R Graphics Output

5 10

20

HSP−EV UC−EV HSP−EV UC−EV

10

15

HSP−EV

TSPAN9

UC−EV HSP−EV

CHMP2B

HSP−EV UC−EV

6

UC−EV 10

20

30

0.0

1.0

2.0

3.0

Normalized Counts

0

TSPAN6

4

15

HSP−EV

2

10

20

40

60

15

25

5

10 15 20

0

4

8

12

Normalized Counts

0

Normalized Counts

0 5

Normalized Counts

0

TSPAN1

0

5

Normalized Counts

0

UC−EV

Normalized Counts

5

6

HSP−EV

0 1 2 3 4 5 6

CHMP2A

UC−EV

Normalized Counts

ESCRT/MVB 0

HSP−EV

8

UC−EV

6

4

TSPAN3

4

2

Normalized Counts

0

HSP−EV

2

5

CD9

0

4

Normalized Counts

HSP−EV

Normalized Counts

3

UC−EV

Normalized Counts

8

HSP−EV

6

2

HSP−EV

4

1

Normalized Counts

HSP−EV

2

0

Normalized Counts

5 10

20

20

60

0

10

20

30

Normalized Counts

0

Normalized Counts

0

Normalized Counts

Tetraspanins

0

Normalized Counts

0

Normalized Counts

CD63 CD81 CD82

UC−EV HSP−EV

TSPAN14

UC−EV

TSPAN8

UC−EV

CHMP1A

UC−EV

CHMP3

HSP−EV

UC−EV

TSPAN15

HSP−EV UC−EV

TSPAN13

HSP−EV UC−EV

CHMP1B

HSP−EV UC−EV

CHMP4A

UC−EV

2

4

6

8 10


UC−EV HSP−EV

VPS37B

HSP−EV UC−EV

30

VPS28

20

HSP−EV

10

20

30

0

5

10

15

STAMBP

0

10

HSP−EV

30

UC−EV

Normalized Counts

0

6

10

30

5 10

20

0

50

150

Normalized Counts

0

Normalized Counts

0

IST1

20

HSP−EV

HSP−EV

10

VPS36 UC−EV

Normalized Counts

15

4

15

25

1

2

3

4

5

5 10

20

0

1

2

3

4

5

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0 5

Normalized Counts

CHMP4C

0

UC−EV

UC−EV

Normalized Counts

HSP−EV

0 2 4 6 8

10

STAM

15

5

HSP−EV

10

UC−EV

Normalized Counts

0

2

Normalized Counts

0

HGS

5

6

HSP−EV

0

50

4

UC−EV

Normalized Counts

30

2

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 0 10

VPS26A

25

12

HSP−EV

15

8

Normalized Counts

HSP−EV

5

4

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

CHMP4B CHMP5 CHMP6

UC−EV HSP−EV

MVB12A

UC−EV

TSG101

UC−EV

VPS29

UC−EV

VPS4A

HSP−EV

UC−EV

PDCD6IP

HSP−EV UC−EV

VPS25

HSP−EV UC−EV

VPS35

HSP−EV UC−EV

VPS4B

UC−EV

2

4

6

8


UC−EV HSP−EV

SEC22B SEC23A

HSP−EV UC−EV

12

CLSTN3

0 2 4 6 8

HSP−EV

20

5

10

15

SDCBP

15

0

5

10

15

0

2

4

6

Normalized Counts

Syntenin & Syndecan

10

5

UC−EV

Normalized Counts

4

0

HSP−EV

5

HSP−EV 3

20

15

25

1

2

3

4

0.0

1.0

2.0

3.0

Normalized Counts

0

Normalized Counts

0 5

Normalized Counts

VPS26B

0

SEC13

UC−EV

Normalized Counts

UC−EV 2

CLSTN1

1

HSP−EV

0

150

SDC4

12

50

HSP−EV

8

UC−EV

Normalized Counts

0

5 10

Normalized Counts

0

FLOT1

4

10 15 20

30

HSP−EV

0

5

20

UC−EV

Normalized Counts

0

10

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

8

HSP−EV

6

HSP−EV

4

150

Normalized Counts

HSP−EV

2

50

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

VTA1 VPS33A

Flotillins

UC−EV

FLOT2 SDC1

UC−EV HSP−EV

SCAMP1

UC−EV

HSP−EV

UC−EV

SDCBP2

Vesicle Transport

UC−EV

SCAMP3

HSP−EV UC−EV

SEC23B

UC−EV

5

10

15


UC−EV HSP−EV

VAMP3

HSP−EV UC−EV

6

8

STX4

4

HSP−EV

2

0

2

4

6

SNX33

0

3.0

HSP−EV

8

2.0

6

8

2

4

6

0.0

1.0

2.0

Normalized Counts

0

SNX12

6

1.0

4

HSP−EV

4

UC−EV

Normalized Counts

0.0

2

Normalized Counts

0

10

20

2

4

6

8

5

15

25

0.0

1.0

2.0

3.0

Normalized Counts

0

Normalized Counts

0

SNAP23

2

5

5

Normalized Counts

0

Normalized Counts

SEC31A

0

8

4

UC−EV

Normalized Counts

6

3

3

UC−EV

Normalized Counts

HSP−EV 4

STX3

2

HSP−EV

0

2

SNX3

8

1

HSP−EV

6

UC−EV

Normalized Counts

0

2

SNX1

4

15

1

Normalized Counts

0

HSP−EV

2

10

UC−EV

Normalized Counts

5

UC−EV

Normalized Counts

0

Normalized Counts

0 2 4 6 8

Normalized Counts

UC−EV

0

STXBP3 20

HSP−EV

15

6

HSP−EV

10

4

Normalized Counts

HSP−EV

5

2

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

SEC24C

UC−EV

UC−EV

UC−EV

UC−EV

SNAPIN

HSP−EV

SNX2

SNX5

STX7

VAMP5

HSP−EV

UC−EV

SNX27

HSP−EV UC−EV

STX12

HSP−EV UC−EV

STXBP2

HSP−EV UC−EV

VAMP7

UC−EV

30


HSP−EV

CLTA

UC−EV HSP−EV

COPB1

HSP−EV UC−EV

150

UC−EV 5

10

15

0

10 20 30 40

Normalized Counts

0

AP2A1

0 50

40

HSP−EV

20

8

30

2

4

6

5

10

15

0

5

10

15

Normalized Counts

0

Normalized Counts

0

AP1B1

10

6

20

UC−EV

Normalized Counts

4

10

Normalized Counts

0

Normalized Counts

HSP−EV

5

HSP−EV 2

8

2

4

6

8

2

4

6

8

0

5

10

15

Normalized Counts

0 1 2 3 4 5

Normalized Counts

0

Normalized Counts

0

Normalized Counts

VAPA

0

COPA

UC−EV

Normalized Counts

UC−EV 0

AP2M1

25

HSP−EV

15

6

HSP−EV

5

15

4

HSP−EV

0

10

UC−EV

Normalized Counts

5

2

Normalized Counts

0

UC−EV

Normalized Counts

HSP−EV 0

HSP−EV

30

15

AP1S1

20

10

Normalized Counts

Vesicle Coat

10

5

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0 10

Normalized Counts

VAMP8 VAT1 YKT6

UC−EV HSP−EV

AP1G1

UC−EV

AP2A2

UC−EV

CLTB

UC−EV

COPB2

HSP−EV

UC−EV

AP1M2

HSP−EV UC−EV

AP2B1

HSP−EV UC−EV

CLTC

HSP−EV UC−EV

COPE

UC−EV

1.0

2.0

HSP−EV UC−EV

UC−EV HSP−EV

ATP6V0A2

HSP−EV UC−EV

6

8

HSP−EV

LAMTOR1

UC−EV HSP−EV

ATP6V1E1

HSP−EV

UC−EV

UC−EV

8

8

0

2

4

6

ATP6V0D1

6

6

0

4

8

12

Normalized Counts

Lysosomal

4

4

2.0

HSP−EV

2

2

1.0

5 10

20

1

2

3

2

4

6

0

1

2

3

4

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

COPG2

0

UC−EV

Normalized Counts

0

0.0

UC−EV

Normalized Counts

4

ATP6V1G1

2

HSP−EV

0

ATP6AP2

3.0

HSP−EV

2.0

UC−EV

Normalized Counts

0 1 2 3 4 5

Normalized Counts

0 1 2 3 4 5 6

AP2S1

1.0

12

25

UC−EV

Normalized Counts

0 2 4 6 8

15

Normalized Counts

0 5

HSP−EV

0.0

4

Normalized Counts

UC−EV

Normalized Counts

HSP−EV

6

3

HSP−EV

4

2

Normalized Counts

HSP−EV

2

1

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0.0

Normalized Counts

COPG1 COPZ1 AP1M1

UC−EV HSP−EV

AP3S1

UC−EV

ATP6V1A

UC−EV

LAMTOR2

UC−EV

ATP6AP1

HSP−EV UC−EV

ATP6V1B2

HSP−EV UC−EV

ATP6V0A1

HSP−EV UC−EV

LAMTOR5

Annexins

2

4

6

8

HSP−EV UC−EV HSP−EV

HSP−EV UC−EV

RAB13 RAB14

UC−EV HSP−EV

RAB21

HSP−EV UC−EV

40

RAB Family

30

0 5

15

25

HSP−EV

20

20

30

40

20

60

0

20

40

60

80

Normalized Counts

0

ANXA4

10

10

Normalized Counts

0

ANXA3

0

15

300

HSP−EV

Normalized Counts

10

UC−EV

Normalized Counts

25

5

200

20

40

60

10

20

30

20

40

0

20

40

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

ANXA10

0 2 4 6 8

RAB1B

UC−EV

Normalized Counts

UC−EV 15

RAB11B

5

HSP−EV

0

UC−EV

15

0

ANXA6

10

8

HSP−EV

5

6

100

Normalized Counts

0

HSP−EV

0

4

25

UC−EV

Normalized Counts

2

15

Normalized Counts

0 5

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 0

HSP−EV

15

60

HSP−EV

10

40

Normalized Counts

ANXA2

5

20

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

ANXA1 ANXA11 ANXA13

UC−EV HSP−EV

UC−EV

ANXA7

UC−EV

UC−EV

RAB22A

HSP−EV

UC−EV

ANXA5

HSP−EV UC−EV

RAB10

HSP−EV UC−EV

RAB1A

HSP−EV UC−EV

RAB23

UC−EV

1

2

3

4

HSP−EV UC−EV 2

3

4

5

UC−EV HSP−EV

RAB7B

HSP−EV UC−EV

4

6

8

UC−EV HSP−EV

RAB4A

UC−EV HSP−EV

RAB8B

HSP−EV

UC−EV

UC−EV

1.0

2.0

3.0

RAB18

0.0

HSP−EV

3.0

2

UC−EV

Normalized Counts

0

10 20 30 40

20

40

60

0

5

10

15

Normalized Counts

0

Normalized Counts

0

RAB6A

2.0

8

HSP−EV

1.0

6

1

2

3

4

15

25

15

25

0

2

4

6

Normalized Counts

0 5

Normalized Counts

0 5

Normalized Counts

0

Normalized Counts

RAB2A

0.0

4

10 20 30 40

Normalized Counts

0

UC−EV

Normalized Counts

5

RAB43 4

HSP−EV

3

2

RABGGTB

2

UC−EV

Normalized Counts

0

HSP−EV

1

4

RAB5C

0

3

HSP−EV

0.0 1.0 2.0 3.0

1

2

UC−EV

Normalized Counts

0

1

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

HSP−EV

3.0

HSP−EV

2.0

2.0

Normalized Counts

HSP−EV

1.0

1.0

Normalized Counts

0.0

Normalized Counts

HSP−EV

0.0

Normalized Counts

0

Normalized Counts

RAB25 RAB35 RAB5B

UC−EV HSP−EV

RAB7A

UC−EV

RAB20

UC−EV

RAB4B

HSP−EV

UC−EV

RAB8A

HSP−EV UC−EV

RAB39A

HSP−EV UC−EV

RAB5A

UC−EV

RABGAP1

Other GTPases & related

10

20

30


HSP−EV

RHOC

UC−EV HSP−EV

RAC2

HSP−EV UC−EV

0 1 2 3 4 5

60

5

15

25

0

10

30

Normalized Counts

0

RAC1

5

UC−EV

Normalized Counts

40

HSP−EV

4

ROCK2 UC−EV

3

HSP−EV 20

20

Normalized Counts

0

4

6

8

15

25

5

10

15

0

2

4

6

8

Normalized Counts

0

Normalized Counts

0 5

ARHGDIA

2

UC−EV 5 10

RHOB

0

HSP−EV

HSP−EV

1

5

2

Normalized Counts

0

10 20 30 40

5

10 15 20

1

2

3

4

0

4

8

12

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

ARF6

0

4

UC−EV

UC−EV

Normalized Counts

3

CDC42

6

2

20

HSP−EV

4

1

10

UC−EV

Normalized Counts

0

5

Normalized Counts

0

ARHGAP18

2

HSP−EV HSP−EV

0

8

Normalized Counts

UC−EV

Normalized Counts

6

HSP−EV

2.0

4

Normalized Counts

HSP−EV

1.0

2

Normalized Counts

0

Normalized Counts

HSP−EV

0.0

Normalized Counts

0

Normalized Counts

ARF1 ARFGEF2 ARHGAP1

UC−EV HSP−EV

ARHGEF1

UC−EV

RACGAP1

UC−EV

RHOG

UC−EV

ARF4

HSP−EV

UC−EV

ARHGEF16

HSP−EV UC−EV

RHOA

HSP−EV UC−EV

ROCK1

HSP−EV UC−EV

ARF5

UC−EV

20

40

60

HSP−EV UC−EV

ITGB5

HSP−EV UC−EV

UC−EV

HSP−EV

ITGAV

HSP−EV

Some Receptors & CD Markers

300

60

0

20

40

ITGA1

100

UC−EV

Normalized Counts

0 20

HSP−EV

0

30

UC−EV

Normalized Counts

20

2

4

6

8

2

4

6

0

1

2

3

4

Normalized Counts

0

Normalized Counts

0

CEACAM1

15

HSP−EV

HSP−EV

10

UC−EV 120

ITGA6

80

HSP−EV

40

10

HSP−EV

0

UC−EV

Normalized Counts

0

EPCAM

UC−EV

5

60

Normalized Counts

HSP−EV

0

20

100

UC−EV

Normalized Counts

0

60

Normalized Counts

0 20

1

2

3

4

1.0

2.0

1.0

2.0

3.0

0

2

4

6

Normalized Counts

0.0

Normalized Counts

0.0

Normalized Counts

0

Normalized Counts

ARHGEF39

Normalized Counts

8

HSP−EV

6

HSP−EV

4

150

Normalized Counts

Adhesion Molecules

2

50

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

ARHGAP12 CDC42SE2 RHOF

UC−EV HSP−EV

CEACAM5

UC−EV

ITGA2

UC−EV

ITGB1

UC−EV

ITGB6

HSP−EV

UC−EV

CEACAM6

HSP−EV UC−EV

ITGA3

HSP−EV UC−EV

ITGB4

HSP−EV UC−EV

ADGRE5

UC−EV

5

10

15


HSP−EV UC−EV

HSP−EV

FGFR4

UC−EV HSP−EV

PVRL2

HSP−EV UC−EV

8

0

20

40

60

CD55

6

HSP−EV

4

15

20

40

60

1

2

3

4

5

0

5

10

15

Normalized Counts

0

Normalized Counts

0

CD44

2

30

10

HSP−EV

0

UC−EV

Normalized Counts

0 10

UC−EV

Normalized Counts

20

20

5

Normalized Counts

0

1

2

3

4

1

2

3

4

5

2

4

6

0

5

15

25

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

ADGRG6

0 1 2 3 4 5

PVR

UC−EV

Normalized Counts

UC−EV 5 10

F11R

0

HSP−EV

6

5 10

CD47

4

UC−EV

Normalized Counts

0

HSP−EV

2

8 10

HSP−EV

0

15

6

UC−EV

Normalized Counts

10

4

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 5

HSP−EV

0

2

Normalized Counts

0

HSP−EV

20

40

Normalized Counts

CD276

5 10

20

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

ADGRG1 CD14 CD151

UC−EV HSP−EV

CD46

UC−EV

CD59

UC−EV

GPRC5A

UC−EV

SCARB1

HSP−EV

UC−EV

CD46

HSP−EV UC−EV

EGFR

HSP−EV UC−EV

GPRC5C

HSP−EV UC−EV

SCARB2

UC−EV

10

20

30


1

2

3

4

5

HSP−EV

GNG12

UC−EV HSP−EV

ACTG1

HSP−EV UC−EV

10 20 30 40

GNB1

0

HSP−EV

60

UC−EV

Normalized Counts

0

UC−EV

40

8

60

20 40 60 80

10 20 30 40

0

2

4

6

8

Normalized Counts

0

Normalized Counts

0

GNAI2

20

ACTA1 6

40

12

HSP−EV

0

HSP−EV 4

GNB2L1

2

HSP−EV

0

20

8

UC−EV

Normalized Counts

UC−EV

Normalized Counts

0

GNAS

15

30

HSP−EV

10

20

4

Normalized Counts

0

GNAI1

5

10

UC−EV

Normalized Counts

0

20 40 60 80

Normalized Counts

0

Normalized Counts 40

80

4

8

12

0 5

15

25

Normalized Counts

0

Normalized Counts

0

Normalized Counts

G−Proteins

0

80

UC−EV

Normalized Counts

4

HSP−EV

3

60

HSP−EV

2

40

Normalized Counts

HSP−EV

1

20

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

TFRC GNA11 GNA13

UC−EV HSP−EV

GNAI3

UC−EV

GNB1L

UC−EV

ACTL6A

HSP−EV

UC−EV

GNAQ

HSP−EV UC−EV

GNB2

HSP−EV UC−EV

GNG5

Cytoskeleton

UC−EV

ACTN1

UC−EV

2

4

6


DCTN2

HSP−EV UC−EV

UC−EV HSP−EV

DCTN4

HSP−EV UC−EV

4

6

8

CORO1C

2

HSP−EV

0

UC−EV 100

150

0

2

4

6

8

Normalized Counts

50

ARPC5

0

HSP−EV

150

HSP−EV

10

20

30

10

20

30

40

0

5

10

20

Normalized Counts

0

Normalized Counts

0

HSP−EV

50

12

200

400

4

8

12

10

30

0

20

40

60

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

ACTR1A

0

UC−EV UC−EV

Normalized Counts

8

HSP−EV

12

4

ARPC1B

0 2 4 6 8

UC−EV

Normalized Counts

0

ARPC4

UC−EV

Normalized Counts

40

Normalized Counts

0 1 2 3 4 5 6

ARPC1A

20 40 60 80

30

25

HSP−EV

0

20

15

UC−EV

Normalized Counts

10

5

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 0

CORO1B

6

25

HSP−EV

4

15

Normalized Counts

HSP−EV

2

5

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

ACTN4 ACTR2 ACTR3

UC−EV HSP−EV

ARPC2

UC−EV

CFL1

UC−EV

COTL1

UC−EV

EZR

HSP−EV

UC−EV

ARPC3

HSP−EV UC−EV

CKAP5

HSP−EV UC−EV

DCTN1

HSP−EV UC−EV

FLNA

UC−EV

40

80


HSP−EV UC−EV

2

4

6

8

UC−EV HSP−EV

VCL

UC−EV HSP−EV

DYNC1I2

HSP−EV UC−EV

4

TUBB4B 3

HSP−EV

2

10 15 20

5

10

15

0

20

40

60

Normalized Counts

0

TUBA1C

1

5

Normalized Counts

0

HSP−EV

0

UC−EV

Normalized Counts

0

60

100

200

50 100

50

150

0 2 4 6 8

12

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

GSN

0 2 4 6 8

DYNC1H1

UC−EV

Normalized Counts

UC−EV 12

TUBGCP3

0 2 4 6 8

HSP−EV

3

300

HSP−EV

2

200

40

TLN1

1

100

20

Normalized Counts

0

HSP−EV

0

UC−EV

Normalized Counts

0

UC−EV

Normalized Counts

6

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 30

HSP−EV

20

4

TUBB2A

10

2

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0 1 2 3 4 5

Normalized Counts

HSP−EV

0 1 2 3 4 5 6

Normalized Counts

0

Normalized Counts

FLNB MSN RDX

UC−EV HSP−EV

TUBA4A

UC−EV

TUBB8

UC−EV

DYNC1LI2

HSP−EV

UC−EV

TUBB

HSP−EV UC−EV

TUBG1

HSP−EV UC−EV

WASF2

Motor Proteins

UC−EV

DYNLL1

UC−EV

20

40

60

HSP−EV UC−EV

UC−EV HSP−EV

MYO1D

HSP−EV UC−EV

UC−EV

2

3

4

HSP−EV

MYO18A

HSP−EV

Phospholipid (PS) Binding

0

5

10

15

MYH9

50 100

1

HSP−EV

0

UC−EV

Normalized Counts

0

10

20

30

0 1 2 3 4 5

Normalized Counts

0

Normalized Counts

0.0 1.0 2.0 3.0

KIF4A

30

HSP−EV

HSP−EV

20

MYL6 UC−EV

Normalized Counts

UC−EV

20

MYH14

5 10

150

HSP−EV

0

50

UC−EV

Normalized Counts

0

KIF2A UC−EV

10

30

Normalized Counts

0 1 2 3 4 5

HSP−EV

0

20

60

UC−EV

Normalized Counts

10

40

Normalized Counts 5

10

15

2

4

6

1.0

2.0

3.0

0

10

20

30

Normalized Counts

0.0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

DYNLRB1

Normalized Counts

HSP−EV 0

HSP−EV

30

20

Normalized Counts

0

Normalized Counts

HSP−EV

10

30

Normalized Counts

0 10

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

DYNLL2 KIF1BP KIF23

UC−EV HSP−EV

KIF5B

UC−EV

MYL1

UC−EV

MYO1B

UC−EV

MYO6

HSP−EV

UC−EV

MYH10

HSP−EV UC−EV

MYL12A

HSP−EV UC−EV

MYO1C

HSP−EV UC−EV

MFGE8

UC−EV

10

20

30


HSPA5

UC−EV HSP−EV

HSPB1

HSP−EV UC−EV

300

HSP−EV

200

100 150

0 20

60

HSPA13

100

50

HSP−EV

0

UC−EV

Normalized Counts

0

50 100

200

400

0

5

10

20

Normalized Counts

0

Normalized Counts

0

HSP90AA1

80

12

HSP−EV

40

12

8

UC−EV

Normalized Counts

8

4

Normalized Counts

0

Normalized Counts

5

10

15

0.0

1.0

2.0

3.0

Normalized Counts

0 2 4 6 8

Normalized Counts

0

Normalized Counts

PLSCR3

0

HSPA9

UC−EV

Normalized Counts

HSP−EV 4

HSPA4L

0

HSP−EV

15

60

HSP90B1

10

40

HSP−EV

5

60

20

Normalized Counts

0

HSP−EV

0

UC−EV

Normalized Counts

0 20

UC−EV

Normalized Counts

HSP−EV

15

15

HSP−EV

10

10

Normalized Counts

Heat Shock Proteins

5

5

Normalized Counts

0

Normalized Counts

Phospholipid Transfer

0

Normalized Counts

0

Normalized Counts

PLSCR1

UC−EV

HSP90AB1

UC−EV

UC−EV

UC−EV

PLTP

HSP−EV

HSPA1A

HSPA6

HSPBP1

HSP−EV

UC−EV

HSP90AB2P

HSP−EV UC−EV

HSPA4

HSP−EV UC−EV

HSPA8

HSP−EV UC−EV

HSPD1

UC−EV

5

10 15 20


HSP−EV UC−EV

8

YWHAZ

UC−EV HSP−EV

ENO1

UC−EV HSP−EV

PGM2

HSP−EV UC−EV

100

30

HSP−EV

50

10

40

80

120

10 20 30 40

0 5

15

25

Normalized Counts

0

Normalized Counts

0

YWHAE

0

0

UC−EV

Normalized Counts

6

60

HSP−EV

0 2 4 6 8

PGM1

UC−EV

Normalized Counts

UC−EV 4

PKM

2

HSP−EV

0

120

YWHAQ

6

80

HSP−EV

4

40

40

HSP−EV

2

UC−EV

Normalized Counts

0

20

Normalized Counts

0

15

25

40

80

120

0.0

1.0

2.0

3.0

Normalized Counts

0

Normalized Counts

0 5

Normalized Counts

HSPH1

0

250

UC−EV

Normalized Counts

100

40

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 0

HSP−EV

12

20

Normalized Counts

0

HSP−EV

8

300

Normalized Counts

YWHAB

4

100

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

HSPE1 HSPA14

14−3−3 Poteins

UC−EV

YWHAG YWHAH

UC−EV HSP−EV

ENO2

UC−EV

PGM3

HSP−EV

UC−EV

SFN

Glucose Metabolism

UC−EV

PGK1

HSP−EV UC−EV

MDH1

UC−EV

5

15

25


HSP−EV

PSMA2

UC−EV HSP−EV

PSMA6

HSP−EV UC−EV

25

UC−EV

15

60

ALDOC

0 5

40

HSP−EV

30

20

150

40

80

120

0

40

80

Normalized Counts

0

GAPDH

20

PSMA5

HSP−EV

10

HSP−EV

0

50

Normalized Counts

0

20

40

5

15

25

2

4

6

0

1

2

3

4

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

HK1

0

UC−EV UC−EV

Normalized Counts

PSMA1

UC−EV

Normalized Counts

HSP−EV

10 20 30 40

25

ALDOA

0

15

HSP−EV

30

UC−EV

Normalized Counts

0 5

30

PFKP

10

25

10

Normalized Counts

0

HSP−EV

0

15

100

UC−EV

Normalized Counts

5

50

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 0

HSP−EV

40

30

Normalized Counts

HSP−EV

20

10

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

GPI PFKL PFKM

UC−EV HSP−EV

LDHA

UC−EV

PSMA3

UC−EV

PSMA7

HSP−EV

UC−EV

LDHB

HSP−EV UC−EV

TPI1

Proteasome

UC−EV

PSMA4

HSP−EV UC−EV

PSMB1

UC−EV

5

10

15


5

UC−EV HSP−EV

PSMD13

HSP−EV UC−EV

30

PSMD1

20

HSP−EV

10

5

10

15

0

5 10

20

PSMC3

0

UC−EV

Normalized Counts

0

HSP−EV

20

4

15

5

10

15

4

8

12

0

5

10

15

Normalized Counts

0

Normalized Counts

0

PSMB7

10

3

UC−EV

Normalized Counts

2

15

10

HSP−EV

5

HSP−EV 1

10

5

Normalized Counts

0

5 10

20

15

25

15

25

0

10

20

30

40

Normalized Counts

0 5

Normalized Counts

0 5

Normalized Counts

0

Normalized Counts

PSMB3

0

PSMD12

UC−EV

Normalized Counts

UC−EV 0

HSP−EV

8

5

PSMC2

6

UC−EV

Normalized Counts

0

HSP−EV

4

40

PSMB6

2

20

30

HSP−EV

0

15

20

UC−EV

Normalized Counts

10

10

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

HSP−EV 5

PSMC6

0

HSP−EV

20

25

Normalized Counts

HSP−EV

5 10

15

Normalized Counts

0 5

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

PSMB2 PSMB4 PSMB5

UC−EV HSP−EV

PSMB8

UC−EV

PSMC4

UC−EV

PSMD10

UC−EV

PSMD14

HSP−EV

UC−EV

PSMC1

HSP−EV UC−EV

PSMC5

HSP−EV UC−EV

PSMD11

HSP−EV UC−EV

PSMD2

UC−EV

2

4

6

8 10


UC−EV HSP−EV

SLC1A5

HSP−EV UC−EV

15

SLC12A2

10

HSP−EV

5

0 2 4 6 8

PSME3

0

12

HSP−EV

8

8

2

4

6

8

0

5

10

15

20

Normalized Counts

0

PSMD9

6

UC−EV

Normalized Counts

4

UC−EV

Normalized Counts

0

Normalized Counts

0 1 2 3 4 5 6

PSMD8

4

SLC16A3

HSP−EV

2

HSP−EV 15

HSP−EV

10

PSME2

5

10 20 30 40

HSP−EV

0

UC−EV

Normalized Counts

0

8

5

10

15

2

4

6

8

5

10 15 20

0

5

10

15

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0

Normalized Counts

PSMD4

0

80

6

PSMD7 UC−EV

Normalized Counts

60

4

HSP−EV

0 1 2 3 4 5

40

UC−EV

Normalized Counts

20

2

Normalized Counts

0

Normalized Counts

UC−EV

Normalized Counts

Solute Carriers 0

HSP−EV

20 40 60 80

10 15 20

Normalized Counts

5

HSP−EV

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

PSMD3 PSMD5 PSMD6

UC−EV HSP−EV

UC−EV

PSMG1

UC−EV

SLC12A7

UC−EV

SLC25A5

HSP−EV

UC−EV

PSME1

HSP−EV UC−EV

PSMG2

HSP−EV UC−EV

SLC16A1

HSP−EV UC−EV

SLC29A1

UC−EV

2

4

6

SLC38A1

HSP−EV UC−EV

UC−EV

HSP−EV

HSP−EV

UC−EV

1

2

3

4

HSP−EV

SLC9A3R2

UC−EV HSP−EV

SLC38A5

HSP−EV UC−EV

10

20

SLC7A1

5

HSP−EV

0

25

5 10

20

0

5

10

15

Normalized Counts

0

SLC44A2

2.0

UC−EV

Normalized Counts

0

15

Normalized Counts

0 5

SLC44A1

1.0

8

HSP−EV

0.0

6

UC−EV

Normalized Counts

SLC9A3R1 3.0

HSP−EV

2.0

4

SLC6A8

1.0

2

HSP−EV

0.0

UC−EV

Normalized Counts

0

20

40

1

2

3

4

0 5

15

25

Normalized Counts

0 2 4 6 8

Normalized Counts

0

Normalized Counts

0

Normalized Counts

SLC31A1

0 1 2 3 4 5 6

12

SLC3A2 UC−EV

Normalized Counts

8

20 40 60 80

Normalized Counts

0

HSP−EV

0 1 2 3 4 5

4

6

UC−EV

Normalized Counts

0

4

Normalized Counts

UC−EV

Normalized Counts

8 10

HSP−EV

6

HSP−EV

4

2

Normalized Counts

0

Normalized Counts

HSP−EV

2

10 20 30 40

Normalized Counts

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

SLC2A1 SLC38A2 SLC39A10

UC−EV HSP−EV

UC−EV

SLC7A11

UC−EV

SLC19A1

UC−EV

SLC39A14

HSP−EV

UC−EV

SLC4A2

HSP−EV UC−EV

SLC7A5

HSP−EV UC−EV

SLC35F6

HSP−EV UC−EV

SLC39A6

UC−EV

5

10

15

HSP−EV UC−EV HSP−EV UC−EV HSP−EV UC−EV 4

ABCE1 3

HSP−EV

2

UC−EV 5

10

15

20

0

5 10

20

Normalized Counts

0

HSP−EV

1

5

1.0

2.0

1

2

3

4

1

2

3

4

0

1

2

3

4

5

Normalized Counts

0

Normalized Counts

0

Normalized Counts

0.0

Normalized Counts

SLC4A7

0

4

UC−EV

Normalized Counts

6

ABCC4

4

3

SLC7A6

2

ABC Transporters Normalized Counts

2

HSP−EV

0

1

UC−EV

Normalized Counts

10 15 20

HSP−EV

5

0

Normalized Counts

HSP−EV

0

Normalized Counts

0

Normalized Counts

SLC44A4 SLC5A3 SLC5A6

UC−EV HSP−EV

ABCC1

UC−EV

ABCF2

HSP−EV

UC−EV

ABCC3

HSP−EV UC−EV

ABCG2

UC−EV

R Graphics Output

R Graphics Output

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