Table of default simulation parameters Parameter Description ... - PLOS

Table 1: Table of default simulation parameters Parameter α β γ κ g Rcell τ  ka kb kc Ka Dρ Ntot DI k−I ρchar η d ∆t

Description Protrusion coefficient Retraction coefficient Cell tension coefficient Cell bending coefficient Cell-cell body repulsion coefficient Initial radius of cell Friction coefficient Phase field width Unitless base activation rate Overall activation rate Deactivation rate Positive feedback threshold for actin promoter (Rho GTPase) concentration Actin promoter (Rho GTPase) diffusion coefficient Total amount of actin promoter (unitless) Inhibitor diffusion coefficient Degradation rate of I characteristic scale of ρ Noise intensity Stripe width Numerical time step

Value 0.4 pN / µm3 0.2 pN / µm 1.8 pN 5 pN µm2 1 pN/ µm 9 µm 2.62 pN s / µm2 2 µm 0.01 10 s−1 10 s−1 1 µm−2 0.8 µm2 /s 800 0.5 µm2 /s 0.2 s−1 1 µm−2 0.02 µm/s 26 µm 0.004 s

These parameters are used throughout the paper; any deviation from them is explicitly noted.

1