STAT5A INSR [activation] SMAD1 NEDD9 [activation] CAB39 STK11 [activation] CSNK2B VCAM1 [activation] SUPT16H ICAM1 [activation] PIK3R1 IL7R [activation] BLNK MAP4K1 [activation] ACTB BCL7C [activation] SRPK1 CHERP [activation] TIMM50 TP53 [activation] METTL21A HSPH1 [activation] TP53 HDAC1 [activation] JAKMIP2 KIF9 [activation] CD5 LCK [activation] CTNNA2 EGFR [activation] SREBF2 INSIG2 [activation] KDR EPN1 [activation] KDM6A KMT2D [activation] SDC4 TIAM1 [activation] KIT RFC1 [activation] CSRP2 STK4 [activation] SUCLG2 MYC [activation] HLA-C B2M [activation] ITGA2B CD36 [activation] WDR36 TBXA2R [inhibition] SLC9A3R1 EGFR [activation] PHLDA3 RFXANK [activation] VAMP2 TRPC3 [activation] ABCE1 ITGA4 [activation] RAC1 DEF6 [activation] LSP1 MAPKAPK2 [activation] SMARCA5 PTBP3 [activation] MYB TRAF6 [activation] SLC9A3R1 SLC9A3 [activation] LAT CD3E [activation] MTUS2 PRKAA1 [inhibition] SMURF1 MAVS [inhibition] MCAT ICT1 [activation] ANKRD36BP1 USHBP1 [activation] MAPRE1 NUPR1 [activation] S1PR1 SP1 [activation] IGF1R FFAR2 [activation] SAMD9 EEA1 [activation] PRKCD NCF1 [activation] JUN MAP2K4 [activation] HSP90AB1 ERBB3 [activation] RPS14 GRB2 [activation] BID CSNK2A2 [activation] DDX39A MDM2 [activation] MDM2 RASSF3 [activation] CTNNB1 YAP1 [activation] NBN TCOF1 [activation] EHMT1 RELA [activation] AURKB AMOT [activation] PLCD1 PAXIP1 [activation] CAST GRB2 [activation] SRPK2 PPIL1 [activation] STK4 IQGAP1 [activation] GRB2 SERBP1 [activation] HLA-B KPNA3 [activation] CDK1 RACGAP1 [activation] YTHDF1 RPA3 [activation] IFNG TNF [activation] ANAPC5 MAPK6 [activation] CDK18 CTSB [activation] MAPK14 BMI1 [activation] APC KIAA1328 [inhibition] TNFRSF14 HDAC4 [activation] CRTC1 CREBBP [activation] A2M MAPK6 [inhibition] BAD GRB2 [activation;inhibition] ATF4 EP300 [activation] 页 357 共 454


2016/4/8 19:14

CUTC BCL6 [activation] MAPK14 DYRK1B [activation] RAD51 ABL1 [activation] BCL2L1 RTN4 [activation] EFNB1 TIAM1 [activation] LRP6 PDGFRB [activation] CCNG1 KRT40 [activation] DAB2IP SKP1 [inhibition] PRKAB1 EIF2S3 [activation] SERTAD1 HSPB1 [activation] FAF2 HIF1A [activation] CRK EXTL3 [activation] PIK3R1 TPSAB1 [activation] CACNG3 APP [activation] MAPK1 CREBBP [activation] YWHAZ TP53BP1 [activation] BTG1 CCNA2 [activation] NOS3 MAGEA11 [activation] CA4 PIH1D1 [activation] EP300 ILF2 [activation] TUB ABL1 [activation] SERTAD1 CCND2 [inhibition] DLG2 WNT3A [activation] LTBP2 FYN [activation] GNAS SMAD2 [activation] TP53 EHMT2 [activation] TGFB1I1 GIT2 [activation] MCM4 ITGA4 [activation] CASP8 PSEN1 [activation] KIAA0408 TRAF2 [activation] MLH1 C9orf156 [activation] TP53 WT1 [activation] SRPK1 RBMS2 [activation] RPAP2 GPN3 [activation] HSP90AB1 LATS1 [activation] EIF3A RPTOR [activation] ICAM1 EIF3I [activation] PEBP1 CDK2 [inhibition] ZBTB16 EIF2S2 [activation] NR1I2 RXRB [inhibition] IKBKB HSP90AB1 [activation] SRC GUCY2C [activation] SWSAP1 RAD51C [activation] UBTF CREBBP [activation] NXF1 FUNDC2 [activation] CREBBP TP73 [activation;inhibition] ATP6AP2 REN [activation] SETDB1 EHMT1 [activation] RELA DDX21 [activation] TNFRSF14 LHPP [activation] PTK2B PDCD6IP [activation] BBS10 TNFSF11 [activation] GSTM3 GH1 [inhibition] ILK LIMS2 [activation] DNAJB1 NRAS [inhibition] TNIP2 NFKB2 [activation] L1CAM MSN [activation] CD79A IGJ [activation] LST1 PRKCB [activation] LNP1 LYN [activation] LRRK2 ARHGEF7 [activation] CTNNB1 ERMN [activation] HSP90AB1 EIF2AK1 [activation] FOXO1 ESR1 [activation] MYC NCAPD3 [activation] LINC00526 NOTCH2NL [activation] CERS2 EGFR [activation] HSPA5 A2M [inhibition] SMARCC2 GRB2 [activation] MEMO1 VCAM1 [activation] TBC1D2 BUB1 [activation] FHL2 MCM7 [activation] CDH13 MAPK6 [activation] PRKCD APP [activation] AURKA CDH13 [activation] NOV IGF1 [activation] 页 358 共 454


2016/4/8 19:15

MAPK3 MAPK8 [activation] FKBPL GNAZ [activation] STAT5A PRTFDC1 [activation] RABAC1 SNCA [activation] STK4 HSPA9 [activation] RAB5C HLA-B [activation] CUZD1 PTPN6 [activation;inhibition] MARK2 MAPT [activation] TOP1 WHSC1 [activation] GNAI1 S1PR2 [activation] DDX18 PAXIP1 [activation] MLH1 ANXA6 [activation] GRIA2 SDCBP [activation] TNFAIP6 THBS1 [activation] GNB1 ATXN10 [activation] SRPK2 LUC7L2 [activation] MST4 PPP2R4 [activation] DOCK7 ANXA7 [activation] ACTR2 TNIK [activation] CDK17 EPHA2 [activation] HCK DIAPH1 [activation] IL2RG CAPNS1 [activation] TBKBP1 OBSL1 [inhibition] RAN BIRC5 [activation] MAPK3 FPR1 [activation] IRAK4 MBP [inhibition] FGFR4 CDH2 [activation] VAV1 RAF1 [activation] EIF4EBP1 RICTOR [activation] CCDC8 SMARCA5 [inhibition] RSRC2 SRPK2 [activation] RELA IKBKG [activation] RPS6KA2 CREB1 [activation] AR RNASEL [activation] WHSC1 DDX54 [activation] ZBED2 POT1 [activation] CDH1 MAP2K1 [activation] TP53BP1 RPA1 [activation] SRC PTGER4 [activation] ANAPC11 ANAPC2 [activation] GABARAPL2 SMARCA4 [activation] MAPT APOE [activation] BCL2L1 UHRF2 [activation] TSPYL4 TP53 [activation] PRTN3 F2RL1 [activation] ICT1 AFG3L2 [activation] HSPA1A APAF1 [activation] STK39 CD46 [inhibition] SAAL1 CA9 [activation] RPL41 MAPK14 [activation] BBC3 BAX [inhibition] EP300 NFKB1 [activation] CASP7 ARHGDIA [activation] NKX2-1 MAPK1 [activation] MYOM2 TAF1 [activation] DNAJB5 TTN [inhibition] CCL5 KRAS [activation] MCM5 MCM3 [activation] ACTN1 TES [activation] CD44 ACTR3 [activation] CBLB IRS1 [inhibition] GNB1 RICTOR [activation] TGFBR1 PARD6A [activation] CRY2 NXF1 [activation] PLSCR1 RASD1 [activation] TDGF1 GDF9 [activation] EIF2AK2 GABARAPL2 [activation] PIK3R1 AGAP2 [activation] ASAP1 PTK2B [activation] PPP1R2 MYC [activation] EEPD1 EPHB2 [activation] MAGEC2 UBE2H [activation] CTBP2 FOXP2 [activation] PLCD1 CALM1 [activation] ESR1 BAZ1B [activation] NXF1 STX2 [activation] 页 359 共 454


2016/4/8 19:15

REPS1 ATF4 [activation] ABL1 SPAG9 [inhibition] HSP90AA1 MYLK3 [activation] RAB5A TXNIP [activation] SMARCC1 CREBBP [activation] PIK3R1 PLCG1 [activation] TRAF6 RANBP9 [activation] KIT SOCS5 [inhibition] RFC4 EGFR [activation] RAN UBC [activation] CCL5 CDH1 [activation] SMARCA5 AIM2 [activation] RPS6KA1 HSP90AA1 [activation] SMAD4 HERC5 [inhibition] PTPN2 PDGFRB [activation] PRKCE CNN1 [activation] GNA14 SNW1 [activation] FOS USF2 [activation] PRKCZ STAT6 [activation] SAA4 COL4A1 [activation] PMS2 CYLD [inhibition] EPAS1 DBP [activation] PRMT1 MECOM [activation] PRNP ADAM23 [activation] PPP2R1A PPFIA3 [inhibition] LRRK2 CSNK1G2 [activation] PIK3R1 YWHAG [activation] ATM ATR [activation] GRB2 YWHAZ [activation] SPTAN1 GRB2 [activation] HSPA4 TRAF6 [activation] ITCH NFE2 [activation] VASH2 LRRK2 [activation] ZAP70 MET [activation;inhibition] CTNNB1 FANCG [activation] RAB2A RGS2 [activation] MBP APP [inhibition] SRC LIG3 [activation] SRPK2 DHX15 [activation] USP9X MLLT4 [activation] TNF MMP17 [activation] PBDC1 CTNNB1 [activation] ERH EIF4A3 [activation] GPRASP1 PER1 [inhibition] THRA NSD1 [activation] PIK3R2 YWHAB [activation] ARRB2 CDC42 [activation] MYB RQCD1 [activation] SUPT6H SMAD2 [activation] PPARG VDR [activation] ITGB1 CD36 [activation] SMAD1 PIAS1 [inhibition] HNRNPUL1 EP300 [activation] IL37 IL18R1 [activation] RAP2B MME [activation] ERC1 ITSN2 [activation] PTPRO PDGFRB [activation] TRIM69 NEK8 [activation] FLNA PAK1 [activation] HMGB2 VCAM1 [activation] SMURF2 RHOA [activation] RPL37 SRPK1 [activation] PRKCD KLF5 [activation] CHD3 TP53 [activation] SH2B2 ASB6 [activation] GCG MEP1B [activation] NUP153 MAPK3 [activation] NXF1 SLC31A1 [activation] PRSS23 PDPK1 [activation] TRAF3 MYD88 [activation] DVL1 SCYL2 [activation] RAD51D HELQ [activation] SMARCA4 NOTCH1 [activation] ACTB ESR2 [activation] APP SKAP1 [activation] MAPK1 NDE1 [activation] 页 360 共 454


2016/4/8 19:15

KNDC1 MYC [activation] ZNHIT3 RXRA [inhibition] MYD88 IRF4 [activation] HLA-B RCC2 [activation] SORT1 LPL [activation] JAK2 HIST2H3A [activation] HSPA8 APP [inhibition] PAICS SGK1 [activation] P4HB ATF2 [activation] NUP214 APC [activation] MLH1 BARD1 [activation] ERCC6 HIST1H3A [activation] CASP4 CASP10 [activation] PPP6R3 GPSM1 [inhibition] ATXN7L3B EGFR [activation] SOCS4 NR4A1 [inhibition] MAPK8 MAPKAP1 [activation] TNFRSF12A RAC1 [activation] DYDC1 NME5 [activation] CTNNB1 RAPGEF2 [activation] REXO2 ATG5 [activation] EEF1D CD48 [activation] NEURL2 CTNNB1 [inhibition] CDC16 SMAD2 [activation] ARF4 ATF2 [activation] TLR9 SIGIRR [activation] ASAP2 PXN [activation] TLR9 SRC [activation] DCLRE1C PRKDC [activation] RAD51 UGDH [activation] DSC1 DSG1 [activation] TSC22D3 FOS [activation] TES NXF1 [activation] RPL29 TIMP2 [activation] SERTAD4 AKT1 [activation] YWHAE OBSL1 [activation] DAPK3 MDM2 [activation] APP C17orf85 [activation] PTRH2 MDM2 [activation] SNCA EIF3G [activation] MIF UPF2 [activation] PPP1R3A RPS6KA1 [activation] EGFR GEMIN6 [activation] FPR1 GNAI2 [activation] RAC1 VCAM1 [activation] PRKACA RSBN1 [activation] HSPB1 CCNDBP1 [activation] PTPN11 FLT3 [activation] GCN1L1 IKBKE [inhibition] DLGAP4 PIK3R1 [activation] SLC25A6 CHEK2 [activation] MMP3 TIMP3 [activation] GRB2 ACTG1 [activation] ICAM1 EIF3C [activation] ITGB1 FLT4 [activation] EGFR NTPCR [activation] PIP5K1A CASP3 [activation] CCDC8 PRKAA1 [inhibition] STRN4 CAV1 [activation] TAB2 TNFRSF11A [activation] QARS CDK4 [inhibition] GSK3B NAT9 [activation;inhibition] EGFR IDH3A [activation] TNFSF13 KRAS [activation] TRAF1 TNFRSF14 [activation] MTOR NXF1 [activation] PRIMPOL RPA3 [activation] EGFR C6orf120 [activation] MDC1 ANAPC4 [activation] NRP2 FLT1 [activation] PACSIN1 SOS1 [activation] DHH PTCH2 [activation] SRSF10 BARD1 [activation] NR3C1 EIF4A2 [activation] CD81 HIST1H1C [activation] BARD1 TRAPPC8 [activation] 页 361 共 454


2016/4/8 19:15

NME1 PRKAA1 [activation] RRAS2 RALGDS [activation] GABARAP SRSF5 [activation] EIF4E2 TRAF6 [activation] SCHIP1 SCG2 [activation] CDC7 MCM10 [activation] YAP1 YWHAB [activation] RPAP3 PARD6A [activation] TRAF3IP3 TRAF3 [activation] CFL1 ESR1 [activation] NOTCH2NL C19orf66 [activation] LATS1 LZTS2 [inhibition] E2F1 CHEK2 [activation] ARRB1 GNAQ [activation] HLA-G LILRB2 [activation] CREBBP POU2F3 [activation] CBL ITGAV [activation] YWHAB INSR [activation] LATS1 MOAP1 [inhibition] PLD2 ACTN1 [activation] RAPGEF1 GRB2 [activation] FANCD2 IPO4 [activation] CCT8 GRB2 [activation] GADD45B CDKN1A [inhibition] PSIP1 MEN1 [activation] SMAD2 RHEBL1 [activation] NUP62 AHCTF1 [activation] LAIR1 PTPN6 [activation;inhibition] OSTF1 EXT1 [activation] EIF2S1 ERG [activation] JAK2 STAP2 [activation] KPNB1 FGFR1 [activation] FTSJ1 PRMT1 [activation] SIRT3 SKP2 [activation] MEIS2 OSGIN1 [activation] ULK2 OBSL1 [inhibition] GRB2 PLD2 [activation] FYN C7orf25 [activation] RAD51 IL24 [activation] TAF1B HIST2H2AC [activation] KLHL23 NUDCD3 [activation] HPRT1 FANCA [activation] TIAM1 PRKCG [activation] MAP3K10 MLK4 [activation;inhibition] MYC SKP1 [inhibition] LRRK2 PCNA [activation] H2AFX BAZ1B [activation] SPIN1 HSPB1 [activation] PIN1 ABI2 [activation] RAC1 ARHGAP17 [activation] RBPJ NCOR1 [inhibition] MAP3K14 IL1R1 [activation;inhibition] A2M RAB3A [inhibition] NR3C2 PIAS1 [inhibition] E2F1 CDC27 [activation] ACACA IFIT1 [activation;inhibition] BCL2L11 RIOK3 [activation] PRKCD GSK3A [activation;inhibition] CHPF ARHGEF5 [activation] TRMT2A CDK4 [activation] PAX6 PBX1 [activation] NAIP CASP9 [inhibition] TRIM24 ATF4 [activation] EGR1 TBX2 [activation] RPL7 GRB2 [activation] HDAC1 SMC4 [activation] MAPT TUBA1A [activation] STK4 STRN [activation] SPP1 NACA [activation] GOSR1 EBI3 [activation] RHOQ ELAVL1 [activation] PAX6 VSX2 [activation] VAMP8 CDC25A [activation] EIF4E RPS6KA5 [activation] RYR1 PRKG1 [activation] INHBB INHBC [activation] 页 362 共 454


CPSF2 DDI1 BTRC CCNT1 RIMS2 EGFR EIF4B GNAI1 CDKN2B ESR1 EGFR PTK2B FZR1 NSD1 STRADB IL2RG PIM2 MAVS MAP2K5 ELANE CBX3 HLA-A PAK1 IL1RAP DNM1L MYC PRKCB IRS1 EZH2 DNAJC13 DLGAP4 PTK2 YWHAZ TP53 DOK1 NBN TRIM54 ERBB2 NFE2L2 EIF5 BARD1 MITF GRK6 EHMT2 ILK FZR1 NUDC HSF1 NEU3 DYRK1A HSPA4 INHBA IGF2 CD14 EPOR MAPK1 ROR1 SUMO4 MT-CO3 MYC RASSF8 MYB PCDHA8 USMG5 CEBPB SMAD2 SEMA7A DYRK1B DHRS2 PTBP1 PDPK1 GRB2 SMC4 APP GNAI2 MARK3

2016/4/8 19:15

CPSF3 [activation] KLHL42 [inhibition] DLGAP5 [activation] KMT2A [activation] FYN [activation] AP1M2 [activation] PLK1 [activation] RANGAP1 [activation] CCDC33 [activation;inhibition] HSPA4 [activation] CTTN [activation] TLN1 [activation] E2F3 [inhibition] VDR [activation] CAB39 [activation] JAK2 [activation] BAD [activation;inhibition] ABL1 [activation] PRKCZ [activation] THBS1 [activation] LRRK2 [activation] SRC [activation] SRSF2 [activation] TRAF6 [activation] LRRK2 [activation] OPHN1 [activation] HSP90AB1 [activation] SH2B1 [activation] EHMT1 [activation] RPS6KA6 [activation] SYNGAP1 [activation] NCK1 [activation] MINK1 [activation] MAD2L1BP [activation] PTK6 [activation] IPO5 [activation] CDKN1A [inhibition] TEC [activation] MAFG [activation] IKBKE [activation] TSR1 [activation] FOS [activation] EDNRB [activation] CACNA1A [activation] EWSR1 [activation] PTEN [activation] ARF6 [activation] CDK6 [activation] CAV1 [activation] MAP3K5 [activation] EPAS1 [inhibition] ENG [inhibition] CRELD2 [activation] DIP2A [activation] PTPN1 [activation] GABRR1 [activation] MORC3 [activation] HSPA8 [inhibition] RAC1 [activation] IDH3B [activation] PPP1CA [activation;inhibition] HIPK2 [activation] CRK [activation] BLK [activation] SMARCA4 [activation] GFER [activation] ABL1 [activation] CREBBP [activation] MDM2 [activation] STK4 [activation] GIT1 [activation] ARHGAP20 [activation] TRAF3IP1 [activation] EPB41L5 [inhibition] C5AR1 [activation] YWHAH [activation] 页 363 共 454


PCNA ACKR2 BUB1 NFKB2 OBSCN NCOA1 CD81 PRPF38A ATF4 NCAPD2 PRNP EIF4G2 MARCH1 GRIP1 U2AF1 MDM2 BID PHLDA3 IL6ST E2F2 TGFBR1 EXOC1 APOE CDKN1A CHRNA4 MAP3K4 PTPN13 ADRB2 CTNNB1 APP CD81 TNFSF12 YWHAG SMPD3 PACSIN3 KDR DNAJB4 SENP2 PTP4A3 MDC1 HOXB1 NCOA3 FANCA PCNA TP53BP2 PTK6 APP RGS12 DYRK1A HLX MYC MAPK3 TSSC1 RRAD PARD6A MAX GNAI1 STK4 AJUBA TIMM50 OBSL1 SRF CDC16 SIRT1 SMAD3 GADD45A FAM193B OBSL1 TP53 GRB2 GRB2 SH3KBP1 PIGR NPM2 OGT FIS1

RPA3 CCL13 MIS12 DDX21 ESR2 DDX17 ITGB1 POLA2 NEK6 RAD21 PTRH1 SKIL CD86 CSPG4 SRPK3 TOMM70A UBC NTRK1 LIF KMT2A NEK8 CCSER2 FARSA CCNB2 YWHAH PTPN11 RASSF10 ARRDC4 WHSC1 BTK TSPAN4 TRAF2 WWTR1 TNF SOS2 NCK1 RAD21 NUP153 MAD2L1 EP300 PBX1 KAT2B POLN CHEK1 ANXA1 CCT8 TPPP PLCB3 DNM1 EZH2 PLOD2 PFKFB1 CDK2 PRKCB TGFB1 AIP SSTR3 ABL1 TRAF6 ADRB2 CIT CREBBP ESR2 HSPA1L ATF2 ASCC2 CDC25A PHGDH BAK1 H1F0 CNTNAP1 BMPR1B CCL5 SRPK2 TRAK1 LRRK2

2016/4/8 19:15

[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 364 共 454


2016/4/8 19:15

GNAS ADRB2 [activation] BCL2L1 CASP8AP2 [activation] AIRE EIF4EBP3 [activation] PPP1R12A GRB2 [activation] ICT1 LONP1 [activation] URM1 NXF1 [activation] TNIK PAFAH1B1 [activation] LCK PAK2 [activation] DIXDC1 APP [activation] UBC EFNB2 [activation] PIK3R1 NFKBIA [activation] CDKN2A SP1 [activation] DNM1 PFN2 [activation] PARP1 FOXO1 [activation] TGFBR1 AMHR2 [inhibition] XIRP1 EVL [activation] OBSL1 MLLT4 [activation] HIF1A USP19 [inhibition] LHCGR CHST9 [activation] EPRS VCAM1 [activation] VCAM1 PPA1 [activation] LRRK2 CAMK2G [activation] RPA3 ATRIP [activation] PFN1 MAP1LC3B [activation] YWHAB ITGB4 [activation] ADCY5 PRKACA [activation] TNFSF11 PLK1 [activation] NCAM1 PRKCB [activation] AXIN1 GAK [inhibition] GADD45G SMARCB1 [activation] SH3KBP1 PDGFRB [activation] MAPK10 CREBBP [activation] GRB2 FRS3 [activation] EXOC5 RALA [activation] DHRS7 ETV5 [activation] TRAF6 HMGB3 [activation] BRCA1 STAT1 [activation] EGFR IPO5 [activation] WEE1 CRK [activation] RAD18 NBN [activation] MAPK1 MAFA [activation] FTSJ1 APP [activation] ABL1 ABI2 [activation] MRGPRX1 GNAI2 [activation] RABEP1 CASP3 [activation] MTPN FTSJ1 [activation] ADAM10 TSPAN17 [activation] JAZF1 RXRA [inhibition] GRB2 ARAP1 [activation] UBE2I RAD51 [activation] LRRK2 FAM27E3 [activation] JAK3 IL4R [activation] RELA PYCR2 [activation] SIPA1L3 YWHAZ [activation] TGFB1I1 GP1BB [activation] PTCH1 ITCH [activation] SHC1 SEC16A [activation] PPP2R1B NUP62 [activation] NXF1 OBSL1 [activation] CEBPA IL32 [activation] NUDC IFT122 [activation] BMPR2 SMAD7 [activation] APP ERVFRD-1 [activation] HTR2A LYN [activation] TLR1 TLR5 [activation] GNAO1 ADRA2A [activation] BCL9L YAP1 [inhibition] IRS4 CDKN1A [activation] RPS17 GABARAPL2 [activation] CTNND1 ERBB2IP [activation] REM1 YWHAZ [activation] FBXO5 CDC23 [activation] MMP12 TFPI [inhibition] MAP4K1 PLCG1 [activation] EVL HCK [activation] HIF3A EGLN2 [activation] 页 365 共 454


2016/4/8 19:15

RELA ATF3 [activation] PLEKHO2 YWHAE [activation] UBE2E2 MARCH3 [activation] TCP11 VAV2 [activation] TBK1 HSPA8 [inhibition] IGHE FCER1A [activation] CDKN2AIP WHSC1 [activation] HSP90AA1 FLT4 [activation] HSPBP1 TNFRSF14 [activation] ZAK EZH2 [activation] CASP10 RIPK1 [activation] TCF7L2 E2F3 [inhibition] NR1H3 NR3C1 [activation] MLH1 CTSV [activation] TRAF2 MORN3 [activation] CYLD UBE2S [inhibition] EGFR FLOT2 [activation] UBTD1 RANBP2 [activation] HOXB13 IRF4 [activation] PTPRJ KLK9 [activation] RNF125 UBE2E2 [activation] TIAM1 IGHA1 [activation] CCL14 DDX39A [activation] BCAS3 PALB2 [activation] ROCK1 GFAP [activation] TXNRD1 ESR1 [activation] MAP2K1 WNK1 [activation] GIT2 RUSC2 [activation] RINT1 RBL1 [inhibition] RPL7A ICAM1 [activation] DDAH2 CDKN1A [activation;inhibition] PTPN13 PRKACA [activation] APP PAK1 [activation] CCNH RPA3 [activation] SMURF1 CSNK2A2 [inhibition] PPP1CC GRB2 [activation] SH3GL2 ACTG1 [activation] HIF1A SMAD3 [activation] HRAS PRSS50 [activation] FANCG USHBP1 [activation] BMPR2 CAV1 [activation] LRP1 WNT3A [activation] KAT2B ACTN1 [activation] ARHGEF7 RAC1 [activation] LRRK2 ERG [activation] FLOT1 AURKB [activation] LIMK1 LATS1 [activation;inhibition] STK4 KPNB1 [activation] TGFB2 VTN [activation] EGFR RNF126 [activation] FYN CDCP1 [activation] PAXIP1 PCYT1B [activation] WHSC1L1 ESR1 [activation] YWHAB MINK1 [activation] PSEN2 CASP7 [activation] MLST8 PRR5L [activation] STK33 LRRK2 [activation] DUSP26 TP53 [activation] CCND1 PPP1CC [inhibition] CR2 FCER2 [activation] NCK1 BAZ2A [activation] RBBP5 KMT2A [activation] FYN HRAS [activation] NCKAP5L FBXW11 [inhibition] CRTC2 CDKN1A [activation] ABL1 DNASE1L2 [activation] JUNB NEU1 [activation] MYO1C PHLDA3 [activation] CCNE1 PIN1 [activation] TENC1 MYC [activation] TFDP2 YWHAE [inhibition] RBL2 CREG1 [inhibition] EZR CD44 [activation] BLNK CMTM3 [activation] LRP8 CLU [activation] HIF1A ARNT2 [activation] 页 366 共 454


2016/4/8 19:15

APBA3 EGFR [activation] MCM2 ESR1 [activation] JAK3 FES [activation] RPA1 CALD1 [activation] PIM1 MDM2 [activation] ATG5 LRRC59 [activation] ACTA1 TP53 [activation] MRE11A HTT [activation] FGD1 ELMO1 [activation] NKX2-1 SRC [activation] MYCN HDAC1 [activation] SLX4IP STK4 [activation] ACKR4 CCL13 [activation] JAK2 GRB10 [activation] STK16 MBP [activation] PAK1 BAD [inhibition] CSK PAG1 [activation] PCDHA4 SETDB1 [activation] HSP90AB1 ICK [activation] MLH1 FSCN1 [activation] TRAP1 GABARAPL2 [activation] ADAM17 MAD2L1 [activation] ASAH1 SETDB1 [activation] C1orf216 LINC00521 [activation] SMAD2 KPNB1 [activation] KCNA4 KCNA1 [activation] APC KRT19 [inhibition] SRSF6 PPARGC1A [activation] MDM2 FOXO1 [activation] RB1 FRK [activation;inhibition] EIF3F EGFR [activation] RARA FOXO1 [activation] CCR5 ORM1 [activation] SRC EGLN1 [activation] PRKCQ IRS1 [activation] HRAS RGL4 [activation] CDK2 POLD2 [activation] CLCF1 CRLF1 [activation] NPRL3 TP53 [activation] SKP2 DNAJB5 [inhibition] PRKDC ILK [activation] EFNB3 P2RX7 [activation] MAPK8 SPAG9 [inhibition] SASH3 APP [activation] ARFIP2 RAC1 [activation] PTBP1 NOTCH1 [activation] MTA2 TWIST1 [activation] IKBKE MYD88 [activation;inhibition] SATB1 EP300 [activation] PPARG STAT6 [activation] FBXL5 SKP1 [inhibition] EGFR IKBKG [activation] AATF EFNB3 [activation] EGFR PPARGC1A [activation] SGK3 PDK1 [activation;inhibition] RXFP1 RLN1 [activation] FTH1 HSPB1 [inhibition] PRPSAP1 PRKRA [inhibition] URB1 TAB1 [inhibition] FXYD6 TP53 [activation] SH2D1B APP [activation] EP300 FOS [activation] ACTB TSC1 [activation] NPB NPBWR1 [activation] CTCF SUMO1 [activation] ETS1 ARL6IP4 [activation] WEE1 CASP3 [activation] EP300 TNIP2 [activation] ANXA1 EGFR [activation] APP IRS1 [activation] FES KIT [activation] TRMT2A ANXA7 [activation] RASSF1 STK3 [inhibition] BTK AFG3L2 [activation] CALM1 SPP1 [activation] ADAMTS13 VWF [activation] 页 367 共 454


NCK2 GAB1 RELA MAPK10 TRAF2 CDC42 PLG IGHA1 L3MBTL1 SETD7 SUMO4 STRAP IL3RA CSF2RB CD81 DDX5 HSPB1 YWHAH MAN1A2 FOS MARK1 MAPT ATG5 TECPR1 MAGEC2 TP53 CRKL IRS4 RBL2 CCNA1 CDK1 NCAPG CSNK1E FAM199X NTRK1 RASA1 TSHR GNAI3 PPBP RAB10 ERBB2IP NR2E1 TRAF6 EIF2S1 SDF4 MME SMARCB1 ATM PRKCZ DAPK3 GNB5 GNG3 AKAP13 GNAQ ABI1 GRB2 GABARAPL2 PLCG1 DLGAP3 RGS7 GNB5 PCNA FBXO6 AR ACTB FAM110A GRB2 CBL CD5 MYOM1 C1QTNF9 YWHAG PPFIBP1 PIK3R1 CMIP HSPA5 TAB1 ACP1 EPHA2 JUN ERG MYL6 ATF2 LRIF1 TDGF1 HCLS1 FGR NUP88 RAE1 APP KIR2DL3 E2F3 SLC25A6 EGFR SPARCL1 PPARG ZNF496 PTGS2 PTGIS EIF4B PAK2 ADD2 PRKCD AURKA BARD1 CDKN1B RCHY1 TPM2 PIK3CG FTH1 TP53 CSF2RB LCK TFE3 YWHAG MAPK9 DUSP4 RPA3 PPP2CA GNB2L1 PAXIP1 PTPN6 TLR10 CCND1 MCM3 MAP4K1 SPRY1 MDM2 RELA CDK3 PPARA ADRBK2 CCR4 PSEN2 FBXL12 IRAK2 IRAK3 NOTCH2NL ENO1 ACACA ZFYVE19 CAPN7 IRAK1 SASH1 ST5 GRB2 MAPK8 ARHGDIA PAK2 GSTM3

2016/4/8 19:15

[activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] PRKCI [activation] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] GLP1R [activation] [activation;inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] 页 368 共 454


2016/4/8 19:15

CDC5L EIF4A2 [activation] RAE1 PRIM1 [activation] GAB2 LCK [activation] CCND1 CCNDBP1 [activation] TAL2 MAPK3 [activation] HSPB1 RBPJ [inhibition] EIF4A3 ITGA4 [activation] AXIN1 SMAD2 [activation] PLD2 FTSJ1 [activation] GADD45A SPTBN4 [activation] TRAP1 YWHAZ [activation] ICT1 RBFA [activation] LTA UMOD [activation] ACTB CDK5R2 [activation] MYB CSNK2A1 [activation] NCOA2 ESRRB [activation] CAPRIN1 VCAM1 [activation] PXN MAPK8 [activation] PNLIP YWHAE [activation] CD81 HIST3H3 [activation] IL2RG IL9R [inhibition] ATF1 CREM [activation] FGF1 FGFR4 [activation] TNFSF13 TNFSF13B [activation] TRPV4 PACSIN1 [activation] SKI AKT2 [inhibition] POLD3 POLD2 [activation] FLNA RHOA [activation] SELL PRKCQ [activation] JAK1 ABL1 [activation] TRAF3 DYRK1A [activation] FCAMR TP53 [activation] ARRB1 IGF1R [activation] CLCN3 HSPB1 [activation] ATF4 MAP2K7 [activation] DIABLO NGFRAP1 [activation] MYO1B MYC [activation] BCL2L1 GIMAP5 [activation] TIE1 PIK3R1 [activation] CTNNA3 JUP [activation] ANXA1 RPA1 [activation] TIMP3 ADAM17 [activation] EIF4A3 DDX39A [activation] WNK1 MAP3K3 [activation] CDKN1A DAPK3 [activation] NBN CHEK2 [activation] PAK1 CDK11B [activation] YWHAE CBL [activation] GRAP2 CD28 [activation] PIK3R1 RAC1 [activation] CBL IGF1R [activation] EIF4G2 EIF4A1 [activation] PTGDR GNAS [activation] CD46 CD151 [inhibition] AR RUNX1 [activation] AKR7A2 VCAM1 [activation] SKIL CDC16 [activation] ANXA1 FPR1 [activation] NTS NTSR2 [activation] SH3BP2 PTPN6 [activation;inhibition] PTK6 EFHC2 [activation] CD81 HIST1H1A [activation] SMAD1 PDGFRL [activation;inhibition] TNFRSF14 CCDC59 [activation] PPARG ALOX15B [inhibition] NEXN HSPB1 [inhibition] RHOA MPRIP [activation] RAP2B VCAM1 [activation] PRRC2A TP53 [activation] RAD21 IL7R [activation] LUC7L BARD1 [activation] PER2 MDM2 [activation] GDF7 BMP7 [activation] IRF2 EP300 [activation] CSNK1D ZDHHC17 [activation] SEMG2 TGM1 [activation] 页 369 共 454


2016/4/8 19:15

MARS MAP3K1 [activation] SLITRK4 LYN [activation] HIST2H2BE AURKB [activation] PSTPIP2 SHC1 [activation] CYBA NOX1 [activation] NOTCH1 RB1 [activation] FAM84B CTNNA1 [activation] ERBB2 PHF23 [activation] MCM7 EGFR [activation] NXF1 ZMYM4 [activation] MAP7D1 MYC [activation] PLA2G4A CASP3 [activation] HSF1 MAPK9 [activation] EP300 MAGEA11 [activation] RAB2A BLZF1 [activation] STAT1 KPNA1 [activation] ESR2 NOTCH2NL [activation] MAPT RPS6KA3 [activation] SOS2 CRK [activation] FBXW2 MYB [activation] GNB1 MCF2 [activation] CDKN1B CDK2 [activation;inhibition] HSP90AB1 MATK [activation] KIF23 USP8 [activation] SH2D1A TNK2 [activation] DDR1 FRS2 [activation] RUNX1 RUNX1T1 [activation] BHLHE40 STK19 [activation] MYB KAT2A [activation] NUCB1 GNAO1 [activation;inhibition] H2AFX ESR1 [activation] TCEB1 SOCS1 [inhibition] C9 LAMTOR5 [activation] IL1R1 TICAM2 [activation] GDF5 CHRDL2 [activation] CDH5 WARS [activation] ICT1 MRPS6 [inhibition] LGALS3 MICA [activation] BTK PRKCE [activation] AKT1 MAP3K8 [activation] SRPK2 POLB [activation] CDKN2C CDKN2A [activation;inhibition] CAMKK2 FLNC [activation] F12 HIF1A [activation] DDA1 PRKDC [activation] STX7 UBC [activation] ELAVL1 SETD3 [activation] CDK5RAP2 RBM48 [activation] STX1A SLC6A9 [activation] PPP2R5A JAK2 [activation] SCG2 TNF [activation] TRIM24 HDAC1 [activation] PFN1 CRMP1 [activation] SMURF1 FZR1 [inhibition] SERPINB10 SRPK1 [inhibition] PRKCG GRIA4 [activation] AMOTL2 MYO5B [activation] ARHGEF11 PLCG1 [activation] PLXNA2 IFT80 [activation] SYK CSF3R [activation] FOXP3 HDAC1 [activation] TNIP2 MKNK1 [activation] APP HBD [inhibition] MYC ASPM [activation;inhibition] TP53 USP11 [activation] ADCY9 HSPB1 [activation] PYCARD NLRC4 [inhibition] RPA3 ESYT1 [activation] KLK2 SERPINC1 [inhibition] PPP2CA PAXIP1 [activation] DERL2 SHH [inhibition] HNRNPA1 TP53 [activation] HSPB1 GAPVD1 [activation] CD44 MMP7 [activation] PYCARD ARMC2 [inhibition] PTGIR GNAQ [activation] 页 370 共 454


2016/4/8 19:15

SNAP23 ABI2 [activation] POLN HELQ [activation] ARHGEF11 PLXNB1 [activation] FGF3 TUBG1 [activation] MDM2 SETDB1 [activation] APP GPR12 [activation] SKIL FZR1 [activation] PPP6R3 LATS1 [inhibition] PTBP3 YKT6 [activation] CD36 COL1A2 [activation] APOH LDLR [activation] STMN2 CDK1 [activation] SRPK3 SON [activation] UBASH3B FAM168A [activation] TRAF6 HSPA9 [activation] PLK2 MPP3 [activation] AR PLCG2 [activation] HEMGN SMAD4 [activation] NFATC1 RPS6KB1 [activation] SIRT1 RARA [activation] PEAK1 GRB2 [activation] TGFBR2 DAB2 [activation] ITGA8 ITGB1 [activation] HIST2H3A TAF1B [activation] ATP13A2 CXCR4 [activation] STK4 AURKB [activation] OBSL1 HIST2H2BE [activation;inhibition] ITGA5 FLT4 [activation] HSPB1 STK4 [activation] PRICKLE3 CRK [activation] IRAK2 TLR4 [activation] GRN FANCL [activation] OLFML3 HSPB3 [activation] IGF2BP2 EIF2AK2 [activation] IRS1 SIRT1 [activation] ARSF EP300 [activation] FLOT1 SORBS1 [activation] PPIA JAK2 [inhibition] EPHA2 KPNA3 [activation] SRC CTTN [activation] DOCK9 NEDD9 [activation] SRF MINPP1 [activation] LRRK2 COPE [activation] PDXP STK11 [activation] SFN HDAC4 [activation] GAB1 PARD3 [activation] TP53 COPS4 [activation] BAD CDKN1A [activation;inhibition] HSPG2 PDGFA [activation] SLC9A2 RASA1 [activation] CHRNA5 SRPK2 [activation] PXN ITGB3 [activation] CD40 IL4R [activation] RIN3 CRK [activation] HNRNPA1 VCAM1 [activation] CHUK ACTG1 [activation] HSPA7 GABARAP [activation] SMAD1 GDF6 [activation] CITED2 CREBBP [activation] TNFRSF21 NSD1 [activation] BACE1 PLSCR1 [activation] SRC SH3BP1 [activation] PLXNB1 MST1R [activation] TOMM34 VCAM1 [activation] RBL2 CCND1 [inhibition] PFN1 RAD51 [activation] MPP3 TRAF2 [activation] EPB41L5 ESR1 [activation] NGFR PTPN13 [activation] ADRA1A BMP1 [activation] PAK6 MAPK14 [activation] BLNK MAP2K4 [activation] LAMB1 EIF3I [activation] KIAA1522 SFRP1 [activation;inhibition] MATK NTRK1 [activation] TNK2 NTRK2 [activation] 页 371 共 454


2016/4/8 19:15

CDX1 LGR4 [activation] RAD21 SMC2 [activation] ERBB2 STK24 [activation] DPYSL2 MICALL1 [activation] CDH5 SMG1 [activation] YWHAZ TSC1 [activation;inhibition] BST2 MYD88 [activation] EGFR YTHDF1 [activation] CNKSR1 RHOD [activation] ZAP70 FCGR3A [activation] PRKCB CSF2RB [activation] TSSK3 SMAD4 [activation] SH2D1A LCK [activation] EFS ABI2 [activation] NACAD MAP4K2 [activation] PAWR PRKCZ [activation] C16orf80 YWHAG [activation] HCK SRC [activation] EFNB1 CAP1 [activation] CMTM5 ARMC9 [activation] CSNK2B VRK3 [activation] SRC JUP [activation] HSP90AB1 TP53 [activation] ARF3 ITGA4 [activation] CREBBP CDC16 [activation] CDK20 CCNH [activation] KIT SH2B2 [activation] SOCS3 KIT [inhibition] LEO1 KMT2A [activation] ERCC4 ERCC6 [activation] IKBKB IKBKG [activation] EPHA4 FGFR2 [activation] PIK3CB GRB2 [activation] BRPF3 ABL1 [activation] RAD51D IKZF1 [activation] PSEN1 CASP6 [activation] ITGA4 NTPCR [activation] EGFR ALDH3A2 [activation] BCL2L1 CLU [activation] SAFB2 SRPK1 [activation] RPS6KA3 CREBBP [activation] PPM1A CACNA1A [activation] LYZ A2M [inhibition] HSP90AB1 FLT4 [activation] DLGAP1 PLCG1 [activation] EPHA3 CDKN2A [activation] MAGEB4 RUNDC3A [activation] RHOD HRAS [activation] ADRB2 GNA15 [activation] TNFAIP3 TNF [activation] SLX4 IGHA1 [activation] SMYD2 IGF2BP1 [activation] CREB1 DYRK1A [activation] LZTFL1 FZD5 [activation] ARHGEF1 PIK3CA [activation] SPP1 AMOTL2 [activation] TRAF2 WDR65 [activation] MRPL12 RELA [activation] PLCG1 PECAM1 [activation] MCF2L2 MYC [activation] FAM124A PRKG1 [inhibition] HIF1A USP8 [activation] SNCA APP [activation] TAF1B TAF1D [activation] HSPB1 SNW1 [activation] RAC3 WAS [activation] FTSJ1 NUTF2 [activation] RPS14 ICAM1 [activation] GLOD4 BCL2L1 [activation] PBX1 SMARCA4 [activation] ARHGDIA RAC1 [activation] RGS6 GNB3 [activation;inhibition] SEMA3B PAK6 [activation] HSPB1 PPM1A [activation] LAT MAP4K1 [activation] OBSL1 HIST2H2AA3 [activation;inhibition] 页 372 共 454


2016/4/8 19:15

GJA1 CSK [inhibition] CASP7 PTGES3 [activation] HPRT1 TRAF6 [activation] PLEKHA6 PLEKHA5 [activation] SRF FLI1 [activation] RNF138 LEF1 [inhibition] CPNE3 USP42 [activation] LYVE1 VEGFA [activation] PDGFRB SLC9A3R1 [activation] RBL2 HDAC1 [inhibition] CTCF TOP2A [activation] IQGAP1 PRKACA [activation] MYC DUSP15 [activation] SP1 TBP [activation] PDPK1 PAK1 [activation] ATM ATRIP [activation] AKT1 CAMKK1 [activation] CALM1 HMMR [activation] PRKACA RAP1GAP [activation] MITF YWHAZ [activation] GRB2 SIGLEC7 [activation] GNL3 MYC [activation] BCL6 HDAC1 [activation] HLA-B SNRPB2 [activation] TFDP2 RBL1 [inhibition] IGHM GSK3B [activation] MMP3 HAPLN1 [activation] APP EIF2B5 [activation] APPL1 RAB5A [activation] KCTD3 SRC [activation] HSPA5 F8 [activation] IGF1R EGFR [activation] TSC1 PLK1 [activation;inhibition] CKAP5 FYN [activation;inhibition] TGFBR1 EP300 [activation] EP300 SMAD5 [activation] CASP4 VDAC3 [inhibition] SHC1 TUBA8 [activation] USF1 FOSL1 [activation] TFDP1 LIN9 [inhibition] RAF1 SRC [activation] HTT RASA1 [activation] YAP1 SUMO1 [activation] IRS4 USP9X [activation] GNAI2 LHB [activation] RACGAP1 FZR1 [activation] SH2B1 GRB2 [activation] ACTA2 EGFR [activation] BCL2L1 ACTB [activation] BUB1 CDC5L [activation] SMAD1 APC [inhibition] DHPS ARF6 [activation] GNB2L1 NFATC1 [activation] DPYSL2 DPYSL3 [activation] EGFR TELO2 [activation] CDK1 CSNK2B [activation] GLRX2 BAG3 [activation] RPA3 CSNK1A1L [activation] SERPING1 F2 [inhibition] HSPA8 IKBKB [activation] HMMR CDH13 [activation] COL1A1 BARD1 [activation] MAP4K1 HSP90AA1 [activation] APP GOSR1 [activation] SCUBE1 SCUBE2 [activation] PPP2R1A NUP62 [activation] ADORA2B NTN1 [activation] PREX2 MYC [activation] CDK1 HMGB1 [activation] ARHGEF2 FYB [activation] NXF1 MRPL15 [activation] TLX1 ETS1 [activation] FAM90A1 SRPK2 [activation] FOXP3 PRR20E [activation] PTPRB GHR [activation] ANAPC2 MAGEB2 [activation] 页 373 共 454


2016/4/8 19:15

GATA1 HSPA4 [activation] GRB2 GHR [activation] SEMA6A ITSN2 [activation] PPP2CA CDK6 [inhibition] UBE2E2 RNF185 [activation] HSPA5 SMURF1 [inhibition] SKIL TSKU [activation] SERPINA1 MMP26 [inhibition] ARF5 PIP5K1A [activation] SMURF1 DDX21 [inhibition] POMGNT2 APP [activation] STAT5A STAP2 [activation] C1orf52 ETS1 [activation] TRPV4 CALM1 [activation] CALM1 RGS2 [activation] NFASC ABL1 [activation] RAC1 CDC23 [activation] VCAM1 RCC1 [activation] NRAP ACTB [activation] ABI1 RASA1 [activation] CTNNB1 SIRT1 [activation] MLLT4 RAP1GAP [activation] DYSF OS9 [activation] CEBPB EGR1 [activation] IRS1 TUB [activation] CALM1 CHUK [activation] GATA1 STAT3 [activation] EDA2R FADD [activation] ELAVL1 NOS3 [activation] TH YWHAG [activation] CDC5L EHD1 [activation] CFL1 FN1 [activation;inhibition] TBXA2R GNAS [inhibition] PPM1B VAV2 [activation] NFYC SMAD3 [activation] CYP51A1 ETS1 [activation] ITGB3 YES1 [activation] CDC20 CDC23 [inhibition] MOAP1 BAX [activation] BRCA1 CHEK1 [activation] GRM5 CALM1 [activation] EPB41 EIF1 [activation] HIST1H1C F10 [activation] MAPT GSK3A [activation] ERCC6 KAT2B [activation] FCHSD2 DAPP1 [activation] JUP PSEN1 [activation] EGFR SAAL1 [activation] ATF2 THRB [activation] SRSF4 PPARGC1A [activation] CDC23 INCA1 [activation] CASP8 LYPD3 [inhibition] HSP90AB1 CAMK2B [activation] DAB2IP FBXW7 [activation] DDX58 TBK1 [activation] STAT3 STAT4 [activation] DAB1 ITGB7 [activation] KCNA4 FYN [activation] ESR1 SLC25A6 [activation] AMOT CTNNB1 [activation] MEN1 RELA [activation] SNAPC3 GRB2 [activation] PKM RAP1B [activation] PLK1 TRIOBP [activation] FAS FAIM2 [inhibition] OTUD6A CBLC [inhibition] SIRT1 PHLDB3 [activation] EIF4A1 H2AFX [activation] ULK1 PRKAA1 [inhibition] NCF1 PRKCZ [activation] YWHAE SRGAP2 [activation] CAV1 STRN [activation] OPRL1 GNA14 [activation] UBTF CCND1 [activation] BIRC2 UBE2V1 [activation;inhibition] GEMIN4 ILK [activation] 页 374 共 454


2016/4/8 19:15

UBE2E2 RNF4 [activation] NXF1 CD2BP2 [activation] CLASRP CDK6 [inhibition] OXSR1 TGFBR2 [activation] FOS VDR [activation] PPP2R5A PPP2R5D [activation] SPP1 EIF3K [activation] LRP1 EGFR [activation] GNAI1 PTH1R [activation] MIDN GADD45A [activation] ELANE F2RL1 [activation] RAB5A RABGEF1 [activation] HSPA6 NOS2 [activation] MAP3K5 CREBBP [activation] FARSB FARSA [activation] APP NUMB [activation] PTPN12 SFRP4 [activation] GRB2 FAU [activation] NCL LRRK2 [activation] MAP2K3 UBC [activation] HSP90AB1 YWHAZ [activation] RELN DAB1 [inhibition] SMAD2 ANAPC2 [activation] RASGRP3 APP [activation] STAT6 CEBPB [activation] RPRD1A RIOK2 [activation] HIST1H4A CCDC8 [activation;inhibition] SUCLG2 MDM2 [activation] RPL26 FTSJ1 [activation] MCM7 CTNND1 [activation] ESRRA NCOA1 [activation] BAAT PDGFRL [activation;inhibition] KLK3 A2M [inhibition] TNFRSF13B TNFSF13 [activation] F12 UBE2D3 [activation] ARHGDIB APP [activation] RPA2 PRKDC [activation] PCBP1 SRPK3 [activation] BCL2L1 ANTXR1 [activation] POLR2A NXF1 [activation] BAZ1B VDR [activation] ECT2 CDH1 [activation] TRIO RAC1 [activation] ZYX SREBF2 [activation] KIAA0226 EGFR [activation] HSPA1L PIK3R2 [activation] LEPR LEPROT [activation] GPR50 MTNR1A [activation] BMP7 ENG [activation] VCAM1 TRAPPC3 [activation] HDAC3 TP53 [activation] CDKN2C ATR [activation] MDM2 CKAP4 [activation] KDR GRB10 [activation] GRB2 DLGAP3 [activation] MECOM CREBBP [activation] ERBB2 PTK2B [activation] KLHL38 RGS20 [activation;inhibition] IKBKB TRAF1 [activation] STK39 MAPK14 [activation] FKBP5 HSF1 [activation] ARL15 B4GALT3 [activation] PRKAA1 HSP90AB1 [activation] YWHAZ PRMT5 [activation] ABI1 CACNA1A [activation] SMAD3 RIT1 [activation] ROS1 PTPN11 [activation] LRRK2 DUX3 [activation] PRKCZ CASP6 [activation] GNAO1 GABBR1 [activation;inhibition] CTBP2 EGFR [activation] ABLIM3 GRB2 [activation] DIAPH1 CDC7 [activation] KATNA1 KATNB1 [activation] CSPG4 CDC42 [activation] SORBS1 PTK2 [activation] 页 375 共 454


2016/4/8 19:15

MAPK6 GLRX3 [activation;inhibition] RNF32 NOS3 [activation] IGF1 IGFBP2 [activation] CYFIP2 SMAD4 [activation;inhibition] CRK GLTSCR1 [activation] ATM CHEK2 [activation] JAK3 MAGED2 [activation] STX4 RAB5A [activation] OGT SP1 [activation] ANXA7 S100A10 [activation] IL17A TRAF6 [activation] OSGIN1 PTEN [activation] WNT3A WNT1 [activation;inhibition] WWTR1 WNK1 [activation] PTGES3 HIF1A [activation] TRIP6 VCL [activation] HSP90AB1 MAP3K6 [activation] AR PIK3R3 [activation] MAPK1 FRS3 [activation] CREBBP CDKN1A [activation] ETS1 SERBP1 [activation] VIP MEP1A [activation] DYSF NPHP3 [activation] GIT1 GRB2 [activation] SPP1 FTH1 [activation] PRDX3 IKBKB [activation] SRPK1 MAP1LC3A [activation] RHOA SMAD2 [activation] CC2D1B SPP1 [activation] HDAC3 SYK [activation] PLK1 CSN2 [activation] RIPK1 CARD6 [activation] CDK5RAP2 PTN [activation] SST SSTR3 [activation] RUNX1 NCOR2 [activation] CDC25C SFN [activation] AKT1 CCNA2 [activation] CSF3R HCK [activation] TDRD3 HIST3H3 [activation] NCAPD2 NCAPH [activation] INADL YAP1 [activation] HSP90B1 EGFR [activation] IGF1 IGFBP6 [activation] BMX C12orf45 [activation] MKNK1 PRKDC [activation] RAD9A CLSPN [activation] THBS1 COL4A1 [activation] MMP2 EPHB2 [activation] APP CDC7 [activation] DDX21 IL7R [activation] YWHAB RACGAP1 [activation] CCND1 PRKACA [activation] AKT2 STEAP4 [activation] PAFAH1B1 PAFAH1B2 [activation] RAD21 CALML5 [activation] STK3 RASSF2 [activation] HSPB1 PPP2R3C [activation] PDAP1 PDGFRB [activation] RAD54B C9orf156 [activation] FZR1 CDC16 [activation] PRKCI PARD6B [activation] GAD2 F10 [activation] NCOA1 HIF1A [activation] RANBP9 MET [activation;inhibition] MYO1C GRB2 [activation] LATS1 KIRREL [inhibition] SYK JAK1 [activation] FOXO1 MST1 [activation] CAMK2G HSP90AB1 [activation] PLCB3 TRPM7 [activation] ACTB CBL [activation] CHTOP SRPK3 [activation] PPM1A ASB2 [activation] IRAK3 IRAK1 [activation;inhibition] CACNA1S RIMS2 [activation] KMT2B BCL6 [activation] 页 376 共 454


2016/4/8 19:15

KCNIP3 IGLC2 [activation] STK4 ERC1 [activation] C1QTNF2 HPCAL1 [activation] PRKCZ CASP3 [activation] NAV3 APC [inhibition] ADRA1B PRKCA [activation] PRR14 PPP2CA [inhibition] WHSC1 DDX18 [activation] MOB1A SGK1 [activation] ACTG1 PTPRO [activation] LYN DOCK8 [activation] PTPN11 CAV1 [activation] IL27RA EBI3 [activation] DYRK1A PHYHIP [activation] RAD54L2 AR [activation] MATK MET [activation] DLG4 NLGN4X [activation] MAPK13 ENO1 [activation] NUTM1 PRKAA2 [inhibition] FLNA MYB [activation] CUEDC2 MAD2L1 [inhibition] HSPA1L CEP250 [inhibition] MAP2K5 BAD [activation] RAC1 VAV1 [activation] MDM2 RARS [activation] EFNA3 NOTCH2NL [activation] CCDC8 FYN [activation] WNK1 HIVEP2 [activation] RPF2 NXF1 [activation] PIAS2 ESR2 [activation] RALY PIK3CD [activation] TNK2 KCNA5 [activation] PKP4 PSEN1 [activation] FAM208B ERH [activation;inhibition] ANAPC5 FBXO5 [inhibition] SIPA1L2 ESR2 [activation] PF4 CCL5 [activation] STK4 KIF2A [activation] SERPINE1 ORM1 [inhibition] PTPN1 CDH2 [activation] FYB FASLG [activation] CCDC8 IQGAP1 [inhibition] MDM4 RB1 [activation;inhibition] PER1 TIMELESS [activation] TGFBR2 ZFYVE9 [activation] GRB2 ELK3 [activation] PPP2R5D CHEK2 [activation] ARHGAP15 TGFBR1 [activation] DCLK1 APP [activation] SPARCL1 TNF [activation] KIAA1377 RAN [activation] HDAC1 NFKB1 [activation] FBXO5 ANAPC2 [activation] CTCF HIST2H2AC [activation] GPBP1L1 LRRK2 [activation] EPHB1 GRB2 [activation] CHEK1 SLX4 [activation;inhibition] KIAA1598 MEGF10 [activation] APPL1 CTNNB1 [activation] TOP2B NOTCH1 [activation] SMAD3 CHD8 [inhibition] SELPLG VCAN [activation] ROR2 FZD5 [activation] RANBP2 CDCA8 [activation] GLRX ATP7A [activation] RAC1 USP6 [activation] KLRC4 MICA [activation] LUC7L2 GRB2 [activation] HSPA2 HSPBP1 [inhibition] FYN WBP11 [activation] PSMD10 RHOA [activation] SRPK2 STON1 [activation] TTC7A MCM7 [activation] KNG1 ITGB2 [activation] SKAP1 FYN [activation] TWF2 CAPZB [activation] 页 377 共 454


2016/4/8 19:15

CMYA5 IL6ST [inhibition] HERC5 CCND1 [inhibition] PPP2R1A GABARAPL2 [activation] ANGPTL4 PTK2 [activation] EVL FYN [activation] SRPK1 ALKBH3 [activation] MAPK1 PPARG [activation] RHOB ARHGEF3 [activation] BRAF TIMM50 [activation] PTPN6 GRB2 [activation;inhibition] RHOD IHH [activation] PAK3 MYO6 [activation] PDGFRB SLA [activation] MAGED2 LRRK2 [activation] YWHAE HSF1 [activation] PRKACA GAD1 [activation] GNAQ HTR6 [activation] DYSF FAM65B [activation] DAG1 FYN [activation] ADA GRB2 [activation] TNS1 PTK2 [activation] CACNA1A HHATL [inhibition] PLCG1 FGFR4 [activation] NUP214 VCAM1 [activation] HMGCS2 YWHAZ [activation] ARPC5 ARPC3 [activation] ASB6 FGG [activation] MYB SP100 [activation] BMPR1B KLHL1 [activation;inhibition] STK4 STAT1 [activation] KCNQ1 KCNE2 [activation] C6orf136 PLK1 [activation;inhibition] SUMO1 THOP1 [activation] FURIN PDGFA [activation] SOCS1 TEC [inhibition] TP53BP1 ACR [activation] CASC1 PPP1CA [activation;inhibition] LCP2 SHC1 [activation] ZBTB17 HSPB1 [activation] FANCA MKNK1 [activation] C1R C1QB [activation] PRKCB GABRG2 [activation] PLK1 CTBP1 [activation] AURKB MTMR1 [activation] CHD1L RPA3 [activation] EGFR PNPLA2 [activation] MYBL2 LIN52 [inhibition] SRSF5 ESR2 [activation] EGFR SNRPA1 [activation] UNC5B NEO1 [activation] PRDM6 EHMT1 [activation] TLR9 TRAF3 [activation] LMTK2 CDK5R1 [activation] VAV2 BZW1 [activation] IKBKB PPM1B [activation] USP9X PSD4 [activation] PRKG1 CRIP2 [inhibition] COL3A1 FGF7 [activation] PIN1 MTFR1 [activation] ITGA4 PAFAH1B3 [activation] DDX24 TMEM9B [activation] HSPB1 INS [activation] PRKCD ACTA1 [activation] YWHAE CRTC1 [activation] FGF3 FGFR3 [activation] RAPGEF1 NEDD9 [activation] APPL1 RHEBL1 [activation] HLA-B PEBP1 [inhibition] CASP1 NOD1 [activation] STAT1 STAT2 [activation] DEFA1 SERPINF2 [activation] FANCG GABPB1 [activation] EGFR MAST1 [activation] EZH2 MAPKAPK3 [activation] GPR3 ARRB2 [activation] SMAD5 SMURF1 [inhibition] 页 378 共 454


AURKB GSTK1 YWHAG LYN MYOD1 EIF3F DAG1 MYC NCOA3 CDKL3 TRIP6 TNK2 FAM19A4 PRC1 IL13 SH3D21 CEBPB PRKACA PAK1 YWHAB AARS2 TNF PXK NFATC1 MYC BAZ1B PRKACG HLA-A YWHAZ ARRB2 IGHG1 PLK1 SHC1 LGALS13 MYB LCK SMAD2 PDIA4 APP VCAM1 CALM1 ATF2 IRAK3 PDGFA EGFR ADAM17 CTNNBL1 MVP MYO1C HNRNPL MST1R PPARG MAPK1 PITX2 MAP2K4 F12 IPCEF1 VCAM1 GPR1 CD55 MLST8 MVP CCDC53 CDK13 AFAP1 CRKL RAB5A NR3C1 EIF2B1 SCRIB LATS1 STX6 PIK3R1 UBC APC WNT2

2016/4/8 19:15

KIF5B [activation] EHD4 [activation] KIAA0930 [activation] LIME1 [activation] SMAD4 [activation] EIF4G1 [activation] CAV1 [activation] PML [activation] MAPK1 [activation] CDK6 [inhibition] DHX37 [activation] AR [activation] APP [activation] CCNB1 [inhibition] IL13RA2 [activation] EGFR [activation] SMAD3 [activation] CALD1 [activation] ARHGEF6 [activation] CDC25B [activation] ICT1 [activation] AGO2 [activation] PIK3R1 [activation] EGR1 [activation] MAP2K1 [activation] IGHM [activation] TNP2 [activation] STAT3 [activation] PRDX2 [activation] MCM3 [activation] KLK3 [activation] FADD [activation] DOK1 [activation] ACTG1 [activation] ADAM22 [activation] CD3E [activation] EPB41L5 [inhibition] VWF [activation] RASGRP2 [activation] CORO1C [activation] GAP43 [activation] FOS [activation] HSP90AB1 [inhibition] COL5A1 [activation] ERCC4 [activation] EED [activation] HSPA4 [inhibition] NOTCH2NL [activation] MCM7 [activation] SMYD2 [activation] EPOR [activation] PML [activation] NR3C1 [activation] MYC [activation] CFLAR [activation] MMP14 [activation] CYTH4 [activation] NUP210 [activation] TPST1 [activation] CD14 [inhibition] AKT1S1 [activation;inhibition] RIMBP3 [activation] HSPB1 [activation] ARRB2 [activation] PRKCB [activation] MOV10 [activation] RAB4A [activation] FYN [activation] EIF2B3 [activation] MAP3K3 [activation] PTEN [activation;inhibition] STX4 [activation] GLTSCR1 [activation] ERO1L [activation] NUPL2 [activation] UQCR11 [activation;inhibition] 页 379 共 454


NEK9 ACTB CDK6 LRCH3 PIM1 APP RAF1 AIRE SHANK1 RASA1 WDHD1 CDK5R1 FGFR2 ATF4 HOXB4 ACTB GLTSCR1 TRAF2 ABL1 TP53BP1 FYB MTPN FANCL PGK1 NUP88 RAD51C IQGAP1 ILK TRAF6 NDUFS3 ACTB KIT ESR1 IRS2 YWHAH C7orf25 FBXO28 PPP1R11 RCHY1 PTPRJ SRSF6 CAMK1 NDUFS1 CENPC ITK ARHGDIB EXOC7 PIK3R1 STK4 BRD4 YWHAH YWHAZ PPP2CA NTRK2 PRPSAP1 KRT23 ACTA1 BHLHE40 KAT2B TPT1 HIST3H3 EGFR DNAJA3 BAG2 SRC TRAF2 CDC16 PLEK BDKRB1 NDEL1 UBE2I MDM4 CUL1 ANK1 CACNA1C TSPAN7

2016/4/8 19:15

MDM2 [activation] DSTN [activation] CASC3 [activation] LRCH1 [activation] BMX [activation] C11orf45 [activation] HSP90AA1 [activation] CRK [activation] STAT1 [activation] AURKB [activation] SRC [activation] ACTN1 [activation] LYN [activation] FOS [activation] MEIS1 [activation] APP [activation] MYC [activation] DLGAP5 [activation] SPRR2A [activation] ATM [activation] FER [activation;inhibition] TRAF6 [activation] DOCK8 [activation] UBA5 [activation] MCM7 [activation] APP [activation] RPA1 [activation] PCID2 [activation] LAT [activation] ILK [activation] PPP1CA [activation] CSF2RB [activation] RELA [activation] BCL2 [inhibition] REM1 [activation] MTOR [activation] LYN [activation] LATS1 [inhibition] CHEK2 [activation;inhibition] PKP4 [activation] ESR1 [activation] CCND1 [activation] CASP3 [activation] MAPK14 [activation] WAS [activation] CASP7 [activation] CDC5L [activation] TGOLN2 [activation] SAV1 [activation] PIK3R1 [activation] IRS2 [activation] EIF4G1 [activation] PPP2R2C [inhibition] FRS2 [activation] ILK [activation] APC [inhibition] KIF23 [activation] SETDB1 [activation] HIST1H2BB [activation] SMAD2 [activation] MTA2 [activation] AURKA [activation] IFNGR2 [inhibition] MOS [inhibition] TRAF6 [activation] USF1 [activation] SH3KBP1 [activation] TGFBR1 [activation] KNG1 [activation] KATNA1 [activation] NR3C1 [activation] TRIM46 [activation;inhibition] RAC2 [activation] TGFBR1 [activation] HDAC4 [activation] CACNA1A [inhibition] 页 380 共 454


DAB1 NEDD1 BRCA1 YWHAE TDRD7 RPTOR ZAK MAP3K5 BCR PALB2 CSNK1A1 TNXB SMAD4 MYBL2 CDC5L SFN BARD1 SPIB EGFR HIST3H3 CRKL BEX1 STK3 CHRM2 MRPS22 CHEK2 DCN GP6 SMAD2 LDOC1 MDM2 SRPK1 ATF1 CTNNB1 CASP4 STX7 RNF8 SKP2 CCT6A PFKFB1 SKP1 NCOA2 MAPK1 NXT1 ST3GAL3 BANP WISP1 YWHAE TLR2 SMAD4 ZIC2 STX1A ITGA4 JUP KMT2A CDC7 ACVRL1 IL2 ZAK POLR2A ATG16L1 ARVCF PML KDR PAG1 CRK KMT2E LHCGR DDX21 PSEN1 RAN RAB5C TRAF2 ELAVL1 CDKN1A ZNFX1

2016/4/8 19:15

HMBOX1 [activation] HSPA1L [activation] CREBBP [activation] PPM1B [activation] NRAS [activation] MAPK1 [activation;inhibition] SFN [activation] SOCS3 [inhibition] VAV1 [activation] FAM84B [activation] ITGA4 [activation] E2F3 [activation;inhibition] MAX [inhibition] LZTR1 [inhibition] TIAL1 [activation] SGK223 [activation] BCCIP [activation] CEBPB [activation] SOCS1 [inhibition] NCOA2 [activation] GABARAPL1 [activation] SMAD4 [activation] STRN3 [activation] GPRASP2 [activation] TP53 [activation] MDC1 [activation] MMP3 [activation] LYN [activation] FOXO3 [inhibition] LATS1 [inhibition] NRAS [activation] GABARAP [activation] HNF1B [activation] PTPN1 [activation] UFL1 [activation] CREB3 [activation] CHEK2 [activation] FKBPL [activation] ILK [activation] PASK [activation] MAP4K1 [inhibition] CTNNB1 [activation] PPP1CA [activation;inhibition] NXF2 [activation] ACTG1 [activation] MDM2 [activation] DCN [inhibition] VAMP8 [activation] TLR6 [activation] PPP3R2 [activation] PRKDC [activation] KCNB1 [activation] RPS17 [activation] GJB1 [activation] INS [activation] ORC6 [activation] BAMBI [inhibition] NGFR [activation;inhibition] DDAH2 [activation] EGLN2 [activation] CASP6 [activation] CDH2 [activation] STAT3 [activation] GNA11 [activation] RASA1 [activation] DSC1 [activation] OGT [activation] SLC9A3R1 [activation] MDM2 [activation] PSEN2 [activation] MBP [activation] APP [activation] DIABLO [activation] FGF21 [activation] NR1H2 [activation] MEGF10 [activation] 页 381 共 454


2016/4/8 19:15

BID ITCH [activation] SERPINB4 MAPK8 [inhibition] FYN SOS2 [activation] PTK2 HES1 [activation] NKX2-1 NCOA2 [activation] MAP3K1 EPHA1 [activation] ANKRD13C PTGDR [activation] PRNP ERI3 [activation] PTEN PDGFRA [activation] GDI1 FTSJ1 [activation] KPNB1 RAPGEF3 [activation] TP53 CCT8 [activation] CD3E CD3EAP [activation] VCAM1 GLRX3 [activation] KAT2B HIST2H2AC [activation] C8orf59 LRRK2 [activation] ENO2 TINF2 [activation] ACTB MAP2 [activation] RARS VCAM1 [activation] ANAPC7 ANAPC16 [activation] MAPKAPK5 SRPK1 [activation] LIN37 LIN9 [inhibition] TAF1B MYC [activation] RARA TRIM24 [activation] SMAD3 HSPA4 [inhibition] ANXA5 BAG3 [activation] SMARCC2 GATA1 [activation] CFL1 ATF2 [activation] SGK1 SLC1A3 [activation;inhibition] KDR COL18A1 [activation] CDKN2A PRKCA [activation;inhibition] TTC27 EGFR [activation] SKP2 MYBL2 [inhibition] FGFR4 OSGIN1 [activation] RANBP9 NR3C1 [activation] ACTB ITGA4 [activation] GAPDH GRB2 [activation] TGM2 ITGB1 [activation] ATRIP MOS [activation] ARHGDIA FAS [activation] FBP2 MAP2K4 [activation] DOK4 RASA1 [activation] PCDHA7 ABL1 [activation] PPARG ROBO4 [activation] CBL PTPN6 [activation;inhibition] TP53 HDAC9 [activation] SFN LRRK2 [activation] SOCS1 CYTIP [inhibition] EP300 HOXD10 [activation] YWHAE ARHGEF2 [activation] TNFRSF12A TRAF3 [activation] FYN CNN1 [activation] RBBP4 ZFPM1 [activation] FBXO9 CALM1 [activation] VAV2 RAC1 [activation] FTSJ1 ANXA2 [activation] SERPINA4 GADD45G [inhibition] FZR1 MOAP1 [activation] MTOR RAB1A [activation] PLG SERPING1 [inhibition] EGFR NUMB [activation] HSBP1 HSF1 [activation] SYNGAP1 ULK2 [inhibition] AKT1 BUB1 [activation] BRCA1 ATF1 [activation] DMC1 RAD51 [activation] NFKBIA HOXA9 [activation] MTA3 CDH1 [activation] PRKACA RASGRP3 [activation] PRPF4B SRPK3 [activation] FBXL21 CUL1 [inhibition] DPYSL4 DPYSL2 [activation] ATR POLN [activation] RXRA ACVR1B [inhibition] CTNNA1 ARRB2 [activation] CCNA1 SKP2 [activation] 页 382 共 454


2016/4/8 19:15

EVL ABL1 [activation] LPAR1 ARHGEF11 [activation] DOK4 FYN [activation] CDX2 MAPK14 [activation] SHC1 RB1 [activation] HIPK2 EP300 [activation] AR LCK [activation] TGOLN2 GRB2 [activation] NUP214 SUMO2 [activation] RXRA BRD8 [inhibition] GNAI2 TSHR [activation] TP53 FLNA [activation] DVL3 PIK3CB [activation] NTRK3 JUN [activation] PIK3R2 ABI1 [activation] SDC2 PYHIN1 [activation] SRPK1 SLC4A1AP [activation] EGFR DARS [activation] KCNAB2 RPA3 [activation] CASP3 MDC1 [activation] GFPT1 PRKAA2 [activation] CREBBP RPA2 [activation] ERH PVRL4 [activation] SRSF10 SRSF1 [activation] SUMO2 AURKB [activation] PORCN WNT7B [activation] MDM2 RPS17 [activation] PAX3 FYN [activation] IFIT1 IFIT2 [inhibition] PAXIP1 SRSF1 [activation] TIMM50 RAF1 [activation] ACTN1 ESR1 [activation] VAV2 GRB2 [activation] RPS6KA3 HMGN1 [activation] KPNB1 CDK11A [activation] SMAD4 SUMO1 [activation] TCF4 INS [activation] PAXIP1 EP300 [activation] ART3 PRKCD [activation] ERCC4 TADA2A [activation] SUMO3 EHMT1 [activation] HSPA8 HIF1A [inhibition] NDEL1 CCSER1 [activation] SDC3 EPHB4 [activation] STAT1 PDGFRA [activation] BARD1 KPNA3 [activation] TGFBR1 SKAP2 [inhibition] FCHO1 ACVR1 [activation;inhibition] SUMO4 IDH1 [activation] PDIA6 TNFRSF14 [activation] CYC1 CYCS [activation] LCA5 SRPK2 [activation] TTN SRPK2 [activation] CTNNB1 PYGO1 [activation] LATS1 NPHP4 [inhibition] SLA GAB1 [activation] GABARAPL2 YWHAE [activation] NF1 DNAJC7 [activation] LAT LCK [activation] PLG HSPB1 [inhibition] DSG1 MAPK7 [activation] RTN1 BCL2L1 [activation] ELN MMP9 [activation] TBC1D3F RAC1 [activation] SRC CSNK2A1 [activation] CASP3 IL18 [activation] MAPK10 ARRB2 [activation] FYN CNTN1 [activation] HTR2C GNAQ [activation] HSPA8 MYC [inhibition] CRIP2 KLF10 [activation] YWHAB TBC1D22B [activation] CDC16 SMAD3 [activation] RUNX1 JUN [activation] LIG3 ABL1 [activation] PRKDC ABL1 [activation] 页 383 共 454


2016/4/8 19:15

CUL1 HSPA6 [inhibition] CRK CNTFR [activation] PTPN1 GHR [activation] RASSF4 STK4 [activation] SPDYA CDK2 [inhibition] STK4 RANGAP1 [activation] MAST2 YWHAE [activation] SLC6A9 PRKCA [activation] ADRBK1 CCR4 [activation] NR1H3 BARD1 [activation] PRKCB VTN [inhibition] NUDC VCAM1 [activation] PRKDC TRADD [activation] CD247 DOCK2 [activation] MAGEA1 SELPLG [activation] TP53BP1 PLK1 [activation] APP CCND3 [inhibition] CDKN2AIP BARD1 [activation] RAD21 MCM2 [activation] ESR2 ARPC2 [activation] HIST1H2AG IL33 [activation] PRPF38A SRPK1 [activation] TRAK1 MYC [activation] TUB LCK [activation] SEMA3F NXF1 [activation] TAB2 IRAK1 [activation;inhibition] TIAM2 H2AFX [activation] CCDC36 FANCL [activation] NOS3 CDC37 [activation] TXN2 TIFA [activation;inhibition] SSX2IP GEM [activation] CTNND1 ATF2 [activation] CCAR2 CCNA1 [inhibition] ITGA4 LARP1 [activation] NOTCH2NL TNIP3 [activation] DDX58 TMEM173 [activation] KCNB2 KCNV1 [activation] TRAF5 MDM2 [activation] LRP1 DAB2 [activation] TLK1 NBN [activation] MASP1 RPS6KA3 [activation] FBXO6 PLXNB2 [activation] POU5F1 MNAT1 [activation] RPS6KA6 HSP90AB1 [activation] TP53 BRD8 [activation] CTNNB1 CCNE1 [activation] SIRT3 MAP2K5 [activation] DERL1 SHH [inhibition] TIMP3 MMP14 [activation] LRRK2 LGALS8 [activation] MCM3 PAK2 [activation] MAPK14 AES [inhibition] SMARCB1 KMT2A [activation] PUM1 EGFR [activation] NGFR TRAF2 [activation] PRKCA ATP1A1 [activation] CRK PCDHA1 [activation] PPIF SLC25A4 [inhibition] ARF4 ADRB2 [activation] ASB2 SKP2 [inhibition] HSPB1 TGFB1I1 [activation] CDK11B YWHAG [activation] KRT31 CRH [activation] CUL1 ENO2 [activation] CD79B CD3E [activation] RANBP9 SMAD2 [activation] MAP3K3 HSPA1L [activation] USP7 PTEN [activation] YWHAE DYRK1A [activation] SMC2 TNFRSF10D [activation] FANCG ERCC4 [activation] ICAM1 CSNK2A1 [activation] ERCC4 GTF2H1 [activation] RALA HRAS [activation] NGFRAP1 MIF [activation] RGS2 LIG1 [activation] 页 384 共 454


2016/4/8 19:15

H2AFX TSSK6 [activation] CAPN1 ECT2 [activation] BMI1 ACACA [activation;inhibition] MYL6 MLH1 [activation] CD28 DOK1 [activation] RAB25 ITGB1 [activation] EGLN3 EGLN1 [activation] TNFRSF4 TRAF2 [activation] CDC42 MAP3K4 [activation] KIAA0930 YWHAB [activation] PTX3 C1QA [activation] KDM6A POU5F1 [activation] PTRH2 PTK2 [activation] TP53 SNRPN [activation] SUMO3 NBN [activation] MOK WDR18 [inhibition] FHL2 SPHK1 [inhibition] EIF4A3 SMG1 [activation] MYC ACOT8 [activation] LRRK2 CSNK1A1 [activation] NUDC POC1A [activation] SKP2 NUDCD3 [inhibition] PTPRG WAS [activation] PRKCI IKBKG [activation] DTX1 CRK [activation] CTNNA1 UBE2I [activation] DOK1 DOK2 [activation] EXTL1 GRB2 [activation] HDAC1 SMARCB1 [activation] LRRK1 VAPA [activation] GABARAPL2 MARS [activation] UBTF LEF1 [activation] CAMK2A CDK5R2 [activation] CTNNBIP1 PNMA2 [inhibition] ANXA1 FLOT2 [activation] RIMS3 ZDHHC17 [activation] ELMO2 RHOG [activation] FAM84B FGFR4 [activation] AJAP1 MYC [activation] CDC5L ACTR2 [activation] ITGA9 ITGB1 [activation] AGER HMGB1 [activation] APP PSEN2 [activation] WIZ CDKN1A [activation;inhibition] KCNQ2 KCNQ1 [activation] KIAA0408 YWHAG [activation] PPP1R3B IFNAR2 [activation] ROBO1 MAPK14 [activation] MT2A GPR50 [activation] DNM2 EGFR [activation] TRAF2 HSPA8 [activation] FGFR3 EPHA4 [activation] BACH1 NBN [activation] ARID1A GATA1 [activation] STX4 NAPA [activation] APBB1 NOTCH1 [activation] SEMA4F NRP2 [activation] PVR TNFRSF12A [activation] GNAI3 CCDC88C [activation] CSNK1G1 LRRK2 [activation] CD7 NFKBIA [activation] TP53 KMT2E [activation] RELA ACTG1 [activation] MAP1LC3B HSPA7 [activation] DSTN ACTG1 [activation] CSK LILRB1 [activation] NRP1 TGFBR2 [activation] PLCG1 SH2D2A [activation] RELA CARM1 [activation] HACE1 RAC1 [activation] DSG2 PSEN1 [activation] DRD5 GNAZ [activation] FANCC SRC [activation] CFL2 STK11 [activation] SRPK1 ASAH1 [activation] NIN PIAS1 [inhibition] 页 385 共 454


2016/4/8 19:15

ERBB2IP MYC [inhibition] MYC DCLK1 [activation] SMARCA5 NOTCH1 [activation] CDC7 CDK9 [activation] RDX ICAM2 [activation] PAXIP1 MT2A [activation] PRPF6 CTNNB1 [activation] YY1 SMAD2 [activation] LTA LGALS2 [activation] SMAD3 GLI3 [activation] ACTB H2AFX [activation] BID ZHX1 [activation] FSTL1 BMPR1A [activation] RASA1 PTPRC [activation] MAPK9 DUSP19 [inhibition] SH3D19 GRB2 [activation] PHACTR4 CALM1 [activation] SRPK1 PHF7 [activation] KAT2A EP300 [activation] TBRG4 AGTRAP [activation] MAPK12 EEF2K [activation] PTPN11 INSR [activation;inhibition] DLG3 NLGN3 [activation] HRAS CDC25C [activation] MMP14 SDC1 [activation] ITGA4 DNM2 [activation] PIK3R1 SCG2 [activation] ESR1 CBLL1 [activation] BTRC CDK1 [activation] TNFRSF10B ARAP1 [activation] LRRK2 PLEC [activation] CDKN1A CEBPA [activation;inhibition] APC RBM4B [inhibition] PDGFRL HRAS [activation] ARHGEF6 EPHB2 [activation] PYCARD FSTL5 [inhibition] DAZAP2 UBE2E2 [activation] CDK6 DAB1 [activation] TNF RNF8 [activation] AKT2 APPL1 [activation] CDK2 PTP4A3 [activation] MYC ASS1 [activation] GZMA LMNB1 [activation] EGF ERBB3 [activation] CSRP1 EGFR [activation] SOSTDC1 BMP2 [activation] LAMTOR5 MYF6 [activation] ASPSCR1 TACC3 [activation] KLHL26 NUDC [activation] BMPR2 PMPCA [activation] PRKAR2B ARFGEF2 [activation] SLC25A4 GRB2 [activation] NPY MC4R [activation] RAP1A PPP2R1A [activation] FBXL18 NOTCH2NL [activation] RANGAP1 HLA-B [activation] PRKCZ ESR1 [activation] SMCHD1 NOTCH1 [activation] CCNA2 CKS1B [activation] PAK2 GIT2 [activation] STK3 LRRK2 [activation] FLNB CRK [activation] TBRG4 FAM9B [activation;inhibition] NXF1 CDH24 [activation] GABARAP HIST1H4A [activation] CLIP4 CDK5RAP2 [activation] PTPN11 CDH5 [activation] HGS EHMT2 [activation] MLKL ANAPC11 [activation] MCM2 PLK1 [activation] NCOR1 RXRA [inhibition] ARHGEF25 RAC1 [activation] FANCG SPTAN1 [activation] PPM1J CSN1S1 [inhibition] TNF UBE2N [activation] GNAQ PIK3CA [activation] 页 386 共 454


2016/4/8 19:15

SMC5 YWHAZ [activation] PPP2CA PMS2 [inhibition] CYLD DVL1 [inhibition] CALM1 SCLT1 [activation] SLC25A5 GRB2 [activation] POT1 ACD [activation] SMAD2 KIAA1033 [activation] ITGB1 TGFB1I1 [activation] COL4A4 MMP9 [activation;inhibition] TGFB1I1 TGFBR2 [activation] BTK BCL2L11 [activation] RCAN1 TRAF6 [activation] PARD3 RASSF9 [activation] PCK1 NUP62 [activation] PAXIP1 EPB41L3 [activation] ICT1 MRPS27 [activation] GRB7 PDGFRB [activation] PVR PVRL3 [activation] IRS2 UBTF [activation] CDK18 NTPCR [activation] MYC MRPL53 [activation] BLNK CD79A [activation] GRN TOP3B [activation] ALK JAK3 [activation] MRPL40 STK3 [activation] RABGGTA BMPR2 [activation] PPARA RXRA [inhibition] AMMECR1L SRPK1 [activation] PPP2R1A RAB18 [activation] LHX2 CITED2 [activation] SNW1 EIF2S2 [activation] AR RANBP9 [activation] TP53 PNP [activation] USP7 RPA3 [activation] EIF1B DVL2 [activation] GNAQ RGS5 [activation] FYN FLT1 [activation] BAMBI SMAD7 [inhibition] LPL CETP [activation] BLM RAD51D [activation] ITGA5 CBL [activation] COL4A6 MMP9 [activation;inhibition] PRKD2 HSP90AB1 [activation] LRRK2 CUEDC1 [activation] PRKDC GRB2 [activation] PPP2R1A OBSL1 [inhibition] ARHGEF6 SMAD1 [activation] GRB2 CDKL5 [activation] BRAP UBE2H [activation] SNAI1 KRT40 [activation;inhibition] TRRAP MYC [activation] AIRE H2AFX [activation] ITGB4 FYN [activation] PTEN RANBP1 [activation] CDC23 SOX2 [activation] IL7R LYN [activation] BUB1 SFRP4 [activation] NFKBIZ STAT3 [activation] GPRASP2 CHRM1 [activation] CDK11A CDC37 [activation] RPA1 MSH4 [activation] ZBTB16 TIMP1 [activation] CCDC8 GCN1L1 [activation] CDC5L DIXDC1 [activation] NXF1 IGF2BP1 [activation] SRPK2 GABARAP [activation] NOTCH1 PPP2R2A [activation] TRIM24 TAF1B [activation] ESR1 WHSC1 [activation] SOX2 FAM21B [activation] TIAM1 ABCA1 [activation] EFEMP1 NOS3 [activation] SOX2 SMARCA5 [activation] ARRB2 NFKBIA [activation] BCL2L11 DYNLL2 [activation] GAB2 YWHAB [activation] 页 387 共 454


2016/4/8 19:15

COPA ARFGAP1 [activation] MKNK1 PPP2CA [activation] PPP2R1A TRADD [activation] HLA-B CYCS [activation] CAMSAP1 SMAD1 [activation] GABRB1 NOD1 [activation] MAPK6 SPRR2D [activation] YWHAE ADAM22 [activation] APPL1 KXD1 [activation] FURIN TNFSF13 [activation] TGFB1I1 SH2D1B [activation] RPA2 RAD52 [activation] ITGB1 ITGA4 [activation] SSU72 MAPK8 [activation] KAT2B E2F1 [activation] ABI1 FYN [activation] CD38 CD247 [activation] PDGFB A2M [activation] TSC1 RAB11FIP5 [inhibition] PRKACB ACVR1B [activation] MPP5 LATS1 [inhibition] NCK1 CCR10 [activation] RFX6 STK16 [activation] SRPK1 HSP90AA1 [activation] OBSL1 TTN [inhibition] TYK2 HSPB1 [activation] APP RAB2B [activation] PFN1 YWHAZ [activation] WAS VASP [activation] ETFA ICT1 [activation] PRKDC MBP [activation] KITLG FLT3LG [activation] SNAP25 SCAMP1 [activation] PIAS1 PTPN1 [inhibition] MLLT4 YWHAQ [activation] NINL JUNB [activation] ARRB2 MAP2K4 [activation] CDK6 MSL3 [inhibition] BRD4 RELA [activation] KIAA0196 RPA1 [activation] USP8 SPP1 [activation] CALM1 RYR1 [activation] ARPC1B AURKA [activation] NOTCH2 MAML3 [activation] GCN1L1 CAMKK2 [activation] APP GTPBP8 [activation] ULK1 MBP [inhibition] NRXN1 APBA2 [activation] RER1 EGFR [activation] GNB2L1 ITGB1 [activation] IGF1R GRB10 [activation] CDC6 CDK2 [activation] PASK PIAS1 [inhibition] NR4A1 ERC1 [inhibition] AXIN1 PPP2CA [inhibition] NR2E3 RXRA [inhibition] VCAM1 PGAM5 [activation] SAMHD1 BARD1 [activation] SPRR3 LOR [activation] SOCS1 RASA1 [inhibition] STK11 TP53 [activation] HSP90AB1 RPS6KA5 [activation] CD4 PIP [activation] HIPK3 FAS [inhibition] ANAPC5 PTEN [activation] BLK EFS [activation] RTCB OBSL1 [activation;inhibition] DDX39B WWOX [activation] MYB NGFRAP1 [activation] NOTCH1 SMC1A [activation] CFL1 NRK [activation;inhibition] PRKAG3 PRKAA1 [inhibition] RIN3 FYN [activation] PRR12 PUM1 [activation] EP300 HDAC1 [activation] TGFA ELANE [activation] 页 388 共 454


RPA1 CHMP4A DDX6 CDH1 FGFR1 TJP2 SH3KBP1 CFLAR CD2 CEBPB FBXW11 ANAPC11 TNF VCAM1 UBASH3B CREB1 PDIA4 LDB1 BARD1 GRB2 DAPK3 TENC1 RAC1 STRAP KPNA2 SMAD7 JUN PTPN11 GH1 FMNL2 YWHAB RELA MYC C1QTNF2 C4BPB PDGFRL COPS6 SKIL YWHAZ ATR SMG5 CDH1 IL13 RPA2 MAPK7 CASP8 IQGAP1 E2F6 YWHAZ PRKACA PDP1 ACACA MYC RIC8B PML CASP7 FZD10 RHOC BARD1 DVL1 NR3C1 CCHCR1 CNTF AKT1 YWHAE ITPR3 LYN SH2D1A DAPK1 MACF1 JUNB LEPR MDC1 ATF4 CDKN1C TAF1

2016/4/8 19:15

RAB6B [activation] ETS1 [activation] SRPK2 [activation] ANAPC7 [activation] ATG5 [activation] NR3C1 [activation] PIK3R1 [activation] FAS [inhibition] PTPRC [activation] CAMK2A [activation] EEF2K [activation] E2F1 [activation] HSPB2 [activation] HNRNPAB [activation] ARAP1 [activation] EP300 [activation] MDM2 [activation] ISL1 [activation] FKBP3 [activation] RIMS1 [activation] GRB2 [activation] MET [activation] PARD6B [activation] EIF1B [inhibition] SRPK1 [activation] PARD3B [activation] BCL6 [activation] TEK [activation;inhibition] C12orf23 [activation] APP [activation] PARD3 [activation] CEBPD [activation] IQGAP2 [activation;inhibition] NCALD [activation] PROS1 [inhibition] MAPKAPK3 [activation] PRIM1 [activation] SETDB1 [activation] TNK1 [activation] SNW1 [activation] TP53 [activation] BOC [activation] IL4 [activation] MCM3 [activation] PTPRR [activation] ERRFI1 [inhibition] ARF6 [activation] KMT2A [inhibition] IRS1 [activation] MIP [activation] PRKCD [activation] EEF2K [activation;inhibition] RARS [activation] GNAS [activation] MAPK3 [activation] IKBKE [activation] HILPDA [activation] MCC [activation] ATP1B1 [activation] BUB1 [activation] FTH1 [activation] FSD2 [activation] VHL [activation] CSF2RB [activation] IGF1R [activation] OBSL1 [inhibition] MME [activation] FYB [activation] CALM1 [activation] SOX2 [activation] ATF2 [activation] CSNK2B [activation] GATA4 [activation] CREBBP [activation] LIMK1 [activation;inhibition] MSX1 [activation] 页 389 共 454


2016/4/8 19:15

EIF2B3 EIF2B5 [activation] SH3GLB2 UBA5 [activation] PEBP1 MAPK1 [inhibition] CDC42EP4 RHOQ [activation] DDX58 MBP [activation;inhibition] EVL ZDHHC17 [activation] BRIX1 CD48 [activation] TRAF3 TLR3 [activation] AKAP6 GRB2 [activation] METTL2B PSEN1 [activation] MMAB ICT1 [activation] MYC BAHCC1 [activation] GIT1 RAN [activation] LRRK2 MAP2K4 [activation] CASP4 SNRNP200 [activation] PLK1 CLIP1 [activation] RUNX1 TRAF6 [activation] MAP2 FYN [activation] NOTCH2NL LCE1B [activation] FBXO6 POMGNT2 [inhibition] ANKRD18A YWHAZ [activation] CD40 TRAF2 [activation] CEACAM1 EGFR [activation] GDF9 DLEU1 [activation] CCL11 TPI1 [activation] CALM1 LUC7L [activation] MYC CTNND1 [activation] AR VAV2 [activation] PRRC2C NR3C1 [activation] MAPT CASP3 [activation] NXPH1 NRXN1 [activation] HDAC1 NFYC [activation] APBB1 FASLG [activation] YWHAE KIAA0232 [activation] EIF3H ICAM1 [activation] BRCA1 SP1 [activation] RPS6KC1 ETS1 [activation] AURKA HIST3H3 [activation] ARHGEF2 YWHAZ [activation] EIF2AK4 ARRB2 [inhibition] CD93 F12 [activation] USP47 BTRC [activation] RRP1B MYC [activation] CDK6 TGFBR1 [inhibition] RGL2 RAC1 [activation] SKIV2L EGFR [activation] CASP3 NFE2L2 [activation] PIK3R1 TGFBR1 [activation] FMNL1 LSP1 [activation] HSP90AB1 MYLK4 [activation] RAP1GAP MAPK6 [activation;inhibition] CRK XPO1 [activation] TRMT10C EGFR [activation] TGFB2 DCN [activation] LRRK1 BCR [activation] MAPK14 ATG9A [activation] PARP2 H3F3A [activation] ASAP1 PTK2 [activation] MET SH2D1B [activation] KLK2 SERPINF2 [activation] YAP1 AXIN1 [activation] GDI2 RAB11A [activation] SLX4 IGLC1 [activation] CAMSAP3 GSK3B [inhibition] FGFR1 CREBBP [activation] BMPR1B ARHGEF6 [activation] EDN1 UBQLN4 [activation] PLK1 CALML5 [activation] KCNJ8 KCNJ2 [activation] DFFA YWHAZ [activation] CALM1 IQGAP3 [activation] DDX5 NCOA2 [activation] EP300 HMGN1 [activation] CASP3 PARG [activation] CSF2RA CHUK [activation] ILK SNRNP35 [activation] 页 390 共 454


2016/4/8 19:15

RAD21 CAPN1 [activation] MDM4 TP73 [activation;inhibition] MAPKAPK5 HSPB2 [activation] RB1 CHEK2 [activation] CMTM5 AACS [activation] NFASC NCK1 [activation] CACNA1A C9orf169 [inhibition] FASLG EPS8L3 [inhibition] YWHAB SRGAP2 [activation] HAUS5 ILK [activation] MCC RPS6KA3 [activation] MAML2 CREBBP [activation] EIF1B G3BP2 [activation] PRKCZ CSNK2B [activation] TP53 SYVN1 [activation] ITGA4 PICALM [activation] STOML3 CAV1 [activation] GRB2 ZKSCAN3 [activation] SHB PIK3R1 [activation] B2M HLA-B [activation] HRAS IL3 [activation] ADRB2 HTR4 [activation] DHX37 WHSC1 [activation] PPP2CB MLH1 [activation] CDKN1B RPS6KA1 [activation;inhibition] E2F1 YWHAQ [activation] RANGAP1 CCL5 [activation] ATF3 IGSF21 [activation] CORO1B SSH1 [activation] PRKACA VTN [activation;inhibition] DLGAP4 ESR2 [activation] SMURF1 MAP3K2 [inhibition] RBL2 DYRK1A [activation;inhibition] RABAC1 RHOA [activation] E2F1 TFDP1 [inhibition] MLH1 ASS1 [activation] MRM1 ICT1 [activation] PLD1 EGFR [activation] SORT1 NTRK3 [activation] CDK5R1 CDKN1B [activation] BARD1 HSPA14 [activation] MON2 TNFRSF1A [activation] PPP2R1A IKBKE [inhibition] LUC7L2 NFYA [activation] RAPGEF2 CTTNBP2 [activation] LIG1 CDK2 [activation] RPS6KA5 SMAD6 [activation] MAPK1 PPID [activation;inhibition] RAB31 MPP3 [activation] WNK1 SIMC1 [activation] NUP43 NUP37 [activation] YWHAH ZBTB17 [activation] CTTN MCM7 [activation] EHMT2 WIZ [activation] RPA3 ACTBL2 [activation] DNAJA1 CDC16 [inhibition] GRB2 GSTM1 [activation] SHC1 IRS2 [activation] ITPKA ITSN2 [activation] TGFBR1 ITGA5 [activation] COL1A2 MMP9 [activation] RPS17 ARRB2 [activation] GAPDH CDK17 [inhibition] UBE2E2 RNF166 [activation] HSPA2 APP [activation] MAPK14 PTPRR [activation] EIF4A2 MYO1C [activation] EHMT1 MPHOSPH8 [activation] MDM2 ANXA2 [activation] PNMA1 PRKCI [activation] SH2D1A SLAMF1 [activation] PTEN CTNNB1 [activation;inhibition] HSFY1 AIF1 [activation] PRKCD PPP2CA [activation] KAT2B NCOA1 [activation] GSK3B FAM83D [inhibition] 页 391 共 454


2016/4/8 19:15

WNK2 YWHAZ [activation] ST8SIA4 NCAM1 [activation] OSMR IL6ST [activation] NBN PIK3CB [activation] ELANE SERPINF2 [activation] CAV1 TRAF6 [activation] CASP8 KLK9 [inhibition] HUWE1 STMN1 [activation] APC FANCC [activation] PPP3CB TBC1D10C [activation] TRPV4 PACSIN2 [activation] KRT40 SEMA4C [activation] SMARCB1 RB1 [activation] NUDC LRWD1 [activation] CDH5 CSK [activation] HIF1A CAPN1 [activation] ATF2 CYCS [activation] EIF2S1 EIF4G2 [activation] PPP2CA CTDP1 [inhibition] WDTC1 DDA1 [activation] EPB41 MIF [activation] TXLNA HYPK [activation] SDF2 EGFR [activation] TRAF3 TROAP [activation] QARS STK3 [activation] SMAD2 RASL12 [activation] YAP1 GSK3B [inhibition] HMGN1 YWHAZ [activation] EIF4EBP2 EIF4E [inhibition] ABCA1 PRKACA [activation] GAB2 PLCG2 [activation] RPS6KA3 CSNK2B [activation] PLK1 CDC6 [activation] KPNA2 GRB2 [activation] RAD17 FOXO3 [inhibition] BCL2L11 GIMAP5 [activation] ITGA4 BOLA2 [activation] SPERT EIF4E2 [inhibition] TRAF6 CYB5B [activation] NUP133 MYC [activation] GNB5 RPA1 [activation] ATR ARHGEF1 [activation] HTR2A JAK2 [activation] RAP1GAP GNAZ [activation;inhibition] RAN HERC5 [activation] NOS3 EFEMP2 [activation] SBK1 FCHSD1 [activation] IKBKAP CHUK [activation] MMP1 TIMP1 [activation] CD86 CD80 [activation] CDH2 NAA25 [activation] FBXW8 TP53 [activation] LUC7L2 PTN [activation] CDC5L STK24 [activation] MCM3 RPA1 [activation] PPP2R1A CDK1 [activation] BTRC CLSPN [activation] GPRASP1 CHRM3 [activation] HLA-B SEC23A [activation] COA1 STK4 [activation] SMAD3 SOX9 [activation] CHEK2 ATR [activation] LRRK2 ARPC1B [activation] XIAP RAC1 [activation] PPP1R12C CACNA1A [inhibition] EEA1 RAB22A [activation] IRAK4 IKBKG [activation] MDC1 ANAPC1 [activation] CAV1 FAS [activation] BARD1 SNRNP70 [activation] SHC1 MME [activation] NPIPA1 FOS [activation] MDM2 ANXA11 [activation] SDCCAG8 TSC1 [activation;inhibition] TRPV1 CALM1 [activation] VRK2 MAPK8 [activation] 页 392 共 454


2016/4/8 19:15

BLM RAD51 [activation] LCP2 HCK [activation] CIAO1 EIF4G2 [activation] ATG12 TGM3 [activation] CRYAB BCL2L1 [activation] SERPINA5 EP300 [inhibition] OTUD5 TP53 [activation] SAV1 IGF2BP2 [activation] NR4A1 CD2AP [inhibition] SRPK2 ENOX2 [activation] BAAT MUTYH [activation] TRIP10 LYN [activation] RPA3 KIAA1033 [activation] MPRIP GRB2 [activation] FES JAK1 [activation] VCAM1 GMPS [activation] TRAF6 ARRB2 [activation] MYC NEK9 [activation] FBXO5 ANAPC1 [activation] MIF TNFRSF10D [activation] SUV39H1 EP300 [activation] SERPINE2 FAM9B [inhibition] PAK2 ARHGEF6 [activation] EPB41L3 EIF4A3 [activation] VTN TNFRSF11B [activation] SHC1 FASN [activation] APP CEACAM6 [activation] ATM BRAT1 [activation] CRX EP300 [activation] SRPK1 NKAP [activation] SEMA3F NRP2 [activation] GATA1 TRIM25 [activation] TNRC6B CTNNB1 [activation] PARD6A RICTOR [activation] APP EIF5 [activation] MDM2 CSNK1A1 [activation] CHGB SGK223 [activation] SRPK2 ARL6IP4 [activation] YWHAE YAP1 [activation] REL EIF4E2 [inhibition] ITGAV ITGB1 [activation] PTAFR CALM1 [activation] CRKL GRN [activation] KRT18 CASP7 [activation] NCOA2 TP53 [activation] EBNA1BP2 SRPK3 [activation] REL GRB2 [activation] FOS TCL1A [activation] LYN CASP7 [activation] PIAS1 DDX21 [inhibition] OGG1 ERCC6 [activation] PPARA CEP350 [activation] NIPSNAP1 CDH1 [activation] GTF2H3 RPA3 [activation] SPRY1 SOCS4 [inhibition] PDGFRB VAV1 [activation] DYSF GNL3 [activation] FERMT3 VCAM1 [activation] SPP1 PRKCA [activation] SKP2 BARD1 [activation] PRKCZ PPP3CA [activation] PLD1 ACTG1 [activation] CDK1 PRKCB [activation] E2F1 ESR1 [activation] KAT2B CIITA [activation] TSNAXIP1 HSPB1 [activation] ICAM1 TUBE1 [activation] SRSF5 BARD1 [activation] GPATCH2L TULP3 [activation] STAT5A IL7R [activation] HIST3H3 TRPM7 [activation] APP GABARAPL2 [activation] UBE2V1 XIAP [activation] HIST3H3 EIF4A3 [activation] PRKCD YWHAB [activation] LYN CTLA4 [activation] 页 393 共 454


2016/4/8 19:15

CBLB CD2AP [inhibition] MAVS TICAM1 [activation] SPP1 APOA1 [activation] GRIA1 GRIA2 [activation] MYCN MAX [activation] KMT2A AR [activation] CBL PTK2 [activation] EIF2S1 CASP6 [activation] MORC3 SUMO3 [inhibition] THRB CCND1 [activation] IQGAP1 OBSL1 [inhibition] PPP1R32 APP [activation] TELO2 RPTOR [activation] DSG1 CFTR [activation] HIST1H4A RPS6KA5 [activation] MYO1C RPA2 [activation] AVPR1B PRKCA [activation] TP53BP1 CCNB1 [activation] BIRC3 TNF [activation] RAN PTMA [activation] CACNA1S RYR1 [activation] DRD5 GNA12 [activation] FYN NKX2-1 [activation] ICAM1 EZR [activation] SH3GLB2 STK4 [activation] VAV3 GAB1 [activation] TNFSF15 TNFRSF25 [activation] PIN1 RARA [activation] BRAF SGK1 [activation] FYN JAK2 [activation] PGAM5 CCDC8 [inhibition] PRKD1 ABL1 [activation] EIF4G2 CDC5L [activation] CDK2 CDKN1A [activation;inhibition] CALM1 GP6 [activation] PRKAR1A MAPT [activation] PPP2R5B IER3 [activation] TICAM2 PRKCE [activation] SPP1 PARP1 [activation] BTRC CRY2 [inhibition] ARL6IP4 SRPK1 [activation] SMARCA1 SETD1A [activation] STX7 MAPK6 [activation] CAMK2G TIAM1 [activation] MAP1LC3B PRKDC [activation] CDKN1A INPP5K [activation] ERBB3 CSK [activation] HTRA1 NOS3 [inhibition] GRB2 TTYH2 [activation] VTN APP [inhibition] FANCC RB1 [activation;inhibition] TP53 PPP2R2A [activation] STAMBP MAP3K2 [activation] CREB5 FOS [activation] TP53 COLGALT1 [activation] PAXIP1 SCAMP5 [activation] ERBB2 PGR [activation] HAND1 PRKACA [activation] CSK SHC1 [activation] SCGB2A2 CASP8 [inhibition] SMS RPS6KA3 [activation] EZR CAPN6 [activation] CDK4 DUSP9 [inhibition] PML MDM2 [activation] IRS4 RELA [activation] DDX11 PFN2 [activation] SH2D2A AR [activation] GAD1 JUN [activation] FBXW11 MAST3 [inhibition] ITGA4 PNP [activation] PAK1 MYNN [activation] IL7R HNRNPA0 [activation] ITGA4 EIF4G2 [activation] CDK4 FKBP5 [inhibition] MRE11A CDC5L [activation] SYK FGR [activation] 页 394 共 454


2016/4/8 19:15

CACNA1E HSPA1A [inhibition] CDK7 RPA1 [activation] SOS2 LOX [activation] PPP1R2 GSK3B [activation;inhibition] MAPK14 MUC12 [activation] GUSBP1 TP53 [activation] MAP3K1 DYRK1A [activation] USP11 NOTCH1 [activation] CFL1 ACTB [activation] CRK CNTNAP1 [activation] CLIP3 CYLD [inhibition] NDP LRP5 [activation] EPS8L2 PTK2 [activation] SOS1 EPS8L2 [activation] CBL BLNK [activation] LRRK2 CAMK1D [activation] MCM3 MCM7 [activation] CDC5L EXOC1 [activation] CCHCR1 HSPB1 [activation] YWHAZ TGFBR1 [activation] GRB7 AGAP1 [activation] CHEK2 ENO1 [activation] KPNA2 TP53 [activation] PPP2R2D MLH1 [activation] IRF7 P4HA1 [activation] RANBP9 ITGAL [activation] KMT2A PSIP1 [activation] BUB3 WBP4 [inhibition] CASP3 VAV1 [activation] CRK CORO1C [activation] ITK ERBB3 [activation] PRNP PPP1R14A [activation] OGT SNAP29 [activation] TRAF3IP1 TRAF6 [activation] APP RPS6KB1 [activation] HSPBP1 HSF1 [activation] FBXO6 SCARB1 [activation] KIAA0922 MYC [activation] AP2S1 GRB2 [activation] MDM2 HDAC1 [activation] NOD1 CASP8 [activation] CTDSP2 SNAI1 [activation] PLEK ACVR1 [activation;inhibition] SRPK1 PCBP1 [activation] SP1 CEBPB [activation] IQGAP1 APC [inhibition] MAP1LC3B ULK1 [inhibition] GC PIK3R3 [activation] SRF CRIP2 [activation] ROPN1 PRKAA1 [inhibition] XPO7 MYC [activation] PTTG1 CAMK2A [activation] NR1H4 EP300 [activation] DYRK1A SRSF4 [activation] SP3 E2F1 [activation] DNAJB1 PSEN2 [inhibition] YWHAZ PPFIBP1 [activation] SKP2 CDK3 [activation] EGFR SUSD1 [activation] PAX6 SOX10 [activation] AGT AGTR2 [activation] NUP62 KLHL32 [activation] GH1 RPS19 [activation] SRC CBLL1 [activation] IFNAR1 EP300 [activation] GOLGA2 ARPC3 [activation] XPO1 EPAS1 [activation] MAP2K1 HLA-B [activation] PPP6C MYC [activation] FBXO25 IL21 [activation] CCNE1 BTRC [activation] HSPA9 EGFR [activation] FSTL1 BMP2 [activation] GP1BB GP9 [activation] SEC31A APC [activation] TP53 MRPS23 [activation] 页 395 共 454


RELA IRF2 NAA11 HIF1A EHMT2 CTNNA3 CSNK2B NRBP1 AURKA TBC1D2 XBP1 HIF1A FYN NMT1 MRPL10 EGFR MYOD1 STAT3 UBE2I TP53 HSPB1 CAMK1 C8orf33 TAOK1 SH3BP5L YWHAB RPS6KA3 SHANK1 PIK3R1 NCL CDC14A CHRM1 RHPN2 RHOA AIRE SRC MDM2 NOTCH4 TP53 SF3B2 CKAP4 MYC CARM1 CEBPB JAG1 CANX EPOR MAPK3 GATA1 RAI1 PIK3R1 FCGR2A ADCY2 ADCY5 NFKBIA PTPN1 GCN1L1 MAGED1 YAP1 TP73 MAP2K1 PARVA SPP1 TMEM168 FGD2 TMEM239 ANK1 NFASC VCAM1 SARS CACNA1A MOAP1 TAB1 GIT1 PXN CASP3 BID TUBB2B TIAM1 CSNK1E PPP1CC ARFGEF2 ESR1 MYL6 TRAPPC13 MGAT5B CAMK2B EGFR FHL2 CRKL DOK1 GDF9 ORAI2 CTNNA1 PARD3 EZH2 JAK2 CRTC2 RFWD2 SGTA NXF1 MYOZ1 PPP3CA ABL1 FOS ADRB2 EIF2B1 ILK LIMS1 STAT3 STK4 PEX19 IL23A FCGR2C PLCG1 DEF6 RAC2 WIPF1 ZAP70 CHRM1 GPRASP1 NR1H2 FOXO3 CD5 ZAP70 CDC37 A2M RANBP10 RAN IGF2BP1 IFIT1 DAB1 APP RPS6 MTOR RGS17 DHX37 TGM1 BMI1 ANXA2 CDC42 PTPN23 GRB2 POLR2A CTR9 EIF3D ETS1 GAB1 PDGFRB NKX2-1 GRB2

2016/4/8 19:15

[activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] TRAPPC8 [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 396 共 454


ITGA4 OS9 MPRIP VCAM1 TSC22D1 RALGDS BMPER PDGFRA STRADA FAM83B OPRK1 TBP CNTFR ANKZF1 RAPGEF3 EGFR DAAM1 GRB2 RASGRF1 INS HOXC6 A2M NAA10 SOS1 LPA OGT GLI1 CDH1 PVRL2 SKIL CD160 MEF2A IL11 EGFR ACTA1 PAXIP1 TP53BP1 ATF2 FYN MYL9 GABARAP AFF1 STK4 SMAD2 COL4A6 CRADD MDM2 BRCA1 PDGFRA RTN3 SELPLG EXOC8 LDOC1 EIF4A2 SHISA5 MAPK6 ACOT8 HSPA6 ZC3HC1 PVRL2 RPS16 FZR1 SYK ELK1 DDX24 SKP1 CAD HOMER1 H2AFX MAP2K7 MAD2L1 SNAP29 ANXA7 NR2F2 EP300 FANCA

2016/4/8 19:15

RPL26 [activation] DCSTAMP [activation] LRRK2 [activation] TRAP1 [activation] TBRG4 [activation;inhibition] MAPK3 [activation] BMP6 [activation] PDGFRB [activation] CAB39 [activation] CSNK1E [activation] SLC9A3R1 [activation] HSF1 [activation] NCK1 [activation] STAT6 [activation] RRAS2 [activation] MAPKAPK3 [activation] ABL1 [activation] CFL2 [activation] ADRBK1 [activation] MAPK6 [activation] APC [inhibition] IL4 [activation] ARHGEF7 [activation] GAB1 [activation] FGB [activation] TRAK2 [activation] CDK4 [inhibition] ACTR3 [activation] MDFI [activation] SNRNP70 [activation] MDM4 [inhibition] MEF2D [activation] MAGEA11 [activation] KCTD9 [activation] CTNND1 [activation] DKC1 [activation] MAPK3 [activation] EEF1D [activation] GPR63 [activation] TP73 [activation;inhibition] ATG5 [activation] RELA [activation] RASSF3 [activation] CITED2 [activation] SERPINE2 [inhibition] KCTD9 [activation] HSPB1 [activation] NFKB1 [activation] STAT5A [activation] FGFR1 [activation] SELL [activation] ULK1 [inhibition] ATF4 [activation] MYO1B [activation] TP53 [activation] ARPC3 [activation] ISG15 [activation] NFKB1 [activation] MAPK1 [activation] PVRL3 [activation] RELA [activation] SKP2 [inhibition] CD72 [activation] MAPK1 [activation] WHSC1 [activation] FBXO27 [inhibition] RIPK1 [activation;inhibition] GRM1 [activation] CALM1 [activation] DUSP19 [inhibition] DAXX [inhibition] IGF1R [activation] PLD3 [activation] PIAS1 [inhibition] RAN [activation] GNB2 [activation] 页 397 共 454


2016/4/8 19:15

DCTPP1 HLA-B [activation] PSEN2 BCL2L1 [activation] SMURF1 SASH3 [inhibition] ATM ATMIN [activation] MEOX2 NTF3 [activation] PARD6A PRKCI [activation] EIF2AK2 PPP2R5A [activation] FXYD1 ATP1B1 [activation] NR0B2 EHMT2 [activation] SRPK2 GPR114 [activation] FOXA2 MIP [activation] ZC3H7A STK3 [activation] FBXO6 DNAJC11 [inhibition] BMPR1B BMPR2 [activation] ZC3H7A PAK1 [activation] PTBP3 RPRD1A [activation] RAN RGPD5 [activation] CDH2 CTNND2 [activation] CHRNA2 CHRNB4 [activation] UGT1A1 UGT1A9 [activation] PI4KA CD4 [activation] LCK ESR2 [activation] APP CDK5 [activation] ACVR1 RRAS2 [activation] SUDS3 SRPK1 [activation] LAMTOR4 RRAGC [activation] PML EIF4E [inhibition] SHB FGFR1 [activation] MAPK3 STMN2 [activation] EIF3D HLA-B [activation] BIRC2 TRAF6 [activation] POLR2B MYC [activation] PALB2 PDS5B [activation] HSPA8 CD40 [activation] SRC YWHAH [activation] PRKCB HIST1H3A [activation] TRDN HRC [activation] HSPA5 MAP3K7 [activation] EP400 FOS [activation] NCAPG NCAPD2 [activation] DLG4 LRP8 [inhibition] PAFAH1B3 SETDB1 [activation] CDK4 PPP2R1B [inhibition] DOK4 INSR [activation] RYR1 S100A1 [activation] KIT PTPRU [activation] MARS MAPK14 [activation] CD19 MAPK1 [activation] TNPO1 NUP214 [activation] ENKD1 RAD54B [activation] MYC MCTP2 [activation] ITSN2 GAREML [activation] CNTFR GRB2 [activation] CAV1 ABL2 [activation] BCL2 NRAS [activation] TTC1 TGFBR1 [inhibition] STXBP1 STX3 [activation] ATF2 IRF2BP1 [activation] CAMK2G CABP2 [activation] SCP2 CAV1 [activation] YWHAE REM1 [activation] RTKN RHOA [activation] PIAS1 ESR2 [inhibition] PCBP2 VCAM1 [activation] IKBKB CSF2RB [activation] CCNG1 TP73 [activation] ITPR1 FYN [inhibition] TNFRSF11A CBL [activation] NUP62 NUP93 [activation] ACVR1B INHBC [activation] BRCA2 BARD1 [activation] BHLHE40 TP53 [activation] SRPK1 CSAG1 [activation] SMAD3 CAMK2G [activation] ARF6 MAT2A [activation] F11R ITGAL [activation] 页 398 共 454


2016/4/8 19:15

HNRNPR LRRK2 [activation] SUV420H1 SMARCD1 [activation] JTB APP [activation] GRB2 KCNH7 [activation] ABL1 BAZ2A [activation] EIF3A ICAM1 [activation] EFS CRK [activation] GPS2 MSH5 [inhibition] RNF165 UBE2E3 [activation] FGFR4 ANGPTL4 [activation] ARHGAP11A NXF1 [activation] GNB2 NR3C1 [activation] CRK DLGAP3 [activation] HSP90AA1 CAMKV [activation] NUDC NWD1 [activation] PRKDC AIRE [activation] CTSG SDC1 [activation] CASP8 PRKCI [activation] CNKSR1 CYTH3 [activation] IL24 SMAD4 [activation] EP300 SOX9 [activation] ERBB2IP PPP1CC [inhibition] FRYL BAK1 [activation;inhibition] FBXW11 OGT [activation] PTPN13 CTNNB1 [activation] TENC1 ITGB1 [activation] HSP90AA1 GNAI2 [activation] SMAD3 YTHDF2 [inhibition] RIMS4 SPP1 [activation] GRB7 RET [activation] PAK1 ACTA1 [activation] RHOQ CDC42BPA [activation] CENPJ CREBBP [activation] SH3KBP1 ARAP3 [activation] PEA15 CASP8 [inhibition] AR FES [activation] VAMP8 ATP4A [activation] GOSR1 STX5 [activation] NR2F2 SMAD4 [activation;inhibition] HLA-C HSPA5 [activation] TOMM70A MAVS [activation] RASL12 BMPR1B [activation] XPO1 BACH1 [activation] RIPK1 HSP90AA1 [activation] GAB1 STAP1 [activation] RANBP1 MDM2 [activation] PRKCA HMGA2 [activation] CYLD SPATA2 [inhibition] GABARAP SRSF10 [activation] PTGES3 TERT [activation] SRPK2 LCE3D [activation] HIPK1 RUNX1 [activation] C21orf2 ATOX1 [activation] SHOC2 APP [activation] YWHAH TNIP3 [activation] SRPX2 PLAUR [activation] TPT1 APP [activation] ROCK1 IKBKB [activation] RANGAP1 URM1 [activation] TP53 RPL27 [activation] CAMK2B COL4A3 [inhibition] EP300 NEDD1 [activation] GNAI2 GNB4 [activation] EDEM1 RHO [activation] SOS1 TNIK [activation] FZR1 CUL1 [inhibition] EGFR ILF2 [activation] CDK2 EP300 [activation] NOTCH1 USP15 [activation] HSP90AA1 GNA12 [activation] RNF219 CD40 [activation] ETV7 RICTOR [activation] SYK IL15RA [activation] SHB SRC [activation] CDK6 NIPBL [inhibition] GRB2 BAZ2A [activation] 页 399 共 454


2016/4/8 19:15

ULK1 AMBRA1 [inhibition] NCAPH SMC2 [activation] ARHGEF2 KSR1 [activation] CBX3 CACNB4 [activation] NUDC WDR60 [activation] F2 ST13 [activation] MECR HNF4A [activation] TP53 CD40LG [activation] NCK1 MAP4K3 [activation] CALM1 KRAS [activation] KIT PLCE1 [activation] SNUPN RAN [activation] ANXA7 KLHL23 [activation] GAPDH SGK1 [activation] FASLG GRAP [activation] ABI1 WASF1 [activation] NRP2 SEMA3C [activation] CTNNB1 CHUK [activation] ACTB RAC1 [activation] GUCY1B3 HSP90AA1 [activation] E2F1 SP2 [activation] APP FAM3B [activation] PHF20L1 HIST1H3A [activation] YWHAE SIK1 [activation] GRB2 POLD1 [activation] DLG2 NLGN1 [activation] PIP4K2C BTK [activation] LCE2A RGS20 [activation;inhibition] GJB3 CNST [activation] MAPK1 SNCG [inhibition] LCP2 GRAP2 [activation] CAMK2G GRIA4 [activation] KRAS IGSF21 [activation] CRK APOL5 [activation] PTPN1 BCAR1 [activation] ADCYAP1R1 ADCYAP1 [activation] CSF1 GAB3 [activation] BMPR2 CRYAB [activation] JUN SIRT1 [activation] PAFAH1B3 PAFAH1B1 [activation] NXF1 TLN1 [activation] USF1 HDAC9 [activation] JAK1 IL4R [activation] ELMO1 RAC1 [activation] SERF1A PIK3R3 [activation] DAPK1 YWHAQ [activation] CCNA2 AKT2 [activation] CAV3 SUMO3 [inhibition] SMAD1 STARD13 [activation] GNG2 RPTOR [activation] SMAD3 FOXO4 [activation] IGHM IGJ [activation] SMARCA4 UBE2O [activation] CD4 EIF3D [activation] PLEKHO1 AKT2 [activation] BRD7 MAGEH1 [activation] PIAS2 IFIH1 [inhibition] UGT1A10 UGT1A3 [activation;inhibition] PTPRJ LEPR [activation] SH2B2 ERBB2 [activation] PLCG1 AKAP2 [activation] TLE1 FOXA2 [activation] MAP2K2 SNW1 [activation] PRKCI MAP2K1 [activation] USP19 HSPA4 [inhibition] KLRK1 TYROBP [activation] CAPZA1 LRRK2 [activation] CAMK2A NR2F6 [activation] PRKG1 VASP [activation] CD9 HBEGF [activation] PTGS2 CTNNB1 [activation] PRKCA ITPKB [activation] RPAP3 MAP3K3 [activation] HSPH1 RELA [activation] PRKDC NBN [activation] TP53 GIGYF2 [activation] 页 400 共 454


PRKCZ PRKCI RAP1B APLP1 MAP2K5 NXF1 ATG5 HSPE1 PPARGC1A MAP2K1 LAMTOR2 TRAF5 RIPK1 PLK1 CDC5L SAMM50 EGFR SUMO3 TP53 VCAM1 CAPZB EIF4G2 MKNK1 CCR5 STAT1 LHCGR CGB SMAD2 SOX9 PLEKHG2 ACTN3 ACTB DAB2 CCNA2 NFYB RGS3 GNA11 GRN CACNA1A CTNNB1 GRIK2 ANK1 L1CAM PTEN TAGLN2 BCL2 CDK1 MYL6B ESR1 TMEM14A LXN SRI SRPK2 HIST2H3A CSF2 SYNCRIP ESRRA KAT2B SRPK1 TAAR8 INADL CRIPT TLR4 LY96 NR1H3 SUV39H1 KMT2A MEN1 FES EGFR ITCH TRPV1 ATM BMI1 SNCA ELK1 TNFRSF11A RHOA PLEKHG2 DKC1 ESR1 CFL1 ROCK1 LTBR DIABLO ANAPC4 PTEN GRB10 CAV1 CHUK PTPN11 E2F3 ITGB1 CAV1 AKAP1 LRRK2 CALML5 ZAP70 ANAPC11 ANAPC4 PAXIP1 CCNA1 TGFB1I1 RELA HMGA2 SARM1 TRAF6 MTNR1A HNRNPA0 HSPA2 NCOA2 GRB2 PRG4 RANBP1 NUPR1 PRKACA RRAD SENP3 CDK6 APP DDX10 ERBB2 NRG1 UBE2E1 F12 MSH4 ABL1 ACTG1 MORF4L2 TFE3 MARS SIGLEC6 LEP LCK NR2F2 PRKDC SRF ABL1 C3 PRKAR1A BCL2L11 CDK1 FBXO6 CDC42 FICD HMGB1 MAPK1 PTPRC GRB2

2016/4/8 19:15

[activation] [activation] [activation] [activation] PPARG [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] H2AFX [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] FHL2 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] 页 401 共 454


2016/4/8 19:15

YWHAG FARP2 [activation] NDEL1 DIXDC1 [activation] FHL2 HAND1 [activation] FGF12 MAPK13 [activation] DLGAP1 PIK3R1 [activation] GATA4 MAPK1 [activation] VCAM1 ITGAD [activation] SIRT1 ESRRA [activation;inhibition] TSC22D3 RELA [activation] ACTR3 OBSL1 [activation] LYN DOK3 [activation] STX7 ATP4A [activation] LMNB1 EGF [activation] ASAP2 GRB2 [activation] IFRG15 FBXO6 [inhibition] HIST1H4A LRWD1 [activation] WAS PIK3R1 [activation] COL1A1 DCN [activation] PKM CTNNB1 [activation] PCK1 IKBKG [activation] MACF1 CNTNAP4 [activation] VCAM1 RPL26 [activation] RIPK1 PGAM5 [activation] YWHAG PRMT5 [activation] DSG3 FURIN [activation] ITPR1 BCL2 [inhibition] FBXW11 NFE2L2 [activation] CTNNB1 CDC27 [activation] MAPK8 JKAMP [activation] DDX54 SEMA4A [activation] CDK2AP2 A2M [inhibition] ARF1 FBXO6 [activation] L1CAM RABGEF1 [activation] CDH1 HSPA8 [inhibition] SCAP VCAM1 [activation] CASP3 HIP1 [activation] CD81 HNRNPD [activation] PNISR APC [inhibition] PPARA UBE2I [activation] DDA1 AGTRAP [activation] ANKRD2 TCAP [inhibition] SETDB1 PML [activation] GABARAPL2 SRSF10 [activation] CREB1 PRKG1 [inhibition] FGFR3 BORA [activation] SMC2 HLA-A [activation] EGFR CNTN2 [activation] DCBLD2 FYN [activation] ERBB3 CRKL [activation] TRAF3 RIPK2 [activation] SRC SOS2 [activation] TGFB1 ENG [inhibition] MAP3K12 HSP90AB1 [activation] MET PLXNB1 [activation] CTNND1 NANOS1 [activation] NFE2L2 MAPK8 [activation] SKP1 PPP1CC [inhibition] PRMT1 FGF2 [activation] CA9 XPO1 [activation] CAD NFKB1 [activation;inhibition] APC LAMA4 [activation] GAB1 SH2D1B [activation] CYLD PLK1 [inhibition] MRPL39 ICT1 [activation] SIMC1 YWHAZ [activation] EFHC2 MAPK9 [activation] SMAD3 TGFB1I1 [activation] CAMK2B GAPDH [inhibition] TP53 SAE1 [activation] NCOR1 CDKN1A [inhibition] FYB SELH [activation] BRK1 NLGN4X [activation] EGFR IQGAP1 [activation] CHN2 RACGAP1 [activation] DNAJC8 SRPK2 [activation] CDK5RAP2 SENP2 [activation] 页 402 共 454


2016/4/8 19:15

PRNP APLP2 [activation] L1CAM RDX [activation] DLGAP2 NLGN4X [activation] HCK C2orf44 [activation] CDKN2C NIF3L1 [inhibition] BCL3 NFKB1 [activation] PLCB3 KRIT1 [activation] TMEFF1 PTPRJ [activation] GRB2 HTT [activation] FAM195A PIK3CD [activation] CD247 GRB2 [activation] PLK1 PITPNM1 [activation] CDKN1A CDC42 [activation;inhibition] GRB2 C1orf94 [activation] PTPN14 CTNNB1 [activation] JAG2 NOTCH3 [activation] GABPB1 FHL2 [activation] ARHGDIA FASLG [activation] APC POM121 [inhibition] KIT ZAP70 [activation] SRPK2 FOXN3 [activation] TLR2 TLR10 [activation] CBL TGFBR2 [inhibition] GRIP1 EHMT2 [activation] LAMTOR5 GIT2 [activation] PRKCD PLD2 [activation] NIT1 ZFYVE9 [activation] GADD45A GADD45B [activation] SRC ARHGAP17 [activation] RAD21 ITGAM [activation] TGFA GORASP2 [activation] MED1 GATA1 [activation] TET2 OGT [activation] CREB1 GTF2A1 [activation] SUMO1 HSPB1 [activation] MYL12A SUV39H2 [activation] NPM1 ACACA [activation;inhibition] PSMD11 INSIG2 [activation] MDM2 HMHA1 [activation] RALGDS CD68 [activation] ITSN2 PSEN1 [activation] ASB6 FGA [activation] CCDC120 CCDC57 [activation] SRF MAPKAPK2 [activation] BCL6 ARNT2 [activation] RRAS RASSF5 [activation] SMYD2 SNRPB2 [activation] MAPK14 IQGAP1 [activation] GCN1L1 PTP4A3 [activation] BID BCL2L11 [activation] MIF HSP90AA1 [activation] SBF1 TNFSF11 [activation] MAST1 PAXIP1 [activation] CD3E EPS8L1 [activation] PIK3CA IL24 [activation] CDH18 CDH9 [activation] PRKAA1 GOLGA2 [inhibition] EIF1AX EIF6 [activation] PRKD2 PFDN1 [activation] MSRB2 RAD21 [activation] CDK5RAP1 CDK5R1 [activation] GRB2 MYO1A [activation] CDH12 IGHG1 [activation] BCAR1 RAN [activation] TSHR SCRIB [activation] RAN XPO1 [activation] GNAQ RIC8B [activation] FKBP11 RELA [activation] WNT4 APP [activation] NXF1 MTHFSD [activation] TRAF3 LTBR [activation] SERBP1 CD81 [activation] RPA3 TFE3 [activation] STAU1 DDX39B [activation] MYC WDFY3 [activation] FHL2 MAPK1 [activation] 页 403 共 454


2016/4/8 19:15

PRKDC EP300 [activation] NCOA1 PAGR1 [activation] RPL11 CD81 [activation] C12orf60 BMP4 [activation] MAPK6 METTL17 [activation] DOCK8 LRCH2 [activation] MAPK8 NFE2 [activation] BIRC2 EGFR [activation] SFN RACGAP1 [activation] SRC YTHDC1 [activation] COL4A5 OSM [activation] NLRC4 NLRP3 [inhibition] NOTCH3 CSNK2B [activation] APOE SCARB1 [activation] HYOU1 GABARAPL2 [activation] CCND1 HSPA8 [inhibition] SOX10 HHEX [activation] WASF1 RAC1 [activation] HIST1H3A ITGA4 [activation] CCDC124 EIF2AK2 [activation] DUSP19 MAP3K5 [inhibition] ACTR3 EIF1B [activation] IGF1R VAV3 [activation] BMPR2 PPP1CC [activation] CD164 ACKR3 [activation] IL16 CDK1 [activation] RELA NCL [activation] NOTCH3 ANKRD28 [activation] SOCS3 ABL1 [activation;inhibition] ARF4 SDCBP2 [activation] SP3 ESR1 [activation] GNAI1 S1PR1 [activation] SMURF1 ARHGAP5 [inhibition] CAMK1D CDC25A [activation] XAGE1A PAXIP1 [activation] CDC42 ACTR3 [activation] CELSR2 SRC [activation] P2RY1 SLC9A3R2 [activation] MYOD1 SRF [activation] PRKACA MBP [activation] SOS1 CD19 [activation] ENAH PFN1 [activation] VCAM1 PRRC2C [activation] PIK3R1 DAB2 [activation] MST1 STK11 [activation] PIAS4 HIF1A [inhibition] CARD11 AKT1 [activation] UBASH3B EGFR [activation] HSPA8 PPP1R12B [inhibition] EMP3 CREM [inhibition] APP YWHAZ [activation] TNF RPS18 [activation] RPS6KB1 SYK [activation] APBB1 EVL [activation] ANXA7 SETDB1 [activation] STAT6 IFNG [inhibition] SMAD3 NR3C1 [activation] C19orf44 SPERT [inhibition] BCL10 MAP2K7 [activation] FFAR1 GNAI1 [activation] ABCA1 ARHGEF11 [activation] ACTG1 SUMO4 [activation] F8 LRP1 [activation] TRAF2 CCNJL [activation] HSF1 SUMO3 [activation] IKBIP MYOG [activation] RAD21 MCM4 [activation] DBP EP300 [activation] DDX58 TRIM25 [inhibition] SMURF1 RNF141 [inhibition] OTX1 LCE2A [activation] ACVR1 RASL12 [activation;inhibition] XPO1 ERBB2 [activation] MRPL23 SPP1 [activation] LATS1 RAC1 [activation] PTK2 BMX [activation] 页 404 共 454


2016/4/8 19:15

YY1 RB1 [activation] TRAF6 PIN1 [activation] AVPR1A VIP [activation] UBE2I SETD8 [activation] MYC H3F3A [activation] ROR2 HSP90AB1 [activation] SMARCAL1 RPA2 [activation] DLL1 MAGI2 [activation] PML PAXIP1 [activation] MTOR MAPKAP1 [activation] IL2RB ECM1 [inhibition] PRKCI ARHGAP17 [activation] EGFR MCM3 [activation] SHC1 AR [activation] SFN MPRIP [activation] SORCS3 NGF [activation] PPARG RAD54L2 [activation] MAP4K4 HSP90AA1 [activation] BHLHE40 EZH2 [activation] RELA MAFK [activation] PAK1 SMAD4 [activation] ESR1 HDAC4 [activation] CAMK2B MVP [activation] AKT2 SORBS2 [inhibition] FHL2 PTCH1 [activation] EPHA3 SRPK1 [activation] CRTC2 ATF6 [activation] IRF7 TICAM2 [activation] FOS CEBPE [activation] RCN1 MYC [activation] TRAF6 MAP3K5 [activation] CTSD INS [activation] CTNNB1 TAX1BP3 [activation] RET CASP3 [activation] PLEKHO2 APP [activation] RAC1 OPHN1 [activation] ADRB2 EIF4A1 [activation] ETV4 EP300 [activation] RAB3GAP2 VAPB [activation] STAU1 ARF6 [activation] ITGA4 ENO1 [activation] DDAH2 TNFSF11 [activation] PLCG2 PTPN11 [activation] RANGAP1 NXF1 [activation] RPA3 RAD50 [activation] HSPB3 LSM14B [activation] S100A1 PLN [inhibition] TLR3 IRAK2 [activation] CNKSR2 RAF1 [activation] YWHAQ TSC2 [inhibition] HMGB1 GTF2A1 [activation] AURKB PUM1 [activation] TPT1 MDM2 [activation] YWHAB SIPA1L3 [activation] MECR RARA [activation] PRKAA1 CAMKK1 [activation] TIMP1 RECQL5 [activation] ADAMTS13 F8 [activation] SDF4 APP [activation] RHEB PLD1 [activation] TRIM28 VCAM1 [activation] MYO1C E2F3 [activation] HNF4G NCOA1 [activation] RASSF1 CUL1 [inhibition] RALA RASSF5 [activation] CEP250 F7 [activation] TP53 LYZ [activation] ITK PLCG2 [activation] EP300 FBXL5 [activation] CCDC102B FAM127C [activation] HIST2H3A MSL2 [activation] DDX58 PRKCA [activation] PAXIP1 NCAPD2 [activation] ITGB4 MET [activation] BTRC SNAI1 [activation] EGFR NSUN5 [activation] 页 405 共 454


2016/4/8 19:15

LCK SH3BP2 [activation] AGTR2 GNAI3 [activation] SIRT3 CMYA5 [activation] CDK11A CDKN2A [activation;inhibition] SHC3 RET [activation] UBE2H CD99 [activation] EIF4A3 CAPZB [activation] HIST2H2BF YWHAZ [activation] PXN ITGA6 [activation] PRKCA TRPC3 [activation] CNTN2 L1CAM [activation] PYCARD NLRP12 [inhibition] MDM2 PDCD5 [activation] MSTN WFIKKN1 [activation] CD2 CD53 [activation] ATAD3A TP53 [activation] DUSP16 MAPK1 [inhibition] RELA CCAR2 [inhibition] MAPK14 ATM [activation] TRAF2 TMC8 [activation] ZBTB17 CREBBP [activation] SPERT C14orf105 [inhibition] PTPN13 BRD7 [activation] NRXN2 MLLT4 [activation] OGDH ESR2 [activation] MAPK3 FCGR2B [activation] MAPT MARK3 [activation] FASTKD5 FBXO6 [inhibition] GABARAP TSR2 [activation] JUN SMAD2 [activation] GRB7 KCTD6 [activation] TRRAP TP53 [activation] EIF2S1 CSNK2A1 [activation] LTA CLSPN [activation] XPOT RAN [activation] NIF3L1 EPHB6 [activation] FYN SPHK1 [activation] MMP14 MMP2 [activation] ARMC6 STK36 [activation] STAT3 BHLHE40 [activation] RFC4 NOTCH1 [activation] CLSPN CASP7 [activation] ESR1 BCL3 [activation] C22orf46 SMAD2 [activation] PIK3C3 EXOC8 [activation] SMARCA4 SRF [activation] TLR2 TGFB1 [activation] LYN RGS16 [activation;inhibition] ULK2 POLA2 [activation] CASP3 TRAF3 [activation] PF4 IL8 [activation] FOXP3 PRR20C [activation] GRB2 DDX5 [activation] GIT1 PAK3 [activation] HSPA8 SUMO3 [inhibition] ETS1 PCNX [activation] TOP2A PRKCB [activation] ULK1 GABARAP [inhibition] SSH2 CFL1 [activation] SUV39H2 KLHDC4 [activation] COL1A1 CAPN1 [activation] PEG10 ACVR2B [activation] MST4 SRPK1 [activation] RASSF1 C8orf33 [inhibition] SUV39H1 CTNNB1 [activation] CASP6 IKBKG [activation] RELA PIAS1 [inhibition] PDE3B PIK3R6 [activation] CACNA1C PPM1A [activation] FYN SPN [activation] ARHGDIB UFM1 [activation] EGFR JAK2 [activation] SLC25A6 TNFRSF10C [activation] KCNQ1 CALM1 [activation] KPNA1 NFKB1 [activation] CTTN PTPN1 [activation] 页 406 共 454


STAT3 IL7R VAPA HLA-B PLCG1 PKN2 CCL3 CEBPB FLNB PLCG1 XPO1 FADD PBX1 TLX1 ERC1 IKBKB SIRT1 KCNAB2 TRAF6 UBE2E1 SFPQ RAC1 TP53 NME4 FAM65B WNK1 CCND1 RB1 TP53 RPL12 CFLAR RAF1 FANCM MYC SF3B14 ITGA4 DDX39B SHFM1 TUBB3 GRB2 PHGDH GRB2 PPP2CA NKD1 AKT2 SH3RF1 CACNA1A ALDOA DNAJB5 CACNA1A CSNK1A1 CHRM3 PHF5A VCAM1 RACGAP1 PLK1 CHD4 RPA1 MRFAP1L1 UBE2R2 ARHGDIA APC MAPRE2 ITGA4 PRDX2 ARRB2 CDK4 STX3 NAPB SH2B3 GRB2 GRB2 SLX1A CNPY4 ARL4D NRAS SMAD4 IL3RA PLCG1 GADD45G LUC7L2 BMP3 WFIKKN1 DYNC2LI1 CXCR4 SOCS1 HOXC6 CHEK2 DYRK1A YWHAB CHD1L PRKDC KAT2B CREBBP CCL8 VCAN MAP3K3 GNAI3 CREBRF CREB3 BCL2L1 BAG1 SERPINA10 VAV2 ABI1 TFRC ITGA4 TRAF2 KIFC3 MDM2 POT1 TP53 PIN1 RHEBL1 ACVR1 CDKN2D NR4A1 FAM13C DVL3 SIX1 TLE1 TPT1 HLA-B RPA1 PRIMPOL PLD1 ACTB PRKDC HMGB1 ATG16L1 CASP3 EVL WAS RPA3 CAV1 ANXA1 VCAM1 PIK3CA WDR5 RNF4 NFE2L2 NR3C1 STAT5B PRKCE IL32 RPA1 MCM6 MAP2K1 PSMD10

2016/4/8 19:15

[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [inhibition] [inhibition] [activation] [activation] [activation] [activation] C3orf62 [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] SOD1 [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] F10 [inhibition] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] 页 407 共 454


2016/4/8 19:15

NR3C1 KDM5A [activation] HSP90AB1 CAMK1G [activation] TRAF6 TUBB [activation] PTPN6 PILRA [activation;inhibition] ARHGEF7 CBLB [activation] ARF1 PICK1 [activation] YWHAG RAPGEF6 [activation] SIRT1 TP73 [activation;inhibition] IGHA1 APOC1 [inhibition] PFN2 EVL [activation] TUFM OBSL1 [activation;inhibition] STK38 MOB1A [activation] TGFA RHBDF1 [activation] RASA1 CSK [activation] MAFK MARS [activation] ACTN1 VCL [activation] GRB2 AP4S1 [activation] KCTD12 RELA [activation] SGTA CDH15 [activation] MAGED4 PHYHIP [activation] F13A1 SH3GL2 [activation] CSNK1G2 SMAD3 [inhibition] MBP MAPKAPK5 [activation] RET SHC1 [activation] ITGB2 CD14 [activation] TRAF6 PAFAH1B2 [activation] ADA ADORA2A [activation] KIT BLK [activation] AKT1 PLCG1 [activation] TNIK PPP2R1A [activation] PELI3 MAP3K7 [activation] CHD8 SUMO3 [inhibition] FCAR FCGR1A [activation] PPARG CHD7 [activation] INPPL1 EFNA1 [activation] SDF4 SNCA [activation] RAC1 PPP2R4 [activation] ACP6 ILK [activation] NSD1 ATRX [activation] EP300 DNA2 [activation] SUFU SETDB1 [activation] RGS19 TGFBR1 [activation;inhibition] SRPK2 KCNN2 [activation] MDC1 SUPT6H [activation] MAG COL9A2 [activation] SH2B1 IGF1R [activation] HDAC4 NFATC1 [activation] TBL3 SFN [activation] MPL YWHAQ [inhibition] SNCA PLD1 [activation] ZRANB1 PGAM5 [activation] CD3E NCL [activation] BRPF3 GRB2 [activation] FGFR2 FYN [activation] ADAMTS12 A2M [inhibition] BCL2L11 TRIM2 [activation] DCN INS [activation] EYA3 SIX4 [activation] TP53 HDAC2 [activation] GADD45G CRIP2 [activation] CASP7 MEF2A [activation] MCM2 CCL2 [activation] DIABLO ELAVL1 [activation] C1orf174 SRPK2 [activation] PIK3R3 DARS [activation] GH1 CAPZB [activation] SNRNP70 ITGA4 [activation] PIAS1 CEBPA [inhibition] HRAS TLR2 [activation] NR3C1 MAFF [activation] PRSS23 NCAPD3 [activation] TNFRSF25 TRAF2 [activation] RELA NFKBIE [activation] MYH11 SHC1 [activation] GABARAPL2 IRGQ [activation] LYN TMX1 [activation] 页 408 共 454


2016/4/8 19:15

SRPK1 SRPK3 [activation] TP53 PRKCA [activation] CREM CREBBP [activation] ROCK1 NCL [activation] CUL1 PTGS2 [activation] HNRNPA1 RPA2 [activation] TRIM16 E2F1 [activation] CTNNB1 CASP8 [activation] PPP1CC CCDC85C [inhibition] SUMO4 FOS [activation] ZAP70 RASA1 [activation] MCL1 CAV1 [activation] CSNK2A2 MYF5 [activation] PIK3CD TNPO2 [activation] MDM2 RAD50 [activation] MSH4 GPS2 [inhibition] VTI1B STX5 [activation] EED RAC1 [activation] CCND1 BTRC [inhibition] ANXA7 CPNE2 [activation] YWHAG TSC2 [activation] IRF3 CUL1 [inhibition] RAD21 PHACTR4 [activation] DCN TNF [activation] CDH1 PTPRF [inhibition] HLA-B PA2G4 [activation] FGR VDR [activation] HLA-B IGF2BP1 [activation] HIST1H2BL GABARAPL2 [activation] RHOA TGM2 [activation] C3 VHL [inhibition] PML TERT [activation] GDF9 CDKN1A [activation] RHOA ARHGAP8 [activation] PTK2 TNFRSF1A [activation] PTK2B GNA13 [activation] CDC5L EIF2B4 [activation] YWHAH PYHIN1 [activation] PLCB1 RGS12 [activation;inhibition] RARA NFE2L2 [activation] ZAP70 GRB2 [activation] THBS1 HRG [activation] ITGB1 GULP1 [activation] CDK1 LYN [activation] MBP PRKCI [activation] FBXO6 SMC2 [activation] ACTG1 ADRB2 [activation] SMAD5 HMGA2 [activation] KLHL42 FAM168A [activation] APOC3 ARFGAP1 [inhibition] SHC1 CD22 [activation] ACACA ARRB1 [activation;inhibition] MAP3K10 RAC1 [activation] INSR PIK3R3 [activation] MAP3K7 MAP3K5 [activation] VDAC1 CD4 [inhibition] PIK3CA AMBP [activation] MDM2 USP42 [activation] CDH6 CDH10 [activation] P4HB MAPT [activation] NBN MDC1 [activation] CEP44 CDC23 [activation] PECAM1 HCK [activation] PPP2R1A CHEK2 [activation] TP53 SP1 [activation] HSP90AA1 KDR [activation] PAX6 RGS3 [activation] RAB11B RPA1 [activation] PTPN6 SLAMF6 [activation;inhibition] ZNF420 TP53 [activation] HEMGN AXIN2 [activation] STK11 C9orf156 [activation] CDH5 CTNNA1 [activation] ULK2 DIXDC1 [activation] KCNH5 KCNH1 [activation] NOTCH1 LRBA [activation] 页 409 共 454


2016/4/8 19:15

ARMC7 C2orf88 [activation] ANG MDM2 [activation] PPP3R2 CD14 [activation] DNAJC28 MAPK6 [activation;inhibition] RPS6KA6 RXRA [inhibition] IGF2BP3 MDM2 [activation] RXRA NR1I2 [inhibition] PCDH18 DAB1 [activation] MYF6 TCF3 [activation] YY1 SMAD3 [activation] SORCS2 NTF3 [activation] IKBKE ACTG1 [activation] SOX2 ANAPC5 [activation] USP9X SHC1 [activation] BLVRA MAPK1 [activation] MIF UBC [activation] HSPA1L CFTR [inhibition] RAG2 KPNA1 [activation] MARK3 MAP2 [activation] ARRB2 HSPA1L [inhibition] DPYSL2 DPYSL5 [activation] CD4 HSP90AA1 [activation] SIX1 VTN [activation] FBXW11 IFNAR1 [inhibition] PLAT LAMA5 [activation;inhibition] PARD3 CSK [activation] FGFR1 MMP2 [activation] CDK2 GSTK1 [activation] VCAM1 DIMT1 [activation] CYLD SPATA2L [inhibition] COL4A5 MMP9 [activation;inhibition] MAPK1 ALK [activation] PSEN1 BCL2 [inhibition] PRNP MAPT [activation] CCND1 CARD11 [activation] GRB2 BRCA2 [activation] ARHGEF7 ITCH [activation] MAPT CDK1 [activation] SNX33 WAS [activation] NDRG1 PRKACA [activation] GRB2 CORO1C [activation] RPS6KA1 NR4A2 [activation] CDC14A TP53 [activation] TGFBR2 TCTEX1D4 [activation] UBXN7 BRWD3 [activation] PRLR VAV2 [inhibition] APP RPS6KA6 [activation] RASAL2 CSNK1E [activation] MOCS2 STK11 [activation] NCOA3 ESRRA [activation] LAT GRAP2 [activation] TBL3 WHSC1 [activation] LCP2 SH3GL2 [activation] CRK LIG3 [activation] RPS6KA3 NR4A1 [activation] RRAS NCK1 [activation] RPTOR LAMTOR4 [activation;inhibition] COPS6 CASP6 [activation] DNM2 ERBB2 [activation] HIST1H3A SFMBT1 [activation] HSPB1 PELO [activation] YWHAZ CALM1 [activation] NTRK1 PTPN11 [activation] MYL12A CDC42BPA [activation] PRKCB KCNA5 [activation] JUNB PKIA [activation] HNRNPA1 GTF2A1 [activation] TP53 PAGR1 [activation] HSPA8 CBL [inhibition] PRIMPOL RPA2 [activation] MDM2 ALDH16A1 [activation] LIMK1 HUNK [activation;inhibition] MAST2 SLC9A3 [activation] EPOR GAB2 [activation] F10 SERPINA5 [inhibition] LAMTOR4 LAMTOR5 [activation] 页 410 共 454


2016/4/8 19:15

USHBP1 GPSM1 [inhibition] STAT3 STAT1 [activation] CFTR HSPA6 [activation] DCC BARD1 [activation] GFAP MOS [inhibition] CALM1 PTPRA [activation] RCC1 TP53 [activation] HTRA2 MAPK14 [activation] LIMS1 RSU1 [activation] JUN VAV1 [activation] F2 C1QBP [activation] NFYB HDAC1 [activation] PTPRT STAT3 [activation] ICAM1 ALYREF [activation] TRIM50 UBE2N [activation] CCL20 TRAF6 [activation] ARF1 ARFIP1 [activation] TGM2 GRN [activation] RAB13 TGFBR1 [activation] GABRD NOTCH2NL [activation] RALA PIH1D2 [activation] CTTN ARPC3 [activation] PTPN22 ZAP70 [activation] FLT4 PTPN11 [activation] DUSP4 APP [inhibition] CCNA1 SRC [activation] MARK3 PPM1B [activation] TRAF1 TP53 [activation] ADAP2 PRNP [activation] MDM2 MYD88 [activation;inhibition] CDC7 DBF4 [activation] BIRC5 HIST2H3A [activation] TAF1B TAF1A [activation] PPP1CA GPR12 [activation] DBF4 CHEK2 [activation] FCRL3 ZAP70 [activation] WASF1 ACTG1 [activation] HSP90AA1 WNK4 [activation] HLA-C HLA-B [activation] BMPR1B DCAF6 [activation;inhibition] HNRNPA1 AURKA [activation] LRRK2 DNAJA1 [activation] SUMO3 JUP [inhibition] SOX9 KPNB1 [activation] PRRC2C AURKA [activation] TIMELESS PRIMPOL [activation] SNIP1 CDK6 [inhibition] RIPK2 CALM1 [activation] PIK3CG ZNF282 [activation] PPP1CA CCNA1 [activation;inhibition] E2F1 MCPH1 [activation] MAPK1 HLA-B [activation] RASA1 GRB2 [activation] WASF2 YWHAQ [activation] STAB2 MAPK1 [activation] MAX EP400 [activation] PIK3CA FTL [activation] POLR2L CHEK2 [activation] FAM213A APP [activation] TAGLN2 MAPK13 [activation] SMURF1 AVEN [inhibition] STK4 HSPA5 [activation] IKBKE RAB21 [inhibition] TPD52L3 AGTRAP [activation] CAMK2G MCM7 [activation] PCBP1 MAP4K3 [activation] BCL2 BAD [inhibition] PRKCQ AKT1 [activation] GABARAPL1 NUP214 [activation] UBE2E2 MID1 [activation] TP53 XPC [activation] INSC GPSM2 [inhibition] SMAD2 RAB34 [activation] PIN1 LEPR [activation] SMARCA4 SMAD3 [activation] GRIA4 PRKCA [activation] 页 411 共 454


2016/4/8 19:15

TRAF6 ITCH [activation] ATM ATF2 [activation] CASP6 NEDD4 [inhibition] ANXA1 TGM2 [activation] PTPN6 FAS [inhibition] ATF3 FHL2 [activation] PPP1CC TP53 [activation] ADRA1B IGHG1 [activation] TIAL1 RPA3 [activation] PRDX5 MDM2 [activation] STMN1 CDKN1B [activation] EIF1B HYPK [inhibition] FANCI HELQ [activation] NF1 CDC5L [activation] ACTB PHACTR4 [activation] HIST3H3 HNRNPA1 [activation] NEURL4 DBNL [inhibition] PRKAA1 CTBP1 [inhibition] ATM CXXC5 [activation] FCGR3A PTPRC [activation] UBE2E3 RNF114 [activation] NUDT5 HLA-B [activation] SMAD5 PNKP [activation;inhibition] TNFSF13 PIK3CA [activation] ERBB4 MDM2 [activation] YWHAZ ACTG1 [activation] GADD45G AFAP1L1 [activation] ENG TCTEX1D4 [inhibition] NR4A1 ROBO2 [activation] RUNX1 KMT2A [activation] MAD2L2 POLD3 [activation] LIPC ADHFE1 [activation] EIF2S1 CASP3 [activation] GNAO1 HTT [activation] NUDCD2 RTN4RL2 [inhibition] PIP5K1A PIP5KL1 [activation] PPM1B GSN [activation] HMGB1 MNT [inhibition] FRK CSK [activation] SLC30A2 CCL4 [activation] PPP2R2B CDC42 [activation] BIRC2 TRADD [activation] ATP6V0B YWHAG [inhibition] ITGB2 CYTH2 [activation] ACKR4 CCL21 [activation] MMP2 THBS2 [activation] GRB2 MAPK12 [activation] PRKAA1 THAP1 [inhibition] NTRK1 HSP90AB1 [activation] CSNK1G2 C2orf44 [inhibition] NTM NEGR1 [inhibition] ENO1 ATF2 [activation] SPG20 ZFYVE9 [activation] MMP1 CCL13 [activation] FOXH1 GRB2 [inhibition] DDX21 SRPK3 [activation] EZR CTNNB1 [activation] HLA-B KIR3DL1 [activation] GLI3 SMAD4 [activation] GAB1 PTPRG [activation] SCTR CALM1 [activation] RPS6 GABARAP [activation] ITGB1BP1 LRP1 [activation] SUMO1 MEF2A [activation] LTK SHC1 [activation] FANCD2 CEBPD [activation] LIN7B ASIC3 [activation] AMOT MAPK3 [activation] PIK3CG PIK3R5 [activation] EGFR EPN1 [activation] STX7 STX6 [activation] ARRB2 GSN [activation] GAP43 PRKCD [activation] RAD21 STX10 [activation] PALB2 DIRAS3 [activation] EGFR WASL [activation] 页 412 共 454


2016/4/8 19:15

EP300 STAT2 [activation] DRP2 DAG1 [activation] SP1 DDX5 [activation] GNB5 RGS6 [activation;inhibition] CD2 CD2BP2 [activation] CMSS1 EGFR [activation] FOXM1 CCNE1 [activation] YME1L1 MYOG [activation] TP53 ERCC6 [activation] GRB2 ITGA6 [activation] SP1 JUN [activation] NUDCD3 KLHL32 [activation] HIST3H3 TAF1B [activation] PPARA PRMT2 [inhibition] SRPK2 C17orf85 [activation] AP2M1 ACACA [activation;inhibition] IL1B FYN [activation] PLEC RAPGEF2 [activation] MRFAP1L1 PIH1D2 [activation] PPM1B RASGRP1 [inhibition] PIK3R1 GAB3 [activation] SHCBP1 SFN [activation] ITCH DVL1 [activation] PIAS1 SMAD4 [inhibition] MAP4K2 MAP2K4 [activation] YWHAE KCNK15 [activation] CDC5L DDX39B [activation] STK11 APP [activation] INADL ARHGAP17 [activation] EGFR FANCC [activation] MMP13 F12 [activation] ARF1 ITGA4 [activation] TP53 SMAD1 [activation] NUDC KLHL6 [activation] BTC MMP9 [activation] CDC42 ARHGAP29 [activation] MYC ROBO2 [activation] RXRA HDAC4 [inhibition] TGFB1 THBS1 [activation] GRB2 MTA3 [activation] NRAS RACGAP1 [activation] EGFR NELL1 [activation] EDNRA EDN1 [activation] ADAM17 SH3D19 [activation] DLX6 HSP90AA1 [activation] DAB1 PRR20E [activation] TSPAN5 ADAM10 [activation] AGAP1 GUCY1A3 [activation] SERPINB4 BTRC [inhibition] CREBBP SPI1 [activation] DVL2 TP53 [activation] UBE2J2 XIAP [inhibition] PPP3CA TP53 [activation] TFCP2 PIK3CB [activation] ARRB2 MAP2K1 [activation] UBTF ESR1 [activation] ABL2 KIT [activation] PLK1 IKBKB [activation] TNFRSF1A JAK2 [activation] CDC27 AURKB [activation] CCNE1 NFYB [activation] YWHAZ PARD6A [activation] NOTCH2NL CCDC93 [activation] CCDC8 GNAI2 [activation;inhibition] ADAM17 PXN [activation] BCL2L2 BID [activation] SRPK1 C15orf39 [activation] SMURF1 PAK1IP1 [inhibition] UBE2W XIAP [activation] MDM2 SNAI2 [activation] UHMK1 STMN1 [activation] MYC KIAA2026 [activation] VAV1 EGFR [activation] VEPH1 TGFBR1 [activation] MAPK1 NR4A1 [inhibition] SLX4IP PLK1 [activation] 页 413 共 454


2016/4/8 19:15

SRSF10 YWHAQ [activation] TRAF2 JUN [activation] YWHAG ARHGEF6 [activation] SRC RGS16 [activation;inhibition] TGFBR1 NAT8 [activation] INADL SAV1 [activation] ILK MARS [activation] HEATR2 CASP4 [activation] RPL22L1 RAD21 [activation] ATF5 GIT2 [activation] TGFBR1 GNA13 [activation] UBC IL18 [activation] ELK4 FOS [activation] SP1 SMAD3 [activation] PRKAA2 MLF2 [activation] METTL21C MAD1L1 [activation] PLD1 PLCG1 [activation] YAP1 RUNX1 [activation] PVRL4 PVRL1 [activation] PPP1CA TSC2 [activation;inhibition] MAP3K14 CFLAR [inhibition] STAT2 STAT3 [activation] SMAD4 RASL12 [activation] NFKB1 C1orf52 [activation] FANCA CTNNB1 [activation] NUDC FBXO24 [activation] TIMELESS CHEK1 [activation;inhibition] MAPT PPP2R4 [activation] CTNND1 KCTD6 [activation] EIF2AK2 NOC3L [activation] MEIS2 ARNT2 [activation] CDC14B TP53 [activation] SGOL2 PPM1A [activation] PLG SERPINE1 [inhibition] DDIT3 TRIB3 [inhibition] STK11 NAT2 [activation] FBXW5 NLK [inhibition] ARFGAP1 ASB10 [activation] APP PFKFB1 [activation] NR5A2 SRC [activation] COG4 APC [inhibition] G3BP2 RPL22L1 [activation] CNKSR1 RHOC [activation] SIRT1 SETD7 [activation] RICTOR EHMT2 [activation] ONECUT1 KAT2B [activation] FBXO6 SMCHD1 [inhibition] UBASH3B CRK [activation] AKT2 APOB [activation] ASB7 ATF4 [activation] SHANK3 GRB2 [activation] RELN VLDLR [inhibition] CSNK1E TAOK1 [activation;inhibition] KMT2A PAX5 [activation] LDLR PF4 [activation] RASGRP3 PIK3CA [activation] ANAPC15 CDC26 [activation] IL17RB DAZAP2 [activation] GNAQ MRGPRX1 [activation] GNAI2 ADRA2A [activation] ZFYVE21 NOTCH2NL [activation] FGF2 RPS6KA3 [activation] TNK2 GRB2 [activation] RPA3 RAB8A [activation] IRF3 RBL1 [inhibition] JAK1 IGF1R [activation] RELA TERT [activation] SPHK2 LYN [activation] RAB43 APP [activation] CDC7 GPT [activation] PSEN2 RNF32 [activation] CEBPD CEBPG [activation] LGR4 TFRC [activation] FZD4 NDP [activation] ZFYVE9 RHO [activation] PEBP1 SMYD2 [inhibition] 页 414 共 454


2016/4/8 19:15

PTPN11 DDR1 [activation] WWC3 CDK5RAP3 [activation] EIF1B EIF2S3 [activation] EEF2K MAPKAPK2 [activation] HSP90AB1 MAP3K15 [activation] CDC23 CCDC24 [activation] SRF MYOG [activation] CHRNA4 CHRNB4 [activation] ALG2 PTK2B [activation] MAG RTN4R [activation] MAPK8 CBL [activation] USP12 MMP2 [inhibition] NCAN L1CAM [activation] TBXA2R GPRASP1 [inhibition] JUP ESR1 [activation] HLA-C LILRB1 [activation] FOXP4 FOXP1 [activation;inhibition] SIRT2 KAT2A [activation] LYRM4 PVRL2 [activation] TP53 NOTCH4 [activation] WDR5B ESR1 [activation] ATF2 SFXN1 [activation] PIK3R3 QARS [activation] RAD17 CDH1 [activation] WHSC1 BAZ1B [activation] IRF2 ATG7 [activation] CTSK KNG1 [activation] MMP1 MMP7 [activation] GREB1 TGFB1 [activation] SPOCK3 MMP3 [activation] G6B ABL2 [activation] PPP1CC BCL2 [inhibition] E2F3 SHOC2 [activation] FTL MYOG [activation] HSPB1 LIG1 [activation] DNM1L VIM [activation] MAPK9 RB1 [activation] YWHAZ TFRC [activation] PDCD11 MYC [activation] USF2 NFYA [activation] GREB1 CASP8 [activation] MAP2K7 SNW1 [activation] PPP1R21 PPP1CA [activation;inhibition] TRAF3 TNFRSF8 [activation] FYN MAG [activation] GARS MAPK8 [activation] VTN HGF [inhibition] TBC1D17 CDKN2D [inhibition] FOXO3 USP7 [inhibition] MDH1 EGFR [activation] VCAM1 PCBP1 [activation] CCAR2 MYC [inhibition] PTPRC TYK2 [activation] LPL PTPN4 [activation] PRKCZ MARCKS [activation] RPL38 DCC [activation] GABARAPL2 C18orf32 [activation] YWHAB ABL1 [activation] SPERT CCDC146 [inhibition] CLPP HLA-B [activation] GATA1 TRIM29 [activation] CDK1 IL3RA [activation] PARD3B SFN [activation] ZRANB1 MAP4K4 [activation] COMMD2 NFKB1 [activation] PRKG1 TBXA2R [inhibition] HMGB2 POU5F1 [activation] ARPC4 MOV10 [activation] MRPL53 APP [activation] ARMC8 CTNNB1 [activation] CDC37 SGK1 [activation] LCK WAS [activation] KCNJ1 PRKCD [activation] LRCH3 LRCH2 [activation] NBN HSPA4 [activation] GPRASP1 CHRM5 [activation] 页 415 共 454


2016/4/8 19:15

FOXO1 GSK3B [activation] TOP3B CHD8 [activation] MAPK3 RXRA [inhibition] MCM6 IL36RN [activation] TLE1 BCL2L1 [activation] GNAI3 C5AR1 [activation] VDR NRIP1 [activation] MDM2 SFXN3 [activation] ID4 CRK [activation] PAK1 ARHGEF2 [activation] GINS2 CHEK2 [activation] MAP3K19 ZDHHC17 [activation] TAB1 HSPA8 [inhibition] NAA15 HLA-B [activation] CASK WNT7B [activation] HMGXB4 NR1H2 [activation] SIKE1 MST4 [activation] MAPKAP1 MYC [activation] TRIM49 HSP90AB1 [activation] STK4 CDC37 [activation] GNA13 MCF2 [activation] MOV10 ANAPC1 [activation] PDGFRB PTPN22 [activation] SUMO1 DYRK1A [activation] PNPLA3 AKT2 [activation] AR SLC25A4 [inhibition] CCDC158 C1orf216 [activation] SDCBP2 NRXN1 [activation;inhibition] CAPNS1 TRAF5 [activation] CARM1 STAT5A [activation] NTRK3 MAPK3 [activation] CDC37 ALS2 [activation] SMURF1 TRIB3 [inhibition] SH2B2 AKT1 [activation] MAP3K5 RAF1 [activation] KNG1 CAPN1 [activation] CEBPE PIAS1 [inhibition] MAPK14 TOLLIP [activation] ADRB2 GRK6 [activation] STAT1 PTK2 [activation] TP53 ERBB4 [activation] CDX4 CKS1B [inhibition] SGK1 MAGEA1 [activation] PRKCD MBP [activation] TBC1D4 CDKN1A [activation;inhibition] NXF1 TATDN2 [activation] MDM2 IRF2 [activation] RBL1 NR4A1 [inhibition] CEP55 CCBE1 [activation] WAS PACSIN1 [activation] CSN1S1 STK4 [activation] EHMT2 ESCO1 [activation] NFYA CCNA2 [activation] YWHAH AKT1S1 [activation;inhibition] HLA-A HLA-C [activation] ABL1 AR [activation] SHC1 PPP2R5A [activation] TNFRSF11A MAP3K7 [activation] F2RL1 TMED10 [activation] STAB2 TMSB4X [activation] GABBR2 KCTD12 [activation] CTBP1 CTNNB1 [activation] SERPINB6 F2 [inhibition] ARRB2 HSPA6 [inhibition] EGFR LRRC40 [activation] GNAS AXIN1 [activation] TRAF6 EPPK1 [activation] MAPK6 MYBL2 [inhibition] KCNB2 GRB2 [activation] ARMC8 EGFR [activation] FANCD2 CDC5L [activation] EGFR ACTR2 [activation] STAT5B EP300 [activation] BMPR1B RRAS2 [activation] ADRB2 TMX1 [activation] ACVR1 ACVR2A [activation] 页 416 共 454


SRPK1 RPA2 CDK18 BMPR1A CAV1 TGM2 SYNJ2BP CRH TERF1 VIM CDKN2C HDAC1 CARM1 CRKL TP53 ATF3 RANBP2 SMAD3 KMT2D YWHAE CFHR4 SMAD2 SIVA1 NRAS RPL17 CDC16 RBBP6 IL5RA FGR NR1H2 SGK1 KNG1 ESR2 PIAS1 SMAD1 LAMA5 SOX9 GNA13 RASSF1 SMAD4 KPNA4 APC FYN H2AFX TSSK3 GEM SDC4 RGS19 CDKN1A SLA SIRT1 CACNB4 PTK2B TRDN BTK SNAP29 ANXA7 CDAN1 CAV1 YWHAH TRAF6 CDK6 RBPJ RRBP1 ARPC4 SRSF10 CCDC146 PPARG SLA HLA-B PRKACA APC SELPLG CAMK2D NBN SRPK2

2016/4/8 19:15

FGF12 [activation] TFRC [activation] YWHAH [activation] HSP90AB1 [activation] RCVRN [activation] ACTB [activation] ACVR2B [activation] CRHR2 [activation] GIT1 [activation] LRRK2 [activation] UNC119 [inhibition] MEF2A [activation] NRIP1 [activation] VCAM1 [activation] HSPB1 [activation] JUNB [activation] NUP153 [activation] PRTN3 [inhibition] E2F5 [activation] GLI1 [inhibition] CDC42 [activation] AKT1 [activation] TNFRSF4 [activation] GRB10 [activation] ICAM1 [activation] PAXIP1 [activation] SPP1 [activation] JAK2 [activation] MET [activation] SMPD1 [activation] TUFM [activation;inhibition] ELANE [activation] NFKB2 [activation] SETX [inhibition] RAN [activation] FBLN2 [activation;inhibition] HERC1 [activation] AKAP3 [activation] KCNE3 [inhibition] ESR2 [activation] HSF1 [activation] CREBBP [activation] ASB16 [activation] P4HA2 [activation] NMES1 [activation] NDUFAF3 [activation] CXCR4 [activation] OPRL1 [activation;inhibition] CXCL13 [activation] CBL [activation] CCNB1 [activation] REM1 [activation] DNM1 [activation] CASQ2 [activation] SH2B2 [activation] CD7 [activation] DMPK [activation] GADD45A [activation] PROCR [activation] PIK3CA [activation] CYB5A [activation] EZH2 [activation] SIN3A [inhibition] MLH1 [activation] ARPC1B [activation] GRB2 [activation] NUP62 [activation] NCOA3 [activation] SYK [activation] LILRB2 [activation] PRKACG [activation] NCKAP5L [inhibition] PIK3R1 [activation] DNAL4 [activation] EP300 [activation] ZRSR2 [activation] 页 417 共 454


2016/4/8 19:15

MCCC2 STK4 [activation] GRB2 ABI3 [activation] IKBKB TNIP2 [activation] NOTCH1 APBA1 [activation] TAB3 TAB1 [inhibition] IL1A CAPN1 [activation] RRAS2 CCDC8 [activation] RAC1 BRK1 [activation] FBXO6 ADAM17 [activation] YWHAH NCOA1 [activation] A2M FBXO6 [inhibition] EXOC3 MYC [activation] SKP2 CEBPA [inhibition] TRIM24 AR [activation] FANCF FANCG [activation] BCL2L1 PSEN1 [activation] TTI1 RPTOR [activation;inhibition] EIF4E PRKCB [inhibition] ESR1 ACTB [activation] PSEN1 CFL1 [activation] TRAF6 MAP3K14 [activation] CBL FRS3 [activation] HLA-C GSTM3 [activation] GRB2 GFAP [activation] CDC37 TNFRSF14 [activation] STK32C HSP90AA1 [activation] PLCG1 PAK1 [activation] SMAD9 DKK1 [inhibition] CMTM5 SPATA8 [activation] TEAD1 INSR [activation] LYPLA2 ITGA4 [activation] SRF FHL5 [activation] EFS FYN [activation] E2F3 TFRC [activation] CDKN2A CCDC180 [activation;inhibition] MAP3K3 GNB1 [activation] WEE1 SFN [activation] ACTR3 JUND [activation] STK11 LEF1 [activation] CATSPER1 CHRD [inhibition] RPS6KB1 MAPK9 [activation] TRAF1 TNFRSF12A [activation] CPNE1 STK3 [activation] NCOA3 PRMT1 [activation] BTK TNFRSF10A [activation] XIRP2 RAD21 [activation] TBXA2R GNB2L1 [inhibition] MYO5A SMAD2 [activation] CDK17 APP [activation] GRB14 IGF1R [activation] IGF1R CSK [activation] MIF BNIPL [activation] CHUK PAX8 [activation] BCL3 GSK3B [activation] CDK5RAP2 CDK5 [activation] PIP5K1C IQGAP1 [activation] H2AFX DDX21 [activation] LRRK2 CDK2 [activation] AR SHC4 [activation] HSPB1 PHLDA1 [activation] RAB8A TFRC [activation] TGFBR1 CAV1 [activation] EGLN3 ATF4 [activation] YES1 CDKN1B [inhibition] NUP153 OBSL1 [activation] EMP3 EDA [activation] HSPA2 METTL21A [activation] BLNK TLN1 [activation] HIF1A ATM [activation] HMOX1 ASL [activation] TP53 HMGB2 [activation] TSHB CGA [activation] GRB2 OTUD5 [activation] BIRC2 TNFSF12 [activation] PRKAA1 FSBP [inhibition] POLR2G NTRK2 [activation] 页 418 共 454


2016/4/8 19:15

VASP ABI1 [activation] HIST2H2BF ICAM1 [activation] CREBBP SH3GL1 [activation] ABL1 NEK8 [activation] DDX55 APP [activation] STAM2 LCP2 [activation] ESRRG ESRRA [activation] HSPB1 DNAJC21 [inhibition] SGMS1 STK4 [activation] CRCT1 RGS20 [activation;inhibition] BOC TULP3 [activation] MYOD1 SUV39H1 [activation] TENC1 CSNK1E [activation] TNF TNIP1 [activation] USP34 ATM [activation] SRC AFAP1L2 [activation] C5orf24 PYHIN1 [activation] ZNHIT3 PITX2 [activation] TBX21 SP1 [activation] GJA5 RIMS3 [activation] PPP2R5A CTLA4 [activation] PTPRC INSR [activation] SDC2 HGF [activation] ESR2 PPARGC1A [activation] HIST3H3 FOXA1 [activation] TPX2 IKBKB [activation] TFRC RANBP9 [activation] NCOA4 AKT1 [activation] HSPB1 RSPH3 [activation] GUCY1B3 AGAP1 [activation] CALM1 CALD1 [activation] AR SMAD1 [activation] HDAC3 TWIST1 [activation] HES1 FANCA [activation] MMP3 PLG [activation] CPB2 TINAG [activation] MORN2 MPP3 [inhibition] TLK1 AURKA [activation] HMGCR INSIG2 [activation] BIRC2 PGAM5 [activation] ATF4 RPS6 [activation] NFATC1 GZF1 [activation] PTPN11 STAT3 [activation] YES1 GP6 [activation] SRF NFKB1 [activation] ITGB1 CD82 [activation] F2 SERPINE2 [inhibition] PAXIP1 CD2BP2 [activation] UBA5 SNW1 [activation] APOE PRDX2 [activation] KMT2D CTNNB1 [activation] CLASRP SRPK2 [activation] JAK2 PLCG2 [activation] AR GSN [activation] CTSK FGFR3 [activation] DOK5 RET [activation] ICT1 MRPL15 [activation] CSF2RB IL5RA [activation] BUB1 LEF1 [activation] DOK3 GRB2 [activation] CD40 TRAF5 [activation] TYK2 GHR [activation] CDC5L SMARCA5 [activation] SNAP25 PRKCA [activation] YWHAG FGD6 [activation] FYN DOK3 [activation] CHEK2 KLK7 [activation] DAB2 TRIO [activation] C10orf12 EHMT2 [activation] FN1 F2 [activation;inhibition] EP300 PAX8 [activation] CCND1 RABEP1 [activation] MAP2K5 LNX2 [activation] SH2B2 EPOR [activation] IRS2 SOCS6 [inhibition] SRPK1 NXT2 [activation] 页 419 共 454


2016/4/8 19:15

PARD3 YWHAG [activation] ACTA1 SMARCB1 [activation] DHRS4 TP53 [activation] KCNA2 FYN [activation] DSN1 PIK3R3 [activation] TRRAP MDM2 [activation] FAS ATP6V0B [inhibition] PRKAA1 MARK4 [inhibition] SLC26A3 SLC9A3R2 [activation] RECQL5 BNIPL [activation] JAK3 IKBKG [activation] RNF219 CTNNA1 [activation] MAPT PSEN1 [activation] GSN PTK2 [activation] ABL1 PTPN1 [activation] PSEN1 RAB11A [activation] PIK3R1 PPFIA3 [activation] HSP90AB1 MCM7 [activation] KCNN3 DNM2 [activation] TTC1 SREBF2 [activation] GAPDH OBSL1 [inhibition] STK4 ANXA2P2 [activation] CDC25C MARK3 [activation] GNGT2 GNB4 [activation] SMARCA4 TERT [activation] GNA13 RDX [activation] RAC1 KPNA6 [activation] DDX5 RPA3 [activation] CYTH2 CCDC120 [activation] CDK11A CSNK2A1 [activation] MDC1 RPA1 [activation] VTN EGF [activation] SMAD4 RIPK2 [activation] DAB1 HYAL3 [activation] HSP90AB2P CDK4 [inhibition] TNFRSF11B TNFSF11 [activation] PPP3R1 CABP2 [activation] CFLAR SMAD3 [inhibition] TMSB4X ANXA7 [activation] NTRK2 HSP90AB1 [activation] SEMA3B NRP2 [activation] UBC FOXP3 [activation] AR NSD1 [activation] EGFR RIOK2 [activation] MLH1 SPRTN [activation] SETDB1 S100A10 [activation] LRRK2 NUMA1 [activation] TBPL1 IRAK4 [activation] CRK HLA-B [activation] PLCG2 SH3BP2 [activation] MCM3 MDM2 [activation] SRPK1 PTK2 [activation] CHEK2 MDM2 [activation] EIF2B4 DCC [activation] PDGFRB MFGE8 [activation] ETS1 TLX3 [activation] NRIP1 NR0B1 [activation] MEIS2 C1orf94 [activation] YWHAB TSC1 [inhibition] ARPC4 CTTN [activation] FLT1 PTPRB [activation] ARHGAP1 CHEK2 [activation] STAP1 AR [activation] IRS4 NUDCD3 [activation] MOS DYDC1 [activation] VRK2 MAP2K1 [activation] PDGFB LYVE1 [activation] IQCB1 IQGAP3 [inhibition] RAB34 SMAD4 [activation] PPM1A GRM3 [activation] FANCC FAAP20 [activation] CDC42 OPHN1 [activation] MYC IGF2BP3 [activation] ERCC6 BAZ1B [activation] PRKCA LNX2 [activation] ITGB1 PRKCA [activation] 页 420 共 454


2016/4/8 19:15

APP DYRK1A [activation] ADRB2 PRKDC [activation] FES HSP90AB1 [activation] NUP153 XPOT [activation] RPA2 HNRNPA0 [activation] SIK2 IRS1 [activation] HIPK3 C1QA [activation] TTF1 KAT2B [activation] SNRNP200 STK4 [activation] CREBBP JUNB [activation] SMURF1 JAK1 [inhibition] ABI1 APBB1 [activation] CDON CDH2 [activation] SRY HDAC3 [activation] IKBKB TP73 [activation] AURKB SKA3 [activation] MAPK3 CASP9 [activation;inhibition] MAPK3 FKBP2 [activation] A2M FBXW4 [inhibition] CORO2A DCC [activation] SRF UBE2I [activation] MDM2 SMARCA2 [activation] VHL E2F1 [inhibition] PTBP3 CDK2 [activation] TNFRSF4 TRAF5 [activation] NR3C1 SUMO1 [activation] ESR1 IRS2 [activation] NUP93 ARF6 [activation] HDAC1 NKX2-2 [activation] ACTB ERG [activation] CASP8 AGR3 [activation] CENPF LRRK2 [activation] CTSC SUMO1 [activation] HIST1H3A PAK1 [activation] XIAP BMPR2 [activation] SLC6A9 IGHG1 [activation] PTPN6 ZAP70 [activation;inhibition] NFKB1 HSPA4 [activation] APP ADAP2 [activation] SHC1 CBLB [activation] SASH1 IKBKB [activation] G3BP1 ITGA4 [activation] KIFC3 BCL6 [activation] RGL2 NOTCH2NL [activation] NEDD8 RAN [activation] HSP90AB1 INSRR [activation] FLNB TRAF6 [activation] APPL1 PLEKHF2 [activation] TPD52L1 TPD52L3 [activation;inhibition] NCOA3 PTEN [activation] GRB2 HNRNPC [activation] NLRP4 CHUK [activation] MAP4 PIK3R1 [activation] MLLT4 ITGA4 [activation] TNFRSF14 HNRNPL [activation] BCR HCK [activation] CSNK2A1 IFRD1 [activation] YWHAH TIAM1 [activation] PHACTR4 GRB2 [activation] SUPT6H CDKN1A [activation] MAP2K6 PLCB2 [activation] HNF4A SREBF2 [activation] PIAS1 ARID3A [inhibition] SRC LYN [activation] EGFR DOK6 [activation] TGM2 SMAD2 [activation] BTRC NXF1 [activation] SKP1 CRY1 [inhibition] FOS CHMP3 [activation] CAPN2 HNRNPA1 [activation] RPS6KA4 MAPK1 [activation] JUND ETS1 [activation] DSTN GH1 [activation] PIK3CG GSN [activation] DCN AHSG [inhibition] ANXA2 OBSL1 [activation] 页 421 共 454


CAMK2G DNAJB2 FLNB RYR1 CYTH3 PPP2R1A MAPK14 FER CD247 FAM98B CASP6 CBL CARF RAD50 CREBBP ADRB2 STX2 ULK1 TNS1 SMARCA5 SRC CBL TTI2 TULP1 NXF1 JAM2 UBE2E3 CSPG4 H2AFX MCM3 CDC25A ITSN2 MAP3K8 RPS28 MAPK1 HSPA4L IRF3 LATS1 SUMO2 RIPK2 CCDC14 ITGA4 RPTOR RPRD1A MAP3K11 ID4 DDX54 PRDM2 RALGAPB VASH1 AVEN HIF1A NAB1 VDR PGLYRP1 STK3 KALRN EIF4A3 ANGPTL4 CDC5L ANAPC5 RICTOR PARD3 CDK11B MYC PLEKHG5 HNRNPR UBE2I FYN EP300 PPP2R2B TAOK3 MAST1 CASP7 YWHAQ MARK2

2016/4/8 19:15

CHAT [activation] ERBB2 [inhibition] GRB2 [activation] PRKACA [activation] CCDC120 [activation] FECH [inhibition] HDAC3 [activation] CDH1 [activation;inhibition] NLGN1 [activation] CD81 [activation] PRKAB2 [activation] WAS [activation] APP [activation] EP300 [activation] CDK2 [activation] PCBP2 [activation] SNAP25 [activation] SESN2 [inhibition] MET [activation] BAZ2A [activation] CDCP1 [activation] NTRK1 [activation] RPAP3 [activation] NCK1 [activation] TAGLN2 [activation] TJP1 [activation] RNF166 [activation] GRIP2 [activation] ANXA2 [activation] ITGA4 [activation] HLA-C [activation] EGFR [activation] HSP90AA1 [activation] ITGA4 [activation] SREBF2 [activation] ARF6 [activation] CREBBP [activation] KRT31 [inhibition] MYO1B [activation] TRAF1 [activation] MAPK14 [activation] HP1BP3 [activation] YWHAQ [activation] GSTK1 [activation] MAP2K4 [activation] HES1 [activation] PGR [activation] HIST1H3A [activation] RALGAPA1 [activation;inhibition] CCDC23 [activation] BCL2L1 [activation] DNAJB1 [inhibition] EGR1 [activation] JUN [activation] HSPBP1 [activation] STK4 [activation] NDEL1 [activation] RPS6 [activation] ITGB1 [activation] PPP2R1A [activation] TP53BP1 [activation] FBXO9 [activation] CDH5 [activation] HSPA4 [activation] YWHAB [activation] LNX2 [activation] BMPR2 [activation] WNK1 [activation] CNN3 [activation;inhibition] SREBF2 [activation] CHEK2 [activation] LRRK2 [activation] DNAJB1 [inhibition] CAST [inhibition] GRB2 [activation] AURKB [activation] 页 422 共 454


2016/4/8 19:15

TSPAN12 TFCP2 [activation] SCHIP1 FOS [activation] CASP7 RASA1 [activation] NUAK1 IGHA2 [activation] PSAT1 TIMP2 [activation] BLNK CRKL [activation] FGFR2 YWHAZ [activation] TSC2 DAPK1 [activation] ECSIT SMAD4 [activation] NECAB2 ADORA2A [activation] FYB PRKCQ [activation] RBPJ SNW1 [activation] HIST3H3 HDAC1 [activation] CBX1 HSPB1 [inhibition] EGFR CD59 [activation] IQGAP2 RHOG [activation] JUN MTA3 [activation] MDM2 NUMB [activation] RB1 AURKB [activation] EGLN2 TRIP6 [activation] VCAM1 MCM5 [activation] KAT2A IRF1 [activation] NDEL1 CWF19L2 [activation] MYOD1 SETD3 [activation] ADRB2 DSG2 [activation] DCN ELN [activation] LRRK1 FLT4 [activation] RPS17L NUDC [activation] ENOX2 TRAF5 [activation] RASA1 PIK3R1 [activation] USP7 CRKL [activation] FLNB RAC1 [activation] SNRNP70 VCAM1 [activation] CDK5RAP2 PCNT [activation] SMARCA4 VDR [activation] PLCH1 EGFR [activation] UBE2E3 RNF181 [activation] PLK1 MYT1 [activation] JUN PIAS2 [activation] EIF5 DUSP12 [activation] ACSF2 CMTM5 [activation] F2R F2 [activation] EGFR SGSM2 [activation] F2R F2RL2 [activation] RELA TAF1 [activation] CTU1 HSPA4 [activation] NXF1 SETDB1 [activation] THRB RXRA [inhibition] NR2E3 RBL1 [inhibition] CDKN1A ABR [activation] CYBB ACTB [activation] KLHL40 FAM208B [activation] CHUK CUL1 [activation] HSPB1 PTGES3 [activation] WEE1 PIN1 [inhibition] MDM2 C1orf173 [activation] PYCARD IL6ST [inhibition] EPAS1 ARNTL2 [activation] NXF1 CEP78 [activation] RELA NCF1 [activation] PLEKHB2 C1orf94 [activation] ZDHHC17 GATA1 [activation] TH MAPKAPK2 [activation] APP IL15 [activation] GRB2 UGP2 [activation] EGFR PANK4 [activation] ACVR1 NUAK2 [activation;inhibition] MAPT TRAF6 [activation] MMP9 MMP10 [activation] AASDHPPT TRAF2 [activation] RICTOR TIA1 [activation] BRD7 TRIM24 [activation] CASP3 CRYAB [activation] CXorf56 PDCL2 [activation] ARNTL UBE2I [activation] SRPK1 MAGOH [activation] 页 423 共 454


2016/4/8 19:15

SASH3 SMAD7 [activation] LYN ITGB2 [activation] IQSEC1 GNAQ [activation] CTSG AGT [activation] FBXL2 PIK3R1 [activation] IGF1R SOCS2 [inhibition] IL15RA CDK2 [activation] DCN EGFR [activation] TXNDC5 NOTCH2NL [activation] ATRX PRKDC [activation] TTN RAPGEF2 [activation] ASS1 JAK2 [activation] RPS8 TP53 [activation] TNF RALBP1 [activation] TWIST1 RELA [activation] TP53 GTF3C3 [activation] LRRK2 KPNB1 [activation] PLK1 NEDD9 [activation] PRKCD AFAP1 [activation] CAPZB TRAF6 [activation] PPARGC1A TP53 [activation] PYCARD NAA15 [inhibition] STK4 SMR3B [activation] SNAI1 XRCC3 [activation] HLA-B MCM7 [activation] PPP2R5A PYGM [activation] TIMP2 RAB3A [activation] GRB2 PIK3CG [activation] AR YWHAH [activation] SIK2 PRKAA1 [inhibition] PTK2 EPHB2 [activation] BANP MAX [inhibition] CUL1 KDR [activation] CDC26 FBXO5 [activation] DVL1 EPS8 [inhibition] HSP90AB1 PTK6 [activation] GRB2 HNRNPR [activation] CDH1 GBAS [activation] NXF1 NOTCH2NL [activation] SIPA1 FMNL1 [activation] RHOB FBXO42 [activation] TNFSF9 IRAK2 [activation] DENND3 MYC [activation] TP53BP1 LRRK2 [activation] PRNP LSAMP [activation] TMED2 F2RL1 [activation] PIK3R1 FGFR1 [activation] AURKB PLEKHA5 [activation] PIK3R4 YWHAB [activation] IL6ST JAK2 [activation] PDZRN3 BMPR2 [activation] IRS1 TYK2 [activation] IRS1 LRRK2 [activation] CAPN1 CAPNS1 [activation] PTK2 CSK [activation] TLR3 PIK3R1 [activation] TNIK MYL12A [activation] C9orf156 RB1 [activation;inhibition] STX6 ENO1 [activation] FBN3 GADD45A [activation] AR CALM1 [activation] ANKRD53 LZTR1 [activation] MAPK14 EPB42 [activation] XIAP BMPR1B [activation] RARA HDAC1 [activation] MYL6 NFKB1 [activation] RAD54B CDC23 [activation] PTK2 ACTN1 [activation] KMT2A MYC [activation] S100A16 NXF1 [activation] MBP MAP3K3 [activation] IKBKB MARK3 [activation] JUND SMAD4 [activation] IRF2 KAT2B [activation] SLC25A6 NOTCH2NL [activation] HCK MAP4K5 [activation] 页 424 共 454


CD247 DAB2 SPRY2 PTPRG ACP1 RAD21 ABI2 SPP1 FCN1 MAP1A DNM2 NAPA HSPB1 PRKCA MAP2K7 ARRB2 PRKCD ATF2 MDM2 PCNA VAV3 ACTG1 CTSG MLH1 LAMA5 CFTR RELA H2AFX SRSF6 YWHAB STAT5B EPHB6 MS4A1 JADE2 TRAF2 ORC2 STK38 A2M NLRP3 APEX1 ESR1 TRAP1 SET HNRNPL CRY1 CDC25C HEATR2 FBN3 PLD1 DAB1 CD2BP2 GRK4 SRC PRKAR1A FEM1B PML MOK STK3 TP53BP1 CAPZA2 CCR1 SMAD4 ETS1 BCR SORT1 SRPK2 FAM208B EIF4A1 MAPK8 HIF1A FYN GH1 APP VCAM1 THRB GNAZ

2016/4/8 19:15

GNAI2 [activation] ACOT9 [activation] MAPK1 [inhibition] TEK [activation] PAK2 [activation] RPA1 [activation] ADAM29 [activation] SLC39A6 [activation] ELN [activation] GRB2 [activation] VAV1 [activation] SNAP25 [activation] WDR66 [activation] ACTA1 [activation] ALK [activation] ERH [inhibition] HSPB1 [activation] PTPN1 [activation] ESR2 [activation] SETD8 [activation] GRB2 [activation] TAB2 [activation] VCAM1 [activation] CYLC2 [activation] FBXO6 [inhibition] PLD2 [activation] HSPA9 [activation] RAD17 [activation] TP53 [activation] IRS2 [activation] FGFR2 [activation] HSP90AA1 [activation] LCK [activation] PACSIN1 [activation] ZC2HC1C [activation] CCL2 [activation] CALM1 [activation] KLK2 [inhibition] MAVS [inhibition] TP53 [activation] STAT3 [activation] OBSL1 [activation] GZMA [activation] TP53 [activation] PER2 [inhibition] BRSK2 [activation] MYC [activation] ANXA7 [activation] PEA15 [activation] VENTX [activation] RAD54B [activation] HSP90AB1 [activation] EP300 [activation] CDH2 [activation] CHEK1 [activation] RUNX1 [activation] MAPK6 [activation] RAE1 [activation] NFKB1 [activation] DAPK1 [activation] CCL23 [activation] CAMK2G [activation] CREBBP [activation] IRS1 [activation] ELAVL1 [activation] RBM23 [activation] MORN3 [activation] GABARAPL2 [activation] PIK3R1 [activation] TRAF6 [activation] CDC27 [activation] DNAJC8 [inhibition] WHSC1 [activation] ESYT1 [activation] TP53 [activation] NMT1 [activation;inhibition] 页 425 共 454


2016/4/8 19:15

APH1A THPO [activation] BMX BTK [activation] CDKN1A ESR1 [activation] PDGFRB PTPRB [activation] GP2 ANXA4 [activation] BAZ2A FYN [activation] GABARAPL2 ATG10 [activation] EIF2AK2 HIST2H2AC [activation] STAT3 PTPN1 [activation] TRAF1 CASP10 [activation] HIST1H1A PRKCB [activation] LIN37 RBL2 [inhibition] CXorf57 DNAJA4 [inhibition] FERMT3 ITGA4 [activation] KCNE3 POLA2 [activation] NR0B1 ESR2 [activation] BAG3 GNAO1 [activation;inhibition] UVRAG PIK3C3 [activation] SKI GLI2 [inhibition] IGSF1 INHBB [activation] SRSF7 SRPK2 [activation] SNAP23 STX6 [activation] ABL1 NBEA [activation] ICAM1 HIST1H1C [activation] MMP9 MMP7 [activation;inhibition] BIRC3 E2F1 [activation;inhibition] USHBP1 CCDC87 [activation] IQGAP1 MAP3K3 [activation] ATM CREB1 [activation] PLCG1 CD22 [activation] MAPK1 PML [activation] RHOC ATF2 [activation] TWIST2 TP53 [activation] ITGA4 EIF3A [activation] TRAF6 C19orf10 [activation] BCAR1 GRB2 [activation] LRRK2 NFATC2 [activation] NOX1 NOXA1 [activation] CHEK1 NEK9 [activation] ITGA4 NUDC [activation] AHNAK AKT1 [activation] TSC22D1 PRKCI [activation] FGFR1 HTR1A [activation] NLK FAM222A [inhibition] CBX8 SPAG9 [inhibition] EFNB2 PECAM1 [activation] PLSCR2 EP300 [activation] ICAM1 CCT3 [activation] GMPS HLA-C [activation] PIK3R1 DAG1 [activation] FAS SUMO1 [activation] MRAS SHOC2 [activation] SMAD1 GSK3B [activation;inhibition] CBLB CFLAR [inhibition] TLN1 DAG1 [activation] PRNP BAZ2B [activation] SETDB2 IGHG1 [activation] CD46 C4B [inhibition] TFDP2 RB1 [inhibition] UBE2A TP53 [activation] CITED2 EP300 [activation] MAPK9 EEF2K [activation] SPATA24 LRRK2 [activation] RAB21 HLA-B [activation] RABGGTB RAB11A [activation] YWHAG GRB2 [activation] STAT3 MRPS31 [activation] MPRIP RPA3 [activation] CREBBP RPS6KA5 [activation] RAC1 FMNL1 [activation] ABCC8 ENSA [activation;inhibition] FAM154A MVP [activation] TRAF6 EIF2S3 [activation] JUN ITCH [activation] SRPK2 NUP50 [activation] PBK CCNB1 [activation] 页 426 共 454


SP1 ETS1 NUP54 APC INHBA CHRDL2 SPAG9 EIF4A2 SRC FGR CASP8 ST14 PDPK1 PTK2B ARPC4 NXF1 PMS1 HELB RB1 CCDC180 SRPK3 LUC7L CRIP2 RELA FBP1 BCL2L1 POLR2G PRKRA MYC SIRT6 BLNK ITK INPP5K PYGM LIN9 LIN52 GRB2 HSPG2 MAPK13 PPA1 NUP210 CDK1 CHN1 BMPR1B CDK19 PIP TNIK ANXA2 BAG3 CRKL MYC ECT2 HIF1A AR HDAC1 KCTD11 STAC3 WHSC1L1 MYO10 FBXW11 GABARAPL2 CCNG1 TNIP1 VTN TGFB1 GBP3 MAP4K4 SP1 TPI1 CRK PHACTR2 ATF2 ITGB1 CFLAR SPATS1 AKT1 PI4K2B DIAPH1 SRGAP2 C12orf65 GCG MEP1A SHOC2 ERBB2IP TRAF6 SDCCAG8 RFX6 CCNK EP300 TBX21 STK4 CKAP5 VIP SGTA PRKCA HAND1 SLC52A2 ADRB2 JAG1 UBC PRKACA CIITA FGFR4 CASC3 CS HLA-B ANKRD1 TULP3 DGCR8 MAPK1 CRAMP1L RASA4 ZAP70 SH2B3 MIDN GADD45G CDC20 TP73 SSTR5 CORT MDC1 RAD51 ARF6 PSD4 HSPA1L NFKB2 HSPA6 RPAP3 NOXA1 MAPK1 BARD1 YWHAZ CD5 FYN HSPA8 JUN PAX6 NKIRAS2 FAM86A FAM86B2 TF IGF1 TBXA2R PTGIR RBBP8 MRE11A NCKIPSD RAC1 CYTH3 CYTIP

2016/4/8 19:15

[activation] [activation] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] SMARCB1 [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] APP [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] 页 427 共 454


2016/4/8 19:15

RUNX1 TLE1 [activation] EIF4A2 CMBL [activation] TRAF6 KIR2DL4 [activation] HSPA8 REL [inhibition] NCOA3 PRKCZ [activation] STX16 VTI1A [activation] NCKAP1 SPP1 [activation] TERF1 PFN2 [activation] BEST1 PPP2CA [inhibition] IKBKB EPRS [activation] RALGAPB DHX15 [activation] YWHAZ IRS4 [activation] SNURF SRPK2 [activation] ASIC3 PRKACA [activation] GABARAPL2 U2AF2 [activation] BHLHE40 UBE2I [activation] ESR2 DDX5 [activation] LRRK2 AKT1 [activation] CD4 LGALS1 [inhibition] TIMELESS CRY2 [activation] BLK HSP90AA1 [activation] C4B CFB [inhibition] FOXI1 APP [activation] APBB1 DIAPH1 [activation] TRAF2 TNFRSF12A [activation] MET SOCS5 [inhibition] CDK2 MYOD1 [activation] STX11 APP [activation] ARF6 RABGAP1 [activation] RB1 IRF3 [inhibition] LUC7L2 NDUFA4L2 [activation] FAS EZR [activation] B2M TFRC [activation] MAPRE3 APC2 [activation] HIVEP1 MAPK14 [activation] COPA EGFR [activation] FGFR1 CDC20 [activation] GAS7 CYFIP1 [inhibition] ZNF106 SMAD2 [activation] CYFIP1 PPP1CC [inhibition] ACKR4 CCL2 [activation] GABARAPL2 HSP90AB1 [activation] SRPK3 SNRPA [activation] WIBG LRRK2 [activation] CD38 CD3E [activation] GEM GMIP [activation] GNAI2 LHCGR [activation] APP SMURF1 [inhibition] GABARAP HSPH1 [activation] NR4A1 POLA2 [activation] STAT1 NFKBIA [activation] EIF2B4 EGFR [activation] RASSF3 STK3 [activation] CASP7 PSIP1 [activation] HCK SPRR2A [activation] EGFR RNMTL1 [activation] GH1 GLRX3 [inhibition] SMAD5 ANKRD13A [activation;inhibition] RRP1 GABARAPL2 [activation] TRAF6 XIAP [activation] EP300 PRDM6 [activation] UGT1A3 UGT1A8 [activation] HSP90AB1 SRPK1 [activation] RAN NSMF [activation] CD81 CD82 [activation] EIF4EBP3 CDKN1A [activation;inhibition] EGLN3 MAPK6 [activation] ESR1 AKT2 [activation] DYRK1A ISG15 [activation;inhibition] BLZF1 BCL6 [activation] WAS NCK1 [activation] HCK MET [activation] TLR4 EGFR [activation] PRKCA NXF1 [activation] ADIPOR1 APPL1 [activation] STAG1 STAG2 [activation] 页 428 共 454


2016/4/8 19:15

GNB1 ARHGEF18 [activation] PLCG1 VAV3 [activation] HMGN1 PRKACA [activation] MYLK ACTC1 [inhibition] INSR GNB2L1 [activation] CSNK1G2 APP [activation] SKP2 RASSF1 [inhibition] TKT FTSJ1 [activation] TGFB1 CCL5 [activation] DCN MMP2 [inhibition] GZMA GOLGA2 [activation] FOXC1 HMGB1 [activation] PAFAH1B1 DNAI1 [activation] IGKC IGHG4 [activation] CAPN1 FANCC [activation] E2F1 NRIP1 [activation] NRAS SMAD1 [activation] DAB1 C1orf51 [activation] MYL6B IQGAP1 [activation] MOS LZTS2 [activation] PIK3CA APPL1 [activation] RPS24 VCAM1 [activation] BMX ERBB2 [activation] PRKDC JUN [activation] SMAD1 RAB2B [activation] NRBP1 PPP1CC [activation] SS18 GRB2 [activation] RANBP1 EGFR [activation] ANGPTL7 APP [activation] FGFR3 ARAP1 [activation] THPO MPL [activation] PPARG PIN1 [activation] GRB2 RIF1 [activation] CCDC70 GOLGA2 [activation] PTEN INHBE [activation] KRT36 GRB2 [activation] ANXA2 ERBB3 [activation] HLA-E PPP1R16A [activation] PIK3CA GSN [activation] XRCC1 OGG1 [activation] BCCIP ITSN2 [activation] IKBKB HSPA9 [activation] CASP3 RAD51 [activation] CRK HSPA5 [activation] VGLL4 MEF2A [activation] PLK1 C9orf114 [activation;inhibition] PLK1 DIXDC1 [activation] CFTR SNAP23 [activation] CDC42 LRRK2 [activation] RCVRN IL15RA [inhibition] RALA CALM1 [activation] YAP1 AKT1 [activation] STAT3 FOXM1 [activation] ARPC3 CETP [activation] NOL12 CDK4 [inhibition] CCDC121 USHBP1 [activation] EEF2K MAPK11 [activation] ATG7 SUMO2 [activation] PAX6 LHX2 [activation] SGK1 CS [activation;inhibition] RGS20 ABHD17A [activation;inhibition] RICTOR TUBB [activation] ITK ERBB2 [activation] NKX2-1 RARA [activation] TRMT112 RGS20 [activation;inhibition] VCAM1 CTSH [activation] PAXIP1 ANAPC5 [activation] IQSEC1 APOE [activation] LRRK2 PHB [activation] TNIK MACF1 [activation] PIAS2 PAXIP1 [activation] IRF3 DDX58 [inhibition] FANCL ACVR1 [activation] FOXO1 YWHAZ [activation] VRK2 RAN [activation] IRF3 TMEM173 [activation] 页 429 共 454


SFN BAD RB1 SETD7 PYHIN1 BAZ1B BORA BTRC CABP4 CACNA1F AGFG1 XPO1 APP GSN XPO6 STK4 SMC2 TFE3 RAD51C HRNR TRIM25 APC CAPN2 PTPN1 FAM111B NXF1 NXF1 ATG16L1 SLX4 DDX24 CDH13 CCND1 ANKRD27 VAMP7 KCNH1 CALM1 MAPKAPK5 ARL8B ELAVL1 DNM1L CDC5L TRAPPC5 A2M HSP90AB1 TGFB1 ITGB8 SRPK2 SRSF2 PRR14L PPP2R1A TP53 GAPDH PIP5K1C TLN2 DLG2 FZD4 CDH1 FGFR1 LRRK1 CBLB BARD1 DDX39B NR3C1 STIP1 GRB2 RCC2 GAK BAG5 PDGFRB VAV2 AKAP8L ILK NCF4 PRKCD DDR2 SHC1 MRPS23 ICT1 PIAS1 MSX1 LRRK2 PTGS2 RIMS1 CACNA1C NFYB DRAP1 REL PTK6 SENP2 AGTRAP JAK2 YES1 SH3RF2 RAC1 VEGFA AKT1 UBE2H RELA USP7 ATG10 GNAO1 HRH4 RXRA NR1H2 PLCG1 GLTSCR1 MKNK1 MAPK11 EVL FYB RAB5A VPS45 YWHAG PARD3B VCAM1 EIF4H DOCK8 MYD88 HNRNPA1 MRPS27 BTK DAPP1 PRKAA2 PRKAA1 MYLK MAPK3 NR5A2 NSD1 CASP8 RFFL PRELP COL1A1 CDC37 PRKAA1 ANXA1 DLAT SUMO1 RAD54B CRK DLGAP2 SMAD4 FBP2 RPA3 PRPF6 HOXB4 CREBBP TTPAL TGFBR1 ANAPC1 FZR1

2016/4/8 19:15

[inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] EEF2K [activation] [activation] [activation] [inhibition] KLHL26 [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [inhibition] [activation] [inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] 页 430 共 454


2016/4/8 19:15

CPN1 CDC42 [activation] TOP3A TP53 [activation] TRIM54 ARHGEF5 [activation] NR3C1 AR [activation] NFKB1 SIRT1 [activation] RAB10 RPA3 [activation] KSR1 PPP2R5A [activation] CTNNB1 EZH2 [activation] ARRB1 YES1 [activation] SMG7 TP53 [activation] NXF1 BMS1 [activation] ANXA7 A2M [inhibition] RPA1 SLFN11 [activation] SYP GRB2 [activation] SNCA YWHAE [activation] DYNC1H1 NF1 [activation] PRKCA VTN [activation] IKBKG RHOA [activation] NR4A2 EIF3A [activation] PHLDA3 SAAL1 [activation] SRPK3 HSP90AB1 [activation] CDCA8 GAS2L3 [activation] EPSTI1 ESR1 [activation] ACTN4 ICAM1 [activation] MYO1B CCDC8 [activation] NOTCH2NL HPCAL1 [activation] CSNK1D CSNK1E [activation] CBL GAPDH [inhibition] HIST2H2AB SMARCA5 [activation] PRKACA THOP1 [activation] HSPE1 TNFRSF14 [activation] PLK1 DVL2 [activation] OBSL1 HIST1H4A [activation;inhibition] ACTB PFDN1 [activation] ROCK1 LIMK1 [activation] UBL4A VAPB [activation] PECAM1 ABL2 [activation] CACNA1A HSPG2 [activation] CBL PTPRG [activation] CTCF THRB [activation] ADRB2 RGS2 [activation] RHOG PLD1 [activation] FOXP2 MAPK3 [activation] HTR2A GNAI1 [activation] CFL1 SSH3 [activation] CAV1 ABL1 [activation] MCM6 ITGA4 [activation] TRAF6 NAA50 [activation] TP53BP1 EP300 [activation] PRKAA1 EIF5B [inhibition] KMT2A SVIL [activation] SMEK1 MAPK14 [activation] ACTN1 KCTD6 [activation] STK3 STRN [activation] CCDC102B FAM127B [activation] PTPRJ NTRK1 [activation] IL4R IL2RG [activation] INS NOV [activation] VCAM1 CSNK1A1L [activation] CAPN1 TIRAP [activation] TP53 PHKG2 [activation] HIST1H3A PRMT5 [activation] NEDD8 EIF2A [activation] SP1 EP300 [activation] CD44 ATF2 [activation] NBAS OLFM2 [activation] LAS1L ETS1 [activation] FMNL1 PPP1R12A [activation] DVL2 SIRT1 [activation] C2orf47 LYN [activation] YWHAB PLEKHA5 [activation] GABARAPL2 G3BP2 [activation] GRB2 KRT32 [activation] GEM KRT31 [activation] PRKCA TYK2 [activation] MYB ZFHX3 [activation] 页 431 共 454


2016/4/8 19:15

SHC1 STAT5A [activation] PHYHIP HNRNPA1 [activation] INHBB ACVR1B [activation] FKBP1A SMAD6 [inhibition] MAPK6 MAP3K12 [activation] GRAP FYN [activation] ACTG1 MYOC [activation] EIF2S2 PAXIP1 [activation] BMP1 CHRD [activation] NBN MLH1 [activation] FAM53C YWHAZ [activation] TRAF2 EP300 [activation] PRKDC WHSC1 [activation] CAMK2B HSP90AA1 [activation] CCNA1 KLHDC9 [activation] HMGB1 PLG [inhibition] DNM3 FYN [activation] CDH1 ERBB2IP [inhibition] STAT1 EIF1AD [activation] PXDN FBXO6 [inhibition] SH2D1A EGFR [activation] FANCE PCNA [activation] MYC HCFC2 [activation] ATF4 CCDC106 [activation] KITLG CMA1 [activation] FANCA FAAP20 [activation] MTOR GPHN [activation] CSNK1E ZSWIM8 [activation] YWHAE TSC2 [activation] JUN PPARG [activation] FZR1 BRSK2 [inhibition] IKBKB COPS3 [activation] ICK RPTOR [activation] HSP90AB1 METTL22 [activation] NXF1 ITPA [activation] HOPX TLX3 [activation] VRK2 BCL2L1 [activation] ATG12 ATG5 [activation] NR3C1 GNB1 [activation] UGT1A10 UGT1A1 [activation] TRAF2 CD27 [activation] ABL1 POLR2A [activation] HMGA2 SMAD9 [activation] ATF4 NDC80 [activation] TNFRSF10A TRADD [activation] CTSG KNG1 [activation] SOX2 HSPB1 [activation] PDHB ITGB1 [activation] IL1F10 IL1R1 [activation] RAVER1 AURKB [activation] EGLN2 EGLN3 [activation] XPO5 NUP153 [activation] PCNA HLA-B [activation] ACTN1 HSP90AB1 [activation] UTP15 EGFR [activation] MAPK9 MAPKAPK5 [activation] NOX1 TNFRSF1A [activation] TP53 WDR48 [activation] GPANK1 GRB2 [activation] PAK1 GNB1 [activation] DYSF DHX15 [activation] YWHAZ IL9R [activation] HSPB1 HNRNPH2 [activation] SRPK2 LZTS2 [activation] SAMHD1 CD81 [activation] CASP8 PARP2 [activation] ECSIT PSEN2 [activation] MRFAP1L1 RADIL [inhibition] CCDC28A SRPK2 [activation] SMAD1 YY1 [activation] NR3C1 CEBPA [activation] FECH ATM [activation] EIF2B4 EIF2B2 [activation] ITGA4 MCM5 [activation] TENC1 CAV1 [activation] FGF2 VTN [activation] 页 432 共 454


2016/4/8 19:15

SUMO1 TNS3 [activation] ADRBK1 GRM1 [activation] PIK3CG UTRN [activation] TRIM50 UBE2E3 [activation] PIN1 FOXO4 [activation] SYT5 NRXN1 [activation] PLCG1 FAS [activation] MEOX2 TRAF6 [activation] LCN2 HGF [inhibition] KATNA1 CD40 [activation] FANCG POLN [activation] FYN HTR6 [activation] GABPA CREBBP [activation] CDK4 CAMK1 [activation] NOTCH2 EGFL7 [activation] TNFRSF1A SLC25A6 [activation] CRKL CBLB [activation] RNF11 UBE2E2 [activation] RNF114 MAPK3 [activation] CNTNAP1 KCNA1 [activation] MTMR9 MOS [inhibition] GPS2 CCNA1 [inhibition] NMRAL1 ASS1 [activation] PPP2R1A TRAF6 [activation] RND3 ROCK1 [activation] HDAC1 MAPK8 [activation] CASP3 XIAP [activation] FCN2 LRP1 [activation] RELA TBP [activation] PRKAA2 ULK1 [inhibition] ATP1A1 SMAD2 [activation] DOCK6 LRCH3 [activation] APP MTERFD2 [activation] HLA-B RAB6A [activation] MAPK14 ZNHIT1 [activation] FEM1B APAF1 [activation] ULK1 ATG4B [inhibition] IL17RB RPS6KA5 [activation] GRIA2 GRIK5 [activation] GAPVD1 RAD21 [activation] AKR7A3 AKR7A2 [activation] PRKAA1 PA2G4 [inhibition] NFKBIA SLC25A4 [inhibition] FOS RUNX1 [activation] MAPRE1 MAPRE3 [activation] ASB15 MIF [activation] BMF MAPK8 [activation] CDC37 RHOBTB2 [activation] RUNX2 TP53 [activation] NBN NAT2 [activation] C5AR1 ARRB2 [activation] TP73 PRKACA [activation;inhibition] IRAK1 MBP [activation;inhibition] MLH1 CCDC180 [activation] PKIB PIN1 [inhibition] HIST1H1D ICAM1 [activation] PPP3CA JUN [activation] NR4A1 PLXND1 [activation] HLA-C MAPRE1 [activation] FZR1 UBE2D1 [inhibition] CTU2 URM1 [activation] TSSK1B TGFBR2 [inhibition] TP53 ANXA7 [activation] YWHAE HDAC4 [activation] PPARA EP300 [activation] PDIA4 GADD45G [activation] LSM10 BMPR2 [activation] ANAPC11 ANAPC4 [activation] HNRNPA0 MAPK6 [activation] GRB2 PEX13 [activation] DDX39B BMI1 [activation] IRS4 GBF1 [activation] PRNP MTG1 [activation] ABL1 C6 [activation] STK4 GABARAPL2 [activation] BTRC IKBKB [activation] 页 433 共 454


2016/4/8 19:15

YWHAB CRTC3 [activation] GSTM3 TRAF6 [activation] SMAD2 ST5 [activation] LARP4B CDK18 [activation] EHMT2 HIST1H1E [activation] CASP3 ELAVL1 [activation] SMURF1 RHOB [inhibition] PRKCA RHO [activation] NLRP3 PYCARD [inhibition] CSDE1 PAK2 [activation] BCL3 MAPK3 [activation] GEM TFAP4 [activation] EP300 SEPP1 [activation] B2M HLA-E [activation] CDC5L DDX17 [activation] PPP1R12A RPA3 [activation] MAPT LRRK2 [activation] GRB2 EPHB2 [activation] HAPLN1 MMP9 [activation;inhibition] H2AFX ATF2 [activation] TOP1 H3F3A [activation] TXNDC11 RPS6KA5 [activation] RAF1 RALGDS [activation] CDH1 NANS [activation] C6 MGEA5 [activation] PYHIN1 GPC4 [activation] ELANE YARS [activation] CTNNB1 ETS1 [activation] NCK2 FYB [activation] TUBB DPYSL2 [activation] C16orf80 LRRK2 [activation] PPAP2B CTNND1 [activation] AR NFKB1 [activation] LIN54 TFDP2 [inhibition] IQGAP3 PASK [inhibition] AKT1 PMS2 [activation] HLA-B LRRC40 [activation] CYGB DDI1 [inhibition] CYLD TRPA1 [inhibition] YWHAB R3HDM1 [activation] SSU72 RAD21 [activation] DEFA1 DEFA3 [inhibition] SHC1 DAG1 [activation] TFE3 HMGB1 [activation] PCSK1 REN [activation;inhibition] RAD52 RAD51 [activation] DAB1 PIN1 [activation] NRAS XPA [activation] LRMP WNK1 [activation] FLOT2 OBSL1 [inhibition] LYN C21orf59 [activation] NCK1 ASAP2 [activation] TNFRSF1A TRAF3 [activation] CALCOCO2 SHC1 [activation] RNPS1 SRPK1 [activation] KAT5 FOXP3 [activation] PTPRB MAPK1 [activation] RASIP1 ARFGAP1 [inhibition] GRB2 PPP5C [activation] NOTCH1 TGFBR1 [activation] IKBKE GRB2 [activation] TCOF1 ICAM1 [activation] PER2 TP53 [activation] STRAP NXF1 [activation] NUAK2 LATS1 [inhibition] UBE2U RNF41 [activation] L1CAM ITGAV [activation] STK24 G3BP2 [activation] AKT1 CTNNA1 [activation] U2AF2 DDX17 [activation] CDK6 ZSCAN1 [inhibition] MYO1B MAP3K3 [activation] PTN CACNB4 [activation] GSK3B ZFPM1 [activation] NRIP1 MAP3K7 [activation] TSACC FOXP2 [activation] 页 434 共 454


2016/4/8 19:15

H2AFX EGFR [activation] XCL1 KRTAP10-11 [activation] IGHM BTK [activation] HDAC3 STAT3 [activation] ITGA4 HIST1H1C [activation] PPP2CA ERBB2 [activation] CDH1 HDAC1 [activation] DUSP10 FHL2 [inhibition] EHMT2 MX2 [activation] CREBBP BCL6 [activation] PRKCA PPARA [activation] BTRC NUMB [activation] MAPK10 SH3BP5 [activation] ITCH UBE2E2 [activation] EEF2K CDK1 [activation] HSP90AB1 CTNNB1 [activation] LYZL1 XAGE3 [activation] RHPN1 CNKSR1 [activation] TRAF6 APEX1 [activation] ELK1 EMX1 [activation] ADRBK1 PDGFRB [activation] NOTCH1 SMARCC1 [activation] BCAR3 ANXA2 [activation] HIST1H1A LIMK1 [activation;inhibition] ADAM17 TGFA [activation] DPYSL3 LRRK2 [activation] SIRT6 PRKDC [activation] CDC7 CDKN1A [activation] CRK DLX4 [activation] RPA3 RAD21 [activation] ITGA4 CAPZA1 [activation] OPRK1 GPRASP1 [activation] TFRC HFE [activation] CTNNB1 ASH2L [activation] EGFR MYO1B [activation] RELA RIOK2 [activation] METTL2A MAPK6 [activation] PAK1 ACVR1 [activation] EPPK1 EGFR [activation] ICAM1 RPS23 [activation] HSPA2 PARP2 [activation] HIST2H2AC BARD1 [activation] SH3KBP1 KATNB1 [activation] ITGA4 EIF2S1 [activation] JUN BATF2 [activation] MAP3K5 PPP3R1 [inhibition] HSP90AA1 GRK4 [activation] NOP2 MCM7 [activation] APP SMAD1 [activation] IRS1 MAPK9 [activation] ANXA2 RPA3 [activation] PTK2B MYD88 [activation] FKBPL RAF1 [activation] MOB4 LATS1 [inhibition] HIST1H2AA EGFR [activation] SRPK1 APEX1 [activation] WNK1 YWHAB [activation] BCL6 SENP7 [activation] AP1M2 PVR [activation] CASP9 CASP10 [activation] S100A1 TP53 [activation] RPA2 PRIM2 [activation] VCAM1 RCC2 [activation] TAGLN2 FTSJ1 [activation] DDX21 GABARAPL2 [activation] OCEL1 SRPK2 [activation] MIF MAP1LC3B [activation] NMI STAT6 [activation] PRNP TMEM237 [activation] SPP1 STAU1 [activation] SFN GAB2 [activation] HEATR1 ITGA4 [activation] APC SFN [activation] RB1 TFDP1 [inhibition] DSG4 GABARAPL2 [activation] BUB1 SHC1 [activation] 页 435 共 454


2016/4/8 19:15

SRBD1 RPA1 [activation] YWHAB ADAM22 [activation] PGR NCOA1 [activation] TPT1 HSPB1 [activation] AXIN2 PLK1 [activation] PRLR PPIA [inhibition] TIMP2 RANBP1 [activation] GADD45A JMJD1C [activation] VRK2 NFATC2 [activation] TRAF6 ERLIN1 [activation] ACTG1 NFKBIB [activation] EXOC3 APP [activation] A2M RHEB [inhibition] WDYHV1 ACTG1 [activation] ARRB2 PPP1R12A [activation] CEP78 HSPB1 [activation] RAB13 RPA1 [activation] PELI3 TRAF6 [activation] JAK2 TSHR [activation] NOTCH1 USP12 [activation] TRAF3 PPP3R1 [activation] CAMKK1 YWHAQ [activation] ABI3 WASF2 [activation] HSPA4 TP53 [activation] CAPN10 EFNB1 [activation] SCAMP5 STX8 [activation] PTPN11 LEPR [activation] HSP90AA1 RPS6KA6 [activation] OSGIN1 AKT1 [activation] SSH1 YWHAZ [activation] NUP62 NUPL1 [activation] HMGB1 PGR [activation] NEDD1 CAPNS1 [activation] STAT3 JUN [activation] MTNR1A GNA13 [activation] GABARAP CDC5L [activation] AKT1 STK11 [activation] QRICH2 SNAI1 [activation;inhibition] TP53 CCNH [activation] ZAP70 ABL1 [activation] GSK3B GBP2 [inhibition] INSIG2 ENO1 [activation] TNIK DPYSL3 [activation] ZFP36 MAP3K4 [activation] CTNNA1 CDH15 [activation] CASP3 ACIN1 [activation] WASF1 LRRK2 [activation] RPA1 KCNAB2 [activation] DOK2 LYN [activation] AMOT INADL [activation] PIK3R1 THRB [activation] CDK1 HSP90AA1 [activation] CAV1 GNAI2 [activation] MAPK8 SMAD2 [activation] HGF SDC1 [activation] CNTN4 BARD1 [activation] CDH7 CDH15 [activation] PARP1 ETS1 [activation] L1CAM CNTN1 [activation] BCL6 ZBTB7A [activation] PXN XPO1 [activation] ASGR2 F8 [activation] COMMD1 ATP7A [activation] SFRP4 PTPRJ [activation] MAB21L3 STAC3 [activation] RALGDS RAPGEF2 [activation] MAPKAPK5 ZNF576 [activation] RPS28 MDM2 [activation] ANAPC7 CDC5L [activation] FAS TNFRSF1A [activation] PTPRU CTNNB1 [activation;inhibition] NXF1 RAB5B [activation] RIOK3 CDC42 [activation] YWHAH WDR20 [activation] ZMYND11 SRPK1 [activation] NXF1 PRKACA [activation] 页 436 共 454


2016/4/8 19:15

AR CASP1 [activation] STAT1 HSP90AB1 [activation] GSTK1 EGFR [activation] GP6 CRKL [activation] NR1H3 ING3 [activation] PTBP3 COL1A1 [activation] TWIST1 HDAC2 [activation] PLXNB3 BTBD3 [activation] VCAM1 GART [activation] FURIN DDX56 [activation] STAT3 RELA [activation] CBL HTR2A [activation] NSMCE4A SRPK1 [activation] CDC25A NXF1 [activation] CHEK2 PLK1 [activation] KCNA4 SRC [activation] KIAA1377 TNFSF11 [activation] MAPKAP1 RICTOR [activation] USF1 PARP1 [activation] ZNF259 CDK5RAP2 [activation] ITGAX FCER2 [activation] OPRD1 GJA4 [activation] STX5 VAPB [activation] CREB3 RAB23 [activation] CASP12 HSPA5 [inhibition] SMARCAL1 RPA1 [activation] PAX6 SUMO1 [activation] PRKCI HSP90AA1 [activation] NEDD1 CRTC3 [activation] TNFRSF1A MYL12A [activation] HDAC1 PRKACA [activation] PHC2 MAPKAPK3 [activation] USP7 PPARG [activation] GRM6 GNAO1 [activation] SGK1 LETM1 [activation] CDK5R1 SET [activation] EGFR CARS2 [activation] PRKACA RELA [activation] ARHGAP1 WAS [activation] PSEN1 FGF13 [activation] TRAP1 HLA-B [activation] ADORA1 GNAI2 [activation;inhibition] PAK2 P4HB [activation] TCF12 MYF6 [activation] PTPN6 NOS1 [activation;inhibition] MYF5 CSNK2A1 [activation] RXRA PPARD [inhibition] EP300 ANXA2 [activation] CD4 CD82 [activation] PPP2R1A CDK4 [inhibition] PRKDC MAPK9 [activation] TTC23 BHLHE40 [activation] TTC23 PNMA5 [inhibition] ICT1 VARS2 [activation] PDIA6 MTNR1B [activation] WASL PFN1 [activation] RGS2 MON1A [activation;inhibition] ST5 SFN [activation] CAV1 AXIN1 [activation] ACTG1 WIPF1 [activation] HSPA2 CDK1 [activation] PARK2 BCL2L1 [activation] YWHAZ MTOR [activation] MAPKAPK5 MAPKAPK2 [activation] EIF2S1 PRKCD [activation] SH3BGRL3 EGFR [activation] OBSL1 RPS6 [activation] CSNK1A1 IKBKB [activation] SOCS3 PIN1 [inhibition] ANAPC5 SMURF1 [inhibition] NFE2L2 KPNA3 [activation] MOS KRT40 [activation] NR3C1 ZNF496 [activation] GRIP2 GRIA2 [activation] PIK3R1 PIK3AP1 [activation] PPP2CA KPNB1 [inhibition] 页 437 共 454


ACTG1 MYC U2AF1 VEGFA EDA YWHAG PGR TRAF6 EIF4E MME EPAS1 KIR2DL1 MKNK2 CCR1 E2F1 TBRG4 CAMK1D RAN RHOF BRK1 TERF1 APP MDM2 CASP2 MET HIPK3 NCOA2 LRP6 FCGR2A FASTKD5 CASC3 PREX1 UBE2I MDM2 YES1 SMARCA5 GPR25 CALM1 SUMO1 POLR2A RAC2 CASP9 IKBKE PTPN1 SMAD2 STK3 PIK3R1 MRPS23 RHEB CBL GNA11 LSR FZR1 MAPK3 PCBP1 YWHAH SELPLG DNAJA1 ARRB2 CDK17 KCTD15 FRAT2 GHR MAPK3 FLT4 STK3 ILK FAS KNG1 NR3C1 GNA12 SIRT1 MARK3 IFNAR1 NRXN1 RECQL5

2016/4/8 19:15

GSN [activation] RBFA [activation] SRPK1 [activation] TNXB [activation] SEC22A [activation] HSPA1A [inhibition] TRIM24 [activation] ERN1 [activation] SMYD2 [inhibition] CMSS1 [activation] STAT5A [activation] PTPN6 [activation;inhibition] ESR1 [activation] TPST1 [activation] CDH1 [activation] EGFR [activation] ASAH1 [activation] SLX4 [activation] NXF1 [activation] NLGN1 [activation] SMAD9 [activation] SMARCB1 [activation] RHOA [activation] RB1 [activation] GLMN [activation] TGFB1I1 [activation] ESR1 [activation] ANTXR2 [activation] ITGA4 [activation] IRAK2 [activation] EIF4A3 [activation] RPTOR [activation] AURKA [activation] ETFA [activation] FASLG [activation] SNW1 [activation] CCDC155 [activation] ATRX [activation] ENO3 [activation] CCNH [activation] AFG3L2 [activation] GZMB [activation] SMC4 [activation] TRPV6 [activation] LAMA5 [activation;inhibition] GBP2 [activation] FOXH1 [inhibition] SMURF1 [inhibition] CREB3 [activation] YWHAZ [activation] PTGIR [activation] SFN [activation] NINL [inhibition] TNFSF11 [activation] ATF2 [activation] HDAC4 [activation] SYK [activation] OSGEP [inhibition] DRD4 [activation] YWHAZ [activation] NOTCH2NL [activation] CDKN2A [inhibition] SKP1 [inhibition] HIF1A [activation] IKBKG [activation] RAF1 [activation] RNF19A [activation] RIPK1 [activation] AGT [activation] POU1F1 [activation] PPP5C [activation] HES1 [activation] FOS [activation] STAT3 [activation] MLLT4 [activation] RAD50 [activation] 页 438 共 454


2016/4/8 19:15

RFC1 MLH1 [activation] STAT3 CCR5 [activation] HNRNPA1 SUFU [activation] SH3KBP1 RPA1 [activation] IRF1 SUMO1 [activation] ADRA2B YWHAZ [activation] HSPA4 MET [inhibition] SYN1 MAPK3 [activation] NFKBIA HSPA1L [activation] CLNK LCP2 [activation] CYTH2 MYD88 [activation] ISG15 FAM120C [activation;inhibition] PPP2R1A PDCD10 [inhibition] SPG20 APPL1 [activation] PRKCA JAK1 [activation] F2 GP1BA [activation] CSNK2A1 ATF2 [activation] EIF1B NUDC [activation] AMOT ACTB [activation] HEMGN SRC [activation] CFL1 RPS6KA1 [activation;inhibition] HIST3H3 MGA [activation] PPP1R15A POU3F3 [inhibition] ENKD1 TRAF2 [activation] LYN FRS2 [activation] PRKCZ C1QBP [activation] TP53 TOE1 [activation] CYCS ESR2 [activation] LRRN4CL SRPK2 [activation] KCTD17 TP53 [activation] NFE2L2 JUND [activation] SETDB1 ERG [activation] ARAP1 SNW1 [activation] OTX1 LCE2D [activation] SIRT3 GRN [activation] GORASP2 DPYSL2 [activation] UPF3A IFITM2 [activation] FOXO1 THRB [activation] PRKDC OBSL1 [activation] ARHGEF12 ARRB2 [activation] TP53 ASF1A [activation] APP GAK [inhibition] EHMT2 CCDC33 [activation] STK4 PIH1D1 [activation] CLEC11A MYC [activation] RTKN2 PACSIN1 [activation] SPI1 GATA3 [inhibition] ANK1 OBSCN [activation] HSP90AB1 SLFN11 [activation] PTPRU GNAI3 [activation;inhibition] SMURF2 EPHA1 [activation] JUN MAP2K7 [activation] MAPK14 YY1AP1 [activation] TGFB1 WFIKKN2 [inhibition] H3F3A MAPK9 [activation] GAL GALR1 [activation] ACTB CDKN2A [activation] SLC1A5 EGFR [activation] TSC22D1 RGS1 [activation;inhibition] SRC DOK4 [activation] SUMO3 SMARCA1 [activation] CAPN5 MLH1 [activation] MYO16 CYFIP1 [inhibition] DIRAS1 APP [activation] HSPB2 HSPB3 [activation] FYN CD2 [activation] DPP4 PTPRC [activation] BAX MAP2K1 [activation] LUC7L2 CDK5RAP2 [activation] ANAPC13 ANAPC16 [activation] MYC XDH [activation] SHC1 DDX5 [activation] TNC EGFR [activation] FAM98B NXF1 [activation] SFRP2 BMPR1A [activation;inhibition] RALGDS RAP1GAP [activation] 页 439 共 454


2016/4/8 19:15

ABI1 GRB10 [activation] ENO2 SUMO4 [activation] HMGB1 TP53 [activation] TRAF2 IL15RA [activation] PLK1 PLK2 [activation] NR4A1 TERF1 [activation] CD38 LCK [activation] P2RX3 P2RX2 [activation] NOTCH1 ERH [activation] TWF2 LYAR [activation] KRT17 APC [inhibition] IGF1R YWHAZ [activation] CALM1 CCND1 [activation] MAPK14 FKBP8 [activation] KCNN2 CALM1 [activation] MTIF2 NFKBIB [activation] WHSC1 PBRM1 [activation] CCL5 WT1 [activation] SRC SP1 [activation] TP53 HSPA1L [activation] PECAM1 JUP [activation] GSN CASP4 [activation] BLK PLCG2 [activation] ATF4 GOLGA8DP [activation] MAP2 JUNB [activation] RELA SIRT6 [activation] FOXO3 H2AFX [inhibition] CSF2 MEOX2 [activation] EIF4A1 SUMO3 [activation] MYC P4HA1 [activation] AURKB CCDC8 [activation] RORC ARNTL2 [inhibition] NCL ITGA4 [activation] YWHAZ PARD3 [activation] IGHA1 IGLC1 [activation] NCAM1 PLCG1 [activation] STAT3 IL6ST [activation] HIST1H1A CCNB1 [activation] IL4 CD53 [activation] FOXRED2 PRKDC [activation] PHLDA3 MCM5 [activation] PLCG2 GAB1 [activation] RELA SMAD4 [activation] CASP4 NOD1 [activation] MLH1 PCNA [activation] STAT5B CRKL [activation] CALM1 ESR2 [activation] PAK1 ARHGEF7 [activation] CAMK2N2 CAMK2B [inhibition] UNG SEZ6L2 [activation] CSNK1E PPP1CA [activation;inhibition] SIT1 SYK [activation] ANK1 NBPF3 [activation] TNFRSF10A TNFRSF10B [activation] EPHA7 EPHA2 [activation] SP1 FHL2 [activation] YAE1D1 GABARAPL2 [activation] GRIN2B PIK3CA [activation] CCDC136 STK11 [activation] DAPK1 LRRK1 [activation] CASP3 CTTN [activation] RPA1 NTPCR [activation] PTCH2 IHH [activation] STK4 STRN4 [activation] PLEKHM1 BID [activation] CD2 EP300 [activation] DOCK8 DOCK7 [activation] FANCA FYN [activation] UNC93B1 NXF1 [activation] SRPK1 MMTAG2 [activation] FOXP3 HIST1H1B [activation] FOS AGTPBP1 [activation] DDX24 GIT1 [activation] CAV3 PDGFRA [activation] EDN1 BAG6 [activation] TRIM38 RIPK1 [activation] 页 440 共 454


2016/4/8 19:15

APP CMTM3 [activation] USP42 RAD50 [activation] RASSF3 VAPB [activation] MYO1C MAP3K3 [activation] TRAF6 MSR1 [activation] OLFM4 C3 [activation] CAMK2B MRPL11 [inhibition] YWHAG KCNK15 [activation] SH3BGR CAPN1 [activation] TRAF6 RANGAP1 [activation] CIAO1 HSPB1 [activation] STAT1 TP53BP1 [activation] VIM PAK2 [activation] FGFR2 STAT3 [activation] PRKCA HIST1H1E [activation] TEX11 CDKN1A [activation;inhibition] WNT4 PTEN [activation;inhibition] KATNA1 LIPE [activation] IGHG1 TGM4 [activation] ABL1 ERBB2 [activation] ZNF106 APC [inhibition] GTPBP2 PRMT5 [activation] BDNF NCAM1 [activation] STX17 CTNNA1 [activation] ANXA7 GNB5 [activation] PTCD3 IFITM2 [activation] TRAF2 ARNT2 [activation] KCNAB2 KCNA2 [activation] CEBPB ATF3 [activation] MAPKAPK3 BUB1 [activation] ATM TFF1 [activation] CXADR AMICA1 [activation] NR3C1 RAD54L2 [activation] PARP1 MYB [activation] SKI NLK [inhibition] PAXIP1 C2orf42 [activation] RGS19 MAPK6 [activation;inhibition] GRIA4 ACTN1 [activation] TJP2 SRPK2 [activation] CCER1 NOTCH2NL [activation] CCDC57 PER1 [inhibition] EGFR PHLDA1 [activation] EXTL3 FYN [activation] F8 VWF [activation] LCP2 WAS [activation] TNFSF10 ACP5 [activation] DLGAP2 GRB2 [activation] PCSK2 IAPP [activation] KAT2B IRF7 [activation] HSPG2 FGF1 [activation] UBE2N F12 [activation] CACNB3 FASLG [inhibition] LRCH2 RASSF10 [inhibition] INSIG2 DSP [activation] GAK CREBBP [activation] ATM STK11 [activation] SOX3 PAX6 [activation] KAT2B CEBPB [activation] LPL PLK1 [activation] PPARG GADD45B [activation] CSMD2 MYC [activation] HSPA8 PPP1CA [inhibition] EIF4A1 MAPK13 [activation] MYC LCN12 [activation] BEND3 RIOK2 [activation] CCND1 KLK9 [activation] TNFSF11 MAPK1 [activation] TNIK RANBP1 [activation] ARHGEF5 EGFR [activation] VCL ABI2 [activation] RPL12 ICAM1 [activation] NCF1 CAV1 [activation] NEIL2 EP300 [activation] LHX2 MSX1 [activation] LLGL2 PRKCI [activation] ATP13A2 VAMP2 [activation] 页 441 共 454


ATP13A2 SPHK1 PLK1 SMAD1 LTA KAT2A RAD9A HNRNPL NFE2 PML PDGFB IRS1 BHLHE40 SRP54 BARD1 VCAM1 CRK MMP9 RASA1 NDRG1 TP53 NCF1 PLXNA1 RPL5 EGFR UBQLN1 SMAD3 QRICH2 CTNNB1 PADI1 EP300 RAC1 ETS1 PRKRA TP53 CDH2 SUMO1 EEA1 ESR1 OSM TNFSF10 SMAD3 NXF1 STAT3 HNF4A HSPA4 RADIL AGAP7 CDKN3 H1F0 RB1 DAPP1 NR4A1 GNAQ IGHG1 SMURF1 SLX1A PTPRC EIF2AK2 PAXIP1 PECAM1 GMCL1 CCDC88C MLST8 TCOF1 OGT GRB2 AXIN1 VAPB ELAVL1 RAF1 ENAH TYK2 SRPK2 NDUFB10 PASK

2016/4/8 19:15

ACKR3 [activation] TRAF6 [activation] SRPX [activation] EP300 [activation] TUBA4A [activation] ESR1 [activation] CHEK2 [activation] ITGA4 [activation] YAP1 [activation] RBL2 [inhibition] PDAP1 [activation] PRKCZ [activation] NFIL3 [activation] STK4 [activation] KRI1 [activation] CCL17 [activation] FLNC [activation] RECK [inhibition] SYN1 [activation] HSD17B4 [activation] MVP [activation] GNAI2 [activation] FBXO6 [activation] SPP1 [activation] YWHAQ [activation] CCL7 [activation] RUNX1 [activation] TSSC1 [activation] PSEN2 [activation] TP53 [activation] ESR2 [activation] IL1RAP [activation] ELP2 [activation] IGF2BP1 [activation] PTCD3 [activation] PTPRG [activation] TRAF6 [activation] ERBB2 [activation] ISL1 [activation] COL4A6 [activation] SOCS3 [activation;inhibition] CREBBP [activation] DCTPP1 [activation] BICD1 [activation] ESR1 [activation] BCR [activation] CCNH [activation] HSPB1 [activation] CDC25A [activation] CCNE1 [activation] TP73 [activation;inhibition] MAP4K1 [activation] SLC25A4 [inhibition] BTK [activation] IGLC1 [activation] ARHGAP15 [inhibition] CALM1 [activation] GANAB [activation] EGFR [activation] KMT2D [activation] ITGB3 [activation] STK3 [activation] DVL1 [activation] ULK1 [inhibition] SRPK2 [activation] THAP3 [activation] DRD3 [activation] WWTR1 [activation] INSIG1 [activation] SERPINE2 [inhibition] PRKG1 [activation] ABI3 [activation] PTAFR [activation] DAW1 [activation] HTR2A [activation] PKIA [inhibition] 页 442 共 454


YWHAB RAF1 AR COL4A5 MAP2K4 CGA TTC39C NR3C1 DSG1 SMAD4 CABIN1 ACIN1 MCM6 SRC PXN LYPLA1 NUDC ZAK FADD PRKACA RIPK1 SRC SRC PDE6G CMYA5 KCNA5 IFIT5 KLHDC1 TPX2 MAGT1 YWHAB MAPK6 SOCS1 TGFB1 DLG4 ARRB1 CBLB ABI1 SNAP25 PPP2R3A ATR MAPK9 PTPN11 HRAS ICT1 PIK3R1 ARHGEF7 HSPB3 LAT RCVRN NUCB2 CD79A TUBB4A YWHAB CUL1 BMPR2 TP53 NTS BCL2L1 DNAJA3 PTK2B TP53 KTN1 FANCA TRAF3 CDKN2D OGDH FYN DNM2 TLE1 MAPK3 RELA NSUN2 HNF4A APP CSNK1G2

2016/4/8 19:15

EGFR [activation] MYC [activation] RASA1 [activation] ANXA7 [activation] MAP3K10 [activation] PTN [activation] NXF1 [activation] OSGEP [activation] PPP2R2A [activation] PRKAR1B [activation;inhibition] PPP3CB [inhibition] LRRK2 [activation] HLA-B [activation] ABI1 [activation] ABL1 [activation] ITGA4 [activation] PEX7 [activation] CCDC69 [activation] LRRK2 [activation] CAD [activation;inhibition] PIDD [activation] KCND3 [activation] CCNA2 [activation] GNAO1 [activation;inhibition] SIRT1 [activation] UBE2I [activation] SRPK2 [activation] NUDC [activation] GRB2 [activation] NXF1 [activation] ALS2 [activation] EIF2S3 [activation] TRIM8 [inhibition] FSTL1 [activation] FZD1 [activation] MAPK3 [activation] NCK2 [inhibition] EPS8L2 [activation] ITSN1 [activation] EGFR [activation] HSP90AA1 [activation] CASP3 [activation] PLCG1 [activation] IKZF3 [activation] PARS2 [activation] MST1R [activation] MCM7 [activation] TCAP [inhibition] SPRY1 [inhibition] GRK6 [inhibition] CASP6 [activation] LCK [activation] TRAF6 [activation] PAK4 [activation] EIF4A1 [activation] CES3 [activation] SMAD7 [activation] SORT1 [activation] VDAC1 [activation] JAK2 [inhibition] ZAP70 [activation] CFLAR [activation] RAC1 [activation] CDK1 [activation] IL1RAP [activation] C1orf94 [inhibition] MDM2 [activation] KDR [activation] AHI1 [activation] ATF2 [activation] DCC [activation] BTK [activation] ITGA4 [activation] SMAD4 [activation] STK17B [activation] RUNDC3B [inhibition] 页 443 共 454


2016/4/8 19:15

FZD7 MAGI3 [activation] MYC PLEKHH1 [activation] ATF2 CTNNB1 [activation] YWHAG PRKCQ [activation] VWF RAC1 [activation] SF3B14 VCAM1 [activation] ITPR1 CDK1 [inhibition] FAS RAP1A [activation] CHST10 HSF1 [activation] HIST3H3 TRIM28 [activation] WAS HCLS1 [activation] FBP2 SRC [activation] SETD1A EP300 [activation] NME1 TIAM1 [activation] PLK1 SPAG9 [inhibition] DLL4 NOTCH4 [activation] PLG TFPI2 [inhibition] HIF1AN PPP1R12A [activation] GRB2 ASB16 [activation] ANXA2 MYC [activation] PTK2B SOCS2 [activation] RSRC1 ACTR3B [activation] CHUK PRKDC [activation] HIST3H3 APLF [activation] GRIA3 GRIA2 [activation] VCAM1 MCM4 [activation] PRKCA DDX5 [activation] MYC DDX17 [activation] IGF1R SOCS3 [inhibition] RIPK1 TAX1BP1 [inhibition] ARFIP2 ARF6 [activation] KIT RASA1 [activation] BORA AURKA [activation] BCAR1 YWHAH [activation] APP TSLP [activation] ARF3 MAPK13 [activation] SCAMP1 NXF1 [activation] RPS6KB1 HSP90AB1 [activation] NUP62 CCDC150 [activation] PTTG1 DNAJA1 [inhibition] ADCY2 GNAS [activation] RASA1 ATF7 [activation] RNF135 DDX58 [inhibition] EGFR ALCAM [activation] BTRC KDR [activation] RB1 USP7 [inhibition] TICAM2 IRAK3 [inhibition] GRB2 SMARCD2 [activation] CCNE1 CREBBP [activation] CAPNS1 CDK4 [activation] DOK1 NCK1 [activation] KPNA1 RANBP2 [activation] TROVE2 LRRK2 [activation] FAM47B LRRK2 [activation] SHC3 APP [activation] WNK1 TSC22D1 [activation] ATF4 NFE2L2 [activation] DDX54 APP [activation] RASSF10 SERPINB3 [inhibition] MAPRE2 CDK4 [inhibition] ADAM12 GRB2 [activation] ELK1 CREBBP [activation] RASA1 ZNF579 [activation] PARD6G HSPA4 [activation] TGFB1I1 NR3C1 [activation] EXOC1 EXOC4 [activation] CCDC8 RPA1 [activation] ARNTL RXRA [inhibition] HOXC10 YWHAG [activation] CFTR DCLK1 [activation] EHMT2 HIST1H1A [activation] VAPA OPRM1 [activation] MAP3K8 CHUK [activation] HSP90AB1 PRKCI [activation] ATF2 TPI1 [activation] EP300 POU3F2 [activation] 页 444 共 454


2016/4/8 19:15

EZH2 RELA [activation] ATP1A1 ADRB2 [activation] UBE2K DDX58 [activation] TBK1 CCDC8 [inhibition] POLR2E SRPK1 [activation] IRAK2 HRAS [activation] CBLB FLT3 [inhibition] EP300 FOXP3 [activation] BMPR2 PYCARD [activation] NFATC2 CREBBP [activation] TIMP2 APC2 [activation] ASB14 SLC25A6 [activation] RHOA HLA-B [activation] TPP1 POT1 [activation] HSPA4L TRAF6 [activation] SMAD1 TTF1 [activation] PPIA GRB2 [activation] APP CNDP1 [activation] SRPK1 C6orf201 [activation] BCL2L1 UBR1 [activation] PAX6 DYNLL1 [activation] INSR FRS2 [activation] MYLPF EZH2 [activation] HNRNPL HIST3H3 [activation] SRF CASP7 [activation] CUL1 GLMN [activation] MRPS25 TP53 [activation] PCSK6 RXRB [inhibition] RXRA CTNNB1 [inhibition] CASP3 EIF2AK2 [activation] MET RASA1 [activation] BTRC IFNAR1 [activation] TIMM50 ILK [activation] PPP2R1A PPP2R3B [activation] IKBKB PRKCD [activation] HTT PRNP [activation] NCL NBN [activation] RHOJ ACVR1 [activation] EGFR LSR [activation] PPP2CA RBL2 [inhibition] TNF IKBKG [activation] ABL1 DLGAP3 [activation] DVL3 NKD1 [activation] MAP1LC3C ULK1 [inhibition] BAG6 FAS [inhibition] IGHA1 CDK2AP1 [activation] CASP7 CRYAB [activation] EFNA3 PRSS23 [activation] PPP2R1A MAP3K3 [activation] BIRC2 CDC42 [activation;inhibition] GNPTAB APP [activation] SRC CEACAM1 [activation] CHGB SLC25A6 [activation] MYC EFNB1 [activation] LCN2 MMP2 [inhibition] MAP2K3 SMAD7 [activation] CCL21 CXCL13 [activation] PGAM5 STRN [inhibition] ARFGEF2 ARFGEF1 [activation] TTC23L EGLN3 [activation] PRIM1 EGFR [activation] EGFR TRPV1 [activation] HOMER3 PAX6 [activation] ROCK1 CASP3 [activation] GNL3 PPP2R5A [activation] GRB2 ACTB [activation] GATA6 CDK9 [activation] YWHAG MARK3 [activation] FSCN1 TRAF6 [activation] APP MAST1 [activation] NKIRAS1 XRCC2 [activation] SP100 LRRK2 [activation] CD3D CD8B [activation] ITCH SGK3 [activation] DAB1 FAM168A [activation] ZDHHC17 PDPK1 [activation] 页 445 共 454


2016/4/8 19:15

FGFR3 POLA2 [activation] MIIP PPP1CA [activation;inhibition] PIK3CA SLC9A3R1 [activation] CD40 PIK3R1 [activation] CSRP1 GRB2 [activation] PIK3R2 SOCS1 [activation] MET SYK [activation;inhibition] EVL BAIAP2 [activation] MYB BTRC [activation] ZFYVE9 SCYL2 [activation] TP53 RAE1 [activation] EIF2S3 ELAVL1 [activation] CDC5L POLD1 [activation] IRF2 HCFC2 [activation] HAP1 CDK5RAP2 [activation] FGR FASLG [activation] STK4 ANXA1 [activation] SMAD1 NOTCH2 [activation] HTR1A RHOA [activation] TNFRSF1A PRKCD [activation] H3F3A LRRK2 [activation] IKBKE MAD2L1 [inhibition] BMX PAK1 [activation] SMAD2 MAP2K1 [activation] MYOM1 DYSF [activation] CTNNA1 APP [activation] BID CAV1 [activation] SMAD2 TSC2 [activation;inhibition] MAPK1 HSF4 [inhibition] IRF2 STAT1 [activation] GRK1 SNCG [inhibition] TMEM66 STIM1 [activation] SMARCB1 BCL2L11 [activation] FOS ATF7 [activation] PPP2R2B DSG1 [activation] YWHAG FAM53C [activation] ROBO4 RXRA [inhibition] TGFBR2 TGFBRAP1 [activation] GRB2 GNS [activation] KRT40 RAC1 [activation] ARHGEF15 EPHA4 [activation] SORT1 NTRK1 [activation] CDC23 SSX2IP [activation] NRD1 HBEGF [activation] YWHAE BCR [activation] CACNA1D FGFR2 [activation] RBM33 GRB2 [activation] STAM2 EGFR [activation] SHC1 CDC5L [activation] FGF10 POMC [activation] MAPK8 PIAS2 [activation] SENP1 KCNK1 [activation] MAPK14 KRT18 [activation] NPY NPY2R [activation] NUP153 NUP62 [activation] THRB CAMK2B [activation] PES1 VCAM1 [activation] PRRG2 YAP1 [activation] ATR PPP2R2A [activation] LGI1 ADAM22 [activation] SPTBN1 CAPN1 [activation] CAPRIN1 RPA3 [activation] EFNA4 MOV10 [activation] ESR1 HIF1A [activation] PRKAR2B PRKACB [activation] GCN1L1 TRAF6 [activation] ECT2 PIK3R1 [activation] APH1B PSENEN [activation] SEC23B UGT1A1 [activation] ACTG1 UBL4A [activation] RASAL2 YWHAG [activation] PTPN11 PTPN6 [activation;inhibition] CREB1 UBE2I [activation] C2orf73 HSPB1 [activation] NXF1 MSL1 [activation] IL2RB LYN [activation;inhibition] 页 446 共 454


ITGB2 FCER2 KRT16 GRB2 SMC3 EGFR ESR2 MRPS27 EIF4A2 HSPB1 VAV1 SOCS1 PAK2 CTTN SRF ATF6 ERBB4 ERBB3 TAF1B UBTF CSNK2A1 L1CAM ANXA5 COL10A1 UBA5 SARS YWHAG SRPK1 BLM ERCC6L RHOJ BMPR1B PRPSAP2 APP NFATC1 FOXP3 ANAPC4 SH3KBP1 PKIG KPTN APP NOTCH1 SRPK2 CACNG2 TFDP2 E2F1 LRRK2 DFFB APP KCNIP4 NFKB1 ESR1 CREB3 SCP2 CD164 CXCR4 PA2G4 E2F1 CREBBP WT1 EPB41L3 CNTNAP2 HIF1A VHL ARPC2 ARPC4 STK4 TAOK1 ITGA4 CAPNS1 BCL2L11 VDAC1 FAAP20 FANCD2 CDKN2C SCGB2A2 THADA USHBP1 ID1 MYF5 KCNE1 PRKCA SRI SMAD2 ACACA NEDD8 CCDC8 SLC25A6 NRIP1 KAT2B FCGR3A CD4 RHOJ BLZF1 PAK6 CDK1 ACAP1 GRB2 GEM APOH PDPK1 PNO1 LIMS1 STK11 SMURF1 PRKAR1A HSPA2 LGR4 CDC42BPA MARK3 YWHAB PML EGFR MAPKAPK2 GZMA NDUFS3 THOP1 MPP6 CHEK1 MCPH1 CCL7 ACKR4 PRKAB2 ULK1 THBS1 SCARB2 AR SH2D1B WHSC1L1 FGFR4 EEF2K PRKACA TSC1 ACTA2 GAK LRRK2 FOS XBP1 IL13RA2 ERBB2 ESRRB NCOA3 HMGB1 VCAM1 DNAJA2 FBXO6 KIAA0930 ENO2 MAP4

2016/4/8 19:15

[activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] [activation] [activation] [inhibition] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [inhibition] [activation] TAF1 [activation] [activation] [activation] CREB1 [activation] [activation] [activation] [activation;inhibition] [activation] [inhibition] [activation] [activation] [activation] [activation] [activation;inhibition] [activation] [activation] [activation] [activation] [activation] [inhibition] SFN [activation] [activation] 页 447 共 454


2016/4/8 19:15

ANAPC16 CDC23 [activation] CCDC33 RAD54B [activation] GRB2 TMOD3 [activation] CCL8 DARC [activation] GRB2 TRIM39 [activation] ICT1 MRPL55 [activation] TBX21 CREBBP [activation] KDR ATR [activation] GLMN CDC37L1 [activation] PMAIP1 PPBP [activation] RAC1 NCKAP1 [activation] GPN1 GPN3 [activation] BCL3 FOS [activation] SUV39H1 MTO1 [activation] NKX2-3 SRF [activation] NKX2-1 CRK [activation] RNF8 NBN [activation] ERBB2 OSMR [activation] SEZ6L2 FOXA1 [activation] ACTB CARM1 [activation] MAPK3 RAB4A [activation] CASP3 CDKN1A [activation] NKX2-1 WWTR1 [activation] ARAF BRAF [activation] F12 GP1BA [activation] PAXIP1 PPHLN1 [activation] TERF1 SH3GL3 [activation] JUN NRIP1 [activation] GOLGA2 CDK18 [activation] DCN COL4A4 [activation] CAPN1 GPT [activation] GTF3C2 RPTOR [activation;inhibition] EP300 PRKAA1 [activation] CALD1 RPA3 [activation] NDC80 MAD2L1 [inhibition] RAD51 RPA3 [activation] GNAS CHEK2 [activation] MLH1 LEF1 [activation] GRB2 HIBCH [activation] PRMT1 TNFRSF14 [activation] CEP170P1 CCDC146 [activation] DUSP22 MAP2K4 [activation] SPP1 BRD3 [activation] KDM6A AR [activation] CDH1 HEMGN [activation] MS4A2 AKT1 [activation] EIF2B5 CSNK2A1 [activation] GABARAPL2 TIAL1 [activation] PIK3C3 HSP90AA1 [activation] ABI3 EVL [activation] TNFRSF1B GBF1 [activation] HNF4A ZNHIT3 [activation] GABARAPL2 NUP88 [activation] CDC14B SIRT2 [activation] DNAJB1 SPP1 [activation] GBF1 IVNS1ABP [inhibition] KCTD12 HLA-B [activation] STK4 FBXW11 [activation] SHC1 CRK [activation] NUP62 KPNA1 [activation] YWHAQ LRRK2 [activation] HDAC4 YWHAG [activation] HGS PAK1 [activation] MYC ARMC6 [activation] CACNG2 INADL [activation] SPRR3 IVL [activation] CSNK2A1 MAPT [activation] CEACAM1 ANXA2 [activation] CCDC8 MAPK11 [activation] GAB1 BLK [activation] NUP188 VCAM1 [activation] TCL1A EP300 [activation] CDK1 SNW1 [activation] RPL23 LRRK2 [activation] ANXA5 KDR [activation] SYK UBASH3B [activation] 页 448 共 454


2016/4/8 19:15

ESR1 PAK6 [activation] MEOX2 VIP [activation] EP300 MCM2 [activation] POLA2 RBM23 [activation] EDN3 CTSE [activation] DOK1 EGFR [activation] DLL1 CNKSR3 [activation] HSP90AA1 MAP3K6 [activation] CCDC8 LUC7L [activation] ANXA2 VCAM1 [activation] RICTOR MTOR [activation] RAD21 CCAR2 [inhibition] NOS1 ADRB2 [activation] PARP12 BCL6 [activation] RRAGB RRAGC [activation] PFDN1 SKP2 [inhibition] H2AFX HIST3H3 [activation] MAPK13 TFG [activation] SRC DOCK8 [activation] TSC1 CD63 [inhibition] F11 TFPI2 [inhibition] BRCA1 E2F1 [activation] APC AXIN2 [inhibition] KPNA2 CASP2 [activation] TP63 MYL12A [activation] CSNK1A1 MAPT [activation] CASC3 PTPN1 [activation] NCF1 MAPK9 [activation] SKP2 SPDYA [inhibition] GNAI3 SOX30 [activation;inhibition] HNRNPUL1 ATM [activation] TLR2 EGFR [activation] STAT1 TNFRSF1B [activation] ESR1 PPARG [activation] ORC4 MLH1 [activation] HSP90AA1 FOXP2 [activation] FRMPD4 STK36 [activation] TP53 DNAJB1 [inhibition] HSPA6 CISH [inhibition] ARHGAP33 RAC1 [activation] ZMYND19 ENOX1 [activation] CALCA ECE1 [activation] ECSIT EXOC6 [activation] LYN FOLR1 [activation] CTSC FBXO6 [activation] POLD1 ERCC6 [activation] CTNNA1 SFRP4 [activation] STK4 HSPA1L [activation] PIK3R1 FANCA [activation] SRC FCGR2C [activation] MAPK1 PLK3 [activation] LARP1 YWHAB [activation] SAMD4A YWHAG [activation] THRB NCOA1 [activation] HSP90AB1 ARMC5 [activation] MAPRE1 HLA-B [activation] EIF4A3 JAK1 [activation] PRKACA HSP90AB1 [activation] PLXNB1 RND3 [activation] SKP2 WEE1 [inhibition] TGFBR2 TRAF6 [activation] PTPN11 PILRA [activation] ATG5 RHPN2 [activation] PAXIP1 SNRNP70 [activation] PRKCE ACTA1 [activation] CDKN2C ANGPTL4 [inhibition] STAT1 SPTBN1 [activation] MAP3K7 EIF2AK2 [activation] TP53 MRPS14 [activation] POP4 MYC [activation] CASP3 CASP4 [activation] TRDMT1 STX1A [activation] MAP2K1 BUB1 [activation] LPAR1 ARHGEF12 [activation] TGFBR1 SKI [inhibition] STRA13 FANCC [activation] 页 449 共 454


2016/4/8 19:15

RUNX1 CDK1 [activation] KMT2A E2F4 [activation] PRKD2 XPO1 [activation] CHRD SPRY2 [inhibition] YWHAG EIF4A3 [activation] CTNNB1 MDM2 [activation] GAPVD1 NXF1 [activation] SMURF1 TNNT1 [inhibition] RPS17 CACNA1A [activation] DAG1 AGR3 [activation] GALR2 NPY1R [activation] CDH5 KDR [activation] SDC1 PECAM1 [activation] L3MBTL1 TP53 [activation] MZT2B TP53 [activation] ICAM1 HIST1H1E [activation] MYC HDAC3 [activation] H2AFX SUPT5H [activation] EPB41L3 CDC5L [activation] BUB1B COMMD4 [inhibition] KIF11 SNW1 [activation] ST3GAL6 APP [activation] KDM1A ISL1 [activation] TRAF3 NFKB2 [activation] TP53 YWHAG [activation] APPL1 LUC7L [activation] CDK7 CCNH [activation] SFRP4 CDKN2A [inhibition] PILRB PTPN11 [activation] RET SOS1 [activation;inhibition] SMAD2 CSNK1D [activation] PLG F10 [activation] AURKA PML [activation] NCOA1 CXADR [activation] FYN IL3RA [activation] JAK1 CCR1 [activation] NCR2 TYROBP [activation] MYH14 GRB2 [activation] SHC1 VARS [activation] PTPRA PTPRF [activation;inhibition] NEU3 GRB2 [activation] ICT1 KIAA0391 [activation] PTS ATM [activation] NXF1 TBC1D16 [activation] EXOC8 WASH1 [activation] STX5 STX17 [activation] STAP2 PTK6 [activation] CD5 PIK3R1 [activation] NOP10 DKC1 [activation] MAVS BIRC3 [activation] ZAP70 SLA [activation] SSBP4 ISL1 [activation] UNC119 EIF2S2 [activation] HIST1H2BB DYRK1A [activation] EGR2 RIMKLB [activation] GMFB PRKCA [activation] IGF1R MDM2 [activation] NBPF14 MYB [activation] MYC TRAP1 [activation] ZC3HC1 TNFSF11 [activation] VAV1 ARHGDIB [activation] VCL ARPC2 [activation] ESR1 PSIP1 [activation] TH YWHAB [activation] IDH2 MDM2 [activation] IKBKE MIF [activation] RELA HSPA8 [activation] BAG3 BCL2L11 [activation] PPP2R4 CAV1 [activation] KAT2A PRKDC [activation] POLD1 GABARAPL2 [activation] C17orf59 MOS [activation] GRB2 RPS16 [activation] RAC1 HMHA1 [activation] POLD2 EP300 [activation] UBE2I EP300 [activation] 页 450 共 454


2016/4/8 19:15

SUMO1 CEBPB [activation] VCL TEKT1 [activation] C1QC TFAP2A [activation] ADRB2 GRIA3 [activation] PLD1 CAV1 [activation] TCAP ADPGK [inhibition] CD72 GRB2 [activation] TNKS POT1 [activation] PPP1R15A PPP1CA [inhibition] ICT1 MRPL24 [activation] GH1 MAPRE1 [activation] UTP15 MYC [activation] GRB2 MATR3 [activation] ITGA4 CAPZB [activation] DNAJA3 NFKB2 [inhibition] MAGEA3 DNM1L [activation] YWHAZ PRKCE [activation] FGF4 NRP1 [activation] RNF32 MAST1 [activation] KDR YES1 [activation] RUNX2 ETS1 [activation] ATG7 PIK3C2A [activation] HSP90AA1 SRC [activation] ATF2 ITGB4 [activation] IGKV1-5 ATG5 [activation] TXLNA STX4 [activation] GXYLT1 HLA-B [activation] FASLG GRB2 [activation] CD81 HNRNPA2B1 [activation] PRKCZ IL4R [activation] APP F12 [activation] EGFR MAP2K1 [activation] PPP2R2A EIF4EBP1 [inhibition] VASP APBB1 [activation] PTEN CRKL [activation] CDC25C YWHAG [activation] B3GNTL1 MPP3 [activation] ETV1 MAPK8 [activation] RPS6KA5 BAD [activation] PEBP1 FTSJ1 [inhibition] RIPK1 LTA [activation] CRMP1 ANXA7 [activation] MAPK3 PTPN5 [inhibition] ATF2 YWHAZ [activation] PAK2 SNX33 [activation] DMWD FTSJ1 [activation] HIST1H2BB HIST1H3A [activation] SERPIND1 APP [inhibition] NCF1 TGFB1I1 [activation] BARD1 MCM6 [activation] GRAP2 FASLG [activation] SIRT1 CTTN [activation] SLIT2 GPC1 [activation] STX6 PTPN9 [activation] CBL FLT1 [activation] DPYSL5 DPYSL4 [activation;inhibition] TEC VAV1 [activation] MAP2K1 SUMO1 [activation] LRCH4 NOTCH2NL [activation] VCAM1 PYCR2 [activation] KIF11 CDC5L [activation] HSD17B4 CDK7 [activation] PPBP PLEKHJ1 [activation] MAPK14 SRPK1 [activation] COL4A3BP CSNK1G2 [activation] GUSBP1 FGFR3 [activation] MECOM SMAD4 [activation] FSCN1 SGK1 [activation] PECAM1 PTPN11 [activation] YES1 FAS [inhibition] RFX6 PLEKHN1 [activation] YES1 CD2AP [inhibition] KNG1 VTN [inhibition] NUDCD3 CXorf57 [activation] GRB2 NEK8 [activation] DDX5 GABARAPL2 [activation] 页 451 共 454


2016/4/8 19:15

LRRK2 EEF1A2 [activation] PRKRA TIRAP [activation] TP53RK INADL [activation] SRPK2 SUPT16H [activation] PRKCB GJA1 [inhibition] CCDC22 ACTG1 [activation] ISL1 COPS5 [activation] LARP1 YWHAG [activation] OSTF1 FASLG [inhibition] GRB10 GRB2 [activation] SRPK1 FAM76B [activation] APP TBCK [activation] NCF1 ACTG1 [activation] RAC1 GRN [activation] MCC SFRP4 [activation] KCNA3 CAV1 [activation] ERBB2IP ABR [inhibition] AMBRA1 NUDC [activation] AP2S1 NUMB [activation] HDAC4 ATF2 [activation] DAB1 RHOXF2 [activation] ARHGAP17 NXF1 [activation] PGAM5 MAP3K5 [inhibition] FYN WNK2 [activation] ARHGEF7 EGFR [activation] PCBD2 STAT3 [activation] CMTM3 MAPK1 [activation] DOK1 TEC [activation] MMP8 UMOD [activation] ESRRA NXF1 [activation] CTNNB1 APC2 [activation] COL17A1 CTNND1 [activation] ESR1 BUD13 [activation] LRRK1 LRRK2 [activation] RHOA BAIAP2 [activation] ITGAV TGFB1 [activation] TRAF3 TNFRSF18 [activation] GTF2A2 TBPL1 [activation] NXF1 DSN1 [activation] USP7 CLSPN [activation] APP MAPT [activation] GRB2 RAPSN [activation] RELA REV1 [activation] STX3 SYTL4 [activation] SPERT DUSP14 [inhibition] PMAIP1 BCL2L11 [activation] WT1 AREG [activation] SRPK1 SLAIN2 [activation] PPP1CA SFRP1 [activation;inhibition] PRKG1 HDAC1 [inhibition] BCL2L1 IRS1 [activation] ADRBK1 MDM2 [activation] RUNX1 CBFA2T2 [activation] MAPK1 FCGR2B [activation] RAD1 RHNO1 [activation] ITGB1 ENO1 [activation] CREBBP SOX9 [activation] BLK BCL2 [activation] SRPK3 CCDC86 [activation] HSP90AB1 MAP3K7 [activation] YWHAZ MAPT [activation] CHL1 E2F1 [activation] PDZD11 SFN [activation] MARS ITGA4 [activation] IGHG1 TRAF1 [activation] STAB2 MAPK8 [activation] SGTA HLA-B [activation] SUMO1 EGR1 [activation] TNFRSF13C TRAF2 [activation] C16orf74 PPP3CA [activation] CDC42 ARHGAP10 [activation] PTPRE MAPK1 [activation;inhibition] RHOT2 ZFYVE9 [activation] ACTG1 CCDC8 [activation] JUN MYC [activation] TGFBR1 RHOG [activation] 页 452 共 454


2016/4/8 19:15

CTNNB1 USP9X [activation] MECOM SUV39H1 [activation] FYN PRKCZ [activation] GAL GALR2 [activation] VSIG4 C3 [activation] STK11 HSP90AA1 [activation] RICTOR RPL26 [activation] LSM2 RALA [activation] CALM1 SLC9A1 [activation] DHX9 TRAF6 [activation] PICK1 EPHB2 [activation] ITGA4 HIST1H2BL [activation] F2R PROCR [activation] HDAC1 STAT1 [activation] AMIGO1 AMIGO3 [activation] FKBP1A RYR1 [inhibition] CD74 MIF [activation] ANGPTL2 LILRB2 [activation] PTPN12 BCAR1 [activation] YES1 OGT [activation] LRRK2 MATK [activation] OBSL1 UBTF [activation] FES DPYSL5 [activation] GAP43 PLCD1 [activation] EGFR MAP3K3 [activation] DDX18 VCAM1 [activation] PPARGC1A NRIP1 [activation] NAPA GOSR1 [activation] PLK1 CTNNB1 [activation] BARD1 POMZP3 [activation] EPRS ETS1 [activation] EPB41L3 YWHAE [activation] WIZ RICTOR [activation] EIF4EBP3 AURKB [activation] FPR1 MAPK13 [activation] VAPA ZFYVE27 [activation] NDP APP [activation] RIT1 IFRD1 [activation] RGS3 MAPK12 [activation;inhibition] DBNL EIF2AK2 [inhibition] CDK6 ABI2 [activation] SRRM1 SRPK1 [activation] CHUK AURKA [activation] APC TRIM28 [inhibition] CARM1 CTNNB1 [activation] XPO1 STAT1 [activation] PPP2R1B PPP2R1A [inhibition] STK38 EIF4A3 [activation] SKIL CPNE2 [activation] ATP1B3 BARD1 [activation] SLC25A4 BCL2L13 [inhibition] SUMO3 EP300 [activation] RAF1 SH3KBP1 [activation] STRN3 CTNNB1 [activation] CDKN1A MCM7 [activation] HLA-B PDIA4 [activation] CRY2 PER1 [inhibition] SCARB1 PRMT2 [activation] RAC1 AKT1 [activation] POU2F2 RXRA [inhibition] TAB2 PPP6C [activation] CALM1 MYF6 [activation] CCDC85A PFDN1 [inhibition] HSPB1 SLX4 [activation] IGHMBP2 NAA38 [activation] FBXL5 CUL1 [inhibition] NXF1 NXF2 [activation] USHBP1 NGFRAP1 [activation] MAPK8 MAP3K2 [activation] TWIST1 ZIC3 [activation] ENTPD2 STX7 [activation] NXT1 XPO1 [activation] ANP32B DCC [activation] SET PIK3CG [activation] YWHAZ ITGB2 [activation] CCHCR1 NME7 [activation] 页 453 共 454

Interactome-wide predictions 34429 34430 34431 34432 34433 34434 34435 34436 34437 34438 34439 34440 34441 34442 34443 34444 34445 34446 34447 34448 34449 34450 34451 34452 34453 34454

RPTOR G3BP1 PRKDC HMGB2 ACTG1 CYBB STAT3 AMBP CCS YWHAG TRIB3 BMPR2 LIMS1 TRIO LYPLA1 VCAM1 SIK1 VAPA JUND FOSL1 CTTN KCNA2 TRMT11 TP53 CYBA RAC1 CDC5L RPA3 METAP2 MAPK1 NR3C1 ONECUT1 HSP90AB1 APP REG1A CXCR2 GNA14 MAPT MARCH7 SREK1 SRPK2 SRC APOL5 SH2D1B ERBB2 ARRB1 EGFR RAD50 PASK

2016/4/8 19:15

[activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] FOXP2 [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation] [activation]

页 454 共 454

Multi-label 2 Ð¸ -regularized logistic regression for ...

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