qq q q q q q q q q q q q q q qq q q q q q q q q q q q. â2.0. â1.5. â1.0. â0.5. 0.0. 0.5. Boersma Breast : all. ZBTB7A. ARHGEF12. Pâvalue:4.9eâ10; P earson R:0.58.
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●
●
●● ●
−1.2
−0.8
1.0
●●
0.5
● ●
● ● ● ●
● ●
●
● ●
● ● ● ● ●●
−2.0
● ●●
●
●
● ● ●
1.6 ●
●
−1.2
−0.8
−0.4
Boersma Breast : all
●
● ● ● ● ● ●
● ●●
● ● ●
● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●●●
● ●
● ● ●
●
●
● ● ● ● ● ●●● ● ●
● ● ● ● ● ● ● ● ●
● ●
●
● ●● ● ● ●● ● ● ● ●
● ●●
−1.5
● ● ●
● ●● ●●
●
−1.0
●
1.6
●
● ●
● ●
●
1.2
2.0 1.5 SRC
●
●
Boersma Breast : all
●
● ● ● ●● ● ●
●
●
BCL6
●
●
●●
●
●
BCL6
●
●
● ●
●
● ● ● ●● ●
−1.6
●
●
●
●
−0.4
● ●
●
● ● ●
0.8
−1.6
●
●
●
●
● ● ●
● ● ●
●
● ●
●
● ● ●
● ● ●
● ● ●
● ● ●● ● ● ● ● ●
●
● ● ●●
● ●● ● ● ● ● ●
●
0.4
●
0.5
●
●
MAPK10
1.0
●
●●
● ●
●
●
●
●
●
● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
●
●
● ● ● ●
●
●
●
●
●
● ●
● ●
● ●
● ●
● ●
●
●
●
● ●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
P−value:0.15; Pearson R:0.15
●● ●
P−value:0.0033; Pearson R:−0.3
SRC
●●
●
●
−1.0
P−value:0.72; Pearson R:0.037
1.5
●
1.2
● ●
0.8
●
● ● ●
0.4
●
MAPK10
2.0
●
Boersma Breast : all
P−value:0.0066; Pearson R:0.28
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●
−1.2
−0.8
3.0
●
2.5 2.0
● ● ●●
●
●
●
●●● ● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ●
● ●
● ●● ● ●● ● ●● ● ●
●
● ●
●
●
●
● ●
● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●
● ● ●
●
−2.0
● ●
●
●
● ● ●
0.4 0.0
●
●
−1.6
● ●
●
●
● ● ● ● ●
●● ●● ●
−1.2
−0.8
−0.4
Boersma Breast : all
●
●
●
●
Boersma Breast : all
●
●
● ●● ● ●● ●● ●● ●● ● ● ●
BCL6
●
● ● ●
●
● ●
●
BCL6
● ●
● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●
●
−0.4
●
●
● ● ●
−1.5
−1.0
●
0.4
1.5
●
−1.6
1.5
●
●
● ● ●
●
●
● ●
● ● ● ●
●
● ●
●
●
● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●●
●
●
●
● ●
●
0.0
● ●
● ●
● ●● ●
● ●
●
●●
●
●●
●
●
−0.4
●
●
●
● ●
●
●
● ●
● ●
●
●
●
●
● ● ● ● ●● ● ●●●
●●
●● ● ● ● ●
● ● ●
●
● ● ●
●
● ● ●
−0.8
● ● ●
MAPK8
●
●
●
●
●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
P−value:1.4e−06; Pearson R:0.47
● ●
P−value:0.87; Pearson R:0.017
●
●
●
● ●
●
●
−1.0
P−value:0.4; Pearson R:0.088
●
● ●
●
● ● ● ● ● ●
●
−0.4
2.5
●
●
2.0
LLGL1
● ●
●
● ●
●
●
−0.8
● ●
●
●
MAPK8
3.0
●
●
LLGL1
Boersma Breast : all
P−value:1.7e−09; Pearson R:0.57
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ● ● ●●
● ● ●●
● ● ●
● ●
●
●
● ● ● ● ● ●●
●
●
●
−1.8
● ● ●
●
−1.6
−1.2
−0.8
−0.4
−1.0
●
−1.4
●
●
● ●
● ● ●●
●
● ●● ● ●● ●●● ● ● ●● ●
●● ● ● ● ● ●●
● ● ●● ● ● ●
● ● ● ● ● ●
●
●● ● ● ●
● ● ●
●
●● ●● ● ● ●● ●
●
●
● ●
●
●●
●
● ●
−1.8
MAP2K7
● ●
●
● ●
●●
●
● ●
−2.0
−0.4
Boersma Breast : all
●
●
−0.8
Boersma Breast : all
●
●
−1.2
BCL6
●
●
●
BCL6
●
●
●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●
−1.6
●
●
●
●
●
●
−1.5
−1.0
●
●
−1.8
● ●
●
● ●
●
●
●
−2.2
●●
●
● ● ● ●
● ●● ● ●
●●
● ● ●●●● ● ● ● ● ●● ● ●● ●● ● ● ● ● ● ●●
−2.6
● ●
●
●
DLG2
●
● ●
● ● ●● ● ● ●
●
●
●●
● ●
●
● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●
●
● ● ●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.009; Pearson R:−0.27
●
● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●●
●
−1.4
MAP2K7
● ●
●
−1.8
●
●
−2.2
●
−2.6
●
●
●
DLG2
●
●
P−value:0.99; Pearson R:0.0019
−1.0
● ●
P−value:7.7e−12; Pearson R:0.63
Boersma Breast : all
P−value:0.015; Pearson R:0.25
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●● ● ●
● ●
●
● ●
●
●
●
●
● ●
●
● ●
●
● ●
●
● ●
●
●
● ●
−1.2
−0.8
2.5
● ●
●
●
● ● ● ● ● ●● ● ● ●●
●
●
●
●● ●● ● ●●
●
●
●
●
●
●
−1.2
● ●
● ●
● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ●● ● ● ●● ● ● ● ●
●
●
●
● ●
● ● ●
● ●
−1.5
−1.0
2.0 2.5
●
−0.8
−0.4
●
● ●
● ●
●
● ●
2.0
●
●
●
●
● ● ●
●
● ●
●● ●
●
●
●
● ●●
●
● ●
●
● ●
●
● ●
●● ●● ●● ● ● ● ● ● ●● ● ●
● ●
●● ● ●
●
● ●
● ●
●
●
● ●
●
● ●
●
●●
●
● ●● ●
●● ● ●
● ●
●
●
●
● ● ●●
1.5
●● ●●
−2.0
●
●
●
1.0
0.5
ARHGEF12
0.0 −0.5
●
●
0.5
●
●
● ● ●● ● ● ●
●
●
● ●● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●
Boersma Breast : all
●
● ● ●●● ●●● ● ●
●
Boersma Breast : all
●
●
● ●
BCL6
●
●
● ● ● ●
● ● ●
−1.6
●
●
●
●
−0.4
●
●
●
●
BCL6
●
● ●
●
● ●
0.0
−1.6
●
●
●
YES1
●
−0.5
●●
● ●
●
●
●
● ● ●
●
● ●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.64; Pearson R:0.049
●
● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●
●
●
●
●
●
1.5
● ●●
●
●
● ●
●
● ●
●
●
1.0
● ●
● ●
0.5
● ●
P−value:4.9e−10; Pearson R:0.58
0.5
●
●
0.0
ARHGEF12
●
●
0.0
● ●
YES1
● ●
P−value:0.0014; Pearson R:−0.32
Boersma Breast : all
P−value:0.58; Pearson R:−0.058
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ●●● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ●
● ●
●
●
●
−0.5
●
−1.2
−0.8
1.5 0.5
●● ●
●
●
●
● ● ●
●
● ● ● ● ● ● ●
● ● ● ● ●
●●
● ● ● ● ●● ●
●
●
●●
● ● ●
● ●● ●
●
−0.5
SCRIB
●
● ●
● ● ● ● ●●●● ● ●●● ● ● ●● ●● ● ● ●●● ● ● ●
● ●●
●
●
●●
●
−2.0
−0.4
Boersma Breast : all
●
●
−0.8
Boersma Breast : all
●
●
−1.2
●
BCL6
●
●
1.0 −1.6
−1.5
−1.0
●
1.0
●
● ●●●●
●
●
●
−0.4
●
●
●●
●
●
BCL6
2.5
−1.6
● ●●
●
● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●● ●●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ●
●
0.5
●
●
● ●
●
● ●
● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
0.0
●
●● ● ●
−0.5
●
●
DLG3
●
●
●
●
●
● ●
−2.0
ZBTB7A
●
● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●●
● ●
●
●
●
−1.5 ZBTB7A
Biology Open | Supplementary Material
●
●
● ●
●
●
−1.0
P−value:2.4e−05; Pearson R:−0.42
●●
●
●● ●
0.5
●
●
● ● ●
P−value:0.14; Pearson R:−0.15
1.5
●●
● ●
0.5
SCRIB
●
●
0.0
● ●
−0.5
●
●
DLG3
●
P−value:0.0051; Pearson R:0.29
Boersma Breast : all
P−value:0.45; Pearson R:0.079
2.5
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
−2.2
●
●●
●
●● ●
● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●
● ● ●
● ● ●
●
●
● ●
● ●
● ●
● ●
●
●
●
●
−1.2
−1.4
−1.6
●
−0.8
−1.6 −1.8 −2.0
● ● ● ●
●●
●
● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ●
−2.2
DLG1
●
●
●
●
●
●●
● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●
●
●
●
●
● ● ●
● ●●
● ● ●
−2.0
−1.4
● ● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●
●
● ●
●
●
●
●
● ● ● ●
● ● ● ●
●
−1.2
−0.8
−0.4
Boersma Breast : all
● ● ●
●
● ●
Boersma Breast : all
●
●
●
BCL6
●
●
●
●●
●
●●
BCL6
●
●
●
●
−1.6
●
●
●
●
−0.4
●
●
● ● ●
●
●
● ● ●
● ● ● ●●
● ●
●
●
−1.5
−1.0
●
●
● ●
●
● ●
● ● ●
●● ● ●
● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●
● ●
●
● ● ●
● ● ● ● ● ●● ● ●●
● ●
● ●
● ●● ● ●● ● ●
● ●
● ●
●
● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
P−value:0.058; Pearson R:−0.2
● ●● ● ● ● ●● ● ● ● ●
●
● ●
●
● ●
● ●●
●●
●●
● ●
−1.4
●
● ● ●
● ●
−1.8
●
●
●
● ●
−2.2
●● ● ●
● ●
●
−1.0
●
P−value:1.1e−07; Pearson R:0.51
● ● ● ●● ● ●
DLG4
−1.8 −2.0
DLG1
● ●
●
● ●
−1.8
●
●
−2.2
●
P−value:0.024; Pearson R:−0.23
−1.6
●
●
●
DLG4
● ●
P−value:6.8e−05; Pearson R:0.4
Boersma Breast : all
−1.4
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●● ● ● ●
●●
●
● ●
● ●
● ●
●
−1.2
0.8
−1.6
−0.8
● ●
●
●
−0.4
1.0
−0.4
Boersma Breast : all
●
● ● ●
● ● ● ● ●
● ●
● ●
● ●
●●
●
● ●
●
● ● ● ● ●
●
●
● ● ● ● ●● ● ●
●
●
●
● ● ● ●●
●
● ● ● ●
●
● ●
● ●
−2.0
−0.8
Boersma Breast : all
● ●
●
−1.2
●
BCL6
● ● ● ●●
● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ●● ●
●
●
BCL6
● ● ●
●
−1.6
● ●
●
−0.4
●
●
● ● ● ● ● ● ● ● ●● ● ●● ● ●● ● ● ● ●● ● ● ●● ●● ●● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●
−1.5
−1.0
●
1.0
●
●
●
●
●
0.0
●
● ●
●
● ●
●
● ●
● ●● ● ● ● ●● ●● ●● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ●● ●
●
●
−1.0
−0.4
●● ● ● ● ●● ● ● ●
●
●
●
● ●
●
● ● ●
●
●
●
●
●
● ●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
●● ● ● ●
●● ●
● ●● ● ● ● ● ● ●● ●
●
−2.0
●
●●
● ● ● ●
● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●
● ●
●
LLGL2
●
0.4
●
● ● ●
●
● ● ●
● ● ● ●● ●
● ● ● ● ●
●
● ●
●
−1.0
●
P−value:0.00012; Pearson R:−0.38
●
● ●
0.0
● ● ● ●● ●
●
●
P−value:5e−08; Pearson R:−0.52
0.4
●
●
MAPK9
● ●
0.0
●
●● ●
0.0
MAPK9
●
● ●●
● ● ●
−1.0
●
●● ●
●
−2.0
●
LLGL2
●
P−value:0.4; Pearson R:0.087
Boersma Breast : all
P−value:5.1e−10; Pearson R:0.58
0.8
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●●
● ●
●
● ●
●
● ●
●
●●
● ● ●
●●
●
●
−1.2
−0.8
● ● ●●
●
●
● ● ●
●
● ● ●●
●
●●
●
●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●
● ●
●
● ●
−2.0
−0.4
−1.5
−1.0
●
1.5
● ●
1.0
● ●
●
●●
●
● ●
●
● ● ● ●
●
●
●
● ●
0.5
● ●
●
−0.8
Boersma Breast : all
0.0
0.8
ARHGEF11
0.4 0.0
●
−1.2
Boersma Breast : all
● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●●
●
●
BCL6
●● ●
● ● ●
● ● ● ●● ● ● ● ● ●● ● ● ● ● ●●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
BCL6
●
● ●
●
● ●
●
−1.6
●
●
1.0
−0.4
●
●
●
●
●
● ● ●
● ● ●● ●● ●● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ●●●
−0.5
1.2
−1.6
●
●
●
●
●
● ●● ● ● ● ●
● ●
●
● ●
● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ● ● ●
●
●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
P−value:0.15; Pearson R:−0.15
● ● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●
● ●
ARHGEF1
0.0
●
●
●
● ●
●
−1.0
P−value:0.01; Pearson R:0.26
● ●
● ●
0.5
●
● ● ● ●●
●
●
●
0.0
●
P−value:0.024; Pearson R:−0.23
0.8
●
●
● ●
0.4
ARHGEF11
●
●
−0.5
● ●
ARHGEF1
●
1.5
Boersma Breast : all
P−value:0.53; Pearson R:−0.065
1.2
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●●
●● ●
●
● ●●
●
1
●
●
● ● ●
−1.2
−0.8
2
●
●● ● ● ● ●
●● ● ●
●
● ● ●
●
●
●
● ●
●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
●
● ●
● ● ●
● ●● ●● ● ● ● ●● ● ● ● ● ● ●
●
●
●
● ●
−2.0
●
● ● ●
● ● ●
−1.2
●
●
−0.8
−0.4
−1.5
−1.0
2.5
●
●
● ●
●
2.0
4 3
●
●
1
FYN
●
● ● ● ● ●●
●
●
Boersma Breast : all
●
●
●
● ●
●
Boersma Breast : all
● ●
● ●
●●
BCL6
●
●
●
BCL6
● ● ●●
●
● ● ●● ●
● ● ●● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●
●
−1.6
●
●
● ●
● ●
−0.4
●
● ●
● ●
●
● ● ●
1.5
−1.6
●
●
● ●
●
● ●
●●●
●
●● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ●● ●● ● ● ●●
● ●
● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ●
● ●
● ● ●
●
●
● ●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
P−value:0.37; Pearson R:−0.093
●
●
−1.0
●
●
P−value:0.13; Pearson R:−0.16
●
●
2.0
●
● ● ● ●● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ●
●
●
●
● ● ●● ● ●
●
● ●
●
●● ●●
●
●
●
1.0
● ●
●
2
● ●● ● ●
●
1.5
●
●
0.5
3
●●●● ●
FYN
● ● ●●
1.0
●
MAP2K4
●
●
●
0.5
● ●
MAP2K4
●
P−value:0.0068; Pearson R:0.28
4
●
2.5
Boersma Breast : all
P−value:0.16; Pearson R:−0.14
Boersma Breast : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●●
1.0
●
● ●
●
●
−1.4
●
● ●● ●● ●
●
●
●
●
● ● ●● ●
● ●
● ●
−1.0
−0.6
● ●●
●
● ●
1.6
● ● ●
●
● ● ●● ●
● ●
● ●●
●
● ●
● ●
● ●●
● ●●
●
●
● ●
−1.4
−1.0
−0.6
−0.2
BCL6
BCL6
Boersma Breast : epithelial cancer
Boersma Breast : epithelial cancer
1.5 SRC
●
● ●
● ● ●
●
● ●●
●
● ●
0.5
●
●
●
● ●
●
●
● ● ●
●
●
●
●
●
●
●
−2.0
● ●●
● ●
● ●
● ● ●
● ●
−1.8
−1.6
1.6 1.2
●
●
● ●
●
●
● ● ●
●● ●
●● ● ● ●
0.8
●
●
● ●
●
●
●
●● ●
● ●●
● ● ● ●
●●
● ●●
●
● ●
● ●
●
● ●
●
0.4
2.0
●
1.0
● ● ●
●
−0.2
● ●
−2.2
●
●
●
●
MAPK10
●
●
●
●● ● ● ●
0.5
●
P−value:0.92; Pearson R:−0.014
SRC
●● ●
● ●
P−value:0.18; Pearson R:0.2
1.5
●
●
● ●
−2.2
ZBTB7A
−2.0
−1.8
ZBTB7A
Biology Open | Supplementary Material
−1.6
P−value:0.086; Pearson R:−0.25
●
●
1.2
●
0.8
●
● ●
0.4
●
MAPK10
2.0
●
Boersma Breast : epithelial cancer
P−value:0.41; Pearson R:0.12
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
2.2
● ● ●●
● ●
●
●
● ● ●
●
● ● ●
●
●
● ●
● ●
● ●
●
● ● ● ●●●
●
●
●●
●
−1.4
−1.0
−0.6
●
●
0.2
● ●
● ●
●
●
●
●
● ● ●● ● ●
●
●
● ● ● ● ●
●● ● ●
●
●
● ● ●
●
●
−1.4
−1.0
−0.6
−0.2
Boersma Breast : epithelial cancer
Boersma Breast : epithelial cancer
● ●
●●
●
●● ●
●
1.8
●
●
● ●
● ●
●
● ●
●
●
● ●
●
● ●
●
●
●
● ● ●
●
●
1.4
●
●
−2.0
−1.8
−1.6
0.2
●
● ● ●
●
●
●
● ● ●
−0.2 0.0
●
●
●
●
●
● ● ●
●
●
● ●
●
● ● ●
●● ●
●
● ●●
● ● ●
● ● ●
● ●
●
●●
● ●
●
●
●
● ● ●
−0.6
2.6 ●
0.4
BCL6
●
2.2
●
●
BCL6
●
LLGL1
●●
● ●
●
−0.2
●
−2.2
●
●
MAPK8
1.4
●
P−value:0.29; Pearson R:−0.16
1.8
LLGL1
●
●
●
●
−2.2
ZBTB7A
−2.0
● ●
−1.8
ZBTB7A
Biology Open | Supplementary Material
P−value:2.5e−05; Pearson R:0.57
●
●
●
●
● ●
−1.6
P−value:1; Pearson R:6e−04
●
−0.2 0.0
●
●
●
−0.6
2.6
●
MAPK8
● ● ●
0.4
Boersma Breast : epithelial cancer
P−value:1.8e−07; Pearson R:0.67
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ●
●
● ●
●
●
●
●●
● ●
●
●
●
● ●●
●
● ●
●
●
● ●
●
● ● ● ● ● ●
●
−1.8
●
●
●
−1.4
−1.0
−0.6
−1.6 ● ● ● ●
−1.4
● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●
● ●
● ●
−1.0
−0.6
−0.2
Boersma Breast : epithelial cancer
Boersma Breast : epithelial cancer
● ● ●
●
●
● ●●
● ● ● ●● ● ● ● ● ● ●● ● ●
●●
● ●
● ● ●●
●
● ●
● ●
−1.8
●
●
● ●
●
●
−2.0
●
−1.8
−1.6
−1.6
● ● ●
−2.0
●
●
●
● ● ● ● ● ●
● ● ● ●●
● ●
●
●●
● ●● ●●
●
−2.4
●
●
DLG2
−1.0
● ●
−1.4
●●
BCL6
●
MAP2K7
● ●
●
BCL6
●
−2.2
● ●
−0.2
P−value:0.054; Pearson R:−0.28
−1.4
MAP2K7
●
●
●
ZBTB7A
−2.0
●
●●
● ●● ●
−1.8
ZBTB7A
Biology Open | Supplementary Material
● ●● ●● ●
● ● ●
−2.2
●
●●
−1.6
P−value:0.99; Pearson R:−0.0021
●
● ●
−2.0
●
−2.4
● ●
●
DLG2
−1.0
●
P−value:2.3e−06; Pearson R:0.62
Boersma Breast : epithelial cancer
P−value:0.0023; Pearson R:0.43
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●● ● ● ●
●
● ● ●
● ●
●
● ●
−1.4
−1.0
−0.6
1.5
2.0
●
● ●
● ●
●
●
● ● ●
●
● ● ● ●●
●
●
● ●
●
−1.4
−1.0
−0.6
−0.2
●
●
●
●
● ●● ●● ●
●
● ●
● ● ●
−2.0
−1.8
−1.6
2.0
●
●
1.5
● ● ●
●
1.0
● ●● ● ● ● ●
●
●●
● ●
● ●
●
●
● ●
●
−2.0
●
● ●
●
● ●
● ●
● ● ● ●
●
−1.8
ZBTB7A
Biology Open | Supplementary Material
●
●
●
ZBTB7A
● ●
● ●●
−2.2
● ●
●
● ●
0.5
●
●
●
● ●
●
0.0
●
●
●●
●
●
● ●
● ●
●
● ● ●
YES1
0.6 0.2
●
2.5
Boersma Breast : epithelial cancer
● ●
−0.2
●
●
●
●
Boersma Breast : epithelial cancer
● ●
−0.6
● ●
BCL6
●
ARHGEF12
●
●● ●
BCL6
●
−2.2
●
●
● ● ● ●
−0.2
●
●
● ●
●
●
P−value:0.031; Pearson R:−0.31
−0.6
●
● ●
●
● ●
●
●
●
●
●
●
● ●
●
●
● ●
●
−1.6
P−value:0.61; Pearson R:0.076
● ●●●
●
●
●
●
1.0
● ●
●
●
●
●
0.5
●
P−value:0.24; Pearson R:0.17
0.2
●
−0.2
ARHGEF12
●
●
● ●
0.0
●
YES1
0.6
●
2.5
Boersma Breast : epithelial cancer
P−value:0.11; Pearson R:0.24
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●
● ●
●
●●
●
● ●
●
● ● ● ●
●
● ●
● ●
● ●● ●
● ●
● ●
−1.0
−0.6
● ●● ● ● ●●
●
● ●
●
●
● ●
●
●
●
●
●
● ●
●
● ●
●
●
●●
●
● ●
●
−1.4
●
●
−1.0
−0.6
−0.2
BCL6
BCL6
Boersma Breast : epithelial cancer
Boersma Breast : epithelial cancer
●
● ●
● ● ● ● ●
●
●
●
●
● ●
● ● ● ● ●
●
● ● ● ●● ●
● ● ●
● ●
● ●● ● ● ●
●●
●
● ● ● ●
−2.0
−1.8
−1.6
1.0 0.5
●
●
● ●
● ●
●
● ●
0.0
●
−2.2
1.0
−0.2
●
●
● ●
●
●
●
●
●
●
● ●● ●●
●● ●
●
●●
●
−2.2
ZBTB7A
−2.0
●
●
● ●
−0.5
0.0 0.5 1.0 1.5 2.0 2.5
SCRIB
−1.4
● ●
●
DLG3
●
●
● ●
●
●
● ●
●
●
●●
●
● ●
●
●
●
●
●
●
●
−1.8
ZBTB7A
Biology Open | Supplementary Material
●
● ● ● ●●
P−value:0.19; Pearson R:0.19
●
●
●● ●
●
−1.6
P−value:0.29; Pearson R:−0.16
● ●●
● ● ●
0.5
●
0.0
●
−0.5
●
●
DLG3
●
P−value:0.69; Pearson R:0.058
Boersma Breast : epithelial cancer
P−value:0.35; Pearson R:0.14
0.0 0.5 1.0 1.5 2.0 2.5
SCRIB
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
●
● ● ●
−1.4
●
−1.0
−0.6
● ●
● ●
●
●
●
●
●
●
● ●
●
●
●
●
●
●
● ●
●
● ●
●
●
●
●
●
● ●
●
● ●
●
●
●
●
● ●
● ●
●
−1.4
−1.0
−0.6
−0.2
Boersma Breast : epithelial cancer
Boersma Breast : epithelial cancer
−1.4
BCL6
●
−1.6
● ● ● ●
●
●
●
●
●
● ●
●
●
● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●
●
●
−2.0
● ●
● ●
●
●
●
−2.2
●
●
●
●
● ●
−2.2
● ●
BCL6
●
−1.8
−0.2
●
−2.0
−1.8
−1.6
−2.2 −2.0 −1.8 −1.6 −1.4
−2.2
●
●
●
●
●
●
●
● ●
● ●● ● ●● ● ● ● ●●● ● ● ● ● ●
● ●
● ● ●
●
●
●
●
● ●
● ● ● ● ●
● ●
●
● ●
● ●
● ●
● ●
●
● ●
● ● ● ●
●
●
● ●
●
● ● ●
● ●
● ● ● ●
●
●
−2.2
ZBTB7A
−2.0
−1.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.59; Pearson R:0.08
●
●
DLG4
−1.8
● ●
−2.0
DLG1
● ●
●
−1.6
P−value:0.025; Pearson R:0.32
● ●
−2.2 −2.0 −1.8 −1.6 −1.4
●
P−value:0.86; Pearson R:−0.027
−1.6
●
DLG4
●
●
DLG1
Boersma Breast : epithelial cancer
P−value:0.049; Pearson R:0.29
−1.4
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
● ●
●●
●
●
● ●
● ● ●
●● ●
● ●
● ●
−0.6
1.0
● ●
● ●●
−0.2
●● ●
●
●
●
● ●
●
●
●
● ●●
●
● ● ●●
● ●
● ●
●
●
●
●
● ● ●
●
●
●
● ● ●
−1.4
−1.0
−0.6
−0.2
BCL6
BCL6
Boersma Breast : epithelial cancer
Boersma Breast : epithelial cancer
●
●
●●
●
● ● ● ●
● ● ● ●
●
● ● ● ● ●
● ● ●
●
● ● ● ●
● ●
●
●
●
● ●
●
●
●
● ● ● ● ● ●
−2.0
−1.8
−1.6
1.0
● ●●
● ●
0.0
● ● ●
● ● ●
●
●
●
● ● ●● ●
● ●
●
● ●
−1.0
●
●
● ●
● ● ● ● ● ●● ● ●
●
●
●
●
● ●
● ● ●
●
●
●
●
●
−2.0
●
−2.2
●
●
LLGL2
0.2 0.4 0.6 0.8
−1.0
−0.2
MAPK9
−1.4
P−value:0.031; Pearson R:−0.31
−0.2
● ●
●
●
●
−2.2
ZBTB7A
−2.0
−1.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.78; Pearson R:0.041
●
●
● ●
−1.6
P−value:0.31; Pearson R:−0.15
●
●● ●
● ●●
●
0.0
●
●
−1.0
●
●
−2.0
●
●
●
● ● ●
● ●
●
LLGL2
● ●
P−value:2e−04; Pearson R:0.51
Boersma Breast : epithelial cancer
●
0.2 0.4 0.6 0.8
MAPK9
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●
●
●
●
● ●●
● ●
●●
●
●
●
● ●
● ●
●
● ●
●
●
●●
0.0
● ●●
−1.4
●
−1.0
−0.6
1.0
●
● ●
●
●
●
●●
●
●
●
●
●
● ●
●
● ● ● ●
●
●
●
●
●
●
● ●
●
● ●
● ●●
● ●
●
−1.4
−1.0
−0.6
−0.2
Boersma Breast : epithelial cancer
0.4
● ● ● ●
●
●
●
●
● ●● ● ●
● ●
● ●
●
●
●
● ● ●
● ●
−2.0
−1.8
−1.6
1.0
● ●
0.5
● ●●
●
●
●
●
● ● ●
●
● ●
0.0
●● ●
●
●
●
−0.5
0.8
● ●
● ●
●
●
●
● ●
1.5
Boersma Breast : epithelial cancer
1.2
BCL6
● ● ●
0.0
●
●
●
BCL6
●
ARHGEF11
●
● ●
−0.2
●
−2.2
● ●
● ● ●
●● ●
●
●
● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
● ●
●
●● ●
●
●
−2.2
ZBTB7A
−2.0
−1.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.97; Pearson R:−0.0052
●
●
●
●
−1.6
P−value:0.56; Pearson R:−0.086
●
0.5
● ●
ARHGEF1
● ●
●
● ●
●
0.0
●
●
−0.5
●
P−value:0.68; Pearson R:−0.06
0.8
●
0.4
ARHGEF11
●
ARHGEF1
●
1.5
Boersma Breast : epithelial cancer
P−value:0.15; Pearson R:−0.21
1.2
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
● ● ●
●
● ●
●
2
●
●● ●
●
●
●
●
●
●
● ● ●
● ●●
●
1
●
● ● ●
−1.4
−1.0
−0.6
2.5
● ● ●
● ● ●
●
●
●
● ●●
●● ● ●● ● ●
●
● ●
● ●
●
●
● ● ●
●
●
● ●
●
−1.4
−1.0
−0.6
−0.2
Boersma Breast : epithelial cancer
●
●
●
● ●
●
●
●● ●
●
●
● ●
●
● ● ●
● ●
●
●
●
●
●
● ●
● ●
1
●
●
●
● ● ●
−2.0
−1.8
−1.6
●
2.0
● ● ●
●
● ●
1.5
● ●
●
●
●
●
●
●
●
●● ●
●
● ●
● ●
●
1.0
4
●
● ●
2.5
Boersma Breast : epithelial cancer
●
3
● ● ● ●
BCL6
●
2
●
BCL6
●
FYN
●
●
−0.2
●
−2.2
● ●
●●
●
● ●
●
●
● ● ●
● ●
●
●
●
−2.2
ZBTB7A
−2.0
● ● ●
−1.8
ZBTB7A
Biology Open | Supplementary Material
●
●
● ● ●
●
●
● ●
● ●
0.5
FYN
●
●
●●
●
P−value:0.24; Pearson R:−0.17
● ●
MAP2K4
3
●
−1.6
P−value:0.61; Pearson R:0.075
●
●
●
2.0
●
● ●
1.5
●
●
1.0
●
●
●
0.5
●
MAP2K4
●
P−value:0.54; Pearson R:−0.091
Boersma Breast : epithelial cancer
P−value:0.83; Pearson R:−0.033
4
Boersma Breast : epithelial cancer
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●
● ●
● ●
●
●
● ●
●● ●●
●
●
●● ●
●
●
● ●
●
● ●
−1.4
−1.2
−1.0
−0.8
1.6
●
●
●●
−1.4
−1.2
−1.0
−0.8
● ● ●
● ● ●
●
●
●
● ●
● ● ●
● ●
● ●
● ●
●
●
−1.2
●
−1.0
−0.8
−0.6
●
1.6
● ●
●
●
●
●
1.2
●●
● ●
●
−1.4
●
●
●
●
●
● ● ● ● ●
●
●
● ●
●●●●
●
0.8
●
● ● ●
●
●●
●
●
● ●
●
● ● ●
● ●●
●
●
●
●
●
●
●
● ●
● ●
● ● ● ●
0.4
1.2 1.0 0.8 0.6
SRC
● ●
●
● ●
●
Boersma Breast : normal
●
●
● ●
Boersma Breast : normal
●
●
● ●
● ●
BCL6
●
● ●
● ● ●
BCL6
●
●
● ●
●
● ●
●
●●
● ●
−0.6
●
●
● ●
●
●
MAPK10
0.6
●
●
1.2
●
● ●
●
−1.4
ZBTB7A
●
● ●
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.81; Pearson R:−0.036
●
●
●
●
●
0.8
●
●
0.4
●
● ●
●
● ●
MAPK10
●
●
●
P−value:0.78; Pearson R:−0.042
1.0
●
●
0.8
SRC
1.2
●
P−value:0.16; Pearson R:0.21
Boersma Breast : normal
P−value:0.034; Pearson R:0.31
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●
●
●
● ●
−1.4
●
● ●
● ●
●
● ●
●
●
●
−1.2
−1.0
−0.8
0.4 ●
●
● ● ● ●●
● ●
●
●●
● ●
●
● ●
●
−1.4
−1.2
−1.0
−0.8
● ● ●● ● ● ● ●
●
●
●
●● ●
● ● ●
● ●● ● ●
● ●
● ● ●
−1.2
−1.0
−0.8
−0.6
0.4
● ● ● ●
●
●
0.0
●● ● ●
●
●
● ●
●
● ● ●
●
●
●
●
● ● ● ●
−0.4
3.0 2.5
●
●
●
−1.4
●
● ● ● ●
● ●
●
● ●
● ●
●
●
●● ● ● ●
●
●
●
●
●
● ●
● ●
●
●
−0.8
● ●
● ●
●
Boersma Breast : normal
●
●
●
●
●
Boersma Breast : normal
●
●
●
BCL6
●
●
●
BCL6
●
● ●● ●
●
●
●
−0.6
●
●
●
●
MAPK8
● ● ●
●
●
P−value:0.82; Pearson R:0.034
2.0
● ● ●
2.0
●● ●● ●●
●
●
●
●
●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.15; Pearson R:0.21
●
●
●
●
●
LLGL1
●
● ●
●
0.0
●
●
−0.4
●
2.5
LLGL1
●
●
−0.8
●
●
●
MAPK8
3.0
●
P−value:0.00031; Pearson R:0.5
Boersma Breast : normal
P−value:6.2e−06; Pearson R:0.61
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●●
● ●
● ● ●
●
● ●
●●
●●
● ●
● ● ●
●
●
●●
●
● ●
●
●
● ●
−1.8
● ●
−1.0
−0.8
●
−2.0
● ●
●
●
●
● ● ●
●
●
●
●
●
●
●
−1.4
−1.2
−1.0
−0.8
● ●
● ●
●● ●●
●
●
● ● ●● ●
●
● ●
●● ●
● ●
−1.2
−1.0
−0.8
−2.0
●
● ●
●
−2.2
●
●
●
●
● ● ● ● ●
●
● ●
●●
●
●● ●
● ● ●
● ●
● ●
●
●
●
●
●● ●
●
●
●
●
● ●
●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.6
●
● ●
●
−2.4
●
● ●●
●
−2.6
●
−1.4
●
●
●
●
● ●
● ●
●
DLG2
●●
P−value:0.15; Pearson R:0.21
●
● ●
●
● ●
●
Boersma Breast : normal
●
●
● ●
●
Boersma Breast : normal
●
● ●
● ●
●
BCL6
●
●
●
BCL6
●
●
●
● ●
−0.6
●
−1.6
−1.4
−1.2
●
●
−1.8
MAP2K7
−1.2
−1.0
−1.4
●
●
●
−0.8
P−value:0.00019; Pearson R:0.52
●
●
●●
●
P−value:0.17; Pearson R:0.2
● ●
●
●
−2.2
●
−2.4
●
●
●
−2.6
●
●
DLG2
●
−1.2 −1.4
●
●
−1.6
MAP2K7
Boersma Breast : normal
P−value:0.59; Pearson R:0.08
−1.0
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
● ●
●● ● ●
●
● ●
● ●
●
●
●
●
● ● ●
● ●
●
●
−0.2
● ●
−1.4
−1.2
−1.0
−0.8
●
●
●
●
● ● ● ●●
● ●●
● ● ● ●
● ● ● ●
●
● ●
−1.2
−1.0
−0.8
●
●
2.5
● ●
● ● ●
2.0
−1.4
● ●
−1.2
−1.0
−0.8
−0.6
2.5
● ●
●
2.0
● ●
● ●
1.5
●
●
●
●
● ●
● ●
● ●
●
●
●
●
●
●
● ● ● ● ● ● ●●
1.0
●
●
● ●
●
●
● ●
● ●
●
● ●
● ●
0.5
0.2 0.4 0.6 0.8
● ●
●● ● ●
●
● ● ●●
●
−0.2
ARHGEF12
●
●
−1.4
● ●● ●
●
Boersma Breast : normal
● ●
●
●
●
●
● ●● ●
Boersma Breast : normal
● ●
● ●
● ●
BCL6
●
●
● ●
BCL6
●
●
●
●
● ●
−0.6
● ●
●
●
YES1
●
●
●
●
● ●●
●
●
●
●
● ●
● ●
−1.4
ZBTB7A
●
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.93; Pearson R:−0.013
●
●
●
1.5
●
● ●
●
●
1.0
● ●
●
0.5
●
●
YES1
● ●
P−value:0.89; Pearson R:0.021
0.2 0.4 0.6 0.8
ARHGEF12
● ●
P−value:0.013; Pearson R:−0.36
Boersma Breast : normal
P−value:0.068; Pearson R:0.27
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ●
●● ● ● ●
● ●
● ●
● ●
−0.5
●
●
−1.4
−1.2
−1.0
−0.8
0.5
● ● ●
●
● ●
● ● ● ● ● ● ●
● ● ● ● ●●
● ●
●●
●
●
●
●
●
●
●
● ● ●
●
−1.2
−1.0
−0.8
●
● ●
●● ● ●●
●
● ●
−1.4
−1.2
−1.0
−0.8
−0.6
●
0.5
1.5 1.0 0.5 0.0 −0.5
SCRIB
●
●
●
0.0
●
●
●
−1.4
● ● ●
● ●
●●
Boersma Breast : normal
●
● ●
● ● ● ● ● ●
●
● ●
Boersma Breast : normal
● ●
● ●
● ● ●
●
● ● ●
BCL6
●
●
●
BCL6
●
● ●
●
●
●●
−0.6
●
●
●
● ●
● ●
●
●
● ● ● ●
●●
● ● ● ● ● ● ● ●
●
● ●
●
●
−0.5
0.0
●
● ●
●
●
●
DLG3
0.5
●
● ●
● ●
●
●
● ●
● ●
●
● ● ● ● ●
● ● ● ●
●
●
●
● ● ●
●●
● ● ●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.16; Pearson R:−0.21
1.0
●
● ●
●
0.0
●
P−value:0.29; Pearson R:0.16
1.5
●
●
SCRIB
●
●
−0.5
●
●
DLG3
●
P−value:0.46; Pearson R:0.11
Boersma Breast : normal
P−value:0.53; Pearson R:−0.094
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●●
● ●●
● ●
● ●
● ●
● ● ●● ●
●
●
●
●
●
●
●
● ●
● ●
−1.4
−1.2
−1.0
−0.8
● ● ● ●
● ●
●
●
●
●
●
−1.4
−1.2
−1.0
−0.8
●
●
●
● ● ● ●
● ●
●
● ● ● ● ●
● ● ●
● ●
●
●
●
−1.2
−1.0
−0.8
−1.2
−0.6
●
●
●
● ●
−1.4
● ● ● ● ●
−1.6
●● ●
●
−1.4
● ●
●
●
●
● ●
●
● ●
●
●●
● ● ●
●
●
● ●
● ●●
●
●
−1.8
−1.6 −1.8 −2.0 −2.2
DLG1
●●
●
●
●
Boersma Breast : normal
●
● ●
●
●●
Boersma Breast : normal
●● ●
●
●
BCL6
●
●●
●
● ● ●
●
● ●
● ●
● ●
●
● ●●
●
BCL6
●
● ●
●
−0.6
●
● ●
●
●
DLG4
−2.2
●
●
● ●
●
● ●
P−value:0.28; Pearson R:−0.16
●
●
● ●
●
● ● ●
●
●
●
● ●
●
● ● ●
● ●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.59; Pearson R:−0.081
●
●
● ●
P−value:0.65; Pearson R:0.069
● ●
●
−1.4
●
●
−1.6
−1.8 −2.0
DLG1
●
●
●
−1.8
●
DLG4
−1.6
●
−1.2
Boersma Breast : normal
P−value:0.0029; Pearson R:0.43
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ● ●
● ●
● ● ●
●
●● ● ● ● ● ●
●
● ●
● ● ●
●
● ●
●
−1.2
−1.0
−0.8
● ●
●
●
● ● ●
● ●
●
● ●
●
●● ●
● ●
−0.4
● ●
● ●
● ●
−1.4
0.0
●
● ● ● ●
●
●
●
●
●
−1.2
−1.0
−0.8
● ● ●
●
● ●
●
−1.4
−1.2
−1.0
−0.8
−0.6
0.0
●
● ●● ●
● ● ●
● ●
●
● ●
−1.0
●
●
● ●● ●
●
●
● ● ●●
●
●
●
●
●
●
●
●
● ●
● ●
● ●
●
●
●
● ●
● ●
● ●●
−2.0
0.4
●
●
●
●
●
● ● ●
Boersma Breast : normal
●
●
●
●
Boersma Breast : normal
●
●
● ●
BCL6
● ●
●
● ●
● ●
BCL6
●
●●
● ●
−0.6
●
●
● ●
●
LLGL2
0.8
−1.4
P−value:0.29; Pearson R:−0.16
−0.4
●
●
● ●
●
● ●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.25; Pearson R:−0.17
●
0.0
● ●
●
● ●
●
● ● ●
P−value:0.13; Pearson R:−0.22
● ● ●
● ●
●
−1.0
●
● ●
●
●
MAPK9
●
● ●
0.0
MAPK9
0.4
●
−2.0
●
●
●
LLGL2
●
P−value:0.00079; Pearson R:0.47
Boersma Breast : normal
0.8
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
●
●
●
● ●
●
●
● ●
●
● ●
●
●
● ●
●
●
●
●
●
● ●
0.4
●
● ●
● ● ●
●
●
● ● ●
●
●
●
● ● ●
● ● ●● ● ●
●
●
●
●
● ●
●
● ●
−1.4
●
●
●
●
●
−1.2
−1.0
−0.8
●
● ●
−1.4
−1.2
−1.0
−0.8
Boersma Breast : normal
●
●●
● ●
●●
Boersma Breast : normal
●
●
● ●
●
●
BCL6
●
●
●
BCL6
●
●
●
●
● ●
●● ● ● ● ● ●● ● ● ●
●
−0.6
−0.6
●
●
1.0
0.8 0.6
−0.8
●
● ●
0.2
−1.0
0.0
ARHGEF11
−1.2
● ●
● ● ●
●
●
● ●
●
●
● ● ●
● ● ●
●
●
● ● ● ●● ● ●
●
●
● ● ● ●
●
●
● ●
0.5
1.0
−1.4
●
0.0
0.0
●
●
●
ARHGEF1
●
● ●
● ●
P−value:0.12; Pearson R:−0.23
0.4
● ●
● ●
●
●
● ●
●
● ● ●
● ●● ● ●● ● ● ●
●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.58; Pearson R:−0.082
●
● ●
1.0
● ●
●
●
●
●
P−value:0.57; Pearson R:0.085
0.6
●
0.5
●
0.0
●
●
ARHGEF1
0.8
●
0.2
ARHGEF11
Boersma Breast : normal
P−value:0.56; Pearson R:−0.088
1.0
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ●● ●
●
●
● ●
●
● ●
●
●
●
● ●
●
●
●
●
●
● ●
●
●
−1.2
−1.0
−0.8
● ●
● ●
●
● ● ● ● ● ●
●
● ● ●
● ● ● ●
● ●
●
●
−1.2
−1.0
−0.8
●
● ●
2.0
●
● ●●
●
●
●
● ●
−1.4
−1.2
−1.0
−0.8
−0.6
●
2.0
●
●
●
−1.4
●
●
●
1.5
● ● ●
●
● ●
●
● ●● ● ● ●
● ●
1.0
●
● ●
●
● ●
●
● ●●
●
●
●
Boersma Breast : normal
●
●
●
● ●
●
● ●
Boersma Breast : normal
●
●
●
● ●
● ● ●
● ●
● ●
● ●
●
● ● ● ● ●
● ● ●
●
●
● ●●
● ●
●
●
● ●
●
●●
● ●
●
● ●
●
0.5
●
● ● ●
BCL6
●
●
●
●
BCL6
● ●
● ●●
−0.6
● ●
● ●
●
●
−1.4
ZBTB7A
−1.2
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.15; Pearson R:−0.21
●
P−value:0.81; Pearson R:−0.037
● ●
●
1.5
●
1.0
● ●
●●●
●
0.5
●
●
●
● ●
MAP2K4
1.0 1.5 2.0 2.5 3.0 3.5
●
●
MAP2K4
●
P−value:0.86; Pearson R:0.026
●
−1.4
FYN
Boersma Breast : normal
P−value:0.11; Pearson R:0.24
1.0 1.5 2.0 2.5 3.0 3.5
FYN
Boersma Breast : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
●●
●
●
● ●
●
●
●
●
●
−0.7
●
●
2.0
2.5
3.0
3.5
●
● ● ●
●
● ● ●
●
● ● ●
●
● ●
● ● ●
●
●
2.0
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
Collisson Pancreas : all−adenocarcinoma
−0.3
● ●
●
●
●
● ●
● ●
● ● ● ●
●
● ●
●
● ●
−0.7
●
●
−0.4
−0.2
0.0
0.1
0.2
●
2.4 2.6 2.8 3.0 3.2 3.4
●
●
●
FYN
−0.1
●
P−value:0.96; Pearson R:−0.0093
BCL6
●
−0.5
●
● ●
BCL6
●
MAPK8
●
● ●
● ●●
●
●
●
●
● ● ●
● ●
● ●
●● ●
● ●
●
●
● ● ●
● ●
−0.4
ZBTB7A
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
0.1
0.2
P−value:0.082; Pearson R:0.34
●
● ● ● ●
2.4 2.6 2.8 3.0 3.2 3.4
●
●
●
FYN
−0.3
●
−0.5
MAPK8
−0.1
● ●
P−value:0.27; Pearson R:0.22
Collisson Pancreas : all−adenocarcinoma
P−value:0.27; Pearson R:−0.22
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
● ●●
●
●
● ●
●
●
−0.5
● ●
2.0
2.5
3.0
1.0 0.8
● ●
●
●
●●
●
● ●
● ●
●
3.5
●
●
●
●
● ● ● ● ●
● ●
2.0
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
●
−0.3
● ●
●
● ●
●
● ● ●
●
●
● ●
−0.5
●
●
●
● ●
−0.4
−0.2
0.0
0.1
0.2
0.8
●
●
0.6
● ● ●
● ●
●
0.4
●
● ●
●
●
●
●● ●
● ● ● ●
0.2
●
●
●
●
●
●
●
●
0.0
●
MAP2K7
●
1.0
Collisson Pancreas : all−adenocarcinoma
P−value:0.83; Pearson R:−0.044
BCL6
−0.1 0.0
BCL6
●
●
●
●
−0.4
ZBTB7A
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.14; Pearson R:0.29
●
●
0.1
0.2
P−value:0.63; Pearson R:0.096
●
●
●
0.6
●
●
0.4
●
●
−0.3
DLG2
●
0.2
● ●
●
0.0
●
MAP2K7
●
●
DLG2
Collisson Pancreas : all−adenocarcinoma
P−value:0.36; Pearson R:0.18
−0.1 0.0
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
● ●
●
● ●
●
● ●
3.0
● ●
● ●
2.0
2.5
3.0
●
●
0.4
● ●
● ●
●
● ●
●●
● ●●
●
● ●
●
●
2.0
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
Collisson Pancreas : all−adenocarcinoma
4.0
● ●
●
●
●● ●
●
●
● ●●
3.5
● ●
●●
● ● ●
● ●
−0.4
−0.2
0.0
0.1
0.2
0.4
●
● ●
●
● ● ●
0.2
●
●
● ●
● ●
●
0.0
●
●
● ●
●
●
●
● ●
●
●
●
●
●
−0.2
4.5
●
MAPK9
●
0.6
BCL6
5.0
BCL6
●
3.0
●
3.5
●
SCRIB
● ●
P−value:0.2; Pearson R:0.25
● ●
● ●
●
−0.4
ZBTB7A
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
0.1
0.2
P−value:0.79; Pearson R:0.055
●
●
P−value:0.72; Pearson R:0.073
4.0
● ●
3.5
SCRIB
●
● ●
0.2
●
0.0
4.5
●
●
−0.2
●
MAPK9
●
0.6
Collisson Pancreas : all−adenocarcinoma
P−value:0.56; Pearson R:0.12
5.0
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●●
● ●
● ●
●
● ● ● ●
−0.8
●
2.0
2.5
3.0
0.8 0.6
●
● ● ●
●
●
●
● ●
●
● ● ●
● ●
●
●
●
3.5
●
●
● ●
●
2.0
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
● ● ●● ●
● ● ●
●
● ●
● ● ●
−0.8
● ●
●
●
●
●
−0.4
−0.2
0.0
0.1
0.2
0.6
●
● ●
0.4
●
●
●
●
● ● ● ●
● ●
●
●
●
−0.4
ZBTB7A
● ●
●
●
●
● ●
●
●
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
●
●
● ●
0.2
●
● ●
SRC
−0.2
●
0.8
Collisson Pancreas : all−adenocarcinoma
P−value:0.089; Pearson R:0.33
BCL6
0.0
BCL6
●
−0.4 −0.6
●
● ●
P−value:0.13; Pearson R:0.3
●
●
●
0.1
0.2
P−value:0.043; Pearson R:0.39
●
●
●
0.4
●
0.2
●
SRC
●
P−value:0.62; Pearson R:−0.1
−0.2 −0.4
●
●
●
DLG4
Collisson Pancreas : all−adenocarcinoma
●
●
−0.6
DLG4
0.0
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
●
●
● ●
●
● ●
●
●
2.0
2.5
3.0
−0.7
●
● ● ●
●
●
●
●
2.0
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
● ●
●
● ●
● ●
●●
● ● ●
●
●
●
●
● ●
−0.4
●
−0.2
0.0
0.1
0.2
−0.7
●
● ● ●
−0.9
●
●
●●
●
●
●
●
●
● ●
●
● ●
● ●
● ●
● ●
−1.1
●
● ●
ARHGEF12
0.0 −0.2
●
−0.5
Collisson Pancreas : all−adenocarcinoma
●
−0.4
●
●
● ●
BCL6
●
−0.6
●
● ● ●
BCL6
●
DLG1
● ●
● ● ● ●
3.5
P−value:0.22; Pearson R:0.24
−0.6
● ●
● ●
● ●
●
●
−0.4
ZBTB7A
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.72; Pearson R:0.073
●
●
0.1
0.2
P−value:0.038; Pearson R:0.4
●
● ●
−0.9
●
●
−0.4
●
●
●
●
−1.1
−0.2
DLG1
● ●
ARHGEF12
0.0
●
−0.5
Collisson Pancreas : all−adenocarcinoma
P−value:0.02; Pearson R:0.44
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.0
●
●
●
● ●
●● ●
●
● ●
●
●
●
●
● ●
●
●
2.0
2.5
3.0
● ● ● ●
● ●
● ●
●
● ● ● ●
●
●
●
●
●
2.0
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
Collisson Pancreas : all−adenocarcinoma
●
●
●
0.0
● ●
● ●
●●
●
●
●
●
●
−0.5
●
●
●
●
●
● ●
−0.4
−0.2
●
●
0.0
0.1
0.2
2.8 3.0 3.2 3.4 3.6 3.8
0.5
●
●
ARHGEF1
1.0
BCL6
●
−1.0
●
●
BCL6
●
●
● ●
●
3.5
P−value:0.87; Pearson R:0.033
−1.0
●
●
● ●
● ●
● ●
● ● ●
● ●
●
●
●
● ●
●
● ●
● ●
● ●
● ● ●
−0.4
ZBTB7A
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.92; Pearson R:0.02
●
●
−0.5
DLG3
●
● ●
0.1
0.2
P−value:0.035; Pearson R:0.41
●
2.8 3.0 3.2 3.4 3.6 3.8
●
●
ARHGEF1
0.5
●
●
DLG3
Collisson Pancreas : all−adenocarcinoma
P−value:0.52; Pearson R:0.13
1.0
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
3.4
●
●
● ● ●
●
●
●
● ●
●
●
●
3.0
●
●
2.0
2.5
3.0
●
1.0
●
●
● ●
● ●
●
●
●
●
●
● ● ●
●
●
●
2.0
2.5
3.0
3.5
BCL6
BCL6
Collisson Pancreas : all−adenocarcinoma
Collisson Pancreas : all−adenocarcinoma
3.6
●
● ●
3.4
● ● ● ● ● ●
● ●
●
● ●● ●
●
3.0
●
●
−0.4
−0.2
0.0
0.1
0.2
1.0
●
●
●
●
●
●
0.6
●
●
●
●
●
●
● ●
●
●
0.2
●
●
●
● ●
●
● ●
● ●
● ●
●
●
−0.2
●
●
LLGL2
3.8
●
3.2
●
●
●
3.5
●
LLGL1
●
●
●
−0.4
ZBTB7A
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
0.1
0.2
P−value:0.23; Pearson R:0.24
●
3.2
LLGL1
3.6
●
●
●
0.6
● ●
0.2
●
●
●
●
−0.2
●
●
LLGL2
●
P−value:0.22; Pearson R:0.24
3.8
●
P−value:0.23; Pearson R:−0.24
Collisson Pancreas : all−adenocarcinoma
P−value:0.056; Pearson R:0.37
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●
● ● ●
●
●
●
−0.8
●
● ● ●
2.0
2.5
3.0
0.8 0.6
● ● ●
●
● ● ●
● ● ●
●
● ●
●
●
2.0
2.5
3.0
3.5
BCL6
BCL6
Collisson Pancreas : all−adenocarcinoma
Collisson Pancreas : all−adenocarcinoma
● ● ●
●
● ●
●
●
● ● ●
●
●
−0.8
●
●
●
●
● ●
0.8
●
0.6
●
●
● ●
0.4
● ●
0.2
●
MAP2K4
● ●
P−value:0.62; Pearson R:0.1
−0.4
●
−0.6
●● ● ●
3.5
●
●
●
●
ARHGEF11
●
● ●
●
●
●
●
● ●
● ●
● ● ● ●
● ● ●
● ● ●
●
−0.4
●
−0.2
0.0
0.1
0.2
−0.4
ZBTB7A
−0.2
●
0.0
ZBTB7A
Biology Open | Supplementary Material
0.1
0.2
P−value:0.12; Pearson R:−0.31
●
0.4
●
●
● ●
0.2
● ●
●
0.0
●
● ●
●
0.0
−0.4
●
●
−0.6
ARHGEF11
●
MAP2K4
●
P−value:0.3; Pearson R:−0.21
Collisson Pancreas : all−adenocarcinoma
P−value:0.97; Pearson R:−0.0065
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
●
●
●
−1.0
● ●
●
●
●
●
●
2.0
2.5
3.0
0.6 0.4 0.2
●
●
● ●
● ●
●
●
● ●
●
●
● ●
2.0
●
2.5
3.0
3.5
Collisson Pancreas : all−adenocarcinoma
Collisson Pancreas : all−adenocarcinoma
●
● ● ●
●
● ●● ●
● ●
●
●
● ●
●
● ● ●
●
●
−0.4
−0.2
0.0
0.1
0.2
0.6 0.4
●
0.2
●
●
●
●
● ● ●
● ●
●
● ●
●
0.0
●
●
●
● ●
−0.2
●
●
MAPK10
1.0 0.0
0.5
●
P−value:0.31; Pearson R:−0.2
BCL6
●
−0.5
●
●
3.5
●
●
●
BCL6
−1.0
YES1
● ●●
●
●
●
●
ZBTB7A
● ●
●
−0.4
●
● ●
−0.2
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.68; Pearson R:−0.082
−0.5
●
●
● ● ●●
0.1
0.2
P−value:0.79; Pearson R:−0.053
● ● ●
●
0.0
● ●
●
●
−0.2
0.5
●
●
MAPK10
1.0
●
0.0
YES1
Collisson Pancreas : all−adenocarcinoma
P−value:0.25; Pearson R:−0.23
Collisson Pancreas : all−adenocarcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●●
●
●
● ● ●● ●● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ●●
●
−0.5
0.0
0 −1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 0.0 −1.0
−0.5
ARHGEF11
0.5 0.0 −0.5 −1.0
ARHGEF1
−1
0.5
1.0
−1.0
1.0
−1.5
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.53; Pearson R:−0.072
●
●
●
−2
0.0
● ●
● ●
● ● ● ● ● ● ●● ●● ● ●●●●●● ● ●● ●● ● ● ●● ● ●●● ● ● ●● ●●● ● ●●● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ●
−3
● ● ●● ●
●
−4
●
●
ARHGEF11
●
● ●
P−value:1e−06; Pearson R:−0.52
●
−1.0
ARHGEF1
Gaspar Colon : all
●
0.5
1.0
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
●
●
● ●●
●
● ● ● ● ● ● ● ● ●
● ● ●
●
● ●
● ●
● ● ●●● ● ● ● ●●● ● ●● ● ●● ● ● ● ● ● ● ● ●● ● ● ●
−1.0
●
●
● ●
●
●
●
●
−0.5
0.0
●
● ● ●
● ●
● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ●●● ● ●● ●● ●● ●● ● ● ● ● ● ● ● ● ● ● ● ●
●
0.5
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
DLG1
0.5 0.0 −0.5 −1.0
ARHGEF12
●●
1.0
−1.0
●
●
1.0
−1.5
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.51; Pearson R:−0.075
●
2.5
●
● ●
1.5
−0.2
● ●
●
0.5
●
−0.5
●
DLG1
●
●
−0.6
ARHGEF12
●
●
●
Gaspar Colon : all
P−value:0.24; Pearson R:−0.13
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
● ● ●
● ● ●
●
● ● ● ● ●● ● ● ● ● ●● ●● ● ● ●●●●● ● ● ●● ● ● ● ● ● ● ● ● ● ●●
● ●● ● ● ● ● ● ● ●
−1.0
● ●
● ●● ● ● ● ● ●● ● ●
●
●
● ●
−0.5
0.0
0.4
● ●
●
● ●
●
●
● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●
● ●● ● ●
●
●
● ●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
DLG3
0.5 0.0 −0.5 −1.0
DLG2
●
●
0.5
● ● ● ●●
1.0
−1.0
●
●
●
●
1.0
−1.5
0.2
●
●
−0.2 0.0
●
●
−0.6
●
DLG3
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.14; Pearson R:0.17
Gaspar Colon : all
P−value:2.2e−15; Pearson R:−0.75
0.0 0.5 1.0 1.5
DLG2
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data ●
●
●
●
● ●
−0.5 −1.0 1.2
1.4
●
● ●
●
● ● ● ● ● ●●● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ●
●
●
−1.5
−1.0
−0.5
0.0
no data
no data
0.5
0.5 0.0 −0.5 −1.0
−0.5
0.0
FYN
0.5
1.0
BCL6
1.0
●
● ●● ● ●
●
BCL6
−1.0
DLG4
● ● ● ● ●●
●
●●
0.0
FYN
0.0 −0.5 −1.0
DLG4
●
1.0
●
● ● ● ●
0.8
●
● ● ●
●
● ●
0.6
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:1.7e−06; Pearson R:−0.51
0.5
0.5
1.0
1.0
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ● ● ● ●
● ●
●
●
● ●
−0.5
0.0
2 1
● ● ●
0.5
● ●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 LLGL2
0.5
−1.0
−0.5
0.0 −0.5 −1.0
LLGL1
● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●●●● ● ● ● ● ● ● ●● ●● ●● ●● ●● ● ● ●● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ●
1.0
−1.0
●
●
●
●
1.0
−1.5
● ●
●● ●
0.0
−0.5
●
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.036; Pearson R:0.24
●
●
0
0.5
●
●
● ●●
●
−1
● ● ●● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ●
●
0.0
LLGL1
●
−2
●
●
●
●
●
LLGL2
● ●
P−value:4.4e−15; Pearson R:0.75
Gaspar Colon : all
1.0
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●●● ● ●● ● ● ● ●● ● ● ● ●
0.2
● ●
●
●
●
−0.6
●
● ●
−0.5
0.0
● ●
● ● ● ●
●
●
● ●
●
●●
●
●
● ● ● ● ● ● ●
●
● ● ● ●
●
● ●●
● ●
●
●
●
● ● ● ●● ● ●● ●● ● ● ●● ● ● ●● ●
●
●
● ● ●
● ●
0.5
● ●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 MAP2K7
0.5
−1.0
−0.5
0.0 −0.5 −1.0
MAP2K4
●
●
1.0
−1.0
●
●
● ●
1.0
−1.5
●
●
0.0
−0.2
●
0.5
●
● ●
0.0
●
−0.5
● ●
MAP2K4
●
● ●
●
●
−1.0
0.6
● ● ● ● ●
MAP2K7
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.034; Pearson R:−0.24
Gaspar Colon : all
P−value:0.047; Pearson R:0.23
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−2.5
−1.5
●
●
−0.5
0.0
0.2
●
●
● ● ●
● ● ● ●●
● ●
● ●
●
●●
●
●
●
● ● ● ● ● ● ● ●●
●
●
● ●
●
● ● ●● ● ● ● ●● ●
●
●● ●● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●
●
●
● ●
0.5
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
●
0.5
0.5 −1.0
−0.5
0.0
MAPK8
0.5 0.0 −0.5 −1.0
MAPK10
● ●
1.0
−1.0
●
1.0
−1.5
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.06; Pearson R:−0.21
−0.5
●
● ● ●● ●● ● ● ● ● ● ● ●● ●● ● ●● ●● ● ● ● ●● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ● ● ●
−0.2
●●
● ●
−0.6
●
MAPK10
●
● ●
●
MAPK8
●
Gaspar Colon : all
P−value:0.13; Pearson R:−0.17
0.5
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
● ●
●
●
● ●
−0.5
0.0
1.0 0.5 0.6
0.8
1.0
BCL6
BCL6
no data
no data
1.2
1.4
1.2
1.4
0.5 SCRIB
0.5
−1.0
−0.5
0.0 −0.5 −1.0
MAPK9
0.0
0.5
1.0
−1.0
1.0
−1.5
●
−0.5
●
0.0
−0.5
● ●
−1.0
0.5 0.0
MAPK9
●
●
●
● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
SCRIB
● ● ●
P−value:3.2e−13; Pearson R:0.71
Gaspar Colon : all
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
0.0
●
●
● ● ●● ● ●
●
● ●
● ● ●●
● ●
−0.5
● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●
−0.5
0.0
● ●●
●
● ●
●
●
● ●
● ●
● ● ● ●●
●
●
●
0.5
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 YES1
0.5
−1.0
−0.5
0.0 −0.5 −1.0
SRC
●
1.0
−1.0
● ●
1.0
−1.5
● ●
●
●
0.0
SRC
● ●
● ●● ●● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:1.6e−05; Pearson R:0.47
● ●
●
●
0.5
●
● ●● ●
●
0.0
●
●
● ●
−0.5
●
YES1
●
●
0.5
Gaspar Colon : all
P−value:1.7e−10; Pearson R:−0.65
1.0
Gaspar Colon : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ● ●
● ● ●
● ●
●
●● ● ●
● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ●● ● ● ● ● ●●
●
●
−0.5
0.0
0 −1
●
●
●
0.5
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 0.0 −1.0
−0.5
ARHGEF11
0.5 0.0 −0.5 −1.0
ARHGEF1
●
1.0
−1.0
●
1.0
−1.5
● ●
● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ●● ●● ●●● ●●● ●●●● ● ● ● ●● ● ● ●● ● ● ● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.54; Pearson R:−0.084
●
●
−2
0.0
●
●
−3
●
● ●
●
−4
●
●
ARHGEF11
●
P−value:1.1e−05; Pearson R:−0.55
●
−1.0
ARHGEF1
Gaspar Colon : colorectal_adenoma
●
0.5
1.0
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
● ●
●●●
●
●● ●
● ●
●
●
●
●
●
● ●
● ●
● ●
● ●
● ●●
● ●
●
−1.0
● ●
●
●
●
●
−0.5
0.0
2.5
● ●
● ●
● ● ● ● ● ● ●● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ●● ●● ●● ● ● ● ● ● ● ● ● ●
●
● ●
0.5
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
DLG1
0.5 0.0 −0.5 −1.0
ARHGEF12
●
1.0
−1.0
●
●
1.0
−1.5
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.28; Pearson R:−0.15
● ●
●
●
●
1.5
●
● ●
●
0.5
−0.2
●
−0.5
●
DLG1
●
●
−0.6
ARHGEF12
●
●
●
Gaspar Colon : colorectal_adenoma
P−value:0.15; Pearson R:−0.2
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
−1.0
●
● ● ●
●
●
● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
●
●
−0.5
0.0
0.0
● ●
● ●
●
●
● ●●
● ● ●● ● ● ● ●
● ●
●
● ● ●
● ● ●
●
● ●●
●
● ●
0.5
●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
DLG3
0.5 0.0 −0.5 −1.0
DLG2
●
● ● ● ●
1.0
−1.0
● ● ● ●
●
1.0
−1.5
●
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.16; Pearson R:0.19
●
●
●
−0.2
●
●
● ●● ●
−0.4
● ● ●
●
●
−0.6
●
DLG3
●
0.2
Gaspar Colon : colorectal_adenoma
P−value:7.4e−13; Pearson R:−0.79
0.0 0.5 1.0 1.5
DLG2
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data 1.0 0.5
●
●
●
● ●
● ● ●
● ●
−0.5 −1.0 1.0
1.2
1.4
●
●
●
●●● ● ● ● ● ●●
●
● ● ● ● ●● ● ● ● ● ●
●
●
−1.5
−1.0
−0.5
0.0
BCL6
no data
no data
0.5
0.5 0.0 −0.5 −1.0
−0.5
0.0
FYN
0.5
1.0
BCL6
−1.0
DLG4
● ● ● ● ●
●
●
● ● ● ● ● ● ●
●●
0.0
FYN
0.0 −0.5
0.8
1.0
0.6
● ●
●
−1.0
DLG4
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:8.3e−07; Pearson R:−0.6
1.0 0.5
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ● ● ● ●
●
●● ● ●● ●
0.0
● ● ● ●
−0.5
●
● ● ● ●
● ●
●
● ●
−0.5
0.0
● ●
●
● ● ●
●●● ● ● ●● ●● ● ● ●● ●● ● ● ● ●● ● ● ●
● ●
0.5
● ● ●● ● ●
●
● ●
●
●
●
●
●
● ●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 LLGL2
0.5
−1.0
−0.5
0.0 −0.5 −1.0
LLGL1
●
● ●
1.0
−1.0
● ●
●
●
1.0
−1.5
●
0.0
LLGL1
●
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:9e−04; Pearson R:0.43
●
●
● ● ● ● ●● ● ● ● ●● ●
2.0
0.5
●
● ●●
1.0
● ● ●
●
0.0
●
−1.0
●
LLGL2
●
Gaspar Colon : colorectal_adenoma
P−value:2.6e−11; Pearson R:0.75
1.0
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.2
●
●
●
●
●
●
●
−0.6
●
● ●
−0.5
0.0
● ● ●
0.5
● ●
● ●
●
● ● ● ● ●●
●● ● ● ●● ●
●
●
● ● ●● ● ●● ● ● ● ● ● ● ●
● ●
0.5
● ●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 MAP2K7
0.5
−1.0
−0.5
0.0 −0.5 −1.0
MAP2K4
●
●
1.0
−1.0
● ●
● ● ●
1.0
−1.5
●
●
0.0
−0.2
●
●
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.022; Pearson R:−0.31
● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ●
● ●
0.0
●
●
−0.5
● ●
MAP2K4
●
−1.0
0.6
●
MAP2K7
●
Gaspar Colon : colorectal_adenoma
P−value:0.0068; Pearson R:0.36
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●● ● ● ●● ● ●●
● ●● ●● ● ● ● ● ●● ● ●● ● ●● ● ● ● ●● ● ● ● ● ● ●
●
●
−2.5
−1.5
●
●
−0.5
0.0
● ● ● ●
●
●
● ●
●
●
●
●
● ● ●●● ● ●
● ●
●
●
●● ●● ●● ● ● ● ● ● ●● ●● ● ● ●
● ●
0.5
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
MAPK8
0.5 0.0 −0.5 −1.0
MAPK10
● ●
1.0
−1.0
● ●
●
●
●
●
1.0
−1.5
● ● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.44; Pearson R:−0.1
−0.5
●
●●
0.2
● ●
−0.2
● ●
●
−0.6
●●
● ●
MAPK8
●
MAPK10
●
●
●
Gaspar Colon : colorectal_adenoma
P−value:0.15; Pearson R:−0.19
0.5
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
●
●
● ●
● ●
● ●
−0.5
0.0
1.0 0.5 0.6
0.8
1.0
BCL6
BCL6
no data
no data
1.2
1.4
1.2
1.4
0.5 SCRIB
0.5
−1.0
−0.5
0.0 −0.5 −1.0
MAPK9
0.0
0.5
1.0
−1.0
1.0
−1.5
●
0.0
−0.5
●
−0.5
●
−1.0
0.5 0.0
MAPK9
●
●
●
● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ●● ●● ● ● ● ● ●● ● ● ●● ● ● ●
SCRIB
● ● ●
P−value:4.4e−09; Pearson R:0.69
Gaspar Colon : colorectal_adenoma
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●● ●
0.0
SRC
●
●
−0.5
●
●
●
● ● ●
●
● ● ●●
● ● ●● ● ● ● ● ●● ● ●● ●● ●● ●● ● ● ●
● ●
● ● ●
−0.5
0.0
0.6
●●
● ● ● ● ● ● ● ●
●
●
●
●
● ● ●
● ●
●
●
●
●
● ●
●● ●
● ●
●
0.5
●
●
● ●
−1.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 YES1
0.5
−1.0
−0.5
0.0 −0.5 −1.0
SRC
● ● ●
●
●
●
1.0
−1.0
●
●●
●
●
1.0
−1.5
● ● ●
0.2
● ●
●
●
−0.2
● ●
● ●● ●
0.0
0.5
●
● ●
−0.6
●
●
YES1
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.00014; Pearson R:0.49
Gaspar Colon : colorectal_adenoma
P−value:5.3e−08; Pearson R:−0.65
Gaspar Colon : colorectal_adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ● ● ●
●
●
●
● ●
●
−0.5
●
●
●
0.0
0.2
●
0.5
● ●
●
● ●
● ●
● ●● ●
● ● ●
−1.0
●
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 0.0 −1.0
−0.5
ARHGEF11
0.5 0.0 −0.5 −1.0
ARHGEF1
● ● ●
1.0
−0.5
1.0
−1.0
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.9; Pearson R:−0.03
●
●
●
0.0
●
−0.4 −0.2
●
ARHGEF11
●
0.0
ARHGEF1
0.5
●
0.4
Gaspar Colon : normal
P−value:0.016; Pearson R:−0.51
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●● ●
●
●
−0.8
● ●
● ●
●
0.0
1.0
●● ●
●
●
●
● ● ● ● ●
●
0.5
−1.0
●
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
DLG1
0.5 0.0 −0.5 −1.0
ARHGEF12
●
●
1.0
−0.5
●
●
●
1.0
−1.0
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.39; Pearson R:0.19
●
● ●
●
0.5
●
●
0.0
●
●
●
DLG1
● ●
P−value:0.75; Pearson R:0.073
−0.2 −0.4
Gaspar Colon : normal
●
−0.6
ARHGEF12
0.0
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
● ● ●
●
●
0.0
0.2
0.4
● ●
●
●
●
●
●
● ●
● ● ●
0.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
DLG3
0.5 0.0 −0.5 −1.0
DLG2
●
● ●
1.0
−0.5
●
●
1.0
−1.0
●
●
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.49; Pearson R:0.16
● ●
●
−0.5
● ●
●
0.0
0.0
●●
−1.0
DLG2
● ●
●
●
−0.2
● ●
●
DLG3
●
P−value:0.00084; Pearson R:−0.66
Gaspar Colon : normal
0.5
1.0
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data ●
0.8
●
0.5
● ●
0.4
● ● ●
●
0.0 −0.4
●
−0.5
0.0
FYN
●
−1.0
DLG4
● ● ●
●
● ● ● ●
1.0
1.2
1.4
●
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
FYN
0.5 0.0 −0.5 −1.0
DLG4
●
1.0
0.8
1.0
0.6
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.093; Pearson R:−0.37
1.0
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
0.2
● ● ●
●
● ●
● ●
●
●
●
●
0.0
1
0.5
−1.0
−0.5
● ●
● ● ● ●
0.0
BCL6
BCL6
no data
no data
0.5
0.5 LLGL2
0.5
−1.0
−0.5
0.0 −0.5 −1.0
LLGL1
●● ●● ●
1.0
−0.5
● ● ● ●●
●
1.0
−1.0
●
●
0.0
−0.6
−0.2
LLGL1
●
0
● ●
●
●
−1
●
●
−2
0.6
●
LLGL2
●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.69; Pearson R:−0.091
Gaspar Colon : normal
P−value:4.6e−05; Pearson R:0.76
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
0.2
●
● ● ●
●
●
● ● ●
0.0
● ● ● ● ●
0.5
●
0.5
● ●
● ●
●
●
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
MAP2K7
0.5 0.0 −0.5 −1.0
MAP2K4
● ● ● ●
1.0
−0.5
●
●
●
1.0
−1.0
●
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.68; Pearson R:−0.094
0.4
● ●
●
0.0
● ● ●
0.0
MAP2K4
0.6
●
−0.5
●
MAP2K7
●
Gaspar Colon : normal
P−value:0.7; Pearson R:−0.089
0.8
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
● ●●
●
●
●●
●
●
−0.2
● ●
● ●
0.0
●
0.0 −0.2
● ●
●
● ●
●
●
●
● ●
● ●
●
●
0.5
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
MAPK8
0.5 0.0 −0.5 −1.0
MAPK10
●
1.0
−0.5
●
●
1.0
−1.0
●
●
−0.4
●
●
−0.6
0.2
● ●
0.0
MAPK10
●
●
MAPK8
0.4
● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.025; Pearson R:−0.48
Gaspar Colon : normal
P−value:0.65; Pearson R:−0.1
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
●●
● ● ● ●
●
● ●
0.0
1.0
0.5
0.6
1.0
BCL6
BCL6
no data
no data
1.2
1.4
1.2
1.4
0.5 SCRIB
0.5
−1.0
−0.5
0.0 −0.5 −1.0
MAPK9
0.8
1.0
−0.5
1.0
−1.0
0.0
−0.6
●
0.5
●
●
0.0
0.2
●
●
● ●
−0.2
MAPK9
●
−0.5
● ●
−1.0
●
SCRIB
● ●
P−value:3.1e−06; Pearson R:0.82
0.6
Gaspar Colon : normal
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
●
●
−0.5
● ● ● ●
0.0
●
0.4 0.0
● ● ●
● ● ●
0.5
●
●
●
−1.0
−0.5
0.0
BCL6
BCL6
no data
no data
0.5
0.5 −1.0
−0.5
0.0
YES1
0.5 0.0 −0.5 −1.0
SRC
● ●
1.0
−0.5
● ●
1.0
−1.0
● ●
● ● ●
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
1.2
1.4
P−value:0.034; Pearson R:0.45
●
●
−0.4
0.0
●
●
● ●
−0.8
●
● ● ●
●
YES1
SRC
● ●
P−value:0.0016; Pearson R:−0.63
Gaspar Colon : normal
●
0.5
1.0
Gaspar Colon : normal
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
● ● ● ●
●
● ●
−4
−2
0
0.0
● ●
● ●
● ●
●
● ●
●
●
●
−4
−2
0
2
Grutzmann Pancreas : all(no met)
Grutzmann Pancreas : all(no met)
●
●● ● ●● ●
● ● ● ● ●
●
●
−1.5
−1.0
−0.5
0.5 0.0
●
●
●
−0.5
●
−1.0
●
●
●
● ● ●
● ●
●
● ● ●
●
●
−2.0
ZBTB7A
−1.5
●
−1.0
ZBTB7A
Biology Open | Supplementary Material
●
●
●
−1.5
0.5
●
ARHGEF11
1.5 1.0
●
●
P−value:0.85; Pearson R:−0.044
BCL6
●
●
●
BCL6
●
−0.5 0.0
ARHGEF1
●
●
2
●
−2.0
●
● ●
P−value:0.045; Pearson R:−0.43
●
● ●
−0.5
P−value:0.12; Pearson R:0.34
●
●
−0.5
●
●
●
−1.0
0.5
● ●
●
−1.5
●
●
−0.5 0.0
ARHGEF1
1.0
● ●
ARHGEF11
1.5
●
0.5
Grutzmann Pancreas : all(no met)
P−value:0.34; Pearson R:0.21
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●
●
●
●
●
●
● ●
−1.5
●
●
−4
−2
0
0.4
●
●
● ●
●
● ● ●
● ●
−2
●
0
2
● ●
●
● ●
●
●
−1.0
● ●
●
● ●
●
−1.5
−1.0
−0.5
●
0.4
●
● ●
0.0
● ●
● ● ●
●
● ●
●
● ● ●
●
−0.4
●
●
●
DLG1
●
●
0.8
Grutzmann Pancreas : all(no met)
P−value:0.056; Pearson R:0.41
Grutzmann Pancreas : all(no met)
0.5 0.0
●
●
BCL6
●
−0.5
● ●
BCL6
●
−1.5
●
−4
●
ARHGEF12
●
2
●
−2.0
●
● ●
●
●
−2.0
ZBTB7A
−1.5
●
−1.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.9; Pearson R:0.029
●
●
−0.5
P−value:0.013; Pearson R:0.52
−0.5
●
●
●
0.0
● ●
●
●
●
−0.4
0.0
●
−1.0
ARHGEF12
●
DLG1
0.5
●
0.8
Grutzmann Pancreas : all(no met)
P−value:0.2; Pearson R:−0.29
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
●
●
−2.0
● ●
−4
−2
0
1.5
● ●
●
●
●
● ●
●
−2
● ● ●
● ●
●
0
2
BCL6
Grutzmann Pancreas : all(no met)
Grutzmann Pancreas : all(no met)
●
●
●
−1.0
● ●
●
● ●
●
−2.0
●
● ●
−1.5
−1.0
−0.5
1.5
● ● ●
1.0
●
● ●
● ●
0.5
●
●
●
●
0.0
●
●
DLG3
0.0
● ●
●
DLG2
●
●
BCL6
●
−2.0
● ●
−4
●
●
●
2
P−value:0.3; Pearson R:−0.23
−1.0
●
● ●
●
● ●
● ●
●●
● ●
●
−2.0
ZBTB7A
−1.5
−1.0
ZBTB7A
Biology Open | Supplementary Material
●
●
●
−0.5
P−value:0.019; Pearson R:−0.5
●
●
DLG2
●
1.0
●
● ●
●
●
0.5
●
●
0.0
●
DLG3
0.0
● ●
P−value:0.22; Pearson R:0.27
Grutzmann Pancreas : all(no met)
P−value:0.52; Pearson R:0.14
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ●
●
●
●
●
●
−2.5
●
●
−4
−2
●
0
1.5
● ●
●
●
0
2
●
● ●
● ●
●
●
●
−1.5
−1.0
−0.5
1.5 1.0
●
● ● ●
0.5
●● ●
●
●
●
● ●
●
●
0.0
●
●●
●
● ●
●● ●
●
●
●
−0.5
●
●
FYN
●
P−value:0.022; Pearson R:0.49
Grutzmann Pancreas : all(no met)
●
● ●
●
●
−2
●
●● ● ●
Grutzmann Pancreas : all(no met)
−1.0 −1.5
● ●
BCL6
●
−2.0
●
●
BCL6
●
−2.5
●
−4
●
DLG4
● ●
2
●
−2.0
●
●
−2.0
ZBTB7A
−1.5
−1.0
ZBTB7A
Biology Open | Supplementary Material
●
−0.5
P−value:0.76; Pearson R:−0.069
●
●
1.0
●
●
0.5
●
0.0
−1.5
●
●
−0.5
●
−2.0
DLG4
−1.0
●
FYN
●
P−value:0.92; Pearson R:−0.022
Grutzmann Pancreas : all(no met)
P−value:0.089; Pearson R:−0.37
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ● ●
● ●●●
●
●
−1.0
●
●
−4
−2
0
4
●
● ●
● ●
●
●
● ● ●
−4
●
−2
0
2
Grutzmann Pancreas : all(no met)
●
●
●●
●
−2.0
−1.0
●
●
−1.5
−1.0
−0.5
4 3
●
● ●
●
●
●
● ●
● ●
2
● ●
● ●
●
●
● ● ●
●
1
●
● ●
● ●
● ● ● ●
0
●
●
LLGL2
●● ●
P−value:0.97; Pearson R:−0.0097
Grutzmann Pancreas : all(no met)
1.0
BCL6
●
0.0
● ●
BCL6
●
LLGL1
● ● ●
2
●
−2.0
● ●
−2.0
ZBTB7A
−1.5
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.5
P−value:0.51; Pearson R:−0.15
●
3
0.0
●
−2.0
LLGL1
●
● ●
2
●
1
●
0
●
●
●
LLGL2
●
P−value:0.58; Pearson R:0.13
Grutzmann Pancreas : all(no met)
P−value:0.82; Pearson R:−0.051
1.0
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
● ●
●
−3
●
−4
−2
0
● ●
●
●
●
● ●
● ●
●
●
●
−2
●
0
●
2
Grutzmann Pancreas : all(no met)
Grutzmann Pancreas : all(no met)
0
●
● ●
●
−1
●
● ●
−3
●
●
−1.5
−1.0
−0.5
0.0
● ●
● ●
●
●
●
●
−1.0
● ●
●
●
●
● ● ●
●
●
●
●
● ●
●
−2.0
●
MAP2K7
1
●
−2
●
BCL6
●
MAP2K4
●
BCL6
●
−2.0
●
●
−4
●
●
● ●
2
P−value:0.32; Pearson R:−0.22
−2
−1
●
●
●
● ●
−2.0
ZBTB7A
−1.5
●
●
−1.0
ZBTB7A
Biology Open | Supplementary Material
●
−0.5
P−value:0.012; Pearson R:0.52
0
●
●
●
●
0.0
● ● ●
●
−1.0
●
MAP2K4
● ●
−2.0
1
● ●
MAP2K7
●
P−value:0.0024; Pearson R:−0.61
Grutzmann Pancreas : all(no met)
P−value:0.0085; Pearson R:0.55
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
−2.5
●
●
−4
−2
0
●
●
●● ● ● ●
● ● ●
●
● ●
●
● ●
−4
−2
0
2
BCL6
Grutzmann Pancreas : all(no met)
Grutzmann Pancreas : all(no met)
● ●
−1.5
● ●
−2.5
● ●
●
−1.5
−1.0
−0.5
1.5
● ● ●
●
● ● ●
0.5
●
●
● ●●
●
●
● ●
●
● ●
−0.5
● ●
●
MAPK8
● ●
P−value:0.19; Pearson R:−0.29
−0.5
● ●
BCL6
●
MAPK10
●
2
●
−2.0
●
●
●
●●
●
● ●
●
●
● ●
−2.0
ZBTB7A
−1.5
−1.0
ZBTB7A
Biology Open | Supplementary Material
−0.5
P−value:0.011; Pearson R:0.53
●
−1.5
MAPK10
●
1.5
● ●
●
0.5
● ●●
●
−0.5
−0.5
● ● ●●
● ●●
MAPK8
●
● ●
P−value:0.0063; Pearson R:−0.56
Grutzmann Pancreas : all(no met)
P−value:0.29; Pearson R:0.24
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
● ●
0.5
●
●
● ●●
●
−4
−2
0
1
●
● ● ●
−2
0
2
Grutzmann Pancreas : all(no met)
●
● ●
●
● ●
●
●
−1.5
−1.0
−0.5
1
●
0
● ●
●● ●
−1
●
1.0
●
● ●
● ● ●
●
●
● ●
●
● ●
●
−2
1.5
●
●
● ●
●
●
●
−3
2.0
● ●
SCRIB
●
2
Grutzmann Pancreas : all(no met)
P−value:0.47; Pearson R:−0.16
BCL6
●
0.5
● ●● ● ●● ●
●
−4
0.0
MAPK9
●
BCL6
●
−2.0
● ●
●
2
●
●
● ●
●
−2.0
ZBTB7A
−1.5
−1.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.23; Pearson R:0.27
1.0
● ●
−0.5
P−value:0.52; Pearson R:0.15
●
●
●
0
●
●
● ●
−1
1.5
●
●
−2
●
0.0
MAPK9
●
−3
2.0
●
SCRIB
●
2
Grutzmann Pancreas : all(no met)
P−value:0.057; Pearson R:0.41
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
−1.0
● ●
●
−4
−2
●
0
2 0
−2
0
2
Grutzmann Pancreas : all(no met)
● ●
●
●
● ● ●
●
−1.5
−1.0
−0.5
●
●
●
●
●
●
●
2
●● ● ●
●
● ●● ●
0
●
−2
●
●
●
−4
0.0 −0.5
● ● ●
● ●
● ● ●
YES1
0.5
●
4
Grutzmann Pancreas : all(no met)
●
●
●
BCL6
●
−1.0
●
BCL6
●
SRC
●
●
−4
●
−2.0
●●● ●
●
2
●
●
●
● ●
●
−2.0
ZBTB7A
−1.5
−1.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.00084; Pearson R:0.66
●●
● ●
●
●●
−0.5
P−value:0.081; Pearson R:−0.38
●
●
●
−2
●
●
● ●
−4
●
−0.5
SRC
●
●
●
YES1
● ●
0.0
●
P−value:0.00031; Pearson R:0.7
0.5
● ●
4
Grutzmann Pancreas : all(no met)
P−value:0.03; Pearson R:−0.46
Grutzmann Pancreas : all(no met)
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
−4
−2
0
0.0
−2
0
2
BCL6
Grutzmann Pancreas : normal
Grutzmann Pancreas : normal
●
●
● ●
−1.5
−1.0
●
−0.5
0.5 0.0 −0.5
●
●
●
●
−1.0
●
ARHGEF11
0.5
●
●
0.0
● ●
BCL6
●
−0.5
ARHGEF1
●
−4
●
−2.0
●
●
2
P−value:0.44; Pearson R:0.26
−0.5
●
●
●
●
● ●
●
●
●
●
−2.0
ZBTB7A
●
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.037; Pearson R:−0.63
●
●
●
P−value:0.14; Pearson R:0.47
●
●
−0.5
● ●
●
−1.0
●
ARHGEF11
0.5
●
0.0
ARHGEF1
●
0.5
Grutzmann Pancreas : normal
P−value:0.53; Pearson R:0.21
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
−4
−2
0
●
●
2
−4
●
0
2
Grutzmann Pancreas : normal
●
● ●
●
●
●
●
● ● ●
●
●
●
−1.5
−1.0
−0.5
● ●
−0.4
−1.0
●
DLG1
●
P−value:0.5; Pearson R:0.23
0.0
●
0.0 0.2 0.4 0.6
Grutzmann Pancreas : normal
●
−0.5
−2
●
BCL6
●
−1.5
●
BCL6
●
ARHGEF12
●
● ●
●
−2.0
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.23; Pearson R:−0.39
−1.0
●
●
P−value:0.016; Pearson R:0.7
−0.5
● ●
−1.5
ARHGEF12
●
0.0 0.2 0.4 0.6
●
●
●
−0.4
0.0
●
DLG1
Grutzmann Pancreas : normal
P−value:0.049; Pearson R:−0.6
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
1.5
● ● ●
1.0
−1.0
●
−2.0
DLG2
●
●
● ●
0.5
●
0.0
●
DLG3
● ●
●
P−value:0.5; Pearson R:0.23
0.0
● ●
●
−4
−2
●
0
2
−4
2
Grutzmann Pancreas : normal
−2.0
● ●
−1.5
−1.0
−0.5
1.5
● ●
1.0
● ● ●
0.5
●
●
0.0
−1.0
●
●
DLG3
0.0
●
●
P−value:0.44; Pearson R:−0.26
Grutzmann Pancreas : normal
●
DLG2
0
BCL6
● ●
−2.0
−2
BCL6
●
●
●
●
●
●
● ●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.16; Pearson R:0.45
Grutzmann Pancreas : normal
●
P−value:0.065; Pearson R:−0.57
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−2.5
●
●
−4
−2
0
●
●
−4
−2
0
2
Grutzmann Pancreas : normal
●
●
−1.5
−1.0
●
−0.5
0.0 0.2 0.4 0.6
●● ●
●
●
● ● ● ● ● ●
●
−0.4
●
●
FYN
●
P−value:0.023; Pearson R:0.67
Grutzmann Pancreas : normal
−1.0 −1.5
● ●
BCL6
●
−2.0
● ●
BCL6
●
−2.5
DLG4
● ●
2
●
−2.0
●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.61; Pearson R:0.17
●
●
0.0 0.2 0.4 0.6
●
●
−0.4
●
● ●
●
FYN
−1.5
● ●
−2.0
DLG4
−1.0
●
P−value:0.081; Pearson R:−0.55
Grutzmann Pancreas : normal
P−value:0.1; Pearson R:−0.52
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0
3.5 2.5
●
●
−4
−2
0
2
BCL6
BCL6
Grutzmann Pancreas : normal
Grutzmann Pancreas : normal
0.2
● ● ●
●
●
−1.5
−1.0
●
−0.5
3.5 2.5
●
●
●
●
●
●
●
1.5
●
●
●
0.5
●
●
LLGL2
1.0 0.6
●
−2.0
●
2
●
●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.16; Pearson R:0.46
−0.2
−2
●
−0.2
●
●
−4
LLGL1
● ●
●
P−value:0.64; Pearson R:−0.16
● ●
●
●
●
1.5
●
● ●
0.5
●
●
LLGL2
● ●
P−value:0.097; Pearson R:0.53
0.6
1.0
●
0.2
LLGL1
Grutzmann Pancreas : normal
P−value:0.27; Pearson R:−0.36
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
−4
−2
0
●
● ●
● ●
●
−4
−2
0
2
Grutzmann Pancreas : normal
0.0
●
−2.0
−1.0
●
● ●
−1.5
−1.0
−0.5
0.0
●
●
−2.0 −1.5 −1.0 −0.5
●
●
MAP2K7
●
●
P−value:0.22; Pearson R:−0.4
Grutzmann Pancreas : normal
1.0
BCL6
●
MAP2K4
●
BCL6
●
−2.0
●
2
●
●
●
● ●
●
● ●
● ● ●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.0099; Pearson R:−0.74
●
●
P−value:0.097; Pearson R:0.53
0.0 −1.0
●
−2.0
MAP2K4
●
0.0
● ●
●
−2.0 −1.5 −1.0 −0.5
● ● ●
●
MAP2K7
●
P−value:0.004; Pearson R:0.79
Grutzmann Pancreas : normal
1.0
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
−1.5
−1.0
●
1.5
●
●
0.5
●
● ● ● ● ● ●
●
−4
−2
0
2
0
2
Grutzmann Pancreas : normal
Grutzmann Pancreas : normal
−1.0
●
−1.5
●
●
−1.5
−1.0
−0.5
1.5
● ●
●
●
0.5
●
●
●
● ●
● ●
−0.5
●
MAPK8
● ●
●
MAPK10
−2 BCL6
P−value:0.24; Pearson R:−0.39
−0.5
−4
BCL6
●
−2.0
●
●
−0.5
●
MAPK8
●
●
MAPK10
●
P−value:0.11; Pearson R:0.5
−0.5
● ●
● ● ●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.0021; Pearson R:−0.82
Grutzmann Pancreas : normal
P−value:0.086; Pearson R:0.54
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
Grutzmann Pancreas : normal
●
−4
−2
0
1 0 −1
−2
0
2
Grutzmann Pancreas : normal
Grutzmann Pancreas : normal
● ●
●
−1.5
−1.0
−0.5
1 0
●● ●
−1
● ●
●
● ●
−2
1.0
●
●
●
−3
2.0 1.5
●
●
SCRIB
●
P−value:0.73; Pearson R:−0.12
BCL6
●
0.5
●
BCL6
0.0
MAPK9
●
●
−4
●
−2.0
●
2
●
●
● ● ●
P−value:0.5; Pearson R:0.23
0.0
●
● ●
P−value:0.5; Pearson R:0.23
●
●
−2
1.0
● ●
●
−3
●
●
●
0.5
MAPK9
●
SCRIB
●
1.5
2.0
●
P−value:0.015; Pearson R:0.71
Grutzmann Pancreas : normal
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
−4
−2
0
2 0 ●
−4
−2
0
2
Grutzmann Pancreas : normal
●
●
−1.5
−1.0
●
−0.5
●
●
●
2
● ●●
0
●
−2
0.0 −0.5
● ●
●
−4
●
● ●
YES1
0.5
Grutzmann Pancreas : normal
●
−1.0
SRC
●
BCL6
●
−2.0
●
BCL6
●
●
●
2
●
●●
●
−2.0
ZBTB7A
−1.5 ZBTB7A
Biology Open | Supplementary Material
−1.0
P−value:0.00056; Pearson R:0.87
●
●
P−value:0.23; Pearson R:−0.39
●
● ●
●
−2
−0.5
●
−1.0
SRC
0.0
●
● ●
−4
●
●
YES1
●
P−value:0.014; Pearson R:−0.71
Grutzmann Pancreas : normal
P−value:0.0027; Pearson R:0.81
0.5
Grutzmann Pancreas : normal
−0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
−0.5
0.5 0.0
0.5 1.0 1.5 2.0 2.5 3.0
● ● ●
●
●
●
●
●
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
●
−0.5 0.0
● ●
●
−1.6
−1.2
−0.8
−0.4
0.0 −0.5
● ●
● ●
●
−1.0
●
● ●●
●
−1.5
● ●
ARHGEF11
1.5 0.5
1.0
●
●
●
● ●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.39; Pearson R:0.29
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
0.5
BCL6
P−value:0.062; Pearson R:−0.58
BCL6
●
ARHGEF1
● ●
P−value:0.96; Pearson R:0.016
●
−0.5
●
●
−1.0
●
●
−1.5
0.5
● ●
−0.5 0.0
ARHGEF1
1.0
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
ARHGEF11
1.5
●
P−value:0.75; Pearson R:0.11
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
−1.0
● ●
−0.5
0.8 0.4
●
● ●
● ●
●
●
0.5 1.0 1.5 2.0 2.5 3.0
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.5
● ● ● ●
●
−1.0
● ●
−1.6
−1.2
−0.8
−0.4
0.4
●
0.0
●
● ●
●
● ●
●
−0.4
●
●
DLG1
0.5 0.0
●
●
●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
●
P−value:0.38; Pearson R:0.29
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
0.8
BCL6
P−value:0.022; Pearson R:0.68
BCL6
●
ARHGEF12
●
P−value:0.094; Pearson R:0.53
●
● ●
0.0
●
●
−0.4
0.0
●
−0.5
ARHGEF12
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
DLG1
0.5
●
P−value:0.66; Pearson R:0.15
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
−0.5
●
●
0.8 0.4
● ●
●
0.5 1.0 1.5 2.0 2.5 3.0
●
● ●
−0.5
●
0.5 1.0 1.5 2.0 2.5 3.0
● ● ●
●
●
● ●
−1.6
●
−1.2
−0.8
−0.4
0.4
●
●
0.0
●
● ●
●
●
●
−0.4
●
●
●
DLG3
●
●
−1.6
ZBTB7A
●
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.4; Pearson R:−0.28
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
0.8
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
P−value:0.63; Pearson R:−0.16
BCL6
0.0
BCL6
−0.8 −0.6 −0.4 −0.2
DLG2
●
P−value:0.37; Pearson R:0.3
● ●
●
0.0
●
●
●
−0.4
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
DLG3
●
P−value:0.4; Pearson R:−0.28
−0.8 −0.6 −0.4 −0.2
DLG2
0.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
−2.5
●
●
−0.5
1.5 1.0
●
● ●
●
●
● ● ●
0.5 1.0 1.5 2.0 2.5 3.0
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−2.0
●
●
● ●
−2.5
●
●
−1.6
−1.2
−0.8
−0.4
1.5 1.0
●
●
0.5
● ●
●
●
0.0
●
FYN
−1.0 −1.5
●
●
●●
● ● ●
●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.3; Pearson R:−0.34
BCL6
P−value:0.26; Pearson R:0.37
BCL6
●
DLG4
●
P−value:0.22; Pearson R:0.4
● ●
●
0.5
●
●
0.0
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
FYN
−1.5
●
−2.0
DLG4
−1.0
●
P−value:0.73; Pearson R:−0.12
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
−1.0 −2.0 −0.5
4
●
●
●
●
●
0.5 1.0 1.5 2.0 2.5 3.0
●
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
●
−2.0
−1.0
●
●
−1.6
−1.2
−0.8
−0.4
4
●
●
3
●
●
2
●
●
●
●
●
●
1
●
● ●
●
●
0
0.0
●
●
LLGL2
●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.53; Pearson R:−0.21
BCL6
0.5
BCL6
●
LLGL1
● ●
0
●
P−value:0.25; Pearson R:−0.38
LLGL1
● ●
●
P−value:0.27; Pearson R:−0.36
●
●
3
●
2
0.0
●
●
1
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
LLGL2
●
P−value:0.17; Pearson R:0.45
0.5
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
−0.5
0.0
●
● ● ●
●
0.5 1.0 1.5 2.0 2.5 3.0
●
●
−0.5
●
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−2 −3
●
●
−1.6
−1.2
−0.8
−0.4
−0.5
●
●
−1.0
●
−1
0
●
●
●
−1.5
●
●
●
● ●
●
−2.0
●
●
MAP2K7
1
● ●
●
−1.6
ZBTB7A
●
−1.2 ZBTB7A
Biology Open | Supplementary Material
●
−0.8
P−value:0.051; Pearson R:0.6
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
0.0
BCL6
P−value:0.87; Pearson R:−0.057
BCL6
●
MAP2K4
●
●
P−value:0.26; Pearson R:−0.37
0 −1 −2
●
−3
MAP2K4
●
−0.5
●
● ●
−1.0
●
●
−1.5
●
−2.0
1
● ●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
MAP2K7
●
P−value:0.27; Pearson R:0.37
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
1.5
● ●
●
●
●
●
● ●
●
●
● ● ●
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
●
●
●
●
−1.6
−1.2
−0.8
−0.4
1.0
●
●
●
0.5
●
●
●
●
0.0
● ●
MAPK8
●
●
●
● ● ●
● ●
●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.076; Pearson R:0.56
BCL6
P−value:0.63; Pearson R:−0.17
BCL6
1.5
0.5 1.0 1.5 2.0 2.5 3.0
●
−2.5 −2.0 −1.5 −1.0 −0.5
MAPK10
−0.5
1.0
●
●
0.5
●
●
0.0
●
MAPK8
● ●
P−value:0.59; Pearson R:0.18
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
P−value:0.74; Pearson R:0.11
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−2.5 −2.0 −1.5 −1.0 −0.5
MAPK10
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
0.5
●
●
−0.5
2 1 0
●
●
● ●
●
●
●
0.5 1.0 1.5 2.0 2.5 3.0
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
●
1.0
●
●
●
0.5
●
●
−1.6
−1.2
−0.8
−0.4
1 0
●
●
●
−1
●
−2
1.5
●
● ●
SCRIB
2.0
● ●
●
● ●
●
●
●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.99; Pearson R:−0.0039
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
2
BCL6
P−value:0.29; Pearson R:−0.35
BCL6
●
MAPK9
●
P−value:0.37; Pearson R:0.3
● ●
● ●
−1
1.5
●
●
1.0
MAPK9
●
●
−2
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
SCRIB
2.0
●
P−value:0.42; Pearson R:−0.27
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
−0.5
●
●
●
−0.5
3
●
●
0.5 1.0 1.5 2.0 2.5 3.0
●
−0.5
0.5 1.0 1.5 2.0 2.5 3.0
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
● ● ● ●
−0.5
●
●
−1.6
−1.2
−0.8
−0.4
3
●
2
● ●
●
●
●
1
● ●
●
●
0
●
●
●
YES1
0.5 0.0
●
●
−1.6
ZBTB7A
−1.2 ZBTB7A
Biology Open | Supplementary Material
−0.8
P−value:0.13; Pearson R:−0.48
BCL6
P−value:0.17; Pearson R:0.45
BCL6
●
SRC
●
P−value:0.47; Pearson R:−0.24
●
● ● ●
2
●
●
●
●
1
●
●
0
0.0
SRC
●
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
YES1
0.5
●
P−value:0.63; Pearson R:−0.17
Grutzmann Pancreas : pancreatic ductal adenocarcinoma
−0.4
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●●
●
●
●
0.5
●
● ● ●
●
●
●
●
● ● ●
● ● ●
●
● ● ●
●
●
● ● ●
●
0
1
2
●
●
●
● ● ●
●
●
● ●
●
●● ●
●
● ●
● ●
● ●
●
●
1
2
3
●
●
●● ●
●
●●
● ● ●
●
● ● ●
●
● ●
●
● ●
●
●
●
●
●
−1.0
−0.5
0.0
0.5
1.0
0.5 1.0 1.5 2.0 2.5
● ● ● ●
●
●
●
● ● ●
●
● ● ●
● ●
● ●
●
●
● ● ●
●
●
●
●
●
● ●
●
●
● ●
● ●
●
● ●
●
●
●
●
−0.5
1.5 1.0
● ●
●
DLG3
Ma Breast 2 : all breast carcinoma
P−value:0.032; Pearson R:0.34
Ma Breast 2 : all breast carcinoma
●
● ● ●
BCL6
●
●
● ●
●
BCL6
● ●
0.5
LLGL1
● ●
●
0
●
−1.5
●
●
3
●
●
● ●
●
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.2; Pearson R:−0.21
●
●
●
0.5
1.0
P−value:0.94; Pearson R:−0.012
●●
0.5 1.0 1.5 2.0 2.5
●
●
●
●
−0.5
●
1.0
LLGL1
1.5
●
DLG3
Ma Breast 2 : all breast carcinoma
P−value:0.74; Pearson R:−0.055
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ● ●
●
● ●
●● ●
●
●
●
●
●
●
●
−0.5
● ● ●
0
1
● ●
●
2
●
0.8 0.6
● ●
●
●
●
●
●
●
●
●
● ●
●
● ●
● ●
0
1
2
3
●
●
● ●
●
●
●
●
● ● ● ●
●
●
● ●
●
●
●
●
●
● ●
●
●
●
−1.0
●
−0.5
0.0
0.5
●
1.0
0.6
●
0.4
● ● ●
● ● ●
0.2
● ●●
●
●
●
●●●
●
●● ●
●
● ● ●
●
●
●
● ● ●
●
−0.2 0.0
●
ARHGEF12
●
0.8
Ma Breast 2 : all breast carcinoma
P−value:0.52; Pearson R:0.11
Ma Breast 2 : all breast carcinoma
0.5 1.0 1.5 2.0
BCL6
●
●
● ● ● ● ● ● ●● ●
●
●
● ●
● ●
●
3
●
−1.5
● ●
BCL6
●●
−0.5
●
● ●
● ●
●
● ●
● ●
●
●
●
● ●
●
●
●
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.73; Pearson R:0.056
● ● ●
●
0.5
1.0
P−value:0.68; Pearson R:0.066
● ●
●
●
0.4
●
●
0.2
●
●
●
−0.2 0.0
●
ARHGEF12
●
●
SCRIB
Ma Breast 2 : all breast carcinoma
P−value:0.12; Pearson R:−0.25
0.5 1.0 1.5 2.0
SCRIB
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●●
●
● ● ●
●
● ●
●
●
●
●
●
●
● ●
●
●
●
●
● ●
●
−0.5
●● ● ●
0
1
1.5
●
● ●
●
●
●
●
● ● ●
●
●● ●
●
● ●
●
●
● ●
● ●
● ●
3
0
1
2
3
Ma Breast 2 : all breast carcinoma
Ma Breast 2 : all breast carcinoma
1.5
BCL6
0.5
● ●
●
●
● ●
●
● ● ●
●
●
●
●
●
0.0
●
●
● ●
●
●
●●
●
● ● ●
● ● ●
● ●
−0.5
●
●
●
●
● ● ● ●
●
● ● ●
● ● ●
● ●
● ●
● ●
● ●
● ●
●
●
●
● ●● ●
● ●
●
●
●
−1.0
●
●
1.0
●
●
0.5
● ●
●
●
0.0
1.0
●
SRC
1.5
● ●● ● ●
● ●
●
−1.5
● ●
BCL6
−0.5
MAP2K7
2
●
●
0.0
0.5
1.0
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.79; Pearson R:−0.043
●
P−value:0.4; Pearson R:0.14
0.5
●
●
0.5
1.0
P−value:0.91; Pearson R:−0.018
●
● ●
1.0
●
●
0.5
●
●
0.0
1.0
●
●
SRC
1.5
● ●
0.0
MAP2K7
Ma Breast 2 : all breast carcinoma
P−value:0.065; Pearson R:−0.29
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
●
0
●
●
● ● ● ●●
●
0
1
●
● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●
2
3
●
2
● ●
●
●
●
● ●
● ● ● ● ● ● ● ●
●
●
1
2
3
Ma Breast 2 : all breast carcinoma
●
●
●
●
0
●● ●
●
● ● ●
●
●
●
−1.0
−0.5
● ● ● ● ●●● ● ●
0.0
● ●● ●
0.5
● ●
● ●
1.0
3
●
2
● ●
● ● ● ●●
●
● ●●
●
●● ● ●
●
1
●●
●
● ●
●
●
●
●
● ● ●
●
●
● ●
●
●
●
● ●
0
●
●
LLGL2
3 1
2
●
● ●
●
Ma Breast 2 : all breast carcinoma
●
−1
●
●
BCL6
●
DLG2
●●
BCL6
●
−1.5
●
●
0
●
●
● ● ●
● ●
●
3
P−value:0.21; Pearson R:−0.2
−1
● ●
● ● ●
●
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.42; Pearson R:−0.13
●
●
● ● ●
1
1
DLG2
2
● ●
0
3
● ●
●
LLGL2
●
P−value:0.085; Pearson R:−0.28
Ma Breast 2 : all breast carcinoma
P−value:0.83; Pearson R:0.036
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●●
0.4
● ● ●
●
●●
●
●
0.2
●
●
●
●
●
●
●
● ●
● ●
●
0.0
●
●
0
1
2
0 −1
●
●
● ●
1
2
3
● ●
●
●
● ●
●
● ●
●
●
●
●
●
●
● ● ●
● ● ●
● ●
●
● ●
●
●
●
−1.0
−0.5
0.0
0.5
1.0
0 −1
●
−2
● ●
●
●
● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
● ●
● ● ●
●
●
●
●
−3
●
●
●
●
−4
●
●
●
●●
−5
●
● ●
●
YES1
●
●
P−value:0.34; Pearson R:−0.16
Ma Breast 2 : all breast carcinoma
0.8
Ma Breast 2 : all breast carcinoma
●
0.6
●
●
0
●
0.4
●
●●●
BCL6
●
0.2
●
●
●
3
0.0
ARHGEF1
●
BCL6
●
−1.5
●
●
●
● ●
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.84; Pearson R:0.034
●
●
●
●
0.5
1.0
P−value:0.36; Pearson R:−0.15
● ●
●
●
−2
●
●
●● ● ● ● ● ● ●● ● ● ●● ● ● ● ●
−3
●
●
●
●
−4
0.6
●●
●
−5
●
YES1
● ● ●
ARHGEF1
Ma Breast 2 : all breast carcinoma
P−value:0.46; Pearson R:−0.12
0.8
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
●
● ●
●
3
● ●
●
●
●
●
2
● ● ●● ●
1
●
●
●
●
● ●
● ●
0
1
2
2.0 ●
●
●
●
● ●● ●
● ● ● ●
●
● ● ● ●
●
●
●
● ●
● ● ● ● ● ●
●
1
2
3
3
●
● ● ● ● ●
●
●● ●
● ● ● ●
2
● ●
●
1
● ●
● ● ●
●
● ●
● ●
−1.0
−0.5
0.0
0.5
1.0
●
1.5
● ●● ●
1.0
●
● ●
●
●
●
●
●
●
●
●
● ● ● ● ●● ●
●
0.5
●
● ●
●
● ●
●
●
●
●
●
●
● ●
● ●●
−0.5
●
MAPK9
●
●
5
●●
2.0
Ma Breast 2 : all breast carcinoma
6
Ma Breast 2 : all breast carcinoma
●
4
●
0
●
−1 0
●
BCL6
●
MAPK10
● ● ●
BCL6
●
−1.5
●
3
P−value:0.077; Pearson R:−0.28
−1 0
●
●
● ● ●
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.68; Pearson R:0.068
4
●
●
0.5
1.0
P−value:0.34; Pearson R:0.15
●
●
● ●
1.5
●
1.0
5
● ●
0.5
●
●
−0.5
● ●
MAPK9
● ●
MAPK10
Ma Breast 2 : all breast carcinoma
P−value:0.45; Pearson R:0.12
6
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ●
● ●●
●
●
●
●
●
●● ● ●
●
● ●
●
●
0
● ●
●
●
●
●
●
1
2
2 0
● ●
● ● ●
● ●
● ●
●
1
2
3
Ma Breast 2 : all breast carcinoma
● ● ●
● ●
−0.2
●
●
●
● ● ●
●●
●
● ● ● ● ● ● ● ●
●
−1.0
●
●
−0.5
●●
0.0
●
● ●●
0.5
●
●
1.0
●
●
2
● ●
0
●
●
●
● ● ●
●
●
●
● ● ● ●●● ● ● ● ● ● ●
●● ● ●
●● ●●
●
●
−2
●
● ●
●
−4
●
●
MAP2K4
●
● ●
●
Ma Breast 2 : all breast carcinoma
1.0 0.6
●● ●●
●
●● ●
BCL6
●
0.2
●
● ● ●
●
BCL6
●
DLG4
●
●
0
●
−1.5
●●
●
●
●
●
3
P−value:0.39; Pearson R:−0.14
−0.2
● ●
●
●● ●
●
−2
●
● ● ●
−4
0.6
●
● ●
0.2
DLG4
●
●
MAP2K4
●
P−value:0.1; Pearson R:0.26
1.0
●
●
−1.5
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
P−value:0.68; Pearson R:0.068
Ma Breast 2 : all breast carcinoma
0.5
1.0
P−value:0.96; Pearson R:−0.0088
Ma Breast 2 : all breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
●
●
● ●
● ●
● ●
●
●●
●
●
●
● ●
●
●
●
● ●●
●
−1.0
●
● ●●
● ●
● ●
●
0
1
2
0.8
1.0
Ma Breast 2 : all breast carcinoma
no data
● ● ● ● ●
● ●
● ● ●
●
●
● ●
● ●
● ● ● ● ● ● ●
● ●
●
● ●
−1.0
−0.5
0.0
0.5
1.0
1.2
1.4
0.5 0.0 −0.5
−0.5
●
●
●
● ●
1.4
−1.0
0.0
● ●
ARHGEF11
0.5
●
●
1.2
1.0
BCL6
P−value:0.21; Pearson R:−0.2
BCL6
−1.0
MAPK8
1.0 0.6
●
−1.5
0.5
3
●
●
0.0
0.0
●
● ●
−0.5
MAPK8
●
−0.5
●
●
−1.0
●
ARHGEF11
0.5
●
P−value:0.49; Pearson R:0.11
Ma Breast 2 : all breast carcinoma
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.5 −0.5 −1.0 1.0
1.2
1.4
0.6
0.8
1.0
BCL6
BCL6
no data
no data
1.2
1.4
1.2
1.4
0.5 0.0 −0.5 −1.0
−1.0
−0.5
0.0
FYN
0.5
1.0
0.8
1.0
0.6
DLG1
0.0
FYN
0.0 −1.0
−0.5
DLG1
0.5
1.0
no data
1.0
no data
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ●
●
●
●
●
●
●
●● ●● ● ●
● ●
●
●
●
● ● ●
●●
● ●
●
●
●
0.6
0.8
1.0
1.2
●● ● ● ● ● ●
●
● ●
● ●
● ● ● ●● ● ● ●● ● ● ●●
●
● ● ●
●
● ●
0.4
●
●● ● ●
0.6
0.8
● ●
●
2.5
0.6
0.8
1.0
1.2
1.4
2.5
●
●
●
●
● ●
●
● ● ●
●
●
●
●
●
2.0
●
● ● ● ●
●
● ● ● ●
●
0.4
1.5
1.5 1.0
● ●
0.5
ARHGEF1
● ●●
● ● ● ●
●
●
●
● ●
●
●
●
●
●
Ma Breast 4 : all
●
●
●
●
●
●
● ●
Ma Breast 4 : all
●
● ●
●
●
●
●
●
● ●
BCL6
●
●
●
●
BCL6
●
● ●
2.0
1.4
●
●
●
● ●● ●● ● ● ● ●●
● ● ● ● ●●
●
1.0
0.4
● ●●
●
●
●
●
●
0.5
●
●● ●● ●
ARHGEF11
●
●
● ● ●
●
● ●
● ●
●●
●
● ● ●
●
●
●
●●
● ● ●● ● ● ●
● ●
●
●
● ● ●
●
1.0
ZBTB7A
●
● ●
● ● ●
● ● ●
●
●
● ● ●● ●
●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
●
●
●
1.0
P−value:0.72; Pearson R:−0.045
●
● ●
●
●
1.5
● ● ●
●
● ●
● ● ●●● ● ●
1.0
● ●
P−value:0.47; Pearson R:0.091
1.0
● ● ●
0.5
ARHGEF1
●
●
●
●
0.5
●
●
●
ARHGEF11
1.5
●
P−value:0.92; Pearson R:−0.012
Ma Breast 4 : all
P−value:0.12; Pearson R:−0.19
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
● ● ● ● ●
●
● ●
●
●
●
● ●
●● ●
●
●●
● ●
●● ●
●
● ●
●
●
●
●
0.6
0.8
1.2
●
●
● ●
●
−0.9
● ● ● ● ●
●
● ●
●
●
● ● ●
● ●● ●
● ●
●
●
●
●
●
●
● ● ● ● ● ● ●
●
●
●
●
● ●
●
● ●
−1.1
ARHGEF12
●
●
●
0.4
0.2
●
●
●
● ●
0.6
● ● ●
● ● ● ● ● ●
●
0.6
0.8
● ●
● ● ●
●
●
●●
●
0.8
1.0
1.2
1.4
●
●
0.2
●
●●
●
0.4
●
● ● ●● ●
●
0.0
● ●
●
● ●
●
● ●
●
Ma Breast 4 : all
●
●
●
● ●
Ma Breast 4 : all
●
●
●
●
● ●
BCL6
●
●
1.4
●
● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ●
BCL6
● ●
−0.7
1.0
● ●
● ● ● ●
●
●
−0.2
0.4
●
● ●
●
●
●
● ●
● ●
●
●● ●
● ●
1.0
ZBTB7A
●
0.4
0.6
●
●
● ● ● ● ●
●
●
● ● ● ● ● ● ● ● ● ● ●
0.8
ZBTB7A
Biology Open | Supplementary Material
● ●
●
● ●● ● ● ● ● ● ●
●
● ●
−0.4
−1.1
●
●
P−value:0.72; Pearson R:0.044
●
●
DLG1
−0.9
● ●●●
● ●
●
P−value:0.56; Pearson R:−0.074
●
●
●
●
●
●
●
1.0
P−value:0.18; Pearson R:−0.17
●
0.0
● ●
●
●
●
●
●
−0.2
● ● ●
●
−0.4
●
● ● ●
ARHGEF12
●
●
DLG1
−0.7
●
Ma Breast 4 : all
P−value:0.024; Pearson R:0.28
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ●● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ●
● ●
●
●
●
●
●
0.6
0.8
1.0
1.2
1.4
−0.8
● ●
●
● ● ●
● ● ●
● ● ● ●
0.4
● ●
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●
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●
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●
● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ●● ●● ●
● ●
● ●
●
● ●
● ● ● ●
0.6
●
0.8
●
● ● ● ● ●
●
● ●
●
0.4
0.6
0.8
1.0
●
●
1.2
Ma Breast 4 : all
●
● ●
●
●●
●
●
●
● ●
Ma Breast 4 : all
● ●
●
BCL6
● ●
●
●
BCL6
●
●
−1.2
DLG2
−0.4
0.4
●
●
●
●
0.5 1.0 1.5 2.0 2.5 3.0
−1.2
● ●●
● ●
DLG3
● ●
●
1.4
● ●
●
●
● ●
●
●
● ●
●
●
●
●
●
● ●
● ●
● ●
● ● ●
●
● ● ● ●
● ●
● ●
● ●
1.0
ZBTB7A
●
●
● ●
● ●
● ●
● ● ●● ● ●
● ●
●● ●
● ●●
●
●
●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
●
●● ● ●●
P−value:0.56; Pearson R:−0.074
●
P−value:0.21; Pearson R:−0.16
●
●
●
● ●
● ●
●
1.0
P−value:0.83; Pearson R:−0.027
●● ●
●
0.5 1.0 1.5 2.0 2.5 3.0
● ●
DLG3
●
P−value:0.82; Pearson R:−0.028
Ma Breast 4 : all
●
−0.8
DLG2
−0.4
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
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●
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●
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●
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0.6
0.8
1.0
1.2
●
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● ● ●
● ●
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● ● ● ●● ● ● ● ● ● ● ●
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●
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●
●
● ●
●
●
● ●
0.4
1.0
0.6
0.8
1.0
0.6
0.8
● ● ● ●●
●●
●
1.2
1.4
●
1.0
−0.8 −0.6 −0.4 −0.2
DLG4
●
●
●
●
● ● ● ●
●
●
●
Ma Breast 4 : all
●
● ●
●
● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ●● ● ● ● ●
0.4
●
Ma Breast 4 : all
●
●
●● ● ● ●● ●● ●
● ●
BCL6
●
● ●
●
BCL6
●
● ●
0.5
1.4
●
● ●
● ●
●
0.5
0.4
●
●
0.0
●
●
●
● ●
● ●
●
●
● ●
●●
1.0
ZBTB7A
●●
● ● ●
●
●
● ●
●●
● ●● ● ●● ●● ● ●
● ● ● ● ● ● ●
●
●
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
●
● ● ● ● ●● ● ●● ●● ● ● ●●
●
0.4
●
●
●
−1.0 −0.5
●
●
●
●
●
●
1.0
P−value:0.29; Pearson R:−0.13
●
FYN
●
●
0.0
●
●● ● ● ● ● ● ● ●
−1.0 −0.5
●
●●
●
FYN
●
●
P−value:0.44; Pearson R:0.096
−0.8 −0.6 −0.4 −0.2
DLG4
●
P−value:0.25; Pearson R:−0.14
Ma Breast 4 : all
P−value:0.85; Pearson R:−0.023
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ●● ●
●●
●
●
0.6
0.8
1.0
1.2
1.4
●
2.0
●
● ● ●● ●● ●
1.8
● ●
1.6
● ● ● ● ●
● ● ●
●
● ●
● ●
● ● ● ●
●
1.2
●●
● ●
●
●
●
● ● ●
● ●●
● ●
●
●
●
●
●
●
●
● ● ● ● ●
●
●
0.4
●
●
●
● ● ●
● ●
●
●
● ● ●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ●
●
0.6
0.8
●
● ● ● ● ● ● ●
●
● ● ●
●
0.4
0.6
0.8
1.0
1.2
Ma Breast 4 : all
●
●
● ●
Ma Breast 4 : all
●
●
●
BCL6
●
●● ●
●
●
●
●
BCL6
2.2
0.4
●
● ● ●●
●
1.4 1.6 1.8 2.0 2.2 2.4
1.4
●
● ●
●● ● ● ● ● ●●
1.2
●
●
●● ● ● ● ● ●
● ●
●●
●
● ●
●
LLGL2
●
●
● ●● ●●
●
●
●
●
●
●
● ●
●
● ● ●
●
●
● ● ● ●
●
● ●
● ●
ZBTB7A
●
● ● ●
● ●● ●● ● ●● ●
●● ●
●
●
●
● ●
●
● ●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
● ●
● ●
● ●
● ● ● ●
●
● ●
● ● ●
●
●
●
●
●
1.0
1.4
●
●
P−value:1; Pearson R:7e−04
● ●
●
1.0
P−value:0.85; Pearson R:0.023
●
P−value:0.15; Pearson R:0.18
1.8
●
1.4 1.6 1.8 2.0 2.2 2.4
2.0
●
●● ●
●
●
●
1.4
●
●
●
1.6
LLGL1
●
LLGL2
● ●
●
LLGL1
Ma Breast 4 : all
P−value:0.0013; Pearson R:0.39
2.2
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
2
●
●
●
●
● ● ●
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●
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1
●
●
0.6
0.8
● ●
●
● ● ●
● ● ●
● ● ● ● ● ● ● ● ● ● ●● ●● ●
●
●
●● ● ●
●
● ● ●●
●
● ● ● ● ●
● ●
● ●
●
1
●
●
0.4
●
● ● ● ●● ● ●
−0.2
●
●●
●
●
● ●●
●
● ●
0.6
0.8
●
●
●
●
●
●
●●
● ●
●
●●
●
0.6
0.8
1.0
1.2
1.4
−0.2
● ●
●
−0.4
●
● ●
●
●
● ● ●● ●
●
●● ●
●
● ●
●
● ● ●
● ● ●
−0.6
●
●
0.4
●
●
● ●
●
●
●
● ● ●
● ●
● ●
●
●
● ●● ●
● ● ●
●
●
● ●●
● ● ● ●
●
●
● ●● ● ●● ● ●
●
●
−0.8
5 4 3
● ●
●
Ma Breast 4 : all
●
●
● ●
Ma Breast 4 : all
● ●
●
BCL6
●
●
●
●
1.4
●
●
● ●
●
BCL6
●
● ●
2
1.2
●
●
MAP2K4
1.0
● ●
●
●
●
●
● ●
−1.0
0.4
●
●
1.0
ZBTB7A
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.23; Pearson R:0.15
●
●● ●● ●● ● ● ● ● ● ● ● ●● ●
●
●
●
1.0
P−value:0.21; Pearson R:0.16
●
●● ● ● ●
●
●
−0.4
●
−0.6
●
●
●● ●
●
●
● ●
−0.8
● ●
● ●
●
−1.0
●
●
●
MAP2K7
●
●
P−value:0.037; Pearson R:−0.26
4
●
●
3
●
●
MAP2K7
5
●
●
MAP2K4
Ma Breast 4 : all
P−value:0.0034; Pearson R:−0.36
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ● ● ● ● ● ● ●● ● ●
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0.6
● ● ●
0.8
●
●● ● ●
●
●
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●
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●
1.0
1.2
● ● ● ●
●
●● ● ●●
●
●
●
●
●
● ●
●
● ● ● ●● ● ● ● ● ● ● ● ● ● ●
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0.4
●
0.6
●
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0.8
●
●
●
●
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●
●
●
● ●●● ●
●
●
● ● ●●
●
0.6
● ●
● ● ● ●
● ●●
●
0.8
1.0
1.2
1.4
0.6
● ●
●
● ●
● ●
0.2
● ●
●● ●●
●
0.4
●●
●●● ●
● ●
●
●
−0.2
● ●
●
●● ● ● ● ● ●
●
● ●
●
●
●
●
● ●
1.0
ZBTB7A
●
●● ● ●
● ● ●
●
● ● ● ● ●● ● ●
● ●●
●
0.4
0.6
●
● ●
● ●
●
●
● ● ●
●
●
0.8
ZBTB7A
Biology Open | Supplementary Material
●
● ●
●
●
● ●
●
−0.6
0.5
●
−0.5
MAPK10
1.5
●
● ●
●● ●●
●
● ● ●
Ma Breast 4 : all
●
●
●
●
●
Ma Breast 4 : all
●
● ● ●
0.6
1.4
●
●
● ●
●
BCL6
●
●
●
BCL6
2.5
0.4
● ● ● ●● ●● ● ●●
●
● ● ●
●
●
●
P−value:0.14; Pearson R:−0.18
●
MAPK8
−0.5
●
●●
●
●● ●● ●
P−value:0.25; Pearson R:−0.14
●
●
●
1.0
P−value:0.44; Pearson R:0.098
●
●
0.2
● ●
●
●
−0.2
●
●
−0.6
●
0.5
MAPK10
1.5
●
●●
MAPK8
● ●
P−value:0.92; Pearson R:−0.012
Ma Breast 4 : all
2.5
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●● ● ●●
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●
●●
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●
●
●
●
−0.4
● ●
●
0.6
0.8
1.0
1.2
●
● ● ● ●● ●● ● ● ● ● ● ● ●
● ●
●
●
●
●
●
●
●
● ● ●
● ●
●
●
●
● ● ●
● ●
0.6
0.8
● ●
●
●
0.4
0.6
0.8
1.0
1.2
5.5
1.4
● ●
● ●
● ●●
●
4.5
●
●● ●
● ●
● ●
● ●
● ●
● ●
●
●
●
●
●
● ●
● ●
● ● ●
●● ● ● ● ●
●
● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
● ● ● ●
●
ZBTB7A
●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
● ●
●
●
1.0
● ●●
●
●
3.5
−0.2
●
●
2.5
0.2 0.0
●
●
0.4
●
●
● ●
SCRIB
● ● ●● ● ●● ●
●
● ●
●
●
Ma Breast 4 : all
●
●
●
● ● ● ● ● ● ● ●● ● ●
●
●
●
●
●
Ma Breast 4 : all
●
●
●● ●●
●
●
BCL6
●
● ●
●
1.4
●
●
●
●
●
●
BCL6
●
−0.4
●
● ●
0.4
MAPK9
●
● ●
● ●
P−value:0.23; Pearson R:−0.15
● ●
● ● ●
●
●
●
●● ● ●
1.0
●
P−value:0.011; Pearson R:0.31
● ●● ● ●
● ● ●
4.5
●
P−value:0.89; Pearson R:−0.018
0.0
● ●
●
●● ●● ● ● ● ●
●
●
−0.2
MAPK9
● ● ● ●●
● ● ●
3.5
● ●
●
● ●
2.5
●
SCRIB
0.2
●
5.5
Ma Breast 4 : all
P−value:0.26; Pearson R:−0.14
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
● ● ● ● ● ● ● ● ● ● ● ● ●
● ● ●
● ● ●
●●
●
● ● ● ● ●●
● ●
●
●
●
−0.5
● ● ●
0.6
0.8
1.2
● ● ● ● ● ● ●
●
●
● ●● ●
●
● ●● ●
●
●
●
●
● ●
●
● ● ● ●
●
● ● ●● ●
●
●●
● ●
−0.3
3.5
0.8
1.0
●
● ●
●
● ●
●
0.6
0.8
1.2
●
●
3.5
1.4
●
●
● ● ●
3.0
−0.1
●
−0.5
SRC
● ●● ●● ●
●
0.4
0.6
● ●
● ● ●
●
●
●
●
●
● ●
●
● ●● ●● ● ● ● ● ●
● ● ● ● ● ● ● ●● ● ●● ● ●
●
2.5
●
●
0.4
● ●
● ●●● ● ●
●
●
●
●
● ●
● ●
●
2.0
● ●
●
●
Ma Breast 4 : all
●
●
●
●
Ma Breast 4 : all
●
●
●
1.4
●
●
●
BCL6
●
● ●
● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
BCL6
●
0.1
1.0
●
●
YES1
0.4
● ●
● ● ● ● ●
1.0
ZBTB7A
●
● ●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
1.0
P−value:0.54; Pearson R:−0.078
●
●
● ●
●
●● ● ● ● ●● ●● ●
3.0
● ●
●
2.5
●
● ●
●
● ●
●
●
P−value:0.25; Pearson R:0.14
−0.1
● ● ●
−0.3
SRC
●
●
● ●
2.0
0.1
● ●
● ● ●
YES1
●
●
P−value:0.49; Pearson R:−0.086
Ma Breast 4 : all
P−value:0.47; Pearson R:0.091
Ma Breast 4 : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●●
● ● ●
●
●
●
● ●
●
●
●
●
0.6
0.8
1.0
1.2
1.4
●
●
● ●
● ●
●
● ● ●
● ●
●
● ●
1.4
●
0.4
0.6
0.8
1.0
1.2
BCL6
BCL6
Ma Breast 4 : normal
Ma Breast 4 : normal
●
● ● ● ●
● ●
●
●
●● ● ●
●
●
●
●
●
●
●
● ●
●
●
●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
1.4
● ● ●
●
● ● ● ● ●
● ●
1.0
●
●
● ●
● ●
0.6
●
1.4
● ●
●
● ● ● ●
● ● ●
●
0.2
●
●
P−value:0.46; Pearson R:−0.14
●
●
●
●● ● ●
P−value:0.096; Pearson R:0.32
●
●
1.0
●
● ●
●
0.6
●
●
● ●
0.2
● ●
●
●
ARHGEF11
0.2 0.4 0.6 0.8 1.0 1.2 1.4
● ●
●
ARHGEF11
●
P−value:0.17; Pearson R:−0.27
●
0.4
ARHGEF1
Ma Breast 4 : normal
P−value:0.35; Pearson R:0.18
0.2 0.4 0.6 0.8 1.0 1.2 1.4
ARHGEF1
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
● ●
● ●
● ●
●
●
● ● ●●
●
●
0.6
0.8
1.0
1.2
0.1
● ●
● ● ●
●
0.6
0.8
1.0
1.2
BCL6
Ma Breast 4 : normal
Ma Breast 4 : normal
●
● ●
●
●
●
●
● ●
●
● ●
● ● ●
●
●
● ●● ●
●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
0.1
●
●
−0.1
●
●
●
●
● ● ●
● ●
●
−0.3
●
1.4
●
●
●
●
●
● ●● ●
●
●
●
−0.5
● ●
●
●
BCL6
●
●
● ●
● ●
0.4
●
●
●
DLG1
−1.1 −1.0 −0.9 −0.8 −0.7
● ● ●●
1.4
●
ARHGEF12
● ●
● ●
●
●
●
0.4
−0.1
●
●
−0.3
●
●
●
−0.5
●
DLG1
●
●
P−value:0.1; Pearson R:0.31
● ●
P−value:0.17; Pearson R:−0.27
−1.1 −1.0 −0.9 −0.8 −0.7
ARHGEF12
●
●
●
● ●
●
P−value:0.32; Pearson R:−0.19
Ma Breast 4 : normal
P−value:0.93; Pearson R:0.018
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ●
●
●
●
● ●
●
●
●
●
●
−1.3
● ●
0.6
0.8
1.0
1.2
● ●
●
● ●
●
● ●
● ●
●
0.4
0.6
0.8
1.0
1.2
Ma Breast 4 : normal
●
●
●
●
● ● ●
●
−1.1
● ●
● ●
●
●
●
●
●
● ● ●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
●
1.5
● ●
● ●
● ●
● ●
●
● ● ●
1.0
●
1.4
●
● ●
●
●
● ● ●
●
● ●
0.5
●
●
● ●
●●
DLG3
●
2.0
Ma Breast 4 : normal
P−value:0.88; Pearson R:−0.031
−0.9
●
BCL6
●
−1.3
●
●● ●
●
1.4
●
DLG2
● ●
BCL6
−0.7
0.4
●
●
●
P−value:0.4; Pearson R:−0.16
●●
●
●
P−value:0.00051; Pearson R:0.61
●
●
●
●
●
1.5
● ●
●
●
●
1.0
●
●
0.5
●●
−1.1
DLG2
−0.9
●
DLG3
●
2.0
Ma Breast 4 : normal
P−value:0.64; Pearson R:−0.093
−0.7
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
●
●
●
● ●
●
●
●
●
−0.8
● ● ● ●
0.6
●
0.8
1.0
1.2
●
●
−0.2
●
● ●
● ●
●
● ●
0.4
0.6
0.8
1.0
1.2
Ma Breast 4 : normal
● ● ●
●
●
●
● ●
●
● ● ●
●
−0.8
● ● ● ●
●
●
●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
●
−0.2
● ● ●
−0.6
●
●
● ● ●
● ●
● ●
●
●
● ● ●
−1.0
−0.4
● ●
1.4
●
FYN
●
●
●
●
●●
●
Ma Breast 4 : normal
●
−0.6
● ●
BCL6
●
DLG4
●
BCL6
●
●
●
●
●
1.4
P−value:0.53; Pearson R:0.12
0.4
●
● ●●
● ●
● ●
● ●
● ●
● ●
P−value:0.64; Pearson R:−0.093
●
−0.6
DLG4
●
●
−0.6
● ● ●
●
−1.0
−0.4
●
●
FYN
●
●
P−value:0.16; Pearson R:−0.28
Ma Breast 4 : normal
P−value:0.47; Pearson R:−0.14
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●●
●
●
●
●
●
●
● ● ● ●
1.4
● ●● ●
1.2
●●
●
0.6
0.8
1.0
1.2
2.2 2.0
●
●
●
●
● ●
●
0.4
0.6
0.8
1.0
1.2
●
● ●
● ●
●
● ● ● ●
●
●
●
●
●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
2.2 2.0
● ● ● ●
1.8
● ●●
●
●
● ●
●
● ● ●
● ● ● ●
1.6
●
1.4
● ●
● ● ●
1.4
1.8
●
●
●
●
●●
LLGL2
2.0
●
P−value:0.39; Pearson R:0.17
●
1.6
●
Ma Breast 4 : normal
●
1.4
●
●
1.4
●
1.2
●
●
Ma Breast 4 : normal
●
LLGL1
● ●
BCL6
●
●
● ● ●
BCL6
2.2
0.4
●
● ● ●
● ●
● ●
●
●
P−value:0.019; Pearson R:0.44
● ●●
● ● ●
1.8
●
1.8 1.6
LLGL1
●
●
1.6
2.0
●
1.4
●
LLGL2
● ●
P−value:0.79; Pearson R:0.053
Ma Breast 4 : normal
P−value:0.018; Pearson R:0.44
2.2
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
●
●
2.0
● ●
●
●
● ●
●
1.0
●
●
0.6
0.8
1.0
1.2
●
● ● ●
●
●
●
●
●
●
● ● ● ●
●● ●
1.4
●
0.4
0.6
0.8
1.0
1.2
Ma Breast 4 : normal
●
●
●
2.5
● ●
● ● ● ●
2.0
● ●
●
●
● ●
● ●
●
1.0
●
●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
● ● ●
−0.4
●
●
●
●
●
● ●
−0.6
●
1.4
●
● ● ● ● ● ●
−0.8
●
●● ●
● ● ●
●
●
●
● ●
−1.0
3.0
●
MAP2K7
● ●
−0.2
Ma Breast 4 : normal
●
1.5
●
● ●
BCL6
●
MAP2K4
● ●
BCL6
3.5
0.4
●
●
P−value:0.54; Pearson R:0.12
●
●
P−value:0.16; Pearson R:0.27
2.5
●
●
●
1.5
MAP2K4
●
● ●
−0.4
●
−0.6
●
−0.8
●
●
−1.0
●
P−value:0.38; Pearson R:−0.17
3.0
●
MAP2K7
●
● ●
−0.2
Ma Breast 4 : normal
P−value:0.0012; Pearson R:−0.58
3.5
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●●
●
●
●
● ●
●
● ● ●
−0.5
● ● ● ●
0.6
0.8
1.0
1.2
● ●
0.2
● ● ●
●
●
● ●
0.4
0.6
0.8
1.0
1.2
●
● ●
● ●
● ●●
●
● ● ●
●
−0.5
●
● ● ●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
0.4 0.2
●
●●
●● ●
0.0
● ●
1.4
●
● ●
●
●
●
●
●
● ● ●
● ●
● ●
●
−0.4
●
MAPK8
● ●
●
●
●
Ma Breast 4 : normal
●
0.5
●
Ma Breast 4 : normal
●
0.0
● ●
●
BCL6
●
MAPK10
●
●
BCL6
●
●
●
●
●
1.4
P−value:0.085; Pearson R:−0.33
0.4
● ● ●
● ● ●
● ●
P−value:0.39; Pearson R:−0.17
●
●
●
●
●
P−value:0.85; Pearson R:0.038
● ●
0.0
●●
● ●
−0.4
●
MAPK8
● ● ●
0.0
MAPK10
0.5
●
0.4
Ma Breast 4 : normal
P−value:0.91; Pearson R:0.024
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ● ●
● ●
● ● ● ●
● ●
●
●
●
●
● ●
−0.4
● ● ●
0.6
0.8
1.0
1.2
1.4
●
●● ●
● ●
●
● ● ●
●
● ●
●
0.6
0.8
1.0
1.2
● ● ● ●
●
● ●
●
● ●
●
● ●
●
●
● ● ● ● ●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
1.4
●
2.5 3.0 3.5 4.0 4.5 5.0
●● ●
●
● ●
0.4
SCRIB
0.2 0.0
●
●
−0.2
● ●
●
Ma Breast 4 : normal
●
●
● ●
Ma Breast 4 : normal
●
−0.4
● ●
BCL6
●
MAPK9
●
BCL6
P−value:0.68; Pearson R:−0.082
0.4
●
●
●
●
●
● ● ● ● ●
●
●
●
●
● ●
●
● ● ●
● ● ●
●
● ● ●
●
P−value:0.02; Pearson R:0.44
●
●●
●
2.5 3.0 3.5 4.0 4.5 5.0
0.0
●
−0.2
MAPK9
●
●
SCRIB
0.2
●
P−value:0.31; Pearson R:−0.2
Ma Breast 4 : normal
P−value:0.0063; Pearson R:−0.5
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ● ● ●
●
●
●
● ●
●
−0.4
●
●
●
0.6
0.8
1.0
1.2
3.2
0.6
0.8
1.0
1.2
Ma Breast 4 : normal
●
● ● ●
● ●
● ● ● ● ● ●
●
●
●
●
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
●
3.2
● ● ● ●
●
●●
● ● ●
● ●
●
● ●
●
●
●
2.8
0.0
● ●● ●
1.4
●● ●
●
●
● ● ●
2.4
●
2.0
●
●
−0.2
0.4
Ma Breast 4 : normal
●
−0.4
●
BCL6
●
●
●
●
● ●
1.4
●
SRC
● ● ● ●●
●
BCL6
●
●
●
● ●
●
YES1
0.4
●
●
●
P−value:0.058; Pearson R:−0.36
●
● ● ● ●● ●
2.8
●
● ● ●
2.4
●
P−value:0.44; Pearson R:0.15
0.0
● ● ●
−0.2
SRC
●
●
2.0
●
● ●
YES1
●
●
P−value:0.3; Pearson R:−0.2
Ma Breast 4 : normal
P−value:0.9; Pearson R:0.024
Ma Breast 4 : normal
0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
●
●
●
●
●
●
● ● ● ●
● ●
● ●
●
●
0.6
0.8
1.0
1.2
2.5 2.0
●
●
●
●
●● ● ●
●
●
●
●
●
●
●
●
●
● ● ●
●
● ●
0.6
0.8
1.0
1.2
1.4
BCL6
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
●
● ●
●
● ●
●
● ●
●
0.5
●
●
●
● ●●
● ● ●
●
● ● ●
● ●
0.4
0.6
0.8
2.5 2.0
●
●
●
●
1.5
● ●
●
●●
●
●
●
●
●
●
●
●
●
●
●
●
● ●●
●
1.0
●
●
●
●
●
●
● ●
● ●
●
●
●
●
●
0.5
● ●
●
ARHGEF11
1.5
●
P−value:0.63; Pearson R:0.081
BCL6
●
1.0
●
●
●
●
●●
1.4
●
ARHGEF1
●
● ●
●
●
1.0
ZBTB7A
●
● ●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.82; Pearson R:0.039
●
1.0
P−value:0.96; Pearson R:−0.0081
● ●
●●
● ● ●● ● ●
●
●
1.5
●
●
●
●
1.0
● ●
●
0.5
1.0
●
0.5
ARHGEF1
●
●
ARHGEF11
1.5
●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.34; Pearson R:−0.16
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ● ●
●●
● ●
● ●
−1.0
●
●
● ●
●
●
● ●
●
●
●
● ●
0.6
0.8
1.0
1.2
●
● ● ●
● ●
● ●
●
● ●
●
● ● ● ● ●
●
●
●
1.4
●
●
●
●
● ●
●
●
0.6
●
0.8
1.0
1.2
1.4
BCL6
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
●
−0.8
● ● ● ●
● ●
−0.9
●
●
●
● ●
●
●
● ●
● ●
●
●
●
●
●
●
● ●
● ●
●
● ●
0.4
0.6
0.8
0.2
●
0.0
●
●
● ● ●
●
●
−0.2
−0.7
●
●
●
●
●
●
●
● ●
● ●
1.0
ZBTB7A
●
● ● ● ●
●● ● ● ● ● ●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
●
●
●
●
●
−0.4
●
DLG1
● ●
●
−1.0
●
●
BCL6
●
ARHGEF12
● ● ● ●
P−value:0.21; Pearson R:0.21
●
●
● ●
●
1.0
P−value:0.2; Pearson R:−0.21
●
P−value:0.9; Pearson R:0.021
−0.8
● ●
−0.9
ARHGEF12
●
●
0.2
● ● ●
●
●
0.0
●
−0.2
−0.7
●
−0.4
●
DLG1
●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.12; Pearson R:0.26
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
● ● ●●
●
●
●
● ●
●
●
●
●
● ● ●
●
0.8
1.0
1.2
3.0 2.5 2.0
● ● ●
●
●
●
●
●
●
●
● ● ●
●
●
● ● ● ● ●
●
●
●
●
1.4
0.6
0.8
1.0
1.2
1.4
BCL6
BCL6
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
●
● ● ●
● ● ● ●
● ● ●
● ●● ●●
●
● ●
●
●
● ●● ● ●●
●
● ●
● ● ●
●
0.4
● ●
0.6
0.8
3.0
●
●
●
● ●
2.5
●
●
● ●
2.0
●
●
●
●
●
● ●
1.5
●
●
● ●
●
● ●
● ●
●●
●
1.0
●
●
● ●
●
●
● ●
●
●
●
●
1.0
ZBTB7A
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.78; Pearson R:−0.046
●
●
1.0
P−value:0.36; Pearson R:−0.15
● ● ●
●
●
●
●
●
●
●
1.5
●
●
● ●
1.0
●
●
●
●
●
DLG3
−1.2 −1.0 −0.8 −0.6 −0.4
●
● ●
●
0.6
DLG2
●
● ●
● ●
DLG3
●
P−value:0.93; Pearson R:0.015
●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.15; Pearson R:−0.24
−1.2 −1.0 −0.8 −0.6 −0.4
DLG2
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
●
●
● ●
● ● ● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
0.6
0.8
1.0
1.2
1.0 0.5
● ● ●
● ● ● ●
●
●
●
● ● ●
● ●
●
●● ●
●
●
●
●
●
●
● ●
●
● ●
● ●
0.6
0.8
1.0
1.2
1.4
BCL6
BCL6
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
● ●
●
● ●
● ●
● ●● ●
●
●
●
●●
●
●
● ● ●
●
● ●
● ●
●
●● ● ●
●
●
0.4
0.6
0.8
1.0 0.5
●
●
●
0.0
●
● ● ●
−1.0 −0.5
●
●
FYN
−0.8 −0.6 −0.4 −0.2
● ● ●
1.4
●
DLG4
●
●
●
● ●
●
●
● ● ●
1.0
ZBTB7A
●●
●
● ● ●
●
● ●
●
● ●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
●
● ● ●●
●● ●● ●●
P−value:0.52; Pearson R:−0.11
●
1.0
P−value:0.56; Pearson R:−0.098
●
●
●
0.0
●
● ●
−1.0 −0.5
●
●
FYN
●
●
P−value:0.35; Pearson R:0.16
−0.8 −0.6 −0.4 −0.2
DLG4
●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.78; Pearson R:0.047
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●
●
● ●
●
●
● ● ●
●
● ●
●
●
1.4
● ●
●
●
●
● ●
● ●
0.6
0.8
1.0
1.2
2.4
●
●
2.2
● ●
● ●
●
● ●
●
●
●
● ●
●
●
●
●
●
●
●●
●●
●
● ● ●
1.4
0.6
0.8
1.0
1.2
1.4
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
●
●●
●
●
1.6
● ●
●
● ● ●
●
● ●
●
● ●
●
●
● ●
● ●
● ●
●
●●
2.4
●
●
2.2
● ● ●
● ● ●
0.6
●
● ●
●
● ● ●
●
● ● ●
● ●
● ●
●
●
●●
●
●
● ●
●
0.4
●
● ● ● ●
2.0
● ● ●
●
●
1.8
1.8
● ●
LLGL2
●
P−value:0.3; Pearson R:0.17
●
1.6
2.0
BCL6
●
1.4
●
●
BCL6
●
LLGL1
●
0.8
1.0
ZBTB7A
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.78; Pearson R:−0.047
● ● ●
● ● ●
1.0
P−value:0.44; Pearson R:−0.13
●
●
●
●
2.0
1.8
●
1.6
LLGL1
●
●
1.8
●
●
1.6
●
LLGL2
● ●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.039; Pearson R:0.34
2.0
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●
●
●
●
●●
● ● ●
●
●
●
● ●
●
●
●
2
● ●
●
● ●
● ●
●
0.6
0.8
1.0
1.2
−0.2
●
●
● ●
●
●
●
● ●●
●
●
●
● ●●
●
● ● ●
●
●
●
●
●
●
●
●● ●
0.6
0.8
1.0
1.2
1.4
BCL6
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
3
● ●
● ●
●
● ●
● ●
●
●
● ●
●
●
●
● ●
●
●
●
●
●
●
● ● ●
0.4
0.6
●
0.8
−0.2 −0.4
●
● ● ●
● ● ●
−0.6
●
●
●●
●
●
● ●● ● ●
●
●
●
−0.8
4
●
●
●
MAP2K7
5
● ●
P−value:0.19; Pearson R:−0.22
BCL6
●
2
● ●
1.4
●
MAP2K4
● ●
●
●
●
● ●
●
● ●
●
● ●
●
●
● ●
● ● ●
1.0
ZBTB7A
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.26; Pearson R:0.19
●
1.0
P−value:0.58; Pearson R:0.093
●
●
●
● ●
−0.4
●
−0.6
4
●
3
MAP2K4
●
−0.8
●
●
●
MAP2K7
5
●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.1; Pearson R:−0.27
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ●
●
●
●●
● ●
●
−0.5
●
●
● ●
0.6
● ●
●● ●
●●
●
●
●
●
●
0.8
1.0
1.2
● ● ● ● ●
●●
●
● ● ●
●
●
●
● ● ●
●
0.6
0.8
1.0
1.2
1.4
Ma Breast 4 : primary ductal breast carcinoma
0.5
● ● ● ● ●
● ●
●
● ●
● ●
●
● ●
● ●
0.6
●
●
● ●
●
● ●
●
● ●
● ●
0.4
●●
0.8
●
0.6
●
0.2
●
●
●
● ●
−0.2
●
●
●
●
● ●
● ●
●
●
●
●
1.0
ZBTB7A
● ●
●
●● ● ●
● ●
●
●●
●
●
●
●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
●
●
●
●
−0.6
1.5
●
● ●
MAPK8
●
P−value:0.63; Pearson R:−0.081
Ma Breast 4 : primary ductal breast carcinoma
2.5
BCL6
●
−0.5
0.6
1.4
● ●● ● ● ● ● ● ●
●
●
●
●
BCL6
●
MAPK10
●
●
P−value:0.23; Pearson R:−0.2
● ●
●
1.0
P−value:0.53; Pearson R:0.11
● ●
●
0.2
●
●
−0.2
●
−0.6
●
0.5
MAPK10
1.5
●
● ●
MAPK8
● ●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.87; Pearson R:−0.028
2.5
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●●
●
● ●●
●
●
● ●
● ● ●
● ●
●
●
−0.4
●
●
0.6
●
0.8
1.0
1.2
●
5.5
● ● ●
●
5.0
● ●
●
● ●
●
●
●
● ●
●
●
●
●
● ●
●
●
● ● ●
0.6
0.8
1.0
1.2
1.4
Ma Breast 4 : primary ductal breast carcinoma
●
●
● ●
●
●
●● ●
● ●
−0.2
● ●
● ● ●
● ●
●
● ●
● ●
0.4
0.6
0.8
5.0
●
4.5
0.0
● ●
●
● ● ●● ●
● ●
●
●
● ●
● ●
●
●
●
● ●● ●
4.0
●
●
3.5
●
● ●
●
● ●
● ●
● ●
● ● ●
● ●
● ●
●
● ●
●
3.0
●
SCRIB
●
5.5
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.62; Pearson R:0.082
BCL6
0.2
BCL6
●
−0.4
●
●
● ● ● ● ●
1.4
●
MAPK9
● ●
● ●
1.0
ZBTB7A
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.5; Pearson R:−0.11
●● ●
1.0
P−value:0.068; Pearson R:0.3
●
4.5
●
●
4.0
0.0
● ●
●
−0.2
MAPK9
●
●
3.5
● ●
●
● ●
3.0
●
●
SCRIB
● ●
Ma Breast 4 : primary ductal breast carcinoma
P−value:0.46; Pearson R:0.12
0.2
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
● ●
● ●
● ●
●
●
●
−0.5
●
3.5 3.0
●
●
● ●
●
● ● ●
● ●
●
●
●
●
●
● ● ●
● ●
● ● ●
●
●
● ●
●
●
0.6
●
0.8
1.0
1.2
1.4
0.6
0.8
1.0
1.2
1.4
BCL6
Ma Breast 4 : primary ductal breast carcinoma
Ma Breast 4 : primary ductal breast carcinoma
SRC
● ●
● ● ●
●
●
●
●
● ● ● ●●
●
●● ●
●
●
●
●
●
●
●
●
●
●
●
−0.5
●
●
0.4
0.6
0.8
3.5
● ●
3.0
● ● ●
●
● ●
●
●
● ●●
● ● ● ● ●
● ●
●
● ●
●
●
●
●
● ● ●
2.5
−0.1
● ●
●
● ●
●
●
● ●
●
2.0
●
YES1
0.1
BCL6
●
1.0
ZBTB7A
● ●
0.4
0.6
0.8
ZBTB7A
Biology Open | Supplementary Material
P−value:0.89; Pearson R:−0.023
●
● ●
P−value:0.83; Pearson R:0.036
−0.3
● ● ●
●
● ●
1.0
P−value:0.94; Pearson R:0.012
●
●
●
● ●●
2.5
●
●
●
●
● ●
2.0
●
YES1
●
●
P−value:0.3; Pearson R:0.17
● ●
●
● ●
●
−0.3
Ma Breast 4 : primary ductal breast carcinoma
● ●
SRC
−0.1
0.1
Ma Breast 4 : primary ductal breast carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
● ●●
●
●
●
● ●●
●
●● ●
● ● ●
●
●
●
● ●
●
−0.6
● ●
1.0
1.5
2.0
2.5
3.0
●
●
●
●
● ●
●
● ●● ●
● ●
● ●
● ● ●
●
●
●
● ● ●
●
● ●
●
● ●
●
−0.3 −0.2 −0.1
0.0
0.1
0.2
1.0
1.2
1.4
0.5 0.0
●
●
−0.5
● ●
1.4
−1.0
●
● ●
1.2
1.0
no data
ARHGEF11
0.6
1.0
Rohrbeck Lung : all−Lung
●
0.2
0.8
BCL6
●
−0.2
0.6
BCL6
●
−0.6
0.5
3.5
●
ARHGEF1
0.0
●
● ●●
−0.5
●
● ●
●
●
●
−1.0
●
●
P−value:0.35; Pearson R:0.15
0.2
● ●
●
●
ARHGEF11
●
−0.2
ARHGEF1
0.6
●
P−value:0.033; Pearson R:−0.33
Rohrbeck Lung : all−Lung
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
3.0
0.5
● ●
●
●●
●
2.5
● ●
●●
●
● ● ●
●
2.0
0.0
DLG1
●
●
●
● ●
●●
●
●
● ● ●
●
●
●
●
●
● ●
1.5
−0.5
ARHGEF12
● ●
●
●
1.0
−1.0
● ●
0.8
1.0
1.2
1.4
1.0
1.5
2.0
3.0
BCL6
no data
Rohrbeck Lung : all−Lung
●
3.5 3.0
0.5
3.5
● ●
●
● ●
● ●
●
−0.5
2.5
●
●
●
● ●
●
●
●
●
● ●
●
●
●
1.5
●
● ● ● ●
● ● ●
2.0
0.0
DLG1
●
●
●
●
● ● ●
●
0.6
0.8
1.0
1.2
1.4
● ●
1.0
−1.0
ARHGEF12
2.5
BCL6
1.0
0.6
●
●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
0.0
0.1
P−value:0.0011; Pearson R:0.49
●
P−value:0.047; Pearson R:−0.31
3.5
1.0
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●
●
●
●
● ●
● ●
●
● ● ●
● ●
● ● ●
●
● ●
● ●
● ● ●
1.0
1.5
2.0
2.5
3.0
−0.2
● ●
●● ●
● ●
● ●
●●
●
●
1.5
2.0
2.5
3.0
Rohrbeck Lung : all−Lung
● ●● ●
●
●
●
● ●
●
● ● ● ● ●
●
● ●
● ●
●
● ●
●
●● ●
● ● ●
−0.3 −0.2 −0.1
0.0
0.1
0.2
−0.2
● ●
●
● ●
●
●
●
−0.4
●
●
●
●
● ●●
●
●
●●
● ●
● ●
−0.6
●
●
●
●
3.5
●
●
●
●
● ●● ● ●
●
●
● ●
●
−0.8
●
0.0
Rohrbeck Lung : all−Lung
●
●
● ●
1.0
DLG3
−1.8 −1.6 −1.4 −1.2 −1.0
DLG2
●
BCL6
●
●
● ●
●
BCL6
●
●
● ●● ● ●
●
3.5
●
● ●
●
●
● ●
●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
0.0
0.1
P−value:0.59; Pearson R:−0.085
●
●
● ●
●
●
P−value:0.35; Pearson R:0.15
● ● ●
● ●
●
−0.4
● ●
●
●
●
●
−0.6
●
●
●
−0.8
●
●
●
DLG3
●
●
P−value:0.082; Pearson R:0.27
−1.8 −1.6 −1.4 −1.2 −1.0
DLG2
●
0.0
Rohrbeck Lung : all−Lung
P−value:0.02; Pearson R:−0.36
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ●
●
●
● ●
●
●
●
● ● ● ●
●
●
●
●
● ●● ●
●
●
−1.4
●
●
●
●
1.0
1.5
2.0
●
●
●
2.5
3.0
3
●
●
●
● ●
● ●
●
1.0
1.5
2.0
2.5
3.0
●
●
●
●
●
● ●
●
●
●
● ● ●●
●
● ●
●
● ● ●
●
●
●
●
●
● ●
●
●
−0.3 −0.2 −0.1
0.0
0.1
0.2
3.5
● ●
3
●
● ●
●
2
● ● ●
●
● ● ●
●
● ● ●
●
●
●
1
●
●
●
●
●
●
● ●
●
●
● ●
● ● ●●
●
●
●
● ● ●
● ● ● ●
0
−0.6
●
●
●
Rohrbeck Lung : all−Lung
●
−1.0
●
Rohrbeck Lung : all−Lung
●
−1.4
●
●
BCL6
● ●
DLG4
● ●
BCL6
●
●
●
●
●
●
●
●
●
●● ● ●●
3.5
●
●
●
● ● ● ● ●
FYN
●
●
● ●
●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
0.0
0.1
P−value:0.55; Pearson R:−0.095
●
●
●
2
●
1
●
−1.0
DLG4
●
●
0
●
P−value:0.16; Pearson R:0.22
−0.6
●
● ●
●
FYN
●
P−value:0.11; Pearson R:−0.25
Rohrbeck Lung : all−Lung
P−value:0.086; Pearson R:−0.27
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
● ●
●
0.8
●
●
●
●
●
●
●
●
●
● ●
0.6
●
●
1.0
1.5
2.0
2.5
3.0
●
●
● ●
0.5
●
●
●
●
●
1.0
1.5
2.0
2.5
3.0
● ● ●
●●
● ●
● ●
●
●
● ●
● ●
●
●
● ●
●
●
−0.3 −0.2 −0.1
0.0
0.1
0.2
3.5
●
0.5
● ● ●
●
● ●
●
0.0
●●
●
●
●
●
● ●
●
●
● ●
−0.5
●
●
●
1.0
● ●
●
●
●
● ●
●
● ● ●
●
●
● ● ●
● ●
●
●
●
●
● ● ●
●
●
● ● ●
●
●
●● ●
●
●
●
●
−1.0
1.6 1.4 1.2
●
●
0.8
●
●
●
● ●
●
Rohrbeck Lung : all−Lung
●
0.6
●
●
Rohrbeck Lung : all−Lung
●
LLGL1
●
BCL6
●
● ●
●
BCL6
●
●
●
3.5
●
● ●
●
● ● ●
●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
0.0
0.1
P−value:0.95; Pearson R:−0.0096
●
0.0
● ●
●●
●
● ●●
−0.5
●
●
●
●
●
LLGL2
1.2
● ●
1.0
LLGL1
● ●
●
●
● ●
●
−1.0
●
●
LLGL2
●
P−value:0.22; Pearson R:0.19
1.4
●
P−value:0.6; Pearson R:−0.083
Rohrbeck Lung : all−Lung
P−value:0.0038; Pearson R:−0.44
1.6
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.5 ●
●
●
● ●
● ●
● ● ● ● ● ● ●
●
● ● ●
●
●
● ● ●
● ●
●
●
●●
●
●
1.0
1.5
2.0
2.5
3.0
−1.2
●
●
●
●
●●
●
●
●
●
● ●
●
● ●
● ●
●
●
● ● ●
1.0
1.5
2.0
2.5
3.0
● ● ●
● ● ● ●● ●
● ● ●
●● ● ●
● ● ●●
●
● ● ● ●
● ●
●●
●
●
●
−0.3 −0.2 −0.1
0.0
0.1
●
0.2
−1.2
● ●
●
● ●
●
●
●
●
●
● ●
● ● ●
●
● ●
●
●
●
●
●
●
● ●
●
●●
●
● ●
●
● ● ● ●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
3.5
●
●
●
●
−1.4
●
−1.6
●
●
−1.8
1.0 0.5
●
Rohrbeck Lung : all−Lung
●
0.0
●
●
Rohrbeck Lung : all−Lung
●
−0.5
●
BCL6
●
MAP2K4
● ● ●
● ●
BCL6
●
●
●
3.5
●
●
● ●
●
MAP2K7
●
P−value:0.065; Pearson R:−0.29
0.0
●
−0.5
MAP2K4
●
●
0.0
0.1
P−value:0.15; Pearson R:0.22
● ● ●
●
●
● ● ●
−1.4
●
●
−1.6
●
−1.8
1.0
●
●
MAP2K7
●
P−value:0.00062; Pearson R:−0.51
Rohrbeck Lung : all−Lung
P−value:0.0025; Pearson R:0.45
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●● ●
● ●
● ●
● ●
●
● ●
● ●
●
●
●
● ● ●
●
●
● ●
● ●
●
1.5
2.0
2.5
3.0
●
●
●
● ●
● ●
●
●
●
●
−0.5
1.0
1.5
2.0
2.5
3.0
● ●
●
● ● ●
●
●
● ● ● ●
●
●
●
●
●
●
● ● ●
● ●
●
●
●
● ●
● ●
−0.3 −0.2 −0.1
0.0
0.1
●
0.2
−0.5
● ● ●
●
●
● ● ●
−0.7
●
●
3.5
● ●
MAPK8
0.8
●
●
P−value:0.42; Pearson R:0.13
1.2
Rohrbeck Lung : all−Lung
●
0.4
●
●
●●●
Rohrbeck Lung : all−Lung
●
0.0
●
● ●
BCL6
●
MAPK10
●
BCL6
●
●
●
3.5
●
●
●
●
● ●
● ●
●
●
1.0
●
●
●
● ● ● ●
●
●
● ● ●
● ●
● ●
● ●
●
●● ●
● ●
● ●
●
●
−0.9
0.0
● ●
●
● ●
−1.1
●
●
● ● ●
−0.7
●
●
●
−0.9
●
●
−1.1
●
●
0.4
MAPK10
0.8
●
●
MAPK8
●
P−value:0.4; Pearson R:0.13
●
● ●● ●
●
●
●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
0.0
0.1
P−value:0.1; Pearson R:−0.25
Rohrbeck Lung : all−Lung
P−value:0.11; Pearson R:0.25
1.2
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
● ●
● ●
●
●
● ●
●
●●
●
●
● ● ●
●
●
●
●
●●
●
●
●
●
●
● ●
●
●
●
1.0
1.5
2.0
2.5
3.0
●
● ● ●
●
● ●
●
●
● ● ●
● ●
●
● ●
● ●
−0.3 −0.2 −0.1
0.0
0.1
0.2
1.0
1.2
1.4
0.5 0.0
●
●
−0.5
● ●
●
●
1.4
−1.0
●
●
SCRIB
2.0 1.5 1.0
● ●
●
0.5
MAPK9
● ●
● ●
1.2
1.0
no data
●
●
1.0
Rohrbeck Lung : all−Lung
●
●
0.8
BCL6
●
●
0.6
BCL6
●
●
0.5
3.5
P−value:0.64; Pearson R:−0.073
0.5
● ●
0.0
●
●
−0.5
1.5
● ● ●
1.0
MAPK9
●
−1.0
2.0
●
SCRIB
●
P−value:0.27; Pearson R:0.18
Rohrbeck Lung : all−Lung
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ●
●
● ● ●
●
0.4
●
●
● ● ● ●● ● ●
●
●
●
● ●
● ●
●
●
1.0
1.5
2.0
2.5
●
2.5
●
● ●
●
●
●
●
● ●
1.5
2.0
2.5
3.0
●
0.8
● ●
●
● ●
● ● ●
●
●
● ● ● ● ●
●
●●
●
●
● ●
● ●●
●
● ●
● ●
−0.3 −0.2 −0.1
0.0
0.1
●
0.2
3.5
2.5
● ●
1.5
● ●
●
●
●
●
1.0
●
●
● ● ●
● ●
0.5
●
●
●
●
●● ●
● ●
● ●
● ●
● ● ●
●
●
●
●
●
● ● ●
● ●
●
●
●
●
●
●
● ●
−0.5
●
●
0.6
●●
●
●
● ● ●
Rohrbeck Lung : all−Lung
●
0.4
●● ●
●●
● ●●
Rohrbeck Lung : all−Lung
●
●
●
BCL6
●
SRC
●
3.5
●
●
●
● ● ●
BCL6
1.2 1.0
3.0
●
● ●
−0.3 −0.2 −0.1
ZBTB7A
ZBTB7A
Biology Open | Supplementary Material
0.0
0.1
P−value:0.0096; Pearson R:0.4
●
YES1
0.8
●
● ●
0.6
SRC
● ●
P−value:0.83; Pearson R:0.033
●
●
1.5
●
0.5
●
●
● ●
−0.5
● ●
YES1
●
P−value:0.12; Pearson R:−0.24
Rohrbeck Lung : all−Lung
P−value:0.55; Pearson R:0.096
1.0
1.2
Rohrbeck Lung : all−Lung
0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
1.6
● ●
●
●
●
● ●
●
●
1.4
●
●
0.6
0.8
1.0
●
● ● ●
● ●
●
●
● ● ● ● ● ● ●
1.2
0.6
●
0.8
1.0
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
1.7
● ● ●
● ● ●
●
●
●
1.5
●
●
●
1.4
●
●
−0.8
−0.6
−0.4
−0.2
−1.0 −0.8 −0.6 −0.4 −0.2
●
● ●
1.2
●
ARHGEF11
●
P−value:0.79; Pearson R:0.063
BCL6
●
1.6
●
BCL6
●
ARHGEF1
●
● ●
● ●
● ● ●
●
●
●
●
●
●
● ● ● ●
−0.8
ZBTB7A
● ●
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.53; Pearson R:−0.15
●
●
P−value:0.98; Pearson R:0.0055
1.7
● ●
1.5
ARHGEF1
●
●
●
●
−1.0 −0.8 −0.6 −0.4 −0.2
●
●
ARHGEF11
●
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.25; Pearson R:0.27
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
● ●
●
0.8
1.0
●
● ●
●●
●
● ●
● ●
0.1
●
1.2
0.6
0.8
1.0
BCL6
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
● ●
●
● ●
● ●
● ● ●
●
● ●
●
● ●
●
−0.8
−0.6
−0.4
−0.2
0.1
● ● ● ● ●
0.0
● ●
1.2
● ●
●
−0.1
●
−0.2
−2.3 −2.2 −2.1 −2.0 −1.9
ARHGEF12
0.6
●
●
DLG1
●
● ●
●
● ●
●
●
●
● ●
● ● ● ●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.89; Pearson R:−0.034
●
● ●
●
P−value:0.75; Pearson R:0.077
●
●
●
0.0
●
● ●
●
●
−0.1
●
●
−0.2
●
●
DLG1
●
P−value:0.76; Pearson R:0.074
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.83; Pearson R:0.05
−2.3 −2.2 −2.1 −2.0 −1.9
ARHGEF12
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ● ●
●
●
●
−1.7
● ●
0.6
0.8
1.0
2.2 1.8
●
●
●
●
●
●
●
● ●
●
0.6
0.8
1.0
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
−1.5
● ●
● ● ●
●
● ●
● ●
●
● ●
−0.8
−0.6
−0.4
−0.2
2.2
● ●
1.8
● ● ● ●
1.4
●
●
● ●●
●
● ● ● ●
●
● ●
1.0
●
1.2
●
DLG3
−1.3
● ●
P−value:0.061; Pearson R:0.43
BCL6
●
−1.7
● ● ●
●
1.2
●
DLG2
● ●
●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.28; Pearson R:0.25
● ●
●
● ●
1.4
● ● ●
●
1.0
● ●
●
DLG3
●
−1.5
DLG2
−1.3
●
P−value:0.74; Pearson R:0.081
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.35; Pearson R:−0.22
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ●
●
●
−0.3
●
●
●
0.6
0.8
1.0
0.5 0.3
●
●
●
●●
●
●
●
●
● ● ● ●
0.6
0.8
1.0
BCL6
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
●
● ●
●
●●
●
●
●
−0.3
●
●
●
−0.8
−0.6
−0.4
−0.2
0.5
●
●
0.3
●
1.2
●
●
● ●
0.1
0.1
● ●
●
●
● ●
●
● ● ●
● ●
●
−0.1
●
FYN
0.3
● ●
−0.1
●
1.2
●
DLG4
●
● ● ●
−0.8
ZBTB7A
●
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.062; Pearson R:0.42
0.1
●
●
−0.1
DLG4
●
● ● ●
0.1
●●
●
●
−0.1
●
●
FYN
●
P−value:0.81; Pearson R:0.057
0.3
●
P−value:0.12; Pearson R:−0.36
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.33; Pearson R:−0.23
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ●
0.9
● ●
● ●
0.6
0.8
1.0
2.1
● ●
●
●
● ●
●
●
●
●
1.2
0.6
0.8
1.0
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
● ●
● ●
● ●
0.9
● ●
● ●
−0.8
−0.6
−0.4
−0.2
2.1 1.9
●
● ●
●
● ●
●
● ●
●
1.7
1.3
●
●
●
●
●
● ●
●
●
●
1.5
1.5
● ●
1.2
●
LLGL2
● ●●
P−value:0.25; Pearson R:0.27
BCL6
●
1.1
●
BCL6
●
LLGL1
● ●
●
●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.037; Pearson R:−0.47
●
●
P−value:0.018; Pearson R:0.52
1.3
●
●
1.1
LLGL1
●
● ●
●
1.9
●
1.7
● ●
● ●
1.5
● ●
LLGL2
1.5
● ●
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.18; Pearson R:0.31
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●●
●
●
●
● ● ● ●
0.6
0.8
1.0
0.6 0.4
●
●
●
●
● ●
●
0.6
0.8
1.0
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
● ●
● ● ● ●
2.4
● ● ●
● ●
● ● ●
−0.8
−0.6
−0.4
−0.2
0.6
●
0.4
●
●
●
●
● ●
0.2
2.8
●
1.2
●
●
● ● ●
●
● ●
● ●
●
0.0
3.0
●
●
●
BCL6
●
2.6
●
1.2
●
MAP2K4
● ●
●
MAP2K7
2.4
●
●
●
● ●
● ●
●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.12; Pearson R:0.36
●
●
● ●
0.2
●
● ●
0.0
●
P−value:0.72; Pearson R:−0.084
2.8
● ●
2.6
MAP2K4
●
MAP2K7
3.0
● ●
P−value:0.75; Pearson R:−0.076
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.13; Pearson R:−0.35
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●
●
●
● ● ●
0.8
1.0
0.9 0.8 0.7
● ● ●
● ● ● ● ●
● ●
1.2
0.6
0.8
1.0
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
● ●
● ● ● ●
● ●
● ●
● ● ●
−0.8
−0.6
−0.4
−0.2
●
0.8
●
●
●
0.7
● ●●
●
●
● ● ●
0.6
●
●
1.2
●
● ●
● ● ●
0.5
●
MAPK8
●
0.9
BCL6
●
P−value:0.4; Pearson R:0.2
●
●
−0.5 −0.4 −0.3 −0.2 −0.1
●
● ●
●
● ●
●
P−value:0.3; Pearson R:0.25
● ●
●
●
0.6
●
●
0.5
● ●
●
●
MAPK8
● ●
0.6
MAPK10
●
P−value:0.47; Pearson R:0.17
−0.5 −0.4 −0.3 −0.2 −0.1
MAPK10
●
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.92; Pearson R:0.024
Skrzypczak Colorectal 2 : all−Epithelia
●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
● ●
● ●
●
3.0
●
●
0.6
0.8
1.0
● ●
●
●
●
●
● ● ●
●
●
●
● ●
1.2
0.6
0.8
1.0
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
●
●
3.2
● ●
●
●
●
● ●
● ●
●
3.0
●
●
−0.8
−0.6
−0.4
−0.2
4.2
●
●
●
● ● ●
●●
●
● ●
3.8
●
●
●
● ●
●●
3.4
3.6
●
●
1.2
●
SCRIB
●
3.4
● ●
BCL6
●
MAPK9
● ●
● ●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.96; Pearson R:−0.013
●
P−value:0.011; Pearson R:0.55
3.4
●
●
3.2
MAPK9
●
●
4.2
●
3.8
●
●
3.4
3.6
●
SCRIB
●
P−value:0.79; Pearson R:−0.062
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.14; Pearson R:−0.34
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
● ●
● ●
−0.1
●
●
1.0
6.0
●
● ●
●
●
0.6
0.8
1.0
BCL6
Skrzypczak Colorectal 2 : all−Epithelia
Skrzypczak Colorectal 2 : all−Epithelia
●
●
●
●
●
●
● ●
●
● ●
● ●
●
−0.8
−0.6
−0.4
−0.2
● ●
●
5.5
● ●
● ●
●
●
●
● ●
●
●
5.0
● ●
1.2
● ●
● ●●
4.5
●
6.0
BCL6
●
●
●
1.2
YES1
0.1 0.2 0.3 0.4
0.8
−0.1
SRC
0.6
●
● ●
●
●
−0.8
ZBTB7A
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.4
P−value:0.82; Pearson R:−0.054
●
●
●
●
P−value:0.016; Pearson R:0.53
●
●
●
●
5.5
●
● ●
5.0
● ●
●
●
●
4.5
●
● ●
YES1
●
●
P−value:0.28; Pearson R:−0.26
Skrzypczak Colorectal 2 : all−Epithelia
P−value:0.89; Pearson R:0.033
0.1 0.2 0.3 0.4
SRC
Skrzypczak Colorectal 2 : all−Epithelia
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
1.5
●
●
0.5
0.6
0.7
0.8
0.9
1.0
−0.2
● ●
● ●
● ●
●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
BCL6
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
●
1.4
1.5
●
●
−0.6
−0.5
−0.4
−0.3
−0.2
−0.2 −0.4
●
● ●
−0.6
1.6
● ●
●
●
● ●
−0.8
1.7
● ●
1.1
●
ARHGEF11
●
P−value:0.27; Pearson R:−0.38
BCL6
●
ARHGEF1
●
●
●
●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.13; Pearson R:−0.51
●
−0.4
●
●
−0.6
1.6
●
●
−0.8
●
1.4
ARHGEF1
1.7
●
●
ARHGEF11
● ●
P−value:0.53; Pearson R:0.22
Skrzypczak Colorectal 2 : normal
P−value:0.96; Pearson R:−0.021
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−2.3
● ●
0.6
0.8
0.9
1.0
0.1 0.0
● ●
●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
BCL6
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
−2.1
●
−2.2
● ●
−2.3
● ●
−0.6
−0.5
−0.4
−0.3
−0.2
0.1
●
●
0.0
●
●
●
−0.1
●
●
−0.2
● ●
1.1
●
DLG1
●
P−value:0.074; Pearson R:−0.59
BCL6
−1.9 −2.0
0.7
●
P−value:0.78; Pearson R:0.1
●
●
●
● ●
●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.75; Pearson R:−0.11
●
●
−0.1
−2.1
●
●
●
−0.2
●
●
●
DLG1
●
●
P−value:0.18; Pearson R:0.46
−2.0
●
0.5
ARHGEF12
Skrzypczak Colorectal 2 : normal
●
−2.2
ARHGEF12
−1.9
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
Skrzypczak Colorectal 2 : normal
−1.5
● ●
●
0.6
0.7
0.8
0.9
1.0
2.2 1.8 ●
●
0.5
0.6
0.7
0.8
0.9
1.0
BCL6
BCL6
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
● ●
−1.5
● ●
●
−0.6
−0.5
●
−0.4
−0.3
−0.2
2.2
● ●
1.8
● ● ● ●
1.4
●
●
●
1.0
−1.3 −1.4
●
1.1
●
DLG3
●
●
DLG2
●
1.1
P−value:0.81; Pearson R:−0.085
−1.2
0.5
●
●
P−value:0.14; Pearson R:0.5
●
● ●
●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.61; Pearson R:−0.19
●
● ●
1.4
●
●
1.0
●
−1.4
DLG2
−1.3
●
●
DLG3
●
P−value:0.97; Pearson R:0.012
−1.2
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−0.2
●
●
0.5
0.6
0.7
0.8
0.9
1.0
0.5 0.4 0.3 ● ●● ● ●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
0.0
●
●
−0.2
●
●
−0.6
−0.5
−0.4
−0.3
−0.2
0.5 0.4 0.3
●
●
0.2
●
● ●
●
0.1
0.2
●
● ●
1.1
●
FYN
●
P−value:0.38; Pearson R:−0.31
BCL6
0.4
BCL6
●
DLG4
●
●
● ● ●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.89; Pearson R:0.051
●
P−value:0.74; Pearson R:0.12
●
●
0.2
● ●
● ●
0.1
●●
0.0
DLG4
0.2
●
●
FYN
●
P−value:1; Pearson R:0.00037
Skrzypczak Colorectal 2 : normal
0.4
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
0.5
0.6
0.7
0.8
1.0
2.0
2.1
●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
●
1.1
●
1.0
●
●
●
−0.6
−0.5
−0.4
−0.3
−0.2
2.1 2.0
●
●
1.9
1.2
●
●
●
●
● ●
●
1.8
1.3
●
1.1
●
1.7
●
LLGL2
●
P−value:0.19; Pearson R:0.45
BCL6
1.4
BCL6
●
LLGL1
0.9
● ●
●
P−value:0.18; Pearson R:−0.46
1.0
●
● ●
●
P−value:0.5; Pearson R:0.24
1.1
●
●
1.9
●
1.8
1.3 1.2
●
● ●
1.7
●
LLGL2
● ● ●
LLGL1
Skrzypczak Colorectal 2 : normal
P−value:0.59; Pearson R:0.19
1.4
Skrzypczak Colorectal 2 : normal
●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ●
2.4
●
●
0.5
0.6
0.7
0.8
0.9
1.0
● ●
●
●
●
●
● ●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
BCL6
BCL6
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
●
● ● ●
2.4
●
●
−0.5
−0.4
−0.3
−0.2
0.1 0.2 0.3 0.4 0.5 0.6
2.6
●
MAP2K7
●
P−value:0.5; Pearson R:0.24
3.0 2.8
●
−0.6
1.1
●
●
MAP2K4
●
●
● ●
●
●
●
● ● ●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.77; Pearson R:−0.11
●
0.1 0.2 0.3 0.4 0.5 0.6
●
●
MAP2K7
2.8
●
2.6
MAP2K4
3.0
●
P−value:0.67; Pearson R:0.15
Skrzypczak Colorectal 2 : normal
P−value:0.17; Pearson R:−0.47
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
0.6
0.7
0.8
0.9
1.0
0.9 0.8 0.7
●
● ●
●
●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
BCL6
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
●
● ●
● ●
−0.6
−0.5
−0.4
−0.3
−0.2
0.8 0.7
●
●
●
●
●
●
●
●
0.6
●
1.1
●
●
●
0.5
−0.5 −0.4 −0.3 −0.2 −0.1
●
MAPK8
●
0.9
BCL6
●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.094; Pearson R:0.56
●
●
●
P−value:0.79; Pearson R:0.099
●
●
●
0.6
●
●
0.5
●
MAPK8
● ●
0.5
MAPK10
●
P−value:0.86; Pearson R:−0.066
−0.5 −0.4 −0.3 −0.2 −0.1
MAPK10
●
Skrzypczak Colorectal 2 : normal
P−value:0.65; Pearson R:0.16
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
3.3
●
3.1
●
●
0.5
0.6
0.7
0.8
1.0
4.2
●
● ●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
3.3
●
●
●
●
−0.6
−0.5
−0.4
−0.3
−0.2
4.2
●
● ●
3.8
3.5
●
●
● ●
●
3.4
●
1.1
●
SCRIB
3.7
● ●
P−value:0.068; Pearson R:0.6
BCL6
●
3.1
●
BCL6
●
MAPK9
0.9
● ●
● ●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.59; Pearson R:−0.19
●
●
● ●
P−value:0.49; Pearson R:0.25
●
●
3.8
3.5
●
●
3.4
●
SCRIB
3.7
●
●
MAPK9
Skrzypczak Colorectal 2 : normal
P−value:0.44; Pearson R:−0.28
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−0.1
●
●
0.7
0.8
0.9
1.0
5.9 5.8
●
●
1.1
0.5
0.6
0.7
0.8
0.9
1.0
BCL6
BCL6
Skrzypczak Colorectal 2 : normal
Skrzypczak Colorectal 2 : normal
● ●
● ●
● ●
●
−0.6
−0.5
−0.4
−0.3
−0.2
5.9
●
● ●
5.8
●
1.1
●
● ●
5.7
●
●
● ●
5.6
●
YES1
0.1 0.2 0.3 0.4
0.6
−0.1
SRC
0.5
●
●
●
−0.6
ZBTB7A
−0.5
−0.4 ZBTB7A
Biology Open | Supplementary Material
−0.3
P−value:0.8; Pearson R:0.094
● ●
●
P−value:0.39; Pearson R:−0.31
●
● ●
5.7
●
● ●
●
5.6
●
●
YES1
●
●
P−value:0.9; Pearson R:−0.047
Skrzypczak Colorectal 2 : normal
P−value:0.72; Pearson R:−0.13
0.1 0.2 0.3 0.4
SRC
Skrzypczak Colorectal 2 : normal
−0.2
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
−0.4 −0.6
● ●
0.5
0.6
0.7
0.8
●
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
Skrzypczak Colorectal 2 : colon adenoma
1.55
●
●
● ●
−0.85
−0.75
−0.65
−0.55
−0.4 −0.6
●
●
● ●
−0.8
1.65
●
●
● ●
−1.0
●
●
ARHGEF11
1.75
●
−0.2
BCL6
P−value:0.18; Pearson R:0.46
BCL6
●
1.45
● ●
1.2
●
ARHGEF1
●
● ●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
P−value:0.2; Pearson R:−0.45
●
●
●
●
−0.55
P−value:0.92; Pearson R:−0.037
1.55
●
●
−0.8
1.65
●
●
1.45
ARHGEF1
●
●
−1.0
●
●
ARHGEF11
1.75
●
−0.2
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.099; Pearson R:0.55
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.5
0.6
0.7
0.8
0.9
1.0
1.1
0.05 −0.05 0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
●
●
●
−0.85
−0.75
−0.65
−0.55
0.05 −0.05
−2.15
●
●
●
● ●
●
−0.15
● ●
●
●
●
−0.25
●
DLG1
−2.05
Skrzypczak Colorectal 2 : colon adenoma
●
−2.25
●
BCL6
●
−2.35
●
BCL6
●
ARHGEF12
●●
●
1.2
P−value:0.16; Pearson R:0.48
−2.15 −2.25
●
●
● ●
● ●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
−0.55
P−value:0.77; Pearson R:−0.11
●
●
−2.35
ARHGEF12
●
●
−0.15
●
● ●
−0.25
●
●
DLG1
● ●
P−value:0.67; Pearson R:−0.15
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.32; Pearson R:−0.35
−2.05
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.5 1.4 1.3
●
1.2
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
Skrzypczak Colorectal 2 : colon adenoma
● ● ●
●
●
● ●
−0.85
−0.75
−0.65
−0.55
●
1.5
●
1.4
● ●
●
1.3
● ●
●
1.2
●
●
1.1
●
DLG3
−1.5
−1.4
●
1.6
BCL6
−1.3
BCL6
−1.6
DLG2
● ●
●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
P−value:0.024; Pearson R:−0.7
●
●
● ●
●
−0.55
P−value:0.79; Pearson R:0.097
●
●
1.2
● ●
● ●
1.1
−1.6
●
DLG3
●
P−value:0.55; Pearson R:0.21
−1.5
DLG2
−1.4
●
1.6
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.21; Pearson R:−0.43
−1.3
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
−0.3
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
0.3 0.2
● ● ●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
BCL6
Skrzypczak Colorectal 2 : colon adenoma
Skrzypczak Colorectal 2 : colon adenoma
●
−0.3
●
●
−0.85
−0.75
−0.65
−0.55
0.3 0.2 0.1
● ●
●
● ● ●
−0.1 0.0
●
●
FYN
0.2
●
0.1 −0.1 0.0
●
●
1.2
●
DLG4
●
BCL6
●
●
●
●
● ● ● ● ●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
P−value:0.0069; Pearson R:−0.79
●
−0.55
P−value:1; Pearson R:−0.0018
● ●
●
0.1
−0.1 0.0
DLG4
0.1
●
−0.1 0.0
●
●
FYN
●
●
P−value:0.22; Pearson R:−0.42
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.9; Pearson R:0.046
0.2
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
●
●
●
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
●
1.3
1.5
●●
●
0.9
●
●
● ●
−0.85
−0.75
−0.65
−0.55
1.5 1.6 1.7 1.8 1.9 2.0
Skrzypczak Colorectal 2 : colon adenoma
LLGL2
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.2; Pearson R:0.45
BCL6
●
1.1
● ●
BCL6
●
LLGL1
●
● ●
●
● ●
●
●
●
●
●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
P−value:0.15; Pearson R:−0.49
●
● ●
−0.55
P−value:0.13; Pearson R:0.51
●
●
1.5 1.6 1.7 1.8 1.9 2.0
1.3 1.1
●
LLGL2
● ●
●
0.9
LLGL1
1.5
● ●
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.27; Pearson R:0.38
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
0.3 0.2 0.1
● ●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
Skrzypczak Colorectal 2 : colon adenoma
●
●
●
2.4
● ●
●
−0.85
−0.75
−0.65
−0.55
0.3 0.2
●
●
0.1
●
●
0.0
●
●
●
●
−0.1
●
●
MAP2K7
●
P−value:0.096; Pearson R:−0.55
BCL6
3.0
BCL6
2.8 2.6
●
●
1.2
●
MAP2K4
●
●
−0.85
ZBTB7A
●
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
−0.55
P−value:0.68; Pearson R:0.15
●
●
● ●
0.0
2.8 2.6
●●
2.4
MAP2K4
●
●
−0.1
● ●
●
MAP2K7
●
P−value:0.49; Pearson R:−0.25
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.5; Pearson R:−0.24
3.0
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
0.8 0.7
● ●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
Skrzypczak Colorectal 2 : colon adenoma
● ●
●
●
−0.85
−0.75
−0.65
−0.55
0.8 0.7
● ● ● ● ●
0.6
●
●
● ●
0.5
●
●
MAPK8
−0.30
● ●
P−value:0.91; Pearson R:0.039
BCL6
●
−0.35
●
BCL6
−0.40 −0.45
●
1.2
●
MAPK10
●
●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
−0.55
P−value:0.29; Pearson R:0.37
●
● ●
0.6
−0.35
●
●
0.5
● ●
●
MAPK8
●
−0.45
−0.40
MAPK10
−0.30
●
P−value:0.65; Pearson R:−0.17
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.63; Pearson R:−0.18
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
2.9
●
0.6
0.7
0.8
0.9
1.1
4.3 4.2 4.1
●
●
●
1.2
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
● ●
3.0
●
●
−0.85
−0.75
−0.65
−0.55
4.2 4.1
●
●
●
4.0
●
●
● ●
●
3.9
3.2
●
●
●
3.8
●
SCRIB
●
4.3
Skrzypczak Colorectal 2 : colon adenoma
●
3.1
●
BCL6
2.9
MAPK9
1.0
●
BCL6
3.3
3.4
0.5
●
P−value:0.7; Pearson R:0.14
●
●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
●
−0.55
P−value:0.65; Pearson R:−0.16
● ●
4.0
3.1
●
3.9
●
●
●
3.8
● ●
SCRIB
●
P−value:0.23; Pearson R:−0.42
3.2
3.3
●
3.0
MAPK9
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.12; Pearson R:−0.53
3.4
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
−0.05
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
5.0
●
●
0.5
0.6
0.7
0.8
0.9
1.0
1.1
1.2
Skrzypczak Colorectal 2 : colon adenoma
●
● ●
−0.05
●
●
−0.85
−0.75
−0.65
−0.55
●
5.0
●
● ●
●
●
4.8
0.15
●
●
4.6
●
●
●
YES1
●
5.2
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.94; Pearson R:−0.027
BCL6
0.25
BCL6
●
0.05
● ●
●
1.2
●
SRC
●
●
−0.85
ZBTB7A
−0.75
−0.65
ZBTB7A
Biology Open | Supplementary Material
P−value:0.84; Pearson R:0.072
●
●
●
−0.55
P−value:0.6; Pearson R:−0.19
●
●
4.8
0.15
●
0.05
SRC
●
●
●
4.6
●
YES1
●
5.2
Skrzypczak Colorectal 2 : colon adenoma
P−value:0.075; Pearson R:−0.59
0.25
Skrzypczak Colorectal 2 : colon adenoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
● ● ●
●
●
●
●
●
● ● ●
●
●
−2
●
●
−1
0
1
2
●
1
● ● ●
2
−2
−1
1
●
● ●
●
●
●
0
1
●
●
●
● ●
●
● ●
● ●
● ●
−2
●
−0.5
0.0
0.5
1.0
2
2
●
1
●
●
0
● ●
Tomlins Prostate : all
●
−1
● ● ● ● ● ●
●
●
● ● ● ●
Tomlins Prostate : all
●
ARHGEF1
● ●
●●
BCL6
●
−1.5
●
●
●
● ●
BCL6
●
●
●●
●
● ● ● ●
0
−2
●
●
● ●
●
●
●
●
● ●
●
●
●
●
●
● ●
−1
●
●
●
● ●
−2
●
●
●
● ●● ●●
●
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.87; Pearson R:0.037
●
●
ARHGEF11
0
●
●
●
●
−1
ARHGEF1
●
P−value:0.58; Pearson R:−0.11
1
●
●●
●
0
● ●
●
●
−1
● ●
●
−2
●
ARHGEF11
●
P−value:0.0056; Pearson R:0.45
Tomlins Prostate : all
P−value:0.65; Pearson R:0.069
Tomlins Prostate : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ● ● ●
●
● ●
−1
0
1
●
●
●
● ●
●
● ●
−2
−1
0
● ● ● ●
−0.5
●
●
−0.5
0.0
0.5
1.0
2
●
●
0.5
0.5
●
●
1.0
Tomlins Prostate : all
P−value:0.88; Pearson R:0.056
Tomlins Prostate : all
●
●
1
BCL6
−1.5
ARHGEF12
● ● ●
BCL6
●
−1.5
1.0
2
1.5
−2
● ●
●
●
0.0
−1.5
●
P−value:0.96; Pearson R:0.012
●
●
● ●
P−value:0.037; Pearson R:0.74
● ●
●
0.0
●
●
●
●
●
●
●
−1.0 −0.5
●
●
●
DLG1
0.5
●
●
−0.5
ARHGEF12
● ●
●
−1.0 −0.5
●
DLG1
1.5
● ●
●
0.5
Tomlins Prostate : all
P−value:0.67; Pearson R:0.087
Tomlins Prostate : all
●
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
P−value:0.91; Pearson R:0.029
●
● ●
●
● ● ●
● ●
●
●
−0.5
●
−1.0
−1.0
●
0.8
1.0
1.2
1.4
● ●
−2
−1
0
1
BCL6
BCL6
no data
Tomlins Prostate : all
●
1.0
1.0
0.5
●
●
● ●
●
0.0
DLG3
0.5 0.0
2
● ●●
●
●
−0.5
●
−1.0
●
−1.0
DLG2
●
1.5
0.6
●
0.6
0.8
1.0
1.2
1.4
●
● ●
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.82; Pearson R:0.062
0.5
●
0.0
DLG3
0.5 0.0
DLG2
●
1.0
1.0
1.5
Tomlins Prostate : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
−3
●
−1
0
1
●
●
●●
● ● ●
● ●
● ●
−2
−1
0
●
●
● ●
● ●
1
●
● ●
−3
−2
●
−0.5
0.0
0.5
1.0
2
● ●
0.5
1
● ●
● ● ●●
●
●
●
● ●
● ●
−0.5
● ●
●
●
●
●
● ●
−1.5
●
●
●
Tomlins Prostate : all
●
●
●
● ● ● ● ●
Tomlins Prostate : all
●
0
●
●
●
BCL6
●
−1
● ●
●
2
●
DLG4
● ● ●
●
BCL6
●●
−1.5
●
●
FYN
−2
P−value:0.53; Pearson R:0.15
−1
● ●
−2
DLG4
● ● ●
● ●
●
●
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.0066; Pearson R:0.6
0
●●
●
0.5
● ● ● ●
● ●
−0.5
●
●
−1.5
● ●
FYN
1
● ● ●
P−value:0.55; Pearson R:0.1
Tomlins Prostate : all
P−value:8.6e−05; Pearson R:0.69
Tomlins Prostate : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ●
●
● ● ●
●
● ●
● ●
●
●
●
●
●
−1
●
● ●
●
−1
0
1
0
●
●
●
−2
●
●
−0.5
0.0
0.5
1.0
1.2
1.4
0.5
1.0
2
0.0
● ●
●
●
1
−0.5
●
●
●
−1.0
● ●
LLGL2
●
● ● ● ● ● ● ●
P−value:0.15; Pearson R:0.28
0
● ●
−1
−1
no data
●
LLGL1
−2
Tomlins Prostate : all
●
●
●
●
BCL6
●
●
●
BCL6
●
−1.5
●
●
●
2
1
−2
1
● ●●
●
● ●
0
0
●
●
−2
LLGL1
●●
●
−1
●
● ● ●
LLGL2
1
P−value:0.16; Pearson R:0.23
●
P−value:0.078; Pearson R:0.62
Tomlins Prostate : all
2
Tomlins Prostate : all
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●● ●
●
● ●
●
●
●
●
●
● ●
● ●
●
−2
●
−1
0
1
●
0.5
● ●
●
−2
−1
0
1
● ●
● ●
●
●
●
●
●
● ● ●
●
●
● ● ● ●
−0.5
0.0
0.5
1.0
1.5
2
0.5
● ●
●
● ●
●
●
●
● ● ●
●
● ●
−0.5
1
● ● ●
● ●
●
● ● ● ● ●
−1.5
●
●
0
●
● ●● ●
Tomlins Prostate : all
●
−1
●
Tomlins Prostate : all
●
−2
●
●
●
●
● ●●
● ●
●
BCL6
●
MAP2K4
●
●
BCL6
●
−1.5
●
● ●
2
2
−2
● ● ●●
●
● ●
MAP2K7
−1
●
P−value:0.64; Pearson R:0.08
●
● ●
●
●
●
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.57; Pearson R:−0.13
●
●
●
−0.5
●● ●
● ●
●
●
−1.5
●
●
●
●
●
P−value:0.44; Pearson R:0.16
●
●
●
0
MAP2K4
1
● ● ●
MAP2K7
2
● ●
1.5
Tomlins Prostate : all
P−value:0.58; Pearson R:−0.083
Tomlins Prostate : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●●
●
●
●
●
●
● ● ●
●
●
−2
●
●
●
−3
●
−1
0
1 0
●
−2
−1
●
● ●
●● ●
0
1
0
●
● ● ● ●
−2
●
●
−3
●
−0.5
0.0
●
0.5
1.0
2
1
●
●
0
●
●
●
●
● ●
●
−1
1
●
●
−1
●
●
●
−2
●
●
−1.5
●
● ● ●
Tomlins Prostate : all
●
●
●
●
Tomlins Prostate : all
●
●
● ●
●
2
●
●
●
●
BCL6
●
MAPK10
1
● ●●
BCL6
2
−2
●
●
P−value:0.68; Pearson R:−0.16
●
●
● ●
●
−1
●
● ●
●
●
●
−2
●
● ●
MAPK8
0
●
●●
● ● ●●
●
● ●
−1
MAPK10
1
● ●
●
●
●
●
●
MAPK8
●
●
P−value:0.92; Pearson R:0.021
2
●
P−value:0.02; Pearson R:0.46
Tomlins Prostate : all
P−value:0.92; Pearson R:−0.016
Tomlins Prostate : all
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
● ●● ●
● ●
●
●
●●
●
●
● ●
● ●
● ●●
●
●
−1
0
1
0.0
●
●
●
● ●
●
●
● ● ●
●
● ●
●
−2.0
●
−0.5
0.0
0.5
1.0
1.0
1.4
1.2
1.4
0.5
1.0
● ● ●
1.2
1.0
no data
●
−1.0
1.0
Tomlins Prostate : all
●
MAPK9
0.8
BCL6
●
−1.5
0.6
BCL6
●
●
0.5
2
0.0
−2
−0.5
−2.0
● ●
−1.0
●
●●
●
SCRIB
0.0
● ●
−1.0
MAPK9
●
●
0.0
● ●
●
−0.5
●
●
P−value:0.54; Pearson R:−0.13
1.0
● ●
●
−1.0
●
SCRIB
P−value:0.92; Pearson R:−0.017
Tomlins Prostate : all
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
P−value:0.77; Pearson R:−0.059
●
0.5
●
● ●
● ●
0.0
YES1
0.0
SRC
0.5
1.0
●
●
●
●
●●
●
●
−0.5
●●
●
●
●
●
−1.0
−1.0
●●
0.8
1.0
1.2
1.4
●● ●
−2
●
−1
0
1
BCL6
BCL6
no data
Tomlins Prostate : all
1.0
0.6
●
2
● ●
0.0
0.0
YES1
0.5
●
●
●
● ● ●
−0.5
● ●
●
−1.0
●
−1.0
SRC
0.5
1.0
●
0.6
0.8
1.0
1.2
1.4
● ●
−1.5
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.79; Pearson R:−0.075
1.0
Tomlins Prostate : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
−1.5 −1.0 −0.5
0.0
0.5
1.0
2
0.0
0.5
1.0
1.5
●
● ●
●
● ●
−1.5 −1.0 −0.5
0.0
0.5
1.0
1
● ●
0
●
● ●
●
●
● ●
−1
● ●
●
●
−2
●
ARHGEF11
1.0 0.5
●
2
Tomlins Prostate : Normal−Prostate Gland
1.5
Tomlins Prostate : Normal−Prostate Gland
●
0.0
−1.5 −1.0 −0.5
BCL6
●
−1.0
●
BCL6
●
ARHGEF1
1
1.5
P−value:0.37; Pearson R:0.27
−1.0
●
● ●
−1.5 −1.0 −0.5
ZBTB7A
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
P−value:0.18; Pearson R:−0.44
●
●
●●
●
1.0
P−value:0.25; Pearson R:−0.38
● ●
● ●
0
● ●
●
−1
●
●
−2
0.5
●
0.0
ARHGEF1
●
ARHGEF11
1.0
●
P−value:0.6; Pearson R:0.17
Tomlins Prostate : Normal−Prostate Gland
1.5
Tomlins Prostate : Normal−Prostate Gland
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.5 −0.5 −1.0 1.0
1.2
1.4
0.6
0.8
1.0
BCL6
BCL6
no data
no data
1.2
1.4
1.2
1.4
0.5 0.0 −0.5 −1.0
−1.0
−0.5
0.0
DLG1
0.5
1.0
0.8
1.0
0.6
ARHGEF12
0.0
DLG1
0.5 0.0 −0.5 −1.0
ARHGEF12
1.0
no data
1.0
no data
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
0.0
0.5
●
−0.5
DLG3
0.0
●
●
●
−1.0
−1.0
−0.5
DLG2
● ● ●
●
0.8
1.0
1.2
1.4
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.5
BCL6
BCL6
no data
Tomlins Prostate : Normal−Prostate Gland
1.0
0.5
0.6
●
0.0
● ●
●
−0.5
DLG3
0.0
●
●
−1.0
−0.5 −1.0
DLG2
0.5
●
●
●
0.6
0.8
1.0
1.2
1.4
−1.5 −1.0 −0.5
ZBTB7A
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
P−value:0.19; Pearson R:0.48
●
1.0
P−value:0.14; Pearson R:0.53
1.0
0.5
Tomlins Prostate : Normal−Prostate Gland
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
DLG4
●
−0.5
0.0
●
−1.5 −1.0 −0.5
0.0
0.5
1.0
0.5
●
●●
● ● ● ●
1.5
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.5
Tomlins Prostate : Normal−Prostate Gland
●
DLG4
●
●
−0.5
0.0
●
−1.5 −1.0 −0.5
0.0
0.5
1.0
●
−0.5
0.5
●
●
●
●
●
● ●
−1.5
●
●
FYN
● ●
0.5
Tomlins Prostate : Normal−Prostate Gland
P−value:0.35; Pearson R:−0.36
BCL6
1.0
BCL6
●
−1.5 −1.0 −0.5
ZBTB7A
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.0091; Pearson R:0.84
● ●
−0.5
0.5
●
−1.5
●
●
FYN
● ●
P−value:0.21; Pearson R:0.54
Tomlins Prostate : Normal−Prostate Gland
P−value:0.42; Pearson R:−0.31
1.0
Tomlins Prostate : Normal−Prostate Gland
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
0 −1 −1.5 −1.0 −0.5
0.0
0.5
1.0
1.0 0.6
0.8
1.0
●
●
−2
●
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.2
1.4
0.5 0.0
●
−0.5
0
● ● ●
1.4
−1.0
● ●
LLGL2
● ●
1.2
1.0
no data P−value:0.08; Pearson R:0.5
Tomlins Prostate : Normal−Prostate Gland
1
BCL6
●
−1
0.5
1.5
BCL6
●
LLGL1
0.0
●
●
−0.5
●
●
−2
LLGL1
●
−1.0
● ● ● ●
LLGL2
●● ●
P−value:0.49; Pearson R:0.22
1
Tomlins Prostate : Normal−Prostate Gland
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.5 1.0
●
0.5
●
●
● ● ●
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.5
Tomlins Prostate : Normal−Prostate Gland
Tomlins Prostate : Normal−Prostate Gland
−0.5
●
● ● ●
●
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.0 0.5
●
●
● ● ●
0.0
0.0
●
●
● ● ●
●
−0.5
● ●
MAP2K7
0.5
●
1.5
BCL6
1.0
BCL6
●
−1.5
●
1.5
●
MAP2K4
P−value:0.59; Pearson R:0.21
−1.5
● ●
●
●
●
−1.5 −1.0 −0.5
ZBTB7A
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
1.0
P−value:0.98; Pearson R:−0.011
●
●
0.0
●
●
P−value:0.38; Pearson R:0.27
0.0
●
●
−0.5
● ●
MAP2K7
●
●
−0.5
MAP2K4
0.5
●
P−value:0.14; Pearson R:−0.45
Tomlins Prostate : Normal−Prostate Gland
1.0
Tomlins Prostate : Normal−Prostate Gland
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
−0.5
●
●
−1.5 −1.0 −0.5
0.0
0.5
●
1.0
1.0 0.6
0.8
1.0
Tomlins Prostate : Normal−Prostate Gland
no data
●
−1.5
●
● ●
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.2
1.4
0.5 0.0
●
−0.5
●●
1.4
−1.0
●
● ●
MAPK8
1.5 0.5
●
1.2
1.0
BCL6
P−value:0.35; Pearson R:0.28
BCL6
●
−0.5
0.5
1.5
●
MAPK10
0.0
●
●
−0.5
0.5
●
−1.0
● ●●
●
−1.5
MAPK10
●
MAPK8
1.5
●
P−value:0.19; Pearson R:−0.41
Tomlins Prostate : Normal−Prostate Gland
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
−1.5
●
−1.5 −1.0 −0.5
0.0
0.5
1.0 0.5 0.6
0.8
1.0
no data
● ●
−1.5
●
−1.5 −1.0 −0.5
0.0
0.5
1.0
1.2
1.4
0.5 0.0
●
−0.5
● ●
●
1.4
−1.0
●
SCRIB
● ●
1.2
1.0
Tomlins Prostate : Normal−Prostate Gland
P−value:0.98; Pearson R:0.0074
BCL6
0.5 −0.5 0.0
1.5
BCL6
●
MAPK9
1.0
0.0
● ●
−0.5
●
−1.0
●
●
SCRIB
●
−0.5 0.0
MAPK9
●
●
●
P−value:0.71; Pearson R:0.13
0.5
Tomlins Prostate : Normal−Prostate Gland
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
●
●
−1.0
−0.5
●
0.8
1.0
1.2
1.4
−1.5 −1.0 −0.5
0.0
0.5
1.5
BCL6
no data
Tomlins Prostate : Normal−Prostate Gland
0.5
● ●
0.6
0.8
1.0
1.2
1.4
●
0.0
●
●
−0.5
−0.5
0.0
YES1
0.5
1.0
●
−1.0
SRC
1.0
BCL6
1.0
0.6
●
●
−1.5 −1.0 −0.5
ZBTB7A
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
P−value:0.13; Pearson R:−0.62
0.5
● ●
0.0
YES1
0.0 −0.5
SRC
0.5
1.0
●
1.0
P−value:0.79; Pearson R:−0.13
1.0
Tomlins Prostate : Normal−Prostate Gland
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
●
−1.0
● ●
●
●
●
−2
−1
0
1
●
● ● ●
●
● ● ●
●
●
●
●
● ● ●
−2
−1
0
1
2
Tomlins Prostate : Prostate Carcinoma
Tomlins Prostate : Prostate Carcinoma
−2.0
−1.0
●
−1.0
−0.5
0.0
0.5
●
−0.5
1.0 0.0
● ●
●
● ●
●
●
● ●
−1.5
● ●
●
0.5 1.0 1.5
BCL6
ARHGEF11
BCL6
●
ARHGEF1
●
●
2
●
P−value:0.014; Pearson R:0.57
●
P−value:0.067; Pearson R:−0.67
0.0
●
−2.0
ARHGEF1
●
●
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
P−value:0.86; Pearson R:0.073
● ●
●
0.5 1.0 1.5
●
●
−0.5
● ●
●
−1.5
1.0
●
ARHGEF11
Tomlins Prostate : Prostate Carcinoma
P−value:0.19; Pearson R:0.29
Tomlins Prostate : Prostate Carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
● ● ●
−1.0
●
●
●
0
1
0.5
●
●
●
●
●
2
●
●
−2
−1
0
BCL6
BCL6
no data
no data
1
2
1.2
1.4
0.5 −1.0
−0.5
0.0
DLG1
0.5 0.0 −0.5 −1.0
ARHGEF12
●
1.0
−1
● ● ●
●
1.0
−2
P−value:0.77; Pearson R:0.086
●
●
0.0
● ●
●
−0.5
●
DLG1
● ●
1.0
Tomlins Prostate : Prostate Carcinoma
P−value:0.71; Pearson R:−0.1
0.0 0.5 1.0 1.5
ARHGEF12
Tomlins Prostate : Prostate Carcinoma
0.6
0.8
1.0
1.2
1.4
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
P−value:0.71; Pearson R:−0.19
● ●
−1.0
−1.0
0.8
1.0
1.2
1.4
−2
0
1
2
BCL6
BCL6
no data
Tomlins Prostate : Prostate Carcinoma
0.5
●
●
0.0
0.0
DLG3
0.5
1.0
1.0
●
●
−1.0
−0.5 −1.0
DLG2
−1
1.5
0.6
●
0.6
0.8
1.0
1.2
1.4
●
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
P−value:0.46; Pearson R:−0.43
0.5
●
0.0
DLG3
0.5 0.0
●
−0.5
DLG2
●
1.0
1.0
1.5
Tomlins Prostate : Prostate Carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−3
●
−2
−1
0
1
1.0
● ●
●
● ●
●
●
●
● ● ● ●
●
●
●
−2
−1
0
1
2
BCL6
Tomlins Prostate : Prostate Carcinoma
Tomlins Prostate : Prostate Carcinoma
●
−3
−2
●
−1.0
−0.5
0.0
0.5
1.0 0.5
● ● ●
0.0
−1
●
● ● ●
−1.0
0
●
●
FYN
●
P−value:0.91; Pearson R:−0.061
BCL6
●
DLG4
●
●
2
P−value:0.98; Pearson R:0.0097
−1
●
−2
DLG4
● ●
●
0.5
●
0.0
● ●
−1.0
●●
FYN
P−value:0.1; Pearson R:0.52
●
●
0
Tomlins Prostate : Prostate Carcinoma
P−value:0.9; Pearson R:−0.032
Tomlins Prostate : Prostate Carcinoma
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ●
−1.0
●
● ●
−2
−1
0
1
1.0 0.5
●
●
●
●
●
2
−2
−1
0
● ● ●
−1.0
−0.5
0.0
0.5
1.2
1.4
0.5 0.0 −0.5
0.0
●
2
−1.0
●
LLGL2
0.5
●
● ●
1
1.0
no data P−value:0.95; Pearson R:0.027
Tomlins Prostate : Prostate Carcinoma
1.0
BCL6
●
●
●
BCL6
−1.0
LLGL1
0.0
● ●
−1.0
● ●
LLGL2
1.0 0.5
● ●
●
0.0
LLGL1
●
P−value:0.22; Pearson R:0.53
Tomlins Prostate : Prostate Carcinoma
P−value:0.39; Pearson R:0.23
Tomlins Prostate : Prostate Carcinoma
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ● ● ●●
●
●
●
●
−2
●
−2
−1
0
1
0.5
● ●
●
●
● ●
● ● ●
−2
−1
0
1
2
Tomlins Prostate : Prostate Carcinoma
Tomlins Prostate : Prostate Carcinoma
●
−2
●
−1.0
−0.5
0.0
0.5
−0.5
● ● ●
● ●
●
● ●
●
●
−1.5
0
●
MAP2K7
1
●
0.5
BCL6
2
BCL6
● ●
−1
● ●
2
P−value:0.69; Pearson R:0.16
−1
●
●
●
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
P−value:0.87; Pearson R:−0.076
● ●
● ●●
●
−0.5
● ●●
−1.5
●
MAP2K7
P−value:0.3; Pearson R:0.24
●
0
MAP2K4
1
●
●
MAP2K4
P−value:0.89; Pearson R:−0.035
Tomlins Prostate : Prostate Carcinoma
2
Tomlins Prostate : Prostate Carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●●
●
● ●
● ● ●
−2
●
●
● ●
−2
−1
●
0
1
1
● ●
0
● ●
●
●
● ●
2
●
●
●
−2
−1
0
1
2
Tomlins Prostate : Prostate Carcinoma
●
−2
●
● ●
−1.0
−0.5
0.0
●
0.5
1 0
●
●
−1
●
●
−2
−1
0
●
● ●
MAPK8
1 ●
P−value:0.74; Pearson R:−0.2
Tomlins Prostate : Prostate Carcinoma
P−value:0.0034; Pearson R:−0.85
BCL6
2
BCL6
●
MAPK10
●
●
−1
0
●
●
● ●
−2
●
●
−1
MAPK10
1
●
●
MAPK8
2
●
P−value:0.022; Pearson R:0.57
Tomlins Prostate : Prostate Carcinoma
P−value:0.99; Pearson R:0.0021
Tomlins Prostate : Prostate Carcinoma
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
●
●
●
−2.0
● ●
−2
−1
0
1
0.6
0.8
1.0 BCL6
Tomlins Prostate : Prostate Carcinoma
no data
−1.0 −2.0
●
−1.0
−0.5
0.0
0.5
1.2
1.4
0.5 0.0
●
−0.5
●
●
1.4
−1.0
P−value:0.23; Pearson R:0.53
1.0
●
1.2
1.0
BCL6
●
0.0
0.5
2
●
MAPK9
0.0
● ●
●
SCRIB
0.0
● ●
●
−1.0
MAPK9
● ●
−0.5
●
−1.0
●
●
SCRIB
P−value:0.54; Pearson R:0.15
1.0
● ●
1.0
Tomlins Prostate : Prostate Carcinoma
0.6
ZBTB7A
0.8
1.0 ZBTB7A
Biology Open | Supplementary Material
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
no data
P−value:0.78; Pearson R:0.089
1.0
Tomlins Prostate : Prostate Carcinoma
0.0
●
●
● ● ●
0.8
1.0
1.2
1.4
−2
●
−1
0
1
2
BCL6
BCL6
no data
Tomlins Prostate : Prostate Carcinoma
0.5 0.0
● ●
−0.5
YES1
0.5 0.0
●
●
−1.0
−0.5 −1.0
SRC
P−value:0.61; Pearson R:−0.31
1.0
0.6
● ●
−1.0
−1.0
●
●●
−0.5
YES1
0.0 −0.5
SRC
0.5
0.5
●
0.6
0.8
1.0
1.2
1.4
●
−1.0
ZBTB7A
−0.5
0.0
ZBTB7A
Biology Open | Supplementary Material
0.5
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ●
0.7
●
●
0.4
0.6
0.8
1.0
1.2
−0.10
● ●
● ● ●
● ●
●
●
●
0.4
0.6
0.8
1.0
1.2
1.4
Toruner Head−Neck : all−oral squamous carcinoma
Toruner Head−Neck : all−oral squamous carcinoma
●● ●
0.9
●
● ● ●
●
−0.85
−0.75
−0.65
●
−0.10
●
●
−0.20
1.1
●
●
● ● ● ●
−0.30
●
●
●
● ● ● ●
●
−0.40
● ●
ARHGEF11
1.3
●
●
●
−0.85
ZBTB7A
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
P−value:0.065; Pearson R:0.47
BCL6
P−value:0.15; Pearson R:0.37
BCL6
●
0.7
●
1.4
●
ARHGEF1
●
●
P−value:0.48; Pearson R:0.19
1.1
●
0.9
ARHGEF1
●● ●
●
●
−0.20
● ●
−0.30
●●
●
−0.40
1.3
●
Toruner Head−Neck : all−oral squamous carcinoma
ARHGEF11
● ●
P−value:0.78; Pearson R:0.075
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
● ●
0.4
0.6
0.8
1.0
1.2
−1.45
●
● ● ● ●
0.4
0.6
0.8
1.0
1.2
1.4
Toruner Head−Neck : all−oral squamous carcinoma
●
●
●
●
●
●
● ●
−0.85
−0.75
−0.65
−1.45 −1.55
● ●
●
●
−1.65
●
−1.75
●
DLG1
0.6 0.4
● ●
●
●
●
●
●
●
● ● ●
●
● ● ● ●
−0.85
ZBTB7A
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
P−value:0.13; Pearson R:0.39
Toruner Head−Neck : all−oral squamous carcinoma
P−value:0.017; Pearson R:0.59
BCL6
0.0
0.2
●
BCL6
●
−0.2
●
● ● ●
1.4
●
ARHGEF12
●
●
● ●
P−value:0.92; Pearson R:0.026
●
−1.55
● ●
0.0
0.2
● ●
●
−1.65
●
●
−1.75
● ●
●
Toruner Head−Neck : all−oral squamous carcinoma
DLG1
0.4
●
−0.2
ARHGEF12
0.6
●
P−value:0.63; Pearson R:−0.13
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ● ●
●
● ●
●
−1.3
●
●
●
0.4
0.6
0.8
1.0
1.2
0.5 0.4
●
0.3
● ● ● ●
● ● ●
●
●
●
1.4
0.4
0.6
0.8
1.0
1.2
1.4
●
−1.2
● ● ●
●
●
● ●
−1.3
●
●
●
−0.85
−0.75
−0.65
0.4
● ● ● ● ●
0.3
● ● ●
0.2
●
●
●
● ●
●
0.1
−1.0 −1.1
● ●
DLG3
●
●
●
−0.85
ZBTB7A
●
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
P−value:0.57; Pearson R:0.15
Toruner Head−Neck : all−oral squamous carcinoma
0.5
Toruner Head−Neck : all−oral squamous carcinoma
P−value:0.78; Pearson R:−0.076
BCL6
−0.9
BCL6
●
DLG2
● ●
P−value:0.54; Pearson R:0.16
●
●
0.2
●
●
●
0.1
−1.0 −1.1
●
−1.2
DLG2
●
Toruner Head−Neck : all−oral squamous carcinoma
DLG3
● ●
P−value:0.089; Pearson R:0.44
−0.9
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
−0.2
● ●●
●
● ●
●
●
0.4
0.6
0.8
1.0
1.2
1.5
● ● ●
●
●
●
●
●
0.4
0.6
0.8
1.0
1.2
1.4
●
●
● ●
● ●
●
●
−0.85
−0.75
−0.65
●
1.0
●
●
0.5
●
● ● ● ●
0.0
0.0
●
FYN
● ●
● ●
● ●
●
● ● ●
● ●
−0.85
ZBTB7A
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
P−value:0.98; Pearson R:0.0062
Toruner Head−Neck : all−oral squamous carcinoma
1.5
Toruner Head−Neck : all−oral squamous carcinoma
P−value:0.057; Pearson R:0.48
BCL6
●
−0.2
● ●
● ●
1.4
●
−0.4
● ●
BCL6
●
DLG4
●
P−value:0.63; Pearson R:0.13
●
−0.4
DLG4
●
1.0
0.0
●
●
0.5
●
0.0
●
Toruner Head−Neck : all−oral squamous carcinoma
FYN
●
P−value:0.83; Pearson R:−0.059
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
Toruner Head−Neck : all−oral squamous carcinoma
●
● ●
●
● ● ●
0.4
●
0.6
0.8
1.0
1.2
−0.6 −0.8 ●
●
●
● ● ●
● ● ●
●
1.4
0.4
0.6
●
0.8
1.0
1.2
1.4
BCL6
Toruner Head−Neck : all−oral squamous carcinoma
Toruner Head−Neck : all−oral squamous carcinoma
● ●
●
●
0.6
● ●
●
0.4
●
●
−0.85
−0.75
−0.65
−0.6
●
−0.8
●
●
−1.0
● ●
●
● ●
●
●
●
−1.2
● ●
LLGL2
1.2 1.0
●
●
● ● ●
●
−0.85
ZBTB7A
●
●
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
●
P−value:0.52; Pearson R:−0.17
BCL6
●
0.8
●
●
0.4
LLGL1
−1.0
●
P−value:0.52; Pearson R:0.17
0.8
● ●
● ●
●
−1.2
●
LLGL2
●
●
0.6
LLGL1
1.0
●
P−value:0.3; Pearson R:0.27
1.2
●
P−value:0.79; Pearson R:−0.072
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ●
●
0.4
0.6
0.8
1.0
1.2
−0.6
●
●
● ● ●
● ●
●
●
1.4
0.4
0.6
0.8
1.0
1.2
1.4
Toruner Head−Neck : all−oral squamous carcinoma
●
●
0.5
● ●
●
●
●
● ●
●
−0.85
−0.75
−0.65
−0.6
● ●
●
●
−0.8
●
● ●
●
●
●
● ● ●
−1.0
●
●
MAP2K7
1.0
● ●
●
−0.85
ZBTB7A
● ●
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
P−value:0.22; Pearson R:0.33
Toruner Head−Neck : all−oral squamous carcinoma
P−value:0.35; Pearson R:−0.25
BCL6
●
0.0
● ●
BCL6
●
MAP2K4
●
P−value:0.31; Pearson R:0.27
0.5
●
● ●
●
−0.8
●
●
−1.0
●
● ● ●
0.0
MAP2K4
1.0
● ●
Toruner Head−Neck : all−oral squamous carcinoma
MAP2K7
● ●
P−value:0.31; Pearson R:−0.27
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
−0.5
●
●
0.4
0.6
0.8
1.0
1.2
1.0 0.8 0.6
● ●
●
● ● ● ●
●
1.4
0.4
0.6
0.8
1.0
1.2
1.4
● ●
● ● ●
●
−0.5
●
●
−0.85
−0.75
−0.65
0.8
1.0
●
0.6
●
●
●
●
● ●
0.4
● ●
●
●
● ●
●
●
0.2
0.5
●
0.0
●
●
MAPK8
1.0
●●
●
−0.85
ZBTB7A
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
●
P−value:0.086; Pearson R:0.44
Toruner Head−Neck : all−oral squamous carcinoma
P−value:0.59; Pearson R:0.15
Toruner Head−Neck : all−oral squamous carcinoma
1.5
BCL6
●
0.0
●
BCL6
●
MAPK10
●
● ●
P−value:0.17; Pearson R:0.36
● ●
●
0.4
●
●
●
● ●
0.2
●
●
●
0.0
0.5
●
Toruner Head−Neck : all−oral squamous carcinoma
MAPK8
●
●
0.0
MAPK10
1.0
●●
P−value:0.011; Pearson R:0.62
1.5
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●●
0.5
● ●
0.3
●
●
● ●
0.4
0.6
0.8
1.0
1.2
1.0
● ● ●
● ● ●
● ● ●
1.4
0.4
0.6
0.8
1.0
1.2
1.4
BCL6
Toruner Head−Neck : all−oral squamous carcinoma
Toruner Head−Neck : all−oral squamous carcinoma
●
● ● ●
0.5
● ●
● ● ●
0.3
● ●
−0.85
●
−0.75
−0.65
1.0
● ●
0.5
●
●
● ●
●
● ● ● ● ●
0.0
0.7
●
SCRIB
0.9
●
●
●
● ● ●
−0.85
ZBTB7A
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
P−value:0.57; Pearson R:0.15
BCL6
●
MAPK9
●
●
●
●
P−value:0.63; Pearson R:−0.13
●
● ●
●
●
0.5
●
●
0.0
●
Toruner Head−Neck : all−oral squamous carcinoma
SCRIB
●
P−value:0.22; Pearson R:0.32
0.7
MAPK9
0.9
●
P−value:0.92; Pearson R:0.026
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
0.6
0.7
●
●
0.4
0.6
0.8
1.0
1.2
2.5 2.0
● ● ●
● ● ●
● ●
●●
● ●
0.4
0.6
0.8
1.0
1.2
1.4
Toruner Head−Neck : all−oral squamous carcinoma
Toruner Head−Neck : all−oral squamous carcinoma
● ●
0.8
● ●
●
0.6
0.7
●
●
−0.85
●
●
−0.75
−0.65
2.5
●
2.0
●
1.5
●● ●
●
● ● ● ●
●
●
1.0
●
YES1
1.1
● ●
● ●
●● ●
●
−0.85
ZBTB7A
−0.75 ZBTB7A
Biology Open | Supplementary Material
−0.65
●
P−value:0.51; Pearson R:−0.18
BCL6
P−value:0.28; Pearson R:0.29
BCL6
1.0 0.9
●
●
1.4
●
SRC
●
P−value:0.96; Pearson R:−0.013
0.9
● ● ●
0.8
SRC
●
●
1.5
1.0
●● ●
1.0
1.1
●
Toruner Head−Neck : all−oral squamous carcinoma
YES1
●
●
P−value:0.063; Pearson R:0.48
Toruner Head−Neck : all−oral squamous carcinoma
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
●
● ●
●
● ●
● ●
●
●
●
●
●
●
−0.4
● ●
1.0
1.5
2.0
1.5
2.0
2.5
●
●
●
●● ●
●
● ●
● ●
● ●
● ●
●
●
● ●
● ●
●
●
● ● ●
−0.4
● ●
−0.5
3.0
● ●
●
0.0
● ●
0.2
1.0
●
● ●
●
● ●
●
● ● ●● ●
●
●
−0.4
●
0.0
●
0.5
●
ARHGEF1
● ●
Zhai Cervix : all
●
−1.0
●
Zhai Cervix : all
●
●
●
● ●
3.0
●
●
●
●
●
●
● ● ●
●
BCL6
●
●
● ●
● ●
●
●● ●●
● ●
●
● ● ●
●
●
●
●
●
● ●
●
●●
●
●
●
●
● ●
−0.8
0.4
2.5
●
●
BCL6
0.6
0.5
●
●
●
0.0
ZBTB7A
●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
P−value:0.022; Pearson R:−0.37
●
●● ● ● ●
ARHGEF11
0.2
● ●
0.0
ARHGEF1
●
●
●
0.0
P−value:0.21; Pearson R:0.21
●
●
0.0
●
−0.4
●
● ●
−0.8
●
● ●
ARHGEF11
●
P−value:0.83; Pearson R:−0.037
●
●
0.4
Zhai Cervix : all
P−value:0.41; Pearson R:−0.14
0.6
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
●
●
●
● ● ●
● ●
●
●
1.0
1.5
2.0
2.5
0.0
●
●
● ●
● ●
●
●
●
● ● ●
3.0
0.5
1.0
1.5
2.0
2.5
1.5
●
●
●
●
●
●
● ●
●
● ● ● ●
●
●
●
●●
● ● ●
● ●
●
●
●
●
●
0.0
●
●
−0.5
●
3.0
● ●
●
0.0
● ●
1.0
●
●
●
● ●● ●
Zhai Cervix : all
●
0.5
●
●
●
● ●
Zhai Cervix : all
●
ARHGEF12
●
BCL6
●
−1.0
●
BCL6
●
●
●
● ●
●
● ● ●
●
●
●
● ●
● ● ●
●
●● ●
●
● ●
●
●
● ● ●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
●
●
●
●
●
ZBTB7A
●●
● ●
0.0
●
●
−0.5
0.5
●
−1.0
●
−1.5
0.5
●
● ● ●
●
0.0
P−value:0.7; Pearson R:−0.066
● ● ● ●
●
−0.5
●
●
DLG1
1.0
●
● ●
●
0.0
ARHGEF12
●
●
●
−1.0
●
●
●
●
−1.5
●
●
P−value:0.66; Pearson R:0.074
1.5
●
●
DLG1
●● ● ●
P−value:0.021; Pearson R:0.37
Zhai Cervix : all
P−value:0.98; Pearson R:0.0033
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
● ● ●
●
● ●
●
●
●
●
●
●
●
●
●
1.0
1.5
2.0
2.5
●
● ●
1.0
●
●
● ●
● ●
●
1.0
●
● ●
1.5
●
2.0
2.5
Zhai Cervix : all
Zhai Cervix : all
●
●
●
●
● ●
●
● ●
●
● ● ● ●
●
●
● ● ● ● ●
●
●
●
●
● ●
−2.0
●
●
−0.5
1.0
●
●
●
●
0.8
● ●
●
3.0
●
● ● ●
●
0.6
−0.8 −1.2
● ●
BCL6
●
−1.6
●
0.5
●
DLG2
● ● ●
BCL6
● ●
−1.0
● ●
●
●
●
3.0
●
●
●
●
●
●
● ●
●
● ● ●
0.4
0.5
●
●
●● ●
0.2
−2.0
● ●
● ●
●
DLG3
−1.6
●
●
●
●
●
0.0
ZBTB7A
●
●
●
●
● ●
● ●●
−1.0
●
● ●
−0.5 ZBTB7A
Biology Open | Supplementary Material
●
● ● ● ●
P−value:0.69; Pearson R:0.067
●
●
●
0.0
P−value:0.99; Pearson R:−0.002
● ●
● ●
0.8
●
●
0.6
●
●
0.4
●
−1.2
DLG2
●●
●
●
● ●
0.2
● ●
●
DLG3
●
P−value:0.65; Pearson R:0.077
Zhai Cervix : all
P−value:0.65; Pearson R:0.077
−0.8
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
● ●
●
●
● ●
●
● ●
●
●
●
●
●
1.0
1.5
2.0
2.5
●
1.0
● ● ● ●●
●
● ●
●
●●
●
●
●
● ● ●● ● ●
●
● ● ● ●
●
● ● ●
●
●
●
●
●
● ● ●
●
●
●
● ●
●
−0.5
●
● ●
1.0
1.5
2.0
2.5
Zhai Cervix : all
3.0
1.0
● ●
●
●
●
0.5
−1.0
●●
Zhai Cervix : all
●
−2.0
●
● ●
BCL6
●
−3.0
● ●
BCL6
●
DLG4
●
●
0.5
●
−1.0
●
3.0
●
●
●
● ●
● ● ●
●
●
●
●
● ●
0.0
0.5
● ●
●
●
●
●
●●
−1.0 −0.5
−3.0
●
●
FYN
−2.0
DLG4
● ●
● ●
●
● ●
0.0
ZBTB7A
● ●
●
●
● ●
●
●
●
●
● ●
● ●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
● ●
0.0
P−value:0.27; Pearson R:−0.19
● ●
●
● ● ● ● ● ●
0.5
●
● ● ●
0.0
●
●
●
−1.0 −0.5
●
●
FYN
● ●
P−value:0.24; Pearson R:0.19
−1.0
●
P−value:1; Pearson R:−0.00053
Zhai Cervix : all
P−value:0.36; Pearson R:−0.15
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●
● ●
●● ●
●
●●
●
●
● ●
● ● ●
−0.8
● ●
1.0
1.5
2.0
2.5
0.0
4.0
●
●
● ●
● ●
●
●
●
● ●
●
● ● ●
● ●
● ● ●
●
●
● ● ●
● ●
−0.5
●
● ●
●
● ●
●
●
●
1.0
1.5
2.0
2.5
3.0
●
4.0
●
●
−0.4
●
● ● ●
Zhai Cervix : all
●
−0.8
●
Zhai Cervix : all
●
LLGL1
●●
●
BCL6
●
−1.0
●
●
0.5
●
●
●
●
3.0
●
●
● ●
●
BCL6
●
●
●
●
●
●
●
● ●
● ●
● ● ●
●
3.5
0.4
0.5
● ●
● ● ●
● ●
●
ZBTB7A
●
●
●
●
● ●
●
●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
● ●
●
●
0.0
●
● ● ●
● ●●●
P−value:0.32; Pearson R:−0.17
●
●
● ● ●
3.0
●
● ●
●
LLGL2
0.0
● ●
−0.4
LLGL1
●
0.0
P−value:0.51; Pearson R:0.11
● ●
●
3.5
●●
●
●
●
●
3.0
● ●
●
LLGL2
●
P−value:0.54; Pearson R:−0.1
0.4
●
Zhai Cervix : all
P−value:0.035; Pearson R:−0.34
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
● ●
−0.5
●
●
● ●
● ●
●●
●
1.0
1.5
2.0
2.5
−0.8
●
●
●
●
● ●
● ●
1.0
1.5
2.0
2.5
Zhai Cervix : all
0.5
● ● ● ● ●● ● ●
●
●
●
●● ●
●
● ●
●
●
●
● ●
●
● ● ●
●
● ●
●
−0.5
●
● ●
● ●
● ●
●
● ●●
●●
● ● ● ●
● ●
●
●
● ●●
3.0
●
● ●
−0.8
1.0
●
−0.4
Zhai Cervix : all
●
0.0
●
BCL6
●
−0.5
● ●
BCL6
● ●
MAP2K4
●
●
0.5
●
−1.0
●
●
●● ●
●
●
3.0
●
●
●
● ● ● ● ●
−1.2
0.5
●
●
●
●
● ●
●
●
● ●
−1.6
●
● ● ●
● ●
●
●
0.0
ZBTB7A
● ●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
P−value:0.75; Pearson R:0.054
●
●●● ●
● ●
0.0
P−value:0.14; Pearson R:0.24
●
● ●
● ●
−1.2
●
●
●
MAP2K7
0.5
●
●
0.0
MAP2K4
●
● ● ●
−1.6
●
MAP2K7
●
●
P−value:0.032; Pearson R:0.35
1.0
● ●
−0.4
Zhai Cervix : all
P−value:0.51; Pearson R:−0.11
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
● ●
● ●
●
0.0
●
● ●
● ● ●
●
●
●
● ●
0.5
1.0
1.5
●
2.0
2.5
1.5
●
● ●
●
●
1.0
● ●
●
●
0.5
●
●
● ●
● ●
−0.5
● ●
● ●
1.0
1.5
2.0
2.5
Zhai Cervix : all
● ●
● ●
● ●
● ●
● ● ●●
●
0.0
MAPK10
●
●
●
Zhai Cervix : all
●
●
● ●
●
● ●
−1.0
●
● ● ●
●
−0.5
●
●
●
●
BCL6
●
●
●
●
BCL6
●
●
● ●
●
0.5
●
●
●
3.0
●
●
● ●
3.0
●
● ●
●
●
● ●
●
● ●
●● ●
●
●
● ●
● ●
●
● ● ●
0.0
ZBTB7A
●
● ●
● ● ● ●
● ●
●
●
●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
●
●
●
P−value:0.48; Pearson R:−0.12
● ●
●
● ●
●
0.0
P−value:0.71; Pearson R:−0.063
●
● ●
●
●
0.0
1.0
●
0.5
MAPK10
●
−1.0
●
●
−0.5
●
−1.0
●
−1.5
●
●
MAPK8
●
● ●
−1.5
●
P−value:0.11; Pearson R:0.27
1.5
●
MAPK8
●
0.0
Zhai Cervix : all
P−value:0.18; Pearson R:−0.22
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●●
●
●
●
●
●
●
−1.0
● ● ●
1.0
1.5
2.0
2.5
●
● ● ●
●●
●
●
1.0
1.5
2.0
2.5
●
●
●
● ●
● ●● ●
●
●
● ● ●
● ●
●
●
● ●
−0.5
●
● ● ● ●
−0.5
4.0
3.0
●
● ●
3.5
● ●
●
●
● ●
●
●
●
● ●
3.0
● ●
●
●
●
● ●
●
●
●
● ●
● ●
●
● ●
●
0.0
ZBTB7A
●
●
● ●
●
●
● ●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
●
●
●
2.5
0.5
● ●
●
●
Zhai Cervix : all
●
0.0
● ●
Zhai Cervix : all
●
−1.0
● ●
●●
BCL6
●
MAPK9
● ●
0.5
●
−1.0
●
●
3.0
●
●
●
●
● ● ●
BCL6
●
●
●
2.0
0.5
●
●
●
SCRIB
●
● ●
P−value:0.73; Pearson R:0.059
●
P−value:0.12; Pearson R:−0.26
0.0
●
●
● ●
●
●
−0.5
MAPK9
●
● ●
0.0
P−value:0.034; Pearson R:0.34
● ●
●
●
● ●
●
●
3.5
●
●
3.0
●
2.5
0.5
● ●
●
2.0
● ●
SCRIB
● ●
4.0
Zhai Cervix : all
P−value:0.44; Pearson R:0.13
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●● ●
●
●
●
●● ●
● ●
●
●
●
● ●
● ● ●
1.0
1.5
2.0
2.5
● ●
●
●
1.0
1.5
2.0
2.5
●
● ●
●
●
●
●
●
● ● ●
●
●●
●
●
●●
● ●
●
−2.5
●
● ● ●
−0.5
3.0
4
●
3
● ● ●
●
●
●
●
● ● ●● ●
2
●
●
−1.5
●
●
0.5
●
SRC
●
Zhai Cervix : all
●
−1.0
●
●
●● ● ●
Zhai Cervix : all
●
●
● ●● ● ● ● ●
●
●
BCL6
●
●
● ●
●
3.0
●
●
● ● ●
●
●
●
BCL6
−0.5
0.5
● ●
●
●
●
● ●● ● ●
●
● ●
0.0
ZBTB7A
● ●
●
● ●
●
●
1
−2.5
●
YES1
−1.5
SRC
● ●
●
●
●
● ● ●
●
● ● ●
−1.0
−0.5 ZBTB7A
Biology Open | Supplementary Material
● ●
●
P−value:0.047; Pearson R:0.32
●
●
0.0
P−value:0.92; Pearson R:−0.018
● ● ● ● ● ●
4
●
3
● ●
●
●
2
●
1
●
YES1
●
P−value:0.35; Pearson R:−0.16
Zhai Cervix : all
P−value:0.67; Pearson R:0.071
−0.5
Zhai Cervix : all
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
●
●
● ●
● ● ●
●
●
−0.4
● ●
1.0
1.5
2.0
●
●
●
●
●
● ● ● ●
●
1.0
1.5
2.0
2.5
3.0
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
●
● ●●
● ●
●
●
0.0
● ● ●
● ● ●
●
● ● ●
●
−0.4
● ●
−1.0
−0.6
−0.2
0.0 0.2
● ●
● ●
● ● ●
●
● ●
−0.4
●
●
● ●
● ●
●
●
●
●
●●
●
●
● ● ●
−0.8
●
ARHGEF11
●
●
●
0.2
●
●
●
3.0
●
ARHGEF1
●
BCL6
●
−1.4
● ●
●
BCL6
0.6 0.4
2.5
●
● ●
●
●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
P−value:0.099; Pearson R:−0.32
●● ●
● ●
●
●
−0.2
P−value:0.27; Pearson R:0.22
0.2
●
0.0
ARHGEF1
●
●
0.0 0.2
●
●
●
−0.4
●
● ●
−0.8
●
●
ARHGEF11
●
●
P−value:0.51; Pearson R:−0.13
Zhai Cervix : Cervical squamous
P−value:0.34; Pearson R:−0.19
0.4
0.6
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
● ●
●
●
1.0
1.5
2.0
0.0
● ●
●
● ●
●
●
● ● ●
1.0
1.5
2.0
2.5
3.0
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
● ● ● ● ● ●●
●
●
●
●
●
0.0
●
● ● ●
●
●
●
●
−1.0
−0.6
−0.2
0.0
●
● ●
●
●
−0.5
●
●
●
−1.0
1.5
●
● ●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
● ●
−1.5
●
DLG1
●
1.0
● ● ●
BCL6
●
0.5
●
●
●
●
3.0
●
−1.4
●
BCL6
●
ARHGEF12
2.5
●
●
●
● ●
●
● ● ●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.2
P−value:0.66; Pearson R:−0.086
0.5
●
●
●
●
●
−0.5
● ● ● ●
●
●
−1.0
● ●
● ●
●
●
−1.5
●
P−value:0.51; Pearson R:0.13
1.5 1.0
●
●
0.0
ARHGEF12
●
●
DLG1
●● ● ●
P−value:0.006; Pearson R:0.51
Zhai Cervix : Cervical squamous
P−value:0.91; Pearson R:0.022
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
● ●
● ●
●
●
●
●
−1.8
● ● ●
●
1.0
1.5
2.0
1.0
●
●
● ●
●
●
● ●
●
● ●
● ●
●
1.0
1.5
●
2.0
2.5
3.0
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
●
● ● ●
● ●
● ●
●
●
●
●
−1.8
● ●
●
●
−1.0
−0.6
−0.2
1.0 0.8
●
●
●
●
● ● ●
0.6
● ●
●
● ● ●
●
● ●
0.4
●
●
●● ●
●
● ● ●
0.2
● ●
●
DLG3
−1.0
●
●
P−value:0.5; Pearson R:−0.13
BCL6
●
−1.4
● ●
●
●
3.0
●
−1.4
●
BCL6
●
DLG2
2.5
● ●
●
● ● ●●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
●
P−value:0.58; Pearson R:0.11
●
●
●
−0.2
P−value:0.75; Pearson R:−0.063
● ●
●
●
0.8
●
●
●
● ●
0.6
● ● ●
−1.4
●
0.4
●
●
0.2
●
DLG3
−1.0
●
●
DLG2
Zhai Cervix : Cervical squamous
P−value:0.049; Pearson R:0.38
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
●
−2.5
●
● ●
●
●
−3.0
●
●
●
1.5
2.0
2.5
1.0
●
●
● ● ● ●●
●
●
● ●
● ●
1.5
2.0
2.5
3.0
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
●
● ● ●● ● ●
● ● ● ●
● ● ●
● ●
●
●
●
●
●
−3.0
●
●
●
−1.0
−0.6
−0.2
1.0
● ●
●
●
●
0.5
−1.5
●
BCL6
●
−2.0
● ●
BCL6
●
−2.5
●
1.0
●
DLG4
●
● ●
3.0
●
−1.4
●
● ●
●
●
● ● ●
0.0
−1.0
1.0
● ●
● ● ●
●
●
● ●
● ● ● ●
● ● ●
● ●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
P−value:0.69; Pearson R:−0.079
●
−0.2
P−value:0.64; Pearson R:−0.093
−2.0
●
DLG4
●●
● ● ● ●
0.5
●
0.0
●
−1.0 −0.5
●
●
● ● ●
−1.0 −0.5
●
●
FYN
−1.5
●
FYN
●
P−value:0.12; Pearson R:−0.3
Zhai Cervix : Cervical squamous
P−value:0.92; Pearson R:−0.019
−1.0
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
●●
●
●
●
● ● ●
●●
●
●
● ● ●
−0.8
● ●
1.5
2.0
2.5
●
●
●
●
● ●
● ●
● ●
●
●
●
4.0
● ●
●
●
●
1.0
1.5
2.0
2.5
3.0
BCL6
BCL6
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
●
0.0
● ● ● ●
● ●
●
●
●
●
●
● ●
−0.4
●
● ●
● ●
● ● ●
−0.8
● ●
−1.0
−0.6
−0.2
4.0
●
●
●
● ●
● ● ●
●
● ●
● ●
3.5
●
●
●
●
● ●●
●
●
●
●
●
3.0
● ●
LLGL1
● ●
3.0
●
−1.4
● ● ●
LLGL2
0.4
1.0
P−value:0.13; Pearson R:−0.29
0.0
●
−0.4
LLGL1
●
●
●
●
●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.2
●
P−value:0.84; Pearson R:0.041
● ●
●
●
●
3.5
●
3.0
● ●
●
LLGL2
●
P−value:0.2; Pearson R:−0.25
Zhai Cervix : Cervical squamous
P−value:0.17; Pearson R:−0.26
0.4
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
● ●
●●
●
1.0
1.5
2.0
2.5
●
● ●
● ● ● ● ●
● ●
●
●
●
●
●
● ●
●
1.5
2.0
2.5
3.0
BCL6
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
●
●
●
● ●
0.0
●
● ●
●
●
●
−0.4
●
● ● ●
●
−1.0
−0.6
−0.2
●
● ●
−0.8
●
● ● ● ● ●
●
● ● ● ●
●
●●
●
●
● ●●
−1.2
●
●
● ● ●
● ●
● ●
● ● ●
−1.6
0.4
●
−0.4
BCL6
●●
0.2
●
1.0
●
MAP2K4
●
3.0
●
−1.4
●
●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
P−value:0.64; Pearson R:−0.092
0.0
●
●
●
−0.2
P−value:0.013; Pearson R:0.46
●
−0.8
● ●
●
−1.2
●
●
●
●
MAP2K7
0.2
● ●● ●
●
●
●
−0.4
MAP2K4
●
● ●
−1.6
●
●
P−value:0.9; Pearson R:0.024
0.4
●
MAP2K7
●
−0.4
Zhai Cervix : Cervical squamous
P−value:0.83; Pearson R:0.042
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
● ●
● ● ● ●
●
● ●
●
0.0
●
●
●
●
●
●
1.0
1.5
2.0
2.5
●
−0.5
● ● ● ●
●
●
●
●
● ● ●
● ●
● ●
1.0
1.5
2.0
2.5
3.0
●
● ●
● ●
● ● ● ●
●
●
●
● ●
●
0.0
●
●
●
−1.0
−0.6
●
−0.2
●
●
−1.0
●
●
●
●
●
●● ●
●
● ●
● ●
●
● ● ●
●
● ●
● ●
−1.5
1.0
●
MAPK8
●
−0.5
Zhai Cervix : Cervical squamous
P−value:0.93; Pearson R:0.017
Zhai Cervix : Cervical squamous
1.5
BCL6
●
−1.4
●
●
●
3.0
●
●
●
●
●
●
BCL6
●
0.5
●
● ●
● ● ●
● ●
● ●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
P−value:0.58; Pearson R:−0.11
●
●
●
−0.2
P−value:0.12; Pearson R:−0.3
●
●
−1.0
●
●
−1.5
●
0.5
MAPK10
1.0
●
MAPK8
● ●
●
MAPK10
Zhai Cervix : Cervical squamous
P−value:0.19; Pearson R:−0.25
1.5
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
● ●
●
●
●
● ● ●
●
●
−0.5
●
●
1.0
1.5
2.0
2.5
●
●
●
●
●
●● ●
●
● ●
●
● ● ●
●●
●
●
1.0
1.5
2.0
2.5
3.0
●
● ●
● ●
●
●
●
●
●
● ●
● ●
−0.5
●
●
−1.0
−0.6
−0.2
3.5
●
●
●
3.0
● ●
●
●
●
● ●
●
● ●
●
● ● ●
●
2.5
0.5
●
●
●
●
●
● ●
●
● ●
● ●
2.0
●
SCRIB
●
4.0
Zhai Cervix : Cervical squamous
P−value:0.67; Pearson R:−0.084
Zhai Cervix : Cervical squamous
●
0.0
●
●
BCL6
●
MAPK9
● ●
3.0
●
−1.4
●
BCL6
●
●
●
●
● ●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
P−value:0.11; Pearson R:0.31
● ●
●
−0.2
P−value:0.19; Pearson R:0.26
●
0.0
MAPK9
●
● ● ●
3.5
●
● ●
●
3.0
0.5
● ●
2.5
●
●
2.0
●
SCRIB
● ●
4.0
Zhai Cervix : Cervical squamous
P−value:0.81; Pearson R:0.047
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
●
●
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●
●
●
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●
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1.0
1.5
2.0
2.5
4
●
●
●
●
●●
●
●
●
●
● ●
● ● ●
●
1.5
2.0
2.5
3.0
BCL6
BCL6
Zhai Cervix : Cervical squamous
Zhai Cervix : Cervical squamous
● ● ●
●
●●
● ●
●●
●
● ●
● ●
●
●
−1.0
−0.6
−0.2
4 3
●
● ●
● ● ●● ●
2
● ● ●
●
●
●
●
●
● ●● ● ●
●
● ●
● ●
●
1
●
YES1
−2.5 −2.0 −1.5 −1.0
SRC
●
●
1.0
●
−1.4
● ● ●●
●
●
●
3.0
●
●
● ●
●
●
●
●
● ● ●
●
−1.4
ZBTB7A
−1.0
−0.6 ZBTB7A
Biology Open | Supplementary Material
−0.2
P−value:0.99; Pearson R:−0.0028
●
● ● ●●
3
●
2
●
1
● ● ● ●
●
●
YES1
●
●
P−value:0.77; Pearson R:0.058
−2.5 −2.0 −1.5 −1.0
SRC
●
P−value:0.072; Pearson R:0.34
Zhai Cervix : Cervical squamous
P−value:0.29; Pearson R:−0.21
Zhai Cervix : Cervical squamous
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−0.2
●
● ●
0.5
1.0
1.5
2.5
0.2 0.0
● ●
3.0
0.5
1.0
1.5
2.0
2.5
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
●
●
● ●
● ●
−0.6
−0.4
−0.2
0.0
0.2 0.0 −0.2
0.0
●
● ●
●
●
●
●
●
−0.4
●
3.0
●
ARHGEF11
0.2
●
P−value:0.48; Pearson R:0.25
BCL6
0.4
BCL6
●
−0.2
ARHGEF1
2.0
●
● ●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.22; Pearson R:−0.43
●
P−value:0.78; Pearson R:−0.1
●
●
●● ●
●
−0.2
●
● ●
−0.4
●
●
ARHGEF11
0.2
●
P−value:0.63; Pearson R:0.17
Zhai Cervix : Normal−Cervix squamos
●
0.0
ARHGEF1
0.4
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
0.5
1.0
1.5
2.0
2.5
−0.7 −0.9
● ●
0.5
1.0
1.5
2.0
2.5
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
●
●
0.4
●
●
−0.6
−0.4
−0.2
0.0
−0.7
●
−0.9
0.8
●
●
● ● ● ●
−1.1
● ●
3.0
● ●
DLG1
●
−0.5
BCL6
1.2 1.0
●
BCL6
●
0.6
●
3.0
●
ARHGEF12
●
● ●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.63; Pearson R:−0.17
●
●
P−value:0.19; Pearson R:0.46
●
●
●
−1.1
0.8 0.6
●
● ● ●
DLG1
●
●
P−value:0.95; Pearson R:0.025
1.0
●
●
0.4
ARHGEF12
1.2
●
−0.5
Zhai Cervix : Normal−Cervix squamos
P−value:0.62; Pearson R:−0.18
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.5
●
●
●
1.0
1.5
2.0
2.5
0.7 0.6
● ●
●
●
●
0.5
1.0
1.5
2.0
2.5
BCL6
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
−1.4
●
● ●
−0.6
−0.4
●
−0.2
0.0
0.7 0.6
● ●
0.5
●
●
●
●
● ●
●
●
0.4
●
3.0
●
DLG3
●
−1.2
●
P−value:0.33; Pearson R:0.35
BCL6
−0.8 −1.0
●
3.0
●
DLG2
●
●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.035; Pearson R:0.67
−1.4
●
●
0.5
●
●
●
0.4
●
●
DLG3
−1.0
●
●
−1.2
DLG2
−0.8
●
P−value:0.69; Pearson R:−0.15
Zhai Cervix : Normal−Cervix squamos
P−value:0.34; Pearson R:−0.34
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
●
−2.5
●
1.0
1.5
2.0
2.5
0.4 0.0
●
● ●
0.5
1.0
1.5
2.0
2.5
Zhai Cervix : Normal−Cervix squamos
−2.0
●
●
−0.6
−0.4
−0.2
0.0
0.0
● ● ● ●
●
−0.4
●
●
●
−0.8
−1.5
●
●
3.0
●
FYN
−1.0
●
0.4
Zhai Cervix : Normal−Cervix squamos
P−value:0.072; Pearson R:0.59
BCL6
●
−2.5
●
BCL6
●
DLG4
● ●
3.0
●
●
●
●
●
0.5
●
−0.4
●
−0.8
●
● ●
●
FYN
−1.5
●
P−value:0.5; Pearson R:0.24
●
−2.0
DLG4
−1.0
●
● ●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.69; Pearson R:0.14
Zhai Cervix : Normal−Cervix squamos
P−value:0.15; Pearson R:−0.49
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−0.2
● ●
0.5
1.0
1.5
●
●
2.0
2.5
3.7
●
●
● ● ●
●
3.0
0.5
1.0
1.5
2.0
2.5
BCL6
BCL6
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
●
0.0
●
●
−0.2
●
●
−0.6
●
●
−0.4
−0.2
0.0
3.7
●
●
● ●
● ●
3.5
●
●
3.3
●
3.0
●
●
LLGL2
0.2
0.4
●
LLGL1
●
●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.25; Pearson R:0.4
●
●
3.5
●
●
3.3
●
●
LLGL2
●
P−value:0.55; Pearson R:0.21
0.2
●
0.0
LLGL1
0.4
●
P−value:0.46; Pearson R:0.26
Zhai Cervix : Normal−Cervix squamos
P−value:0.18; Pearson R:−0.47
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
0.2
●
●
0.5
1.0
1.5
2.0
2.5
−0.8
●
0.5
1.0
1.5
2.0
2.5
BCL6
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
●
0.6
●
● ●
●
●
−0.6
−0.4
−0.2
0.0
−0.8
●
●
●
−1.2
●
● ●
3.0
●
● ●
−1.6
●
●
MAP2K7
1.0 0.8
●
P−value:0.078; Pearson R:0.58
BCL6
0.2
0.4
●
3.0
●
MAP2K4
●
●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.27; Pearson R:−0.38
0.6
● ●
●
●
●
−1.2
●
●
● ●
−1.6
●
●
●
●
MAP2K7
0.8
●
0.4
MAP2K4
1.0
●
P−value:0.34; Pearson R:0.34
Zhai Cervix : Normal−Cervix squamos
P−value:0.83; Pearson R:0.077
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
1.0
●
●
0.5
●
1.0
1.5
2.0
2.5
−0.5
● ●
0.5
●
1.0
1.5
2.0
2.5
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
●
●
●
●
−0.6
●
−0.4
−0.2
0.0
●
●
−0.5
● ●
−1.0
●
−1.5
●
3.0
●
MAPK8
1.8 1.6
●
0.0
BCL6
P−value:0.33; Pearson R:0.35
BCL6
●
1.4 1.2
●
3.0
●
1.0
MAPK10
●
●
●
● ●
−0.6
ZBTB7A
●
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.82; Pearson R:0.083
●
● ●
P−value:0.71; Pearson R:−0.14
●
●
●
−1.0
1.4
●
● ●
−1.5
●
1.2
MAPK10
1.6
●
MAPK8
1.8
●
0.0
Zhai Cervix : Normal−Cervix squamos
P−value:0.41; Pearson R:0.29
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−1.0
● ●
1.0
1.5
2.0
2.5
3.6
● ● ●
3.4
●
3.0
0.5
1.0
1.5
2.0
2.5
BCL6
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
−0.6
●
● ● ●
−0.6
−0.4
−0.2
0.0
3.6 3.4
●
●
●
3.2
● ●
3.0
●
● ●
●
●
●
●
2.8
●
3.0
●
SCRIB
●
P−value:0.97; Pearson R:0.012
BCL6
−1.0
MAPK9
−0.2 0.0
0.5
●
●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.55; Pearson R:−0.22
●
●
P−value:0.98; Pearson R:−0.0084
●
● ●
3.2
●
●
3.0
●
●
●
2.8
●
●
SCRIB
●
P−value:0.79; Pearson R:−0.099
Zhai Cervix : Normal−Cervix squamos
−0.6
MAPK9
−0.2 0.0
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
−2.5
●
1.0
1.5
2.0
2.5
1.8
0.5
1.0
1.5
2.0
2.5
BCL6
Zhai Cervix : Normal−Cervix squamos
Zhai Cervix : Normal−Cervix squamos
● ●
−1.5
●
−2.0
●
●
−0.6
−0.4
−0.2
0.0
●
1.8
●
3.0
●
1.6
●
● ●
● ● ● ●
1.4
●
1.2
−1.0
●
BCL6
●
−2.5
●
3.0
●
SRC
●
●
YES1
−0.5
0.5
● ●
●
●
−0.6
ZBTB7A
−0.4
−0.2
ZBTB7A
Biology Open | Supplementary Material
0.0
P−value:0.45; Pearson R:0.27
●
● ●
1.6
●
●
●
1.4
●
P−value:0.67; Pearson R:−0.15
−1.5
●
●
−2.0
SRC
−1.0
●
●
1.2
●
YES1
●
P−value:0.33; Pearson R:0.35
Zhai Cervix : Normal−Cervix squamos
P−value:0.94; Pearson R:0.029
−0.5
Zhai Cervix : Normal−Cervix squamos
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
Supplementary Table 1: All significant correlations in gene expression Gene expression datasets
Gasper colon all Gaspar colorectal adenoma Gaspar colon normal Rohrbeck all-Lung (cancer only) Boersma Breast all Tomlins Prostate all Tomlins Prostate Carcinoma Zhai Cervix all Grutzmann Pancreas normal Grutzmann Pancreas all (no met) Boersma Breast all Grutzmann Pancreas normal Ma Breast 4 all Toruner Head-Neck all oral squamous carcinoma (cancer only) Grutzmann Pancreatic ductal adenocarcinoma Boersma Breast all Rohrbeck all-Lung (cancer only) Zhai Cervix all Zhai Cervix Cervical squamous Collisson Pancreas all-adenocarcinoma Rohrbeck all-Lung (cancer only) Tomlins Prostate all Grutzmann Pancreas normal Grutzmann Pancreas all (no met) Gasper colon all Gaspar colorectal adenoma Gaspar colon normal Rohrbeck all-Lung (cancer only) Zhai Cervix Cervical squamous Boersma Breast all Boersma Breast all Skrzypczak Colorectal 2 colon adenoma Zhai Cervix Normal-Cervix squamous Grutzmann Pancreas all (no met) Boersma Breast all Ma Breast 4 normal Tomlins Prostate all Toruner Head-Neck all oral squamous carcinoma (cancer only)
BTB-Zn gene
Polarity or cytoskeletal gene Bcl6 ARHGEF1 Bcl6 ARHGEF1 Bcl6 ARHGEF1 Bcl6 ARHGEF1 ZBTB7A ARHGEF1 Bcl6 ARHGEF11 Bcl6 ARHGEF11 Bcl6 ARHGEF11 Bcl6 ARHGEF11 Bcl6 ARHGEF11 ZBTB7A ARHGEF11 Bcl6 ARHGEF12 Bcl6 ARHGEF12
P value
Pearson Notes R
1,00E-06 1,10E-05 1,60E-02 3,30E-02 1,00E-02 5,60E-03 1,40E-02 2,20E-02 3,70E-02 4,50E-02 2,80E-04 4,90E-02 2,40E-02
-0,52 -0,55 -0,51 -0,33 0,26 0,45 0,57 -0,37 -0,63 -0,43 -0,37 -0,6 0,28
A
ZBTB7A ZBTB7A ZBTB7A Bcl6 Bcl6 Bcl6 Bcl6 ZBTB7A ZBTB7A ZBTB7A ZBTB7A Bcl6
ARHGEF12 ARHGEF12 ARHGEF12 DLG1 DLG1 DLG1 DLG1 DLG1 DLG1 DLG1 DLG1 DLG2
1,70E-02 2,20E-02 5,90E-10 1,10E-03 2,10E-02 6,00E-03 4,60E-02 4,70E-02 3,70E-02 1,60E-02 1,30E-02 2,20E-15
0,59 -0,68 0,58 0,49 0,37 0,51 0,39 -0,31 0,74 0,7 0,52 -0,75
*
Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 ZBTB7A Bcl6 ZBTB7A ZBTB7A ZBTB7A ZBTB7A Bcl6
DLG2 DLG2 DLG2 DLG2 DLG2 DLG2 DLG3 DLG3 DLG3 DLG3 DLG3 DLG4
7,40E-13 8,40E-04 2,00E-02 4,90E-02 1,20E-02 7,90E-03 2,40E-02 3,50E-02 1,90E-02 5,10E-05 5,10E-04 8,60E-05
-0,79 -0,66 -0,36 0,38 0,26 -0,27 -0,7 0,67 -0,5 -0,4 0,61 0,69
*, # N *
ZBTB7A DLG4
5,70E-02
0,48
Biology Open | Supplementary Material
N A A A *, # A N A A N A
A A
A N A A
A A N A A N A
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
Grutzmann Pancreas normal Grutzmann Pancreas all (no met) Gasper colon all Gaspar colorectal adenoma Skrzypczak Colorectal 2 colon adenoma Tomlins Prostate all Tomlins Prostate Normal-Prostate Gland Boersma Breast all Gasper colon all Gaspar colorectal adenoma Gaspar colon normal Rohrbeck all-Lung (cancer only) Zhai Cervix all Ma Breast 4 all Ma Breast 4 normal Ma Breast 4 primary ductal breast carcinoma Ma Breast 2 all breast carcinoma Gasper colon all Gaspar colorectal adenoma Skrzypczak Colorectal 2-all Epithelia Skrzypczak Colorectal 2-all Epithelia Boersma Breast all Ma Breast 4 normal Toruner Head-Neck all oral squamous carcinoma (cancer only) Boersma Breast normal Tomlins Prostate Carcinoma Gaspar colon normal Tomlins Prostate all Tomlins Prostate Carcinoma Grutzmann Pancreas normal Grutzmann Pancreas all (no met) Grutzmann Pancreas all (no met) Gasper colon all Gaspar colorectal adenoma Gaspar colon normal Collisson Pancreas all-adenocarcinoma Grutzmann Pancreas normal Ma Breast 4 normal Skrzypczak Colorectal 2-all Epithelia Boersma Breast all Boersma Breast normal Gaspar colorectal adenoma Grutzmann Pancreas all (no met) Grutzmann Pancreas normal Ma Breast 4 all
ZBTB7A ZBTB7A Bcl6 Bcl6 Bcl6 ZBTB7A ZBTB7A ZBTB7A Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 ZBTB7A Bcl6 Bcl6 Bcl6 ZBTB7A ZBTB7A ZBTB7A
DLG4 DLG4 FYN FYN FYN FYN FYN FYN LLGL1 LLGL1 LLGL1 LLGL1 LLGL1 LLGL1 LLGL1 LLGL1 LLGL1 LLGL2 LLGL2 LLGL2 LLGL2 LLGL2 LLGL2
2,30E-02 2,20E-02 1,70E-06 8,30E-07 6,90E-03 6,60E-03 9,10E-03 2,50E-03 4,40E-15 2,60E-11 4,60E-05 3,80E-03 3,50E-02 1,30E-03 1,80E-02 3,90E-02 3,20E-02 0,036 9,00E-04 3,70E-02 1,80E-02 1,20E-04 1,90E-02
0,67 0,49 -0,51 -0,6 -0,79 0,6 0,84 0,31 0,75 0,75 0,76 -0,44 -0,34 0,39 0,44 0,34 0,34 0,24 0,43 -0,47 0,52 -0,38 0,44
N A A
Bcl6 Bcl6 ZBTB7A Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 ZBTB7A Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 Bcl6 ZBTB7A ZBTB7A ZBTB7A Bcl6 Bcl6 Bcl6 Bcl6
MAPK10 MAPK10 MAPK10 MAPK8 MAPK8 MAPK8 MAPK8 MAPK8 MAPK8 MAPK9 MAPK9 MAPK9 MAPK9 MAPK9 MAPK9 MAPK9 MAPK9 MAPK9 MAP2K4 MAP2K4 MAP2K4 MAP2K4
1,10E-02 5,00E-02 3,40E-03 2,50E-02 2,00E-02 2,20E-02 2,10E-03 6,30E-03 1,10E-02 3,20E-13 4,40E-09 3,10E-06 8,00E-03 1,50E-02 6,30E-03 1,10E-02 9,90E-08 1,10E-02 6,80E-03 8,50E-03 4,00E-03 3,40E-03
0,62 0,29 -0,85 -0,48 0,46 0,57 -0,82 -0,56 0,53 0,71 0,69 0,82 -0,5 0,71 -0,5 0,55 -0,51 -0,37 0,36 0,55 0,79 -0,36
* N
Biology Open | Supplementary Material
A N A A N * A A N
A A A A N
N A * N A A A *, # N N N A A N *, # A N A
Biology Open (2015): doi:10.1242/bio.012815: Supplementary Material
Ma Breast 4 normal Bcl6 MAP2K4 1,20E-03 -0,58 Rohrbeck all-Lung (cancer only) Bcl6 MAP2K4 2,50E-03 0,45 Zhai cervix all ZBTB7A MAP2K4 3,20E-02 0,35 Boersma Breast epithelial cancer Bcl6 MAP2K7 2,30E-03 0,43 Gaspar colorectal adenoma Bcl6 MAP2K7 2,20E-02 -0,31 Rohrbeck all-Lung (cancer only) Bcl6 MAP2K7 6,20E-04 -0,51 Grutzmann Pancreas all (no met) Bcl6 MAP2K7 2,40E-03 -0,61 Grutzmann Pancreas normal Bcl6 MAP2K7 9,90E-03 -0,74 Grutzmann Pancreatic ductal adenocarcinoma ZBTB7A MAP2K7 5,10E-02 0,6 Grutzmann Pancreas all (no met) ZBTB7A MAP2K7 1,20E-02 0,52 Zhai Cervix Cervical squamous ZBTB7A MAP2K7 1,30E-02 0,46 Zhai Cervix all ZBTB7A SCRIB 3,40E-02 0,34 Ma Breast 4 all ZBTB7A SCRIB 1,10E-02 0,31 Ma Breast 4 normal ZBTB7A SCRIB 2,00E-02 0,44 Gasper colon all Bcl6 SRC 1,70E-10 -0,65 Gaspar colorectal adenoma Bcl6 SRC 5,30E-08 -0,65 Gaspar colon normal Bcl6 SRC 1,60E-03 -0,63 Grutzmann Pancreas normal Bcl6 SRC 1,40E-02 -0,71 Grutzmann Pancreas all (no met) Bcl6 SRC 3,00E-02 -0,46 Collisson Pancreas all-adenocarcinoma ZBTB7A SRC 3,10E-02 0,42 Grutzmann Pancreas normal ZBTB7A SRC 2,70E-03 0,81 Grutzmann Pancreas all (no met) ZBTB7A SRC 3,10E-04 0,7 Gasper colon all Bcl6 YES1 1,60E-05 0,47 Gaspar colorectal adenoma Bcl6 YES1 1,40E-04 0,49 Gaspar colon normal Bcl6 YES1 3,40E-02 0,45 Rohrbeck all-Lung (cancer only) Bcl6 YES1 9,60E-03 0,4 Zhai Cervix all Bcl6 YES1 4,70E-02 0,32 Grutzmann Pancreas normal Bcl6 YES1 5,60E-04 0,87 Grutzmann Pancreas all (no met) Bcl6 YES1 8,40E-04 0,66 Boersma Breast all Bcl6 YES1 5,00E-03 -0,29 Boersma Breast epithelial cancer Bcl6 YES1 1,40E-02 -0,35 Skrzypczak Colorectal 2-all Epithelia ZBTB7A YES1 1,60E-02 0,53 Red = positive correlation, Blue = negative correlation, Brown = borderline significance with positive correlation, A = All (normal & cancer), N= Normal, * Bcl6/ZBTB7 high and correlated as expected with the test gene (highlighted in green), # Trend is stronger in cancer compared with normal tissue (highlighted in yellow)
Biology Open | Supplementary Material
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A N *, # A *, # A A N A N N A * N A A *, # N * A N A A A
