Additional File 3

2168 IL8:952 4000 8000

0

2395 CDKN1A:99 400 800

0

2783 IGHG3:203 400 800 1200

0

2786 IGKC:518 1000 2000

0

2789 BRCA1:252 400 800

0

0

0

0

0

0

Slp = 1.53 Intcpt = -52

20 40 60 80 2788 BRCA1:173

Slp = 1.47 Intcpt = 409

500 1500 2785 IGKC:277 NM_007305 BRCA1

M63438 IGKC

200 600 2782 IGHG3:485

Slp = 1.66 Intcpt = -1

200 400 600 1340 CDKN1A:384 M87789 IGHG3

Slp = 1.66 Intcpt = -4

4000 8000 1498 IL8:302 NM_000389 CDKN1A

Slp = 0.67 Intcpt = -115

NM_000584 IL8

2799 IL8:350 4000 8000

0

2859 CDKN1A:523 0 20 60 100

2784 IGHG3:601 500 1000 1500

0

2787 IGKC:110 0 1000 3000

2790 BRCA1:74 50 100 150

0 0

0

0

0

0

Slp = 2.02 Intcpt = -61

20 40 60 80 2788 BRCA1:173

Slp = 1.91 Intcpt = 1

500 1500 2785 IGKC:277 NM_007305 BRCA1

M63438 IGKC

200 600 2782 IGHG3:485

Slp = 1.79 Intcpt = -40

200 400 600 1340 CDKN1A:384 M87789 IGHG3

Slp = 0.09 Intcpt = 35

4000 8000 1498 IL8:302 NM_000389 CDKN1A

Slp = 0.82 Intcpt = -250

NM_000584 IL8 2799 IL8:350 4000 8000 0 2859 CDKN1A:523 0 20 60 100 2784 IGHG3:601 500 1000 1500 0 2787 IGKC:110 0 1000 3000 2790 BRCA1:74 50 100 150 0 0

0

0

0

0

Slp = 1.27 Intcpt = 24

400 800 2789 BRCA1:252

Slp = -0.01 Intcpt = 50

1000 2000 2786 IGKC:518 NM_007305 BRCA1

M63438 IGKC

400 800 1200 2783 IGHG3:203

Slp = 1.06 Intcpt = -42

400 800 2395 CDKN1A:99 M87789 IGHG3

Slp = 0.05 Intcpt = 37

4000 8000 2168 IL8:952 NM_000389 CDKN1A

Slp = 1.23 Intcpt = -116

NM_000584 IL8

4 2168 IL8:952 1 2 3 2395 CDKN1A:99 1.5 2.0 2.5 3.0 2783 IGHG3:203 1.0 2.0 3.0 0.0 2786 IGKC:518 0.5 1.5 2.5 3.5 2789 BRCA1:252 2.5 2.7 2.9

2.0 2.5 3.0 2785 IGKC:277 NM_007305 BRCA1

1.5

M63438 IGKC

1.5 2.0 2.5 2782 IGHG3:485

1.6 2.0 2.4 2.8 1340 CDKN1A:384 M87789 IGHG3

2.5 3.0 3.5 4.0 1498 IL8:302 NM_000389 CDKN1A

NM_000584 IL8

0.0 0.5 1.0 1.5 2.0 2788 BRCA1:173

2.3

2799 IL8:350 2.5 3.5 1.5 2859 CDKN1A:523 1.4 1.6 1.8 2.0 2784 IGHG3:601 1.0 2.0 3.0 0.0 2787 IGKC:110 1.5 2.5 3.5

2.0 2.5 3.0 2785 IGKC:277 NM_007305 BRCA1

1.5

M63438 IGKC

1.5 2.0 2.5 2782 IGHG3:485

1.6 2.0 2.4 2.8 1340 CDKN1A:384 M87789 IGHG3

2.5 3.0 3.5 4.0 1498 IL8:302 NM_000389 CDKN1A

NM_000584 IL8

0.0 0.5 1.0 1.5 2.0 2788 BRCA1:173

2790 BRCA1:74 0.5 1.0 1.5 2.0

2799 IL8:350 2.5 3.5 1.5

1 2 3 2168 IL8:952 NM_000389 CDKN1A

NM_000584 IL8

4

2.3

2.5 2.7 2.9 2789 BRCA1:252

0.5 1.5 2.5 3.5 2786 IGKC:518 NM_007305 BRCA1

M63438 IGKC

0.0

1.0 2.0 3.0 2783 IGHG3:203

1.5 2.0 2.5 3.0 2395 CDKN1A:99 M87789 IGHG3

2859 CDKN1A:523 1.4 1.6 1.8 2.0 2784 IGHG3:601 1.0 2.0 3.0

0.0 2787 IGKC:110 1.5 2.5 3.5 2790 BRCA1:74 0.5 1.0 1.5 2.0

2791 BTN3A2:173 0 100 300

2794 GBE1:499 0 50 150 250

2797 HSPD1:464 200 600

0

2801 JUND:194 0 100 300

2804 MYH10:174 1000 2000 3000

0

0

0

0

0

0

500 1000 2803 MYH10:52

Slp = 1.82 Intcpt = 138

2000 4000 6000 2800 JUND:95 NM_005964 MYH10

Slp = 0.07 Intcpt = 57

NM_005354 JUND

500 1500 2796 HSPD1:129

Slp = 0.36 Intcpt = -28

500 1000 1500 2793 GBE1:129 NM_002156 HSPD1

Slp = 0.17 Intcpt = -10

100 200 300 1635 BTN3A2:123 NM_000158 GBE1

Slp = 1.22 Intcpt = 6

NM_007047 BTN3A2

2792 BTN3A2:63 50 150 250

0

2795 GBE1:191 500 1500

0

2798 HSPD1:393 400 800 1200

0

2802 JUND:277 500 1000 1500

0

2805 MYH10:336 1000 2500

0 0

0

0

0

0

500 1000 2803 MYH10:52

Slp = 1.96 Intcpt = 122

2000 4000 6000 2800 JUND:95 NM_005964 MYH10

Slp = 0.27 Intcpt = 62

NM_005354 JUND

500 1500 2796 HSPD1:129

Slp = 0.54 Intcpt = -41

500 1000 1500 2793 GBE1:129 NM_002156 HSPD1

Slp = 1.09 Intcpt = -4

100 200 300 1635 BTN3A2:123 NM_000158 GBE1

Slp = 0.77 Intcpt = -25

NM_007047 BTN3A2

2792 BTN3A2:63 50 150 250 0 2795 GBE1:191 500 1500 0 2798 HSPD1:393 400 800 1200 0 2802 JUND:277 500 1000 1500 0 2805 MYH10:336 1000 2500 0

Slp = 3.02 Intcpt = 33

NM_005354 JUND

200 600 2797 HSPD1:464

0

1000 2000 3000 2804 MYH10:174

Slp = 1.08 Intcpt = -23

0 100 300 2801 JUND:194 NM_005964 MYH10

0

Slp = 1.45 Intcpt = 23

0 50 150 250 2794 GBE1:499 NM_002156 HSPD1

Slp = 6.25 Intcpt = 69

0 100 300 2791 BTN3A2:173 NM_000158 GBE1

Slp = 0.57 Intcpt = -20

NM_007047 BTN3A2 2791 BTN3A2:173 1.6 2.0 2.4 2.6

2.0 2.5 3.0 2803 MYH10:52

3.0 3.4 2800 JUND:95 NM_005964 MYH10

NM_005354 JUND

2.0 2.5 3.0 2796 HSPD1:129

3.8

2.4 2.8 3.2 2793 GBE1:129 NM_002156 HSPD1

1.8 2.2 1635 BTN3A2:123 NM_000158 GBE1

NM_007047 BTN3A2

2.0

2794 GBE1:499 1.2 1.6 2.0 2.4 2797 HSPD1:464 1.5 2.0 2.5 2801 JUND:194 2.0 2.2 2.4 2.6 2804 MYH10:174 2.5 3.0 3.5 2.0

2792 BTN3A2:63 1.2 1.6 2.0 2.4 2795 GBE1:191 2.4 2.8 3.2 2.6

2.0 2.5 3.0 2803 MYH10:52

3.0 3.4 2800 JUND:95 NM_005964 MYH10

NM_005354 JUND

2.0 2.5 3.0 2796 HSPD1:129

3.8

2.4 2.8 3.2 2793 GBE1:129 NM_002156 HSPD1

1.8 2.2 1635 BTN3A2:123 NM_000158 GBE1

NM_007047 BTN3A2

2.0

2.0 2798 HSPD1:393 1.5 2.0 2.5 3.0 2802 JUND:277 2.4 2.8 3.2 2805 MYH10:336 2.5 3.0 3.5 2.0

NM_007047 BTN3A2

2.0

2.5 3.0 3.5 2804 MYH10:174

2.0 2.2 2.4 2.6 2801 JUND:194 NM_005964 MYH10

NM_005354 JUND

1.5 2.0 2.5 2797 HSPD1:464

1.2 1.6 2.0 2.4 2794 GBE1:499 NM_002156 HSPD1

1.6 2.0 2.4 2791 BTN3A2:173 NM_000158 GBE1

2792 BTN3A2:63 1.2 1.6 2.0 2.4 2795 GBE1:191 2.4 2.8 3.2

2.0 2798 HSPD1:393 1.5 2.0 2.5 3.0 2802 JUND:277 2.4 2.8 3.2 2805 MYH10:336 2.5 3.0 3.5 2.0

2813 ALDH1A3:148 0 2000 6000

2816 AMOTL2:49 2 4 6 8

0

2819 APOE:869 0 100 300

2821 ATG3:639 0 50 150 250

2824 ATP1B3:561 400 800 1200

0

0

0

200 400 600 2823 ATP1B3:715

Slp = 1.64 Intcpt = 84

200 400 2820 ATG3:368 NM_001679 ATP1B3

Slp = 0.48 Intcpt = -8

NM_022488 ATG3

0 200 600 2818 APOE:96

Slp = 0.45 Intcpt = 3

0 5 15 25 2815 AMOTL2:439 NM_000041 APOE

Slp = 0.05 Intcpt = 5

0 2000 5000 2812 ALDH1A3:476 NM_016201 AMOTL2

Slp = 1.12 Intcpt = 64

NM_000693 ALDH1A3

2814 ALDH1A3:330 0 2000 6000

2817 AMOTL2:683 400 800 1200

0

2822 ATG3:785 100 200 300

0

2825 ATP1B3:193 40 80 120

0 0

0

200 400 600 2823 ATP1B3:715

Slp = 0.12 Intcpt = 12

200 400 2820 ATG3:368 NM_001679 ATP1B3

Slp = 0.67 Intcpt = -4

NM_022488 ATG3

0 5 15 25 2815 AMOTL2:439

Slp = 31.79 Intcpt = 205

0 2000 5000 2812 ALDH1A3:476 NM_016201 AMOTL2

Slp = 1.21 Intcpt = 55

NM_000693 ALDH1A3 2814 ALDH1A3:330 0 2000 6000 2817 AMOTL2:683 400 800 1200 0

Slp = 1.38 Intcpt = 9

NM_022488 ATG3

2 4 6 8 2816 AMOTL2:49

0

400 800 1200 2824 ATP1B3:561

Slp = 0.07 Intcpt = 5

0 50 150 250 2821 ATG3:639 NM_001679 ATP1B3

0

Slp = 186.38 Intcpt = -372

0 2000 6000 2813 ALDH1A3:148 NM_016201 AMOTL2

Slp = 1.07 Intcpt = -9

NM_000693 ALDH1A3

2.1

2.3 2.5 2.7 2820 ATG3:368 NM_001679 ATP1B3

NM_022488 ATG3

1.5 2.0 2.5 3.0 2818 APOE:96

2.0 2.2 2.4 2.6 2.8 2823 ATP1B3:715

2.1

2.3 2.5 2.7 2820 ATG3:368 NM_001679 ATP1B3

NM_022488 ATG3

2.0 2.2 2.4 2.6 2.8 2823 ATP1B3:715

2.4 2.6 2.8 3.0 2824 ATP1B3:561

1.8 2.0 2.2 2.4 2821 ATG3:639 NM_001679 ATP1B3

NM_022488 ATG3

0.4 0.8 2816 AMOTL2:49

0.0

0.0 0.5 1.0 1.5 2815 AMOTL2:439

0.0 0.5 1.0 1.5 2815 AMOTL2:439 NM_000041 APOE

NM_000693 ALDH1A3

1.0 2.0 3.0 2813 ALDH1A3:148 NM_016201 AMOTL2

NM_000693 ALDH1A3

1.5 2.5 3.5 2812 ALDH1A3:476 NM_016201 AMOTL2

NM_000693 ALDH1A3

1.5 2.5 3.5 2812 ALDH1A3:476 NM_016201 AMOTL2

2813 ALDH1A3:148 1.0 2.0 3.0 2816 AMOTL2:49 0.4 0.8 0.0 2819 APOE:869 1.5 2.0 2.5 1.0 2821 ATG3:639 1.8 2.0 2.2 2.4 2824 ATP1B3:561 2.4 2.6 2.8 3.0

2822 ATG3:785 100 200 300

2814 ALDH1A3:330 0.5 1.5 2.5 3.5 2817 AMOTL2:683 2.4 2.6 2.8 3.0 2822 ATG3:785 2.0 2.2 2.4 1.8 2825 ATP1B3:193 1.2 1.4 1.6 1.8 2.0

0 2825 ATP1B3:193 40 80 120 0

2814 ALDH1A3:330 0.5 1.5 2.5 3.5 2817 AMOTL2:683 2.4 2.6 2.8 3.0

2822 ATG3:785 2.0 2.2 2.4 1.8 2825 ATP1B3:193 1.2 1.4 1.6 1.8 2.0

2827 BDKRB1:199 400 800 1200

0

2830 BRCA2:315 0 20 60 100

2833 C1QTNF1:524 0 10 30 50

2836 CD24:171 4000 8000

0

2839 CD300A:732 5 10 15 20 25

0

Slp = 1.13 Intcpt = 28

500 1500 2826 BDKRB1:100 NM_000059 BRCA2

Slp = 0.00 Intcpt = 10

2000 5000 2835 CD24:94 NM_007261 CD300A

0 100 300 500 2838 CD300A:211

0

Slp = 1.17 Intcpt = -473

NM_013230 CD24

0 100 200 300 2832 C1QTNF1:161

Slp = 0.14 Intcpt = 4

0 5 15 25 35 2829 BRCA2:51 NM_198594 C1QTNF1

0

Slp = 0.70 Intcpt = -84

NM_000710 BDKRB1

2828 BDKRB1:497 500 1500

0

2831 BRCA2:185 40 80 120

0

2834 C1QTNF1:80 200 400 600

0

2837 CD24:314 0 2000 6000

2840 CD300A:128 20 40 60

0

Slp = 3.49 Intcpt = 0

500 1500 2826 BDKRB1:100 NM_000059 BRCA2

Slp = 0.01 Intcpt = 30

2000 5000 2835 CD24:94 NM_007261 CD300A

0 100 300 500 2838 CD300A:211

0

Slp = 1.00 Intcpt = -430

NM_013230 CD24

0 100 200 300 2832 C1QTNF1:161

Slp = 1.62 Intcpt = 142

0 5 15 25 35 2829 BRCA2:51 NM_198594 C1QTNF1

0

Slp = 1.24 Intcpt = -136

NM_000710 BDKRB1 2828 BDKRB1:497 500 1500 0 2831 BRCA2:185 40 80 120 0 2834 C1QTNF1:80 200 400 600 0 2837 CD24:314 0 2000 6000 2840 CD300A:128 20 40 60 0

Slp = 0.36 Intcpt = 11

400 800 1200 2827 BDKRB1:199 NM_000059 BRCA2

0

0

5 10 15 20 25 2839 CD300A:732

Slp = 2.97 Intcpt = -4

4000 8000 2836 CD24:171 NM_007261 CD300A

Slp = 0.89 Intcpt = -114

NM_013230 CD24

0 10 30 50 2833 C1QTNF1:524

Slp = 6.15 Intcpt = 227

0 20 60 100 2830 BRCA2:315 NM_198594 C1QTNF1

0

Slp = 1.77 Intcpt = 12

NM_000710 BDKRB1

2827 BDKRB1:199 1.0 2.0 3.0 0.5 1.0 1.5 2829 BRCA2:51 NM_198594 C1QTNF1

2.0 2.4 2.8 3.2 2826 BDKRB1:100 NM_000059 BRCA2

NM_000710 BDKRB1

0.0

2830 BRCA2:315 1.2 1.4 1.6 1.8 2.0 1.6 2.0 2.4 2838 CD300A:211

1.5 2.5 3.5 2835 CD24:94 NM_007261 CD300A

NM_013230 CD24

0.0 1.0 2.0 2832 C1QTNF1:161

2833 C1QTNF1:524 0.0 0.5 1.0 1.5 2836 CD24:171 1 2 3 4 0 2839 CD300A:732 0.0 0.4 0.8 1.2

2828 BDKRB1:497 1.0 2.0 3.0 1.6 2.0 2.4 2838 CD300A:211

1.5 2.5 3.5 2835 CD24:94 NM_007261 CD300A

NM_013230 CD24

0.0 1.0 2.0 2832 C1QTNF1:161

0.5 1.0 1.5 2829 BRCA2:51 NM_198594 C1QTNF1

2.0 2.4 2.8 3.2 2826 BDKRB1:100 NM_000059 BRCA2

NM_000710 BDKRB1

0.0

2831 BRCA2:185 0.0 0.5 1.0 1.5 2.0 2834 C1QTNF1:80 2.0 2.2 2.4 2.6 2.8

2837 CD24:314 1.5 2.5 3.5 0.5 2840 CD300A:128 0.0 0.5 1.0 1.5

2828 BDKRB1:497 1.0 2.0 3.0

1.0 2.0 3.0 2827 BDKRB1:199 NM_000059 BRCA2

NM_000710 BDKRB1

1 2 3 2836 CD24:171 NM_007261 CD300A

0.0 0.4 0.8 1.2 2839 CD300A:732

0

NM_013230 CD24

0.0 0.5 1.0 1.5 2833 C1QTNF1:524

4

1.2 1.4 1.6 1.8 2.0 2830 BRCA2:315 NM_198594 C1QTNF1

2831 BRCA2:185 0.0 0.5 1.0 1.5 2.0

2834 C1QTNF1:80 2.0 2.2 2.4 2.6 2.8

2837 CD24:314 1.5 2.5 3.5 0.5 2840 CD300A:128 0.0 0.5 1.0 1.5

2842 CEP70:155 100 200 300

0

2845 CP:311 200 600

0

2848 CCL2:195 2000 4000

0

2851 COL1A1:112 0 2000 6000

2854 CCND2:183 400 800

0

0

0

500 1000 1500 2853 CCND2:49

Slp = 0.66 Intcpt = 22

500 1000 2850 COL1A1:659 NM_001759 CCND2

Slp = 4.40 Intcpt = 147

NM_000088 COL1A1

0 500 1500 2847 CCL2:357

Slp = 1.88 Intcpt = -112

2500

Slp = 0.34 Intcpt = -1

20 40 60 2841 CEP70:276 NM_000096 CP

0 500 1500 2844 CP:70 NM_002982 CCL2

0

Slp = 5.71 Intcpt = -10

NM_024491 CEP70

2843 CEP70:210 5 10 20 30

0

2846 CP:164 500 1000 1500

0

2849 CCL2:151 2000 6000

0

2852 COL1A1:373 1000 2000 3000

0

2855 CCND2:280 0 200 600 0

0

500 1000 1500 2853 CCND2:49

Slp = 0.53 Intcpt = 116

500 1000 2850 COL1A1:659 NM_001759 CCND2

Slp = 1.37 Intcpt = 138

NM_000088 COL1A1

0 500 1500 2847 CCL2:357

Slp = 3.27 Intcpt = -190

2500

Slp = 0.55 Intcpt = -2

20 40 60 2841 CEP70:276 NM_000096 CP

0 500 1500 2844 CP:70 NM_002982 CCL2

0

Slp = 0.21 Intcpt = 13

NM_024491 CEP70

2843 CEP70:210 5 10 20 30 0 2846 CP:164 500 1000 1500 0 2849 CCL2:151 2000 6000 0 2852 COL1A1:373 1000 2000 3000 0 2855 CCND2:280 0 200 600

Slp = 0.31 Intcpt = 92

NM_000088 COL1A1

2000 4000 2848 CCL2:195

Slp = 1.73 Intcpt = 12

200 600 2845 CP:311 NM_002982 CCL2

Slp = 1.60 Intcpt = 5

100 200 300 2842 CEP70:155 NM_000096 CP

0

400 800 2854 CCND2:183

Slp = 0.81 Intcpt = 96

0 2000 6000 2851 COL1A1:112 NM_001759 CCND2

0

0

0

Slp = 0.04 Intcpt = 12

NM_024491 CEP70 2842 CEP70:155 1.5 2.0 2.5 1.0 2845 CP:311 1.5 2.5

NM_024491 CEP70

0.5

1.5 2.5 2853 CCND2:49

1.0 2.0 3.0 2850 COL1A1:659 NM_001759 CCND2

NM_000088 COL1A1

2.0 2.5 3.0 2847 CCL2:357

1.5 2.5 2844 CP:70 NM_002982 CCL2

0.6 1.0 1.4 1.8 2841 CEP70:276 NM_000096 CP

0.5

0.5 2848 CCL2:195 1.5 2.5 3.5 2851 COL1A1:112 1.5 2.5 3.5 2854 CCND2:183 2.0 2.5 3.0 1.5

2843 CEP70:210 0.8 1.0 1.2 1.4 2846 CP:164 1.5 2.5

NM_024491 CEP70

0.5

1.5 2.5 2853 CCND2:49

1.0 2.0 3.0 2850 COL1A1:659 NM_001759 CCND2

NM_000088 COL1A1

2.0 2.5 3.0 2847 CCL2:357

1.5 2.5 2844 CP:70 NM_002982 CCL2

0.6 1.0 1.4 1.8 2841 CEP70:276 NM_000096 CP

0.5

0.5 2849 CCL2:151 2.5 3.5 1.5 2852 COL1A1:373 2.0 2.5 3.0 3.5 2855 CCND2:280 2.0 2.4 2.8

1.5

2.0 2.5 3.0 2854 CCND2:183

1.5 2.5 3.5 2851 COL1A1:112 NM_001759 CCND2

NM_000088 COL1A1

1.5 2.5 3.5 2848 CCL2:195

1.5 2.5 2845 CP:311 NM_002982 CCL2

1.5 2.0 2.5 2842 CEP70:155 NM_000096 CP

NM_024491 CEP70

0.5

1.0

2843 CEP70:210 0.8 1.0 1.2 1.4 2846 CP:164 1.5 2.5 0.5 2849 CCL2:151 2.5 3.5 1.5 2852 COL1A1:373 2.0 2.5 3.0 3.5 2855 CCND2:280 2.0 2.4 2.8

2857 CCND3:112 100 200 300

0

2861 DAPK1:205 100 200 300

0

2864 EVI1:740 100 200 300

0

2867 FSTL1:226 2000 4000

0

2870 HEG1:61 2000 4000

0

Slp = 0.30 Intcpt = -4

100 200 300 400 2860 DAPK1:318 NM_001105077 EVI1

Slp = 0.90 Intcpt = 3

200 400 600 2856 CCND3:495 NM_004938 DAPK1

0

0

2000 4000 2869 HEG1:239

Slp = 1.14 Intcpt = 100

2000 5000 2866 FSTL1:149 NM_020733 HEG1

Slp = 0.68 Intcpt = -148

NM_007085 FSTL1

0 200 600 2863 EVI1:85

0

0

Slp = 0.21 Intcpt = 61

NM_001760 CCND3

2858 CCND3:447 20 40 60 80

0

2862 DAPK1:441 40 80 120

0

2865 EVI1:278 500 1000

0

2868 FSTL1:97 2000 4000 6000

0

2871 HEG1:315 2000 4000

0

Slp = 1.72 Intcpt = -6

100 200 300 400 2860 DAPK1:318 NM_001105077 EVI1

Slp = 0.20 Intcpt = 22

200 400 600 2856 CCND3:495 NM_004938 DAPK1

0

0

2000 4000 2869 HEG1:239

Slp = 1.09 Intcpt = 31

2000 5000 2866 FSTL1:149 NM_020733 HEG1

Slp = 0.81 Intcpt = -48

NM_007085 FSTL1

0 200 600 2863 EVI1:85

0

0

Slp = 0.05 Intcpt = 10

NM_001760 CCND3 2858 CCND3:447 20 40 60 80 0 2862 DAPK1:441 40 80 120 0 2865 EVI1:278 500 1000 0 2868 FSTL1:97 2000 4000 6000 0 2871 HEG1:315 2000 4000 0 0

0

0

0

0

2000 4000 2870 HEG1:61

Slp = 0.94 Intcpt = -46

2000 4000 2867 FSTL1:226 NM_020733 HEG1

Slp = 1.19 Intcpt = 152

NM_007085 FSTL1

100 200 300 2864 EVI1:740

Slp = 5.54 Intcpt = 37

100 200 300 2861 DAPK1:205 NM_001105077 EVI1

Slp = 0.20 Intcpt = 24

100 200 300 2857 CCND3:112 NM_004938 DAPK1

Slp = 0.25 Intcpt = -5

NM_001760 CCND3

2857 CCND3:112 2.0 2.2 2.4 2.6 2.2

1.8 0.5

1.5

2.5 3.5 2869 HEG1:239

2.5 3.0 3.5 2866 FSTL1:149 NM_020733 HEG1

NM_007085 FSTL1

1.5 2.5 2863 EVI1:85

2.0 2.4 2860 DAPK1:318 NM_001105077 EVI1

2.4 2.6 2.8 2856 CCND3:495 NM_004938 DAPK1

NM_001760 CCND3

1.6

2861 DAPK1:205 1.6 2.0 2.4 2864 EVI1:740 1.0 2.0 0.0 2867 FSTL1:226 2.0 2.5 3.0 3.5 2870 HEG1:61 2.0 2.5 3.0 3.5

2.2

2858 CCND3:447 1.2 1.6 2.0 0.5

1.5

2.5 3.5 2869 HEG1:239

2.5 3.0 3.5 2866 FSTL1:149 NM_020733 HEG1

NM_007085 FSTL1

1.5 2.5 2863 EVI1:85

2.0 2.4 2860 DAPK1:318 NM_001105077 EVI1

2.4 2.6 2.8 2856 CCND3:495 NM_004938 DAPK1

NM_001760 CCND3

1.6

2862 DAPK1:441 1.4 1.6 1.8 2.0 2865 EVI1:278 1.0 2.0 3.0 2868 FSTL1:97 2.5 3.0 3.5 2871 HEG1:315 2.0 2.5 3.0 3.5

2.0 2.2 2.4 2.6 2857 CCND3:112 NM_004938 DAPK1

NM_001760 CCND3

1.0 2.0 2864 EVI1:740

2.0 2.5 3.0 3.5 2870 HEG1:61

2.0 2.5 3.0 3.5 2867 FSTL1:226 NM_020733 HEG1

NM_007085 FSTL1

0.0

1.6 2.0 2.4 2861 DAPK1:205 NM_001105077 EVI1

1.8

2858 CCND3:447 1.2 1.6 2.0 2862 DAPK1:441 1.4 1.6 1.8 2.0 2865 EVI1:278 1.0 2.0 3.0 2868 FSTL1:97 2.5 3.0 3.5 2871 HEG1:315 2.0 2.5 3.0 3.5

2873 IGFBP4:759 0 50 150 250

2876 ICAM2:69 10 20 30 40 50

0

2878 IL1B:638 400 800 1200

0

2880 IL18:626 100 200 300

0

2883 LXN:200 500 1500

0

Slp = 0.41 Intcpt = 19

NM_001562 IL18

2000 5000 1388 IL1B:156

Slp = 0.18 Intcpt = -20

10 20 30 40 2875 ICAM2:355 NM_000576 IL1B

Slp = 0.92 Intcpt = 13

400 800 1400 2872 IGFBP4:351 NM_001099786 ICAM2

0 200 600 1000 2882 LXN:301

Slp = 2.16 Intcpt = 76

0 200 600 1071 IL18:0 NM_020169 LXN

0

0

0

Slp = 0.18 Intcpt = 3

NM_001552 IGFBP4

2874 IGFBP4:681 50 150

0

2877 ICAM2:787 5 10 15

0

2879 IL1B:765 500 1500

0

2881 IL18:695 100 200 300

0

2884 LXN:252 500 1000

0

Slp = 0.39 Intcpt = 11

NM_001562 IL18

2000 5000 1388 IL1B:156

Slp = 0.28 Intcpt = -10

10 20 30 40 2875 ICAM2:355 NM_000576 IL1B

Slp = 0.38 Intcpt = 2

400 800 1400 2872 IGFBP4:351 NM_001099786 ICAM2

0 200 600 1000 2882 LXN:301

Slp = 1.86 Intcpt = 56

0 200 600 1071 IL18:0 NM_020169 LXN

0

0

0

Slp = 0.15 Intcpt = 1

NM_001552 IGFBP4 2874 IGFBP4:681 50 150 0 2877 ICAM2:787 5 10 15 0 2879 IL1B:765 500 1500 0 2881 IL18:695 100 200 300 0 2884 LXN:252 500 1000 0

Slp = 0.85 Intcpt = -4

100 200 300 2880 IL18:626 NM_020169 LXN

Slp = 0.88 Intcpt = -2

NM_001562 IL18

400 800 1200 2878 IL1B:638

Slp = 1.56 Intcpt = 31

10 20 30 40 50 2876 ICAM2:69 NM_000576 IL1B

0 500 1500 2883 LXN:200

0

0

0

Slp = 0.25 Intcpt = 0

0 50 150 250 2873 IGFBP4:759 NM_001099786 ICAM2

Slp = 0.79 Intcpt = 0

NM_001552 IGFBP4 2873 IGFBP4:759 1.4 1.8 2.2 1.0 0.5 1.0 1.5 2875 ICAM2:355 NM_000576 IL1B

1.5 2.0 2.5 3.0 2872 IGFBP4:351 NM_001099786 ICAM2

NM_001552 IGFBP4

1.5 2.5 1071 IL18:0 NM_020169 LXN

1.0 2.0 3.0 2882 LXN:301

0.5

NM_001562 IL18

1.0 2.0 3.0 1388 IL1B:156

0.0

2876 ICAM2:69 0.8 1.2 1.6 2878 IL1B:638 1.0 2.0 3.0 0.0 2880 IL18:626 0.5 1.0 1.5 2.0 2.5 2883 LXN:200 1.0 2.0 3.0 0.0

2874 IGFBP4:681 1.0 1.5 2.0 2877 ICAM2:787 0.4 0.8 1.2 0.5 1.0 1.5 2875 ICAM2:355 NM_000576 IL1B

1.5 2.0 2.5 3.0 2872 IGFBP4:351 NM_001099786 ICAM2

NM_001552 IGFBP4

1.5 2.5 1071 IL18:0 NM_020169 LXN

1.0 2.0 3.0 2882 LXN:301

0.5

NM_001562 IL18

1.0 2.0 3.0 1388 IL1B:156

0.0

0.0 2879 IL1B:765 1.0 2.0 3.0 0.0 2881 IL18:695 1.5 2.0 2.5 1.0 2884 LXN:252 1.0 2.0 3.0 0.0

1.4 1.8 2.2 2873 IGFBP4:759 NM_001099786 ICAM2

NM_001552 IGFBP4

1.0 2.0 3.0 2878 IL1B:638

0.0

1.0 2.0 3.0 2883 LXN:200

0.5 1.0 1.5 2.0 2.5 2880 IL18:626 NM_020169 LXN

NM_001562 IL18

0.0

0.8 1.2 1.6 2876 ICAM2:69 NM_000576 IL1B

1.0

2874 IGFBP4:681 1.0 1.5 2.0 2877 ICAM2:787 0.4 0.8 1.2 0.0 2879 IL1B:765 1.0 2.0 3.0 0.0 2881 IL18:695 1.5 2.0 2.5 1.0 2884 LXN:252 1.0 2.0 3.0 0.0

2886 LZTR1:844 100 200 300

0

2889 LSM12:416 400 800

0

2892 MRC2:492 0 50 150 250

2895 MSN:185 400 800

0

2898 MLH1:95 0 50 150 250

0

0

0

0

100 300 2897 MLH1:188

Slp = 0.54 Intcpt = 14

2000 4000 2894 MSN:409 NM_000249 MLH1

Slp = -0.15 Intcpt = 862

NM_002444 MSN

200 600 2891 MRC2:140

Slp = -0.01 Intcpt = 128

40 80 120 2888 LSM12:523 NM_006039 MRC2

Slp = -4.68 Intcpt = 592

0 100 300 500 2885 LZTR1:101 NM_152344 LSM12

Slp = 0.48 Intcpt = 111

NM_006767 LZTR1

2887 LZTR1:479 20 40 60 80 0

2890 LSM12:361 0 20 60 100

2893 MRC2:742 100 200 300 0

2896 MSN:649 200 400 600 0

2899 MLH1:238 50 100 200 0 0

0

0

0

100 300 2897 MLH1:188

Slp = 0.52 Intcpt = -14

2000 4000 2894 MSN:409 NM_000249 MLH1

Slp = -0.11 Intcpt = 506

NM_002444 MSN

200 600 2891 MRC2:140

Slp = -0.03 Intcpt = 208

40 80 120 2888 LSM12:523 NM_006039 MRC2

Slp = 0.87 Intcpt = 0

0 100 300 500 2885 LZTR1:101 NM_152344 LSM12

Slp = 0.19 Intcpt = 2

NM_006767 LZTR1 2887 LZTR1:479 20 40 60 80 0 2890 LSM12:361 0 20 60 100 2893 MRC2:742 100 200 300 0 2896 MSN:649 200 400 600 0 2899 MLH1:238 50 100 200 0

Slp = 0.57 Intcpt = 127

400 800 2889 LSM12:416 NM_006039 MRC2

Slp = -0.03 Intcpt = 58

100 200 300 2886 LZTR1:844 NM_152344 LSM12

Slp = 0.88 Intcpt = -16

400 800 2895 MSN:185 NM_000249 MLH1

0 50 150 250 2898 MLH1:95

0

Slp = 0.62 Intcpt = -63

NM_002444 MSN

0 50 150 250 2892 MRC2:492

0

0

Slp = 0.28 Intcpt = -22

NM_006767 LZTR1

2.0 2.4 2885 LZTR1:101 NM_152344 LSM12

NM_006767 LZTR1

1.9

NM_002444 MSN

2.0 2.4 2.8 2891 MRC2:140

2.1 2.3 2.5 2897 MLH1:188

3.1 3.3 3.5 2894 MSN:409 NM_000249 MLH1

1.6

1.5 1.7 1.9 2.1 2888 LSM12:523 NM_006039 MRC2

1.6

2886 LZTR1:844 2.0 2.2 2.4 2889 LSM12:416 2.2 2.6 3.0 2892 MRC2:492 2.1 2.3 1.9 2895 MSN:185 2.6 3.0 2.2 2898 MLH1:95 2.0 2.2 2.4 1.8

2887 LZTR1:479 1.4 1.8 2.0 2.4 2885 LZTR1:101 NM_152344 LSM12

NM_006767 LZTR1

1.9

NM_002444 MSN

2.0 2.4 2.8 2891 MRC2:140

2.1 2.3 2.5 2897 MLH1:188

3.1 3.3 3.5 2894 MSN:409 NM_000249 MLH1

1.6

1.5 1.7 1.9 2.1 2888 LSM12:523 NM_006039 MRC2

1.6

1.0 2890 LSM12:361 1.4 1.6 1.8 2.0 2893 MRC2:742 2.1 2.2 2.3 2.4 2.5

2896 MSN:649 2.2 2.6 1.8 2899 MLH1:238 1.6 1.8 2.0 2.2

2.2 2.4 2886 LZTR1:844 NM_152344 LSM12

NM_006767 LZTR1

1.8

2.0 2.2 2.4 2898 MLH1:95

2.6 3.0 2895 MSN:185 NM_000249 MLH1

NM_002444 MSN

2.1 2.3 2892 MRC2:492

2.2

1.9

2.2 2.6 3.0 2889 LSM12:416 NM_006039 MRC2

2.0

2887 LZTR1:479 1.4 1.8 1.0

2890 LSM12:361 1.4 1.6 1.8 2.0 2893 MRC2:742 2.1 2.2 2.3 2.4 2.5

2896 MSN:649 2.2 2.6 1.8 2899 MLH1:238 1.6 1.8 2.0 2.2

2901 MSH2:487 40 80 120

0

2904 MSH6:317 0 200 600 1000

2907 MYNN:311 20 40 60

0

2910 NSF:253 200 400

0

3012 CRKL:463 200 600

0

Slp = 1.04 Intcpt = -12

NM_006178 NSF

10 20 30 40 2906 MYNN:530

Slp = 1.35 Intcpt = 6

200 400 2903 MSH6:267 NM_018657 MYNN

0 100 300 3011 CRKL:608

Slp = 1.95 Intcpt = -22

0 100 300 500 2909 NSF:300 NM_005207 CRKL

0

0

Slp = 1.80 Intcpt = -16

0 50 150 250 2900 MSH2:415 NM_000179 MSH6

Slp = 0.40 Intcpt = 0

NM_000251 MSH2

2902 MSH2:75 0 200 600 100

2905 MSH6:184 400 800 0

2908 MYNN:122 0 50 150 250

2911 NSF:114 200 400 0

3013 CRKL:340 0 100 300

Slp = 0.97 Intcpt = 6

NM_006178 NSF

10 20 30 40 2906 MYNN:530

Slp = 3.22 Intcpt = 55

200 400 2903 MSH6:267 NM_018657 MYNN

0 100 300 3011 CRKL:608

Slp = 1.10 Intcpt = -17

0 100 300 500 2909 NSF:300 NM_005207 CRKL

0

0

Slp = 2.09 Intcpt = 34

0 50 150 250 2900 MSH2:415 NM_000179 MSH6

Slp = 3.73 Intcpt = 34

NM_000251 MSH2

2902 MSH2:75 0 200 600 100 2905 MSH6:184 400 800 0 2908 MYNN:122 0 50 150 250 2911 NSF:114 200 400 0 3013 CRKL:340 0 100 300

Slp = 1.14 Intcpt = 60

40 80 120 2901 MSH2:487 NM_000179 MSH6

0

0

0

200 600 3012 CRKL:463

Slp = 0.56 Intcpt = -5

200 400 2910 NSF:253 NM_005207 CRKL

Slp = 0.92 Intcpt = 20

NM_006178 NSF

20 40 60 2907 MYNN:311

Slp = 1.56 Intcpt = 61

0 200 600 1000 2904 MSH6:317 NM_018657 MYNN

0

Slp = 9.09 Intcpt = 36

NM_000251 MSH2

1.0 2.0 2900 MSH2:415 NM_000179 MSH6

NM_000251 MSH2

1.0

1.2

1.6 2.0 2.4 3011 CRKL:608

2.0 2.2 2.4 2.6 2909 NSF:300 NM_005207 CRKL

NM_006178 NSF

0.0

0.5 1.0 1.5 2906 MYNN:530

1.5 2.0 2.5 2903 MSH6:267 NM_018657 MYNN

0.0

2901 MSH2:487 1.0 1.5 2.0 2904 MSH6:317 1.5 2.0 2.5 3.0 2907 MYNN:311 0.8 1.2 1.6 2910 NSF:253 2.2 2.4 2.6 2.0 3012 CRKL:463 1.5 2.0 2.5

1.0 2.0 2900 MSH2:415 NM_000179 MSH6

NM_000251 MSH2

1.0

1.2

1.6 2.0 2.4 3011 CRKL:608

2.0 2.2 2.4 2.6 2909 NSF:300 NM_005207 CRKL

NM_006178 NSF

0.0

0.5 1.0 1.5 2906 MYNN:530

1.5 2.0 2.5 2903 MSH6:267 NM_018657 MYNN

0.0

2902 MSH2:75 1.0 1.5 2.0 2.5 3.0 2905 MSH6:184 2.0 2.5 3.0 1.5 2908 MYNN:122 1.6 2.0 2.4 2911 NSF:114 2.0 2.2 2.4 2.6 3013 CRKL:340 1.5 2.0 2.5

2902 MSH2:75 1.0 1.5 2.0 2.5 3.0 2905 MSH6:184 2.0 2.5 3.0 1.5 2908 MYNN:122 1.6 2.0 2.4

2.2 2.4 2.6 2910 NSF:253 NM_005207 CRKL

NM_006178 NSF

0.8 1.2 1.6 2907 MYNN:311

1.5 2.0 2.5 3.0 2904 MSH6:317 NM_018657 MYNN

1.0 1.5 2.0 2901 MSH2:487 NM_000179 MSH6

NM_000251 MSH2

1.5 2.0 2.5 3012 CRKL:463

2.0

2911 NSF:114 2.0 2.2 2.4 2.6 3013 CRKL:340 1.5 2.0 2.5

3015 ERBB2:271 100 200 300

0

3018 KRAS:246 500 1500

0

3021 MYC:474 500 1000 1500

0

3024 BRAF:139 20 40 60

0

3045 DYNLL1:320 400 800 1400

0

Slp = 0.35 Intcpt = 388

20 40 60 80 3023 BRAF:208 NM_003746 DYNLL1

Slp = 0.31 Intcpt = 31

NM_004333 BRAF

200 600 3020 MYC:376

Slp = 1.89 Intcpt = 3

400 800 3017 KRAS:430 NM_002467 MYC

Slp = 1.60 Intcpt = 11

200 600 3014 ERBB2:200 NM_004985 KRAS

0 500 1500 2500 3044 DYNLL1:204

0

0

0

0

Slp = 0.44 Intcpt = 3

NM_004448 ERBB2

3016 ERBB2:334 50 100 150

0

3019 KRAS:554 400 800 1400

0

3022 MYC:540 400 800 1200

0

3025 BRAF:315 0 50 150 250

3046 DYNLL1:257 200 400 600

0

Slp = 0.23 Intcpt = 125

20 40 60 80 3023 BRAF:208 NM_003746 DYNLL1

Slp = 2.66 Intcpt = -15

NM_004333 BRAF

200 600 3020 MYC:376

Slp = 1.63 Intcpt = -7

400 800 3017 KRAS:430 NM_002467 MYC

Slp = 1.23 Intcpt = -8

200 600 3014 ERBB2:200 NM_004985 KRAS

0 500 1500 2500 3044 DYNLL1:204

0

0

0

0

Slp = 0.18 Intcpt = 25

NM_004448 ERBB2 3016 ERBB2:334 50 100 150 0 3019 KRAS:554 400 800 1400 0 3022 MYC:540 400 800 1200 0 3025 BRAF:315 0 50 150 250 3046 DYNLL1:257 200 400 600 0 0

0

0

0

0

400 800 1400 3045 DYNLL1:320

Slp = 0.46 Intcpt = 66

20 40 60 3024 BRAF:139 NM_003746 DYNLL1

Slp = 1.96 Intcpt = -6

NM_004333 BRAF

500 1000 1500 3021 MYC:474

Slp = 0.86 Intcpt = -9

500 1500 3018 KRAS:246 NM_002467 MYC

Slp = 0.76 Intcpt = -16

100 200 300 3015 ERBB2:271 NM_004985 KRAS

Slp = 0.39 Intcpt = 25

NM_004448 ERBB2

2.2 2.6 3014 ERBB2:200 NM_004985 KRAS

NM_004448 ERBB2

1.8

3015 ERBB2:271 1.4 1.8 2.2 2.9 3.1 3.3 3044 DYNLL1:204

1.2 1.4 1.6 1.8 3023 BRAF:208 NM_003746 DYNLL1

NM_004333 BRAF

1.5 2.0 2.5 3020 MYC:376

1.0 1.5 2.0 2.5 3.0 3017 KRAS:430 NM_002467 MYC

3018 KRAS:246 1.5 2.0 2.5 3.0 3021 MYC:474 2.2 2.6 3.0 1.8 3024 BRAF:139 1.60 1.75 1.45 3045 DYNLL1:320 2.80 2.90 3.00 3.10

2.2 2.6 3014 ERBB2:200 NM_004985 KRAS

NM_004448 ERBB2

1.8

3016 ERBB2:334 1.6 1.8 2.0 2.2 2.9 3.1 3.3 3044 DYNLL1:204

1.2 1.4 1.6 1.8 3023 BRAF:208 NM_003746 DYNLL1

NM_004333 BRAF

1.5 2.0 2.5 3020 MYC:376

1.0 1.5 2.0 2.5 3.0 3017 KRAS:430 NM_002467 MYC

3019 KRAS:554 1.5 2.0 2.5 3.0 3022 MYC:540 2.0 2.5 3.0

3025 BRAF:315 1.6 2.0 2.4 3046 DYNLL1:257 2.50 2.60 2.70 2.80

1.8 2.2 3015 ERBB2:271 NM_004985 KRAS

NM_004448 ERBB2

2.2 2.6 3.0 3021 MYC:474

1.45

1.60 1.75 3024 BRAF:139 NM_003746 DYNLL1

NM_004333 BRAF

1.8

1.5 2.0 2.5 3.0 3018 KRAS:246 NM_002467 MYC

1.4

3016 ERBB2:334 1.6 1.8 2.0 2.2 3019 KRAS:554 1.5 2.0 2.5 3.0 3022 MYC:540 2.0 2.5 3.0 3025 BRAF:315 1.6 2.0 2.4

2.80 2.90 3.00 3.10 3045 DYNLL1:320

3046 DYNLL1:257 2.50 2.60 2.70 2.80

3052 ANAPC5:735 100 200 300

0

3060 ACTB:100 4000 8000

0

1444 PAI-1:304 1000 2500

0

2048 OAZ1:258 1000 2500

0

2617 TFF1:320 0 100 300

0

0

0

0

0

Slp = 1.52 Intcpt = 1291

1000 2000 3000 2616 TFF1:95

Slp = 0.16 Intcpt = 3

1000 2000 3000 2047 OAZ1:153 NM_003225 TFF1

Slp = 0.87 Intcpt = 302

NM_004152 OAZ1

4000 8000 1059 PAI-1:58

Slp = 0.26 Intcpt = -53

2000 4000 1027 ACTB:246 NM_000602 PAI-1

ACTB

1000 2500 3051 ANAPC5:107

Slp = 0.01 Intcpt = 143

NM_016237 ANAPC5

3053 ANAPC5:822 100 300

0

3061 ACTB:293 2000 4000 6000

0

2980 PAI-1:489 2000 5000

0

3050 OAZ1:48 400 800

0

2618 TFF1:283 1000 3000

0 0

0

0

0

0

Slp = 1.06 Intcpt = -50

1000 2000 3000 2616 TFF1:95

Slp = 1.23 Intcpt = 121

1000 2000 3000 2047 OAZ1:153 NM_003225 TFF1

Slp = 0.36 Intcpt = 106

NM_004152 OAZ1

4000 8000 1059 PAI-1:58

Slp = 0.65 Intcpt = -27

2000 4000 1027 ACTB:246 NM_000602 PAI-1

ACTB

1000 2500 3051 ANAPC5:107

Slp = -0.04 Intcpt = 318

NM_016237 ANAPC5 3053 ANAPC5:822 100 300 0 3061 ACTB:293 2000 4000 6000 0 2980 PAI-1:489 2000 5000 0 3050 OAZ1:48 400 800 0 2618 TFF1:283 1000 3000 0

Slp = 7.56 Intcpt = 96

1000 2500 2048 OAZ1:258 NM_003225 TFF1

Slp = 0.39 Intcpt = 25

NM_004152 OAZ1

1000 2500 1444 PAI-1:304

Slp = 2.40 Intcpt = 165

4000 8000 3060 ACTB:100 NM_000602 PAI-1

Slp = 0.63 Intcpt = -553

100 200 300 3052 ANAPC5:735 NM_001101 ACTB

0 100 300 2617 TFF1:320

0

0

0

0

Slp = 1.44 Intcpt = 26

NM_016237 ANAPC5 3052 ANAPC5:735 2.0 2.2 2.4 1.8 3060 ACTB:100 3.7 3.9 3.5 1444 PAI-1:304 2.0 3.0

NM_016237 ANAPC5

1.0

2.0 3.0 2616 TFF1:95

2.6 3.0 3.4 2047 OAZ1:153 NM_003225 TFF1

NM_004152 OAZ1

1.5 2.5 3.5 1059 PAI-1:58

3.0 3.2 3.4 3.6 1027 ACTB:246 NM_000602 PAI-1

ACTB

3.0 3.2 3.4 3051 ANAPC5:107

0.5

1.0 2048 OAZ1:258 2.8 3.0 3.2 3.4 2617 TFF1:320 0.5 1.0 1.5 2.0 2.5

3053 ANAPC5:822 2.0 2.2 2.4 2.6 3061 ACTB:293 3.0 3.2 3.4 3.6 3.8

NM_016237 ANAPC5

1.0

2.0 3.0 2616 TFF1:95

2.6 3.0 3.4 2047 OAZ1:153 NM_003225 TFF1

NM_004152 OAZ1

1.5 2.5 3.5 1059 PAI-1:58

3.0 3.2 3.4 3.6 1027 ACTB:246 NM_000602 PAI-1

ACTB

3.0 3.2 3.4 3051 ANAPC5:107

0.5

2980 PAI-1:489 1.5 2.5 3.5 3050 OAZ1:48 2.4 2.6 2.8 3.0 2618 TFF1:283 2.0 2.5 3.0 3.5

1.8

3053 ANAPC5:822 2.0 2.2 2.4 2.6

0.5 1.0 1.5 2.0 2.5 2617 TFF1:320

2.8 3.0 3.2 3.4 2048 OAZ1:258 NM_003225 TFF1

NM_004152 OAZ1

1.0

2.0 3.0 1444 PAI-1:304

3.7 3.9 3060 ACTB:100 NM_000602 PAI-1

2.0 2.2 2.4 3052 ANAPC5:735 NM_001101 ACTB

NM_016237 ANAPC5

3.5

3061 ACTB:293 3.0 3.2 3.4 3.6 3.8 2980 PAI-1:489 1.5 2.5 3.5 3050 OAZ1:48 2.4 2.6 2.8 3.0 2618 TFF1:283 2.0 2.5 3.0 3.5

2620 TFRC:78 200 400 600

0

2777 XIST:91 0 200 600

2780 TRAF4:249 5 10 20

0

2807 RGS4:271 500 1500

0

2810 SLC16A3:214 0 20 60 100

Slp = 0.12 Intcpt = 35

100 200 300 2806 RGS4:60 NM_001042422 SLC16A3

Slp = 6.86 Intcpt = 15

NM_001102445 RGS4

10 20 30 40 2779 TRAF4:175

Slp = 0.39 Intcpt = 0

200 400 600 2776 XIST:203 NM_004295 TRAF4

Slp = 1.51 Intcpt = -39

200 400 600 2619 TFRC:145 AK025198 XIST

0 100 300 500 2809 SLC16A3:57

0

0

0

0

Slp = 1.19 Intcpt = 22

NM_003234 TFRC

2621 TFRC:229 400 800 1200

0

2778 XIST:327 100 200 300

0

2781 TRAF4:343 10 20 30 40

0

2808 RGS4:185 0 50 150 250

2811 SLC16A3:343 0 50 150 250

Slp = 0.59 Intcpt = -10

100 200 300 2806 RGS4:60 NM_001042422 SLC16A3

Slp = 0.80 Intcpt = 16

NM_001102445 RGS4

10 20 30 40 2779 TRAF4:175

Slp = 0.43 Intcpt = 14

200 400 600 2776 XIST:203 NM_004295 TRAF4

Slp = 0.51 Intcpt = -2

200 400 600 2619 TFRC:145 AK025198 XIST

0 100 300 500 2809 SLC16A3:57

0

0

0

0

Slp = 1.97 Intcpt = -23

NM_003234 TFRC

2621 TFRC:229 400 800 1200 0 2778 XIST:327 100 200 300 0 2781 TRAF4:343 10 20 30 40 0 2808 RGS4:185 0 50 150 250 2811 SLC16A3:343 0 50 150 250

Slp = 0.32 Intcpt = 13

200 400 600 2620 TFRC:78 AK025198 XIST

Slp = 4.02 Intcpt = -131

500 1500 2807 RGS4:271 NM_001042422 SLC16A3

Slp = 0.12 Intcpt = 14

NM_001102445 RGS4

5 10 20 2780 TRAF4:249

0 20 60 100 2810 SLC16A3:214

0

0

Slp = 0.12 Intcpt = 25

0 200 600 2777 XIST:91 NM_004295 TRAF4

0

Slp = 1.65 Intcpt = -57

NM_003234 TFRC 2620 TFRC:78 2.2 2.6 1.8 3.0 2777 XIST:91 1.5 2.0 2.5

1.8 2.2 2.6 2619 TFRC:145 AK025198 XIST

NM_003234 TFRC

1.4 1.8 2.2 2.6 2809 SLC16A3:57

0.5 1.0 1.5 2.0 2.5 2806 RGS4:60 NM_001042422 SLC16A3

NM_001102445 RGS4

1.3 1.5 2779 TRAF4:175

1.6 2.0 2.4 2.8 2776 XIST:203 NM_004295 TRAF4

1.1

2780 TRAF4:249 0.6 0.8 1.0 1.2 1.4 2807 RGS4:271 1.0 2.0 3.0 2810 SLC16A3:214 1.5 1.7 1.9

2621 TFRC:229 2.0 2.4 2.8 2778 XIST:327 1.5 2.0 2.5 1.0

1.8 2.2 2.6 2619 TFRC:145 AK025198 XIST

NM_003234 TFRC

1.4 1.8 2.2 2.6 2809 SLC16A3:57

0.5 1.0 1.5 2.0 2.5 2806 RGS4:60 NM_001042422 SLC16A3

NM_001102445 RGS4

1.3 1.5 2779 TRAF4:175

1.6 2.0 2.4 2.8 2776 XIST:203 NM_004295 TRAF4

1.1

2781 TRAF4:343 1.3 1.4 1.5 1.6 2808 RGS4:185 1.2 1.6 2.0 2.4 2811 SLC16A3:343 1.0 1.5 2.0 2.5

2621 TFRC:229 2.0 2.4 2.8 2778 XIST:327 1.5 2.0 2.5 1.0

1.5 2.0 2.5 2777 XIST:91 NM_004295 TRAF4

2.2 2.6 2620 TFRC:78 AK025198 XIST

1.8

NM_003234 TFRC

3.0

1.5 1.7 1.9 2810 SLC16A3:214

1.0 2.0 3.0 2807 RGS4:271 NM_001042422 SLC16A3

NM_001102445 RGS4

0.6 0.8 1.0 1.2 1.4 2780 TRAF4:249

2781 TRAF4:343 1.3 1.4 1.5 1.6 2808 RGS4:185 1.2 1.6 2.0 2.4 2811 SLC16A3:343 1.0 1.5 2.0 2.5

2913 NUP85:147 100 200 300

0

2916 OSBPL11:319 0 40 80 120

2919 PI4KA:421 200 400 600

0

2922 PGAM1:175 0 500 1500 2500

2925 PAFAH1B1:333 0 50 100

Slp = 0.40 Intcpt = -8

100 200 300 2912 NUP85:95 NM_022776 OSBPL11

Slp = 0.53 Intcpt = 30

1000 2000 3000 2921 PGAM1:123 NM_000430 PAFAH1B1

0 50 100 200 2924 PAFAH1B1:210

0

Slp = 0.81 Intcpt = -67

NM_002629 PGAM1

0 500 1500 2918 PI4KA:145

Slp = 0.33 Intcpt = -11

0 100 200 300 2915 OSBPL11:235 NM_002650 PI4KA

0

Slp = 1.07 Intcpt = 0

NM_024844 NUP85

2914 NUP85:207 0 5 15 25 35

2917 OSBPL11:122 0 50 150 250

2920 PI4KA:470 200 400 600 0

2923 PGAM1:305 500 1000 0

2926 PAFAH1B1:130 0 200 400 600

Slp = 0.86 Intcpt = -15

100 200 300 2912 NUP85:95 NM_022776 OSBPL11

Slp = 3.39 Intcpt = -8

1000 2000 3000 2921 PGAM1:123 NM_000430 PAFAH1B1

0 50 100 200 2924 PAFAH1B1:210

0

Slp = 0.55 Intcpt = -41

NM_002629 PGAM1

0 500 1500 2918 PI4KA:145

Slp = 0.28 Intcpt = 0

0 100 200 300 2915 OSBPL11:235 NM_002650 PI4KA

0

Slp = 0.10 Intcpt = 1

NM_024844 NUP85

2914 NUP85:207 0 5 15 25 35 2917 OSBPL11:122 0 50 150 250 2920 PI4KA:470 200 400 600 0 2923 PGAM1:305 500 1000 0 2926 PAFAH1B1:130 0 200 400 600

Slp = 2.07 Intcpt = 4

100 200 300 2913 NUP85:147 NM_022776 OSBPL11

Slp = 0.67 Intcpt = 14

NM_002629 PGAM1

200 400 600 2919 PI4KA:421

0 50 100 2925 PAFAH1B1:333

Slp = 4.92 Intcpt = -49

0 500 1500 2500 2922 PGAM1:175 NM_000430 PAFAH1B1

0

Slp = 0.85 Intcpt = 9

0 40 80 120 2916 OSBPL11:319 NM_002650 PI4KA

0

Slp = 0.09 Intcpt = 1

NM_024844 NUP85

2913 NUP85:147 1.9 2.1 2.3 2.5 1.4 1.8 2.2 2924 PAFAH1B1:210

2.6 3.0 3.4 2921 PGAM1:123 NM_000430 PAFAH1B1

NM_002629 PGAM1

1.4 1.8 2.2 2924 PAFAH1B1:210

2.6 3.0 3.4 2921 PGAM1:123 NM_000430 PAFAH1B1

NM_002629 PGAM1

1.4 1.6 1.8 2.0 2925 PAFAH1B1:333

2.6 3.0 3.4 2922 PGAM1:175 NM_000430 PAFAH1B1

NM_002629 PGAM1

1.5 2.0 2.5 2919 PI4KA:421

2.0 2.5 3.0 2918 PI4KA:145

2.0 2.5 3.0 2918 PI4KA:145

1.9 2.1 2.3 2.5 2913 NUP85:147 NM_022776 OSBPL11

NM_024844 NUP85

0.8 1.2 1.6 2.0 2916 OSBPL11:319 NM_002650 PI4KA

1.9 2.1 2.3 2.5 2912 NUP85:95 NM_022776 OSBPL11

NM_024844 NUP85

1.4 1.8 2.2 2915 OSBPL11:235 NM_002650 PI4KA

1.9 2.1 2.3 2.5 2912 NUP85:95 NM_022776 OSBPL11

NM_024844 NUP85

1.4 1.8 2.2 2915 OSBPL11:235 NM_002650 PI4KA

2916 OSBPL11:319 0.8 1.2 1.6 2.0 2922 PGAM1:175 2.6 3.0 3.4 2925 PAFAH1B1:333 1.4 1.6 1.8 2.0

2920 PI4KA:470 0.5 1.5 2.5

2923 PGAM1:305 2.4 2.8 3.2 2926 PAFAH1B1:130 2.0 2.2 2.4 2.6 2.8

2919 PI4KA:421 1.5 2.0 2.5

2914 NUP85:207 1.1 1.3 1.5 0.9 2917 OSBPL11:122 1.0 1.4 1.8 2.2

2914 NUP85:207 1.1 1.3 1.5 0.9 2917 OSBPL11:122 1.0 1.4 1.8 2.2

2920 PI4KA:470 0.5 1.5 2.5

2923 PGAM1:305 2.4 2.8 3.2 2926 PAFAH1B1:130 2.0 2.2 2.4 2.6 2.8

2928 PDPN:78 50 150

0

2931 PTRF:288 0 10 30 50

2934 PCOLCE2:145 0 50 150

2937 PLOD2:380 500 1000

0

2940 P4HB:511 0 500 1500 2500

Slp = 0.01 Intcpt = 5

20 40 60 2927 PDPN:279 NM_012232 PTRF

0

0

2000 4000 6000 2939 P4HB:106

Slp = 0.38 Intcpt = -42

500 1500 2936 PLOD2:567 NM_000918 P4HB

Slp = 0.78 Intcpt = 7

NM_182943 PLOD2

0 40 80 120 2933 PCOLCE2:285

Slp = 1.52 Intcpt = 6

0 1000 3000 2930 PTRF:216 NM_013363 PCOLCE2

0

Slp = 2.51 Intcpt = -50

NM_006474 PDPN

2929 PDPN:716 10 20 30 40

0

2932 PTRF:584 100 200 300

0

2935 PCOLCE2:195 0 40 80 120

2938 PLOD2:95 400 800 1200

0

2941 P4HB:901 400 800

0

Slp = 0.04 Intcpt = 48

20 40 60 2927 PDPN:279 NM_012232 PTRF

0

0

2000 4000 6000 2939 P4HB:106

Slp = 0.14 Intcpt = -11

500 1500 2936 PLOD2:567 NM_000918 P4HB

Slp = 0.53 Intcpt = 0

NM_182943 PLOD2

0 40 80 120 2933 PCOLCE2:285

Slp = 0.92 Intcpt = 0

0 1000 3000 2930 PTRF:216 NM_013363 PCOLCE2

0

Slp = 0.49 Intcpt = -4

NM_006474 PDPN 2929 PDPN:716 10 20 30 40 0 2932 PTRF:584 100 200 300 0 2935 PCOLCE2:195 0 40 80 120 2938 PLOD2:95 400 800 1200 0 2941 P4HB:901 400 800 0

Slp = 6.63 Intcpt = -22

50 150 2928 PDPN:78 NM_012232 PTRF

Slp = 0.37 Intcpt = 17

500 1000 2937 PLOD2:380 NM_000918 P4HB

0 500 1500 2500 2940 P4HB:511

0

Slp = 0.69 Intcpt = -7

NM_182943 PLOD2

0 50 150 2934 PCOLCE2:145

Slp = 0.61 Intcpt = -4

0 10 30 50 2931 PTRF:288 NM_013363 PCOLCE2

0

Slp = 0.20 Intcpt = 5

NM_006474 PDPN 2928 PDPN:78 1.0 1.5 2.0 2931 PTRF:288 1.3 1.5 1.7 3.2 3.4 3.6 2930 PTRF:216 NM_013363 PCOLCE2

1.5 1.6 1.7 1.8 2927 PDPN:279 NM_012232 PTRF

NM_006474 PDPN

3.0

1.1 3.0 3.2 3.4 3.6 3.8 2939 P4HB:106

2.0 2.4 2.8 3.2 2936 PLOD2:567 NM_000918 P4HB

NM_182943 PLOD2

0.0 0.5 1.0 1.5 2.0 2933 PCOLCE2:285

2934 PCOLCE2:145 1.0 1.5 2.0 2937 PLOD2:380 2.2 2.6 3.0 1.8 2940 P4HB:511 2.8 3.2 2.4

2929 PDPN:716 0.8 1.0 1.2 1.4 1.6 3.2 3.4 3.6 2930 PTRF:216 NM_013363 PCOLCE2

1.5 1.6 1.7 1.8 2927 PDPN:279 NM_012232 PTRF

NM_006474 PDPN

3.0

2932 PTRF:584 1.8 2.0 2.2 2.4

3.0 3.2 3.4 3.6 3.8 2939 P4HB:106

2.0 2.4 2.8 3.2 2936 PLOD2:567 NM_000918 P4HB

NM_182943 PLOD2

0.0 0.5 1.0 1.5 2.0 2933 PCOLCE2:285

2935 PCOLCE2:195 0.0 0.5 1.0 1.5 2.0

2938 PLOD2:95 2.0 2.5 3.0 1.5 2941 P4HB:901 2.4 2.8 2.0

2929 PDPN:716 0.8 1.0 1.2 1.4 1.6

1.3 1.5 1.7 2931 PTRF:288 NM_013363 PCOLCE2

1.0 1.5 2.0 2928 PDPN:78 NM_012232 PTRF

NM_006474 PDPN

1.8

2.4

2.8 3.2 2940 P4HB:511

2.2 2.6 3.0 2937 PLOD2:380 NM_000918 P4HB

NM_182943 PLOD2

1.0 1.5 2.0 2934 PCOLCE2:145

1.1

2932 PTRF:584 1.8 2.0 2.2 2.4 2935 PCOLCE2:195 0.0 0.5 1.0 1.5 2.0 2938 PLOD2:95 2.0 2.5 3.0 1.5 2941 P4HB:901 2.4 2.8 2.0

2943 PFN2:239 0 500 1500

2946 PTGIS:180 1000 2000 3000

0

2949 PSMD3:657 5 10 15 20 25

0

2952 PLP2:378 200 600

0

2955 RAB5C:595 200 600

0

Slp = 4.82 Intcpt = 380

NM_002668 PLP2

20 40 60 2948 PSMD3:443

Slp = 0.37 Intcpt = 0

2000 4000 2945 PTGIS:49 NM_002809 PSMD3

Slp = 0.47 Intcpt = -66

400 800 1200 2942 PFN2:133 NM_000961 PTGIS

0

500 1000 2954 RAB5C:78

Slp = -0.21 Intcpt = 703

0 10 30 50 2951 PLP2:155 NM_201434 RAB5C

0

0

0

Slp = 1.85 Intcpt = 38

NM_053024 PFN2

2944 PFN2:295 500 1500

0

2947 PTGIS:127 2000 4000

0

2950 PSMD3:113 400 800

0

2953 PLP2:714 0 100 300

2956 RAB5C:668 50 100 150

0

Slp = 8.97 Intcpt = 6

NM_002668 PLP2

20 40 60 2948 PSMD3:443

Slp = 15.42 Intcpt = 52

2000 4000 2945 PTGIS:49 NM_002809 PSMD3

Slp = 1.08 Intcpt = -33

400 800 1200 2942 PFN2:133 NM_000961 PTGIS

0

500 1000 2954 RAB5C:78

Slp = 0.14 Intcpt = -54

0 10 30 50 2951 PLP2:155 NM_201434 RAB5C

0

0

0

Slp = 1.67 Intcpt = 23

NM_053024 PFN2 2944 PFN2:295 500 1500 0 2947 PTGIS:127 2000 4000 0 2950 PSMD3:113 400 800 0 2953 PLP2:714 0 100 300 2956 RAB5C:668 50 100 150 0 0

0

0

0

200 600 2955 RAB5C:595

Slp = -0.20 Intcpt = 191

200 600 2952 PLP2:378 NM_201434 RAB5C

Slp = -0.06 Intcpt = 268

NM_002668 PLP2

5 10 15 20 25 2949 PSMD3:657

Slp = 39.79 Intcpt = 42

1000 2000 3000 2946 PTGIS:180 NM_002809 PSMD3

Slp = 2.17 Intcpt = 195

0 500 1500 2943 PFN2:239 NM_000961 PTGIS

Slp = 0.92 Intcpt = -23

NM_053024 PFN2 2943 PFN2:239 2.8 3.2 2.4 2946 PTGIS:180 1.0 2.0 3.0 2949 PSMD3:657 0.9 1.1 1.3 2.8 2.9 3.0 3.1 3.2 2954 RAB5C:78

0.5 1.0 1.5 2951 PLP2:155 NM_201434 RAB5C

NM_002668 PLP2

1.3 1.5 1.7 2948 PSMD3:443

1.5 2.5 3.5 2945 PTGIS:49 NM_002809 PSMD3

2.2 2.6 3.0 2942 PFN2:133 NM_000961 PTGIS

NM_053024 PFN2

0.0

2952 PLP2:378 2.5 2.6 2.7 2.8 2.9 2955 RAB5C:595 2.5 2.6 2.7 2.8 2.9

2944 PFN2:295 2.4 2.8 3.2 2947 PTGIS:127 1.5 2.5 3.5 2950 PSMD3:113 2.5 2.7 2.9

0.5 1.0 1.5 2951 PLP2:155 NM_201434 RAB5C

NM_002668 PLP2

1.3 1.5 1.7 2948 PSMD3:443

1.5 2.5 3.5 2945 PTGIS:49 NM_002809 PSMD3

2.2 2.6 3.0 2942 PFN2:133 NM_000961 PTGIS

NM_053024 PFN2

0.0

2953 PLP2:714 2.0 2.2 2.4 2.6

2.8 2.9 3.0 3.1 3.2 2954 RAB5C:78

2956 RAB5C:668 1.6 1.8 2.0 2.2

2.8 3.2 2943 PFN2:239 NM_000961 PTGIS

NM_053024 PFN2

2.5 2.6 2.7 2.8 2.9 2955 RAB5C:595

2.5 2.6 2.7 2.8 2.9 2952 PLP2:378 NM_201434 RAB5C

NM_002668 PLP2

0.9 1.1 1.3 2949 PSMD3:657

1.0 2.0 3.0 2946 PTGIS:180 NM_002809 PSMD3

2.4

2944 PFN2:295 2.4 2.8 3.2 2947 PTGIS:127 1.5 2.5 3.5 2950 PSMD3:113 2.5 2.7 2.9 2953 PLP2:714 2.0 2.2 2.4 2.6 2956 RAB5C:668 1.6 1.8 2.0 2.2

2958 RGS1:606 20 40 60 80

0

2961 RB1:182 0 100 300

2964 RPL24:84 2000 5000

0

2967 RNF7:497 5 10 15 20

0

2969 SPARC:129 2000 4000

0

Slp = 0.47 Intcpt = 2

NM_014245 RNF7

2000 4000 2963 RPL24:259

Slp = 1.41 Intcpt = 393

200 600 2960 RB1:235 NM_000986 RPL24

0

500 1500 1453 SPARC:181

Slp = 2.64 Intcpt = -512

0 5 15 25 2966 RNF7:661 NM_003118 SPARC

0

0

Slp = 0.56 Intcpt = 1

0 50 150 250 2957 RGS1:205 NM_000321 RB1

Slp = -0.03 Intcpt = 40

NM_002922 RGS1

2959 RGS1:384 50 100 150

0

2962 RB1:294 100 200 300

0

2965 RPL24:343 500 1000 1500

0

2968 RNF7:85 20 40 60 80

0

2970 SPARC:306 1000 2500

0

Slp = 2.18 Intcpt = 14

NM_014245 RNF7

2000 4000 2963 RPL24:259

Slp = 0.31 Intcpt = 33

200 600 2960 RB1:235 NM_000986 RPL24

0

500 1500 1453 SPARC:181

Slp = 1.75 Intcpt = -333

0 5 15 25 2966 RNF7:661 NM_003118 SPARC

0

0

Slp = 0.43 Intcpt = 8

0 50 150 250 2957 RGS1:205 NM_000321 RB1

Slp = 0.53 Intcpt = 0

NM_002922 RGS1 2959 RGS1:384 50 100 150 0 2962 RB1:294 100 200 300 0 2965 RPL24:343 500 1000 1500 0 2968 RNF7:85 20 40 60 80 0 2970 SPARC:306 1000 2500 0

Slp = 0.74 Intcpt = 10

20 40 60 80 2958 RGS1:606 NM_000321 RB1

0

0

0

2000 4000 2969 SPARC:129

Slp = 0.68 Intcpt = -25

5 10 15 20 2967 RNF7:497 NM_003118 SPARC

Slp = 2.89 Intcpt = 23

NM_014245 RNF7

2000 5000 2964 RPL24:84

Slp = 0.21 Intcpt = -35

0 100 300 2961 RB1:182 NM_000986 RPL24

0

Slp = -0.99 Intcpt = 93

NM_002922 RGS1 2958 RGS1:606 1.4 1.6 1.8 1.2 2961 RB1:182 1.8 2.2 2.6 1.4 2.2 2.6 3.0 1453 SPARC:181

1.1 1.3 1.5 2966 RNF7:661 NM_003118 SPARC

NM_014245 RNF7

3.2 3.6 2963 RPL24:259

1.8 2.2 2.6 2960 RB1:235 NM_000986 RPL24

0.5 1.0 1.5 2.0 2.5 2957 RGS1:205 NM_000321 RB1

NM_002922 RGS1

2.8

2964 RPL24:84 3.0 3.2 3.4 3.6 3.8 2967 RNF7:497 0.4 0.8 1.2 0.0 2969 SPARC:129 1.5 2.0 2.5 3.0 3.5

2959 RGS1:384 0.5 1.0 1.5 2.0 2962 RB1:294 1.8 2.2 1.4 2.2 2.6 3.0 1453 SPARC:181

1.1 1.3 1.5 2966 RNF7:661 NM_003118 SPARC

NM_014245 RNF7

3.2 3.6 2963 RPL24:259

1.8 2.2 2.6 2960 RB1:235 NM_000986 RPL24

0.5 1.0 1.5 2.0 2.5 2957 RGS1:205 NM_000321 RB1

NM_002922 RGS1

2.8

2965 RPL24:343 2.4 2.8 3.2 2968 RNF7:85 1.6 1.7 1.8 1.9 2.0 2970 SPARC:306 1.0 2.0 3.0

1.4 1.6 1.8 2958 RGS1:606 NM_000321 RB1

NM_002922 RGS1

0.0

0.4 0.8 1.2 2967 RNF7:497 NM_003118 SPARC

NM_014245 RNF7

3.0 3.2 3.4 3.6 3.8 2964 RPL24:84

1.4

1.8 2.2 2.6 2961 RB1:182 NM_000986 RPL24

1.2

2959 RGS1:384 0.5 1.0 1.5 2.0 2962 RB1:294 1.8 2.2 1.4 2965 RPL24:343 2.4 2.8 3.2 2968 RNF7:85 1.6 1.7 1.8 1.9 2.0

1.5 2.0 2.5 3.0 3.5 2969 SPARC:129

2970 SPARC:306 1.0 2.0 3.0

2972 SELT:226 0 100 300 500

2975 SEPT9:149 200 400 600

0

2978 SERPIND1:157 0 500 1000

2982 STAT1:428 200 400

0

2985 SNX4:335 200 400 600

0

0

0

0

0

200 400 600 2984 SNX4:256

Slp = 1.09 Intcpt = -3

100 200 300 2981 STAT1:501 NM_003794 SNX4

Slp = 1.76 Intcpt = -32

NM_139266 STAT1

1000 3000 2977 SERPIND1:72

Slp = 0.48 Intcpt = -35

200 400 2974 SEPT9:201 NM_000185 SERPIND1

Slp = 1.32 Intcpt = 19

0 100 300 500 2971 SELT:81 NM_001113491 SEPT9

Slp = 1.00 Intcpt = -12

NM_016275 SELT

2973 SELT:333 100 200 300

0

2976 SEPT9:347 100 300

0

2979 SERPIND1:294 0 400 800

2983 STAT1:327 50 150

0

2986 SNX4:115 200 400 600

0 0

0

0

0

200 400 600 2984 SNX4:256

Slp = 1.07 Intcpt = -19

100 200 300 2981 STAT1:501 NM_003794 SNX4

Slp = 0.76 Intcpt = -12

NM_139266 STAT1

1000 3000 2977 SERPIND1:72

Slp = 0.29 Intcpt = -20

200 400 2974 SEPT9:201 NM_000185 SERPIND1

Slp = 0.53 Intcpt = 56

0 100 300 500 2971 SELT:81 NM_001113491 SEPT9

Slp = 0.65 Intcpt = -14

NM_016275 SELT

2973 SELT:333 100 200 300 0 2976 SEPT9:347 100 300 0 2979 SERPIND1:294 0 400 800 2983 STAT1:327 50 150 0 2986 SNX4:115 200 400 600 0

Slp = 0.61 Intcpt = 0

200 400 600 2975 SEPT9:149 NM_000185 SERPIND1

0

0

200 400 600 2985 SNX4:335

Slp = 0.95 Intcpt = -5

200 400 2982 STAT1:428 NM_003794 SNX4

Slp = 0.44 Intcpt = 0

NM_139266 STAT1

0 500 1000 2978 SERPIND1:157

0

Slp = 0.39 Intcpt = 54

0 100 300 500 2972 SELT:226 NM_001113491 SEPT9

Slp = 0.66 Intcpt = -7

NM_016275 SELT 2972 SELT:226 1.8 2.2 2.6 1.8 2.2 2.6 2971 SELT:81 NM_001113491 SEPT9

NM_016275 SELT

1.6

2.0 2.4 2.8 2984 SNX4:256

1.6 2.0 2.4 2981 STAT1:501 NM_003794 SNX4

NM_139266 STAT1

2.0 2.5 3.0 3.5 2977 SERPIND1:72

2.1

2.3 2.5 2.7 2974 SEPT9:201 NM_000185 SERPIND1

1.4

1.4 2975 SEPT9:149 2.4 2.6 2.8 2.2 2978 SERPIND1:157 0.5 1.5 2.5 2982 STAT1:428 1.8 2.2 2.6 2985 SNX4:335 1.6 2.0 2.4 2.8

2973 SELT:333 1.6 2.0 2.4 1.8 2.2 2.6 2971 SELT:81 NM_001113491 SEPT9

NM_016275 SELT

1.6

2.0 2.4 2.8 2984 SNX4:256

1.6 2.0 2.4 2981 STAT1:501 NM_003794 SNX4

NM_139266 STAT1

2.0 2.5 3.0 3.5 2977 SERPIND1:72

2.1

2.3 2.5 2.7 2974 SEPT9:201 NM_000185 SERPIND1

1.4

1.2 2976 SEPT9:347 2.0 2.2 2.4 2.6 1.8

2979 SERPIND1:294 0.5 1.5 2.5 2983 STAT1:327 1.4 1.8 2.2 2986 SNX4:115 1.8 2.2 2.6 1.4

2973 SELT:333 1.6 2.0 2.4 1.2

1.6 2.0 2.4 2.8 2985 SNX4:335

1.8 2.2 2.6 2982 STAT1:428 NM_003794 SNX4

NM_139266 STAT1

0.5 1.5 2.5 2978 SERPIND1:157

2.4 2.6 2.8 2975 SEPT9:149 NM_000185 SERPIND1

1.8 2.2 2.6 2972 SELT:226 NM_001113491 SEPT9

NM_016275 SELT

1.4

2.2

2976 SEPT9:347 2.0 2.2 2.4 2.6 1.8

2979 SERPIND1:294 0.5 1.5 2.5 2983 STAT1:327 1.4 1.8 2.2 2986 SNX4:115 1.8 2.2 2.6 1.4

2988 SPON1:303 500 1000

0

2991 THBS2:189 1000 3000

0

2994 TIMM22:470 0 5 10 20 30

2997 TOMM70A:109 0 100 300 500

3000 TMEM158:375 0 1000 2500

Slp = 1.59 Intcpt = 22

200 400 600 2987 SPON1:83 NM_003247 THBS2

Slp = 0.95 Intcpt = 4

NM_014820 TOMM70A

50 150 2993 TIMM22:632

0 1000 3000 2999 TMEM158:171

Slp = 0.73 Intcpt = -2

0 200 400 2996 TOMM70A:175 NM_015444 TMEM158

0

Slp = 0.04 Intcpt = 12

0 500 1500 2500 2990 THBS2:272 NM_013337 TIMM22

0

Slp = 2.25 Intcpt = -13

NM_006108 SPON1

2989 SPON1:164 0 100 300 50

2992 THBS2:132 0 500 1500 2500

2995 TIMM22:77 0 10 30 50

2998 TOMM70A:260 0 4000 10000

3001 TMEM158:266 0 1000 3000

Slp = 1.01 Intcpt = 2

200 400 600 2987 SPON1:83 NM_003247 THBS2

Slp = 6.37 Intcpt = 5915

NM_014820 TOMM70A

50 150 2993 TIMM22:632

0 1000 3000 2999 TMEM158:171

Slp = 1.09 Intcpt = 117

0 200 400 2996 TOMM70A:175 NM_015444 TMEM158

0

Slp = 0.14 Intcpt = 16

0 500 1500 2500 2990 THBS2:272 NM_013337 TIMM22

0

Slp = 0.64 Intcpt = 26

NM_006108 SPON1

2989 SPON1:164 0 100 300 50 2992 THBS2:132 0 500 1500 2500 2995 TIMM22:77 0 10 30 50 2998 TOMM70A:260 0 4000 10000 3001 TMEM158:266 0 1000 3000

Slp = 0.11 Intcpt = 29

1000 3000 2991 THBS2:189 NM_013337 TIMM22

Slp = 0.63 Intcpt = -7

500 1000 2988 SPON1:303 NM_003247 THBS2

0 1000 2500 3000 TMEM158:375

Slp = 1.46 Intcpt = 139

0 100 300 500 2997 TOMM70A:109 NM_015444 TMEM158

Slp = 4.96 Intcpt = 6240

NM_014820 TOMM70A

0 5 10 20 30 2994 TIMM22:470

0

0

Slp = 0.28 Intcpt = 30

NM_006108 SPON1 2988 SPON1:303 1.0 2.0 3.0 2.0 2.5 3.0 2990 THBS2:272 NM_013337 TIMM22

1.0 2.0 2987 SPON1:83 NM_003247 THBS2

NM_006108 SPON1

1.0 2.0 3.0 2999 TMEM158:171

1.4 1.8 2.2 2.6 2996 TOMM70A:175 NM_015444 TMEM158

NM_014820 TOMM70A

1.8 2.0 2.2 2993 TIMM22:632

1.5

2991 THBS2:189 0.5 1.5 2.5 3.5 2994 TIMM22:470 1.1 1.2 1.3 1.4 2997 TOMM70A:109 1.4 1.8 2.2 2.6 3000 TMEM158:375 0.5 1.5 2.5 3.5

2989 SPON1:164 1.4 1.8 2.2 2.6 2.0 2.5 3.0 2990 THBS2:272 NM_013337 TIMM22

1.0 2.0 2987 SPON1:83 NM_003247 THBS2

NM_006108 SPON1

1.0 2.0 3.0 2999 TMEM158:171

1.4 1.8 2.2 2.6 2996 TOMM70A:175 NM_015444 TMEM158

NM_014820 TOMM70A

1.8 2.0 2.2 2993 TIMM22:632

1.5

2992 THBS2:132 0.5 1.5 2.5 3.5 2995 TIMM22:77 1.4 1.6 1.2 2998 TOMM70A:260 3.6 3.8 4.0 3001 TMEM158:266 1.0 2.0 3.0

2989 SPON1:164 1.4 1.8 2.2 2.6

1.0 2.0 3.0 2988 SPON1:303 NM_003247 THBS2

NM_006108 SPON1

0.5 1.5 2.5 3.5 3000 TMEM158:375

1.4 1.8 2.2 2.6 2997 TOMM70A:109 NM_015444 TMEM158

NM_014820 TOMM70A

1.1 1.2 1.3 1.4 2994 TIMM22:470

0.5 1.5 2.5 3.5 2991 THBS2:189 NM_013337 TIMM22

2992 THBS2:132 0.5 1.5 2.5 3.5 2995 TIMM22:77 1.4 1.6

1.2 2998 TOMM70A:260 3.6 3.8 4.0 3001 TMEM158:266 1.0 2.0 3.0

3003 TMEM97:582 50 150

0

3006 TP53:95 4000 8000

0

3009 SR140:334 0 20 40 60 80

3027 VAT1:420 100 300

0

3030 VGLL3:506 0 20 60 100

Slp = 0.15 Intcpt = 18

20 40 60 80 3005 TP53:48 NM_001080415 SR140

Slp = 56.72 Intcpt = 2414

100 300 3002 TMEM97:652 NM_000546 TP53

0

0

50 150 3029 VGLL3:112

Slp = 0.41 Intcpt = 23

500 1500 3026 VAT1:114 NM_016206 VGLL3

Slp = 0.22 Intcpt = 10

NM_006373 VAT1

0 100 300 3008 SR140:105

0

0

Slp = 0.46 Intcpt = 40

NM_014573 TMEM97

3004 TMEM97:807 50 100 150

0

3007 TP53:142 100 300

0

3010 SR140:170 10 20 30 40

0

3028 VAT1:335 0 20 40 60 80

3031 VGLL3:175 50 100 200

0

Slp = -0.05 Intcpt = 32

20 40 60 80 3005 TP53:48 NM_001080415 SR140

Slp = 1.09 Intcpt = 149

100 300 3002 TMEM97:652 NM_000546 TP53

0

0

50 150 3029 VGLL3:112

Slp = 0.94 Intcpt = 6

500 1500 3026 VAT1:114 NM_016206 VGLL3

Slp = 0.05 Intcpt = 4

NM_006373 VAT1

0 100 300 3008 SR140:105

0

0

Slp = 0.38 Intcpt = -7

NM_014573 TMEM97

3004 TMEM97:807 50 100 150 0 3007 TP53:142 100 300 0 3010 SR140:170 10 20 30 40 0 3028 VAT1:335 0 20 40 60 80 3031 VGLL3:175 50 100 200 0

Slp = -0.02 Intcpt = 27

4000 8000 3006 TP53:95 NM_001080415 SR140

Slp = 0.02 Intcpt = 80

50 150 3003 TMEM97:582 NM_000546 TP53

Slp = 2.09 Intcpt = -35

100 300 3027 VAT1:420 NM_016206 VGLL3

0 20 60 100 3030 VGLL3:506

0

Slp = 0.24 Intcpt = 2

NM_006373 VAT1

0 20 40 60 80 3009 SR140:334

0

0

Slp = 0.73 Intcpt = -32

NM_014573 TMEM97

3003 TMEM97:582 1.6 2.0 2.4 NM_014573 TMEM97

0.0

1.0 2.0 3029 VGLL3:112

2.4 2.8 3.2 3026 VAT1:114 NM_016206 VGLL3

NM_006373 VAT1

1.8 2.2 2.6 3008 SR140:105

1.6 1.8 3005 TP53:48 NM_001080415 SR140

1.4 1.8 2.2 2.6 3002 TMEM97:652 NM_000546 TP53

1.4

3006 TP53:95 3.6 3.7 3.8 3.9 3009 SR140:334 0.5 1.0 1.5 2.0 3027 VAT1:420 2.0 2.4 1.6 3030 VGLL3:506 1.2 1.4 1.6 1.8 2.0

3004 TMEM97:807 0.8 1.2 1.6 2.0 3007 TP53:142 2.0 2.4

NM_014573 TMEM97

0.0

1.0 2.0 3029 VGLL3:112

2.4 2.8 3.2 3026 VAT1:114 NM_016206 VGLL3

NM_006373 VAT1

1.8 2.2 2.6 3008 SR140:105

1.6 1.8 3005 TP53:48 NM_001080415 SR140

1.4 1.8 2.2 2.6 3002 TMEM97:652 NM_000546 TP53

1.4

1.6 3010 SR140:170 1.1 1.3 1.5 3028 VAT1:335 1.2 1.6 2.0 3031 VGLL3:175 1.0 2.0 0.0

3004 TMEM97:807 0.8 1.2 1.6 2.0 3007 TP53:142 2.0 2.4 1.6 3010 SR140:170 1.1 1.3 1.5

NM_014573 TMEM97

1.2 1.4 1.6 1.8 2.0 3030 VGLL3:506

2.0 2.4 3027 VAT1:420 NM_016206 VGLL3

NM_006373 VAT1

0.5 1.0 1.5 2.0 3009 SR140:334

3.6 3.7 3.8 3.9 3006 TP53:95 NM_001080415 SR140

1.6 2.0 2.4 3003 TMEM97:582 NM_000546 TP53

1.6

3028 VAT1:335 1.2 1.6 2.0 3031 VGLL3:175 1.0 2.0 0.0

3033 WSB1:485 0 50 150 250

3036 ZNF74:761 40 80 120

0

3039 PARK7:188 400 800 1400

0

3042 TBCB:50 400 800

0

3048 XPO6:86 200 400

0

Slp = 3.72 Intcpt = 61

200 400 3041 TBCB:103 NM_015171 XPO6

Slp = 0.14 Intcpt = 872

NM_001281 TBCB

400 800 1200 3038 PARK7:134

Slp = 1.06 Intcpt = 54

400 800 3035 ZNF74:211 NM_007262 PARK7

0 20 60 100 3047 XPO6:174

0

0

0

Slp = 0.05 Intcpt = 67

0 100 300 3032 WSB1:166 NM_003426 ZNF74

Slp = 0.65 Intcpt = -13

NM_015626 WSB1

3034 WSB1:573 200 400 600

0

3037 ZNF74:121 0 200 600 1000

3040 PARK7:265 50 100 150

0

3043 TBCB:364 50 100 150

0

3049 XPO6:910 5 10 20

0

Slp = 0.17 Intcpt = 2

200 400 3041 TBCB:103 NM_015171 XPO6

Slp = -0.12 Intcpt = 142

NM_001281 TBCB

400 800 1200 3038 PARK7:134

Slp = 0.14 Intcpt = -8

400 800 3035 ZNF74:211 NM_007262 PARK7

0 20 60 100 3047 XPO6:174

0

0

0

Slp = 0.96 Intcpt = -3

0 100 300 3032 WSB1:166 NM_003426 ZNF74

Slp = 1.23 Intcpt = -23

NM_015626 WSB1

3034 WSB1:573 200 400 600 0 3037 ZNF74:121 0 200 600 1000 3040 PARK7:265 50 100 150 0 3043 TBCB:364 50 100 150 0 3049 XPO6:910 5 10 20 0 0

0

0

0

200 400 3048 XPO6:86

Slp = 0.05 Intcpt = 0

400 800 3042 TBCB:50 NM_015171 XPO6

Slp = 0.11 Intcpt = 6

NM_001281 TBCB

400 800 1400 3039 PARK7:188

Slp = 0.13 Intcpt = -13

40 80 120 3036 ZNF74:761 NM_007262 PARK7

Slp = 9.17 Intcpt = -592

0 50 150 250 3033 WSB1:485 NM_003426 ZNF74

Slp = 1.85 Intcpt = 8

NM_015626 WSB1 3033 WSB1:485 1.8 2.0 2.2 2.4 2.0 2.2 2.4 2.6 3032 WSB1:166 NM_003426 ZNF74

NM_015626 WSB1

1.6 1.8 2.0 3047 XPO6:174

2.3

2.5 2.7 3041 TBCB:103 NM_015171 XPO6

NM_001281 TBCB

2.90 3.00 3038 PARK7:134

1.0 1.5 2.0 2.5 3.0 3035 ZNF74:211 NM_007262 PARK7

3036 ZNF74:761 1.7 1.8 1.9 2.0 2.1 3039 PARK7:188 2.95 3.05 3.15 3042 TBCB:50 2.85 2.95 3.05 3048 XPO6:86 2.3 2.5 2.7

3034 WSB1:573 2.0 2.2 2.4 2.6 2.8 2.0 2.2 2.4 2.6 3032 WSB1:166 NM_003426 ZNF74

NM_015626 WSB1

1.0 1.5 2.0 2.5 3.0 3035 ZNF74:211 NM_007262 PARK7

3037 ZNF74:121 1.0 1.5 2.0 2.5 3.0 3040 PARK7:265 2.05 2.15

1.6 1.8 2.0 3047 XPO6:174

2.3

2.5 2.7 3041 TBCB:103 NM_015171 XPO6

NM_001281 TBCB

2.90 3.00 3038 PARK7:134

1.95

3043 TBCB:364 1.90 2.00 2.10 3049 XPO6:910 1.0 1.2 1.4 0.8

3034 WSB1:573 2.0 2.2 2.4 2.6 2.8 3037 ZNF74:121 1.0 1.5 2.0 2.5 3.0 3040 PARK7:265 2.05 2.15 1.95 3043 TBCB:364 1.90 2.00 2.10 3049 XPO6:910 1.0 1.2 1.4 0.8

2.3

2.5 2.7 3048 XPO6:86

2.85 2.95 3.05 3042 TBCB:50 NM_015171 XPO6

NM_001281 TBCB

2.95 3.05 3.15 3039 PARK7:188

1.7 1.8 1.9 2.0 2.1 3036 ZNF74:761 NM_007262 PARK7

1.8 2.0 2.2 2.4 3033 WSB1:485 NM_003426 ZNF74

NM_015626 WSB1

3055 TUBA1C:130 0 1000 3000

3058 TUBA1B:162 0 1000 3000

3064 PI4KB:804 10 20 30 40

0

0

0

5 10 15 3063 PI4KB:126

Slp = 2.05 Intcpt = 6

400 800 3057 TUBA1B:235 NM_002651 PI4KB

Slp = 2.45 Intcpt = 551

0 200 600 3054 TUBA1C:171 NM_006082 TUBA1B

Slp = 5.17 Intcpt = 91

NM_032704 TUBA1C

3056 TUBA1C:1282 0 400 800 1200

3059 TUBA1B:111 4000 8000 0

3065 PI4KB:970 20 40 60 0 0

0

5 10 15 3063 PI4KB:126

Slp = 2.20 Intcpt = 23

400 800 3057 TUBA1B:235 NM_002651 PI4KB

Slp = 4.11 Intcpt = 3271

0 200 600 3054 TUBA1C:171 NM_006082 TUBA1B

Slp = 1.28 Intcpt = 168

NM_032704 TUBA1C

3056 TUBA1C:1282 0 400 800 1200 3059 TUBA1B:111 4000 8000 0 3065 PI4KB:970 20 40 60 0 0

10 20 30 40 3064 PI4KB:804

Slp = 0.73 Intcpt = 25

0 1000 3000 3058 TUBA1B:162 NM_002651 PI4KB

Slp = 1.82 Intcpt = 2056

0 1000 3000 3055 TUBA1C:130 NM_006082 TUBA1B

Slp = 0.23 Intcpt = 170

NM_032704 TUBA1C 3055 TUBA1C:130 3.0 3.2 3.4 3.6

NM_032704 TUBA1C

0.8 0.9 1.0 1.1 1.2 3063 PI4KB:126

2.6 2.8 3.0 3057 TUBA1B:235 NM_002651 PI4KB

2.3 2.5 2.7 2.9 3054 TUBA1C:171 NM_006082 TUBA1B

2.4

3058 TUBA1B:162 3.0 3.2 3.4 3.6 3064 PI4KB:804 1.3 1.4 1.5 1.6

3056 TUBA1C:1282 2.2 2.6 3.0

NM_032704 TUBA1C

0.8 0.9 1.0 1.1 1.2 3063 PI4KB:126

2.6 2.8 3.0 3057 TUBA1B:235 NM_002651 PI4KB

2.3 2.5 2.7 2.9 3054 TUBA1C:171 NM_006082 TUBA1B

2.4

3059 TUBA1B:111 3.5 3.7 3.9 3065 PI4KB:970 1.4 1.5 1.6 1.7 1.8

3056 TUBA1C:1282 2.2 2.6 3.0 3059 TUBA1B:111 3.5 3.7 3.9 3065 PI4KB:970 1.4 1.5 1.6 1.7 1.8

1.3 1.4 1.5 1.6 3064 PI4KB:804

3.0 3.2 3.4 3.6 3058 TUBA1B:162 NM_002651 PI4KB

3.0 3.2 3.4 3.6 3055 TUBA1C:130 NM_006082 TUBA1B

NM_032704 TUBA1C