Pspice modeling and simulation for design of formaldehyde biosensor ...

Ministère de l’Enseignement Supérieur et de la Recherche Scientifique Université des Sciences et de la Technologie d’Oran Mohamed Boudiaf Laboratoire des Microsystèmes et Systèmes Embarqués (LMSE) -----------------------------------------------------------------------------------------------------------------

Pspice modeling and simulation for design of formaldehyde biosensor readout circuit L. Guerandi(a), N. Boughanmi (a),Ben Ali (b) , A. Errachid(c) ,N. Jaffrezic Renault(c (a) University of Sciences and Technology, Algeria.

LMSE laboratory Electronic departement , BP 1505 El-M’Nouar Oran Algeria . (b) Higher Institute of Applied Sciences and Technology of Sousse, University of Sousse, Tunisia (c)

Laboratoire de Sciences Analytiques, UMR 5180, Université Claude Bernard Lyon 1, France

1- Introduction  Predective macromodel PSPICE based experimental Biosensors Data C(V) measurements.  The Electrical characteristics of BioFET simulated in CMOS 0.35µm Technology  Design and simulation of Circuit BioFET-OTA Based Low-pass filter

BioFET Macromdel PSPICE Level 7 CMOS 0.35µm Based biosensors EOS CV Measurement

Simulated Current Voltage I(V) Characteristics. • Isotherme point . • Thershold voltage • Transcanductance • Input and output curves

Electronic Circuit Readout Operational Transcanductance Amplifier (OTA) low pass filter . 1

2- BioFET • Formaldehyde (CH2O) is a major pollutant in the indoor environment , classified as cancerogen by Agency for research on Cancer (IARC).

Source M.J Schoning and al Analyst, 2002, 127, 1137–1151 1139

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 OrCAD PSpice software facilitates the design and testing of circuitry before the costly fabrication

pX=- log[XZ+ ] =

∗ Vth(isfet)

qNs Zq ψ0 + log ( -1) -pK+αC-β 2.3kT Ceq ψ0

𝑄𝑜𝑥 + 𝑄𝑠𝑠 + 𝑄𝑏 Φsi = Eref − 𝜓0 − − + 𝜒 𝑠𝑜𝑙 + 2𝜙𝑓 𝐶𝑜𝑥 𝑞

∗ 𝑉𝑡ℎ(𝑖𝑠𝑓𝑒𝑡) = 𝑉𝑡ℎ(𝑚𝑜𝑠𝑓𝑒𝑡) + 𝐸𝑟𝑒𝑓 − 𝜓0 −

Φm + 𝜒 𝑠𝑜𝑙 𝑞

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3 -Simulated Threshold Voltage For Formaldehyde

4 -Simulated Transcanductance and drain current

5- OTA Circuit Readout 4

6- Results for Formaldehyde versus temperature

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7- Dynamic simulation frequency

8- Results Comparisons

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Conclusion

 The successful results show the potential of the developed and design of the enzymatic field effect transistor (ENFET) for Lab on chip CMOS development  BioFET can be implemented for detection and monitoring cancer .

References  J. Chermiti et al., Site-binding model as a basis for numerical evaluation of analytical parameters of capacitance-biosensors for formaldehyde and methylamine detection, Sensors and Actuators B: Chemical (2013),  M. Ben Ali et al ., Formaldehyde assay by capacitance versus voltage and impedance measurements using bi-layer  Bio-recognition membrane, Biosensors an Bioelectronics 22(2006) 575–581.  S. Martinoia et al , Modeling ISFET microsensor and ISFET- based microsystems: a review, Sensors and Actuators B 105 (2005) 14–27

Acknowledgements

We would like to thanks Pr. N Benharrats rector of USTO University for giving me the first opportunity to carried out this work, I am also grateful to Dr.Yaroslav Korpan from the Institute of Molecular Biology & Genetics NAS of Ukraine, 150 Zabolotnogo Street, 03680 Kyiv .

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