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Comment

30. 0.0. 2.5. 5.0. 7.5. 10.0. BA. CH2. BCL2. BCL6. BCL7A. BCR. EARLY. LATE. Number of m utations/sample b p = 0.267 p = 0.651 p = 0.010 p = 0.138 p = 0.863.

Number of mutation/sample

a 200

P = 0.115 150

group EARLY LATE

100

50

0 EARLY

b

LATE

25

4

6 15

20

p = 0.003

p = 0.267

3

p = 0.076 4

10 2

PIM1

BPTF

BACH2

10

CXCR4

15

p = 0.075

5

2

0

0

1

5

0

0

15 75 15

p = 0.606

0

5

5

0

0

8

15

75

p = 0.274

p = 0.010

20

p = 0.011 10 SOCS1

LTB

BTG2

50

p = 0.024

6

BCL6

Number of mutations/sample

0

10 RHOH

5

p = 0.040

IRF8

10

25

p = 0.120

10 BTG1

BCL2

50

p = 0.651

4

10

5

25

2

0 30

0

0

0

5

3

4

4

p = 0.193

p = 0.138

p = 0.187

p = 0.074

3

2

20

TCL1A

MYC

CD83

BCL7A

3

2

2 1

10

1

1

0

0

0

0

10.0

2.0 15

30

p = 0.377

7.5

p = 0.863

EARLY

LATE

5

0

0 EARLY

LATE

TMSB4X

0.0

10

10

p = 0.829

1.5

PAX5

2.5

20

CIITA

BCR

5.0

p = 0.844

1.0

0.5

0.0 EARLY

LATE

EARLY

LATE

group EARLY LATE