Sparse Permutation Invariant Covariance Estimation: Motivation ...

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Sparse Permutation Invariant Covariance Estimation: Motivation, Background and Key Results David Prince Biostat 572 [email protected]

April 19, 2012

David Prince (UW)

SPICE

April 19, 2012

1 / 11

Electronic Journal of Statistics Vol. 2 (2008) 494–515 ISSN: 1935-7524 DOI: 10.1214/08-EJS176

Sparse permutation invariant covariance estimation Adam J. Rothman University of Michigan Ann Arbor, MI 48109-1107 e-mail: [email protected]

Peter J. Bickel University of California Berkeley, CA 94720-3860 e-mail: [email protected]

Elizaveta Levina∗ University of Michigan Ann Arbor, MI 48109-1107 e-mail: [email protected]

Ji Zhu University of Michigan Ann Arbor, MI 48109-1107 e-mail: [email protected]

David Prince (UW)

Abstract: The paper proposes a method for constructing a sparse estimator for the inverse covariance (concentration) matrix in high-dimensional settings. The estimator uses a penalized normal likelihood approach and forces sparsity by using a lasso-type penalty. We establish a rate of conSPICE vergence in the Frobenius norm as both data dimension p and sample size

April 19, 2012

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Motivation

Reductionism vs. Dynamism Gene-gene interaction networks High-dimensional setting, i.e. n

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