Artificial Query Sequence Set - PLOS

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S1 Query Sequence Set (QSS)

S1- Query Sequence Set derived from MEROPS

Artificial Query Sequence Set P3P2P1 tryptase gamma 1 KWR chymase FPF coagulation factor IXa EGR coagulation factor XIa EAR coagulation factor XIIa QGR complement component C2a LGR DESC1 peptidase EGR elastase-1 APA elastase-2 AAA granzyme A GPR granzyme B AAD granzyme H AAM hepsin LSR kallikrein 1 PFR kallikrein-related peptidase 11 PFR kallikrein-related peptidase 14 VPR kallikrein-related peptidase 2 ARR kallikrein-related peptidase 3 KVY kallikrein-related peptidase 4 VLK kallikrein-related peptidase 6 QAR kallikrein-related peptidase 7 RPY marapsin VGR matriptase EAR matriptase-3 FVR mesotrypsin GPR myeloblastin APV u-plasminogen activator LGR plasma kallikrein QRR plasmin GPK prostasin GPR protein C (activated) EPR testisin LTR thrombin VPR t-plasminogen activator LGR tripeptidyl-peptidase I AAF tripeptidyl-peptidase II AAF trypsin-2 GPR tryptase beta RNR

GPR

FVR AAA AAV

AAF FVR VLR

AAY

FLF

PFR RPY VLR FSR

PFR VPR

VPR GPR

GPK

GPR EGR

QAR

QGR

LGR

PFR

FSR GPR

FVR

GPM

FPA

KAK

AKR

AFK

Furin RAKR RCKR RDKR REKR RFKR RGKR RHKR RIKR RKKR RLKR RMKR RNKR RPKR RQKR RRKR RSKR RTKR RVKR RWKR RYKR RARR RCRR RDRR RERR RFRR RGRR RHRR RIRR RKRR RLRR RMRR RNRR RPRR RQRR RRRR RSRR RTRR RVRR RWRR RYRR

Tryptase beta PAKR PRNR PKAK PRNK

S1 Query Sequence Set (QSS)

Natural Query Sequence Set Training Set Octapeptide IIRRSLPA RAKRFASL VFRRDAHK RSRRAATS RPKRYNSG RQKRSINL RENRCQCA RSKRCSCS AKQRAKRD RKRRSLGD RRRRQLDP IRKRANSF VKKRSVSE HLKRDTED RGRRSLGS RKPRCGNP

Furin Tetrapeptide IRRS AKRF FRRD SRRA PKRY QKRS ENRC SKRC KQRA KRRS RRRQ RKRA KKRS LKRD GRRS KPRC

Tripeptide IRR AKR FRR SRR PKR QKR ENR SKR KQR KRR RRR RKR KKR LKR GRR KPR

Octapeptide SILRLAKA PHIRGNVG GRPRHQGV FGLRFYAY GHARLVHV IAGRSLNP VSPRASAS MIVRRAIK MRQRALST PNARSQPS SGQRGSSK AVARLSQR KRGRAPQV PQGRIVGG IQIRSVAK IEPRSFSQ IKPRIVGG KAPRVATS KPKDSSVD PLPRKAPL GKLRSPFL PALRSKLQ GGVRGPRV GDIRGPRI FSARGHRP NTGRSRGF GTARRYIG VQPRAQKI SRLRAYLL AHPRIISA MVPRAVYL FRPKHTRI AFPRVKPA SDPRGFGH VKNRSVYI AQNRSYSK PSSRSPST KAVRALKN QWARLLQT

Thrombin Tetrapeptide ILRL HIRG RPRH GLRF HARL AGRS SPRA IVRR RQRA NARS GQRG VARL RGRA QGRI QIRS EPRS KPRI APRV PKDS LPRK KLRS ALRS GVRG DIRG SARG TGRS TARR QPRA RLRA HPRI VPRA RPKH FPRV DPRG KNRS QNRS SSRS AVRA WARL

Tripeptide ILR HIR RPR GLR HAR AGR SPR IVR RQR NAR GQR VAR RGR QGR QIR EPR KPR APR PKD LPR KLR ALR GVR DIR SAR TGR TAR QPR RLR HPR VPR RPK FPR DPR KNR QNR SSR AVR WAR

S1 Query Sequence Set (QSS)

AEPKMHKT AMARALVQ AFSRGLLK ATPRLAST FNPRTFGS AVTRAKQI GSFRAGLF IDGRIVEG INVRKGGI ITVRGHNC KMLRGKPA PDLRSCVN PRSFLLRN QLGRIMLK VIPRSGGS YSNRSAAY

EPKM MARA FSRG TPRL NPRT VTRA SFRA DGRI NVRK TVRG MLRG DLRS RSFL LGRI IPRS SNRS

EPK MAR FSR TPR NPR VTR SFR DGR NVR TVR MLR DLE RSF LGR IPR SNR

S1 Query Sequence Set (QSS)

Octapeptide RKKREITE RRKRYAIQ RRKRYAEH RKRRSVNP RRKRAIMS RQKRFVLS RHRRALDT RAKRSPKH AKRRAKRD RSKRALEN RKRRSTNE RSKRSLSC

Furin Tetrapeptide KKRE RKRY RKRY KRRS RKRA QKRF HRRA AKRS KRRA SKRA KRRS SKRS

Tripeptide KKR RKR RKR KRR RKR QKR HRR AKR KRR SKR KRR SKR

Octapeptide LNARGLTS KAVRALKN PNARSQPS YGLRSKSK ITGRSRGF IFARGQSV QSARARLS TIPRAAIN LDPRSFLL SKGRSLIG PAPRGYPG MTPRSEGS MTPRSGGS MTPRSRGS LKLRTMLI QWARLLQT AVARLSQR QLGRIMLK YSNRSAAY LKPRVGKA YIPRILFL QGVRGYPT QGVRGYPT AEPRTVVS AVARLSQR MIVRRAIK LRPRFKII VDPRLIDG GRPRHQGV GRPRHQGV GRPRHQGV GRPRHQGV GRPRHQGV GRPRHQGV MIVRRAIK MIVRRAIK LSPRTFHP WYLRSNTG QGVRGYPT LIVRSATK ARPRHPAE LSPRGVHI QSPRSFQK

Thrombin Tetrapeptide NARG AVRA NARS GLRS TGRS FARG SARA IPRA DPRS KGRS APRG TPRS TPRS TPRS KLRT WARL VARL LGRI SNRS KPRV IPRI GVRG GVRG EPRT VARL IVRR RPRF DPRL RPRH RPRH RPRH RPRH RPRH RPRH IVRR IVRR SPRT YLRS GVRG IVRS RPRH SPRG SPRS

Tripeptide NAR AVR NAR GLR TGR FAR SAR IPR DPR KGR APR TPR TPR TPR KLR WAR VAR LGR SNR KPR IPR GVR GVR EPR VAR IVR RPR DPR RPR RPR RPR RPR RPR RPR IVR IVR SPR YLR GVR IVR RPR SPR SPR

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