R Graphics Output

Pathway: FRASOR_TAMOXIFEN_RESPONSE_UP There are 43 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): KLC1 Weight Factor: 1.253 Major Gene (NEG): WNT4 Weight Factor: 1.21

NEG ALL Major Gene (NEG): WNT4 Weight Factor: 1.389 Major Gene (BCR/ABL): KLC1 Weight Factor: 1.126

MST2 of the coexpression network for BCR/ABL ALL

MST2 of the coexpression network for NEG ALL

ZNF185 IER3 DAB2 ●SERPINA1 ● ● SRD5A1 KBTBD2 BHLHE40 ● ● CDK19 ● PGRMC1● LASP1 MSH2 ● RDX ● ● ● SDC1 ELF3 ● UPF1 GBE1 LSS ● ● ● PRPS1 EFNB2

●

GPR56 PKIA ● ● SHANK2

●

KLC1

●

●

YWHAZ RAB30 MECOM TM7SF2 ● ● LTBP1 KRT13● PTPRG ● SLC25A1 CD44 GGA2● ● ● ● ● WNT4 ● ASCL1 SUN2 ● RGS3 FARP1 ● ● SOCS1 ● ● IL13RA1● CDK18 STAG1

CPM

●

●

●

●

●

●

DAB2

● PRPS1

MECOM SLC25A1

●GPR56 ● ● PTPRG

MSH2 ● LTBP1 ●PGRMC1 CD44 ● ● ● FARP1 ZNF185SHANK2 ● CPM ELF3 ● ● ● ● RDX ● EFNB2 CDK19 GBE1 TM7SF2 YWHAZ ● ● SRD5A1 ● ● ASCL1 ● KBTBD2 ● ● BHLHE40 ● KRT13 IL13RA1 ● RAB30 UPF1 PKIA ● ● WNT4 ● ● IER3 STAG1 KLC1● SDC1 ● ● ● ● ● LASP1● SOCS1 LSS SUN2 ● CDK18 ● ● RGS3 SERPINA1 ● ● ● ● GGA2

●

Pathway: CHANDRAN_METASTASIS_TOP50_UP There are 15 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): EIF1AX Weight Factor: 1.375 Major Gene (NEG): HSP90AA1 Weight Factor: 1.218

NEG ALL Major Gene (NEG): HSP90AA1 Weight Factor: 1.312 Major Gene (BCR/ABL): EIF1AX Weight Factor: 1.192



G3BP1

AR

●

●

H2AFV RALA

●

●

TUBA1B

HSP90AA1 HSPD1

●

●

●

BASP1

●

EIF1AX

DDX17

TUBA1B

DDX17

●

●

HSP90AA1

●

GRB2

SOD1

G3BP1

●

CELF1

●

LARP1

●

●

●

H2AFV AR

●

● LARP1 GRB2

●

EIF1AX

●

● BASP1

●

●

●

●

● ●

HSPD1

SOD1

YY1

RALA

●

CELF1

●

YY1

●

Pathway: ROY_WOUND_BLOOD_VESSEL_UP There are 46 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): ANGPTL2 Weight Factor: 1.39 Major Gene (NEG): SLCO2A1 Weight Factor: 1.273

NEG ALL Major Gene (NEG): SLCO2A1 Weight Factor: 1.449 Major Gene (BCR/ABL): ANGPTL2 Weight Factor: 1.202



CYFIP2 CYR61 ● ● VCAN

CHN1 RAB31 ●

●

PEA15 VCAN ● ● STOM ATG4A ●

● CHN1

ANXA6 TES

● ● HEG1 COL5A2 ●

●

● XAF1 LUM POSTNGNA12 GBP1 ● ● ● THY1 ● ●MSX1 NRP1● ● ● ZWINT TIMP1 ● STC1 ● ● GALNT2CDH5 ● CYR61 CYFIP2 BMP1 ● ● ● SULF1 ● S100A4 ● ● ● FBXL7 DENND4B ● PLXDC1 ANGPTL2 ● ● FKBP1BPLAU● PCDH17 SEL1L3 ● ● ● NID2 ● ● ● COL3A1 MMP1 ● HYAL1 ● KDM5D ● SGCB COL4A1 ● ● ● ● ANGPT2 SLCO2A1 KCNJ8

FKBP1B RAB31 BMP1 ●

● KCNJ8

●

● ● SLCO2A1 THY1

MSX1 ● NRP1 HEG1 PEA15 ● STOM ● ● ● CDH5 DENND4B ● ● PLXDC1 NID2 GALNT2 GNA12 SEL1L3 COL5A2 ● ● ● ● ANGPTL2 ● ● XAF1 ● ANXA6 ● SULF1 FBXL7 ● ● ANGPT2 ● TIMP1 POSTN ● KDM5D● ZWINT GBP1 HYAL1 ● ● S100A4 ● ● STC1 COL3A1 ● ● ● COL4A1 PCDH17 ● ATG4A ● LUM ● ● TES SGCB ● ● ● PLAU ● MMP1●

●

●

Pathway: BILBAN_B_CLL_LPL_DN There are 31 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): RGS2 Weight Factor: 1.451 Major Gene (NEG): JUNB Weight Factor: 0.952

NEG ALL Major Gene (NEG): JUNB Weight Factor: 1.398 Major Gene (BCR/ABL): RGS2 Weight Factor: 0.874



CAPN3

●

MARCKS

●

● TCF7

●

FGL2 SULT1A1 ANXA1

HMGB2

●

●

ID2

●

● SAT1

SORL1

HOMER3

●

● JUNB

●

●

●

● MSL1

● ●

●

KLF4

GLRX

●

●

● ● PMAIP1 KLRK1 ● ●

SORL1 KLRK1 ●

●

HOMER3

●

ID2

●

●

ARHGEF6

FYN

●

● ●

JUNB

●

●

● IER3 ● ANXA1 FGL2 ●

●

● DUSP1 MNDA

FNBP4 PMAIP1 ●MARCKS SAT1 ● PRNP RGS2 ● ●

●

SFPQ TCF7

●

HMGB2 ACAP2 ● CNTNAP2 MSL1

FYN

●

FNBP4 PRNP

CNTNAP2 ● ACAP2

ZBTB20 ●

KLF4 ●

SFPQ IER3 RGS2 ●

●

ARHGEF6

●

ZBTB20

DUSP1

●

●

GLRX

●

FOS

●

MNDA

●

SULT1A1

EIF4A1

●

● CAPN3 EIF4A1

●

● FOS ●

Pathway: FARMER_BREAST_CANCER_CLUSTER_1 There are 35 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): CD3D Weight Factor: 1.471 Major Gene (NEG): IFI44L Weight Factor: 1.186

NEG ALL Major Gene (NEG): IFI44L Weight Factor: 1.472 Major Gene (BCR/ABL): CD3D Weight Factor: 0.77



IL10RA

●

CD2

CD48

●

TRBC1 CD38 ITK CD8A ● ● ● ● TNFRSF17 CD3D OAS2 GZMK ● CYTIP MX1 ● ● OAS1 ● CD2 ● ● GZMA ● LCK ● IFI44L ● ●

●

POU2AF1

●

IFI6

●

OASL

●

IFIT1 GMFG ●

●

CCR2

●

●

XAF1

●

CCR5

●

●

●

RSAD2

●

GPR18 LCP2

● SH2D1A IGJ GPR171

●

●

CD48 ● ● GPR18

●

●

● CD8A

TRBC1 TNFRSF17

● ●

● CD3DITKLCK ● ● ●

CD38

●

GPR171

IL10RA

●

●

IGHM

●

IGHM

● IFIT3

● GZMK

RSAD2

ISG15 IFI44

●

GZMA

IFIT1

● CYTIP CCR5 ●

LCP2

●

IGJ

●

POU2AF1 ● ●IFI44L OAS1IFI44 ● ● XAF1 IFI6 ● MX1 ● OASL GMFG ISG15 ● ● ● ● SH2D1A● IFIT3 OAS2● ● ● ● CCR2

●

Pathway: EINAV_INTERFERON_SIGNATURE_IN_CANCER There are 27 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): ISG15 Weight Factor: 1.383 Major Gene (NEG): MX1 Weight Factor: 1.335

NEG ALL Major Gene (NEG): MX1 Weight Factor: 1.3 Major Gene (BCR/ABL): ISG15 Weight Factor: 1.282



BRD3 MORC3 RXRA ●

UBE2L6 ERG

●

●

BST2

● ERG

● IFIT1

● SP100 ADAR

●

●

●

IFI6

●

IFIT3

●

OAS1

● EIF2AK2

● UBE2L6 FTSJD2

● OAS2

IFI44

●

TGIF1

●

●

●

●

●

●

● MX1 IFI44 ● ●

SP100

●

IFIT3 IRF9

SP110

EIF2AK2

●

●

● LY6E

ISG15

●

● IFI30

●

ADAR FTSJD2

IFI35 STAT1

● ●

APOBEC3G

● IFI30

SP110

IFI44L IFIT1 ●

MX1

ISG15 STAT1 IFI44L ●

●

●

IFI6

●

●

IRF9

OAS2 OAS1

●

●

●

●

IFI35 APOBEC3G LY6E

●

●

BST2

●

●

● TGIF1

●

● MORC3

●

RXRA

● BRD3 ●

Pathway: LIANG_HEMATOPOIESIS_STEM_CELL_NUMBER_LARGE_VS_TINY_UP There are 27 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): MANF Weight Factor: 1.404 Major Gene (NEG): GCAT Weight Factor: 0.662

NEG ALL Major Gene (NEG): GCAT Weight Factor: 1.235 Major Gene (BCR/ABL): MANF Weight Factor: 1.119



FCER1A

●

ICAM2● FKBP1A ●

●

ELOVL2

● SERPINE2GNG12GTF3A ●

●

●

●

IL1R1

BUB1 CDKN3 GBA ● ●

●

MSR1 PTTG1

●

ST6GALNAC4 DIO2

●

●

●

● MANF

●

●

ELOVL2

HSPA4 TLR6 RASGRP2 ICAM2 FADS1 ● ● ● ● F2RL3 ● PGAM1 GPAA1 ITGB1BP1

●

ST6GALNAC4

IL1R1

●

●PRTN3 ●

FKBP1A TMEM66 ●

● GCAT

●

●

HSPA4

● FCER1A DIO2

●

●

BUB1 PTTG1

●

GPAA1 CDKN3 GBA

●

● ●

TMEM66 PGAM1

F2RL3 ● ●

●

TLR6

MANFGCAT

●

●

GTF3A PRTN3 SERPINE2ITGB1BP1

●

●

●

●

GNG12

●

●

RASGRP2

●

● FADS1

●

MSR1

●

Pathway: MORI_SMALL_PRE_BII_LYMPHOCYTE_DN There are 47 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): SMC4 Weight Factor: 1.28 Major Gene (NEG): XPO1 Weight Factor: 0.985

NEG ALL Major Gene (NEG): XPO1 Weight Factor: 1.467 Major Gene (BCR/ABL): SMC4 Weight Factor: 1.351



NFATC3

PTPN22

PIP4K2A RHD NFATC3 HMBS ● ● ● CCND2 ● ● ● ASXL1 LCP1 IFRD2 TUBA4A CRIP2 ● ● SET● ● ● SSBP2 NUMA1 XPO1 ● NASP● ● S100A9 ● C1QBP RBBP7 ● DDX1 ● ● ● SMC4 ● ● HSPH1 ATP1A1 RPN2 ● ROM1 PSMB8 STIL ●EIF4E● ● RBL1 ● ●SEC61A1 WDHD1 ● GAPDH ● ● ● ● DNAJB1 MEF2C PDK1 MOGS● SLC20A1 RPS2 LUM● ● ● ACP1 ● SLC25A20 ● ● ● ● CD36 STAT4

ABR

●

IER2

●

● JOSD1 ● ID3

●

●

●

ATP1A1 HMBS

●ABR ● ● RHD RBBP7 ● IFRD2 JOSD1 ● DNAJB1 ● HSPH1 LUM ● ● SEC61A1 ● NASP ● PSMB8 ● ● NUMA1 ● EIF4E ● SET ACP1● ● ID3 ● CRIP2 ROM1 RPN2 TUBA4A ● SLC20A1 ● LCP1 ● C1QBP STIL ● ● STAT4 ● ●MEF2CSMC4 ● ● ● SLC25A20 ● ● RPS2 PDK1 XPO1 ● ●GAPDH DDX1 ● ● ● ● MOGS ● ASXL1 PIP4K2A PTPN22 ● ● SSBP2 ● S100A9WDHD1 ● CD36 ● ● ● ● CCND2 IER2 RBL1

●

●

Pathway: MORI_MATURE_B_LYMPHOCYTE_DN There are 45 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): CDKN3 Weight Factor: 1.481 Major Gene (NEG): CKS1B Weight Factor: 1.097

NEG ALL Major Gene (NEG): CKS1B Weight Factor: 1.389 Major Gene (BCR/ABL): CDKN3 Weight Factor: 1.378



SNRPB MPP1 HMGA1 IL7R SLC16A1 PSMC1● MYL4 ● ● ● SNRPC MTHFD2 ● ● PRPS1 ● PAFAH1B3 LGALS9 EZH2CD93 CCND3 ● ● ● ● DHFRPSMD8 ● ● ● ● H2AFZ IDH2 ● CDC25C ● H2AFV ● ● GFRA1 ● LITAF BRCA1 ● ● CDKN3 ● ● UCK2 NUDT1 RRM2

● ● ENPEP ● CKS1B MCM5 KIF2CCCNB1 ● ● ● PREP ● ● ● PLIN2 MYB LMNB1 ● ● ● ● TAX1BP3 RGS2 GAS7

● RNASEH2B

●

●

RAG2

MARCKS RAG1

●

●

LRMP

●

●

●

MARCKS ENPEP CCND3

●

PLIN2

●

● GAS7

●

PRPS1

CDC25C ● PAFAH1B3 MCM5

●

●

BRCA1

●

LGALS9

●

H2AFV EZH2

PSMC1 ● ● LRMP ● PSMD8● SNRPB GFRA1 ●RNASEH2B ● NUDT1 TAX1BP3 ● ● H2AFZ ● IL7R HMGA1 CD93 ● DHFR LITAF ● ● ● ● ●MYL4 PREP ● SNRPC ● ● MTHFD2 ● RAG2 ● SLC16A1 ● CKS1B MPP1 ● CDKN3 ● ● ●● LMNB1 RRM2 UCK2 ● CCNB1 ● ● ● RAG1 ● KIF2C IDH2 RGS2 ● ● ● ● MYB

●

Pathway: YAGI_AML_RELAPSE_PROGNOSIS There are 35 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): ECE2 Weight Factor: 1.39 Major Gene (NEG): TUG1 Weight Factor: 1.336

NEG ALL Major Gene (NEG): TUG1 Weight Factor: 1.475 Major Gene (BCR/ABL): ECE2 Weight Factor: 1.416



APLP2

TKT

●

● ATP6V0B

●

●

HSPE1

ENSA

NPC2

●

OGT

● LBR

● TSPO

●

VDAC1NME1

● NFKBIA

●

●

GRIK5

●

● TUG1 HOMER3 ●CD68 ●

ECE2XPO1 ● APLP2●

POLR2H● ● CLIP2 PGD ● ● BST1 ● TIAL1CDK6 ● ● ● PTP4A2

CD14

●

GABARAP

VAT1

●

● LUZP1

● HNRNPD TYMP CD14 ●

● ● ZYX

●

KAT2A

●

AZU1

●

RAB32

●

CDK6

● LUZP1 ●

HSPE1

● POLR2H XPO1 TYMP ● ● ● NME1

TUG1 CD68

● KAT2A ● ECE2 ● RAB32BST1 ● AZU1 GRIK5 ● VDAC1 ● ● TKT ● ● CLIP2 ● TSPO ● NFKBIA ENSA OGT ● PTP4A2 ● HNRNPD● ● TIAL1 ● ATP6V0B ● HOMER3 ● GABARAP ● ● LBR ● ● NPC2 ● ● PGD ● VAT1 ZYX ● ● ●

Pathway: HALMOS_CEBPA_TARGETS_UP There are 41 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): IL8 Weight Factor: 1.393 Major Gene (NEG): FOXA2 Weight Factor: 1.023

NEG ALL Major Gene (NEG): FOXA2 Weight Factor: 1.532 Major Gene (BCR/ABL): IL8 Weight Factor: 0.9



SLC16A7 POU4F1

● CXCL3 IL1R1 ● CKAP4 ●

● ADAM3A UGCG

EPHA4 ●

●

●

●

SERPINI1

●

ETS2●

●

●

●PTK2B RGS4 RAB27A ● ● ● ARL4A

●

FAS RGS2 CXCL2 ● BMP2K ● CCL20 IL4R IL8● ●

●

RAB32

SEMA3C

●

● BMP2

PTX3

ETS2

● ●TNFAIP8PLIN2 ● BTG1 ITGA1 ● ● KLF5 ● ● FOLR1 ● NFIL3 WAS UAP1 ● TLX1 FOXA2 ● ● ● ● SPDEF ● ● MEGF9 ●

JAK2

●

● KLF5

BMP2

ZNF250 RAB32 ● GLRX ●

GLRXIL4R EPHA4

●

●

●

ITGA1

TLX1 ● FOXA2 SPDEF JAK2 PTX3 ● IL1R1 MEGF9 ● ● POU4F1 ● ● ● SERPINI1 FOLR1 PLIN2 ● SLC16A7 ● ADAM3A SEMA3C ● ● WAS ● TNFAIP8 FAS ● ● ● ● ● CCL20 ● UGCG RAB27A ● UAP1 ZNF250 ● CKAP4 RGS4 ● ● ● ● ●

●

RGS2

● BTG1 ● NFIL3 ●

CXCL2

CXCL3

●BMP2K ● IL8 ● ● ARL4APTK2B ● ●

Pathway: KIM_LRRC3B_TARGETS There are 26 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): IFI27 Weight Factor: 1.316 Major Gene (NEG): ISG15 Weight Factor: 1.31

NEG ALL Major Gene (NEG): ISG15 Weight Factor: 1.426 Major Gene (BCR/ABL): IFI27 Weight Factor: 0.787



HLA−DPB1

EIF3E

●

CD74

HLA−E

●

HLA−DQB1

●

●

●

●

●

●

●

●

●

OAS2

IFITM2

●

●

●

PSME2 ●

●

ISG15 FTH1

●

CD59

●

●

● CD59

●

●

● IFIT1 IFI27

EIF3E●

●

●

●

●

● B2M

●

HLA−A

●

TAPBP

FTH1 IFI44

CCL5

●

●

TAP1 IFI44ISG15 ● HLA−E●

●

●

● EEF1A1

SERPINA1

●

OAS2

GM2A

●

IFIT1

● SERPINA1

CCL5

C9

●

C9

CXCL1

●

●

IFI16

CD74

CXCL9

● TAPBP

EEF1A1

●

IFI27

GM2A B2M

HLA−DQB1 ●

IFI16 TAP1

HLA−A

CXCL9

● HLA−DPB1

IFITM2

●

● PSME2

●

CXCL1

●

Pathway: AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G There are 71 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): IL2RG Weight Factor: 1.532 Major Gene (NEG): SYDE1 Weight Factor: 1.047

NEG ALL Major Gene (NEG): SYDE1 Weight Factor: 1.526 Major Gene (BCR/ABL): IL2RG Weight Factor: 0.988



OAZ2 ANXA5 ● GABARAPL1 ● GTF3A PLK2 CKAP4 LAMC1 NFE2L1 ● RNF11 ● ● ● KIF21B DENND5A ● ● GMFG ● LAPTM5 ● TPBG RDX SSBP1 SH2D2A ● ● ELF1 ● ● PSD4 FXR1 SWAP70 ● ● PMP22 CORO1A ●● ● IL6ST ● ● FAM114A1 GAS2L1 WWOX GJC1 SYDE1 ENOSF1 ● ● ● ARHGEF17 ● ● ● NCKAP1L ● TULP3 ● BMP1 HCLS1 ● DOCK1 ● TSPAN4 PRKX IL2RG MFNG ● ULK2 TFAP2A ● ● ● ● U2AF2 ● ●● ● ● ● CD53MAX ADRBK1ABI2 PFN2 ● DAG1 LAMB2 LCP1 ● ● ●VAMP3 ● CST7 BCAR3 ● ● SEMA3C ●● SGK1 ● GNG12 ● AKAP12 ● WWTR1 CCND1 ● ● IGSF3 CD44 INPP5D ● LOXL2 PTPN7 ● AMOTL2 ● ●DIP2C ● ● ● ● ITGAV ● MPDZ ● ● CDK6 ●SMARCA1 ●

●

●

PFN2 CORO1A KIF21B● ARHGEF17 HCLS1 ● BCAR3 ●GAS2L1 DAG1 AKAP12 ● CD44 ANXA5 PTPN7 ● ENOSF1 ● WWOX ● CD53 ● ● ULK2 ● ● CKAP4 DOCK1 U2AF2 ● ● LAPTM5 PMP22 ● ●●VAMP3 FAM114A1LAMB2 ● BMP1 ● CST7 IGSF3 CCND1 ABI2 ● TSPAN4 ● ● ●SH2D2A DENND5A ● ● MAX● ●PRKX ● ● ● SYDE1 ● ● PLK2 IL6ST ●SGK1 ●● TPBG CDK6 DIP2C RNF11 OAZ2 ● ● ●TULP3● GJC1 ● ● NFE2L1 ● GABARAPL1 GTF3A ● ● GNG12 ELF1●LCP1 TFAP2A ●INPP5D ● LOXL2 ● ●● ● ●AMOTL2 SWAP70 IL2RG WWTR1 ● ● ● SMARCA1ADRBK1 ● ● LAMC1 ● ● ● ● GMFG ITGAV FXR1RDX ● SSBP1 ● ● MPDZ ● ●

●

● PSD4 NCKAP1L ● SEMA3C ● MFNG

●

●

Pathway: CHUNG_BLISTER_CYTOTOXICITY_UP There are 75 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): ATOX1 Weight Factor: 1.435 Major Gene (NEG): SOD1 Weight Factor: 1.429

NEG ALL Major Gene (NEG): SOD1 Weight Factor: 1.392 Major Gene (BCR/ABL): ATOX1 Weight Factor: 1.176



SLC1A4

● RAB13PLIN2 FABP5 ATF5 RFK CKS2 ● GNA15 GGA2 ● ● ●PGRMC2 TBL2 ● ● ● SDC4CD81 PHYH ● ● ● COX5A CTSL1 ● COPS8 ● RALA GZMB AKR1A1 ●C1QB CTSC● PSMD14 ● ● CDKN1A ● ● ● CLTA CD3D● PGAP1ACP5 ● GNLY ● GALNT2 ● SYT11 ● CRIP1 ●PDE4A CD8B ● ● TCF12 SERPING1 ● ASMTL SHFM1 FANCL ● ● ● ● ●TNFAIP3ETFB ● ATOX1 ● PSMB2 ●RBBP8 ● ●ZNF410 TMED9 CD86 NUDCD3 ● SLC11A2 ● ● TPI1 ●GCHFR ●● ● ● ● ● ● CYB5A SOD1 MDC1 PPP1R7 ● GPR137B STRA13 MT1E ●MYO7A ● ● ● ALDH6A1 PCK2 CCR5 PSMC1 ● MT1F ● ● ●IRAK1 ● ● USP11 CBLB ● ●PSMD2CD96 ● MCM5 ● CTSB PSMD13 ● ● ● ●DDB2 MRPL9 ● ● ● ● ILVBL ●

●

CTSL1 TNFAIP3 CCR5 ATF5 SERPING1● CDKN1A ● ● GPR137B ●ASMTL RALA MRPL9 ZNF410● ● IRAK1 CTSB PGAP1 ● ● PSMD2 ● ● ● PCK2 GNA15● PSMC1 SYT11 ● ● CKS2 ● ● PLIN2 STRA13 PPP1R7 ● RBBP8 ●COPS8 ● ● TBL2 ● ALDH6A1ATOX1 ● COX5A ● ● ●SHFM1 ETFB CTSC PSMB2 ● CRIP1 ● FABP5●AKR1A1 ● USP11 ● MCM5 CD81 TPI1 ● ● ● ●PHYH ● ● CBLB ● TMED9 ● PSMD14 ●● ● ILVBL ● ACP5 SOD1 CD3D ● RAB13 DDB2 ● CD86 ● GNLY ● ● ● ●PSMD13 SLC1A4 ● ● CLTA SDC4 FANCL ● GZMB TCF12 MYO7A ● NUDCD3 CD96 ● ● ● CYB5A CD8B GALNT2 ● ●● ● ● GGA2 C1QB ● PGRMC2 ●● ● RFK ● ● MDC1 PDE4A ● ●GCHFR SLC11A2 ● MT1F

● ● ● MT1E ● ●

Pathway: BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP There are 72 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): LRP3 Weight Factor: 1.418 Major Gene (NEG): PHIP Weight Factor: 1.279

NEG ALL Major Gene (NEG): PHIP Weight Factor: 1.482 Major Gene (BCR/ABL): LRP3 Weight Factor: 1.321



IL12RB2 NEDD4L ● IL24 HIST1H1C TTC39A ● ● PSMA2AURKA GALNT3 ● RAB27A ● TEP1 POLR2A SMOX ● TNFSF14 PTTG2 ● SNRPA1 ● PPP1R12BHIST1H2AE CBX3 ● HSPA5 ● ● ● EGR1 PCMT1 ● ● CCNB1 ● PDE4C ● DLGAP5 ● ● HSP90AA1 PNN TFRC ● GP2 ● ● PLEKHB2IER3● ● ● GNG11 GALNT2 ● ANXA1 ● ● TNPO1 NEK2 ● ● BUB1 ● MAD2L1 CTNNAL1 FGFR1OP FOS ● ● ● ● ● ● PHIP ● ● ● LIMK1 ● ALG13 CDC6 NDUFA9 PCNA RAMP1 ● CDC20 NRAS ● ● ● TACSTD2 ● LRP3 ● MAPK1 LSM6 ● NDUFAB1 ●MYBL2 CALR ● TCEB3 NACC2 ● ● API5 ● ● ● PSMA3 ● ● SOD2EIF2S1 ● ● ● KYNU HCK ● CYR61 SPC25 ● FAP DKK1 ● ● ● ● ● FAM3C ● ● GCLM WWTR1 ● SPARC ● ●

●

GNG11 RAB27A

●

API5● SPARC NEDD4L ●SPC25 DKK1 CTNNAL1 ● FAP ● ● HCK GCLM ● FAM3C ● MYBL2 SNRPA1 ● ● ●NRAS WWTR1 ● LRP3 CDC20 ● ● KYNU ● SOD2 PLEKHB2 TCEB3 ALG13 ● ● PCNA ● ● ● GALNT2 ● LIMK1● ● PTTG2 POLR2A ● ● ●PDE4C IL12RB2 ● IER3 ● ● PCMT1 GALNT3MAPK1 TNFSF14 AURKA PHIP ● ● PPP1R12B ● NDUFA9 ● PNN ● TNPO1 MAD2L1 ● DLGAP5 ● EIF2S1CCNB1 ●NACC2 ● TEP1 ● GP2● ● ●● ● TTC39A ●RAMP1 ● PSMA3 CDC6 ● NEK2NDUFAB1 ● HSP90AA1 EGR1 PSMA2 BUB1 HIST1H2AE CBX3 ● ●● ● FGFR1OP ● ● ● LSM6 ● ● IL24 ● ●● ● CYR61 ● TFRCHSPA5 ● FOS SMOX ● ●TACSTD2 HIST1H1C ANXA1 ● ● ● CALR ● ● ●

●

Pathway: PARK_APL_PATHOGENESIS_DN There are 37 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): SPI1 Weight Factor: 1.388 Major Gene (NEG): PRTN3 Weight Factor: 1.013

NEG ALL Major Gene (NEG): PRTN3 Weight Factor: 1.46 Major Gene (BCR/ABL): SPI1 Weight Factor: 1.432



SLC29A1

PRKCA

●

CORO1A

● NEU1

SRF

GAL

●

●

QSOX1

●

●

GPI RAB27A MCAM CKAP4IL32 ● ●

●

●

●

● ● RAB27A ● SPI1 ZYX SIRPA NFKBIE ● ● ● MCAM ● SLC20A1 FKBP5 PPP5C ● ● IL8 ● ● COL4A2 ● GLUL ● LYST ● ● ● SRGN ●

ASAH1

●

ELANE

●

SMOX

IL32 CES1

SRF

● APP MNDA BTG1 ● CKAP4 CYBB● RAB31 VAT1 ● S100P PRTN3 ● ● ● SLC29A1 ● ● ● GPNMB ● ●

●

RAB31

●

GPNMB SPI1 NFKBIE SLC20A1 ● ● PRTN3 PRKCA CYBB ● SIRPA ● ● ● ● QSOX1COL4A2 ● ● PPP5C ZYX ● ● ELANE ● CES1 SMOX ●

●

GPI

●

CORO1A

APP

●

●

NEU1 IL8 ●

VAT1

● ●

GLUL ASAH1S100P LYST

● BTG1 FKBP5 ●

●

MNDA

●

●

SRGN

●

●

GAL

●

● ●

Pathway: HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP There are 32 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): NCF4 Weight Factor: 1.459 Major Gene (NEG): XPO1 Weight Factor: 0.718

NEG ALL Major Gene (NEG): XPO1 Weight Factor: 1.428 Major Gene (BCR/ABL): NCF4 Weight Factor: 1.064



MFHAS1

HES1

HES1

●

●

● MAPK8IP3 SUCLG2

CD83PRPS1CD40

●

●

● ●

●

CD36

●

CD40

●

PEPD SLC2A3 MAPK8IP3 ●

●

●

FLII

LTB CD36 ●

PRTN3 ● SIPA1 CTSH NCF4 ● ● SERBP1 ● ● ● CD22 ● MEF2C SCD ● MS4A1 ● ● HMBS MYOG ● SEMA4D VEGFB ● ● LEFTY1 ● ● SDC4 SUCLG2 RHOD ● XPO1 ● ● ● NEDD4 ● GGA2 CCND2 ● ● ●

●

SERBP1

●

LEFTY1

● HMBSMFHAS1 MYOG SDC4

●

●

●

CCND2

FLII

● XPO1 ●

LTB

CTSH

● MS4A1

● NEDD4 ● ● SIPA1

● SLC2A3 PEPD SCD ● ● ● CD83 PRPS1● ● GGA2 PRTN3 CD22 MEF2C ● ● RHOD ● ● ● NCF4 ●SEMA4D ● ● VEGFB ●

Pathway: VALK_AML_WITH_FLT3_ITD There are 31 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): IL1RAP Weight Factor: 1.335 Major Gene (NEG): HOXB3 Weight Factor: 1.118

NEG ALL Major Gene (NEG): HOXB3 Weight Factor: 1.364 Major Gene (BCR/ABL): IL1RAP Weight Factor: 0.745



LCT

MAP1A

●

●

TRIM16 ENPP2

●

●

APP GOLGA8A IL2RA ●

LAPTM4B HOXB2

●

●

●

GPR56 COL4A5 HOXB5 HOXA5 ● MAGED1 ●

●

LGALS3BP NR6A1

●

COL4A5

● SOCS2 PDE4B

●

●

● HOXB6 TRPC2 ●

HOXA4

●

●

●

● GOLGA8A

●

HOXB5

●

ADCY2

MMP2 TRIM16 ● ● TRPC2

●

SEPP1

●

LYRM1 QPRT

●

●

●

HOXB6

●

MAGED1

SOCS2

PIM1 HOXB3

● ●

●

●

IL1RAPLCT

PDE4B NR6A1

●

SMC4

● HOXB3 LYRM1 MMP2 ● ● ●

ADCY2

●

●

●

GPR56

PBX3

IL2RA

●

LGALS3BP

●

●

SEPP1 QPRT

●

●

HOXB2 ● ●

● IL1RAP ● PBX3 ● ●

● ●

ENPP2 HOXA5

PIM1

●

SMC4

● HOXA4

APP

●

●

MAP1A LAPTM4B

●

●

Pathway: HAHTOLA_CTCL_CUTANEOUS There are 22 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): PSMB3 Weight Factor: 1.326 Major Gene (NEG): MMP9 Weight Factor: 0.979

NEG ALL Major Gene (NEG): MMP9 Weight Factor: 1.478 Major Gene (BCR/ABL): PSMB3 Weight Factor: 0.986



●

●

CD160

●

RPL31

●

●

S100P

●

●

ARPC1A TOP1

GLIPR1

● ●

TRIB1

●

●

STAT1

●

SNCA PSMB3 ●

HBD

●

MMP9

● PSMB3

●

●

C1QBP SNCA ● ETHE1 ●

●

●

HBD

●

STAT1

TOP1

RPL31

TRIB1

ITM2A

●

●

RECQL

●

BARD1

●

ARPC1A

HIST2H2BE

GLUL

ZBTB16

ETHE1

●

G0S2

●

HIST2H2BECDC42

● GLIPR1

●

●

ITM2A

●

C1QBP

●

● MMP9

● CD160

●

ZBTB16

●

G0S2

S100P

● BARD1

● ●

RECQL

●

CDC42

●

GLUL

●

●

Pathway: ZHAN_MULTIPLE_MYELOMA_LB_DN There are 28 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): IFI35 Weight Factor: 1.298 Major Gene (NEG): XAF1 Weight Factor: 1.259

NEG ALL Major Gene (NEG): XAF1 Weight Factor: 1.494 Major Gene (BCR/ABL): IFI35 Weight Factor: 1.338



STAT1

IFI6

LY6E●

●

BASP1

●

MX2

PSMB10

CASP4

HIF1A ● IFI35 SEPHS1 IFIT5 ● ● PTPRCAP ● ● TACC1 ● XAF1 IRF1 ● ● ● ● SMAD1

CASP4 ZMIZ1

GTPBP1

●

DUSP6

●

MAN1C1 CAP1 TRAF5

● WIPF1

●

● CCR2

●

●

LOC643733

●

STAT2

RSAD2

●

●

CAP1

●

TACC1

●

MAN1C1 GTPBP1

●

STAT2

●

RSAD2

●

●

IFI35 PTPRCAP ●

● CCR2

●

LY6E ● XAF1

●

●

IFI6

STAT1

DUSP6

● ●

●

●

●

●

IFI27

●

MX2

IFI27

●

IFIT5

●

●

●

TRAF5

●

IRF1

●

BASP1

●

PSMB10 LOC643733

●

HIF1A ZMIZ1 ●

●

●

SEPHS1

● WIPF1

●

SMAD1

●

Pathway: ZHU_CMV_24_HR_DN There are 54 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): PYCR1 Weight Factor: 1.337 Major Gene (NEG): COL6A2 Weight Factor: 1.225

NEG ALL Major Gene (NEG): COL6A2 Weight Factor: 1.654 Major Gene (BCR/ABL): PYCR1 Weight Factor: 1.317



CDH11 COL1A2 ● ID2 ● COL3A1● THBS2 MITFPTPN13 ● ADM ● ● IGF1R AHR ● BCL2 ● ●EFEMP1 SERPINE1 ● GAS1 TFAP4 ● ●CD151● XPC ● ACO1 ● ● ●ANXA1 PDGFRA IGFBP5 MN1 ● TNFRSF1A ● WEE1 EPO ● ● POSTN ● CYP1B1 ● ● COL6A2● TAGLN TIMP3 PAFAH1B1 MATK ●COL5A2 PYCR1● LAMB2 ● SGCG TGFBR3 ● ● ● ● ● TRAM2VCAN ● HSD17B2 ● ● ● RAB13 CCND1 ● ● TPM4 ABL1 PTGIS ● ● CRHBP ANPEP ● ● ● ● RUNX1 ● PABPC1 ● NR3C1 THBS1 TNNI3 ● ● ● ● FLNATPM1 ●

●

●

TGFBR3 ADM

●

● FLNARUNX1 ANXA1TFAP4 BCL2 ● ● ● TRAM2 ACO1 ● NR3C1 PTPN13 THBS2 ● ● TPM4 CDH11 TPM1PDGFRA ● TNFRSF1A ● RAB13 ● ● ● ● ● ●TNNI3 MN1 ● AHR ● ● CD151 ● ● CCND1 IGFBP5 EFEMP1 LAMB2 PYCR1● GAS1 SERPINE1 ● ● ● ABL1 ● ● ● MATK COL6A2 CRHBP ● ● ANPEP ID2 IGF1R EPO ●PAFAH1B1 ● THBS1 ● ● ● ● ●XPC ● COL5A2 TAGLN ● PTGIS COL3A1 ● ● ● WEE1 ● TIMP3 ● POSTN VCAN HSD17B2 ● CYP1B1 COL1A2 ● ●

●

● ●MITF SGCG ● PABPC1 ●●

●

Pathway: ZHU_CMV_ALL_DN There are 72 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): TIMP3 Weight Factor: 1.335 Major Gene (NEG): COL6A2 Weight Factor: 1.145

NEG ALL Major Gene (NEG): COL6A2 Weight Factor: 1.642 Major Gene (BCR/ABL): TIMP3 Weight Factor: 1.336



ACVR2A TNNI3 ● MITF ● MMP1 COL3A1 PTPN13 ● TRAM2 ● ZFP36L1 AR ADM COL1A2 MATK ● TP53BP1 ● ● XPC● ● ● ● EPO● CDH11 ADH1B CCND1 ● ● TIMP3 HNMT PYCR1 ● ●ENG● COL6A2 IGF1R ● ● FBLN1 WEE1 ● ● RAB13 EFEMP1 ● NR2F2 BMP4 ●ERCC5 ● ● IGFBP5 LAMB2 ● ●TFAP2A● ●ANP32A TAGLN CYP1B1 ● POSTN ●● IGFBP2 TGFBR3 ● ● ID2 GAS1 RUNX1 ● ● COL5A2 ● ● ● ●THBS2 PTGIS PAFAH1B1 ● TNFRSF1A ● ● SGCG ● TPM4 TPM1 ● ● NR3C1 ● ● ●● MAPK14 ACO1 ●BCL2 AHR PDGFRA ● CD151 ANPEP HSD17B2 ● ●● SERPINE1 MN1 ●● ● ● FLNA ● MARCKS ABL1● ● ● CRHBP VCAN ANXA1 ● TFAP4 THBS1● PABPC1 ● ● ● CEBPD

● ●

●

●

NR2F2 MITF PTPN13 COL3A1 ID2 COL1A2 ● PABPC1● MMP1 SGCG ● ● ● GAS1 BMP4 ● COL5A2 ● ● ● TFAP2A EFEMP1WEE1 ● HSD17B2 TIMP3 ● FBLN1 ● ● CYP1B1 POSTN THBS2● ● LAMB2 ● CCND1● PYCR1 ANPEP ● ADH1B ● ● CDH11● ● THBS1 ● MATK IGFBP5 ● ● ● ● TPM1 ZFP36L1 ● COL6A2 ERCC5 AR ● RAB13 PAFAH1B1 EPO ● ●ABL1 ● MAPK14 ● TP53BP1 ● ●● ● ● ●● VCAN PTGIS ● CRHBP TAGLN ● AHR● FLNA CD151 IGFBP2 ● MARCKS HNMT TRAM2 ● TNNI3 ● XPC ANP32A ● ● ● ● ● ● ● ● TPM4 IGF1R ● ANXA1 SERPINE1 MN1 RUNX1 ● PDGFRA ● TFAP4 ● ENG ● ● ACO1 BCL2 ● ● TGFBR3 ● TNFRSF1A NR3C1 ● ● ● CEBPD ● ●ACVR2A ● ● ADM

●

●

Pathway: LIANG_SILENCED_BY_METHYLATION_2 There are 31 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): OAS1 Weight Factor: 1.425 Major Gene (NEG): IRF7 Weight Factor: 0.911

NEG ALL Major Gene (NEG): IRF7 Weight Factor: 1.489 Major Gene (BCR/ABL): OAS1 Weight Factor: 1.418



IL13RA2 DAZL●

ICAM1

STC1

MMP1 ● UCHL1

●

●

TNFSF10

●

C1S ● IL13RA2DAZL UCHL1 ● ● ● ● SSX3

● SSX3 HIST1H2AC SLPI

●

●

IFIT3 ●

● STX3 S100A4 OAS2 ● XAF1 ● ● C1S DHRS2 ● TNFAIP3 ● ● NT5E ● MCAM

●

●

●

STC1 SP100

●

●

●

●

●

CCL5

●

●

SLPI STX3 MCAM HIST1H2AC

●

● OAS2

●

DHRS2

●

●

●

NT5E

●

SP100 ● ● IFI44L IFIT3 ●

MX1 IRF7 MX2 ● OAS1 ● STAT1 ●

XAF1

●

●

●

●

S100A4

CCL20 CCL5

●

HBEGF CXCL2 TNFAIP3 ●

MX1 IRF7

● CXCL2 ● CCL20 ● HBEGF ● ● ICAM1

●

MX2 IFI44L STAT1

● OAS1

●

●

MMP1

TNFSF10

●

●

Pathway: BROWNE_INTERFERON_RESPONSIVE_GENES There are 67 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): ISG15 Weight Factor: 1.34 Major Gene (NEG): ISG15 Weight Factor: 1.34

NEG ALL Major Gene (NEG): ISG15 Weight Factor: 1.469 Major Gene (BCR/ABL): ISG15 Weight Factor: 1.469



CXCL10

PML

● SP100

●

●

●

IFI44 EIF2AK2IFI6 RSAD2 ● LMO2 ●TRIM22 IFIT2IFI44LCASP1 ● ● RABGAP1L SAMHD1 ● ZBTB20 ● ● ● IFI27 GMPR ● RBCK1 RGL1 PLSCR1 TREX1 TRIM14 ●ISG15 ● ● ● ● STAT1 MX1 ● ●SP110 TDRD7 ● IDO1 ● ● ● MX2 IRF7WARS ● ● OASLIFIT3 HLA−FTYMP ● ● ● IFI35 ● ● GBP1 ● MYD88 ● ● MELK ● ● OAS1 ● IFI30 TRIM21 ●OAS2 ● BAZ1A XAF1APOBEC3G ● UBE2L6 ● ● TNFSF10 ● ●TAP1 ● TLR3 RARRES3 ● ● PSMB8 ●KIF5C GBP2 ● ● ● ●STX11 PSMB9 NMI ● GCH1 ● ●CYTH1 CCL8 ● ● ● ● IL15 BST2 PDZD2 ● ● CXCL11 IL15RA ● ● CXCL10 ●

●

●

● IL15 KIF5C ● TNFSF10

IFIT5 ISG20

●

●

IFIT2 TLR3 WARSSTX11 ● GBP2 ●TRIM21 GBP1 PLSCR1 IFIT5 TYMP ● TREX1 ● ● ●TDRD7 ● OASL ● CXCL11 IFIT3 STAT1 ● ● ● PDZD2 ● PSMB8 EIF2AK2 ● ● ● IFI44 ●CCL8IFI35APOBEC3G ● XAF1 ● MELK ● ● OAS1 MX1 RSAD2 RARRES3 ● PSMB9 ● ● ●● UBE2L6ISG15 ● ●PML ● IFI44L MX2 ● ● ● IDO1 ● ●OAS2 ●IRF7 ● IFI6 SP100 ● ● BST2 ● ● GCH1 ● ● IL15RA CYTH1IFI27 ● ● ISG20 BAZ1ATAP1 RBCK1 ● SP110 ● ● MYD88 ●RGL1● ●NMI ● GMPR ● HLA−F ●TRIM22 ZBTB20 ● ● RABGAP1L ● LMO2 ● ● TRIM14 ● SAMHD1 ● ● IFI30

● ● CASP1 ●

●

Pathway: KRASNOSELSKAYA_ILF3_TARGETS_UP There are 29 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): IFI35 Weight Factor: 1.379 Major Gene (NEG): ISG15 Weight Factor: 1.216

NEG ALL Major Gene (NEG): ISG15 Weight Factor: 1.432 Major Gene (BCR/ABL): IFI35 Weight Factor: 1.026



TUBB

●

●

●

STAT1 MX1 ● IFI35 ●

●

●

BLZF1

CTSO

●

IFIT3

HLA−E

● RGS4 TSPAN8

●

●

IFITM1

●

IFI27

●

●

● NT5E IFI16

●

TAP1

●

APOE

● FAP TBX5

●

●

PROS1

●

●

●

HLA−E IL6ST

XAF1

●

● CTSO

●

●

● MX2

IFI27●

FAP

● STAT1

IFI35 PROS1

●

●

ISG15

MX1

●

● ●

●

TRIM22

XAF1

OAS1 ●

●

IFI16 TAP1 IFIT3 ● OAS1 ●

● HIST1H2AC ●

CLEC2B

ISG15 MX2

●

RGS4

BLZF1

●

CD79A EMP1

●

● TBX5

APOE

● ● TRIM22 HIST1H2AC ● IFITM1 ●

●

NT5ETUBB

●

CD79A

●

●

CLEC2B TSPAN8

●

●

IL6ST EMP1

●

●

Pathway: GENTILE_UV_RESPONSE_CLUSTER_D4 There are 48 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): PUM1 Weight Factor: 1.528 Major Gene (NEG): PUM1 Weight Factor: 1.528

NEG ALL Major Gene (NEG): PUM1 Weight Factor: 1.422 Major Gene (BCR/ABL): PUM1 Weight Factor: 1.422



SNRNP40 AURKA CCNB1

SIAH1

CCNB1

● ZFP36 DDX17 MAPK6RAB1A ● ● ARF6 ● AURKAKRIT1 BHLHE40 ● ● ● DDX3X KPNA2 GNE ● BMPR1A UAP1 ● ● ● ● ● ● USP1 ● HMGB2 PPP2R5C PDCD10 SEC24B PUM1 ● EEF1E1 ● HMGA2 SAMD4ASNRNP40 CLINT1 ● ● RBM5 ● ● ● RAD21 ● PHC2 ● ● ● ● ARID5B RAPGEF2 USP10 SPEN ● ● ● CTGF ● ATP13A3 ● GATA2 ● GNAI1 ● ATP2A2 ● UBE2G1 ● DICER1 ● CHSY1 POGZ ● ● ● XPO1 ● ● ●

●

FILIP1L

●

KANK1 SLC20A2 FZD7 ● TPST1●

●

●

TPST1

●

●

●

EEF1E1

USP10

●

POGZ GNAI1 CHSY1 XPO1 ● ARID5B ● ●DICER1 PDCD10 ● CTGF PPP2R5C ● ● SPEN ● UBE2G1 ● USP1 ● UAP1● GATA2 ● PHC2 ● HMGB2 SEC24B ● ● ATP13A3 ● ● RAPGEF2 KANK1 ● ● RAD21 ATP2A2 RBM5 PUM1 ZFP36 MAPK6 ● ● ● KPNA2 BHLHE40 ● ● GNE SAMD4A CLINT1 ● ● ●DDX3X ● ● RAB1A KRIT1 ● SIAH1● ● ● DDX17 ARF6 BMPR1A ● ● HMGA2 ● FILIP1L ● ● ● FZD7 ● ● SLC20A2 ●

●

●

Pathway: KEGG_BLADDER_CANCER There are 42 genes in this pathway. This pathway was detected by Both

BCR/ABL ALL Major Gene (BCR/ABL): VEGFB Weight Factor: 1.495 Major Gene (NEG): TYMP Weight Factor: 1.16

NEG ALL Major Gene (NEG): TYMP Weight Factor: 1.491 Major Gene (BCR/ABL): VEGFB Weight Factor: 1.348



EGFR

MMP1 MDM2 MAP2K1 ● EGFR ● ● MAPK3 ● DAPK1 MMP2 DAPK3

●

●

● ● E2F1 MYC ● ● E2F3 EGF PGF MMP9 CDKN2A DAPK2 ● TYMP E2F2 ● ● ● ● ● NRAS ● ERBB2 ● VEGFA BRAF VEGFB RAF1 ● CDH1 ● ● ● TP53 RPS6KA5 ● ● ● MAPK1 IL8 ARAF ● ● FIGF ● ● THBS1 CDK4 CCND1 ● VEGFC ● KRAS HRAS ● ● ● CDKN1A ● ● ● MAP2K2 ● RB1 ● ● RASSF1 ●

FGFR3

●

● FIGF ● VEGFC FGFR3 ● MMP1

NRAS

●

● RAF1 BRAF CCND1 ● RASSF1 MMP9● DAPK3 CDKN2A ● ● ● DAPK2 ● HRAS TYMP MYC ● ● CDK4 E2F3 ● CDH1 MAPK1 ● MAP2K2 ●● MMP2 ● ● E2F2 ●TP53 ● KRAS VEGFB THBS1 DAPK1 ● RB1 ● ● MAPK3 PGF ● ● ● ● ● RPS6KA5 EGF ● ● ● MDM2 E2F1 ● ● ARAF ERBB2 ● ●

●

● VEGFA

●

IL8 ● CDKN1A MAP2K1

●

●

Pathway: GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREY_DN There are 40 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CROT Weight Factor: 1.42 Major Gene (NEG): GRAP Weight Factor: 1.077

NEG ALL Major Gene (NEG): GRAP Weight Factor: 1.411 Major Gene (BCR/ABL): CROT Weight Factor: 1.32



PDGFB

ARL4A

● CXCR7

SORBS2

● HOXA5 ● PCDH17 PPP1R3C ● MECOM ● RHOBTB3 ● ● AURKB ZMYND8 ● FLRT2 TFAP2A SOX4 RUNX1T1 FAM49A DUSP10 ● ● ● ●● ● LOC730101 ● IFIT1 ● CROT ● GBP1 ● EVI2B SMAD7 ● STAT1 PLIN2 ● RAPGEF5 ● ● MT1F ● ● PGRMC2 IFIT3 ● GJA5 ● STK38L GRAP PDGFB ● ● ● ● ● ●METTL7A LMO2 FOXC1 ● ● TBX1 IFIT5● AGPS ● ● ● TNK2 LYPD1 ● ●

●

LOC730101 GJA5 LYPD1● ● ZMYND8 ● TBX1 ● PGRMC2 ARL4A GRAP ● MT1F ● SORBS2 ● ●SOX4 RAPGEF5 ● RUNX1T1 MECOM ● TNK2 ● CROT ● PPP1R3C ● TFAP2A GBP1 ● ●RHOBTB3 ● AURKB DUSP10 ● ● IFIT5 ● EVI2B ● ●STK38L ● ● FLRT2 SMAD7 ● FAM49A IFIT1 STAT1 ●

●

●

●

CXCR7 HOXA5 FOXC1 ● PLIN2 ● METTL7A

●

● ●

LMO2

●

PCDH17

●

●

●

IFIT3 ● AGPS

●

Pathway: GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP There are 22 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CXCL3 Weight Factor: 1.419 Major Gene (NEG): CXCL6 Weight Factor: 0.744

NEG ALL Major Gene (NEG): CXCL6 Weight Factor: 1.475 Major Gene (BCR/ABL): CXCL3 Weight Factor: 1.297



TRA2B CXCL13

● CCL19

●

SOD2

●

JUN● ●

●

●

ANXA5

●

●

IL8

● NFAT5

●

CXCL2

● CCL20

RGS1 ●

●

●

●

CXCL6

JUN

●

●

●

CCL8

● CRHBP CCL20

TRA2B

● CXCL13CXCL1 ● ●

● CCL19

● CCL8

●

IL8

●

●

● TNFSF4

PCDH9

● CXCL3

CXCL6 CXCL5

●

●

CXCL1

CRHBP

NFAT5

●

PCDH9

●

ANXA5

● CXCL3 CXCL5 ●

●

IL1B

SOD2

●

●

EMP1

●

TNFSF4

CXCL2

RGS1

●

HIST1H2AC EMP1

IL1B

●

●

HIST1H2AC

●

Pathway: ZIRN_TRETINOIN_RESPONSE_WT1_UP There are 15 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): ZNF133 Weight Factor: 1.407 Major Gene (NEG): PDGFRA Weight Factor: 1.02

NEG ALL Major Gene (NEG): PDGFRA Weight Factor: 1.286 Major Gene (BCR/ABL): ZNF133 Weight Factor: 0.885



DLC1

TAL1

● ETV1

●

CAPN7

●

●

SMAD3

●

RARB

AKAP12 SMAD3

●

IGFBP3

●

ITGA1

●

PDGFRA

●

●

DLC1

●

ZNF133

●

●

ZNF133 DHRS3●

●

●

●

ETV1

●

●

ITGA1 RARRES1

●

● ●

●

DHRS3

IGFBP6 KIT

KIT

●

●

●

●

RARB

TAL1 PDGFRA

CAPN7

RARRES1

IGFBP3

●

IGFBP6

AKAP12

●

●

Pathway: MAHADEVAN_RESPONSE_TO_MP470_UP There are 18 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CXCL3 Weight Factor: 1.294 Major Gene (NEG): IFI44L Weight Factor: 0.794

NEG ALL Major Gene (NEG): IFI44L Weight Factor: 1.413 Major Gene (BCR/ABL): CXCL3 Weight Factor: 1.127



VCAM1

CXCL5

● ●

●

CXCL6

CXCL10

● VCAM1

CXCL5

RSAD2

●

●

● CXCL10

OAS1

●

CXCL3

●

IFI44L

MX2

●

PTX3 PTX3

●

IL8

OAS2

SOD2

●

●

● XAF1

●

●

CXCL3

SOD2

●

IL6

● CXCL1

●

RSAD2

● IFI44L

CXCL1

● CCL5

● ●

●

●

●

●

● ASNS

IL8

CXCL6

●

MX2

● OAS1

●

IL6

●

XAF1 CCL5

●

ASNS ● ●

OAS2

●

Pathway: APPIERTO_RESPONSE_TO_FENRETINIDE_UP There are 23 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): HSPA8 Weight Factor: 1.429 Major Gene (NEG): CCL13 Weight Factor: 0.833

NEG ALL Major Gene (NEG): CCL13 Weight Factor: 1.458 Major Gene (BCR/ABL): HSPA8 Weight Factor: 1.114



CYB5R1

●

●

HSPA4

●

FOXJ3

MYO1E

AKAP9

●

HSPA8

● STXBP3 CYR61

● ITGAX

MMP3

●

●

●

●

●

●

●

MGP

●

●

● TSC2 GAD1 ● ●

●

●

●

CCL13

●

AHSA1

●

●

●

GAD1

● MYO1E

●

SDC4

BRD2

●

● ●

MMP3

● ITGAX

● HSPA4 TFRC ● ● STXBP3 AKAP9

CYR61

●

HSPA8 PSMC4

CCL13

● PSMA7

MGP

CYB5R1 PRKACB

UCHL1 AHSA1

●

●

UCHL1

●

●

SDC4

●

●

TM4SF1

BRD2

PSMC4●

TFRC

PSMA7

TSC2

PRKACB

FOXJ3

●

●

TM4SF1

●

Pathway: SCHLOSSER_MYC_TARGETS_AND_SERUM_RESPONSE_DN There are 46 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): EBNA1BP2 Weight Factor: 1.463 Major Gene (NEG): NCL Weight Factor: 1.19

NEG ALL Major Gene (NEG): NCL Weight Factor: 1.408 Major Gene (BCR/ABL): EBNA1BP2 Weight Factor: 1.324



HSPA9

BAG2

FBL ADCY3

●

● EIF1AX ● DDX21 CSE1L AMD1 PRKRIR UTP18 CUL1 ● ● SYNCRIP ● ● ● TRIM14 ● ● ● PRNP TFDP1 DKC1RRS1 PA2G4 ● ● ● ● ● AKAP1 CEBPZ ● MYC TIMM17A ● ● ● ● LDHA PAICS RSL1D1 HDGF ●EBNA1BP2 ● PPAT RPIA NOP14 EXOSC7● ● BAG2 ● ● ● FTSJ1 ● PDIA5 ● ● PRDX4 FABP5 ● RPP40 ● UCHL3 ● ● IRAK1 ● ● MRPL19 ● ODC1 NCL SRRM2● ● SRPK1 ● ● MXI1 RAN ● BYSL ● ● ●

● SRPK1 MYC ● RSL1D1 ●

HDGF

●

CUL1●

SRRM2 DKC1 CSE1L ADCY3 ● ● PDIA5NOP14 EIF1AX LDHA● ● ● ● ●AKAP1 FTSJ1● TRIM14 AMD1 SYNCRIP MXI1 ● PA2G4 UTP18 ● EXOSC7 ● ● BYSL ● ● FABP5 PRNP ● UCHL3 ● ● ● ● ● NCL RAN PPAT ● PRDX4 RPP40 PAICS IRAK1 ● ● ● EBNA1BP2 ● PRKRIR ● ● HSPA9 ● CEBPZ RPIA MRPL19 ● ●

●

● RRS1 ●

●

TFDP1

●

●

FBL

●

●

ODC1 TIMM17A ● DDX21

●

●

Pathway: DAUER_STAT3_TARGETS_UP There are 36 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): LBP Weight Factor: 1.262 Major Gene (NEG): LBP Weight Factor: 1.262

NEG ALL Major Gene (NEG): LBP Weight Factor: 1.539 Major Gene (BCR/ABL): LBP Weight Factor: 1.539



STAT3 AGT

●SERPINB3

FGG PLIN3 SERPINB3

●

●

AKAP12

FGG

●

IGFBP1 ●

●

●

PPAP2B●

IGFBP1

●

CCL2 ● TRIB1 ● SFN GFPT2 BCL6 ● SAMD4A SOD2 LBP ● ● ● ● SLC4A7 UGCG ● TEAD4 ABCA1 NPC1 ● FGA

●

●

CEBPD

●

●

● SLC2A3

●

● LDLR DUSP5 ● ZFP36

●

ATF3 ●

● JUN ●

●

THBS1 CTSB

PFKFB3 ● PPAP2B ● ICAM1 ● ●

●

EFNA1 ADM

●

●

BCL3

●

●

SFN

ICAM1

● GFPT2

STAT3

● BCL3 ● TEAD4 ● LBP ● ● ● PLIN3 PFKFB3 ABCA1 CCL2 SOD2 ● FGA AGT ● ● ● ● ● ● UGCG TRIB1 THBS1 AKAP12● ● CTSB● DUSP5 EFNA1 SAMD4A ● ● ● ZFP36 ● CEBPD ● BCL6 ● SLC2A3 LDLR ● ● ADM NPC1 ● SLC4A7 ● ● ATF3 ● ● JUN ● ●

Pathway: SIMBULAN_UV_RESPONSE_NORMAL_DN There are 29 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CCNF Weight Factor: 1.377 Major Gene (NEG): ITGB4 Weight Factor: 1.076

NEG ALL Major Gene (NEG): ITGB4 Weight Factor: 1.421 Major Gene (BCR/ABL): CCNF Weight Factor: 1.398



GRB7

●

HAS2 MYC ITGA6 ● ● ● TP63 EGFR CDH1

●

●

●

●

●

THBS1

MARCKS

●

MN1

● ID1

●

ITGB4 ●

●

●

TACC1

VEGFA● MCL1 ●

PLEC

● RBMS1

● ● GADD45B ADRB2 ● ● ENC1

●

PIP4K2B

AHNAK

●

●

MCL1

●

MN1

MARCKS HAS2 POLR2A ● FAT2 ● ●

●

PHLDA1 EMP1 ● DUSP7

CCNF

●

●

●

●

● AHNAK TACC1 VEGFA ●

ITGA6

POLR2A

●

RBPMS FAT2

GADD45B

EMP1

●

GRB7

●

●

● THBS1 DUSP7

RBPMS

●

●

●

RBMS1 PHLDA1

● ● ITGB4 ● PIP4K2B

CCNF

●

TP63

●

PLEC

●

●

ID1

● MYC

●

EGFR

●

CDH1

● ENC1 ADRB2

●

●

Pathway: BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_UP There are 18 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): HELZ Weight Factor: 1.272 Major Gene (NEG): GRB7 Weight Factor: 0.715

NEG ALL Major Gene (NEG): GRB7 Weight Factor: 1.415 Major Gene (BCR/ABL): HELZ Weight Factor: 1.051



FKBP4

●

CDH1

JAK2

●

ERBB2

● ●

●

●

DHCR7

TFAP2A

GRB7

DOCK3

●

●

● TFAP2A

● NRGN

●

●

UST

UBE2L3 ● HSPA8

●

●

UBE2L3

●

SCARB1

●

HELZ

SCARB1

HELZ MMP24 MYBPC2

●

●

●

FKBP4

●

●

DOCK3

MYBPC2

YWHAB●

●

●

GRB7

MMP24

●

DHCR7 JAK2

●

RPIA

●

●

RPIA

CDH1

●

●

HSPA8

● UST

●

NRGN

●

ERBB2

●

YWHAB

●

Pathway: RADAEVA_RESPONSE_TO_IFNA1_UP There are 31 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): IFI35 Weight Factor: 1.492 Major Gene (NEG): IRF7 Weight Factor: 0.846

NEG ALL Major Gene (NEG): IRF7 Weight Factor: 1.321 Major Gene (BCR/ABL): IFI35 Weight Factor: 1.19



IFITM3

HLA−E

IFITM1 ● CXCL10

●

ADAR TNFSF10

●

IL12RB2 ● ADAR

●

BCL2

IFITM2

IRF7

●

● UBE2D3 MX1

●

E2F2

●

MX2

● IRF1

●

PLSCR1

●

BAX

●

IFI27

●

PLSCR1

●

IFITM1

●IFITM3 IRF7 ● IRF1 IFI44L ● STAT1 ● CALR ●

MX1

●

●

IFI27

● ●

KLK3

● HLA−E

TNFSF10●

●

RFC2

●

STAT1

PSME1

● CDKN1B IFI35

●

●

CALR

CXCL11

● ● IFI44L

●

●

● PIAS4

●

●

BST2

VCAM1 RRP8 ●

●

● MX2 ●

●

●

● ●

● PIAS4

●

UBE2D3

●

●

●

●

CXCL10

●

BAX ● CDKN1B

KLK3 ● E2F2 ● BCL2 ● ● IL12RB2

BST2

●

RFC2PSME1

IFI35

CXCL11

VCAM1

●

IFITM2

●

RRP8

●

Pathway: MOOTHA_VOXPHOS There are 68 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): UQCRQ Weight Factor: 1.361 Major Gene (NEG): NDUFA2 Weight Factor: 1.338

NEG ALL Major Gene (NEG): NDUFA2 Weight Factor: 1.356 Major Gene (BCR/ABL): UQCRQ Weight Factor: 1.299



SDHD ● NDUFC1 NDUFB5 ● NDUFB3 UQCRB ● SDHCNDUFB1 ● COX7C ● ATP5B COX4I1 ● ● ● COX6B1 ● ● SDHBNDUFS3 ● ATP5O NDUFA5 COX10COX7A2 COX7A2L ATP5J● ● COX8A ● ● UQCRFS1 NDUFA1 ● COX7B NDUFA6 ● ATP5F1 ● ● ● ATP5L UQCRC2 NDUFS5 ● ● ● ● ATP5C1 ● ATP5H NDUFB8 ● ● ● ● NDUFA7 COX5A COX5B ● ● ● NDUFB6 COX6A2 NDUFS4 NDUFA2 ● ATP5I ATP5G3 ● UQCRQ ● COX6C UQCR11 ● BCL2L1 ● ● ● ● UQCRH ●NDUFA9 ●● ● ATP5D TBCB NDUFS7 NDUFAB1 ● ATP5G1 UQCRC1 CYC1 ● SDHA ● ● NDUFB7 CYCS ● ●NDUFS8 NDUFS6 ● ● ● COX11 ATP5G2 NDUFS1 ●ATP5J2 ● ● ● ●● ●● MBD3 ● COX7A1 BCS1L ● SURF2 ● CYB5A ● ● ● NDUFS2

●

ATP5J2 CYB5A ● ● NDUFB5 ●COX4I1 ● CYC1 COX11 COX7A2 COX7A1 ATP5C1 COX8A ● ATP5G2 NDUFS6 ● ATP5LNDUFS4 ● UQCRH COX7C COX7B ● ● ● CYCS UQCRFS1 ATP5F1 COX6C COX10 ● ● ATP5O ● ATP5I ● COX7A2L ● ● ● COX5A ● NDUFB8 ● NDUFS1 ATP5G3 ● NDUFA1 ● ● UQCRC2 ● ● ● ● ● ● NDUFA7 ● COX5BATP5J NDUFA5 ● ● UQCRQ NDUFA2 ● SDHD NDUFA6 ● ● ATP5G1 ●ATP5D ● ● SDHBBCS1L ● COX6B1 ● ●NDUFB1 ● NDUFS2 SURF2● UQCR11 ● ● NDUFB3 ● ● NDUFS3 ●UQCRB ● ATP5H NDUFC1 ● UQCRC1 ●● ● ● MBD3 ● NDUFAB1 NDUFS8 ● TBCB SDHA ● ● NDUFB6 ● ● SDHC ● NDUFS7 NDUFB7 ● ● NDUFA9 ● ● BCL2L1 COX6A2 ● NDUFS5

●

● ATP5B ●

Pathway: CROMER_METASTASIS_UP There are 47 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): ZFC3H1 Weight Factor: 1.436 Major Gene (NEG): XPO1 Weight Factor: 1.02

NEG ALL Major Gene (NEG): XPO1 Weight Factor: 1.532 Major Gene (BCR/ABL): ZFC3H1 Weight Factor: 1.253



ZBED1 PGRMC1NFYC ● ●GANAB CXCR4PPT1 ●TFAP2C DEK SH3BGRL MFGE8 ● ● ● ● ● PARP1 ENPP2 KIFAP3 ● ● TBCE EID1 ● TCF12 CD164 ● SH3BP5 MFAP3

●

● ATRX

● FADS2 TMEM63A ● MTMR2

● ● TUBB2B ● CD46 ● BMI1 ● ●

● ● XPO1

●

ZFC3H1 TMEM123 UBXN4 FERMT2 SLC25A36 DYRK1A ● ● ● WAS ● CNN3 ● ●

● ● CTNNB1 ● PPIH ● ARHGDIB CCND3 ● ● FCGRT SLC2A3 ● ● KDM5C BUB3 ● ● ● ID2 ● ● CDH11 ●

PTPRK

●

SMC1A

●

ATRX PTPRK

●

CDH11 ●

TMEM63A MTMR2 CTNNB1 ●●

●

FERMT2ARHGDIB

●

●

FADS2

● ENPP2 SLC25A36 WAS CNN3CD164 ● PPIH ● PGRMC1CD46 ● DYRK1A ● ● ● SH3BP5 ● CCND3 ●TMEM123 UBXN4 BUB3 ● ● ● ID2 SLC2A3 DEK ● ● ●TFAP2C ZFC3H1 ● SH3BGRL ● TCF12 ● PARP1 ● ● ● ● CXCR4 MFGE8 ● XPO1 BMI1 EID1 TUBB2B ● ● ● GANAB ● ZBED1 ●PPT1● ● SMC1A KDM5C KIFAP3 FCGRT ● ● ● NFYC ● ● ● TBCE ●

●

MFAP3

●

●

Pathway: NAKAMURA_METASTASIS_MODEL_DN There are 25 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): FGFBP1 Weight Factor: 1.274 Major Gene (NEG): RUNX2 Weight Factor: 1.035

NEG ALL Major Gene (NEG): RUNX2 Weight Factor: 1.453 Major Gene (BCR/ABL): FGFBP1 Weight Factor: 1.38



SFXN3 LDLR

●

CALCA

●

●

TFPI SERPINB1● PLAT

●

AQP3

●

GLI3

●

ALDOC CAST

●

●

CD44

DDB2

TGFB1I1

●

UGCG

●

●

WIPI2

●

NTSR1

●

DDB2 PMP22

●

●

CD44

●

RAC2 ●

UGCG RRAGD●

●

● WIPI2

●

LDLRSERPINB1

● CAST

●

●

SFXN3

●

AQP3

●

● CALCA

TFPI

●

MUC2 GLI3 PTHLH ●

● ●

FABP5

●

●

ALDOC

PTHLH RAC2●

●

●

●

●

● PLAT

PTPRZ1

MUC2

PTPRZ1

●

●

●

RUNX2

FGFBP1

●

●

●

●

RRAGD

FGFBP1 FABP5 RUNX2 ●NTSR1 TGFB1I1

PMP22

●

●

Pathway: LU_TUMOR_ANGIOGENESIS_UP There are 22 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): JAG1 Weight Factor: 1.417 Major Gene (NEG): VAV2 Weight Factor: 1.318

NEG ALL Major Gene (NEG): VAV2 Weight Factor: 1.449 Major Gene (BCR/ABL): JAG1 Weight Factor: 1.117



CCNE1

CCND2

●

VCAN

●

●

EZH2

●

CXCR4

●

●

FGFR1

● ● FGF18 ●

TNFAIP6

●

ITGAV STC1

●

●

●

CCND2

●

●

●

●

STC1 JAG2

●

● VEGFA

MMP9

●

●

●

TYMPVAV2

CXCR4 ●

TNFAIP6 PDGFA

JAG1

●

●

FYN

●

●

E2F3

SPP1 FYN

●

CD44

● E2F3

VAV2

TYMP

●

ITGAV

MMP9

●

●

● ●

PTK2

CCNE1 EZH2

VEGFA

VCAN

PDGFA

●

CD44

● FGF18

SPP1

●

●

●

JAG2

●

●

JAG1 PTK2

●

● FGFR1

●

Pathway: CADWELL_ATG16L1_TARGETS_UP There are 56 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): ADIPOQ Weight Factor: 1.395 Major Gene (NEG): DBH Weight Factor: 0.979

NEG ALL Major Gene (NEG): DBH Weight Factor: 1.434 Major Gene (BCR/ABL): ADIPOQ Weight Factor: 0.813



FABP1

●CYP2E1 TERF1 IFIT1CD36 ● SLC5A12 KIF3B ● MTTP ● ● PLEKHM1 PDZK1 ● PTGER3 BST1 ●● ADIPOQ ● ● ● CHST1 ● LHFPL2 PCDH17 UPK1B HSPA12A ● SCP2 ● GZMB● ● ● ●SCD RSAD2 FCGRT VNN1 SAA1 ● ● ● ● ● CD163 ●EXOSC10 THPO ●SASH3 KRT12 FABP4 ALPI ● ● ● ● ● LEPTMEM87A ● APOA1 ● POU4F1 LTK ● ● NEUROD2 ZKSCAN1 ● ● ● DHH LPL ● APOA4 ● DBH SOCS3 NPR3● APOC2 CST6 ● ● ● HP● ● RBP4 ● TRIM15 ●XIST ● ● CFD IL5 ● CXCL1 ● ● ● PHF21A ● CIT ● ●

MTTP

●

KRT12 TERF1 CD36 CYP2E1 SCDUPK1B ●SLC5A12 ● ● ● SCP2 ● ●THPO● HSPA12A ADIPOQ ● VNN1 ● ● FABP1 CD163● LTK PDZK1 ● ALPI ● ● NEUROD2 ● BST1 ● LEP SAA1 KIF3B ● XIST EXOSC10 ● ●● FABP4 ● ● APOA4 CHST1 ● POU4F1 ● ● APOA1 NPR3 ● ● ● DBH ● ●TRIM15 IFIT1 ● ZKSCAN1 TMEM87A CST6 ● ● LPL PHF21A SASH3 ● ● HP●PTGER3 APOC2 ● SOCS3 ●DHH RSAD2 ●IL5 ● ● ● ● ● PCDH17 ● ● CXCL1 LHFPL2 RBP4 FCGRT CFD ● ● PLEKHM1 ●

●

●

●

●

GZMBCIT

● ●

Pathway: GU_PDEF_TARGETS_DN There are 24 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PARVA Weight Factor: 1.484 Major Gene (NEG): ITGB4 Weight Factor: 1.042

NEG ALL Major Gene (NEG): ITGB4 Weight Factor: 1.377 Major Gene (BCR/ABL): PARVA Weight Factor: 1.24



INHBB

FOXA1 KRT7

● SMURF1

●

● KRT18 FOXC1

●

●

●

●

PIK3R3

● KRT8

● CDH3

●

KRT19

VEGFC

●

●

● PIK3R4

● FOXC1

KRT18

KRT8

● CDH3

●

●

NKX2−5

●

FZD5

●

TGFB2

ITGB8

● EIF2B2 CDH1 ● ●

PIK3R4●

●

●

PARVA

ITGB4 THBS1

PIK3CB

●

VEGFC

● ●

●

FZD5

KRT19

●

FOXA1

INHBB TGFB2

●

PIK3CB

●

CDH1

●

ITGB4

●

●

●

EIF2B2

●

EIF1AX SMURF1 PIK3R3

●

●

●

THBS1ITGB6

●

● KRT7

ITGB8 EIF1AX

NKX2−5

●

ITGB6

●

●

●

● PARVA

●

Pathway: MILI_PSEUDOPODIA There are 29 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CYB5R3 Weight Factor: 1.327 Major Gene (NEG): SEPT7 Weight Factor: 1.27

NEG ALL Major Gene (NEG): SEPT7 Weight Factor: 1.43 Major Gene (BCR/ABL): CYB5R3 Weight Factor: 1.361



PPFIA1

EIF3E

EIF2A

DYNLT3 RAB13

●

●

●

● VAMP7

● SAMD4A

●

SSB

●

PALLD KIF1C DKC1 ●

●

●

●

●

●

● ●

DDR2 BMI1

●

RGS20

●

●

●

XAF1

● CYB5R3

●

PKP4

●

●

GAB2

PPFIA1 ●

●

KIF5B

●

SAMD4A

SEPT7

SH3BGRL

●

CCNG1

●

KIF5B

PALLD

●

●

CENPB

EIF2A

●

●

CCNG1

KIF1C

CYB5R3

●

● ZEB1 EIF3E ● XAF1 SEPT7 RAB13 ● ● ● ● MAP2K7 ● APC HTATSF1 SSB ● ● ● CCND2 RGS20 ● DKC1 ● ● ● ●

CCND2 MAP2K7 HTATSF1

INPP1

●

GAB2

CENPB

● ZEB1

●

BMI1

DYNLT3

SH3BGRL

●

● ●

APC

●

DDR2

VAMP7

● INPP1

●

PKP4

●

Pathway: VALK_AML_CLUSTER_5 There are 24 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): LILRB3 Weight Factor: 1.344 Major Gene (NEG): TYMP Weight Factor: 0.907

NEG ALL Major Gene (NEG): TYMP Weight Factor: 1.429 Major Gene (BCR/ABL): LILRB3 Weight Factor: 0.704



IFNGR2

CCR1 KCNQ1 ●

●

●

● VCAN ●

●

●

●

SIRPB1

VDR LILRA1

LILRB2

●

●

●

STS

●

●

HNMT

●

SIGLEC7

●

LILRB1

●

● KCNQ1

TYMP CCR1 TFEB

●

●

●

EPB41L3

●

●

VDR

●

HNMT

●

● CAMK1

●

UBE2D1

●

●

VCAN

●

STS

●

PSAP UBE2D1 ●

SIRPA

CD86

●

● EPB41L3

●

● SIGLEC7 ●

LILRB1 SMPDL3A

●

●

TFEB

LILRB2 LILRA1 ● PTAFR

● LILRB3 SMPDL3A ● SIRPB1 ●

IFNGR2 CD86

●

●

●

TYMP

LILRB3 GNS

●

●

●

SIRPA

CAMK1

PTAFR PSAP

GNS

Pathway: VALK_AML_CLUSTER_11 There are 28 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): APP Weight Factor: 1.504 Major Gene (NEG): CD200 Weight Factor: 0.816

NEG ALL Major Gene (NEG): CD200 Weight Factor: 1.317 Major Gene (BCR/ABL): APP Weight Factor: 0.729



IFITM1

LHFPL2

● DPYSL2

● REEP5 MDFIC

●

●

DAPK1 FYN

●

DAB2

●CD34

●

●

ITGA6

●

KLF9

ASS1 ●

●

●

ST3GAL5

●

SERPINB9

●

DNM1

PALM

●

●

● ● KYNU

●

●

●

●

●

APP

● ●

DAB2 SPARC ● ● ASS1 ● SERPINB9ALDH2

CIITA

● KLF9

●

CLIC4

● ST3GAL5 ●

●

MDFIC

●

FYN CD200●

REEP5

●

●

● DUSP7

PALM

VEGFA H1F0

H1F0

●

●

GAS2L1

CD200●

● CLIC4

● CIITA

●

DAPK1

GAS2L1 KCNN4

●

CD34

●

●

IFITM1●

DNM1

●

KYNU

APP

● ALDH2 LHFPL2

●

KCNN4

ITGA6

●

SPARC ● DUSP7

●

●

VEGFA

DPYSL2

●

Pathway: VALK_AML_WITH_CEBPA There are 29 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CD7 Weight Factor: 1.39 Major Gene (NEG): CAMP Weight Factor: 1.12

NEG ALL Major Gene (NEG): CAMP Weight Factor: 1.537 Major Gene (BCR/ABL): CD7 Weight Factor: 1.435



SEL1L3 HOXB2

CD38

●

●

CEBPA

●

●

●

●

SLC16A1

DLC1

●

●

●

B4GALT6 MMP8

●

●

MEST

●

ATN1●

●

IGHM CEBPA IGLL1 ● HOXB2 ● ● SEL1L3 ●

● SUCLG2 CTNNA1●

CD38

● BASP1

●

●

HSPB1

● SFXN3 ITM2A ●

●

TBL1X

●

●

●

PGLYRP1

CAMP

MMP8 B4GALT6

●

GALC GNA12 ●

●

CD7 ● CEACAM8

BASP1

ATN1 ● ● GNA12 TRIB1 ● CAMP SUCLG2 LCN2 ● ● ● SLC16A1 CD7 ● ● HPGDS LTF ● ● ● CEACAM8 ● PGLYRP1 ● ● TBL1X

●

LCN2

●

● ITM2A

●

●

DLC1

IGHM MEST

TRIB1

HPGDS

● CTNNA1HSPB1

GALC

●

●

IGLL1

●

SFXN3

LTF

●

●

Pathway: ZHAN_MULTIPLE_MYELOMA_LB_UP There are 17 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): RASGRP1 Weight Factor: 1.289 Major Gene (NEG): CSF2RB Weight Factor: 1.144

NEG ALL Major Gene (NEG): CSF2RB Weight Factor: 1.335 Major Gene (BCR/ABL): RASGRP1 Weight Factor: 0.625



NTHL1

●

CACNB3

ARID5B

●

●

ARID5B BIK

●

●

● ●

●

● MBD2

MBD2 SLC39A6

● ARNT2

●

CSF2RB COL9A2

●

PLS1

●

MAST4 P2RX5

●

●

●

●

●

●

MAST4 BIK

NTHL1

RASGRP1

CGREF1

●

CSF2RB

● ●

●

● KIAA0895

COL9A2

● SLC39A6

FLNB

NAMPT

●

KIAA0895

RASGRP1

CGREF1

●

NAMPT

ARNT2

●

●

FLNB P2RX5 ●

●

PLS1 CACNB3

●

●

●

Pathway: URS_ADIPOCYTE_DIFFERENTIATION_DN There are 27 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): ROM1 Weight Factor: 1.409 Major Gene (NEG): COL6A1 Weight Factor: 1.326

NEG ALL Major Gene (NEG): COL6A1 Weight Factor: 1.38 Major Gene (BCR/ABL): ROM1 Weight Factor: 1.355



THBS2

LOXL1

●

●

THBS1

●

●

SNN

LRP5

●

ROM1 COL6A1 ● E2F4

LOX

CD37 CEBPA

●

●

●

PTPRN ADORA1

●

LRP3

●

●

LRP5

MMP9

●

PPP2R1AMMP2

PTPRN

●

SPARC

●

●

● ● COL3A1 MMP9 ● E2F4 ● THBS4 ● ●

●

CD37

●

ADORA1

ROM1 ● COL6A1 LRP3

FN1

●

●

COL4A2

LUM

●

●

●

●

MMP2

●

PPP2R1A●

●

●

●

PSG9

PPARD

PSG9

●

●

●

●

● SNN

PTGDS

FN1

●

THBS2

●

LUM

●

●

●

COL6A3

●

COL6A3

SPARC●

LOXL1

COL3A1

●

PPARD

LOX

PTGDS

THBS4

CEBPA

●

● ●

THBS1

●

COL4A2

●

Pathway: JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN There are 34 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): BMP6 Weight Factor: 1.386 Major Gene (NEG): PDE6A Weight Factor: 1.21

NEG ALL Major Gene (NEG): PDE6A Weight Factor: 1.454 Major Gene (BCR/ABL): BMP6 Weight Factor: 1.006



ZNF211

CSNK1E

●

● TAL1

PTPRM

●

ITGAE●

● RGS1 POLR2A ●

●

BRE GABRP ● ZFP161

●

APEX1●

●

PDE6A

●

●

ARHGEF6 KDR

RGL2SYT17

●

●

● BMP6 GOLGA1

●

WNT2

● SFRP4

●

●

RGS16

●

CD36

● MMP13

●

●

IL7

●

●

RGS1

● PTEN ●

CD83 MAST1 PON1 ● PLXNA2 ● ● CSRP2

● ●PDGFRB ●

●

RYBP

YTHDC2●

NCOA1

ITGAE CD83

● TAL1MMP13

●

●

PTPRM

●

PDE6A

●

●

●

PLXNA2

●

●

CSRP2 RGS16 BRE

●

CSNK1E

RYBP

POLR2A ZNF211

●

●

●

GOLGA1 ZFP161 YTHDC2 APEX1 SFRP4 MAST1

●

●

BMP6

● WNT2

●

● ● ●NCOA1

ARHGEF6

● PON1

RGL2PTEN ● SYT17 ● ● KDR● ● ● ● GABRP PDGFRB CD36 ● ● ●

IL7

●

Pathway: XU_GH1_AUTOCRINE_TARGETS_DN There are 84 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): DYRK1B Weight Factor: 1.385 Major Gene (NEG): TNFRSF4 Weight Factor: 1.045

NEG ALL Major Gene (NEG): TNFRSF4 Weight Factor: 1.554 Major Gene (BCR/ABL): DYRK1B Weight Factor: 1.512



NRCAM KIAA0101 ● SDHA ● HSPA1B ● CIT CD44 PCCB ● ● ADIPOR2 EFNA5 ● XIST CUX1 ● NFYC MAP3K1GPX4TNFRSF4 RELN ●● ● ● PODXL ● IPO7 PPIP5K2 ST3GAL2 CA2 ● ● ●HSPH1 ●GP9 ●NDUFB8 ● ● ●EXOC3 TNNT3 SLK ● ● ● JAK1 EFNB2 OLFM1 PXDN TMSB4X RHOQ DYRK1B● PLA2G16 TIMP3 TPM1LAMA5 ● ● ● ●●SCGB2A1 ● ● ● FAM102A ● GSTM3 ● ●DBN1 MAGED2 ●● ●SETD2 CDC42BPA ● ZNF217 ● KCNK2 ● ● ● ADCY1 SULF1 ● PIK3CA● NAT1 PLK2 TJP1● RBPMS PRLR ● TGIF2 ●SEMA3C ●RPS6KB1 ● ● ● ● EIF5 ● ● ● NR2F2 UGDH UBL3 ULK1 DSCAM ● B4GALT1 ● ●MCF2L PTPN3 ● ● CTNND2 ●● ● ● IGFBP4 NUMA1 ● ARID5B SERPINA5 THBS1 ● KDM5B AGR2 ELOVL2 RSL1D1 ● REL ● ●RAB31 ● BAMBI ● ● ● TSPYL5 ● ● ● ● RAMP1 FAM134B ● ● ● PTPRK

●

●

●

PXDN FAM102A ● LAMA5 ●ARID5B NUMA1 IGFBP4 ● ADIPOR2 EFNA5 TMSB4X SDHA GSTM3 TGIF2 ● ● ● ZNF217 JAK1 ● ●TNNT3 MAP3K1 XIST GP9 UBL3 ● ● ● ● TNFRSF4 DBN1 ● HSPA1B ●TIMP3 ● ●TJP1● ST3GAL2 ● ● ●ULK1PLK2PODXL NAT1 THBS1 ● ● SULF1 ● DSCAM ● ● CD44 CUX1 PIK3CA ● ● ●AGR2 ●KDM5B SETD2 ● PPIP5K2 ● RSL1D1 ● PRLR EIF5●HSPH1 DYRK1B SLK ● B4GALT1●BAMBI ● ●PTPRK RPS6KB1 ● GPX4 ● ●● SCGB2A1 ● ● ● ● ● MAGED2 RELN PLA2G16 ●NRCAM RBPMS ● ● ELOVL2 ●KCNK2 NDUFB8 ● ADCY1 NFYC RAB31 EFNB2 ● ● ● RAMP1 ● ● ● ● CDC42BPA ● ●MCF2L OLFM1 ●● ● ● UGDH IPO7 RHOQ ● ● TSPYL5 ● REL ●FAM134B ● PCCB ● ●CTNND2 ● SERPINA5 PTPN3 ● ● NR2F2 ● SEMA3C● ● CIT KIAA0101 EXOC3 ●

●

●

●

CA2 TPM1

●

●

●

Pathway: MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5 There are 19 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): TARS Weight Factor: 1.162 Major Gene (NEG): TARS Weight Factor: 1.162

NEG ALL Major Gene (NEG): TARS Weight Factor: 1.372 Major Gene (BCR/ABL): TARS Weight Factor: 1.372



EIF2C2

XBP1

●

ME1

●

●

● LAD1

●

IFIT1

MLH1

●

●

● PCBP2

ADK

PSMB5

●

SMPD1

●

STC2

●

●

●

ME1 ADK

TARS

ACADS BTF3

●

● TARS

● ●

INPP5A

● ACADS

FUS

●

STC2

●

XPOT

●

PSMB5

●

LAD1

MLH1

●

● XBP1

● PCBP2

●

INPP5A

● ATF4

●

●

CKS1B

●

FUS

●

SMPD1

●

CKS1B

●

●

●

EIF2C2

XPOT

BTF3

ATF4

●

● IFIT1

●

Pathway: CUI_TCF21_TARGETS_UP There are 29 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): COL6A1 Weight Factor: 1.271 Major Gene (NEG): COL6A2 Weight Factor: 1.249

NEG ALL Major Gene (NEG): COL6A2 Weight Factor: 1.394 Major Gene (BCR/ABL): COL6A1 Weight Factor: 1.366



RBP1

●

CCND2

FAP

EMID1

●

●

●

●

● CYP7B1

CADM1

●

●

● FAP

●

●

●

VCAN LHFPL2

●

MEG3 PTN ISLR ● LBP ●

● ●

CCND2 SERPINF1 ●

HMMR

PHGDH

●

●

● EPHA4

●

PENK COL3A1

●

COL6A2 CLDN9 SERPINF1 CDKN1B

●

●

CLDN9

CDH6

●

LHFPL2

LUM

HOMER2 MDK●

● HMMR COL6A1● ●

MDK

●

●

●

SOX11

●

●

CDKN1B IGFBP2 COL6A2 NCAM1

●

IGFBP2

VCAN

●

COL3A1

●

●

COL6A1 ●

PENK

LUM

●

●

●

HOMER2 MEG3 ● ● ISLREMID1 PHGDHNCAM1

● ● CADM1 ● RBP1 ● CYP7B1 ● ● LBP EPHA4 ● PTN ● ● ● SOX11 CDH6 ● ●

●

Pathway: ABE_VEGFA_TARGETS_30MIN There are 20 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PCDH17 Weight Factor: 1.444 Major Gene (NEG): MYO7A Weight Factor: 0.812

NEG ALL Major Gene (NEG): MYO7A Weight Factor: 1.274 Major Gene (BCR/ABL): PCDH17 Weight Factor: 0.577



DBC1

EGR2

●

● DUSP5

TRIB1

●

●

PPY

●

ALAD

●

PCDH17

●

HDC

●

● TKTL1

●

● DUSP5 NR4A1

●

EGR3

●

RCAN1

●

TRIB1

● DBC1

●

CYR61 CD1B

CYR61 SCRN1

MYO7A

●

● ●

EGR2

●

●

C2

C2

●

●

MYO7A

PPY

TAC1 TAC1

●

● ●

●

CD1B

●

●

●

●

● VARS

NR4A1

APOE

ALAD

APOE

●

EGR3

●

SCRN1

●

VARS

TKTL1

●

● PCDH17 HDC

●

RCAN1

●

●

Pathway: KEGG_CITRATE_CYCLE_TCA_CYCLE There are 28 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): FH Weight Factor: 1.317 Major Gene (NEG): MDH1 Weight Factor: 1.267

NEG ALL Major Gene (NEG): MDH1 Weight Factor: 1.426 Major Gene (BCR/ABL): FH Weight Factor: 1.298



SDHB

IDH3G

● DLD

●

CS

●

●

PC

●

●

PDHB SUCLA2

●

IDH1

●

● ●

●

●

●

● ● DLD

●

SDHA PDHA1

●

● PC DLST ● PDHA2 ● MDH1

ACLY

●

FH ● PDHB● ● SDHC ●

SUCLA2 SDHD

SDHC

MDH2 SDHD● PDHA1

●

●

MDH1 FH

●

●

DLAT

●

● IDH1

IDH3A

ACLY

DLAT

●

●

●

● PCK2

●

SDHA

PDHA2 DLST

PCK1

ACO1

●

IDH2

●

ACO2 IDH3G IDH3B

●

ACO1

●

●

●

●

●

●

SDHB PCK1

SUCLG2

IDH2OGDH

●

●

●

● ACO2 ● ●

PCK2

SUCLG2

IDH3A IDH3B

MDH2

●

●

CS

●

OGDH

●

Pathway: KEGG_RNA_POLYMERASE There are 17 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): POLR2L Weight Factor: 1.384 Major Gene (NEG): POLR2E Weight Factor: 1.161

NEG ALL Major Gene (NEG): POLR2E Weight Factor: 1.307 Major Gene (BCR/ABL): POLR2L Weight Factor: 1.15



POLR2A

POLR3D POLR2K

●

● POLR2J

POLR2D

POLR2B POLR3D

●

●

●

POLR3G

●

● POLR2C

POLR3F

● POLR2J

●

●

POLR2H

● POLR2F

●

POLR2L

●

POLR2L POLR2I

●

POLR2E●

●

POLR3F POLR1C

POLR2E

●

POLR2I

POLR2D

●

●

POLR3C POLR1C

●

●

●

●

POLR2B

●

●

POLR2K POLR2F

●

POLR2H

● POLR3C

●

●

POLR2A

POLR2G

●

● POLR3G

POLR2G

POLR2C

●

●

●

Pathway: KEGG_PROTEASOME There are 41 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.251 Major Gene (NEG): PSMB4 Weight Factor: 0.951

NEG ALL Major Gene (NEG): PSMB4 Weight Factor: 1.305 Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.232



PSMF1

IFNG

●

PSMF1 PSMC2● PSMD7

PSMC6 ● PSMD6

●

●

PSMA5 SHFM1 PSMD1 ● ● PSMA3 PSMD14 ●

●

●

●

●

●

PSMB2 PSMA2 PSME3

●

●

PSMD13 PSMD12 PSMD4 PSME2

PSMC1 ●

●PSMB10 ●

●

●

●

●

●

●

PSMC1 PSME4 ●

PSMD1

●

●

PSME3

● PSMA4

PSMD14 PSMA5

●

● ●

PSMA6

● PSMB2 PSMB5 ● ●

IFNG PSMB6 ● PSMD8 ● PSMD13 PSMD3 PSMA7 ●

●

PSMD2

●

●

PSMA3

PSMB7

●

PSMD11

PSMB3 PSMC5 PSMB4● ● PSMB7 PSMD8PSMC3 ● PSMB6 ● ● PSME1 ● ● ● ● PSMD3 PSMD2 ●

● PSMA7

●

PSMD7

● ● PSMC2 SHFM1 PSMA1 ● PSMB1 ● ● PSMD6 PSMA2 PSMB4

PSMA6

PSMA4

●

●

●

● PSMA1 PSME4 PSMB8 PSMC4 ● ● ● PSMB9 ● PSMB5 PSMD11 ● ● PSMB1

PSMD12 PSMC6

●

● ● PSMC3 ● PSMB3 PSME1 ● ● ● PSMB10 ● PSMD4 PSMB9 PSMC5 ● ● PSME2 ● ● PSMB8 ● ● PSMC4

Pathway: KEGG_PROSTATE_CANCER There are 82 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): INS Weight Factor: 1.524 Major Gene (NEG): KLK3 Weight Factor: 1.511

NEG ALL Major Gene (NEG): KLK3 Weight Factor: 1.559 Major Gene (BCR/ABL): INS Weight Factor: 1.499



CTNNB1PDGFA ● ●SRD5A2 ● CREB1 ● RAF1 ● FGFR2 GSK3B E2F3 CCNE2 ● NRAS AKT2 CREB3L1 ●PDGFB ● ● ● ●CDKN1B BAD ● ● CREB3L2 ● ● RELA ● E2F2 ● IKBKB TGFA NKX3−1 ●EGF KLK3IKBKG ● ●CDK2 ARAF●IGF1R ● GRB2 PDPK1 CASP9 ● E2F1 ● ● INS AR ● ● ●● ●PIK3R2 ● MAPK1 PIK3CG ● ●FGFR1 ● CHUK ● SOS1 MAP2K2 ● ● ● ● PIK3CB AKT1 ● ● PDGFRB CREB5 ● PTEN CREB3 MAPK3 AKT3 RB1 ● ● MTOR ● ● BCL2 ● NFKBIA ● ● ● ● HRAS SOS2 BRAF ● CCNE1● GSTP1 CREBBP PIK3R3 PIK3R1 KRAS ● ● ● ● ● ● TP53 PIK3CA EGFR ● ● CCND1TCF7 ● ● PDGFRA MDM2 HSP90B1 ● TCF7L2● ● ● CDKN1A ● ● EP300 PIK3CD FOXO1 IGF1● ATF4 ●● NFKB1 ● ● ● ● MAP2K1 ● ● ERBB2 ● ● LEF1 HSP90AB1 HSP90AA1

●

●

AKT3 HSP90AB1 EGFR ●IGF1 ● ● CREB5CCNE1 FGFR1 ● TGFA PIK3CB ● ● CDK2 ● PDGFA CCNE2 ● MTOR IKBKB NKX3−1 ●PDGFRB SOS1 ● PIK3R3 CREB3L1 CASP9 ● MAP2K1 ● ● ● ● PIK3CD PDGFB ● ● HSP90AA1 ● ● ● PDPK1 ERBB2 ● EGF NRASPDGFRA RELA PIK3CG FGFR2 ● ● GRB2 BCL2 CCND1 ● ● CDKN1A ● INSRB1 ● ●PTEN ●RAF1 ● ● BAD● CREB1 NFKBIA ●CREB3 ● ● KLK3TP53 AR ● ● ● CDKN1B ● ● SRD5A2GSK3B ● ●AKT2 ● ● ● E2F2 CTNNB1 ● ● ● PIK3R2 AKT1● MAPK3 ● ● ● ● ATF4 MAPK1 ● ● ARAF E2F3 MAP2K2 MDM2 ● E2F1 BRAF ● ● ●PIK3CA HSP90B1 HRAS PIK3R1 ● ● ● ● ● TCF7L2 SOS2CREB3L2 CHUK ● ● ● ●GSTP1 LEF1 IKBKG ● IGF1R ● ●CREBBP●EP300 ● ● ● FOXO1KRAS ● ● ●● TCF7 NFKB1● ●

●

Pathway: KEGG_MELANOMA There are 58 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): ARAF Weight Factor: 1.468 Major Gene (NEG): BAD Weight Factor: 1.231

NEG ALL Major Gene (NEG): BAD Weight Factor: 1.47 Major Gene (BCR/ABL): ARAF Weight Factor: 1.214



MAPK3

EGFR

● IGF1RMITF FGF5 ● ● FGF2IGF1 ● CDH1 PIK3R1 ●PIK3R3 ● CDKN1A RB1 ● FGF12 PIK3CA ● HGF ● ● ● AKT3 ●PIK3CB FGF9 ● MET ● ● ● BRAF TP53 ● RAF1 ● MAPK1 CDK4 FGF1 ● ● AKT1KRAS ● MDM2 ●

● ●HRAS CDKN2A

●

●

●

PDGFB ● MAP2K1 PDGFA ● ● FGF7 ● PDGFRA ● ● MAP2K2 ARAF ● PIK3R2 CDK6 ● PIK3CD ●BAD ● PTEN ● FGFR1 ● EGF ● ● ● E2F3 ● MAPK3PIK3CG FGF3 E2F1 ● CCND1 ● ● FGF13 ●E2F2 ● ● ● AKT2 ● FGF8 PDGFRB ● ● FGF6 FGF18 FGF4 NRAS

●

● ● ● ●

●

MDM2 PIK3R3 RB1 PIK3CB MAPK1 ● ● ● E2F1 PIK3CA ● ● MAP2K2 ● PIK3R2● CDK6KRAS IGF1 E2F2 ●TP53● HGF ● AKT1 ● ● EGFR ● ● EGF ● HRAS ●FGF3 ● ● PDGFBBAD CDK4 AKT3 FGF2 FGF5 ● ●FGF13 ● NRAS MET FGF1 ARAF ● ● ● ● ● MITF ● PIK3R1 ● ● E2F3 ● FGF4 ● ● FGF12 FGF6 ● ● BRAF CDH1 ● AKT2 ● ●FGF18CCND1 CDKN1A ● ● ●FGF8 ● ● PDGFRA ● RAF1MAP2K1 IGF1R PTEN PDGFRB CDKN2A FGF7 ● ● ●PIK3CD ● ● ●● ● FGFR1 ● PDGFA ● PIK3CG ● FGF9 ●

●

●

Pathway: KEGG_CHRONIC_MYELOID_LEUKEMIA There are 70 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): ARAF Weight Factor: 1.446 Major Gene (NEG): BCL2L1 Weight Factor: 1.406

NEG ALL Major Gene (NEG): BCL2L1 Weight Factor: 1.469 Major Gene (BCR/ABL): ARAF Weight Factor: 1.201



PIK3R3 PIK3CB ABL1 ● AKT3 STAT5A

●

● SHC1 ● PIK3R1 ● PIK3CG RUNX1 NFKB1 ● SMAD3 MAPK3 CDKN1A ● ● ● ● GAB2 E2F3● CHUK ● ●● CRKL TGFBR2 PIK3CA CDK6 NFKBIA ● ● CBLB SOS2 E2F1 ● ● ● BRAF● CDK4 KRAS● ● PIK3R2 ● ●SHC2 PTPN11 ● MDM2 ● HDAC2 RB1 TGFB3 ● ● TGFB2 ● ● MAP2K1 ● SMAD4 TP53 HRAS TGFBR1 ● ● ● ● ● CTBP1 CTBP2 PIK3CD ●AKT1 SOS1 ● BCR ● ● RAF1 ● MAP2K2 ● ● MAPK1 ● ● ● ● IKBKGARAF STAT5B MYC ● ● ●CDKN2A HDAC1 ● ● CCND1● E2F2 ● MECOM●BAD BCL2L1 ● CRK CDKN1B ● ●● NRAS SHC3 ●IKBKB GRB2 ●● AKT2 ● RELA ● ● CBL ● ● TGFB1 ● ● ●

E2F1 ARAF GRB2 TGFB2 CTBP1 PIK3CG CRKE2F2 ● HDAC1 ● ● IKBKG ● TGFB3 ● ● PIK3CD ● AKT1 ● MECOM ● CTBP2 ●AKT3 CDKN2A ● HRAS BCL2L1 ● TP53 ● CRKL SOS1 ● MAP2K2 ● ● BRAF● SHC3 ● NFKBIA PTPN11 ● ●CCND1 ● ● AKT2 RAF1 ● ● MYC ● ● NRAS BAD ● BCR SMAD4 E2F3 ● RELA CDKN1A ● ●PIK3R2 ● SMAD3 ● MAP2K1 HDAC2 ● ● ● CDK4 ● SHC1 ● ● ● ● ● SHC2 PIK3R3 ● STAT5B CBL CDKN1B ● ● TGFB1 SOS2 TGFBR1 ●IKBKB KRAS ● ● ● CHUK ● RUNX1 ● CBLB ●PIK3CA ● TGFBR2● ● RB1● PIK3CB ● PIK3R1 ● CDK6 ● NFKB1 MDM2 ● ● ● GAB2● ● ● MAPK1 ● STAT5A ABL1

●

●

●

MAPK3

●

●

Pathway: BIOCARTA_AKT_PATHWAY There are 22 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PDPK1 Weight Factor: 1.359 Major Gene (NEG): PPP2CA Weight Factor: 1.19

NEG ALL Major Gene (NEG): PPP2CA Weight Factor: 1.269 Major Gene (BCR/ABL): PDPK1 Weight Factor: 1.259



CASP9 GHR PIK3CG

●

●

●

●

PDPK1 ● CHUK

●

HSP90AA1

●

IKBKG

● GH1

●

●

FOXO3

●

PIK3CA

● PIK3R1

●

NFKB1●

BAD PPP2CA

● FOXO1

●

PIK3CG CASP9 NFKBIA

●

IKBKB

●

●

●

●

●

● GH1

●

●

RELA

● PDPK1

FOXO1

● NFKB1

CHUK

●

●

PIK3R1

●

AKT1

● ●

FASLG

HSP90AA1 PIK3CA

●

NFKBIA

●

PPP2CA

YWHAH

●

RELA IKBKB

●

●

FASLG YWHAH●

BAD

● FOXO4

GHR

●

FOXO4

AKT1

●

●

IKBKG FOXO3 ● ●

Pathway: BIOCARTA_BCELLSURVIVAL_PATHWAY There are 16 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PIK3CA Weight Factor: 1.483 Major Gene (NEG): ZBTB7A Weight Factor: 0.961

NEG ALL Major Gene (NEG): ZBTB7A Weight Factor: 1.478 Major Gene (BCR/ABL): PIK3CA Weight Factor: 0.927



CASP3

FOS

●

PIK3R1

●

●

JUND

●

●

PIK3R1 PIK3CA

BIRC5

●

●

●

●

BIRC5

●

FOS

● ITGB1 ZBTB7A

●

CASP3

●

ITGA1

● ITGA1

CASP7

● ●

DPF2

●

CCT4

●

CCT4

AKT1

●

ZBTB7A

●

●

● ITGB1

XIAP

●

●

DPF2

●

MTOR

●

PIK3CA

●

AKT1

PIK3CG

●

JUND

●

CASP7

PIK3CG

● XIAP

●

MTOR

●

Pathway: BIOCARTA_NTHI_PATHWAY There are 24 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): SMAD3 Weight Factor: 1.37 Major Gene (NEG): RELA Weight Factor: 0.749

NEG ALL Major Gene (NEG): RELA Weight Factor: 1.318 Major Gene (BCR/ABL): SMAD3 Weight Factor: 0.637



TGFBR1 MAP2K6

●

●

NR3C1

● DUSP1

SMAD4

●

●

CREBBP ● TGFBR2

MYD88 MAP3K14

●

●

MYD88

TNF

●

●

●

●

● ●

●

NFKB1

● IL8

●

NFKBIA

TLR2

● ● MAPK14 IKBKB ● ●

●

TNF

● CHUK

●

● NFKB1

● ●

MAP3K7

CREBBP

●

● IKBKB MAPK11

MAP2K3 TGFBR1

● MAP2K6 ●

IL1B

●

●

MAP3K7

● RELA

SMAD4

● TGFBR2

SMAD3 EP300

IL1B MAPK11

●

CHUK EP300 ●

IL8

● MAP2K3

●

●

●

●

NR3C1

TLR2

NFKBIA SMAD3

●

●

DUSP1

RELA ● ●

MAPK14 MAP3K14

●

●

Pathway: BIOCARTA_MITOCHONDRIA_PATHWAY There are 20 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CASP8 Weight Factor: 1.341 Major Gene (NEG): ENDOG Weight Factor: 1.042

NEG ALL Major Gene (NEG): ENDOG Weight Factor: 1.399 Major Gene (BCR/ABL): CASP8 Weight Factor: 1.147



CASP9 BIK

CASP3

●

●

● BAX

BCL2L1

●

● DFFA AIFM1

CASP6 ENDOG ● ●

●

XIAP CASP7

CASP8

BIRC2

●

●

BCL2

●

BIRC3

●

DFFB

●

CASP3

●

●

CASP8

●

XIAP

●

BID

●

BIRC3

●

●

BAK1

BCL2

ENDOG AIFM1 CYCS ● BIRC2

●

●

●

●

BAX BID

●

BAK1

●

DFFA

●

●

CASP9

●

●

BCL2L1 CASP6

●

●

CYCS

●

DFFB

●

●

●

APAF1

●

●

CASP7

APAF1

BIK

●

Pathway: BIOCARTA_TEL_PATHWAY There are 18 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): KRAS Weight Factor: 1.289 Major Gene (NEG): TEP1 Weight Factor: 0.943

NEG ALL Major Gene (NEG): TEP1 Weight Factor: 1.419 Major Gene (BCR/ABL): KRAS Weight Factor: 1.038



PRKCA

BCL2

●

● MYC

AKT1

● KRAS ●

RB1

●

PRKCA

●

TNKS

●

●

EGFR

XRCC6

●

●

●

TERT

●

POLR2A HSP90AA1

PPP2CA

●

●

HSP90AA1

POLR2A

●

●

AKT1

● KRAS

●

● XRCC5

●

TP53

●

TEP1 TERF1

●

●

RB1

●

BCL2

●

EGFR

●

TEP1

PPP2CA

●

●

●

●

●

XRCC5

MYC

XRCC6

●

●

●

TNKS

●

TP53

TERT IGF1R

TERF1

IGF1R

●

Pathway: BIOCARTA_TNFR2_PATHWAY There are 18 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): IKBKAP Weight Factor: 1.343 Major Gene (NEG): IKBKB Weight Factor: 1.157

NEG ALL Major Gene (NEG): IKBKB Weight Factor: 1.383 Major Gene (BCR/ABL): IKBKAP Weight Factor: 1.147



●

MAP3K14

●

●

TRAF1

IKBKB

●

● CHUK

●

TNFRSF1B

TNFRSF1B

RELA

MAP3K1

IKBKAP

●

NFKBIA TRAF2

●

TANK

●

●

NFKB1

TANK TRAF3

●

● TRAF2

NFKB1

RIPK1

●

●

DUSP1

MAP3K1

MAP3K14

●

●

TRAF3

IKBKG

●

● TRAF1

●

LTA

●

●

TNFAIP3

●

RIPK1

RELA

● ●

IKBKG

●

●

IKBKB

CHUK

●

● ●

●

● TNFAIP3

NFKBIA

LTA

IKBKAP

●

●

●

●

DUSP1

●

Pathway: BIOCARTA_TOLL_PATHWAY There are 30 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): RELA Weight Factor: 1.326 Major Gene (NEG): PGLYRP1 Weight Factor: 1.274

NEG ALL Major Gene (NEG): PGLYRP1 Weight Factor: 1.496 Major Gene (BCR/ABL): RELA Weight Factor: 1.451



NFKBIA

FOS

TAB1

● IKBKG TAB1 PGLYRP1

●

●

●

MAP3K1 TLR2

● ● MAPK14

●

RELA ●

●

CD14 MAP2K3 MAP2K6 ●IRAK1 ●

●

●

●

MAP2K4

●

●

●

●

TRAF6

●

MYD88 ● CHUK

EIF2AK2

● NFKB1 ● NFKBIA ● PPARA ● ●

LY96

● MYD88

●

●

TAB2

MAP3K14

●

● ●

●

ELK1

MAP2K6

●

PPARA NFKB1 ● LY96

●

TLR6

●

●

MAP2K3

FOS TRAF6

●

●

●

MAPK14MAPK8

RELA

MAP2K4

●

TLR2

●

IRAK1

TLR6

IKBKB

JUN

●

MAP3K7 ELK1

● TLR3

MAPK8

CHUKJUN

● ●

●

●

EIF2AK2

● PGLYRP1● ● MAP3K7 MAP3K1 IKBKB ● TLR3 ●

●

CD14 TAB2 ●

●

●

●

MAP3K14

●

IKBKG

●

Pathway: REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC There are 51 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.312 Major Gene (NEG): PSMB4 Weight Factor: 0.989

NEG ALL Major Gene (NEG): PSMB4 Weight Factor: 1.343 Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.295



CDC16 ANAPC5 PSMA7PSMD2 ● PSMD3

●

● ●

●

PSMA2

● UBE2C PSMB2 UBE2D1 PSME2PSME3 PSMB3 PSMC5 ● PSMA6 PSMC3 PSMB6● ● ● ● ● ● PSMD5 ● ● PSMB10 ●PSMD4 PSMD8 PSME1 PSMA4 ●PSMD14 ● ● PSMB5PSMB9PSMA3 PSMD1 ● ● PSMD13 ● ● ● PSMA5 PSMB7 ● ●PSMD9 ●PSMB8 FZR1 ● ● ● PSMF1 ● PSMC1 ● ● PSMD12 PSMD10 PSMB4 ● PSMB1 PSMD7 ● PSMC4 ● PSMA1 ● ● ● ● PSMD11● ● CDC27 CDC23 UBB ● ● ● PSMC6 PSMC2 ● PSMD6 ● ANAPC10 ● ● ● UBE2E1 ●

ANAPC5PSMC5PSMD4 PSMD11 PSMC4 ● ● UBE2D1 ● ● ● PSMD13 PSMC3 ● PSME2 PSMB10PSMB3 PSMD3 ● ● PSMB8 ● PSMB9 ● PSMD2 PSME1● PSMD8 ● PSMD5 UBE2C

●

●

●

PSMA7

●

●

PSMD9 ● PSMB6

●

●

PSMB7

●

●

PSMA6

PSMB2 ● PSMB5

●

● PSMC1 PSMB4 ●PSMA4 ● PSMA5 PSMD14 ● PSMA3 PSMA2 ● ● ● ANAPC10 ● CDC27 PSMD10 ● CDC23 PSMD6 PSME3 PSMB1 ● ● PSMD1 ● PSMD12 PSMC2 ● ● ● ● PSMA1 PSMF1● ● ● PSMC6 CDC16 ● ● ●PSMD7 UBE2E1 ● UBB ● FZR1● ● ●

Pathway: REACTOME_CD28_CO_STIMULATION There are 25 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): MAPKAP1 Weight Factor: 1.53 Major Gene (NEG): MAPKAP1 Weight Factor: 1.53

NEG ALL Major Gene (NEG): MAPKAP1 Weight Factor: 1.515 Major Gene (BCR/ABL): MAPKAP1 Weight Factor: 1.515



PIK3R1 PAK2 ● ● GRB2

FYN

● AKT3

CD86

MAP3K14

CD28

●

●

CD80

MTOR

●

● ●

● AKT1

●

●

SRC

●

●

●

●

●

GRAP2●

PDPK1

● AKT2

●

●

●

● RAC1

●

●

●

●

●

MTOR

●

PIK3CA

● VAV1

PDPK1

●

GRAP2

●

●

CDC42 MAP3K8

MAP3K14

SRC AKT2

● CDC42

MAP3K8

●

●

PAK1

PIK3CA YES1

LCK

AKT1 MAPKAP1

●

PAK1

●

●

MAPKAP1 LCK GRB2

LYN

RAC1

FYN

●

LYN

PIK3R1

VAV1

●

YES1

●

●

● PAK2

●

●

●

AKT3

●

CD80

● CD28

●

CD86

●

Pathway: REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A There are 57 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.34 Major Gene (NEG): PSMA4 Weight Factor: 1.34

NEG ALL Major Gene (NEG): PSMA4 Weight Factor: 1.321 Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.321



CDK1 CCNA2

●UBE2C ● BUB1B

PSMA7

CDC16

●

● ANAPC5 UBE2D1 PSMD2 CDC20 ● ● PSMC3 ● ● ● ● PSMC5PSMD3 PSMD5PSME3 ● PSMB3 MAD2L1 ● PSME2 ● PSMD4 ● PSMB10 ●● PSMB6 PSMA2●PSMB2 ● ● ● PSME1 ● PSMD8 PSMD13 PSMB9 ●PSMA6 ● PSMB5 PSMA4 PSMD14 ● ● ● ● ● ● PSMD1 ● PSMD9 PSMA1 ● PSMB8 ● PSMA3 PSMB4 PSMB1 ● PSMB7 ● PSMA5 ● PSMD12 PSMC1 PSMC4 ● ● ● ● ●

● PSMD10 ● ● BUB3 PSMD11 PSMF1 PSMD7 CDC27 PSMC6 ●

●

●

●

●

● ● PSMC2PSMD6 CDC23 UBB ● ● ● CCNA1 ANAPC10

●

●

BUB1B

● UBE2E1 ●

● CDK1 CCNA2 ●MAD2L1 BUB3 ANAPC10

●

● UBE2C ● PSMA3 PSMD5 ● PSME3 PSMA6PSMB5 PSMD14 ● ● ● CDC23 PSMA4 CDC16 ● ● ● PSMD3 ● ● PSMB2PSMA5 ● PSMD13 CDC20 ● CCNA1 ● PSMD1 PSMD10 UBE2D1 ●● ●PSMD8 ● ● ● PSMF1 ● CDC27 ● PSMD4 PSMC3 ● ● PSMD7 PSMD12 PSMD9 PSMC4 ● PSMB6 PSMB4 ● ● PSMB3 ● ● PSMC5 ● ● ● ● PSMC2 PSMC6 ● PSMD11 PSMB7 PSMD2 PSMB1 ● PSMB10 PSMA2 ● ● PSME1 ANAPC5 PSMA1 ● ● PSMC1 UBE2E1 ● ● ● PSMA7 ● ● PSMD6 ● PSME2 ● ●UBB PSMB9 ● ●● PSMB8 ●

●

●

●

Pathway: REACTOME_CELL_CYCLE_CHECKPOINTS There are 91 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.393 Major Gene (NEG): MCM6 Weight Factor: 1.155

NEG ALL Major Gene (NEG): MCM6 Weight Factor: 1.427 Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.304



RAD1 PSMB5 ●

PSMD12 PSMD9 ● ● CDC27 PSMD3 PSMB9 PSMA3 ● PSMB10 PSME1 PSMA7PSMD2 PSMB8 ● PSMD11 PSMD13 ● ●● ●PSMC4 PSMB6 PSMD8 ● ● MAD1L1 RFC2● PSMD4 ● PSMB3 PSMB7 ●PSMC5 ● ● UBE2E1 ● ● PSMB4 ANAPC10 ● PSMC3 ● ● CDC20 PSMC1 ● ● MCM4 PSMA4 PSMD6 CDC25C ● ● ● RFC5 PSMB2 UBE2D1 MCM5 ●● ● PSMA2 PSMB1 PSME2 ● ● ●● PSMA6 ● ● TP53 PSMD5 ● PSMD14 PSMD10 ● ●● ● ● PSMA5 ● MCM3 BUB3 CHEK1 ● ●HUS1 PSMD7 RAD9A ANAPC5 ● ● ATM ● RPA1 ● ● RPA2 PSMD1PSMC2 ●PSMA1 ● ●● ● ●● ● MAD2L1 MCM7 RPA3 ● ● UBB WEE1 ● ●PSMF1 MDM2 CDK2 PSMC6 DBF4 MCM2 ● ● MCM6 ● ● RFC4 ● ●● PSME3 ● ● CCNE2 CHEK2 ● ATR CCNB2 ● ● CDK1 UBE2C ●●● RAD17 ● CCNB1 CDC7 ● CDC6 CDC16 CDC25A CDKN1A ● ● BUB1B CCNE1 ● ● ●● ● ●● ● RFC3 ● CDC23

● ●

PSMD11 PSMC5 ● PSMD2 PSMC4 UBE2D1 ●PSMD4 RAD9A ● MAD1L1 ● PSMC1 HUS1 MDM2 ●PSME1 PSMB3 ●PSMD13 ● CDC25C CDC25A PSMC3 DBF4 ● ● PSMD8 ● ● PSMD6 ● ● PSMB10 ●RFC2 PSME2 ● PSMD3 PSMB6PSMC2 RAD1 ●PSMA7 ● ● PSMB9 ● PSMA1 ●PSMC6 ● ● PSMB8 MCM4 PSMB7 UBE2E1 ● PSMB1 ● ●● ● ANAPC5 ● PSMD9 ● PSMA2 ● CDC20 ATM ● ● ●PSMD5 ● RAD17 ●● PSMD12 ● ● ● MCM5 ● TP53 PSMB4 CDKN1A CDC27 ● ● ●RPA1 ● PSME3CDC16● ●●● ● ● PSMD7 ATR PSMD10 ● ● ● MCM3 UBE2C ● MCM7 ● UBB PSMD1 ● ●● MCM2 ● CDK2 PSMA5 CCNE1 PSMF1 CHEK2 ● WEE1 ● MCM6 PSMD14 CDC23 CCNE2 ● CDC6 ●RFC3 ● ● CCNB2 ● ● PSMA6 CDC7 ●MAD2L1 ● BUB1B ● ● ● ● PSMB5 RFC4 PSMA4 ●PSMA3 ● ● CDK1 ● BUB3 ANAPC10 ● RFC5 PSMB2 CCNB1 RPA3 ●● ● ● ● ● ● ● ● ● ●CHEK1 RPA2

● ●

Pathway: REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING There are 28 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): CCT3 Weight Factor: 1.458 Major Gene (NEG): CCT5 Weight Factor: 1.397

NEG ALL Major Gene (NEG): CCT5 Weight Factor: 1.36 Major Gene (BCR/ABL): CCT3 Weight Factor: 1.263



USP11

TUBB2B

●

●

TUBA1B

ACTBSKIV2L

CCT5

NOP56 ● CCT4 TUBA3D CCT3 ●

PFDN6●

●

TUBA4A

● VBP1

●

●

●

CCT6A CCT8 PFDN1 ● ●

● TUBB2A LONP2

●

TCP1

●

●

CCT3 CCT4

●

KIFC3

● CCT6A

●

PFDN1

●

●

TUBA1B FKBP9 TCP1 ● CCT2

NOP56 VBP1

●

●

●

CCT5

●

●

●

ARFGEF2

●

●

FKBP9

●

●

KIFC3

FBXL5 TUBA4A ● LONP2 TUBB2B ● ● ●

TUBA3D TUBB2A

●

SKIV2L CCT7

CCT2

●

USP11

●

● ●

●

●

●

●

FBXL5 TUBB3

ACTB

PFDN6 TUBB3

●

● CCT7

● PFDN4PFDN5

●

●

●

● ARFGEF2 ●

PFDN5

●

PFDN4

CCT8 ● ●

Pathway: REACTOME_CITRIC_ACID_CYCLE There are 18 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): IDH2 Weight Factor: 1.263 Major Gene (NEG): NNT Weight Factor: 1.124

NEG ALL Major Gene (NEG): NNT Weight Factor: 1.306 Major Gene (BCR/ABL): IDH2 Weight Factor: 0.482



ACO2

MDH2 IDH3A ●

DLD

●

●

IDH3B

●

SDHC

●

FH

●

IDH3G

● ●

●

NNT

IDH2

●

●

OGDH

DLST

●

● SDHB

●

●

IDH2

●

●

●

SDHB

SDHA

CS

●

● ●

● ●

SDHC

● FH

IDH3A

CS

NNT

●

SDHD

●

●

●

●

OGDH

SDHD

SDHA

●

SUCLG2 DLD

●

IDH3B

ACO2

IDH3G

SUCLA2

●

SUCLA2

SUCLG2

●

●

DLST

●

MDH2

●

Pathway: REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ There are 58 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMB6 Weight Factor: 1.363 Major Gene (NEG): PSMB4 Weight Factor: 1.018

NEG ALL Major Gene (NEG): PSMB4 Weight Factor: 1.365 Major Gene (BCR/ABL): PSMB6 Weight Factor: 1.214



SKP1 ● PSMD3 PSMD9 ● PSMD2 CCNA2 SKP2 ● PSMB6 PSMC5

●

●

●

PSMD12 CUL1 ●PSMB3 ● PSME3 ● PSMA7 CKS1B ● ● PSMB10 PSME2 ● CCNE1 PSME1 ●PSMD8 ● ● CCNH ● PSMB9 ● ● ● PSMB5 ●PSMD4 ● PSMA2 PSMB2 PSMA3 PSMB7 ● PSMD1 ● PSMA4 PSMA5 MNAT1 ●● PSMC3 ● PSMB8 PSMD14 ● PSMC1 PSMB4 ● ● ● PSMD13 ● ● ● PSMA6 ● PSMD7 ● ● PSMB1 PSMD5 ● ● PSMD10● PSMC4RB1 PSMD11 ● ● PSMF1 ● ● ● CCNA1 ● CDK2 CCNE2 ● PSMA1 PSMD6 ● CDK7 ● CDKN1A WEE1 ● ● UBB PSMC2 ● ●PSMC6 ● ●CDC25A ● ● ●

●

PSMC5 ●PSMD4 PSMB8PSME2 CDC25A PSMB9 ● PSMB10 ● ● PSMC3 ● PSMB3 PSMD2 PSME1 ● ● ● ● PSMD13 ● ● PSMA7 PSMC4 PSMC1 PSMD8 ● ● ● PSMD3 PSMD9 PSMB6 PSMD11SKP2 ● ● CDK7 CDKN1A PSMB7 ● ● ● CCNA1 ● ● ● PSMD6 SKP1 MNAT1 ● ● PSMD5 PSMA2 PSMA1 PSMB4 ● PSMB1 ●PSMC2 ● ● ● ● ● ● PSMB2 ●PSMC6 ● PSMF1 RB1 CDK2 ● ● UBB PSMA6 ● CCNE2 ●PSMD12 ● PSMA4 PSMA5● ● PSMD7 WEE1● PSMA3 PSMD1 ● ●PSMD14 ● PSMB5 CKS1B PSMD10 ● ● ● ● PSME3 ● ● ● ● CUL1 CCNH CCNE1 ● ● ● CCNA2

●

●

Pathway: REACTOME_DOUBLE_STRAND_BREAK_REPAIR There are 20 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): RPA2 Weight Factor: 1.342 Major Gene (NEG): RPA2 Weight Factor: 1.342

NEG ALL Major Gene (NEG): RPA2 Weight Factor: 1.35 Major Gene (BCR/ABL): RPA2 Weight Factor: 1.35



XRCC6

RAD51

● LIG1 BRCA1

RPA1

●

● RAD50

●

RPA2

H2AFX

●

PRKDC

LIG1

MRE11A

●

RPA1 ATM

●

●

● XRCC6 ●

MDC1 NBN

● RAD52

●

●

● XRCC4

● BRCA2

●

RAD50

● TP53BP1

●

LIG4

●

●

RAD51

●

●

XRCC5

● LIG4

MRE11A

●

ATM

PRKDC

●

RPA3 ● ●

BRCA1●

●

RAD52

●

● RPA3

●

H2AFX

XRCC5● TP53BP1 ● RPA2 ● ● MDC1 ● NBN

● XRCC4 ● BRCA2

●

Pathway: REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS There are 15 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): AGL Weight Factor: 1.323 Major Gene (NEG): PHKG1 Weight Factor: 0.885

NEG ALL Major Gene (NEG): PHKG1 Weight Factor: 1.374 Major Gene (BCR/ABL): AGL Weight Factor: 1.013



PHKA1

PYGM

●

●

PGM1

●

PHKA2

CALM1

PHKG1

●

●

●

● PHKG1

●

PYGL

PHKB

●

PHKA1

●

●

PYGM

PHKA2

●

●

●

PYGL

●

●

AGL

PHKB

PGM1

●

CALM1

CALM2

●

GYG1

●

GYG1

●

●

●

PYGB

●

GYG2

PHKG2

●

PHKG2

●

AGL

●

CALM2

CALM3

●

GYG2

●

CALM3

●

PYGB

●

Pathway: REACTOME_HIV_INFECTION There are 167 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMB10 Weight Factor: 1.51 Major Gene (NEG): NUP205 Weight Factor: 0.846

NEG ALL Major Gene (NEG): NUP205 Weight Factor: 1.329 Major Gene (BCR/ABL): PSMB10 Weight Factor: 1.133



GTF2F2 WHSC2 PSMB4 SLC25A6 FYN ● PSMB1 ● ● B2MPSMB7 ●HMGA1 ● NPM1 NUP98 RAN PSMC1 ATP6V1H ● SUPT5H PSME1 SUPT4H1 HLA−A ● ● AP2B1 PSMB5 ● ● FEN1 ● PSMA1 ● ●ARF1 COBRA1 PSMA7 POLR2B ● ERCC3●TPR TAF10 ● PSMD12 ●PSMC4 PSMC6 PAK2 CDK9 ● GTF2H3 AP1S1 ● CDK7 ● POLR2E ●● POLR2D ● PSMD8 PSMB8 NUP153 ● ● ● ● GTF2E1 ● ● TCEB1 ● ● ● PSMD11 GTF2B HCK ● ● PSMD13 CCNH ●●CD247 RANBP2 ●● ● RAE1 PSMD6 XRCC4 PSMB10 POLR2J ●BANF1 ● LCK AP1G1 TAF12 RNMT SKP1 ● ● APOBEC3G PSMD2 ● NUPL1 ● TAF11 ● AP2S1 ●●PSMB9 ●TAF9 ● TAF13 PSMA3 ●PSMD9 ● ●● NCBP2 ● ●● PSMD4 ● POLR2F POLR2H NUP88 ● ● ● ● POLR2I NUP50 TAF4B GTF2H2 PSMB3 ● PSMC3 CXCR4 ● ● ● ● ● ● SLC25A5 PSMB6 ●● CCR5 ● CD28 ● ● ● ● ● PSMC2 NUP62 TCEB2 ● ● ●PSMA4 ● ● KPNA1 ●● ● ● TCEB3 POLR2K POLR2G TAF1 PSMC5 ●PSMD5 ● GTF2H4 ERCC2 BTRC ●LIG4 ●POLR2L ● TAF5 ELL GTF2A1 RANGAP1 ● XRCC6 ● ● ● PSME2 POM121 ● ●● LIG1 ● ● RDBP ● UBB ● CD8B POLR2A ● ● CUL5 ● ●CCNT1 TAF6PSMD3● PSMD7 NUP214 ●● PSMB2 ●PPIA ● ● ●● PSMD10 ● ●NUP93 AP1S2 PSMA5 ● ● SSRP1 GTF2F1 ● ● ● PSMA2 TBP NUP205 ● ● RAC1 CD4 ● ●GTF2A2 ● ● PSMF1 CTDP1 ●● ●●PSMD1 PSMA6 NUP188 ● TCEA1 ● ● PSMD14 KPNB1 SLC25A4 ● XRCC5 ● NUP210 ●RANBP1 ● TAF4 NUP160 POLR2C ● ●● ●●DOCK2 ●NUP155 AP2A2 ● ●AP1B1 MNAT1 PSME3 ●RNGTT ●PSIP1 ● AP2M1 ● ●●●GTF2H1 ● XPO1 NUP133 ● GTF2E2 ● ●ELMO1 ● ●● ●● NUPL2 NCBP1 ● ● ●

●

●

TAF11 SKP1 WHSC2 GTF2A1 MNAT1 DOCK2NUP160 ● CUL5 ATP6V1H SLC25A5 ● POLR2A ● RNMT ● CCNT1 PSIP1 ● PSMD12 ● ● POLR2K RAE1 POM121 ● PSMF1 AP1G1 ●●POLR2B RANBP2 ● ●NUP153 BTRC ●LIG4 NUPL1 NUP205 ●ELL ELMO1 ● NUP88 ● AP1S2 ● ● RAC1 CD4 ● ● GTF2H4 PSMD10 TAF4B ● ●RNGTT ● CXCR4 ● ● ● ● ●● ●TAF9 POLR2C PSMC2 ●GTF2F1●PSMC6 ● PSMD6 ● ●NUP62XPO1 NCBP1 ● ● GTF2B FYN SLC25A4● XRCC5 ● TAF1 LCK CD8B NUP155 ● ● ● ●TCEB1 ● GTF2A2 NUP214 ● ●PSMD1 TAF4 TBP PSMA3 ● ● ● TCEA1 ● AP1B1 PSMA1 ●● ● ●● ERCC2 PSME3 PSMD7 GTF2F2 ● ●●● GTF2E2 ● XRCC4 PSMA5 ● ● KPNB1 ● ● AP2A2 ●● GTF2H3 NUPL2 ● ● CD247 PSMD14 ● PSMB1 ● KPNA1 CDK7 GTF2H1 ● NUP93 POLR2H COBRA1 HCK ● PSMA6 ●UBB NUP133 ●PPIA ● ● PSMA4 ● ●B2M ● APOBEC3G AP2M1 ● ● ● ●● ●NPM1 ● ● AP1S1 ●HLA−A PSMD5 ● ● GTF2E1 NUP188 PSMA2 ● ● PAK2 ● PSMC1 PSMB2CTDP1 RANGAP1 ● LIG1 GTF2H2 RDBP●RAN ● RANBP1 PSMB4 TAF6●PSMA7 ●● ● ●PSMB8 ● ● PSMB5 CCNH ● ● FEN1 ● NCBP2 ● SSRP1 ● PSMD3 ● ● PSMB9 PSMD2 CDK9 ● ● PSMD13 SUPT4H1 ● ● ●PSMD11 PSMB10 ● POLR2J TAF12 PSMB6 ● AP2S1 ● ARF1 ● ● BANF1 ● ● ●HMGA1 ERCC3 ● POLR2G ●PSME2 POLR2I PSMC3 ●● ●PSME1 ● ● ● ●CCR5 ● PSMB7SUPT5H ●● ●SLC25A6 PSMB3 TCEB2 ● ●PSMC5 ● PSMD4 XRCC6 TPR NUP98 TAF10 ● PSMD8 ●POLR2E ● PSMC4 POLR2L ● POLR2F● ● POLR2D ● ●● NUP50 NUP210 CD28 ●● ● PSMD9 ●● ● ● ● ● AP2B1 TAF5 ● ● TCEB3 ●● ● TAF13 ●

●

●

●

●

Pathway: REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR There are 15 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): RPA2 Weight Factor: 1.327 Major Gene (NEG): RPA2 Weight Factor: 1.327

NEG ALL Major Gene (NEG): RPA2 Weight Factor: 1.318 Major Gene (BCR/ABL): RPA2 Weight Factor: 1.318



RAD50

RAD50

●

● ATM

H2AFX

●

●

RAD52

RPA3

●

RPA1

BRCA1

●

●

●

RAD51

MRE11A

RPA3

●

●

●

ATM

RPA1

NBN

●

●

● TP53BP1

●

MDC1

●

● BRCA1

● RAD51

● ●

●

●

BRCA2

NBN

MRE11A

●

RPA2

H2AFX

RAD52

BRCA2

LIG1

●

RPA2

LIG1

●

●

● TP53BP1

●

MDC1

●

●

Pathway: REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS There are 106 genes in this pathway. This pathway was detected by GSNCA





KPNB1 PSMD14 NUP93 NUPL2 ●PSMA6 PSMD5 HCK AP2A2 PSME3 ● ●PSMA5 ● ●PSMD7 CDK9 CD4 ●PSIP1 PSMD1 PSMD3 CUL5 ●PSMA7 ● AP2B1 RANBP1 ●● PPIA ●PSMB2 CCNT1 ● NUP133 ● ● LCK ● KPNA1 BTRC ● PSMD2 ● RAC1NUP210 ● NUP214 ● ● PSME2 AP1S1 PSMC5 ● ●●NUP155 ● ● ● CD28 PSMD10PSMA4 ● NUP205 ● ● ● NUP188 ●XPO1 PSMA3 PSMB6 ● PSMB3 ● ● ● PSMA2 NUP160 ● PSMD4PSMD13 ● ● ● ●PSMD9 ● ● ●● PSMC3 ● ● ●AP2M1 DOCK2 ● HLA−A NUP50 SLC25A4 PSMB8 ● ● CD8B ● ● PSMB10 PSMF1 AP1S2 TCEB2 PSMC4 NPM1 ● PSMD8 ●● SLC25A6 NUP98 SLC25A5 ●SKP1HMGA1 PSMB9 ● ● ● ● PSME1 ● ● ● ELMO1 ●● AP2S1PSMB5 ● ● ATP6V1H ● ● ● POM121 UBB ● RAN ● FYN PSMD11 AP1B1 ● APOBEC3G ● PSMB7 ● BANF1 PSMC1 CD247 ● RANBP2 ● ● ● NUP153 ● ●NUP62 ● ● PAK2 ● PSMC2NUPL1 ● B2M ● ● PSMD12 TPR AP1G1 ● ● ● ● ● PSMB4 NUP88 RAE1 ●● PSMB1 PSMD6● ● ●● PSMC6 ● ARF1 ● ● ●PSMA1 ● TCEB1 RANGAP1

● ●

●

CUL5

RANBP2

RAC1 ● PSMD12 NUP160 NUPL2 AP1G1 ●POM121 SLC25A5 RAE1 ● ATP6V1H DOCK2 NUP88 ● ● PSME3 ● SKP1 ●● PSIP1PSMD10 ● ●● NUP153 ● ●NUPL1 PSMC2 PSMD6 ● ●CCNT1 ●PSMF1 ELMO1 NUP155 NUP205 ● TCEB1●● PSMC6 CDK9 FYN ●● ● ● ● ● ● ● ● AP1B1 KPNB1 ● ARF1 ● PSMC1 PSMA7 XPO1 NUP188 UBB PSMB1 ● AP1S1 ●NUP62●CD8B BTRCCD4 ● NUP93 ● ●● PSMA1 AP2M1 PSMB9 ● SLC25A6 BANF1 ●LCK ● ● ● PSMD7 ● B2M ●CD28 ● ● PSMB10●SLC25A4 PSMD2 ● PSMC5 PSMD1 PSMB8 ● NUP214 ● ● ● ●● CD247 ● ●HMGA1 ● NUP50RANGAP1 PSME1 HLA−A PSME2 ● AP2A2 ● PSMB4 ●● PSMD4 ● PSMD13 ●PSMA6 ● TCEB2AP2S1 ● ● ● APOBEC3G PSMB3●PSMC3 KPNA1 PSMA2 ● ● ● ● PSMB6 ● ● PSMA5 ● NUP210 ●● HCK ● PSMD8 ● ●PSMC4 PSMB7 ● AP1S2 ● RAN ● PSMD3 PSMD14 ● ● PSMD9 PSMD5 PSMB2 ● ●● ● PSMA4 AP2B1 ●PAK2 NPM1● PSMA3 ● ● ● ● PSMD11 ● ● TPR ● ● PSMB5 RANBP1 PPIA NUP98 ● ● NUP133 ● ● ● ● ●

Pathway: REACTOME_PYRUVATE_METABOLISM_AND_TCA_CYCLE There are 31 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): FH Weight Factor: 1.321 Major Gene (NEG): PDHB Weight Factor: 1.01

NEG ALL Major Gene (NEG): PDHB Weight Factor: 1.389 Major Gene (BCR/ABL): FH Weight Factor: 1.315



DLST

● DLAT

●

●

OGDH

●

SDHD SDHA

●

LDHB

●

NNT PDHA1

●

●

●

●

BSG

●

ACO2

PDK1 CS ●

●

IDH2

●

FH MDH2 ● SDHC ●

●

SLC16A1

●

LDHA

●

●

IDH3A

● PDK4

●

PDK3

●

SDHC

● PDK4 SLC16A1 DLST FH ●

●

●

SUCLG2

● PDK3 ●

● NNT ●

● ●

● SDHB SUCLG2 DLD SLC16A3 ● ●

DLAT SDHD ● PDHX ● SUCLA2 ● PDHB ●

MDH2 ● SLC16A3

PDK2

●

PDHX ●

●

PDHA1

●

SUCLA2 PDHB

●

IDH3B IDH3G ●

● LDHB

SDHB

●

IDH3B IDH2●

LDHA

●

●

CS

● PDK2 ● DLD ● ●

● IDH3A

●

SDHA

PDK1

ACO2 IDH3G ● BSG ●

●

OGDH

●

hway: REACTOME_REGULATION_OF_APC_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHA There are 64 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.381 Major Gene (NEG): PSMA4 Weight Factor: 1.381

NEG ALL Major Gene (NEG): PSMA4 Weight Factor: 1.334 Major Gene (BCR/ABL): PSMA4 Weight Factor: 1.334



PSMA7

●

PSMB8

UBE2D1

ANAPC5 ● PSME2 PSMB9

●

PSMD9 PSMD2PSMC3PSMD13 PSMD3 ● ● ● ● PSMB5 CDC27 ANAPC10 PSMB10 ● PSMB6 ● PSMB3 ● PSMC4 ANAPC5 CDC16 CDC20 ●PSMD4 ● PSMD12 ● UBE2E1 ●● ● ● CUL1 ● ● ● PSMC5 PSMD11 PSMD8 ● PSMB8PSME1PSMD6 PSME2 ● ● PSME3 ● ● ● PSMD5 PSMB9 ●

●

CCNA2 ●

●

●

●

PSMA3 PSMA4

●

●

PSMC1 PSMB7

●

● ● PSMB4 PSMB2 PSMD1 PSMB1 FZR1 MAD2L1 UBE2C ● ●● PSMA5 PSMC2 BUB3 ● CDK1 ● ● PSMD14● PSMD7 PSMD10 PSMA2 ● ● SKP1 ● PSMA1 ● ● CCNB1 PSMF1 ● ● PSMA6 ● BTRC ● PLK1 BUB1B ● ● ● ● CCNA1 ● PSMC6 ● ● UBB CDC23 CDK2 ● ● ● ●

●

●

●

● PSMC5 PSMB10 PSMA7 PSME1 PSMD11 ● ● ● PSMD4 PSMB3 ● ● PSMD2 UBE2D1PSMC3 PSMC4 ● ● PSMB7PSMC1 ● SKP1 PSMD9 ● PSMD13 ● ● PSMB6 ● ● ● PSMD6UBB CDC20 PSMD8 ● PSMA2 PSMB1 ● PSMD3 ● PSMB4 ● ● CCNA1 ● PSMA1 ● BTRC ● ● PSMC2 FZR1 UBE2E1 ● ● ● ● ● ● ●PSMC6 UBE2C ● PSMD7 PSMD5 PSMB2 CDK2 ● ● ● ● PSMD12 PSMA6 ● PSMA5 ● PSMD1 ● ●PSMB5 ● PSMA4 CCNB1 PSMF1 CDC27 CUL1 PSMD14 ● ● MAD2L1 PSMD10 PLK1● ● PSMA3 ● ● ● ● PSME3 CDC23 ● ● ● CCNA2CDK1 ● BUB3 CDC16 ● ● ● BUB1B ● ANAPC10 ●

●

●

●

Pathway: REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 There are 47 genes in this pathway. This pathway was detected by GSNCA





SKP1 PSMA7

●

BTRC

●

CDC20 PSMD9PSMD2 ● PSMD5 PSMD3 ● PSMC3 ●

PSMB8

● ● PSME2 CDC20PSMD13 ●

PSMA2

● ● PSMB10 ● PSMB6 PSME2 PSMD12 PSMB2● PSMA6 PSMD4 PSMB3 ● ● ● PSMC5● ● PSMB9 ● PSMB5 PSMD13● ● PSMD14 ● PSMA4 ● ● PSME3 ● PSMD8 PSME1 ● ● PSMB8 ● ● PSMA3 ● PSMA5 PSMD1 ● CUL1 ● ● ● PSMC1 PSMD10 FZR1 PSMB7 PSMC4 ● ●● ● PSMD11 ● ● PSMD7PSMF1 ● ● PSMB1 ● BTRC PSMA1 PSMB4 ● ● PSMD6 ● ● PSMC2 UBB ● PSMC6 ● ● ●

●

●

PSMB9

● PSMD3 PSMD4 PSMB10 PSMD5 PSMC3 PSME1 PSMC5 ● ● ● ● ● ● PSMB3 ● PSMD8 PSMC4 PSMA6 ● PSMA7● ● PSMD11 PSMB6 ● PSMD2 ● PSMD9 PSMB2 PSMB5

●

●

●

● PSMA4 PSME3 PSMD14 ● ● PSMA5 PSMA3 ●

●

● PSMB7

● PSMB4 PSMC1 SKP1 ● PSMA2 ● ● ● ●PSMB1 ● CUL1 PSMD1 PSMD7 PSMD6 ● PSMC2 UBB ● ● ● ● PSMA1 ● ●PSMC6 PSMF1 PSMD10 ● FZR1 PSMD12 ● ●

●

●

●

Pathway: REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21 There are 52 genes in this pathway. This pathway was detected by GSNCA





UBB

CDKN1A PSMC6 ● PSMC2PSMD6 ● PSMA1 CDK2 ● PSMD10 ● PSMD7 ●

● ●PSMF1 ● ● CCNE2 PSMC4 PSMD11 PSMA5 PSMD14 ● ● PSMB1 ● ● PSMA6 PSMD1 ● ● PSMA3 ● PSMB4 PSMD13 PSMA4 ● PSMD5PSMC1 CCNE1 ● ● ● ● ● ● ● ● PSMB7 PSMB8 CUL1 PSMB2 PSMC3 PSME3 CCNA1 ● ● ● PSMA2 ● PSMD4 PSMB9 ● ●● PSME2 ● PSMD8 ● PSMA7 PSME1 ● ● PSMB10 ● PSMC5 PSMB3 ● PSMB5 ● ● ● CKS1B ● ●PSMB6PSMD12 PSMD2 ● PSMD3 ● ● ● PSMD9 SKP2 ● CCNA2 SKP1 ● ● ● ●

PSMB8

●PSMB9 PSME2 ● ● PSMB10 PSMA7 CDKN1A PSME1 ● ● ● ● PSMD4 PSMB3 SKP1 ● PSMD9 PSMB7 ● ● PSMC3 ● ● ● PSMA2 PSMA1 PSMB6 PSMC1 PSMD11 ● PSMD2 PSMD6 PSMD8 ●PSMC2 ● ● ● PSMC4 ● ●PSMB4 ● ● PSMD13 ● PSMC6 PSMB1 ● PSMD3 SKP2 ● ● ● PSMD12 ● PSMF1 ● ● CCNA1● PSMB2 UBB CCNE2 ● PSMD5 PSMD10 ● ● PSMD7 ● PSMA6 ● PSMA5PSMD1 ● CDK2 ● PSMB5PSMD14 ● ● ● PSMA4 ● CUL1 ● ● CKS1B ● PSMA3 CCNE1 ● ● ● PSME3 ● CCNA2 ● ● ● PSMC5

Pathway: REACTOME_SIGNALING_BY_TGF_BETA There are 15 genes in this pathway. This pathway was detected by GSNCA

BCR/ABL ALL Major Gene (BCR/ABL): SMAD3 Weight Factor: 1.373 Major Gene (NEG): UBE2D3 Weight Factor: 0.688

NEG ALL Major Gene (NEG): UBE2D3 Weight Factor: 1.307 Major Gene (BCR/ABL): SMAD3 Weight Factor: 0.755



SMURF1

FURIN

●

● TGFB1

FURIN

●

●

SKI

● SMAD4

SMURF2

●

●

●

SMAD7

TGFBR2

●

SMURF1 TGFB1

TGFBR1

●

●

●

●

SMAD6

●

● ZFYVE9

SMAD2

●

●

●

SMURF2

●

ZFYVE9

UBE2D1

●

UBE2D3

TGFBR1

● UBE2D3

●

SMAD6

SMAD3

●

SMAD3

●

SKI

●

TGFBR2

SMAD2

SMAD4

●

●

●

SMAD7

●

UBE2D1

●

Pathway: REACTOME_SIGNALING_BY_WNT There are 58 genes in this pathway. This pathway was detected by GSNCA





SKP1 PPP2R1B APC PSMA7 ● PSMB4 CTNNB1 ● CSNK1A1 ● PSMD11 ● PSMB7 ● ● PPP2R1A ● PPP2CB PSMD9PSME1 ●● ●PSMC1PSMB1 ● PSMD2 ●PSMD8 ● ● PPP2R5A ● PPP2R5C ● PPP2CA ●PPP2R5D PSMB10 GSK3B ● PSMD3 PSMB6 PSMC4 ● PSMA1 PSMC3 ● ● ● ● ●PSMD13 ●PSMB3 ●PSMC5 ● PSMC6 ● PSMB5 PSMD12 PSMD6 ● ● ● PSMD4

● ● AXIN1 PSMB9 PSMB8 PSMD5 ● PSME2 ● ● ● ● ●

PPP2R5B BTRC

●

●

PSMC2

PSME3 ●

● UBB PSMD7 CUL1 PSMD1 PSMF1● PSMB2 ● ● PSMA5 ● PSMD14 ● ● ● PSMA4 PSMA3

● ● PSMD10

● PSMA2 PSMA6 ●

●

●

●

●

PSMB8

●

PSME2 PSMB9 APC PSMD5

● ● ● PSMA6 ● PSME1 PSMD3 PSMC5 PSMB5 PSMB10 ● PSMD4 PSME3 ● ● PSMD13 PSMA4 ● PSMB2PSMA7 ● ● GSK3B ● PSMB3 ● ●PSMD14 PSMA3 ● ●PSMB6 PSMD8 PSMC3 ● ● PPP2R1ABTRC ●PSMA5PSMB7●PSMD9● ● ● CSNK1A1 ● ● ● PSMB4 ● ● ● PSMD2PSMC4 SKP1 PSMD1 PPP2R5D ● ● PSMD11 PSMA2 ● CUL1 ● ● ● PSMD7 CTNNB1 PPP2R1B PPP2CB ● ● ● PPP2CA PSMC1 PSMF1 PSMB1 ● PPP2R5B ● AXIN1 ● ● ● PSMA1 PSMD10 ● ●PSMD6 ● ●● ● ● UBB PSMC6 ● PSMC2 PSMD12 ● PPP2R5A ● ● ● PPP2R5C ● ● ●

way: REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHE There are 16 genes in this pathway. This pathway was detected by GSNCA





CCT7

●

KIFC3

CCT3

●

●

SKIV2L

CCT3

●

●

●

USP11

●

●

● CCT8 FKBP9 ●

●

●

●

KIFC3

● FBXL5

ARFGEF2 CCT6A

CCT4

ARFGEF2

●

● ●

●

SKIV2L

CCT2

●

CCT5 NOP56

●

TCP1

LONP2

CCT6A

CCT4

CCT5

●

CCT7

●

NOP56

●

●

USP11

●

●

CCT2

TCP1

●

●

FKBP9

FBXL5

●

● LONP2

●

CCT8

●

Pathway: NAKAMURA_CANCER_MICROENVIRONMENT_DN There are 33 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CCNB2 Weight Factor: 1.473 Major Gene (NEG): IARS Weight Factor: 1.231

NEG ALL Major Gene (NEG): IARS Weight Factor: 1.396 Major Gene (BCR/ABL): CCNB2 Weight Factor: 1.351



SYNCRIP

NDUFA9

●

PA2G4

●

PSMG1

●

ASNS

RFC4

●

● DHRS3

●

RIPK2

● ●

NDUFA9 FANCI AURKA

●

●

●

SPAG5 KIF2C CCNB2 BUB1 ● ● ● ● TRIP13 IARS

●

DHFRRFC5 CDC20 LSM4 ●

●

ASNS

PSPH ● SYNCRIP ● ● ● SPAG5 ● HOMER2 ● MARS ● TXNRD1 PA2G4 ● ● ARTN TARS ● IARSSLC7A11 ● ● ● ● FANCI TCP1

PSPH●

●

● CARS HOMER2 ●

●ARTN AGPS ● ●

●

CTH

●

●

MARS

●

TARSTCP1

● ●

CCNB2

KIF2C

BUB1

●

RFC4

●

AURKA

●

CDC20

DHFR

● CDC6 RFC5

●

●

●

●

TRIP13

●

●

BCAT1

CARS

● ●

●

●

PSMG1

●

AGPS

● RIPK2

CTH

●

SLC7A11 TXNRD1

●

BCAT1

CDC6

●

DHRS3

●

LSM4

●

Pathway: KORKOLA_EMBRYONAL_CARCINOMA_UP There are 24 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ARHGDIB Weight Factor: 1.398 Major Gene (NEG): EMG1 Weight Factor: 1.034

NEG ALL Major Gene (NEG): EMG1 Weight Factor: 1.195 Major Gene (BCR/ABL): ARHGDIB Weight Factor: 1.133



RAD51AP1

SLC2A3

●

● GABARAPL1 RECQL

GABARAPL1 SLC2A3 KRAS

● ARHGDIB ● PTPN6

● ●

●

●

LRP6 ETV6

● CD9

●

●

LDHB

●

PHB2 RECQL

●

NDUFA9

●

LDHB

●

● TEAD4

BCAT1

CCND2 TNFRSF1A ●

●

EMG1 NDUFA9

● ENO2 ●

●

●

● ●

●

ARHGDIB KRAS

GPRC5A ENO2

●

KLRD1

●

●

●

●

● ●

CD9

ETV6

TPI1

GAPDH

NOP2

●

EMG1 BCAT1 ●

PHB2●

TEAD4

PTPN6

●

●

●

KLRD1

CCND2

NOP2

●

LRP6

●

●

●

●

TPI1 RAD51AP1 ● TNFRSF1A ●

● GAPDH

●

GPRC5A

●

Pathway: KORKOLA_SEMINOMA_UP There are 28 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ARHGDIB Weight Factor: 1.294 Major Gene (NEG): ATN1 Weight Factor: 1.193

NEG ALL Major Gene (NEG): ATN1 Weight Factor: 1.359 Major Gene (BCR/ABL): ARHGDIB Weight Factor: 1.061



KLRG1

ERC1

● TULP3

GNB3

●

●

●

NOP2 VAMP1

●

●

●

TEAD4 TSPAN9

●

●

NDUFA9

●

ARHGDIB PHB2 KLRG1 PTPN6 ● GAPDH ● ● ●

LRP6

●

● CD9 ● CREBL2COPS7A ● SLC2A3 ● CD27 GABARAPL1 LDHB ● ● ● ● RECQL

EMG1

●

●

ATN1

●

GPRC5A

●

ENO2 ● VAMP1

● ATN1 ● RECQL ARHGDIB ● PTPN6 ●

ERC1

●

●

CCND2

●

●

● GPRC5A ●

CD27

●

CD9

● COPS7A ●

LDHB

PHB2

NOP2EMG1 CREBL2

● ●

● GABARAPL1 ●

ENO2

●

● ● LRP6 TEAD4 ● ● NDUFA9 ●

●

TPI1

TSPAN9

TULP3

GNB3

SLC2A3

●

CCND2

●

TPI1

● GAPDH

●

Pathway: HOLLMAN_APOPTOSIS_VIA_CD40_DN There are 186 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): GTF2H5 Weight Factor: 1.423 Major Gene (NEG): CDKN1B Weight Factor: 1.141

NEG ALL Major Gene (NEG): CDKN1B Weight Factor: 1.401 Major Gene (BCR/ABL): GTF2H5 Weight Factor: 1.205



HIST1H2AC HIST1H1C NPC2 HIST1H2BF HIST1H2BE ●● SUB1 ●RPL36AL ● GMFG XK●● ● CASP1 CASP6 CPOX FADS1 ● UBE2L6 ● B3GALNT1 ZNF239 ZNF124 GSTO1 PSME1 DECR1 RPL8 ● CTSC ● NINJ1 ● TAP2 SATB2 GATM RPN1 ● IFIH1 ● ● ● ● ● MTMR2 HOXB7 ● HDAC9 TRIM44 ●CD79B ●RRBP1 ● CTNNA1 ●● ANKMY2 ●EEF1D PSMB8 ●●GNPDA1 NUPL2 PSPH SMARCE1 PSMB9 ACOT13 LGALS3BP STAT1● LAMB4 ●SERPINH1 ● HLA−G ZAP70 ● ● ● ●SEPT11 IGLL1 ● ● ● ● RAG1 ● HSBP1 ● ● GOSR1 XBP1 SEC23IP RNASE6 ● ●PPP1CA ● ●BRE HLA−J ●RASGRP2 ● TSTA3 VIM HOXA10 ● LDB3 MT1X DNPEP ● ● ● S1PR4 TRIM13 ● PPM1F STAMBP NME4 CANX ● MGST2 NUDT1 ● ● IFFO1 MPZL1 ID2 ● ● UGDH RYK ● TOR1AIP1 VPS72 ● ZKSCAN4 CD58 ● GTF2H5 ● TRIP6 ●PPP3CA ●● ● TLE1 ● ●ATP6AP1 UROS ●● ●● ST3GAL5 ● ● ● ● ●HOMER1 ● ● BTN3A3 TMX1 ● ●DPY19L1 ● ● ZNF195 ● ZNF45 ● ● ●TP53 GPX1 CREG1 SLC16A3 AP3B1 ● ● ●● CDKN1B LY75 MYD88 ●TARS ZNF22 ● BRD3 ● ZNF193 PKIG ● ●● ● SP140 TCF4 MIPEP ● HOXB6 HLA−E ● TCL1A F13A1 ● PHYH ● ● HCP5 ●AEBP1 ● APBB2 ●● ●● KLHL9 ●PCBD1 ●● ●●MGAT2 MBP PDE4B EFR3A ● FADS2 SUCLG2 ●●● LITAF PON2 ●RCN2 ZNF274 IFITM1 ●TES ELOVL6 TSPO ● CASP4 ● ● ● ● PGM1 ● CD9 MSX1 ● CDH4 ● SERPINB1 ● GAB2 ● ● ● CCBL2 CXCR4 ● NADK ●SYNGR3 TMEM131 BCR PLXND1 TRIM22 CASP7 ● NOTCH2 USP7 ●●OSR2 ●SERPINF1 DENND5A ●● E2F6 ●TRAM1 ● SKAP1 ● ●ZC3HAV1 ZNF238 KLHL21 ANXA2 HLA−F ● ● ● ● SATB1 ●● NEK3 PDLIM1 ●● ●● ● ●QPRT ● SPINT2 MX2 CHMP2B TDRD7 ● SPTBN1 ●●● CPVL ● ●AGPS ● ● KIAA0182 ● ● ● ●● BMP7 OXSR1 ● ● ● CSDA ● ●● ● S100A11 ANXA5 ● ● ● ●ABL1 ● GTF3C1 ●

●●

●

●

B3GALNT1 GATM ID2● CASP6 MBP SYNGR3 RRBP1 ZNF45 IFIH1 KLHL21 LAMB4 ● ● ● ● ● SUB1 GOSR1 MTMR2 ZNF239 HOXB7 ● RYK ● ●HIST1H2AC EEF1D ● BMP7 CREG1 ●CCBL2 ●● ZAP70 ● DPY19L1 ●LITAF CTNNA1 RPL8 ● ●● HLA−G FADS1 TRIM44 PPP3CA NINJ1 ● ST3GAL5 HLA−J ● ANXA5 TOR1AIP1 ● BRD3 ● RASGRP2 ● ●RPN1 FADS2 ●● ●ELOVL6 HIST1H1C TLE1 ● PPP1CA ●ABL1 ● ● ● SPTBN1 NME4 ● ● ● ● HIST1H2BF CASP7 S1PR4 TSTA3 RPL36AL MGAT2 ● USP7 STAT1 ● ●OSR2 CHMP2B ● ●TSPO HOXB6 CASP4 MT1X ●● ●● ● IGLL1 ● ● ● EFR3A ● ● ● CD9 HIST1H2BE ● ● ZNF274 ● ●● GAB2 BCR ● MYD88 ● SPINT2 ●CDKN1B CSDA SUCLG2 CDH4 TDRD7● TRIM13 ZNF238 ● NEK3 ● CXCR4 ● SEC23IP PSME1NOTCH2 NUDT1 ● ● ● ● ●●●TRAM1 TP53 NPC2 PCBD1 ● HDAC9 ● MPZL1 PSMB8 UROS ● ● ANKMY2 ● ANXA2 PSMB9 TRIM22 TAP2 ● NADK ZKSCAN4 ● MSX1 ● ● CASP1 E2F6 ● ● SERPINH1 ●●●UBE2L6 ● MX2 ●ZC3HAV1 SMARCE1 ● AGPS ●● ●●DNPEP GNPDA1 S100A11 ●ZNF124 ● HOMER1 ● ● SKAP1 LGALS3BP TMEM131 ● HCP5 ● SEPT11 ● GTF2H5 ● ATP6AP1 ● HLA−F GSTO1 IFITM1 ● ● ●CTSC ●AEBP1 BTN3A3 GMFG ●● ● PPM1F ● QPRT ● HSBP1 ZNF193 ● ● SP140 ● BRE CD79B ACOT13 ● ● ● ● RCN2 HLA−E ● ● ● ● ● ● ●● PSPH ●STAMBP ● ●● CD58 ● SERPINB1 LY75 TES SATB1 VPS72 ● ● DENND5A CPOX ●APBB2 ● ● IFFO1 HOXA10 GPX1 ● ●●●DECR1 TRIP6 ● KIAA0182 PLXND1 ●VIM PKIG ● ●● ● KLHL9 ●OXSR1 TMX1 ● XBP1 ● ●NUPL2 ● TCL1A UGDH PDE4B TARSPON2 ● ●● ●RNASE6 ● MGST2 ● ● SATB2 CPVL ● ●SLC16A3 ● GTF3C1 ●●ZNF195 ●CANX ● MIPEP XK PHYH●AP3B1 ●● ●● ● ● RAG1 SERPINF1 PGM1 ● ●F13A1 LDB3 ● ●ZNF22 ●● ● PDLIM1 TCF4 ● ● ●

●

●

● ●●

Pathway: TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN There are 47 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CX3CL1 Weight Factor: 1.35 Major Gene (NEG): CNN1 Weight Factor: 1.133

NEG ALL Major Gene (NEG): CNN1 Weight Factor: 1.373 Major Gene (BCR/ABL): CX3CL1 Weight Factor: 1.084



SCGB2A2

ACTG2 CSDA

●

●

●

CFD SYNM MYH11 ● ID4 SCGB2A2 ●ZNF204P

●

●

● ● PI15 PDZK1 PTN CADM1 ● ● SERPINB5 ●● SENP6 ELF3 TAGLNKRT17 ● ADH1B ● ● ATP10D KRT14 ● ● NTRK2 KRT5 GABRP ● ● CAV1 ELF5 ● ● CNN1 CX3CL1 ● CRYAB ● MAOA ● GPM6B ● PROM1 MGP

●

●

●

SFRP1 NFIBPIGR

● ● ● MYLK RCAN1

●

● ZBTB16

●

● ●

● CSNK1A1 ACTA2 ● GHR FOS ANXA1 ● ● ● ● ATP1A2● ATF3 MMP7 FOSB ●

●

●

●

ID4

CAV1 SERPINB5 SYNM

● CADM1 ● ● ADH1B ● ELF3 ● ELF5 ● PDZK1 FOS KRT14 ● CRYAB ZNF204P KRT5 ● ● ● ● FOSB ATF3 ● ● ● SENP6 ● ● MMP7 GPM6B ACTA2 CNN1 ● ZBTB16 PIGR CSDA ● ● ● PTN ●● ● ●ATP10DPROM1 MAOA ● ● CSNK1A1 TAGLN ● ● CX3CL1 NFIB ● ● PI15 MYH11 ANXA1 RCAN1 ● ● CFD ● ATP1A2 ●NTRK2 ● ● ● SFRP1 ● MGP ● ACTG2 ● KRT17 ● GHR ● GABRP ● ● ● MYLK ●

Pathway: DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN There are 93 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): RPS12 Weight Factor: 1.362 Major Gene (NEG): RPL32 Weight Factor: 1.093

NEG ALL Major Gene (NEG): RPL32 Weight Factor: 1.581 Major Gene (BCR/ABL): RPS12 Weight Factor: 1.333



KLF4 SGCB ● SLC16A7 ● ME1 IRF8 GPR137B CD53 PTPRE CCR2 ● CDH2 ●RPL39 GPX3 ● GATA3 ● MVP ● ● ZNF124 BCR ● MN1 ● SATB1 ● FZD2 ELANE BLNK● ● ●ADD3 CRYGD ●CCR7 ● BTG2 ● ●IL16● ● TCF7 ●ANXA5 ● ● HAL SLC1A3 ● TERT FLT3 DNTT● ● DFNA5 S100A9 S100A8 ● MYLKMPO EPB41L3 ● ● ● ● BCL6●MNDA ● ● OAS2 VAMP5 ●CSTA●IFI30 ● ● CST7 ● LY86 ● GADD45B ● ●FGL2 ● FGFR1 ● ● ●CSF1R ● NKG7 MCL1HMHB1 CEBPD LPL FLNB ●●● ● IL10RA ● FAAH ACTG1 ANK3 ADA ●RPS15 ● IL7R ● ●HLA−DMB ● TLR2 MYOF PRNP ● ● CAPN3 ● ●IRF7 ● GAPDH GAS7 ●●RPS11 ● TGFBI SELL PROM1 ● IL13RA1 SORL1 ● ● RPS12 ●EEF1A1 ● ● LILRB4 ● ● ● ● ● ● ● ● INSR ●● RPS24● CRHBPISG20 F13A1 RPL32 ●● NINJ1 ●GLIPR1 RPL30 ● RPLP1 ● RPL23A ● ● ●RPL41 ●

●

●

RPLP1 RPL23A ACTG1 ● RPS12 MNDA ● RPL41 ● S100A8 MN1 RPL30 ELANE ● GLIPR1CRHBP ● ● RPS24 MPO ● EEF1A1 RPS11 RPL32 ● ● ● ● ●● ● ANK3 ● FAAH ● ● CSTA KLF4 LY86 SLC1A3 RPS15 S100A9 ● ● TERT FLNB ● SLC16A7 ●SELL NINJ1 ● IL7R ● CSF1R ● LILRB4 ● PTPRE ● INSR ME1 ● ● ● ● ● ADA ●IFI30CRYGD SATB1 ● GPX3 ● ● PROM1 FLT3● RPL39 ● SGCB LPL CAPN3 ● SORL1 ● ● ANXA5 ● GATA3 ● FGFR1 ● ● ● ● CCR2 ● TGFBI ● ● EPB41L3● CD53 ZNF124 GAS7 MVP● BCR ●GPR137B HAL GAPDH ● ● PRNP ● BLNK HLA−DMB ●ADD3 ●FZD2 NKG7 ● BTG2 DNTT ● ●F13A1 ● IL16 ● ● ● FGL2 ● ●● CCR7 ● DFNA5 ● ● ● CST7 MYLK MYOF MCL1 ● ● IL10RA ● ● VAMP5IRF7 TCF7IRF8 ● ● ● ● CDH2 CEBPD OAS2 ● ● ● TLR2 ● ● GADD45B ● ISG20 ● IL13RA1 ● BCL6 ● ● ● HMHB1 ● ●

●

Pathway: CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP There are 27 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NID1 Weight Factor: 1.275 Major Gene (NEG): TMX4 Weight Factor: 1.059

NEG ALL Major Gene (NEG): TMX4 Weight Factor: 1.303 Major Gene (BCR/ABL): NID1 Weight Factor: 0.944



FOSB

● FOS

●

ENC1 ANXA5

●

CEBPD

●

●

CLU

●

●

NAGPA FCGRT HDAC4 ENTPD1 ● ●

SLC36A1

●

●

●

NID1

TRIM27 ● LAMC1

● ●

●

EVI2B SLC36A1

●

●

●

FBN2

●

LAMC1

●

●

HDAC4FOSB

●

TFEC

●

GCA ● PLA2G16

●

PTGER2

●

ENC1

● KLF4

TFEC

NAGPA●

GCA CAPN3

●

● ●

●

CEBPD

●

●

CLU

●

FZD2 TGFAFBN2

TMX4

●

FAM105A SLC38A6

●

●

PLA2G16

ANXA5

KLF4

●

SLC38A6 NID1 ● ● TGFA FCGRT ● ENTPD1 ● FAM105A ●

●

FOS

● PTGER2

●

TMX4

● FZD2 CAPN3 ● EVI2B TRIM27 ●

●

●

●

Pathway: GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_UP There are 19 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PHLPP2 Weight Factor: 1.326 Major Gene (NEG): NUP153 Weight Factor: 1.208

NEG ALL Major Gene (NEG): NUP153 Weight Factor: 1.332 Major Gene (BCR/ABL): PHLPP2 Weight Factor: 0.995



SLC7A1

LDLR

●

HMOX1

●

●

●

NPC1

● NUP153 LDLR ●

●

●

JHDM1D GCLM

●

NUP153

●

●

ATXN7

●

GCLC

KITLG

●

●

KLF4 GCLC

●

GCLM

●

KLF4

●

XPO1 TNPO1

●

● GK

●

NAV3 TULP3

NAV3

PHLPP2

●

●

●

XPO1

●

JOSD1

PPP3R1 NPC1

●

●

●

JOSD1

●

●

TNPO1

TULP3

PPP3R1

HMOX1 GK

●

●

JHDM1D ATXN7● ●

SLC7A1 PHLPP2 ●

● ●

KITLG

●

●

Pathway: TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP There are 120 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IFI27 Weight Factor: 1.338 Major Gene (NEG): CELA2A Weight Factor: 1.273

NEG ALL Major Gene (NEG): CELA2A Weight Factor: 1.355 Major Gene (BCR/ABL): IFI27 Weight Factor: 0.958



HLX RNASE6 STAT1 ● RSAD2 ISG15 CLEC2B IRF9 ● IFIT3● OAS2 ● ● ● OAS1 ● GUCY1A3● ● BST2 MX1 LY6ECD69 EVI2A ● MVP SP110 ● SCN2A MX2 SPINK2 ALDH1A1 GBP1 ● RAB27B ● ● ARID5B ● ●●IRF7 DST ●● SERPING1 CRISP2 ● ● BMP2K● AUTS2 ● ●● STAT2 ● XAF1 IFI35 CRHBP ●HIST1H2AC AHR MEIS1 NEAT1 ● RTN1 ●● ●IFI44L ●IFI44 OFD1 ● TRIM22 PTPN13 CTSG IGFBP4 ● ● HOPX ● SLC5A3 ● ● RBPMS ● ● ● CDKN1C ● ● PHACTR4 LGALS3BP ● ●GALNT2 MAP7 ●TCN1●IFIT5 ● IFIH1 PCDH9 ● SCN9A ● ARHGAP22 CELA2A ● TRIM9 IFI6 CLSTN3 CRISP3 ● IGJ ● ● ● ● ● PTGER3 ● ● SOX4 PLA2G4A CH25H ● ● EIF2AK2 ● RPS6KA5 ● ●● TTC28 TXK PBX3 IFITM1 ● IGHM HOXA5● ● GMPR DMXL2 ● ●VNN1 RHOBTB1 ●FGF18 PTGS2 ● ●HOXB3 ● ● ● KIAA0513 S100A10 ● ●● MLLT3 ● PRSS23 ERG ● ● ● IFIT1 OASL MECOM LOX ● NFAT5 ANGPT1 ● ● ● ● REN IFI27 ● QPRT ATP1B1 IFI16 TOX●● ● ● ● ● IFIT2 CYP1A1 ● IDO1 ● ● ●CCL18 CXCL10 CAV1 ●MYCN ● ACSM3 ● TRIM25 ● PTPRD ● ● BAMBI ● ANGPT2● ● KLF5 PTGS1 ● CELA2B ● ● ● ● ADRB1 ● ● ● ● ITGB8 ●

●

●

NFAT5 LOX CXCL10 PTGS2 RPS6KA5 ●TRIM9 ● ● GMPR VNN1 CRISP2MECOM ●PLA2G4A RTN1 ● ● IFIH1 ●● GUCY1A3 IFI27 NEAT1 EIF2AK2 MEIS1 ● ERG ● ● ● DST ● ● IFI6 CAV1 ● BST2 ● MAP7 ● S100A10 ● ● IFI44 ● SPINK2 RSAD2 TCN1 ● IGHM RAB27B ● TOX ● IFIT5 IFI44L ●● CDKN1C ● MX1 MLLT3 IFIT1 ● KIAA0513 ●● ● IRF9 ● ● ● ● ACSM3 ●IRF7 ANGPT2 ●HOXA5 SCN9A ●OAS2 ● ●OAS1 RBPMS ● SOX4 HOPX CRISP3 ● ● ● CLSTN3 CH25H ● ● ● ● ● MX2 ● TXKPBX3● CRHBP IFITM1●ISG15 FGF18 SCN2A GALNT2 ●● ● ●LGALS3BP GBP1 ● ●CELA2A IFIT3 ●CCL18 ● ●BMP2K ●● ● SP110 HIST1H2AC IGJ ● RNASE6 IDO1 ● ● LY6E KLF5 STAT1 ● ●TRIM22 ●●PTPRD TTC28 SLC5A3 OASL CTSG ● ● ● ● PCDH9 ADRB1 ● ITGB8 XAF1 IFI35 ●IFIT2 ● ●STAT2 CYP1A1 ● MVP ● ● IFI16 ●PRSS23 ● RHOBTB1 MYCN AHR ● AUTS2 ● ● ● ● ● ARID5B ●PTGS1 ANGPT1 ● ● TRIM25 ● DMXL2 IGFBP4 ● ● QPRT ● ● HOXB3 BAMBI OFD1 CELA2B RENCLEC2B ● ● ● ATP1B1 ●● ● ● PTGER3 ●ARHGAP22 ● SERPING1 EVI2A ● ●● ● ● ● ALDH1A1 HLX CD69 ●PHACTR4 PTPN13

●

● ● ●● ● ●


BCR/ABL ALL Major Gene (BCR/ABL): GAD1 Weight Factor: 1.346 Major Gene (NEG): FGF18 Weight Factor: 0.965

NEG ALL Major Gene (NEG): FGF18 Weight Factor: 1.348 Major Gene (BCR/ABL): GAD1 Weight Factor: 1.158



NR4A2 IFIT5 DDIT4 CLEC2B GCH1● ●IFIT2 DHRS3 MEF2C ● ● ● XAF1 IGLL1 ANGPT1 ● IFIT3 TSC22D1 ●● ● CELA2A BDNF PRSS23MYCN OAS2 OAS1 LY6E ● ● REN● IFI27APOC1 GBP1 ●● HOXB3 ● ISG15 ● THBS1 ● SPINK2 MTSS1 IFI6 SOX4● ● ● ●DLC1 ● IFI44L ● ●SLC6A13 ●ADRB1 MX2● ● ● ●RAB27B CDH1 ENPP2 ● HIC1 ● ●MX1 FGF18 ● RPS6KA5 ● PTGS2 ● TTC28 ● ● KRT18 ● IFI44 ●KLF1 ● GZMB ● ● RSAD2 ● ● IFIT1 ● ● ● ● FHL2 FLT3 HBBP1 ● TAL1 AMMECR1 RHAG IGFBP4 STAT1 ● ● ● ● ● ● ●● DEFB1 ATP7B CTSG ● ● MECOM IDO1 HBD SPTA1 ADCYAP1 MAP7 IFIH1 HOXA5 ● TYRP1 ● ●GAD1 CHST2 ● GJA1 ● RBPMS ● ● ● ●● PRKAR2B DNAJC6 ● HBB TUBB2A MEIS1 ●●● TGM5CALB1 RHOBTB1 ● ●NMU MYH10 ● ● CRISP3 ● ● ● ● ● IFITM1 PALLD TNFAIP6 ● SPOCK1 ● ● ABCB1 AUTS2 LGALS3BP ● ●IGJ● ●PCDH9 FAT1 ● FOXC1 IRF7 ALDH1A1 ● ● ● ● ● F2R ● CCR7 HOPX ● ● ● GPR18 ●

●

●

●

GBP1 ENPP2

IFIT5

● ● MX2 OAS1 IFITM1 ● IFI6IFI27 MX1 IGJ LGALS3BP IFIT1 ● MTSS1 ● ● ● IFI44L IGFBP4 ● ● OAS2 IRF7 ● IFI44 ● ● ● ● ● ● AUTS2 APOC1 ● BDNF FAT1 IFIT2 ISG15 ● TTC28 ● ●KRT18 CTSGDLC1 RSAD2 ● ADRB1 IFIT3 ● ● ABCB1 SOX4 ● ● XAF1ANGPT1 LY6EALDH1A1 ●REN● ● ●RAB27B ● PCDH9 STAT1 ● ● HIC1 ●CELA2A ● PRSS23 ● HOXB3 SLC6A13 TSC22D1 ● ● ● PTGS2 ●● MECOM AMMECR1 ● MEF2C GZMB ●● GCH1 ● THBS1 ● ● ● ●TNFAIP6MYCN IGLL1 ● ●GPR18 FGF18 ● ●● TGM5 NMU ● ● ● HOXA5 PALLD CRISP3 IDO1 ● CALB1 ● ● ● CHST2 CLEC2B ● SPOCK1 ●NR4A2 SPTA1 FOXC1 ●● ● RBPMS ADCYAP1 GAD1 ● RHOBTB1 ● ● DDIT4 MYH10 ● DEFB1 TUBB2A ● ● ● MAP7 ● ● RHAG ● ATP7BCCR7PRKAR2B ● ● ● FHL2 FLT3 ● TYRP1 ●IFIH1 ● CDH1 ● RPS6KA5 ● MEIS1 ● TAL1 ● ● ● ●DNAJC6 ● ● HBBP1 ● ● GJA1 HOPX DHRS3 ●KLF1F2R HBD ● ● ● ● ● HBB ● SPINK2 ●● ● ●


BCR/ABL ALL Major Gene (BCR/ABL): DEFB1 Weight Factor: 1.343 Major Gene (NEG): OASL Weight Factor: 1.156

NEG ALL Major Gene (NEG): OASL Weight Factor: 1.336 Major Gene (BCR/ABL): DEFB1 Weight Factor: 1.146



LILRA2CDC42EP3 GNAI1GPR18 AFF3 ANGPT2 ABLIM1 ●KIT ●FCER2 ADRB1 ●TIMP3 ● ●SLC8A1 ● ●● SLC6A13 PTGS2 ● EIF2AK2 ● FLT3 ● ●TOX FGF18 HPGD ●REN ● XAF1 ● FN1 ● ● IFI27 HBD CKB ● HBB ● ● IFIT2 DUSP4 IFIT3 SERPINE2 ● ●IFI44 HOXB3 ● ● ● ● OASL ARL4A USTFAM134B DEFB1 ● IFI6 STS ● ● DLC1 ● GMPR TYRP1 ● ATP10A● ● ● ● ● ●STAT1 ZEB1 ● ● LY6E ● ● ISG15 ●● IDO1 IFIT1 IFI44L ● SOX4 CHRNA6 ● TM4SF1 TGM5 GEM KRT18 ● ● INPP4B ARHGAP5 DNAJC6 CFI HOXA5 ● ADCYAP1 ANGPT1 ● ITGB7 ● HMGCS1 ● MX1 CXCL10 ● ● ● RBPMS ●● FERMT2 IGLL1 ● ● CDH1 ● SLC5A3 ● ● ● RARRES3● PALLD SCN2A ● ● CALB1 ● ●MFAP3L SPOCK1 ● GBP1 ● ● ● FLNB IFIH1 CCR6 ● NR4A2 ● ●ARG2● IGJIFITM1 ●LSP1 HOPX HBBP1 ● ● ●RSAD2 DBN1 ZNF711 ● MX2 ● ● TRIM9 ● ● TNFAIP6 ● ● ● GATM ● OAS2 ● ● MEIS1 ● ● AUTS2 CD38 RAB27B ● LGALS3BP ●CADM1 ● PRKAR2B ALDH1A1 ● ● IL15 SP110 CAV1 IRF7OAS1 ●DHRS3 ●● ●MCM4●●CD1D ● LGALS2 ● DMD ● ● ●● ● ● THBS1 ● CFD ● CFP ● ● EPCAM SPINK2 ● CDKN1C ● ●

●

●

●

ARHGAP5 IFIT2 OAS2 ● IFIT3 OASL ANGPT1 STAT1 ● OAS1 RSAD2 ● ● ISG15 ● IGJ IFIT1● ●LY6E LGALS3BP EIF2AK2 ● ●IFI44L ●IRF7● SP110 XAF1 IFITM1 ● IFI27 IFI44 ABLIM1 MX1 ● ●●● ● GBP1 ●● MX2 ● ● RARRES3 ● IFI6 ●●LSP1 GMPR ARL4A ● ● IL15 ● ● ALDH1A1 ● FAM134B ●CDH1 ● HBBP1 AUTS2 CCR6 HBB ● MFAP3L ● EPCAM CFP PALLDMEIS1 ●● ● ● ●TM4SF1 ITGB7 ● HMGCS1 ● HBD ● CAV1 CDC42EP3 GPR18 ANGPT2 ●● ● IFIH1 GNAI1 SCN2A ● TOX ZEB1 DUSP4 SOX4 ● ●TNFAIP6 ● FERMT2CD38 DNAJC6 ● ●DBN1 LGALS2 ● PTGS2 CALB1 ●● INPP4B DHRS3 SPINK2 ●UST ● CD1D ● ● ● ● RAB27B SLC5A3 GATM SPOCK1 TRIM9 ● ● CDKN1C ● ● ● ● ● ZNF711 FLT3 ● ● ● ● ● ● TGM5 ● FCER2 RBPMS ● ●KIT● DMD CFD GEM ● ADCYAP1 HOPX PRKAR2B CFI● ● TIMP3 ● STSNR4A2 ●CADM1 ● ● ● ● FLNB ● CXCL10 ● DLC1 ● ● IGLL1 ● ● ● HOXA5 MCM4 ● ● ● FGF18 AFF3 HPGD ●LILRA2 SLC8A1 ARG2 IDO1 CHRNA6 ● ● ●●THBS1 ● ● TYRP1 ●● ● FN1 SERPINE2 SLC6A13 ● ● ● HOXB3 ADRB1 ● ● ATP10A ● DEFB1 ● CKB ● ● ● ●●REN ● ● KRT18 ●

●


BCR/ABL ALL Major Gene (BCR/ABL): IFI27 Weight Factor: 1.394 Major Gene (NEG): HPGD Weight Factor: 1.374

NEG ALL Major Gene (NEG): HPGD Weight Factor: 1.453 Major Gene (BCR/ABL): IFI27 Weight Factor: 1.002



PDLIM1 XAF1 IFIT3 SOX4 WT1 ● ● HOPX ● ● ●IFIT2 IFITM1 CD38PPP1R16B ● ●FLNBAHR ● OAS2 ● MAP4K1 ●ISG15NCALD ●OASL FCARDUSP4 ● CHST2 ITGB7 IFIT1 ● HOXB3 ● IFI44 ● ● GNAI1 LSP1 ● ● ● CD1A ●IFI44L PALLD ●THBS1 MX1 CDC42EP3 ● ● ● ● IFI27 TFR2● NRG1 ● ● ●● MX2 CD1C ● KIT FKBP1BLY6E PTPRK ● ●TOX ● ● EREG ● RAB27B SPINK2 ● ● IFI6 ● ● ●CPA3 ● HBB ADRB1 CES1 ● ● ADAM19 HOXA5 SMPDL3A ATP11A ● BCL2L11 GPR18 REN TGM5 ● RSAD2 LAMP3 ● ● ●● ● HBD STAT1 ●●NET1 HPGDCFI IDO1 ● ● ● ●● LILRA1 ● SAMHD1 ●●FHL2 ABCB4 LIFZDHHC17 ● ● CDH17 MEF2D ● ●● IKZF1 CD1D ● ● ELOVL6 ●ITGA7 ● PRKAR1A ● AFF3 HOMER2 ● NDRG2 ● ● DEFB1 PRSS3 CFD PRKAR2B ATP10A IRF4 ●● FGL2 ● ● ● ● ● ● FN1 ● MEIS1 ● ●PTGFR SIGLEC6 SLC5A3 ● LGALS2 FCER2 SLC18A2 XYLT1 ● HOXB2 CFP ● ● ● ●GEM ABCD2 CCNA1 ● ● LUM ● ● ●● ●● PTGS2 ● ●● TNFSF10 ● GPX7 CD1ECCR2 ● RAB33A CCR6 AUTS2 ● ● ● LTBP1 ● ● ● IL6ST ● ●

●

●

SAMHD1 PTGS2 LAMP3 SLC18A2 SMPDL3ACCR6 IKZF1 ● TNFSF10 CFI● LUM PALLD ● ITGA7 ●TGM5 MX2ADAM19 ● ● ●ABCD2 CDC42EP3 ● CD1A ● CDH17 HOXB2 ● ● ●● GEM ●EREG SPINK2 ● HBB ● ●FGL2 DEFB1 ● ●NRG1 NET1 ● IFIT1IFI6 ●IDO1 PTGFRCD1C ATP11A MX1 ● LTBP1 ● ● ● ● ● ● ● IFI27 RSAD2 ● ●CD1E CCR2 ● ● MEIS1 ● ● HOPXHBD ●GPX7 ● IFI44L ● ● MAP4K1 ● ● ● ● TOX ● FHL2 ● IFI44 CD1D FN1 ATP10A PDLIM1 TFR2 PRKAR2B ● ● NDRG2 ● OAS2 ● MEF2DFCAR ● ● ● PPP1R16B IFITM1 GNAI1 LILRA1 ● ●●KIT● ● CHST2 FLNB ● ● HOXA5 CCNA1 ISG15 ● PRSS3 ● ● BCL2L11 ●CPA3 ABCB4 ● CD38 ● LY6E ●● FCER2 ●ITGB7 WT1 ● REN LGALS2 ● IRF4 ● ●STAT1 ● ●HOMER2 ● ● IL6ST ●● ● PTPRK XAF1IFIT3 ● OASL AFF3 ●AHR ● CFP CES1 ● HOXB3 SIGLEC6 ●LSP1● ● ● ● ● ADRB1 ● ● AUTS2 IFIT2 THBS1 ● ● HPGD ● FKBP1B ● ZDHHC17 XYLT1GPR18 ●● ● LIF ● ● NCALD ● SLC5A3 ● CFD ● ● ● RAB33A ELOVL6RAB27B ● ●● ● DUSP4 ● PRKAR1A ● ● SOX4

●●

Pathway: BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_DN There are 28 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MRPL28 Weight Factor: 1.275 Major Gene (NEG): NKTR Weight Factor: 1.062

NEG ALL Major Gene (NEG): NKTR Weight Factor: 1.461 Major Gene (BCR/ABL): MRPL28 Weight Factor: 1.316



HLA−DQB1

●

● FSCN2 TNFRSF10B ● TBC1D5

● VTI1B

●

SEC24A

●

● ●

●

CD2AP NKTR ● MRPL28 ●

RXRB

●

SEC62 CDK8

ACOX1 NR2C1 ● CCND1 ● CCNG1 ● BTN3A3

● CCNG2

●

●

PIM2

● RGL2

●

MYB

●

FBXO21 PREP

●

● VPS52 ● DDX17

●

●

BTN3A3 ACOX1 VTI1B DDX17 SEC24A ● ● RGL2 ● ● VPS52 ● ● TNFRSF10B NKTR ● NR2C1 ● ● TBC1D5 ● RXRB FSCN2 MRPL28

●

●

SEC62 CCNG2

CDH2

●

●

FBXO21 ZFYVE26

●

●

ZFYVE26

DDR1

●

● CD2AP

●

●

PREP

CCND1● CCNG1 ●

CDH2

●

●

MYB ● ●

CDK8HLA−DQB1 PIM2

●

●

● DDR1

●

Pathway: HOEBEKE_LYMPHOID_STEM_CELL_DN There are 69 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SLC39A8 Weight Factor: 1.286 Major Gene (NEG): CAT Weight Factor: 1.108

NEG ALL Major Gene (NEG): CAT Weight Factor: 1.414 Major Gene (BCR/ABL): SLC39A8 Weight Factor: 0.86



TJP2 CTDSPL PIP5K1B ● OXT NFIB ● ● ICAM4 ● RALBP1 PTPN11 ACTN1 ATP1B1 ● IFI16HSPA1A ● PSEN2 ● ● ●● MECOM PRDX2 GADD45A ARHGEF12 ● ● ● SLC39A8 TFR2 CAT MLLT3 TNFSF10 ● ● ● ● ● ● FHL2 NPR3● HSPB1 LIMCH1 ● ● ● ● ● SERPINE2 TAL1 HSP90B1 SUCLG2 DLK1COX7A2L TXNIP LAPTM4B ●● RPS6 ● ● CXCR4 CRYGD ● ● ● PLS3 MAL ● C1QBP ● ETV5 ● ICAM2 ● LSM5 SHMT2 RPS27 MARCKS ● ● ● ● CFH ● ● ● ● ● PMAIP1 ELF1 ● BST2 RPL35 TCF25 ● AKR7A2 NDN TAX1BP3 ● ● PHYH ● ●UROD GRK5 CEBPB ● ● ● ● ● ● ALDH6A1 ● MAFF ● IL1BACTR2 RPL36A SRGN CKS2 ● ● HMGB3 ● RGS2

●

● ●

KHDRBS3

●

●

●

●

HSPA1A IL1B● PIP5K1B TNFSF10 ●MARCKS IFI16

● RALBP1 ● AKR7A2 ●● HSPB1 ICAM2 TJP2 ALDH6A1 HMGB3 ● ACTR2 ● BST2● CAT ATP1B1 ● PHYH ● MLLT3 ● PRDX2 C1QBP TCF25 ● ● ● ● ● ●LIMCH1 UROD ACTN1 MECOM ● ●LSM5 SHMT2 ● PLS3 CKS2 RPL35 ● GRK5 PTPN11 ● ● RPL36A SUCLG2 ● MAL ● ● ● ● RPS6 ● ● HSP90B1 ● ● TAL1 ● SERPINE2 ● TFR2 ● ARHGEF12 ● ● COX7A2L RPS27 ICAM4 ● OXT ● ●LAPTM4B CTDSPL FHL2 ● ETV5 ● ● ●CFH ● ● DLK1 PSEN2 ● ●NFIB ● TAX1BP3 ● ● GADD45A ● ● KHDRBS3 PMAIP1 ● ● TXNIP CRYGD NPR3 ● ●

●

● CXCR4ELF1 ● SLC39A8 MAFF RGS2 ● CEBPB ● ● ● ● NDN SRGN

● ●●

Pathway: AKL_HTLV1_INFECTION_UP There are 23 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NME1 Weight Factor: 1.523 Major Gene (NEG): NME1 Weight Factor: 1.523

NEG ALL Major Gene (NEG): NME1 Weight Factor: 1.457 Major Gene (BCR/ABL): NME1 Weight Factor: 1.457



LGALS1

●

S100A10 MAP4K4 ● SAT1 DFNA5 ●

LGALS3

●

●

● ●

CBX1

●

ACLY

●

●

ADD2

APP

●

●

ALDOC GNAI1

●

●

●

AP2B1

DNAJC7

●

RAB4A

●

SOX4

●

IDH2HSD17B8

LGALS3

●

ADD2

●

SAT1

●

● MAP4K4 NET1

S100A10

● ●

● ●

DNAJC7

●

NME1

●

IDH2

●

●

●

● VAMP8

NME1

● SOX4

FABP5 VAMP8

●

●

● ●

LGALS1

DFNA5

FABP5 HSD17B8

●

ACLY

●

●

NET1

AP2B1

●

RAB4A

CTNNA1

●

CBX1

APP

●

GNAI1ALDOC

●

●

CTNNA1

●

Pathway: RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP There are 65 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IL8 Weight Factor: 1.468 Major Gene (NEG): CD55 Weight Factor: 1.363

NEG ALL Major Gene (NEG): CD55 Weight Factor: 1.481 Major Gene (BCR/ABL): IL8 Weight Factor: 1.223



ITGAM DDX17

MFN1

● MNDA LY96 LTF ● AHNAK ● SWAP70 ● CSTA ADAM28 ● ● ASAH1 S100A8 ● NOTCH2 VNN2 GRK5 ● ● ● ● ITPR3 ● ● FOLR1 PTPRC ALAS2 GTPBP1 ● P2RY10 GPR183● ● ● ABCA1 ●IL13RA1 ● DUSP4 TCF25 ● MAP3K8 ● G0S2 ● IDS ● ● SLC7A5 ● ●BIRC3 MAX ● ● CA1 ● ● ●IL8 CREM IL1R2 SEL1L3 ● DEFA4 NR4A2RGS13 ● ● GABARAPL1 ● ● ● RGS2 ● MFN1 KLF9● DIDO1CH25H LY86 ● IFNGR1 ● GPR18 ● ●CEBPB EZR ● ● ● DUSP5 CD55 ● GPR65 ● AREG ● TXNIP ● CYTIP ● ● ZNF165 IQSEC1 ● ● ● ● MS4A1 GLUL FOSL2 ● ● P2RX5 GLIPR1 ● AIM1 ● ● TRAPPC10 ● ●

●

●

●ALAS2 GABARAPL1 KLF9 AREG IL13RA1 TXNIP ● ● ● ● IFNGR1 ● FOSL2● CYTIP EZR P2RX5 NR4A2 ● ●CEBPB ● ●CREM RGS2 ● ● ● ● GPR183 AHNAK CD55 DUSP5 SLC7A5 ● PTPRCMAP3K8 ● ●MS4A1 ITGAM RGS13 ● IL8GLIPR1 ● ● CH25H IL1R2 ● ● ●ADAM28 ● ● SEL1L3 ● ●● ● GRK5 TCF25

BIRC3 ● IQSEC1 ●GPR18 GLUL LY86 ● VNN2 GPR65G0S2 ● ● ● ●● ● ZNF165 ● P2RY10 AIM1 ● ● NOTCH2 CA1 LY96 SWAP70 ● ● ● ITPR3 ● ● DEFA4 S100A8 ● ● ● ABCA1 GTPBP1 ASAH1 LTF ● ● TRAPPC10 IDS ● ● MAX ● ●● ●DDX17 ● MNDA DIDO1 CSTAFOLR1DUSP4 ● ● ● ● ● ●

Pathway: MULLIGHAN_MLL_SIGNATURE_1_DN There are 184 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HYAL2 Weight Factor: 1.548 Major Gene (NEG): NOVA2 Weight Factor: 1.44

NEG ALL Major Gene (NEG): NOVA2 Weight Factor: 1.596 Major Gene (BCR/ABL): HYAL2 Weight Factor: 1.446



LRP6 CYP2E1 TPD52 STAT5B GABRE ● TNPO2SOX11 MAF SMYD2 ● NUP50 ● ● PPL IFIT1 CETP CD200 RQCD1 ● FDFT1 ● ●TSHR RBPMS HPGDS ● SLC13A3 ●SLC7A1 SLC12A4 ●● ● RUNX1T1 DPT OPN1SW CD1E FAM171A1 MCF2L ●● ●●MMP2 FUT2 FAHLHFPL2 ● ●● PTH2R SMARCA1 ●KIAA0913 ●ATP2C1 ●●MAPRE2 BARX2 NR2F2 ● ●● PYCR1 NOVA2 ● ● NPR3 DAPK1 CDH16 ● ● EPS15 ● ● RUNX1 TAL1 ● ●● ●ITGAV ● PBX2 AQP4 BIN1 ● SYDE1 ● ● ELMO1 ● ●HPGDP2RX3 TBXA2R TIMP3 ● ●● ● ● ● JAK1 FCER1A ● TTC3 SLC18A2 ● NET1 FSCN1 SSX1 ● MPL ● UBE2E1 ● HSPB2 APP ● ● TGFB1I1 ● HLF●ADK WASF1 ZMYND8 ● EDN2HYAL2 MYH11 ● TMEM5 ADNP2 ● NPM1 METAP1 ● BCR AGRN ● ● ● HOXB2 ● ● SLC9A3R2 ● TRMT1 ●CD99RPL31 ● BTN3A3 TRH ● SRP72 ●●●LARP4B ● ● RPS21 CA4 ●CEP170 TREH PGF ● ● ●● SRC ●CKB ●● HSF4 TSPAN7 ●BCKDHB SIPA1L1 CLMN SEPT11 ● ● ST18 ● ● ● TIE1 ● HS2ST1 ● DCUN1D4 ●LAMA5 ●CTDSPL HGF ● CCNG1 ● ●● AP1B1 PTRF POU4F1 STAM SPRY1 ● ● ● EEF1D● ● GGT5 USP34 ● RPP40 ● ● ● AREG ● PRF1 ● PTPN14 ● LUZP1 ● ● ● JUND NBL1 ● STAT5A ● BAIAP3 ●● ● IFI44 ● CHD1L ● CLIP3 ● KATNB1 ● ABCC4 ● ● PTPRCAP PPP1R16B MUC4 CIR1 TFPI ●CAV1NID2 ADRM1 ● ZNF274 PMAIP1 ●● MAST4 ● ●● ●●● ATP1B1 ●ATP2A3 KRT18 ● ● YES1 MDK ● ●●● ● CD3D TRIM16 ● ●DLC1 ● BTG3 ● TEAD4 ●●IL2RA● STAT4 ● PTGIR RASL10A ● TNFRSF21 PTP4A3 IL8 POLE ● LAMB2 DLEU1 ● ● STOM ● ITM2A BCAT1 ABCB1 ● TRIM24 ● TM4SF1 ●MYH10 ● ● ●● IFITM1 PITPNB RHOB ● CXCL2 ●BRD8 ● ● ● LOXL1 ● SERPINE2 ●● ● CHI3L1 ● ●●●MLL ●● EGR3 RANBP2 ● ● PRKCQ ●

●●● ●

●

TBXA2R SLC18A2 ITGAV HOXB2 ●FAM171A1POU4F1 FCER1A LRP6 ATP2C1 RPS21 MUC4 IL2RA PTH2R ●FUT2 TRIM24 ● ● TM4SF1 ● ● ●ADRM1 ITM2A ● ● ● SMYD2 ● AQP4 CAV1 ● ● NR2F2 CCNG1 ● ● CLMN RPL31 ●BIN1 PRKCQ CTDSPL MPL NID2 ● PTRF SMARCA1 ● ●RUNX1 LHFPL2 ●●EEF1D AGRN TRMT1 ●RASL10A ● TSPAN7 ● ● ● CD99 SERPINE2 ● CD1E ● PITPNB ● ●● ABCB1 RBPMS ●PBX2 CD3D ●● ● RUNX1T1 ●PPL STAT4 HLF ● TAL1 ●NBL1 ●●STOM SPRY1 PRF1 ● CHI3L1 ● ABCC4 ● ● ● HPGDS NPM1 ● AREG ● JUND ● ● LOXL1 ●● PMAIP1 BAIAP3 ● BARX2 NPR3● ● ● ● YES1 TSHR ● GGT5 CD200SIPA1L1 ● ●TRIM16 ●TEAD4 ●RANBP2 ● PTPRCAP STAM MAPRE2 DLEU1 ● MCF2L ● ● ● ● FAH PTP4A3 ● ● ●CYP2E1 ● GABRE LAMA5 ●UBE2E1 ● SOX11 IL8 MYH10 MLL ATP2A3 ●●TPD52 ● IFITM1 ADK ● ● DLC1 STAT5A ● ● CDH16 ● BRD8 CEP170 BTG3 IFIT1 ● ● TGFB1I1 ● CHD1L ● HYAL2 DCUN1D4 ● ●● ● ELMO1 FSCN1 EGR3 ● ● ● HS2ST1 BCKDHB IFI44 SLC13A3 ● ● ● ZMYND8 SRP72 ●APP ●FDFT1 ●NOVA2 CKBCXCL2 TNPO2 ●TMEM5 ● ●POLE ●●● ● ●MMP2 TIE1 ●KATNB1 ADNP2 METAP1 RPP40 BCAT1 TREH ●● ● CA4 SLC12A4 ●KIAA0913 ● MYH11 ATP1B1 ● ● NET1 ● ● SLC7A1 TNFRSF21 ● ● STAT5BCETP ●● HSF4SYDE1 ● ● OPN1SW ●PPP1R16B ●● ● ● LUZP1 EDN2● ● ● ●●●● MDK LARP4B SSX1 ● ● HSPB2 PGF KRT18 ●SEPT11 NUP50 ● ● ● WASF1 HPGD LAMB2 CIR1●P2RX3 ●SRC ●● TIMP3 ● ● SLC9A3R2 CLIP3 ● ● PTGIR MAST4 RHOB ● USP34 BTN3A3 ● ● PTPN14 ● ● ● BCR ●JAK1 ● TTC3 ● ●● ● TFPI ● DPT ● ● ● RQCD1 ● ● DAPK1 ● ● ● ● ● ZNF274 ● ● AP1B1 TRH ● ● PYCR1 ● ST18 EPS15 ● ● ● MAF HGF

●●

●● ●

Pathway: MULLIGHAN_MLL_SIGNATURE_2_DN There are 221 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): EDN2 Weight Factor: 1.505 Major Gene (NEG): ASS1 Weight Factor: 1.264

NEG ALL Major Gene (NEG): ASS1 Weight Factor: 1.579 Major Gene (BCR/ABL): EDN2 Weight Factor: 1.534



NONO GTPBP1 NR2F2 MMP2 NPM1 SCN2A ANKLE2 SUPV3L1 ● ● RQCD1 COPG2IT1 CLMN LGR5 HNRNPA1 ● ● ●LRRC8B CSN3 BARX2 ITGAV ● SLC7A1 CYP4F2 ● HMGN4 KHDRBS1 CD1E CETP CDH4 NPR3ZNF85 ● TRH ● ●SEPT9 ● ● ● AP1B1 ●● ● SYNCRIP ● ● NTRK2 DPT ●●UBE2E1 HPGDS ●● ●● CD96● USP34 ● ● CD99 ● HINT1 EEF1D CD200 CCNG1 ● ● ●●PYCR1 ● RUNX1T1 RASL10A RAB11A ● ● MATR3 TNPO2 PTPN14 ● CDH16 ● PITPNB SLC12A4 ATP2A2 ● ● ● ● KTN1 DCUN1D4 SORL1 NAV3 AREG SPRY1 PPL ●CHD1L TCF3STOM KATNB1 SERP1 UBR5 KIFAP3 ATRX ● ● ● DUSP14 ● ● BCR DAB2 ● ● MLL DMXL1 ●● ● ● BRD8 ●● SEPT11 ●IFI16 HPGD ●●● LYRM1 PRKCH ELMO1 PDCD4 ●ASXL1 ● ● ASS1 IFITM1 PGF ● ● ● GALNT1 TSPAN7 ● ● ●ATP2A3 TNFRSF25 TM4SF1 ENDOD1 VGLL4 ● ●EPS15 ●ADK ●PTPRCAP NET1 HS2ST1 ● ● RHOH PEX3 LEPROTL1 ●● ● ● ● ●PTRF MACF1 MDK PTHLH ATP2C1 ● SERPINE2 CLIC4 ● POLE KLRK1 ACACA ● GLS ● ● ● ● BTN3A3 ● PTP4A3 ● ● ● MAST4 ● ●ITM2A JAK1 CYP2E1 ●PMAIP1 ●● BCAT1 POU4F1 ● ARAP2 ●●●●● DNTTIP2 ● RBPMS ●EDN2 ● ● ● FSCN1 TFPI ● ABCB1 NBL1 CKB ST18 H1F0 ● ● NEDD4 ● PTGIR TIE1 SIPA1L1 YES1 ● ● ● IL2RA ● MPL ● MCF2L ● LGALS3BP BTG3 ●IER2 FDFT1 ●● METAP1 KDM5B ●RPP40 DHRS3 ● ● ●PPP1R16B MAPRE2 ● ● ●●PRKCQ ●● ●SRC RANBP2 ●ICOSLG DBN1 CEP170 ●●HIF1A TRIM24 STAT5B ● ●DAPK1 ● ● CTDSPL ● MN1 STAT4 ● ● MUC4 STAM ● TGFBR2 N4BP2L2 SPARC ●● MSMB● ● ● ● BAIAP3 SLC9A3R2 SLC18A2 ABCC4 TRMT1 CXCL2 EGR3SRI● ●APP ● LAMA5 ● CD34 ●●RALGDS ●● HYAL2 ●● LHFPL2 ●FAH ●TBXA2R FAM171A1 STAT5A IL8 ●SMYD2 ●●●CHI3L1 ● ● ●PDIA5 ● OLFM4 ●P2RX3 ●RPS6KA2 LUZP1 ● ● LAMB2 ● ● ● ● ● GGT5 TTC3 ● NME4 ● ● ● AGRN ● ATP1B1 FGFR1 ●● TPD52 ●TNFRSF4 ● ●IFI44 ● ● ● ●RUNX1 TGFB1I1 ● ● LOXL1 TRIM16 MAN1A1 ●LRRN2 ●● WASF1 ● MYH11 ● ● ● ADRM1 ● B4GALT6 ARFGEF1 ● DLEU1 ●● TNFRSF21 ●●●TEAD4 NUP50 ●● ● ● ●● HGF ●● ●● ● ● PRF1 CD3D

●

●

LEPROTL1 HGF BRD8MN1 B4GALT6 ATP2C1SORL1 UBR5 ● VGLL4 ● TRH TTC3 ● ● KIFAP3 PTRFMATR3 ELMO1 ANKLE2 ● ARFGEF1 RQCD1 ●YES1● DPT IFI16 ●CYP2E1 ●●● MAST4 KDM5B SCN2A SLC7A1 ●CD96 TNPO2 ●MACF1 ● ● HMGN4 MAPRE2 FDFT1 ●ZNF85 DCUN1D4 METAP1 LUZP1 ● DMXL1 PEX3 ● ATP2A2 LAMA5 TNFRSF21 ● ● CDH16 ● MAN1A1 ● ● IL2RA WASF1 ● ● CSN3TEAD4 ●●SRC ● CHD1L ●BAIAP3 ● BARX2 ● ● DLEU1 RBPMS SLC18A2 PTGIR ● KLRK1 ● KTN1 ●●●●SRI ● MMP2 ● ● P2RX3 ●TNFRSF4 ●● ● ●●HINT1 PPL TGFB1I1 NAV3 EDN2 PTPN14 MSMB HPGDS ●PYCR1 TPD52 ●EPS15 ● ● LYRM1 TNFRSF25 ●NEDD4 ● STAT5B ● CKB ● MYH11 ● GTPBP1 GALNT1 ● MPL ● ● ● ASS1 ●PDCD4 ITGAV ACACA CEP170 LAMB2 SLC12A4 CD200 GLS ● ● ● KHDRBS1 ● PGF ● ●UBE2E1 ●● ●LOXL1 ●DUSP14 ● ● HS2ST1 RUNX1T1 CETP ASXL1 ●●● ● SERP1 ●NPM1 ● ● ●● TRIM16 NONO● COPG2IT1 ● MCF2L N4BP2L2 ● ● ●CD1E CDH4 ● BTN3A3 ● HPGD ● SLC9A3R2 RALGDS TRIM24 ● CYP4F2 OLFM4 ● ● ● NBL1 TIE1 ICOSLG ● ATP1B1 ● TGFBR2 DAPK1 ● ADKJAK1 ● ● ●● SERPINE2 ●●NR2F2 ●● ●EGR3 HYAL2 APP ● ●BCAT1 ● ●● ● SEPT11 ●●EEF1D ●● FGFR1 ● SYNCRIP RASL10A AGRN PTHLH ● LGR5 ● ● ● KATNB1 CLIC4 NTRK2 ● LRRN2 ● ● GGT5 SIPA1L1 ● ● ● USP34 RHOHHNRNPA1 ● MLL ARAP2CHI3L1 POU4F1 ●● ADRM1 ● ●AP1B1 ●DAB2 ● ● ATRX SEPT9 LRRC8B ● ●PPP1R16B MDK PITPNB ●● ●PRKCQ ●●●RPP40 ST18 ● ● ●PTPRCAP AREG ● ● RAB11A ●CD34 HIF1A PMAIP1 ● ● ●PRF1 ● SUPV3L1 FAH ●TSPAN7 ● ● ● NUP50 ● ● CD3D ● NME4 ● TFPI ABCC4 ● IER2 ● ● POLE DNTTIP2 ● ● ● ● PDIA5 NPR3 FSCN1 ●● ● ENDOD1 SPARC ●● ●STAT4 ●LHFPL2 ● CCNG1 ● ●ATP2A3 BCR H1F0 ● IL8 ●TRMT1 ITM2A LGALS3BP ● SPRY1 ● ● CD99 ● ●●● TCF3 ● PTP4A3 ● NET1 ● RPS6KA2 ● DBN1 TBXA2R ● ● TM4SF1 CTDSPL ● FAM171A1 ABCB1 ● CXCL2 ● ● ● DHRS3 PRKCH ● BTG3 STAM ●● STOM RANBP2 ● ● ● ● STAT5A ● IFITM1 ● ● ● MUC4 RUNX1 ● ● ●● ● ● ● CLMN IFI44 ● ● SMYD2

●●

●

Pathway: TIEN_INTESTINE_PROBIOTICS_6HR_DN There are 121 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): N4BP1 Weight Factor: 1.529 Major Gene (NEG): PICALM Weight Factor: 1.272

NEG ALL Major Gene (NEG): PICALM Weight Factor: 1.57 Major Gene (BCR/ABL): N4BP1 Weight Factor: 1.155



SPATA2 DOCK9 SEC23B SPON1 HEXB MELK SUCLA2 ● CENPA ID2SGK1 BAMBI PDZK1 ●CAP2 ● LARS2 CADM1 ● ●MAP3K4 ● ●SLC19A2 ● SGMS1 ● ● LRPPRC EAPP● MSX2STEAP1 ● ● ● CALD1 ● ACTN1 SMPDL3A PACSIN2 SLC7A6 ● FHL2 ●● KIDINS220 RNF5 ● ●ADSLNDUFA9 ●● ● ● WWTR1 ● ●● PITX2●PLCB1 ●●IQGAP2 TRIM37 TAX1BP3 MRPS14 TJP1 ● ● ● ● MICAL2 SEC14L1 ●MPRIP SPAST ATP2C1SRP19 UBE2D1 AIMP2 ● AMOTL2 ● ●CDC42EP3 ● GYG2● ● ● EMP2 CKAP4 RBMS1 IL1R2● ● CTR9 ● ●●UPP1 PICALM ● ●INPP5F● ● APODMTRR CASC3 ● ●SEPP1 RCHY1 ● ●RIN2●TEAD4 CEBPD ●PSMD1●RECQL ●● ● STX3 DNAJB9 FERMT2 PSMC1 ● ● ● ● PPP2R5A ●DHX29 ● DBN1 ● DDX1 ● ● QKI TCF4 SMYD2 ● ● N4BP1 ● ● ●TMPO ● KIAA0317 FXR1 ● ● RYBP ● ACOT13 SAMM50 ● ● RAPGEF2 ● BRD8RDBP ● ● MMD CETN3 PSME4 ● RDH11 KIN ● ● CRIM1 TSC22D1 PPM1B ACAA2 ● ● GAB2 ●TTC1● DGKD ● ATP6V1D ● ETF1 MCM5 ●● ● ADM ● ● ● ● ●PTS BTG1 EIF1B ● RAD50 TSG101 ANXA6 MAPK6 SRRT ●● ●●● NDUFA6 ● ● CELF1 ● ●● ● TAF9 ● SNW1 ANP32E CIRBP

● ● ● ● ●● RAB9A

●

PPP2R5A MICAL2 ACAA2 CAP2 SPATA2BTG1 ● ● SEC14L1 FERMT2 ● UPP1 ● ● CDC42EP3 CIRBP ETF1 ●CELF1 MAPK6 ●● WWTR1 PSME4 ● PTS ● TSC22D1 ● ● ●ADM HEXB ●RAB9A DBN1 ● ● TAF9 SMYD2 ACTN1 ●PLCB1 TMPO ● ● GAB2● ● NDUFA6 EIF1BSRP19 ● ● SEPP1 MMD ● ●DNAJB9 PSMC1MCM5 UBE2D1 ● ● ● ANP32E ● SPON1 DHX29 SGK1 PDZK1 ● ●RAPGEF2 RNF5 ● DOCK9 ● PPM1B ●SNW1 ●PACSIN2 RYBP ● ● RDH11 LARS2 ● ID2 ● ●● ● ●MELK LRPPRC ● ●● SRRT ● ANXA6 ● SEC23B ATP6V1D GYG2 ● TSG101 ● KIAA0317 CEBPD ● IL1R2 ●SPAST ● PICALM SMPDL3A CASC3 CETN3 ● ● DGKD TTC1 ● ● ● CKAP4 ● MRPS14 RAD50 N4BP1 SGMS1 TJP1 ●● ● ●● MSX2 ● ● CRIM1 ● ● SUCLA2 ● RECQL ● KIDINS220 DDX1 ● ● RCHY1 ● ● MAP3K4 FXR1 FHL2 ● ● SAMM50 ● RIN2 ● AIMP2 ● ●TCF4 ●PSMD1 KIN ACOT13 ● ● ● BRD8 MTRR ●BAMBI ●TRIM37 ● ●QKI ● CENPA RBMS1 IQGAP2 ●● AMOTL2● ● ● CTR9 INPP5F ● ● ●● ● TEAD4 ADSL CADM1 ● PITX2 ● ● ●ATP2C1 RDBP ● ● ● ● NDUFA9 EMP2 STX3 SLC7A6 ● ● ●APOD ● ● ● ● STEAP1 ● SLC19A2 MPRIP ● CALD1 TAX1BP3 ● EAPP

●

●●

●

Pathway: ELVIDGE_HIF1A_TARGETS_UP There are 47 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MRPS12 Weight Factor: 1.372 Major Gene (NEG): CHUK Weight Factor: 1.182

NEG ALL Major Gene (NEG): CHUK Weight Factor: 1.324 Major Gene (BCR/ABL): MRPS12 Weight Factor: 1.047



CXCL12

HSPA4

● PSEN2GABBR2 SLCO3A1 ● ● RRP15 ● SOCS2 IDH3A ● CCDC86 ● CCND3 URB2 ● HSPA4 ● ● SLC29A1 AMD1 ● RAB35 ● SLC5A6 ● SEC23IP● KPNA1 SLC7A6 ● SRM ● ●MRPS12 ● ● ● PSME3 RRS1 HSPH1 JAK2 CORO1A RPP40 ● KIAA0317 ● ● HHEX● DOLK ● ●LARS2 ● WDR77 CHKA GYG1 ● GULP1 ●CHUK ● ● SLC25A44 STX3 ● ● ● ● ATP6V0A2 ● SLC35B1 DNAJA1 ● ABCF2 ● ● ● RFK GCH1 RRP12 ● ● ● IDE

●

SPAG1 PNO1

● ●

CXCL12 SLC35B1

●

●

●

KIAA0317 SLC5A6

●

SLC25A44●

●

PNO1

●

●

IDE CORO1A SOCS2● CCDC86 GYG1 ● ● ● ● ATP6V0A2 AMD1 CCND3 HHEX ● STX3 ● LARS2

● ●CHUK HSPH1 ● ● MRPS12 ● ● ABCF2 SLCO3A1 DNAJA1PSEN2 CHKA GABBR2 ● ● ● IDH3A ● ● ● ● URB2 GCH1 ● ● SLC7A6 ● ● RAB35 KPNA1 GULP1 DOLK ● ● RFK ● ● JAK2 ● SPAG1 ● PSME3SRM ● SLC29A1 ● ● ● RRS1 ● SEC23IP RPP40 RRP12 ● WDR77 ● RRP15 ● ● ● ●

Pathway: ELVIDGE_HIF1A_AND_HIF2A_TARGETS_UP There are 29 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FLAD1 Weight Factor: 1.425 Major Gene (NEG): CHUK Weight Factor: 0.968

NEG ALL Major Gene (NEG): CHUK Weight Factor: 1.262 Major Gene (BCR/ABL): FLAD1 Weight Factor: 1.109



GABBR2

RET

●

● CCND3

CCND3 CORO1A GYG1

●

●

●

RET ● ATP6V0A2

●

CHKA

●

●

●

●

SLC29A1

RRP12 RRS1

●

●

SOCS2 ● CCDC86

●

●

●CCDC86 ●

FLAD1

STX3 HSPA4 GCH1 SPAG1 RPP40 RFK SLC35B1 ● ● CHKA ● WDR77 ● ● ● ● ● SLC25A44 ● KIAA0317 HSPH1 ● CHUK ● FLAD1 ● SRM SLC5A6 ● ABCF2 ● ● IDH3A

SLC35B1

●

●

WDR77 GYG1 ● RFK

● RPP40 RRS1●

●

●

●

SLC25A44 ● ABCF2

●

GABBR2 CHUK

GCH1●

SRM

CORO1A

● SOCS2 SLC29A1

●

●

●

SPAG1

RRP12

● STX3

●

ATP6V0A2

● HSPH1 KIAA0317

●

●

●

HSPA4IDH3A

●

●

● SLC5A6

●

Pathway: JAATINEN_HEMATOPOIETIC_STEM_CELL_DN There are 168 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FCN1 Weight Factor: 1.534 Major Gene (NEG): FGR Weight Factor: 1.452

NEG ALL Major Gene (NEG): FGR Weight Factor: 1.468 Major Gene (BCR/ABL): FCN1 Weight Factor: 1.183



TFDP1 LY9 ● HBZ MYL4 ZNF384 SNTB2 CD5 DOCK9 ● ARL4C DOK2 ● KRT1 KLF1 FCGR3B BLVRB ● HBB ● ● CTTNTXNIP CAMK4 SGK1 ● ● HBD ●KLK8●● LRRN3 ● ● IGF2R MMP8 ●BPGM ● SELENBP1 ALAS2 ● SLC4A1 ● ● ● CDK5R1 XCL1 ● CCR1 ●● ● RHAG KLF4 RHD ● ●● ●SGSH ●●● ● CITED2 ● ●ISG20 MAN1C1 F5 SLC14A1 CD36 PF4V1 ● IL7R GYPA ACSL6 LEF1 ●GABARAPL1 THBS1 PLXDC1 XK● CTSB ● GPR18 ● CA1 FPR1 ● CYP1B1 ● CD163 LGALS3 ● FAM102A ●GPR65 ● CD28 ●● ●● ● ● MARCH2 SERPINB2 CTSE BCL2L11 CLEC10A ● ● ARG1 ● MYBL1 IL1RN ● ● PCSK5 ● UPP1 PPBP ● ● OLFM4 ETS1 MMP9 ●● ITGB2 PASK ● QPCT ODZ1● IL13RA1 PRKCA SNCA ●● CD86 KLRK1 CHI3L1● ●● ● ● STX11 ●ZER1 SLC2A3 ● ● ● ● ● NID1 ● LTF●●S100A8 ● ● CD14 ● ●CCR7 ● ● LCK S100A12 TRAT1 ● CTSH ●● MALAQP3 ● RASGRP1 NELL2 PF4 KCTD12 ● CEACAM8 ● FCN1TOB1 ● ●EPHA4● ZFP36L1 IL10RA ● CDKN2D ● CD1D NCF2 ● ● ● ● ●● STK17A ● ZAP70 S100A9 ● ● IL18RAP FCER1G ●● ●PSAP ● MNDA ● PTGDR ● ●LGALS2 KLRB1 CD247 CEBPD CSTA ● F13A1 ITK SERPINA1 CD2 TGFBR3 FYB ● VCAN RTN1 ● ●IGSF6 TYROBP ●TNFAIP3 ●IFI30 ● ● TGFBI RGS1 RORA ● ● ● ● ●CCL5 CD8A ● ● ● ● CD3D ● ●FGR IL2RB SECTM1 ●●CYBB ●TUBB2A CCL4 ● ITGAM ● CALD1 ● ● ●● ● ● ●FGL2 CPVL CD27 ●● ● CX3CR1 ●HCK ●● GNLY NKG7 GZMK ● ● ● PNP ● GZMB GZMA TRBC1 FCGR2A ● ● ● PRF1 ● ●● MEGF9 ●● ●● ●● GZMH CD8B ● CST7 ●

●

●●

ACSL6 MAL PLXDC1 MAN1C1 ● CD5 DOCK9 NID1 ● CD163 ●CDK5R1 SNTB2 PCSK5 ● CD28 CEACAM8 ● ● ●CD36CHI3L1 ● IL1RN ● CA1 HBZ CALD1 MYL4 KLF4 ● ● CLEC10A ● SLC14A1 ● QPCT RORA ● LRRN3 ● EPHA4 MEGF9 ●● XCL1 ● ● LTF ETS1 ● ● TGFBI LEF1 OLFM4 CCR1 ZNF384 ●● ●PF4V1 ● SERPINB2 CYP1B1 ARL4C ● ● ● CTSB DOK2 FAM102A ● ● KLK8 ● RGS1 ● PSAP ZFP36L1 FCGR2A ● PASK CITED2 THBS1 ● UPP1 CTTN ● IGF2R CD14 ● ● MMP8 ● ● FPR1 ● ● ●● ● RTN1 ●TRAT1 ● CD8B ●RASGRP1 STK17A ● ● ● ● ● KCTD12 ●● ● F5 ● CCR7 ● STX11FGL2 ● CDKN2D ● ITK ● PRKCA GABARAPL1 MMP9 MNDA TNFAIP3● ● ● ODZ1 PTGDR GPR18 S100A8 ●SNCAIL10RA ● BCL2L11 CD247 IL13RA1 ● SECTM1 ● S100A12 GPR65 ● ● TRBC1 CD27 ● VCAN ● SGK1 ● ● ● ● ● ● ● TOB1 ● CSTA CEBPD ● ● TXNIP IL18RAP PF4 KLRB1 CD2 ● CAMK4 ● ● ● CD3D ●CTSH● ● NCF2 FGR ISG20 S100A9 HCK PPBP FCGR3B MYBL1 ● ●SGSH ● TYROBP FCN1 ●TGFBR3 ● IL7R ● ●● ● CCL4 ITGAM PRF1 GNLY ● FCER1G ●LCK NKG7 IFI30 SLC2A3 ZER1 MARCH2 ● ● ● ● ● CX3CR1 IL2RB CD86 SERPINA1 ITGB2 ● CPVL ● CD1D FYB ● ● ●IGSF6 ● ●GZMH ●● ● GZMB ● ● ● ● ● ● ● LGALS2 CCL5● ZAP70 ●● ● ● ● ● ● ●● ● ● ● CD8A CST7 AQP3 NELL2 GZMA ● ● KLRK1CYBB ● LY9 ● ● GZMK KLF1 ● ●●● ● ● KRT1 TUBB2A ● ● LGALS3 ALAS2 ● ●ARG1 ●● F13A1 SELENBP1HBD BLVRB HBB ● ● SLC4A1 ●BPGM ● ● PNP● ● ● TFDP1 RHAG RHD ●GYPA ● ● XK CTSE

● ●● ● ● ●

Pathway: RODRIGUES_THYROID_CARCINOMA_DN There are 53 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ZMYM2 Weight Factor: 1.475 Major Gene (NEG): LIF Weight Factor: 1.367

NEG ALL Major Gene (NEG): LIF Weight Factor: 1.559 Major Gene (BCR/ABL): ZMYM2 Weight Factor: 1.267



DUSP10 RIT1

●

●

UBXN7 THBS1

●

●

ARHGAP29 PCBP2

●

ARHGEF7 ANKRD28

● ATXN1

● ● QKI ● CREB5 TAB2 ● ● ● ● ● S100A10 CDK6 CDC42EP3 SRGN BBC3 ● ZMYM2 ● CD44 ● DMD ● ● ● ● PLCB1 ITGB8 SHANK2 ● ALCAMNAMPT ROBO1 ● ● ● UGCG ● AREG ● ● DICER1 ● ● MAP2 THBD EFNA5 ● F2RL2 ● AMIGO2 ● LIF ● ● CXCL1 FN1 DCBLD2 HIPK2 ●● PTPRK PLEC ● ● ● ● PAX8 TRA2A ● ● ZNF160 S100A2 HIVEP2 MYO1D ● ANK3 ● KCNMA1 ● ● ● ZNF638 ● ● BBX ● ● ● IRF1 MORF4L2

CDK6IRF1 ZNF160 ● ● PLCB1 BBC3 ●AMIGO2EFNA5 ● DCBLD2 ● ANKRD28 THBS1 UGCG ● ITGB8 ● ● CXCL1 ● ● HIPK2 ● ● ANK3 LIF DICER1 CD44 ● ● MYO1D ● ATXN1 ● ● ● ZMYM2 PLEC ● FN1 ● TAB2 ● HIVEP2 S100A2 ● ● ● DUSP10 ARHGEF7 ● DMD S100A10 ● BBX PAX8 AREG ● ●● ● NAMPT ● ZNF638 ● UBXN7● QKI TRA2A ● KCNMA1● ● CDC42EP3 RIT1 THBD ● ● ROBO1 ● ● MAP2 SRGN ● ● PCBP2 ● ● ● SHANK2 MORF4L2 ALCAM CREB5 PTPRK ● F2RL2

●

● ● ● ARHGAP29 ●

●

●

Pathway: HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP There are 131 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): WBSCR22 Weight Factor: 1.452 Major Gene (NEG): UPF2 Weight Factor: 1.438

NEG ALL Major Gene (NEG): UPF2 Weight Factor: 1.624 Major Gene (BCR/ABL): WBSCR22 Weight Factor: 1.52



TXNIP TRAK2 CASP1 SLA FOXO3 IGFBP3● ● TNFRSF1A ● ● NUDT1 GMFG CD52 STOML2 ● LY86 RPL23 GPIPSMB3 ● ● ● ● ● ●● ● SNCA ● DAB2TM4SF1 ANXA11 MED13 SMS IL7R ● FLNA ● PPIH ● CAPZB ITM2A ITGB1BP1 ETHE1 PFN1 ● ATG12 CREB3L2 ● ● SART3 ● ●RPS21 SSR2 PDIA4 ● ● TSC22D3 ● P4HA1 ● ● PPIB ● MFAP3 RBBP4 ● ● FXR1● ● ● MGAT2 CCL19 ● MARCKS LST1 ● HNRNPA1 ELAVL1 ● YWHAZ ● GLUD1 SHOC2 ● ● ●GSN ● ● ● SP3 ● RECQL ● BARD1 CTBP1 GCA TCF4 CASK ● ●APEX1 CNN3 DENND5A RPN1 ● ● ●HNRNPU ●● ●LDB2 ARF5CTSH ● ZNF22 ● ●ARPP19 ● CCDC85B ITGB3BP ● ● ● ●● ERH ● SOX4 ● PTPRO WBSCR22 ●● ●TRIM2EIF1 SEMA5A LRRC15 CIRBP ● SLC5A3 ●FBLN1 ● ZNHIT3 ● SRRM1 ● ●JUND VCAM1 CRIM1 ZNF292 MAP4K4 MPRIP CFH ● ● ● UPF2 ● SERPINF1 ● ● RGS5 NSL1 ● ● EIF3A● ● ●● ● TNPO1 NFIB ●●● ● ●● EAPP IFT20 ● NUAK1 ●NTRK2 CAPZA2 CLDN5 ● FEZ1 LIPT1 SPTAN1 ERG ● ● CPA3 ● ● ● ITPR1 ●SAFB NME3 ●PRKCI RCBTB2 SF3B1 ●DARC ●● TOX ● ● ARPC1A ●CCND2 SUZ12 ● GNB1 SAFB2 CALM1 ● ● ● ● ● ● ● ● HLA−DQA1 ● LAMP1 ● ● PWP1 ●SATB1 ● ARL3 HPGDS PDCD4 ● ● ●● SNRNP70 ●●RBM25 ●

● ●

ITM2A LST1 CASP1 ITGB1BP1 ANXA11 GSN ● ●MPRIP ● CTSH ● IL7R ●● CASK PTPRO SATB1 ● LY86 HNRNPA1 RPL23 ● ● FLNA CAPZB ● RPN1 MARCKS SEMA5A● CALM1 ● NTRK2 ● ● ● ●● CD52 SMS PDIA4 ● RPS21 MED13 ● ● ● PPIB BARD1 TNPO1 PFN1 NUDT1 ● ●SF3B1 ● ● SSR2 ITPR1 ● ATG12 ● ● ARF5 CIRBP ● SRRM1SHOC2 CLDN5 ● ●●● GMFG DENND5A GLUD1 SUZ12 ● ETHE1 ● P4HA1 ● PPIH ●CCL19 NUAK1 ● PRKCI ARPP19 TM4SF1 IFT20 ● ● ARL3 ●FEZ1 ● SLA PSMB3 STOML2 TRIM2 ● RCBTB2 ● RECQL ● CAPZA2 CCDC85B ●APEX1 ● ● ● LAMP1 GNB1 ERH ● ● ● RBM25 HPGDS UPF2 WBSCR22 ● ● ● ● ● ● ● EIF3A ●RBBP4 ● SNRNP70 ● ● TRAK2 ●● ● ●● ● FOXO3 MAP4K4 ● PWP1 ● YWHAZ HNRNPU ● DARC ●ZNF292 CFH ●SOX4SPTAN1 CREB3L2 ● GPI PDCD4 ZNHIT3 ● ●● ● ● SNCA TXNIP ● ● ● SAFB ●SAFB2 CCND2 TSC22D3 ELAVL1 ● ● ● RGS5 ● SLC5A3● FBLN1 ● NSL1 ● NFIB ● ● CTBP1 ●●IGFBP3 ●ARPC1A ● GCA TOX EIF1 ● JUND ITGB3BP LRRC15 ● ● LIPT1 ● ●● ● ● ● ● CRIM1● MFAP3 ERG ● HLA−DQA1 TNFRSF1A EAPP ● VCAM1 LDB2 MGAT2 SP3 ● ● ● ●CPA3TCF4 ● DAB2 ● SERPINF1 ●NME3 ● SART3 ● ● ● ● ● ● ●ZNF22 ● ● ●CNN3 FXR1

●

●

●

Pathway: GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_DN There are 20 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): WNT4 Weight Factor: 1.352 Major Gene (NEG): ELMO1 Weight Factor: 0.926

NEG ALL Major Gene (NEG): ELMO1 Weight Factor: 1.307 Major Gene (BCR/ABL): WNT4 Weight Factor: 1.194



GSTA4

NMT2

●

● ELMO1

SERPINB8

CPOX

DYRK3

●

●

CST6

● GPR19

●

GCH1 WDR62

● ● WNT4

WDR62

● SLC6A8

●

●

●

●

GSTA4 ETV1

●

●

●

●

CPOX

●

SLC6A8

CHST1

●

●

GCH1 PCK2

●

WNT4

●

CST6

RPS6KA2 PCK2

●

● ETV1 DUS4L

● AHNAK

●

ELMO1

●

● DUS4L RPS6KA2MTM1

●

●

CHST1

●

●

DYRK3 WHSC1 MTM1

●

●

●

WHSC1

AHNAK

● GPR19SERPINB8

●

●

●

NMT2

●

Pathway: OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP There are 112 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SNRPD3 Weight Factor: 1.353 Major Gene (NEG): H2AFZ Weight Factor: 1.253

NEG ALL Major Gene (NEG): H2AFZ Weight Factor: 1.366 Major Gene (BCR/ABL): SNRPD3 Weight Factor: 0.981



SLC25A5 ATP5F1 UBE2V2 HERPUD1 ACP1 ● ●TMED10 NDUFV2 RHEB ● ARF4 NUP153 ● ● PRKCD ● ● PTS●HNRNPU SDCBP PSMA3 SPINT2 ● CD47 SSR1 ●IFI30 ●UBXN4 ● SNRPB2 BTG3 ● ● DPM1 SLC35B1 ● ●● ● ● SDHB YWHAZ ● ● ●CAPG COX7B PSMB4 ● ●EFR3A SUMO1 HMGN3 ● ● DDX5 TUBB ● TPM4 ●NDUFS1 ●LDHA ● ATP13A3 PSMB2 KDELR2 ● UBA1 ●● ATP5C1 TNFSF10 ● CSNK2B ● ● IFIT1 PSMC6 ● MAL ● TARS ●● ● CKS1B ● MAPRE1 POLR2K ● PSMA2 ZNF146 SNRPD3 ● ● COPB2 ● ● TM4SF1 ● ● RAF1 ● RALY ●● CDKN3 ●RAD21 RFC4 NUP205 ●PTGS1 ATP1B3 PLSCR1 SRPK1 ● ● H2AFZ ● TCEA1 ● ● HMGB2 PRKDCLRPPRC CKAP5 ● ●CYCS NASP ● ● ● COPS5 B2M ● CSTB ● ● CFI ●●● MELK CKS2 CBX1 ATP5B ● CSE1L IARS ● ●● ● SLC35A2 ●NMIHMGN1 ● EPRS MDH1 ● ● ● ● CD9 YBX1 ● ● ● ● FH ● GNASPRKCI THAP11 MRPL3 ● MBTPS1 ●CTNNA1 PRSS8 ● ● ● ● PARP1 ● MAP2K1 ● HNRNPM ADAR ● ●● ● ●CCNE1 ●HNRNPD SUMO2 ● ● IFI44● ● RANBP1 SPP1 ●● OAT● GLO1 ●

● MEST

●

●

●

TNFSF10 NDUFS1 ADAR PSMA3 PSMB4 ● IFIT1 ●IFI44 NMI ● CYCS ● COPS5 ● CCNE1 ● RFC4 SLC35A2ATP5C1PSMA2 ● ● ● GLO1 TARS ● ● MRPL3 SPP1 CD47 ● ● ZNF146 PLSCR1 ● SNRPD3 CSTB COX7B MDH1 ● ● ●●EPRS ● ● PSMB2 LDHA THAP11 CKAP5 ● ● SRPK1 ● ●PRKDC ● ●FH● SSR1 MBTPS1 CSNK2B SDHB PRKCD ● IARS ● ● KDELR2 ● ● ● ● SPINT2 CAPG UBA1 ● ● YWHAZ ● ● CKS2 ● RALY CDKN3 CFI ●●●TCEA1 NASP UBE2V2 CSE1L PARP1 ATP5B● ● RAF1 ● ● ● ● POLR2K ● TM4SF1 ● ● ● ●RANBP1 ● ● COPB2 ●B2MBTG3 CKS1B ● MELKMAL● ● HNRNPU ATP1B3 HMGN3 ● PTGS1SUMO1 NDUFV2 CBX1 ●●● ● ● NUP205 LRPPRCOAT SUMO2 ● ● TUBB ● ● ● ● EFR3A ● ARF4 ● PTS ● PSMC6● H2AFZ PRKCI SNRPB2 YBX1 ATP13A3 ● HNRNPM ● HMGN1 RAD21 ● IFI30 ● MAP2K1 UBXN4 ● DPM1 ● ●●ATP5F1 ● SLC25A5 ● ● NUP153 ● ● HMGB2 ● SLC35B1 ● ●●● PRSS8 TPM4 MAPRE1 ACP1 ● ●CTNNA1 ● RHEB ●● HERPUD1 GNASMEST CD9 ● ● DDX5 ● ● ● SDCBP ●● ● ● ● ● HNRNPD ● TMED10

●

●

Pathway: MISSIAGLIA_REGULATED_BY_METHYLATION_UP There are 91 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IGF2 Weight Factor: 1.395 Major Gene (NEG): PRSS8 Weight Factor: 1.25

NEG ALL Major Gene (NEG): PRSS8 Weight Factor: 1.514 Major Gene (BCR/ABL): IGF2 Weight Factor: 1.483



TXNIPGADD45A

● MYRIP ● TIMP1 PON2 QPRT AREG MAP2K3 BCL11A

●● PSEN1 ● ● ● ● HIST1H2AC ATF3 ● SPINT1SLPI SERPINE1 BECN1 ● MAP1LC3B WFDC2 RARRES1 ● ● ● LY6E HIST1H2BK DUSP6 ● ● ● IFNGR1 IGF2 ● USP9X SLC6A8 ●BST2 LGMN CDKN1A● ●MFGE8● SDC4 ● UBE2H IL1B ● NEU1 ● BIRC3 ● STAT1 ● ● MFI2 ● ● TNFAIP3 ● PRSS8TAP1 ● CCL20 ● KIAA0247 ● CTSB ● ● ● ● RAB9A IGFBP3 DNAJB2 ● ● RNF103 ● COL1A1 PISDPSG11 ● ● UBE2L6 ● PLAT ● ● ARF4 BLZF1 HLA−E ● MAGEC1 ● ATP6V1G1 S100P ● OAS2 ● ● MMP15 ● ● ● ITGA2 ● ● ●SOD2● LGALS9 PSG1 ●SP110 ● IFIT1 ● ATOX1 IL23A OAS1 TACSTD2 PTGS2 ● PANX1 LCN2 ● ● ● ● ●DUSP5 ● CCSPOLD4 RRBP1 ●MX2 ● HYAL1 ● TFPI2 ● ● MXD4 ● ●●● ● ● ● ● GRN PLAUR ● GSN DUSP1 P4HA2 ● ● ● ATP1B1 TNFAIP2CD9 ● PSAP ● ●● ● ● ISG20 ●

S100P ATP1B1 RRBP1 IGFBP3 PISD ● COL1A1 ● ●IL23A● PSG1 TACSTD2 ● PSG11 HYAL1● ● PLAT ● ● ● CCL20 SLPI MMP15 ●MAGEC1 SDC4 ITGA2 SPINT1 PON2 ● MFI2 SLC6A8 TNFAIP2 ● ● ●● RARRES1 ● ● QPRT ● ● ● DUSP6 WFDC2 TFPI2 ● ● PANX1 MYRIP ● ●IGF2 ●IL1B ● LGMN HIST1H2AC ● PRSS8 LCN2 BCL11A UBE2H ● ●● ● BECN1 HIST1H2BK ● MAP2K3 PTGS2 ● ● ● ● ● ● ● DUSP5 MFGE8 ● CD9 AREG ● GSN DNAJB2 POLD4 SOD2 PSAP RAB9A ●ARF4 ● ATP6V1G1 ● ● BIRC3 ● ISG20 ● ● ● ● ● BLZF1 TXNIP ● ● SP110 ● GADD45A ● LY6E ● TNFAIP3 ● IFNGR1 CCS PSEN1 UBE2L6 TIMP1 ● IFIT1 RNF103ATF3 ● STAT1● LGALS9 ●● ● ● ● ● ● ● OAS2MAP1LC3B ● GRNDUSP1 ● CDKN1A TAP1 MX2 USP9X OAS1 ● ● KIAA0247 ●● HLA−EMXD4 ● ●● ● PLAUR ●ATOX1 P4HA2● BST2 ● SERPINE1 ● ● ● ● CTSB ● NEU1 ●

●

● ●

Pathway: DUNNE_TARGETS_OF_AML1_MTG8_FUSION_UP There are 37 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): S100A8 Weight Factor: 1.398 Major Gene (NEG): IL6R Weight Factor: 0.956

NEG ALL Major Gene (NEG): IL6R Weight Factor: 1.406 Major Gene (BCR/ABL): S100A8 Weight Factor: 0.675



FNBP1 ALDH3B1 ● GCA CD24 ● ●

BPI AZU1

● ●

PRG2 CTSG RASGRP2 ● RNASE3 MS4A3 ● ● GCA ● ● S100A8 LST1 ATP2B4 SELPLG ● ● RNASE2 ● ● IL6R ● ● LAPTM5 PTGER4 ● HSPA6 CXCR4 IGFBP7 BTG1 ● ● ● ●● ● OS9 CD302 NUCB2 NFE2 ● LCP1 ● MYO1F ● ● ICAM3 CAT ● SLA

CTSG

●

●

● FNBP1

●

●

CSF3R CD24 PSTPIP1● ● CST7 ALDH3B1 ●

●

●

NKG7 ALOX5AP

● ●

●

●

AZU1 PRG2 ●

SLA

●

●

NFE2

●

RNASE3 BTG1

● ●CXCR4

IL6R

ALOX5AP CSF3R

●

●

ATP2B4 LCP1● IGFBP7

● OS9 ● ● RNASE2 NUCB2 ● LST1 CD302RASGRP2 MS4A3 ● ● PTGER4 ● ● ● HSPA6 ● ICAM3 ● PSTPIP1● ● SELPLG NKG7 ● BPI ● MYO1F ● S100A8 ● LAPTM5 ● ● ● CST7 ● ●

CAT

●

Pathway: TOMIDA_METASTASIS_UP There are 17 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): DAD1 Weight Factor: 1.375 Major Gene (NEG): TUBA3D Weight Factor: 1.255

NEG ALL Major Gene (NEG): TUBA3D Weight Factor: 1.327 Major Gene (BCR/ABL): DAD1 Weight Factor: 1.242



GNAI2

TUBB

●

●

PSMD2 SNRPF

●

● TUBA3D DAD1

● CXCL1

GNAS

●

●

● ●

●

PTTG1

CKAP4

●

●

GNAI2

●

METAP2

●

CXCL1

●

●

TUBA3D PSMD2 ●

TMSB4X IER3

●

●

●

METAP2

GNAS

SNRPF

ALG3

ECH1

●

PTTG1

●

●

●

●

CPLX2

●

CPLX2

TUBB

TFAP2A

ALG3

●

IER3

●

●

TFAP2A

CKAP4

DAD1

●

● ECH1

●

● TMSB4X

●

Pathway: HU_ANGIOGENESIS_DN There are 30 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SOD1 Weight Factor: 1.408 Major Gene (NEG): MDH1 Weight Factor: 1.201

NEG ALL Major Gene (NEG): MDH1 Weight Factor: 1.328 Major Gene (BCR/ABL): SOD1 Weight Factor: 1.234



PTP4A2

●

NDUFB6

DHX15 PLXNA2

●

●

● GTF2A2 SET ● ●

CKS2

●

●

●

MCM6

●

●

ATP5O

SMYD2

● SOD1 ●

PFN2HMGN4

●

GCDH

●

H2AFZ

●

●

MDH1

● POLR2K ●

GPI

●

DHX15 GCDH

GNAI1 CDK2AP1

●

●

●

PSMB1

HMGN1 RPA3

●

●

VAPA

●

●

DARS

●

GMPS

●

CKS2

●

GMPS

ATP6V1G1 ANXA7

●

NDUFB6ZNF217

GPI

●

●

VAPA

●

●

●

SMYD2 PFN2 MCM6● ● RPA3 ●

H2AFZ

●

GNAI1 PSMB1 ●

● PLXNA2

●

MDH1 ATP6V1G1 ANXA7 POLR2K ITM2A

●

●

●

●

●

● DARS GTF2A2

ATP5O ● SOD1 ● SET● CDK2AP1 HMGN1 ●

●

●

●

ZNF217

●

HMGN4

● PTP4A2

●

● ITM2A

Pathway: APPIERTO_RESPONSE_TO_FENRETINIDE_DN There are 32 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PGK1 Weight Factor: 1.403 Major Gene (NEG): MDH1 Weight Factor: 1.046

NEG ALL Major Gene (NEG): MDH1 Weight Factor: 1.452 Major Gene (BCR/ABL): PGK1 Weight Factor: 1.311



DHFR ATP5J2

●

●

●

NDUFC1

●

DHFR

PPP1CC

●

● BANF1 TMSB4X

●

PPIH IFITM2 HIST1H4C ● NDUFA2

● ● TRIM28ATP5O● ● ●

●

● ●

● ATP5B

●

SET

● IFITM3

PTMA

●

●

●

SET

PPP1CC●

●

●

H2AFZ

●

MDH2 EGFR ●

COL3A1 NDUFC1

● ATP5B

●

● IFITM3

● IARS2

●

MTX2 FLI1

●

● ●

●

IFITM2

●

●ARFGEF2 PGK1 MDH1

●

●

●

LDHA ● NDUFA2

●

● COL3A1

●

TMSB4X ATP5J2 FCGR1A ATP5O ●

●

LDHA EGFR

●

● MDH1

●

●

PTMA ● FCGR1A

●

● IARS2

PPIH

RSU1 HIST1H4C

●

BANF1

●

●

ASNS

SERPINB2

●

TRIM28

MTX2

PGK1 FMNL1 H2AFZ ●

RSU1

●

FLI1

●

●

ARFGEF2

MDH2

FMNL1 SERPINB2

ASNS

●

●

Pathway: LINDGREN_BLADDER_CANCER_CLUSTER_2B There are 295 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): JAK3 Weight Factor: 1.426 Major Gene (NEG): TIMP2 Weight Factor: 1.318

NEG ALL Major Gene (NEG): TIMP2 Weight Factor: 1.614 Major Gene (BCR/ABL): JAK3 Weight Factor: 1.335



HLA−DQB1 LAMA4 RND3 HLA−DPB1 DAB2 LUM ● BRPF1 HLA−DMA HLA−DRA ● ACTG2 BMP5 ● COL15A1 ●SELE ● EFEMP1 ● MYL9MT1G MT1H ● PITX2 POSTN RGS5 COL1A2 ● ●● ●● CYR61 ● KLF4 TGFBR1 PDZRN3 ● MOXD1 ETV1 ●● MT1E CCL15 ● ARPC2 GEM ● IL7R GNG11 IFITM2 CDC25B ● AOC3 PMP22 TNC ● DNAJC3 PRRX1 SLC7A2 VCAM1 ● ● AMOTL2 EFHD1 ●DHRS12 GRK5 MPP1 ●● KLRG1 GPR116 ●RBP1 DNAJB9 CLIC2 ● HLF ● ● ● ANGPTL2 ● ● MT1X ● ● ● ● FCGR2B CALM1 ●TCF25 ● NRP2 ●EDNRA RAC2 ●IL16 ●● ZAP70 RCAN2 THBS2 PHTF2 ● FILIP1L SSR1 ●●NUAK1 ●PCDH7 TBC1D8 ●●●●● ●ELN ● ● SPAG7 CCL13 IGFBP7 KLRK1 IGLL1 SERPINF1 YWHAZ ● JUN SERPING1 ● ● ● MSN ● MT2A C3AR1 ● HMGCS1 SYNPO PDE1A ● DNAJB5 ● ● ● PDGFRB FOXF1 ● ● ● TTN LCK ● TSC22D3 SYN3 EMP3 ● COL16A1 TRAF1 ●MGP LCP1 IL2RG RALB MCAM ● ● PALLD ● ● GJA5 ● IL32 ● ● PCOLCE ●●● PCP4 ● CTSG PROS1 SRPX NFATC1 ●●●CNN3 ● CD97 ● ●●EGR1 ●EDIL3 ● ●● PTRF CXCL12 ADAM19 ● ● CLIC4 ●CYBB ● ●BMP2K ●●RGS10 ●●DDR2 ITGA4 SDC3 ● JAK3 ●GADD45B PDGFRL ALOX5AP ● ●ITGAL LRIG1 ●●● ● SERPINA3 CST7 ● ● ENTPD1 MMP2 COL6A2 ● PECAM1 CCL2 IQGAP2 ● ADORA2A COL6A3 DPYSL2 MYO1F ● ● ● FHL1 MALT1 ● COL5A2 ● GSN ● ITM2A ATP1A2 ● ● ●IFITM1 EVI2A ● ZFAND5 ●● RNASE6 ● PNOC NFIL3● DAAM2 NFKBIA ● ●COL6A1 ●● AURKB ● EPB41L2 ●SVEP1 RGS11 ●● PIM2 MFNG CTGF CHSY1 ● ● ● ● ● ● SOCS2 TES ● ● ● ● ST6GAL1 ● ●S100A7 DKK3 ● YKT6 NR2F1 ● TIMP2 MPP3 ●● RAMP3 RARRES2 PIK3CD ICAM1 ● ●● ●PAPPA ●HLA−DRB6 PPP1R12B ● ●IL10RA ●TCF7 AQP1 ● TNFAIP3 UBE2J1 GUCY1A3 IL27RA NOV TOX ●SELL CDC42EP3 ● ● SREBF1 ● LGALS1 FBLN2 ARL4C ●FYN NNMT ●● ● ● ● CSRP1 FOLR2 RGS2 ● ●● ● SOCS3 CH25H LEF1 ● ● SPRY1 ● MYO5A ● ● ● ● ●● SIRPA SRGN ● CELF2 ●SON ● PDPN MICAL2 ●BIRC3 EVI2B SH2B3 ● ●● LCP2 CLEC10A ●● ● IFITM3 ● NUMA1 ●NR4A1 ● ●APLNR ● RUNX2 PODXL AIF1 ● CRTAM PTK2MYLK IER2 ● TACC1 ●● ACTA2 AP1S2 LGALS2 ●● ● ● TPM1 ●RGL1 IFI30 ● COL18A1 ● DUSP5 ITK ● PLAUR KRR1 ● PTPN7 ALDH2 STOM ● DOCK2 ● NFKBIE ●● ●JAM3 ● ● PRKAR1A ● PPP1R16B ●● MAPK7 BCL2A1 ●● ●DDX3Y LAPTM5 SPARC PDGFRA SLC16A2 ●● ●●RUNX3 ●IL1A ● ●●●●ANXA6 TMEM158 ●C1R ●● ●●THBD HLA−E AFF1 ●HHEX MAP1A ● ISG20 ● TCF4 CD302 ● ●CXCR4 ●PXDN ●RNF41 C1S ● ● ● ● ECM2 ● ● ●●●AEBP1 FGL2 ●● ●● ●DHODH NID2 ●●PRKCH ●●RHOH ●● ●● ● KIAA0922 CRIP1 GLIPR1 ● ●●TPM2 SAMHD1 ● GPM6B ● CAV1 AKAP12 ● ● ● TPST1 ANPEP ● ● ●● MAF ● ●●LAMB2 ● ●● CD52 ● LIG4 ● ● FYB

●

● ● ●●

NUAK1 PRRX1 GPR116 SLC7A2 PDZRN3 ●●COL1A2 PAPPA VCAM1 PTRF NID2 MICAL2 CCL15 ●●EFHD1 ●● ELNHLA−DRAGPM6B NOV ANGPTL2 PCOLCE ACTA2PCP4 ● ● ● ● HLA−DQB1 RUNX2 AOC3 CLIC2 ● TOX ●RND3 TMEM158 SERPINF1 AQP1 ● TPM1 FCGR2B ● ● ● CXCL12 ● DDX3Y ●●●SYN3 HLA−DPB1 ICAM1 AMOTL2 FILIP1L HLA−DMA CD302 GUCY1A3 ALDH2 RCAN2 ●●KLRG1 DHRS12 ● ● ● MAF S100A7 ● CDC25B CRTAM ● ● ● RNASE6 ● ● ● ● ● FGL2 HLF ● SYNPO CNN3 POSTN LUM ● ● CYBB ● ●●● ● ● IQGAP2 ● ● CH25H PHTF2 BMP5 ●C1R ● SREBF1 CLEC10A COL15A1 LAMA4 ● ADORA2A CCL13 NNMT ● ●●ST6GAL1 ● ●STOM SLC16A2 ● PALLD ● RGS5 ●RAMP3 ●PDGFRB ● EFEMP1 CAV1 ZAP70 PROS1 PITX2 HLA−DRB6 ● ● CHSY1 ● ● AIF1 CDC42EP3 IFI30 MALT1 ● THBS2 GEM ● TNC ●● ●MMP2 SELE ●PCDH7 ● CD52 TPM2 FOLR2 DNAJB9 ECM2 ●PRKAR1A ● ● SELL ETV1 ●MPP3 ● MGP ●MYO1F ●●● ● C1S SAMHD1 PLAUR ● ZFAND5 ● CELF2 ADAM19 ● PRKCH ● ● GLIPR1 ● ● RALB ● ● SVEP1 ● HMGCS1 TGFBR1 SPAG7 RBP1 RGS2 ● ● NFATC1 ● ● ● ● ● ● GADD45B BCL2A1 ● ●CCL2 ●PDE1A ● TES IFITM3 EGR1DOCK2 ●ISG20 CRIP1 ALOX5AP KIAA0922 NFKBIE ●PECAM1 LRIG1 ●● ●TCF4 IL27RA ●● DNAJB5 ●●SPARC SH2B3 ● ●● ● RGL1 AEBP1 ●SDC3 ● LCP1 CLIC4● NFKBIA ●LCP2 FYN IFITM1 ● SPRY1 ● PDGFRL TNFAIP3 ITGA4 IGFBP7 ● PNOC MT1G KLF4 JAM3 ● CTGF NR4A1 ● ● MYO5A ● ● ● ● ● ● IFITM2 CTSG ● ● ●DUSP5 PPP1R12B ● ●NUMA1 ● ●COL5A2 ● UBE2J1 ● ●FHL1 ● ●● C3AR1 DHODH EDIL3 ● PDPN ●● ●● ●CALM1 RARRES2 HLA−E ● DPYSL2 ● ● PIM2 FOXF1 TACC1 ● ●● SOCS2 RGS11 ● ●●DAB2 THBD TSC22D3 ●JUN MAP1A COL18A1 LEF1 ● IER2 SRPX ● ARL4C MT2A● ● ● ● ● FBLN2 EVI2B MOXD1 BRPF1 ATP1A2 ● EPB41L2 ●PODXL MT1H ● ● ● ● ●● ● LGALS2 JAK3 ●●●● ● RUNX3 GSN ● RNF41 SIRPA ● ●● ● MT1X ● NR2F1 KRR1 ● ● COL6A1 MT1E ●BIRC3 ● AKAP12 ●CST7 COL16A1 ●YWHAZ IGLL1 SERPINA3 ●DDR2 ●TIMP2 EVI2A LAPTM5 HHEX CYR61 IL16 SERPING1 ●MAPK7 ● ●●KLRK1 ●EMP3 SON ●TCF25 ● ● ● ARPC2 ● AURKB ● ● RAC2 CD97 ITGAL ● AP1S2 ● TRAF1 ● ● ●SOCS3 ● GJA5 CXCR4 TCF7 ITM2A PMP22 ● ●EDNRA ● ●● ● ● TPST1 ●● IL10RA ● GNG11 TBC1D8 ● MPP1 ● ●ANPEP ● COL6A2 ● PXDN ● ●●●●●RGS10 ●LGALS1 ● ● ITK ●● BMP2K MYL9 ●MYLK MSN SRGN ●●●NRP2 DKK3 ● ●COL6A3 IL2RG CSRP1 ●● MCAM ● ● PIK3CD ● PPP1R16B LIG4 ● AFF1 ● IL1A ● ● NFIL3 ● DAAM2 MFNG ● ● ●SSR1 PDGFRA PTPN7 ●APLNR ● TTNGRK5 LAMB2 ●●●YKT6 RHOH ●● ●●● DNAJC3 PTK2IL32 ● ●●●●● ● ● ● ● ● ● ● ●● ●●ACTG2●LCK ANXA6 IL7R ● ● ● ● ENTPD1 ● FYB ● ●●

●●

Pathway: EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_DN There are 36 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ADRA2A Weight Factor: 1.269 Major Gene (NEG): ADRA2A Weight Factor: 1.269

NEG ALL Major Gene (NEG): ADRA2A Weight Factor: 1.497 Major Gene (BCR/ABL): ADRA2A Weight Factor: 1.497



ARHGAP25

● BMP5

NELL1

● ● ● ARHGAP26FGFR2 VWA5A CNR1 TSPAN3 ● ● ● ● GTF3C1 JAKMIP2 TFAP2B ● PDZRN3 ● ● ● ● MTUS2 ●

SGMS1

● DISC1 ● IL4R ● ●

NELL1 TSPAN3 ● TFAP2B MTUS2 ● PDZRN3VWA5A LPAR2

PKP1 ● NRCAM RQCD1

MYCNPOU4F1

●

●

ABAT ADAM19 GOLGA2● CDH3 ADRA2A ● ● CELA2A ● POLG2 UBXN4 ●

●

●

ARHGAP26

ZNF330 ● PKP1

●

● MYO1E

●

DZIP3 ● ZFYVE16

●

●

ZNF330

●

ASTN2

●

●

JAKMIP2 DISC1

●

●

IL4R

●

●

FGFR2

●RQCD1 MYCN ● ● ●

CDH3

FOXF1

● ABAT

●

DZIP3

●

● ADRA2A ZFYVE16 GOLGA2

● ● ●CELA2A SGMS1 NRCAM UBXN4 ● POLG2 ● ● ● CNR1 ●ARHGAP25 ADAM19 ● ● GTF3C1 ● ●

ASTN2

●

●

BMP5

POU4F1 ●

● ●

MYO1E

LPAR2 ● FOXF1

● ●

Pathway: MATTIOLI_MGUS_VS_PCL There are 88 genes in this pathway. This pathway was detected by GSCA





HN1L SMARCA4 LAPTM4B ● CSTF2T CPNE3 PPAP2B XPO1 IGHG1 PPP1R15AFADD ● CSNK2A1 ● ● AP3D1 ● PRTN3 ●FAM20B ● ● RNASE3 NUP210 ● OPHN1 ICT1 ● TUBA1B LBR ● ● JUNB ELANE ● ● ● ABCE1 AKAP1 ●TPT1 SH3GL3 ● ● JUND ● ●CCT4PARP1 ● LILRB1 ● ● RUVBL1 ●WDR18 ● ● ● RPS6 IL8 S100A8 KIF21B ●WHSC1 ● EEF1A1 EPAS1 CAD ● CD74 ● PAICS ● ●SLAMF1 ● ● LST1 ● ● SEPHS1 MCM2 ● ● GADD45B ●ACTR3 PRDX3 ● RRP9 NUP62 ● ● ● ● HNRNPF MCM6 RBM10 PPBPLPCAT4 ● ● ● ● EXOSC2 ● SAC3D1 RPLP1 ● MCM4 ● CKS1B ASF1A MSH6 UBA1 ●CORO1A ● ● SMC1A PCNA SAP30 ● G3BP1 PSMC4 ● ● ● ●● ● ● ● ● MCM5 NASP●PSMD4 ● SNRPD3 CCT3 ● ● ● ● MAP4K1 RAN ● ● SNRPF TBCB ● PSMA3 ● TUBB ● B2M ● ESYT1 ITPA● PFN1 ● ● ● ENO1 ● ● ● SSR4 IGHM ●

●

●

●

LAPTM4BHN1L RPLP1 ACTR3 TPT1 MSH6 ● RPS6 ● SAP30 RNASE3 ● ●CSNK2A1 ● SMC1A ● ● IGHG1 EEF1A1 ● ELANE GADD45B ● ● JUND PSMC4 ● EPAS1 ● ● IL8● UBA1 ● IGHM JUNB LBR ● ● PPP1R15A RRP9 B2M ● EXOSC2 SAC3D1 ● PRTN3 ● ● ● NUP62 RBM10 ● CAD ● ● ● TBCB AP3D1 ● ● CD74● ● ● ●PPBP SH3GL3 ● ● FADD XPO1 ● MCM4PSMD4 CSTF2T PFN1LILRB1 ● ● ●HNRNPF S100A8 FAM20B ● LPCAT4ITPA WHSC1 ● ● ● ● ● CORO1A ASF1A ●● CCT4 CPNE3 TUBA1B ● ● ● ● OPHN1 ● ● ABCE1 ● ● ● MCM5 CCT3 PCNA G3BP1 PRDX3 ● NUP210 ● WDR18 ICT1 ● PAICS ESYT1 ● ● ●RUVBL1 MAP4K1 ● ● NASP SNRPD3 ● ● MCM6 KIF21B ● ● PARP1 ● ● ● ● PSMA3 RANCKS1B● ● SEPHS1 LST1 TUBB ● MCM2 ● ● SMARCA4 ENO1 ●PPAP2B ● SNRPF ●AKAP1● SSR4● ● ●SLAMF1 ● ●

●

●

●

Pathway: MATTIOLI_MULTIPLE_MYELOMA_WITH_14Q32_TRANSLOCATIONS There are 28 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CCND2 Weight Factor: 1.272 Major Gene (NEG): SORT1 Weight Factor: 0.963

NEG ALL Major Gene (NEG): SORT1 Weight Factor: 1.438 Major Gene (BCR/ABL): CCND2 Weight Factor: 0.846



CSDA

MAF

●

● CXCL12

CYBB CX3CR1

●

● CD99

●

● CXCL12 ●

●

KLF4

● GALNT10

●

SRC

NUAK1SORT1 NTRK2●

IL6R

NTRK2●

●

● ● ●

●

CSDA ● CX3CR1

●

●

PXDN

●

KLF4

DPYSL2

●

● CD99

ABLIM1

● ● SORT1 CCND1SRC ● ● ●

PXDN

ABLIM1

●

● ●

DPYSL2

● ●

●

●

GNAQ PYGB ● GUCY1A3 CCND2

●

ITGB7

MAL

GNAQ WHSC1

●

●

●

● CYBB

●

●

CCND2

PKP2

GUCY1A3

PYGBIL6R

MAF

●

●

●

●

TBC1D9

FGFR3

CCND1

GYPC

●

● TBC1D9

ITGB7

NUAK1

● WHSC1 ●

MALFGFR3

● GYPC

●

GALNT10

●

PKP2

●

●

Pathway: FARMER_BREAST_CANCER_CLUSTER_7 There are 16 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TMEM41B Weight Factor: 1.279 Major Gene (NEG): MSX2 Weight Factor: 1.161

NEG ALL Major Gene (NEG): MSX2 Weight Factor: 1.321 Major Gene (BCR/ABL): TMEM41B Weight Factor: 1.211



BLVRB

RND1

●

●

●

● GHR DHRS2

ALCAM

ALDH3B2

CDH1

●

●

●

●

●

IRX5

MSX2

●

● TMEM41B

CDH1

●

DHRS2 AR

●

●

● AR

●

SREBF1 BLVRB

●

FASN

●

●

●

GHR SREBF1

SLC35A3

●

KIAA0182 MSX2

●

IRX5

KIAA0182

●

●

SCD

ALDH3B2

●

●

ALCAM

RND1

●

SCD

●

SLC35A3

TMEM41B

●

● FASN

●

●

Pathway: LI_CISPLATIN_RESISTANCE_DN There are 23 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MMP10 Weight Factor: 1.353 Major Gene (NEG): TDO2 Weight Factor: 1.165

NEG ALL Major Gene (NEG): TDO2 Weight Factor: 1.396 Major Gene (BCR/ABL): MMP10 Weight Factor: 1.08



CFH

●

IDO1

●

AKR1C3

TDO2

●

PCDH7

●

●

JAG1

●

●

LAMA4

●

● SKAP1

●

EDNRB AMIGO2

●

●

AKR1C3

●

CHRDL1 TES

●

●

● IDO1

●

ADM

●

MMP10CFH

●

FOXG1

● ADM

●

AMIGO2

●

GPR126

● PSG11

●

PPIC

●

●

MARCKS

TDO2

● PCDH7

JAG1

MEST

PSG11

● ●

LAMA4

●

●

●

GPC3

●

SKAP1 MARCKS●

●

CHRDL1

●

●

●

GPC3

●

EDNRB

● SEMA6A

BAMBI ●

FOXG1

TES

● MEST

PPIC

● ●

GPR126

●

MMP10

SEMA6A

BAMBI

●

Pathway: XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP There are 33 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MACF1 Weight Factor: 1.422 Major Gene (NEG): PHLDA1 Weight Factor: 1.276

NEG ALL Major Gene (NEG): PHLDA1 Weight Factor: 1.534 Major Gene (BCR/ABL): MACF1 Weight Factor: 1.34



UPP1

● FYN

● ASNS

●

●

●

LTB ●

FHL1

ARG2

●

●

●

●

PHLDA1

●

●

CARS

●

●

SLC4A7

ITPKA PCK2

●

●

MAP4K2

●

ITPR3 AKAP12

●

ISG20

●

CD44

●

●

HMGA1

●

●

●

●

ECE1

●

CARS PHLDA1 GRK5 ● ITPKA

●

SLC4A7

● ERCC1 PPP1R1A MACF1 CCL20 ●

●

STC1

MMP1

●

●

●

HPCAL1

●

TIMP1 ISG20 HMOX1 ●

●

HMGA1

PCK2

●

CDK17

●

CD44 ASNS

●

● RIN2

UAP1

●

●

PPP1R1A GRK5 ● ECE1 ●

UPP1

●

●

PLAU ARG2

TIMP1

●

●

●

ERCC1

●

● ● KIAA0247

MMP1 HPCAL1 MACF1

CDK17 KIAA0247

STC1

●

●

● CCL20

ITPR3 MAP4K2 LTB ● ●

HMOX1

PLAU

● UAP1

●

●

●

RIN2

FYN

●

● AKAP12 FHL1

●

●

Pathway: DAUER_STAT3_TARGETS_DN There are 26 genes in this pathway. This pathway was detected by GSCA





STAT1 IFI35 ●

PDK4

● ●

●

HSPA1B

IFIH1 TLR3 ●

●

HPGD

● TRIM14 ● ●

●

IFI44

●

●

IFI35

●

PRPF4B PGRMC2

●

●

STAT1 IFIT1 ●

ID3

OAS2

●

IFIT3

●

OAS1

MX1ISG15●

●

●

●

●

● TNFSF10

●

PGRMC2 TRIM14

●

●

●

IFIT1 MX1 TNFSF10 IFI44 ● OAS1 ●

●

PDK4

IFI27 OASL

●

OAS2

ISG15

●

HPGDHSPA1B OASL

● ●

IFIT3

●

LAMP3

● ●

PRPF4B

●

HSPA6

●

GRB14

●

ST8SIA4

HSPA1A

●

IFI27 HSPA1A

●

● LAMP3

HSPA6

●

● GRB14 ST8SIA4 ID3 ● ● ● IFIH1 TLR3 ● ●

●

Pathway: WANG_METHYLATED_IN_BREAST_CANCER There are 31 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FOSL1 Weight Factor: 1.273 Major Gene (NEG): FOSL1 Weight Factor: 1.273

NEG ALL Major Gene (NEG): FOSL1 Weight Factor: 1.465 Major Gene (BCR/ABL): FOSL1 Weight Factor: 1.465



●

SLC3A2 GADD45A

●

CDC25A

●

●

●

ZYX

●

● DUSP1● FOSL1 MYO1B ● ● ● CLC

● PTRF ●

GJB3

●

STK17A

●

KRT17

●

IRS2

●

● ●

UPP1

●

TNFRSF10B MAFF SMURF2 ● THBS1 ●

● SLC7A5

EPHA2 CAV1

F3

●

●

●

CTNNA1

ETV5

●

INHBA SLC9A1 ●

●

TUBB

DKK1

●

TUBB

TNFRSF10B SLC9A1 THBS1 INHBA

PTPRG

SERPINB8

FYN

●

●

●

●

CDC25A

●

●

KRT17 FOSL1PTRF ● IRS2 ● ● DUSP1 CAV1FYN EPHA2 ● MYO1B ● ● SMURF2 ● ● GJB3 ● DKK1 ● ● CLC

●

●

●

ZYX ● SLC7A5

●

ETV5

CTNNA1

● STK17A

●

●

PTPRG

● MAFF GADD45A ●

●

SLC3A2SERPINB8

● F3

●

UPP1

●

●

Pathway: DIRMEIER_LMP1_RESPONSE_LATE_DN There are 25 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): RPL29 Weight Factor: 1.399 Major Gene (NEG): RPL29 Weight Factor: 1.399

NEG ALL Major Gene (NEG): RPL29 Weight Factor: 1.519 Major Gene (BCR/ABL): RPL29 Weight Factor: 1.519



UBC

PSAP

HLA−DMA

● TXNIP

● ARF5

●

MAP4K1

●

●

●

BTG1

● ●

RPS5 RPS19

●

●

TAF10 ISG15

●

●

● IFITM1

RPLP0

●

●

ASAH1

CD27

CHI3L2 ●

CHI3L2 IFITM1

●

WAS

ST5

●

●

●

●

GAPDH

●

●

HPCAL1

CD27

●

●

PSAP MAP4K1

●

●

RPS19

●

RPS5

● TAF10

ARF5

RPLP0

●

●

●

●

●

●

ARHGDIB

BTG1

●

RPL29 FAU

●

ISG15

RPL29

● HLA−DMA

GAPDH

● ARHGDIB

LSM2

●

●

HPCAL1

● RPS11

●

●

TXNIP

●

ASAH1 WAS

●

ST5

●

RPS11

LSM2

UBC

●

FAU ● ●

Pathway: RUGO_ENVIRONMENTAL_STRESS_RESPONSE_UP There are 27 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FGFR4 Weight Factor: 1.37 Major Gene (NEG): FGFR4 Weight Factor: 1.37

NEG ALL Major Gene (NEG): FGFR4 Weight Factor: 1.497 Major Gene (BCR/ABL): FGFR4 Weight Factor: 1.497



●

BNIP3L

●

● COL3A1

●

DAXX

RHOD

●

●

● EIF4E

●

●

IGFBP3

TPR

●

AP3B2

●

NDRG1

●

●

●

CTGF

●

HGF●

FGFR4 NGF

●

●

●

●

●

CXCL2 HLA−DQA1

GLRX SOD1

FN1

●

CXCL2

PRDX4 LCK

●

TPR

●

●

●

TAF1C

CALU

ANXA1

VIM ANXA1 ●

CTCF

RHOB

●

VIM

●

● HLA−DQA1

CTCF

NDRG1

●

● BNIP3L ● CTGF ● PRDX4 ● TAF1C GLRX ● ● NGF ● SOD1 ● COL3A1 FN1 FGFR4 ● EIF4E ● ● ● ● RHOD HGF

AKAP12

●

●

AKAP12

●

AP3B2

CALU

●

● ● RHOB

●

LCK

IGFBP3 ●

● DAXX

●

Pathway: WOOD_EBV_EBNA1_TARGETS_DN There are 41 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): WISP2 Weight Factor: 1.373 Major Gene (NEG): WISP2 Weight Factor: 1.373

NEG ALL Major Gene (NEG): WISP2 Weight Factor: 1.439 Major Gene (BCR/ABL): WISP2 Weight Factor: 1.439



EPB41L3 ACAA2

●

● KIF5B ● DYNLT3 PSMB8 IL13RA1 ● GPNMB● MFAP5 ● ● ABCC4 TGFBI ● KDELR2

SLC16A7 SPOCK1 ● ● ACTR2 ● GOLGA4 CLEC2B ● ● MAP7

●

ALCAM

IDI1

●

●

RGS2C4BPB S100P ● ● ABCE1 ● SLC39A6 IPO7 TAX1BP1 ● ● P2RY6 TSPAN8 PTGS2 ●● ● ALCAM ● ● INSL4 ● CALCOCO2 ● RAB13 MACF1 WISP2 ● ● MEST MYLK ● AKAP12

●●

●●

IQGAP1 GNAQ

●

●

●

UGP2

● TPM1

●

●

● MFAP5

●

●

RGS2

IL13RA1

●

DYNLT3

KIF5B

CLEC2B

●

●

●

EPB41L3 SLC39A6

MYLK ● IQGAP1

● TAX1BP1

●

●

WISP2

TGFBI ●C4BPB S100P IPO7 IDI1 ●CALCOCO2 ● ● ● MACF1 ● ● RAB13 ABCE1 ● P2RY6 INSL4 PTGS2 ● KDELR2 GOLGA4 ● ●TPM1 ● ● ● ● ABCC4 ● UGP2 AKAP12 GNAQ ● ● ● ● ● PSMB8 TSPAN8

●

●

ACTR2

SPOCK1MAP7 SLC16A7 MEST ● ●

● GPNMB ● ● ACAA2 ● ●

Pathway: GRUETZMANN_PANCREATIC_CANCER_UP There are 334 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MRPS12 Weight Factor: 1.441 Major Gene (NEG): XPO1 Weight Factor: 0.932

NEG ALL Major Gene (NEG): XPO1 Weight Factor: 1.533 Major Gene (BCR/ABL): MRPS12 Weight Factor: 1.13



FYN HLA−DRA RAP1GAP ATP1B3 ● PCOLCE TM9SF4 APOC1 PTGS1 ● SLPI SERPINE1 PPP3CA ●PDIA2 MYL9 TFF1 CLIC1 PDGFRB TRIP10 ●SDC1 CCNA2 ATF3 ● PSMC6 SRGN LGMN ARHGAP1 FBLN2 PLEC MMP11 ITGB4 ● ● ● ● MBOAT7 PDE1A LOXL2 ● HIST2H2BE ● IQGAP1 PLAT ● ATP6AP1 SEC23A SHFM1 ● ACVR1 ● ● YWHAH RALBP1 ● MYL12A ● GOLIM4● PLOD2 ● KLF5 ● ● TOP2A ● ●GGT5 ● ●RAB5B CTSK GADD45A LAD1 PMP22 ● ● ● PPP1R8 MKI67 KLF4 CASP4 SLC2A1 ●CD55 ARHGEF2 ● ● ● SLC1A3 COL1A1 HPGD GPC1 EXOSC7 ● CD53 ● PARP4 NDUFA9 ● HNRNPU ● ● PTPN9 MYLK ADSS ● ●CNN1 EVPL ●●● ALDOC ETFB ● CD47 LAMA4 ITGA2 ●TAP1 FLOT2 ●●● PLCG2 POLB SEPT8 ● ● ● GRB2 STOM CRABP2 RHOA TSC22D1 ● ● FAP CYFIP1 ● ● ● TIMP3 ● WNK1 ● ● TSN MPP3 ● ● CSK ● ● ● ● ● ● PSMA5 ● ●● ● KDSR ●KRT13 P4HA1 ● PUF60 ITGA3 ● AMPD3 ●● ● DLST ●OAS1 ● PRDX1 DYNLT3 LDHA ●TRIM29 ●● GBP1 STAT1 ●KYNU ● ● PPIG ● ● FLAD1 NBL1 PGK1 ● EPS8 IGFBP5 CETN2 ●GM2A ● ●THBS2 FABP5 ●MMP2 ● ● FN1 WNT5A HMGB2 MCM3 CD1C PYGB TNFAIP6 COL5A2 ● RAB2A ENO1 ● ● ● ASNA1 ● GBP2 ●RGS16 PXDN ● ● XPO1 ● NDUFB7 ● ● NMT1 MX2 ● CSTB CBR1● TFF3 ●● PFN1 MRPS12 WNT2 TBCB ● ● ● ARL6IP1 ● ABCG1 ● MGP ITGB1BP1 GLUD1 SOD1 ● ● BST2 ● ● ● ● ● ● ● ● ● ● CSNK1A1 COPS8 CBX3 CASP1 CLOCK CFLAR ● R3HDM1 SCNN1A ● IFI44L ● ●TANK SLBP ●TFCP2 ● INPP1 ● ●●●VDAC1 ●● SPINT2 TSPO SRI ● G3BP1 ●MAP4 ● ●● ●GK ITGB2 ●PRKDC ●ALOX5 PTPN12 SORL1 PSMB3 ITPR3 ● ●● ● ●PSMD14 KCNK1 ●● ZMYND8 C2LTBP1 CTSC ●●PYGL SULT1C2 FBN1 SFN ● ●S100P ●BIRC3 NSDHL PPP2R1A ● IL4R ● XRCC4 ● ● ● TUSC3 ● ● ENTPD1 CALD1 ADAM9 ● TUBB ● PRKACB GPI ● ●TXNRD1 ● ● ●●●●●PLN ● CYTH1 LCP1 MYH9 ● ●● ● DOCK2 PSME3 ●RALB YWHAZ ● ● RHOG ● ● ● ●EIF4G3 MYL6B ●● PAK2 TOP1 PSG11 RFC4 ●SHC1 ●NNMT POSTN AKAP12 LCP2 CKS2 DPYSL3 SNRPA ●NID1 APLP2 ●●IRS1 ● MYH10 ●CBFB ● ● MSN GEM PSMA3 BPTF ● TMSB10 ● ● IFITM2 ● ● ● ● MFSD10 ELF4 ● KIAA0247 ARHGDIA RCN1 TNFAIP3 SERPINH1 MCM6 ● ● SEPW1 ●CHMP1A ● ●HMGN4 SMAD3 PRNP PTPRC ● BST1 ●NCBP2 ●NDRG1 ●●● SPTA1 ● HCCS ●DHX8 ● ● GPX4 ● ● PIK3R4 LMO4 MPHOSPH6 ● ● ● ● ● ● ● ● ● CDK7 ● ● ITGB5 ● LAPTM5 ● IL1RN ● BZW1 PLAU PHB ADAM10 ● DPYD CELF2 ● DNAJA1 DYRK2 ● ● DGKA SUMO1 ●●● CD86 ●●● ● ●MMD ● ●EMP3 ● LAMP2 ●CENPF ● EMP2 PNP DNMT1 ● ●● ●DGKD MMP9 ● RIN1 DUSP5 ●●ARL4A ●●● ●●VCAN ● ●LUM GRN UGCG GDI1 ●DLAT DUSP6 ANXA5 ● ● ●USP14 ● ● SNRPB2 CCNG2 ● GNPDA1 STMN1 ● KIAA0101 ●●● UBE2C ANXA1 ● CRIP2 ● ECM1 ●● KIAA0196 CD9 ●PTGS2 CXCR4 ● ● ● ● ● ● ● ● EIF2AK2 S100A10 ● ● DHX9 ● PLAUR ● CKS1B ●● AREG ● GPX1 ● ●RAB31 LCN2 ● ● ● ● MELK ● ●CTSL1 ● SPARC NUP93 ● CAV1 ● ISG20 ● ●● ● SERPINA1 ● S100A11 ● ●●●●CSE1L IFI30 ● LAMA3 ●● ● FOXF1 CAV2 ● ● ● FYB ● ●

●

●

●

ENTPD1 ANXA1 S100A10 SERPINA1 ● ITGB2 P4HA1 TFF3 ATP6AP1 DYRK2 FOXF1 RGS16 ●PLAUR GPC1 ●FYB FN1 C2DUSP6 SLPI ●SPARC KLF5 TNFAIP3 S100A11 ITGB5 CNN1 NBL1 SULT1C2 PDGFRB ●●● STOM GNPDA1 ● CELF2 RAB31 TRIP10 INPP1 SRGN ● KRT13 ● ● AMPD3 ● ● RAP1GAP LOXL2 ● TSC22D1 ● ●PTPN12 YWHAH GADD45A ● SHC1 CTSL1 HCCS ALDOC DNAJA1 APOC1 ● ● CTSC FBLN2 NDUFA9 ● EPS8 ● PTPN9 COL5A2 ● ● HPGD ● CCNG2 ●● ●●● ● SDC1 ● ● FBN1 ● RCN1 ● SLC2A1 PTGS1 ARL4A ● PNP ● ● MMP2 ●● PSMC6 ● DOCK2 ● ●● ARHGAP1 ● ● NMT1 ●● SLBP ATP1B3 ● CD1C ● ● RIN1 DYNLT3 MMP9 ●LCN2 MMP11 GGT5 PDE1A TIMP3 ●LAMP2 ● NNMT PYGB ●● ● ●ITGA3 ●ATF3 ●● ● MYL9 GM2A ECM1 ● SHFM1 ●● VCAN TXNRD1 NUP93 ARL6IP1 CBX3 ● COPS8 DLST MYL12A ● ● CD9 PLN LMO4 PPP1R8 MPP3 ● RHOA ● PRNP ● RAB5B CSNK1A1 ● ● ● ● ● ● SNRPB2 TRIM29 ABCG1 ● ● ● ● ● ● ● ● PSMA3 POLB ● FYN LCP1 ITGB1BP1 ● ● TFF1 DHX9 HMGN4 BZW1 ● CBR1 ● EXOSC7 MYLK ● PLEC CD86 ●● ● PSMA5 ●SORL1 ● ●● TFCP2 SEC23A ●R3HDM1 ●● ● TANK ITGB4 ● RALB CASP4 TSN CASP1 ADAM9 COL1A1 ● ● PFN1 ● PYGL LGMN NSDHL ●CDK7 HMGB2 PDIA2 ● ● ● ● ZMYND8 KIAA0247 SCNN1A ● ● PGK1 ● ● LAD1 DGKD ● LCP2 ● EVPL FABP5 ● ● ● ● KIAA0196 S100P ● SRI NDRG1 ●● CSE1L KCNK1 MYH9 ● XPO1 BPTF ●XRCC4 ●● ●● ●SUMO1 ●CSTB DHX8 ● ● ARHGEF2 ● CYTH1 GPX1 HNRNPU ● CD55 ●SMAD3 PIK3R4 ● ● GK USP14 PPIG ● HIST2H2BE RAB2A KDSR ● ●● ●●PLAT DLAT PSMD14 ●GRN PHB ●IQGAP1 ●● PCOLCE IGFBP5 ●● ● ● ● ● ●●TM9SF4 ● PTPRC ● ● ● ● ● CBFB ● SPTA1 ● SEPW1 ● GOLIM4 BIRC3 ●● ●● CXCR4 PARP4 AKAP12 ●●●EIF4G3 ● ● MGP ● DNMT1 CD53 DPYD ● ● SOD1 ●MELK CFLAR RALBP1 ●●WNT2 ● NDUFB7 ●● PMP22 ● ●LTBP1 DGKA IL1RN TBCB ADSS HLA−DRA ACVR1 ●CAV2 DUSP5 CRABP2 ●MMD ● RFC4 SFN ● ● ● ● PPP3CA ● ● ● MYH10 ● ● LAMA3 ● ● LAPTM5 ●CRIP2 ●● ●LUM THBS2 ●ARHGDIA GEM ● UGCG ● ●●CYFIP1 ●APLP2 ●● KLF4 STMN1 TMSB10 ● PSG11 PSME3 ● ● KIAA0101 LDHA ●MRPS12 TUBB ● ● ● MCM6 FLAD1 ASNA1 CENPF PLAU EMP2 ITPR3 CALD1 LAMA4 MPHOSPH6 FAP ●●● ● ●IFI30 EMP3 PXDN ● ELF4 PRKACB IL4R PPP2R1A WNT5A ● RHOG TOP1 PLCG2 ●CHMP1A ● ● MFSD10 ● ● IFITM2 ● ● PTGS2 ● YWHAZ AREG ● ●●●●SEPT8 ● ● ● NID1 ● ● ● ● ● ● TNFAIP6 ● ● MSN ● ● FLOT2 ●PSMB3 ● ●●●TOP2A ● BST1 ● PLOD2 GDI1 ADAM10 ● ● CSK G3BP1 ●● CLIC1 ● GPI CETN2 ● CAV1 ENO1 ● MAP4 ● ● ● PUF60 ● CKS1B BST2 ITGA2 UBE2C CLOCK ●● TSPO GPX4 ETFB MBOAT7 IRS1 ● ● ● MYL6B ● ●KYNU POSTN CD47 ● MCM3 ●PRDX1 ●●MKI67 ● ● ●● ● GRB2 STAT1 ●● CCNA2 GLUD1 DPYSL3 NCBP2 ● ● PRKDC ● ● SLC1A3 ● SNRPA ● ● ● SPINT2 ● ● ANXA5 ● WNK1 ● ISG20 ● ●SERPINH1 VDAC1 GBP2 ● ● ● ALOX5 CKS2 CTSK ● TUSC3 ● ● ● MX2 ● ● IFI44L ● ●● ● ● TAP1 ● ● ●SERPINE1 ●● ● ● ● ●OAS1 ● ● PAK2 EIF2AK2 GBP1

●● ● ● ●

● ●

Pathway: WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN There are 17 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): DUSP2 Weight Factor: 1.317 Major Gene (NEG): ATF3 Weight Factor: 1.035

NEG ALL Major Gene (NEG): ATF3 Weight Factor: 1.358 Major Gene (BCR/ABL): DUSP2 Weight Factor: 1.129



CYR61

●

CXCL9

●

● DUSP5

● CAV1

●

●

DUSP1

RGS2 DUSP5 ● DUSP2 ● ●

RGS2

●

IGLL1

●

● ●

KLRK1

●

●

IL1RL1

●

●

ZNF185

●

●

●

CXCL9

●

ATF3

●

DFFA C7

PPP1R7

●

HMGB3 DUSP2

HMGB3

●

IGLL1

●

●

PPP1R7 ZNF185

●

CYR61

JUNB

● ATF3

KLRK1

DFFA CAV1 DUSP1

●

●

IL1RL1

●

● JUNB

●

C7

●

Pathway: OHM_METHYLATED_IN_ADULT_CANCERS There are 21 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TIMP3 Weight Factor: 1.438 Major Gene (NEG): GATA4 Weight Factor: 1.326

NEG ALL Major Gene (NEG): GATA4 Weight Factor: 1.433 Major Gene (BCR/ABL): TIMP3 Weight Factor: 1.211



RASSF1 CCND1

●

CDKN2A

BRCA1

● ESR1

SOCS1

●

●

●

SFRP4 CDH1

●

●

●

●

● MLH1

● FHIT

●

●

SFRP1

CCND1SFRP4

●

CDKN2A APC

● RASSF1

● MGMT

●

● GSTP1

●

FHIT

●

●

●

●

●

●

BRCA1

RBP1 RARB

CDH1

●

GATA4

● ●

SOCS1

●

THBS1

TIMP3●

CDKN2B

●

HIC1

TIMP3

●

GSTP1

SFRP1

RBP1

●

CDKN2B

HIC1

MGMT

●

APC

GATA4

●

●

RARB

MLH1

●

●

●

●

THBS1

●

ESR1

●

Pathway: ALCALA_APOPTOSIS There are 70 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): RAC2 Weight Factor: 1.449 Major Gene (NEG): MARK2 Weight Factor: 1.191

NEG ALL Major Gene (NEG): MARK2 Weight Factor: 1.53 Major Gene (BCR/ABL): RAC2 Weight Factor: 1.148



RHOA SLC25A6 CASP1 TOMM20 OXA1L ● GNAS HLA−A ● ● ● ● ● RPLP0 ANXA7 GAPDH ● PFKP SLC25A3 CHMP7 ATP5B ● ● ATP5L ● RPL10A ● COX4I1 ● ● ● CD74 CASP4 MARK2 ● EIF3F ● ● ARL6IP5 ATP1A1 AURKA ● CYTH2 ● MATK ● ● ● ● ● QPRT● UBXN4 EEF1A1 ● CD7 BAX ● RHOH RIT1 ● DDHD2 HSPA8 GPI ● ● ● ● SDHC TIMM17A ● NUP205 ● ● ● BCAT2 TRAF3IP3 STX4 VDAC1 ● ● ● SYMPK MFAP1 IL32 ● ● XPO1 BNIP3L ● CCT5 CYFIP2 ●RAC2 ● ● ● MSH2 ● HCCS ● ● ● TMEM106C CEBPZ FAS MX1 ● FUSFES● ● GZMB ● HMGN1 ● PSTPIP1 ● ● SCCPDH ● ●RALB METAP1 ● CD48 ● ● ● ● TALDO1 ● SCAMP3

●

●

● NINLHADHA ●

●

PFKP FASMX1

●

RHOARPLP0 HMGN1 ● ● CEBPZOXA1L ●● ● ● ANXA7ARL6IP5 QPRT ● GNAS TALDO1 RHOHUBXN4 ● SLC25A3 CHMP7 ● RALB ● ● ● TOMM20 NUP205 CASP1 ● ● RAC2 ● ● ● ● ● ● CD74 FES ● SCCPDH MARK2 METAP1 GAPDH CYFIP2 TMEM106C● ● DDHD2 XPO1 ● ● ● TRAF3IP3● ● HSPA8 CCT5 HLA−A ● ● ● BAX SCAMP3 GPIVDAC1SYMPK ● COX4I1CASP4 ● ● ● ●● ● MSH2 MFAP1 ATP5L ● MATK ● ●RIT1 ● CYTH2 CD7 SDHC ● ● EEF1A1 ●● ● ATP5B HADHA ● RPL10A ●PSTPIP1 ● ● FUS●SLC25A6 CD48 BCAT2 ● ● ● STX4 ● IL32 ● BNIP3L ● ● AURKA TIMM17A EIF3F ● ● ● ● GZMB ● ● ●ATP1A1HCCS NINL ● ● ●

Pathway: LIU_NASOPHARYNGEAL_CARCINOMA There are 49 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): BTF3 Weight Factor: 1.269 Major Gene (NEG): EIF1AX Weight Factor: 0.946

NEG ALL Major Gene (NEG): EIF1AX Weight Factor: 1.451 Major Gene (BCR/ABL): BTF3 Weight Factor: 0.888



INPP1 HSPD1 ZNF174 ● ●RAB8A CD4 ● EGFR CDC40 ● PIN4 SET SLC7A1 ● ● RNF10 ● ● SERBP1 PRKCI ● ● ● SSR1 ● CACNA1A ● UBE2L3 SELPLG EPOR ●MAPK1IP1L ● ● GM2A DNASE1L3 ● ● HLA−A ● CD59 ● ● PHF20 RAP2C WIPI2 B4GALT3 EIF1AX SEC16A ● ● PITPNA ● ● RAC2 ● ● ●● ● LGALS1 ● TAPBP JUP HMBS ● TGFBR3 ● ● EDNRB ARPC2● BTF3 ● SMARCD1 ADAM8 TAL1 ● ● ● RPL3 MAT2A FOXC1

●

●

● DDOST ● CD74

●

●

●

IPO9 DDX17

●

●

●

LGALS1

● PHF20

CD4 ZNF174● SEC16A

●

● HSPD1 ● SLC7A1 SMARCD1 IPO9 RAP2C PRKCI ● ● ● ● EDNRB EIF1AX GM2A ● ● DDX17 RAB8A SSR1 ● PITPNA SET ● ● ADAM8 ● ●INPP1WIPI2 SERBP1 ● ● ● MAPK1IP1L ● CD59 EGFR ● ● CACNA1A ● RAC2 TGFBR3 SELPLG ● ● ● B4GALT3 RNF10 ● TAL1 ● ● ● HLA−A CDC40 ● ● ● UBE2L3 ● HMBS ● CD74 TAPBP MAT2A ● DDOST RPL3 ● ● ● EPOR ● ARPC2 ●● JUP ● ●● DNASE1L3 BTF3 FOXC1 PIN4 ● ● ●

●

Pathway: LIAO_HAVE_SOX4_BINDING_SITES There are 23 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PFKFB4 Weight Factor: 1.327 Major Gene (NEG): PFKFB4 Weight Factor: 1.327

NEG ALL Major Gene (NEG): PFKFB4 Weight Factor: 1.454 Major Gene (BCR/ABL): PFKFB4 Weight Factor: 1.454



UBAP2L

GPRC5B

●

SMG5

PTPN14

● POU2AF1

●

●

NAV3

●

CTSC

●

●

MYEF2

SLC2A1

● NRP1

●

GNG4 ● PFKFB4

●

●

● ● LAMB1

● SERPINE2

●

●

VGLL4

●

SLC2A1 CTSC

● MAP4

NRP1POU2AF1 ●

●

NAV3

●

●

PAM AKR1B10●

UBAP2L

●

●

DKK1

● SMG5

●

CREB3L1

SEMA3C

●

●

●

SERPINE2 CREB3L1 PFKFB4

● VGLL4 ● ● RBM10 ● ● LAMB1

PAM

●

AKR1B10

● GNG4 MYEF2

● MAP4 ● RBM10 ●GPRC5B

HIC2

●

● SEMA3C

●

DKK1

PTPN14

● HIC2

●

Pathway: CAFFAREL_RESPONSE_TO_THC_24HR_5_UP There are 21 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PCNA Weight Factor: 1.443 Major Gene (NEG): IARS Weight Factor: 1.015

NEG ALL Major Gene (NEG): IARS Weight Factor: 1.364 Major Gene (BCR/ABL): PCNA Weight Factor: 1.242



SEPP1

●

TXNRD1

●

●

● PCNA

●

● RAB5A

GAL

●

●

PSMA2 ATP5G3

●

FNTA

●

SEPP1

LIG4

●

●

● TXNRD1

●

●

CCNA2 PCNA

IARS

●

IARS

EIF2A

● ZFP36L1 ●

RPS2

CKS2 ● ●

●

●

●

NCOA4

●

●

●

EIF2A

● ●

DDB1

RNF10

NCOA4

●

DDB1

●

TFRC

●

● NUCB2CKS2 ●

RPS2

●

ZFP36L1

TUBB

TFRC

●

●

PSMA2

ATP5G3 CCNA2

RNF10RAB5A

●

TUBB NUCB2

●

FNTA LIG4

●

● GAL

●

●

Pathway: BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN There are 36 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ADAM11 Weight Factor: 1.258 Major Gene (NEG): OMD Weight Factor: 1.191

NEG ALL Major Gene (NEG): OMD Weight Factor: 1.347 Major Gene (BCR/ABL): ADAM11 Weight Factor: 1.345



ALDH1A1 ABCA6 ● RPL34

●

●

TXNIP

●

TXNIP

●

PDK4 TNFRSF1B SPARCL1F2R●

●

●

DPT

● SEPP1

OMD

RBP4

PECAM1

●

NGFR ELN

●

●

●

PIK3CD

●

● CD34

●

●

●

IGF1 TNFRSF1B ● F2R

●

MARCH7 ● SFRP1

ADAM11● TGFBR2

ADIPOQ ERG

●

●

●

CAV1

●

CAV1 PECAM1 ●

MFAP4 FABP4

●

SPARCL1 OMD

ADCY2 NGFR ABCA6 ● ● ● POU2F2 ● ● TF ELN ● SEPP1 ●

●

●

MMP3

●

PDK4

●●

●

FOXN3 VWF●

● RPL34 DPT ALDH1L1

ALDH1A1

●

ADAM11 VWF ● ● ● ● ● ● TGFBR2 FOXN3 RBP4● ADIPOQ IGF1 ● MARCH7 PIK3CD ● ALDH1L1 ● ● ● MMP3 ● ● SFRP1TEK POU2F2 ● FABP4 ● ● ● TF MFAP4 ADCY2 ● ● ERG ● ●

●

●

●

● RPL31

CD34

RPL31

●

TEK

●

Pathway: FRIDMAN_SENESCENCE_UP There are 75 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TP53 Weight Factor: 1.42 Major Gene (NEG): RAB5B Weight Factor: 1.221

NEG ALL Major Gene (NEG): RAB5B Weight Factor: 1.527 Major Gene (BCR/ABL): TP53 Weight Factor: 0.995



MMP1 CRYAB SMURF2● ● ● VIM IGFBP3 ● CDKN1A TNFAIP3● ● CDKN2D SMPD1GUK1 RAB13 ● ● ING1 ● F3THBS1 ●IFNG ●HTATIP2 ● ● TGFB1I1 ● ● ● ● ● FILIP1L CYP1B1 SERPINB2 CITED2 ● RAC1 OPTN TP53 SERPINE1 ● IGFBP5 ● RRAS ● ● RAB5B SOD1 ● MAP2K3 ● ● ● RGL2 ●● ● ● CTGF ● CDKN2A CDKN2B IGFBP2 NDN ● IGFBP6 TFAP2A ● ● ● CDKN1C ● ● RABGGTA CREG1 HPS5 NRG1 ISG15 ●IGFBP1 ● EIF2S2 ● CLTB ● TSPYL5 IRF7 ● ● ● ● ●● IRF5 CD44 ● STAT1 RHOB ● S100A11 ● NME2 RBL2 COL1A2 ● ALDH1A3 ● ● HBS1L ● ● IGFBP7 ● IFI16 ● ESM1 IGFBP4 ● GSN ● TES● ●● FN1 ● ● RAB31 ● CCND1 ● ● IGSF3 PEA15 ● TNFAIP2 SPARC ● MDM2 HSPA2 MAP1LC3B

●

●

●

●

●

IRF7

● ISG15 HSPA2 ● OPTN STAT1 F3 IFNG ● SERPINE1 ● ● RBL2 ● CREG1 IGFBP4 ● TNFAIP3 ● TP53 ● FILIP1L RAC1 TNFAIP2 SERPINB2 ● ● ● ● CD44 SMURF2 ● CITED2 ● ● RGL2 RRAS ● CYP1B1 ● RABGGTA CCND1 NDN ● NRG1 ● ● GSN● ●IFI16 IGFBP1 RHOB MAP1LC3B ● ● ● ● ● SOD1 IGFBP5 TFAP2A ● RAB5B CDKN2B NME2 ● HTATIP2 HBS1L ● TSPYL5 ● IGSF3 ● ● PEA15 ● ● ●TGFB1I1 CDKN2D ● HPS5 MDM2 IGFBP7 ● ● ALDH1A3 ● COL1A2 ● CLTB ● ● ● SPARC THBS1 ING1 ● CDKN1A● ● ● IGFBP6 CTGF ● RAB13 IGFBP3●CRYAB● IRF5● ● MAP2K3 ● ● ESM1 VIM ● ● ● EIF2S2 ● ● ● ● MMP1 RAB31 ● CDKN2A CDKN1C ● S100A11 ● ● ● ● FN1 GUK1 TES ● SMPD1 ● ● IGFBP2 ●

●

●

Pathway: SAKAI_TUMOR_INFILTRATING_MONOCYTES_DN There are 68 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PRDX1 Weight Factor: 1.354 Major Gene (NEG): HNRNPA2B1 Weight Factor: 1.138

NEG ALL Major Gene (NEG): HNRNPA2B1 Weight Factor: 1.45 Major Gene (BCR/ABL): PRDX1 Weight Factor: 1.13



●

STX5 PPP6C ● CD63 CDC27 TBP SEC63 TAF9● TBPL1 ● ● ● ● CDC42 ● LSM6 ● ● ●CDK7 ● DNAJA1 ● CDKN3 ● PRKAR1A EPB41 ● ●CCNC ● ● PCNA SUB1 KDR PPIBPSMB5 ● ● PRPF4B PTGES3 ● ● ● SNRPB2 ● ● ●PRDX3 RAN● CCT8 IFI6 WRN PRDX1 ●HSPA5 ● ● CD86 ● ● ● ● ● SNRPF PRDX2NCOA4 ● CD1D ● CCT4 PPIA ● FCGR1A ● ● MGST2 ● ● MED7 IFI30 KAT2A ●TXN COPS5MACF1 ● ●ARIH1PRDX6 ● CD163 ● ● NEK1 ● ● ● PSMA5 ● ● ●HNRNPA2B1 ●DCT ● HIST1H1T RBM8A XPO1 ● ● PPIC CPSF6 ● ● CLEC4M CDKL1 ●

●

● RAD51C CSTF2 TOP2A UBE2E3

●

PRDX2GEMIN4

TAF6L

GEMIN4 GTF2H3

●

● ●CCNG2 ●

● TOP2A● PSMB5 CDKN3 MGST2 CD86 ● STX5 IFI6 ● ● ● ● PCNA PTGES3 ● TXN CCT4 ● PRDX1 IFI30 ● PSMA5 ● ● MED7 ● PRDX3 LSM6 PRKAR1A ● ● COPS5 ● ● ●SNRPF CPSF6 CSTF2 PPIB ● RANNEK1● HSPA5 ● ● PRDX6 CD1D CDC42 ● ● RAD51C ● ● CCT8 ● NCOA4 ● CDC27 ● HNRNPA2B1XPO1 TBP● ● MACF1● ● ● ● ● ● ● CD63 HIST1H1T KAT2A ● PPIA ● SUB1 TAF6L TAF9 CD163 UBE2E3 ● ARIH1 ● KDR ● CLEC4M DCT ● ● ● ● ● ● ● ●RBM8A ● SNRPB2 CCNC PRPF4B TBPL1 ● ● SEC63 EPB41 ● ● FCGR1A DNAJA1 ● CDKL1 ● WRN ● ● ● CCNG2● CDK7 PPP6C ● ● PPIC GTF2H3 ● ● ●●

Pathway: MORI_LARGE_PRE_BII_LYMPHOCYTE_DN There are 41 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CD22 Weight Factor: 1.295 Major Gene (NEG): ADCY7 Weight Factor: 1.067

NEG ALL Major Gene (NEG): ADCY7 Weight Factor: 1.375 Major Gene (BCR/ABL): CD22 Weight Factor: 0.706



MS4A1

●

GPR65 CD40

●

●

ITGAV

●

IL4R

● CD83

CD22 MCL1 ● ● BIRC3 LPP LY86● IL10RA PTPRC

● ●

●

WIPF1

PIP4K2A PTPN6 ● CD79B SIPA1 ● IL2RG SCD

●

● ●●

●

TAPBP

ITGAV ● LTB IRF8

●

● ●

●

●

CAPN1

AIM1 RGS14 CTSS SAMHD1

● ● ●

●

● LCP1

CTSH ALDH2 RASA3 ● ●SEMA4DGGA2 GNS ●

●

●

●

ADCY7 ● HIP1R UBA7 ●MACF1 ● FAM65B ● ● CAPN1 ● ● DOCK2

●

CD40

ALDH2 GGA2 ●

● IRF8 GNS ● LPP SCD ● ● MACF1 ● ● SEMA4D LCP1 ● RASA3 ● ● ADCY7 PTPN6PIP4K2A● AIM1 ● ● ● ● DOCK2

IL2RG SIPA1

●

●

SAMHD1 CTSS HIP1R FAM65B TAPBP ● ● IL4R ● ● ● CD79B LTB● MS4A1 ● ● CD22 CTSH ● ● ● MCL1BIRC3 PTPRC ● RGS14 LY86 ● ● ● ● GPR65 IL10RA ● UBA7 ●

WIPF1

●

● CD83 ● ●

Pathway: MORI_MATURE_B_LYMPHOCYTE_UP There are 52 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NCF4 Weight Factor: 1.374 Major Gene (NEG): AIM1 Weight Factor: 0.9

NEG ALL Major Gene (NEG): AIM1 Weight Factor: 1.461 Major Gene (BCR/ABL): NCF4 Weight Factor: 1.105



PTPN6 SDF2 IL2RG MEF2C IRF8 CTSS ●RAP1GDS1 ● SH3BP2 ● LPP RGS14 ● ● ● ● ● ID3 LY86 IL10RB● ● MCL1 GPR65● CD40 ● NCF4

●

● ● ●PIP4K2AIL10RA POU6F1 ● ● CTSH ● SCD CD83ADRB2 MS4A1 RAB8A ● ● FAM102A ● ● ● ● ● YTHDC1 ETS1 MAP3K8 WDR43 LCP1 SAMHD1 ● IFNGR1 ● ● ● B4GALNT1 ● GGA2 FAM65BABCA1 ● PHTF2 ● ● RASA3 PTPRC ● ● ● ADD1 ●ZFP36L1 MACF1 ● ● AIM1 ● MAP2K1 ● ● SORL1SELL ● ADCY7 ● ● JAK2 MYCBP2 ● ● ● SLC4A7 ● ●

●

SORL1

●

SLC4A7 GGA2 ● MACF1 ZFP36L1 FAM102A LCP1 ● MYCBP2 ● SH3BP2 LPP

●

ID3●

●

●●

POU6F1 ● ABCA1 ADD1 PTPN6 ● ● ● AIM1 RASA3 ● FAM65B PIP4K2A ● ADCY7 B4GALNT1 ● ● ● CD40 MAP3K8 ● SELL ●NCF4 ● MEF2C IRF8 PHTF2 ● ● ● ● MAP2K1ETS1 ● ● ● IL2RG SCD YTHDC1 MS4A1JAK2 ● ● MCL1 ● ● WDR43 ● ● ● ● SAMHD1 IFNGR1 RGS14 CD83 ●IL10RB ● ● ● ● SDF2 ● PTPRCIL10RA

●

●

●

CTSH LY86 GPR65 RAP1GDS1 ● ● ● ADRB2 RAB8A ● CTSS ● ●

●

Pathway: COLLIS_PRKDC_SUBSTRATES There are 16 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IGHG1 Weight Factor: 1.298 Major Gene (NEG): SNRNP200 Weight Factor: 1.133

NEG ALL Major Gene (NEG): SNRNP200 Weight Factor: 1.356 Major Gene (BCR/ABL): IGHG1 Weight Factor: 1.215



ABL1

FOS

●

MYC

●

●

WRN

RPA1

● ●

●

● ●

● SP1

● WRN

C1D

●

POU2F1

●

CTDP1

●

POLR2A

IGHG1 HSP90AA1

●

●

●

SP1

●

MYC

●

● ABL1

PARP1

POLR2A

XRCC4

●

XRCC4

●

●

●

●

SRF

●

RPA1

●

IGHG1

●

SNRNP200 C1D

HSP90AA1 PARP1

●

POU2F1

●

SRF

SNRNP200

●

CTDP1

FOS

●

●

Pathway: DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER There are 61 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NUP153 Weight Factor: 1.536 Major Gene (NEG): NUP153 Weight Factor: 1.536

NEG ALL Major Gene (NEG): NUP153 Weight Factor: 1.426 Major Gene (BCR/ABL): NUP153 Weight Factor: 1.426



THOC1

GABPA

FBXW11

● CTTN ● ASH2LE2F3TAF2 H2AFY ● PRKCI ● ● TOMM70A THUMPD1 ● ● ● NIPBL KIAA0196 LSM1 PPP1R12A ● ● TXNL1● ATP11B ● ● ● KPNA4 AKAP9● RASA1 NUP153 ● NAPG ARMC8 TERF1 ● ● ● RAE1 RYK ● ● ● CEBPG ● KBTBD11 RB1CC1 ● ● ● FXR1 MFN1 GABPA ● MAP3K1ING1COG5 ● ● ● ● MTMR6 ● ● PIK3CA MIPEPPPFIA1 ● KRIT1 DCTD SDHC ● BRWD1 ANKRD46 IPO8 PPM1A ● ● ● PEPD SEC23IP ● ●● ● ● ● SIAH2VPS41 ● ● GATAD1 TPD52 ● PAK2 ● MRPS11 NDUFB5 ● ● NEK3 ● ● TBCA CDK8 PDCD6 ● ● ● ● ● GTF3A MAPK8 RFC4 ● ● ● ●

● BRWD1 PIK3CA

●

SEC23IP ●

●

TXNL1

● NIPBL FXR1 KBTBD11 PPM1A RYK ANKRD46FBXW11 RB1CC1 RAE1 ● ● TAF2 ● NUP153 ● ● PPFIA1 ● AKAP9 E2F3 ● THUMPD1 ● ● GTF3A ● MAP3K1 KIAA0196 ● TOMM70A ● PPP1R12A GATAD1 ● ● ING1 H2AFY ● THOC1 ● RFC4 SIAH2 ● RASA1 ● ● ●PRKCI ● ● ● ● ATP11B MTMR6 ● ● ARMC8LSM1 TBCA● SDHC TERF1 ● PDCD6 ● ● ASH2L● ● KRIT1 MAPK8 ● ● IPO8 ● COG5 ● NAPG ● NDUFB5 DCTD MFN1 ● ●MRPS11 ● ●CEBPG KPNA4PEPD ● ● NEK3 ● ● ● ● MIPEP ● ● ● PAK2 ● CTTN VPS41 ● ●

TPD52CDK8 ●

●

●

Pathway: ROSS_ACUTE_MYELOID_LEUKEMIA_CBF There are 59 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HYAL2 Weight Factor: 1.316 Major Gene (NEG): ITGB4 Weight Factor: 1.291

NEG ALL Major Gene (NEG): ITGB4 Weight Factor: 1.419 Major Gene (BCR/ABL): HYAL2 Weight Factor: 1.366



MN1 TRH ●HIF1ADUSP2 ● BLVRA TRIO ● IL15RA ● PMAIP1 PSD3 DEXI ● ADARB1 ● CD52 ● ● ● ●JUNBPURA VAMP5 ● MKNK2 ● OGG1CLIP2 SIPA1L1 ● ● ● BAIAP3 ● ● MYH11 ● ● ATP2B4 PTGIR RHOB ITGB4 ● ● KDM4B SYNGR1 CRIP2 ● CIITA ● DISC1 ● CCND3 ● ADCY7 ● CD34 ● ● PRAME ● HYAL2● ● ● ● RUNX1T1 SLC25A1 CACNA2D2 ●HPGDS ●CD58 ISG20 HLA−DPB1 ● SPARC ● ● DUSP6 ● PTGER2 ROBO1 ● ● CBFB HLA−DPA1 ● ● HLA−DMB ● HOMER2 ● ● IL5RA ● ● ABR CAV1MAN1A1 ● ● TBXA2R ● ● NCALD ● WIPF1● ● POU4F1 ●

● PGM1 ●

●

TRIODISC1 DUSP2 ADCY7 PURA ● ● MKNK2 TBXA2R ● ●● MAN1A1 PMAIP1 ●CIITA ● RHOB DUSP6 ● OGG1 ●

●●

● ITGB4 JUNB ●MYH11 ISG20 DEXI HIF1A KDM4B POU4F1 ● ● ABR ● ● PGM1 ● PTGIR ● ● TRH ● ● RUNX1T1 ● HPGDS ● HYAL2 ● NCALD PSD3 ● CD52 ● ● IL5RA CRIP2 ● SIPA1L1 ● ● CAV1 ● ● SLC25A1 MN1 CBFB ● ● ROBO1 PRAME CACNA2D2 BLVRA ● IL15RA ● ● ● ●

● HLA−DPA1 HLA−DMB HOMER2

●

BAIAP3 ● ADARB1 SPARC ● ●VAMP5 ●● ● ● HLA−DPB1 CD58 CD34 ATP2B4● SYNGR1 ●● CCND3 ● CLIP2 ● PTGER2 ● WIPF1

●

●

●

●

Pathway: SWEET_KRAS_TARGETS_DN There are 26 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FKBP2 Weight Factor: 1.347 Major Gene (NEG): TGOLN2 Weight Factor: 0.836

NEG ALL Major Gene (NEG): TGOLN2 Weight Factor: 1.253 Major Gene (BCR/ABL): FKBP2 Weight Factor: 1.199



FCGR2A LGALS3

●

TGFBI

SIRPA GABPB1

●

SHC1

●

GNS

●

LAMC1 GADD45A

● ACLY

●

MANF

● FKBP2

●

TSTA3●

MAPK1 ●

●

●

PSEN1

● GLRX VASP

●

GNS

SIRPA

●

GLRX ACLY

●

BSG MAPK1

VASP

●

TGOLN2 LAMC1

●

●

●

●

IL18

●

GABPB1

SHC1

●

●

PSEN1

●

NPC2

RABGGTB

●

● ●

●

●

TSTA3 MANF

FCGR2A

ATP1B1

CDKN1A

●

GADD45A

●

●

LGALS3 FKBP2 ●

●

ATP1B1TGOLN2●

●

● ●

●

BSG

●

●

TGFBI

IL18

●

PON2

BTG1 CDKN1A ● RABGGTB

●

●

●

●

●

PON2

●

NPC2

BTG1

●

●

Pathway: ROSS_AML_WITH_CBFB_MYH11_FUSION There are 44 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SLC7A7 Weight Factor: 1.524 Major Gene (NEG): CLEC10A Weight Factor: 1.05

NEG ALL Major Gene (NEG): CLEC10A Weight Factor: 1.401 Major Gene (BCR/ABL): SLC7A7 Weight Factor: 0.876



TGFBI NAGA MTMR11 CHI3L1 ● LPAR1 ● CD1E ● ● FYB ● QPCT

KIF17

● IL10RA CTSS ● CEBPD TNFAIP2 CD1E CCR2 LPAR1 MTMR11 NACC2PLXNB2 ● ● ● ● ● ● ● TGFBI● ● CLEC10A QPCT SLC7A7 ● LGALS2 NAGA ● ● CHI3L1 ● ● ● S100A8 S100A9 CFP MYH11 ● GRHPR PTPRM ● ● ● ● ● CYBB FYB ● TES CD1C ● PGM1 ● CD52 NRP1 ● ● ● SPARC ● ANXA11 ● ●ST18 MEGF9 ● MDFIC ● DUSP6 ● ●HPCAL1 IL13RA1 DYNLT1 MN1 KCTD12 ● ● ● ● ● ● CBFBMEF2A ● ●

●

● NACC2GRHPR SPARC CCR2 ● ● LGALS2 TES SLC7A7 ● ● KCTD12 ● MYH11 PGM1 ● ● CD1C

●

●

DYNLT1 ● ● CLEC10A ● DUSP6 NRP1 CFP ● MEGF9 CD52 ● ● ST18 ● ● CBFB MEF2A ● TNFAIP2IL13RA1 ● MN1 ● ● KIF17 IL10RA ● ● ● ● ● PTPRM ● HPCAL1 ANXA11 ● CEBPD CTSS ● S100A9 ● ● ● PLXNB2 ● S100A8● MDFIC ● ● CYBB●

Pathway: GNATENKO_PLATELET_SIGNATURE There are 31 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ITGA2B Weight Factor: 1.408 Major Gene (NEG): GNAS Weight Factor: 0.827

NEG ALL Major Gene (NEG): GNAS Weight Factor: 1.298 Major Gene (BCR/ABL): ITGA2B Weight Factor: 1.154



GPX1 SPARC

● ● TLN1

● RPL41

OAZ1 F13A1HIST1H2AC

F13A1

●

●

CD99

●

HIST1H2AC

TOP3B

●

●

GNAS B2M ● MLH3 ● TAGLN2 HLA−E ● NCOA4 HBB ● ● MYL12A ● CD99 CCL5 ● ITGA2B PTMA ● CFL1 ● CLU ● ● RGS10 ● ● PF4 PPBP ● ● TMSB4X ● ● ACTB

●

OAZ1

●

PPBP

●

CLU PF4● SPARC

● TOP3B FTH1

●

●

●

●

GPX1 TLN1

ITGA2B

● PGRMC1 ● FLNA UBC ● ● ●

●

●

● ● NCOA4 MYL12A

●

PGRMC1

●

● MLH3

B2M CFL1 ACTB ●

●

●

UBC

● FTH1

●

●

PTMA

●

●

●

HBB FLNA ● TMSB4X TAGLN2 ● ● HLA−E ●

CCL5

GNAS

●

RPL41

●

RGS10

●

Pathway: DER_IFN_ALPHA_RESPONSE_UP There are 56 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IFI35 Weight Factor: 1.378 Major Gene (NEG): MX2 Weight Factor: 1.09

NEG ALL Major Gene (NEG): MX2 Weight Factor: 1.351 Major Gene (BCR/ABL): IFI35 Weight Factor: 1.258



VEGFC

EIF2B1 CD164 ●● TRIM14

● SKP1 XRCC6 ● SHFM1NMI C1S ● ● SRP9 ● TRIM22 TRIM21 ● ●SSBP1 ATP6V0B ● ● BBC3 ● ●PSME1 ●IFITM1 TAP1 PLOD2 ● ADAR BST2 ● CSRP3 HLA−A ● ● ● RHOCPDXK ● ● ● ISG15 ● MAP3K10 STAT1 ● ● ● PML MX1● EPS15 ● IFI16 GMPR ● MX2 IFI35 ● RBBP4 ● OAS1 ● ●OAS2●HLA−E ● TEAD4 FAS ● ● ● POLR2B ● ● SMAD4 IL6 ● IRF2 CASP8IRF1 DDX17 ● IFIT3 ● ● ● PPP3CA ● COL16A1 ● SDCBP ● PMAIP1 ● ● ● BTG1 ● ● GBP1 BAG1 ● ●

●

BBC3

● TRIM14 BAG1 CD164 ●MAP3K10 ● ● ● NMI TRIM22 ● SRP9COL16A1 ● ATP6V0B HLA−A ● ● TEAD4 PSME1 ● ● VEGFC● XRCC6 EIF2B1 HLA−E ● TAP1 IFI16 SSBP1 SHFM1 ● ●TRIM21 ● GBP1● ● ADAR MX2 ●● ● ● C1S CSRP3 ● PML ● ● FAS ● ● PDXK OAS1 IFITM1 GMPR ● SMAD4 PLOD2 MX1 ● POLR2B ● ● ● ●EPS15 ● ● ● SKP1 ● ISG15OAS2 IL6 ● ● PPP3CA IFIT3 ● SDCBP ● ●BST2 ●

PMAIP1 CASP8

●

●

●

BTG1

●

●

DDX17STAT1 IRF2 ● IFI35 ●

●RBBP4●

RHOC

●●

IRF1

●

●

Pathway: KLEIN_PRIMARY_EFFUSION_LYMPHOMA_DN There are 57 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CAPG Weight Factor: 1.362 Major Gene (NEG): DEK Weight Factor: 1.022

NEG ALL Major Gene (NEG): DEK Weight Factor: 1.505 Major Gene (BCR/ABL): CAPG Weight Factor: 0.794



PKIG

BCAR3 CD27 CD79B CD52 SEL1L3 ● ● FADS3 ● PAWR KIAA0922 IRF8● ● ● ● ● DBICD79ANCF4 CD22 ● CD19 GATM CD24ZHX2 ST6GAL1●GSTP1 CAPG ● ● ● ● ● ● PTPN6 ● ● ALDH5A1● CD40 ● MSL3 STX7 ●AES MS4A1 ● ● ● CD72 ● ● MAPRE2 ● ETS1 SWAP70 SYPL1 ● ● BIRC3 ● BTG2 ● SPIB BLNK ● LRMP SH3BP5 ● ● ● ● ● VNN2 BCL11AID3 CCDC6 ● RASSF2 SCRN1 ● ● POU2F2 ● ● MMD ● ● CTSHFAM65BSIT1● ● HLA−DMA ● ● ●CXCR5 HLA−DQB1 ● DEK TRAF5 GPX7 ● ● ● HLA−DMB ● ●

●

●

GATM SCRN1

●

PAWR

●

CTSH CD27MS4A1 ● ● FAM65B ● BIRC3 SEL1L3 ● ● GPX7 ●

● NCF4

GSTP1 ●IRF8

CAPG

● ● TRAF5

BCAR3

● ● ●MAPRE2 SPIB CD79A ● ● ● ALDH5A1 HLA−DQB1 AES ● ● BLNK ● CD79B ● BCL11A ● ● ● HLA−DMA ● HLA−DMB DEK SYPL1 ● CD52 ETS1 DBI LRMP STX7 ● ● ● PKIG● MSL3 ● CD19 ● ● ● SWAP70 ●RASSF2 CXCR5 ● ● CCDC6 SH3BP5 KIAA0922 ● ST6GAL1 ZHX2 ● FADS3 ● ● ● ● ● ● CD72 POU2F2 ● BTG2 CD22 CD40 ● ● ●● ● ID3 MMD ● SIT1 CD24 VNN2 ● ● ● ● PTPN6

Pathway: TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN There are 37 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NFKB1 Weight Factor: 1.409 Major Gene (NEG): KIAA0430 Weight Factor: 1.332

NEG ALL Major Gene (NEG): KIAA0430 Weight Factor: 1.429 Major Gene (BCR/ABL): NFKB1 Weight Factor: 0.962



AXIN1 BLK

LTB

●

● BIN1

●

GCH1

●

●

●

IRF8

ELF4

●

●

RPS4Y1 CXCR5 TRIM22 ● ●

CD83 MS4A1 IL4R ● RHOG ● LPGAT1 SATB1 ● ITPR1 ● ● NFKB1 SERPINB1 ● ● CIITA MMD ● ● TGFBR2 KIAA0430 ● ● AIM1 ● RHOH ● NFKBIE● GPR18 ● MAPRE2 IFNGR1 ● CD37 ● ● ● ● GIT2

●

●

HHEX

●

●

HLA−DMB

●

LYL1 REL

●

●

LTB

RPS4Y1

●

● AHR

CCND3

BIN1

MS4A1

●

●

AHR

SERPINB1 CCND3 LYL1

●

ITPR1 AIM1

●

●

● CXCR5 GCH1 HLA−DMB MAPRE2 GIT2 ● ● TRIM22 HHEX

● ● CD37

CD83 NFKBIE

● RHOH IFNGR1 KIAA0430 ● LPGAT1 ●

IRF8

●

● ELF4 TGFBR2

CIITA AXIN1 ● MMD ●

●

●

RHOG ●

NFKB1

●

● REL

●

●

●

●

● ●

●

●

IL4R

●

●

GPR18

●

BLK

●

SATB1

●

Pathway: FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP There are 86 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TYROBP Weight Factor: 1.502 Major Gene (NEG): RAB31 Weight Factor: 1.283

NEG ALL Major Gene (NEG): RAB31 Weight Factor: 1.488 Major Gene (BCR/ABL): TYROBP Weight Factor: 0.907



IFITM1 AIF1 RHOH ●LAPTM5 CXCR4 FCGR1A UBC ● ● ADAM15TNFRSF1B RAB27A ● ●LST1 ISG20 ●RAB31 ● WARS KIAA0922 ● ● ● IFI30 ● ● FCN1● ● GAPDH COL6A3 CSTA CFD ● ● ● TYROBP FCER1G VSIG4 ● ● TYMP ● ● GZMA LILRB4 CD14 MMP9 ● ● IL10RA ● ● ● ● IL10RB STAT1 ● CCL5 RGS10 CD2 ●S100A8 SLA● CD48 LCN2 ● ● AOAH ● ●CD8A CD3D ● ● ● CORO1A ● C1QB CCND3 ● ● ALDOC ● ● RAC2 ● MOXD1 ● ● TRBC1 LCK CD27 RBMS1 LTF ● ● S100A4 ITGB2 ● PSMB8 ● ●POLR2A ● ● ●RASSF2 ENTPD1 ● ● SFN ● GBP2 PTPRC ● ● IL4RCELF2 ●ACTBPDE6D● APOC1 LY86 CD52 ● CD163 ● ● PIM2 ●● ● PRKCB FABP5 EIF2AK2 INPP5D ● ● DARC ● UBE2L6 ● ●GMFG ● ● CD53 USP9X HLA−F HCLS1 ● ● ● ● GLUL ● ● LGALS9 ● ● ● DOCK2 ● LCP1

●

● ●

RAB27A IL4R ● CD2 ● CD8A IL10RA GZMA ● PTPRC ● ● ●CCL5 CSTA S100A8 FCN1RGS10 LCK ●CD3D FCER1G ● ● ● CD14 TRBC1 COL6A3 ● ● ● ●AOAH TYROBP ● UBC ● ● ● ●MOXD1 APOC1 CORO1A CD48 ●CD27 LILRB4 CFD ●RAB31 LCP1 ● ITGB2 ● ● C1QB POLR2A ● ●IFI30● ● GBP2ADAM15 ALDOC ● ● RBMS1 ● AIF1 ● MMP9 RASSF2 ● ● EIF2AK2 S100A4 ●DOCK2 ● ●TYMP ● KIAA0922 LAPTM5 LST1 ● TNFRSF1B ● GAPDH INPP5D FABP5 ●GLUL IL10RB ● ● ● GMFG ● ● LCN2 ● ●LY86 IFITM1 ● USP9X ●HLA−F ● WARS ACTB ENTPD1 ●DARC ●● ● CD53 PIM2 VSIG4● RHOH RAC2 ● ● ● ● ●STAT1 ● ● ● ● ● HCLS1 ● CD163 ● CXCR4 ISG20 ● PRKCB ● CD52 LTF SLA ●● CELF2 ● ● ● FCGR1A PDE6D ● ● ● UBE2L6 PSMB8SFN CCND3

●● ● ● ● ● ● LGALS9 ●

Pathway: WIELAND_UP_BY_HBV_INFECTION There are 79 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): WARS Weight Factor: 1.311 Major Gene (NEG): PSMB9 Weight Factor: 1.196

NEG ALL Major Gene (NEG): PSMB9 Weight Factor: 1.405 Major Gene (BCR/ABL): WARS Weight Factor: 0.768



IFI16 RFX5 CD53 ● ● IFI27 ● ● C1QB LGALS3 S100A10CCL5 ● CD68GPNMB HLA−F ● ● TRBC1 CXCL10 ● CD48 ● IFI30 ● ●● CXCL11 TYROBP EMR1 ● CXCL9 ● FCER1G ● ● PIK3CD ● ●SLC7A7 GZMA CD3D ● ● RAB27A ● CTSB WARS KPNA2 ● ● ● GZMK RAB31 GM2A ● ● ● IL10RA ● ● TAPBP● ● FGL2 ● VSIG4 TPP1 ARHGDIB IGSF6● ● ● RARRES3 CXCR4 LAPTM5 ● HLA−DPA1 ● CFL1 RAC2 ● ● HLA−A HLA−DPB1 PPT1 ● PSME1 ● CD74 HLA−DRA ● LPXN ● CD83 ● TRIM22 ● HLA−DMB ● ● ● PSMB10● UBE2L6 ● PSMB9 ● ● CD38 SP110 ● AURKA ● UCP2 ISG20 ● HLA−E STAT1 ● ●● ● ● ● ● CTSC●PSME2 ● ● PTTG1 ● B2M GBP2 ● MCM6 CD5L TYMS ● GBP1 ● RRM2UBE2C ● ● ● SRGN ● ● ● ● SOD2 C3AR1 RGL1

●

●

●

SLC7A7 IFI30

● ● CD48 RARRES3 TYROBP

CTSC ● ● ● GZMK CFL1LAPTM5 GZMA FCER1G ● FGL2 CCL5 ● ●CD3D ● S100A10 ●PSMB10 ● ● ARHGDIB ● TRBC1 STAT1 TAPBP ● WARS IL10RA ● B2MRAC2 ● PSME2PIK3CD ●CXCL10 ● ●RAB31● ● PSMB9 ● ●RAB27A ● ● PSME1 GM2A ● ● HLA−A SRGN ● LPXN ● EMR1 ● KPNA2 UBE2L6 ● CXCL9 ● ● ● CD83 C1QB ● CXCR4UCP2 LGALS3 CD68 ● CTSB ● GBP1 ● GPNMB ● IFI27 VSIG4 ● ● ● SP110 ● HLA−E ● CXCL11 ● ● ●TRIM22 ● ISG20 ● ● CD38 ● IGSF6 HLA−DMB CD53 ● HLA−DPA1 ● ● TPP1HLA−FRFX5 HLA−DPB1 ●CD74 CD5L C3AR1 ● ● ● ● ● ● SOD2 HLA−DRA RGL1 ● IFI16 ● ● ● ●● PPT1● ● ● UBE2C ● PTTG1 ● AURKA GBP2 ● MCM6 ● ● ● ● TYMS ● RRM2 ●

Pathway: DER_IFN_BETA_RESPONSE_UP There are 81 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IFI35 Weight Factor: 1.331 Major Gene (NEG): PTPN11 Weight Factor: 1.207

NEG ALL Major Gene (NEG): PTPN11 Weight Factor: 1.426 Major Gene (BCR/ABL): IFI35 Weight Factor: 1.178



ARID3A PLOD2 ● ADAM9 ●BTG1 PPP3CA HIF1A PMAIP1 ● STAT1 ● ● BST2 ● MX1 ELF1 MX2 PDXK ELK4 RHOC● ● IFI35 ● OAS2 HLA−E ● ● CEBPD CASP8 ● ● ●GBP1 ● SMAD4 PPP5C ● IRF2 ● OAS1 MAP1B IL6 ● ● ● ISG15 ● ● ● POLR2B ●HLA−A TRIM22 ● RBBP4 PLAURPML ● DDX17IFI16 ● FOSL1 MAP3K10 ● ETS2 ● ●IFIT3 ● ● TAP1 ● ● ●●HADH ● ● EIF2AK2 ● SSBP1 ● ● EPS15 PSME1 ● SRP9 ● ADAR PARP1 ● ● ATP6V0B ● ● ●NMI CSRP3 IFITM1 IRF1 DDX1 ● EPRS ●SHFM1 SKP1● BAG1 ● ● ● ● HADHB ●● ●TRIM21●XRCC6 PTPN11 TRIM14 ● IQGAP1 IFIT5 ● ●CD164 PHLDA1 ● ● CALD1 DDX21 PARP4 AP3M2 C1S ● ●EIF3A ● ● ●EIF2B1 ● ● TRAPPC10 ● ● DNAJC2●FUBP1 CTR9 GMFB ● ● ● ● ●BCLAF1

●●

HADHPSME1CALD1 ● DDX17 ●SSBP1 EPRS PML ● HLA−E ● IFIT3 BST2 ● SHFM1 IRF1 STAT1 ● PARP1 ● PDXK ●OAS2 ● ● HLA−A● ISG15 ● ● MX1● IFIT5 ● ● EIF2AK2 ADAR DDX1 ●IFITM1 OAS1 ● ● ● CTR9 IQGAP1 ● ●MX2 ●SRP9 PARP4 ● TAP1 ● TRAPPC10 IFI35 ● ● TRIM14HADHB ● ● ● ● PHLDA1 TRIM22 NMI ● ● ● PTPN11 ● CD164 GBP1 RBBP4RHOC ● FOSL1 ● ● EIF2B1 MAP3K10 PPP5C IRF2 ● ● ● ● ● ●● IFI16ARID3A ● ● ● PPP3CA PLOD2 TRIM21 ●MAP1B ● C1S ● ● SMAD4 CSRP3 ● CASP8 ● IL6 SKP1 AP3M2 ● XRCC6 ● GMFB ● ● ATP6V0B ● ● FUBP1 ●POLR2B EPS15 ● DNAJC2 DDX21 ●BCLAF1 EIF3A ● ● BAG1 PLAUR ● ● ● ELK4 HIF1A ● ● ● ● ● ● ADAM9 PMAIP1 ● CEBPD ● BTG1 ● ELF1ETS2

●

●

● ●

Pathway: FRASOR_RESPONSE_TO_ESTRADIOL_DN There are 62 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): BCAS1 Weight Factor: 1.296 Major Gene (NEG): BMP4 Weight Factor: 1.167

NEG ALL Major Gene (NEG): BMP4 Weight Factor: 1.325 Major Gene (BCR/ABL): BCAS1 Weight Factor: 1.081



INPP5JBAK1 EPOR RAP1GAP

●

●

●

MUC1TGFB2 ● SELENBP1 MYO1B BIK ● KRT81● INHBB ● ● ● ● KRT7ASB9 ● DUSP4SMPD1 NELL2● ● ● PXDN ● PLK2 DUSP1 CLU ENC1 ● ● ● INSIG2●IER3KLF6 ● SLIT2● ●CTSH BLNK CTSL1 ● ERBB2 ● LAMB2 ● BMP4MMD GPRC5A ● SMAD3● ● ● ● ●ABCC5 LITAF ●● ● BCAS1 CD24 NDRG1 ●FOLH1 ● ARNT2 ABCG1 ● ●

●

GNE KIAA0922 ● ● IL1R1● RND3 GNS ● ALDH4A1 STC1 STXBP1 ● ● MXD4 ● FMO5● ● DBN1 ● COL4A5 ● ● EFNA1 ANXA3 PRPS1 TTC9 ● ● ● ● MATN2 LHFPL2 ● ● PPP1R3C ● LAMB1 ●

●

●

●

CTSL1 SELENBP1 ABCG1 ● LAMB1 ● ● IER3 LHFPL2 MMD ENC1 ● ●

● ● GNS ● ● DUSP4EFNA1 NELL2 LITAF ● NDRG1 ● BLNK ●MYO1B ● KRT7 ASB9 ● ●

INSIG2 PLK2

●

●

KLF6 SMPD1 KIAA0922 ● ●CD24 ●GPRC5ACLU ● RAP1GAP

● ● ● ● ARNT2 ● ●BMP4 CTSH BCAS1 SLIT2 SMAD3 INHBB ● MUC1 ● INPP5J● LAMB2 ● ● ● ● KRT81 ● ● STXBP1●ERBB2 ● BAK1 GNE ● ABCC5 PPP1R3C ● MXD4 IL1R1 ● BIK ● PXDN ● ● ● DUSP1ALDH4A1 STC1 ● TGFB2 ● ● FOLH1 COL4A5● ● ● FMO5 ● ● MATN2 DBN1 ● TTC9 RND3 ● EPOR ● ANXA3 ● ● ● ● PRPS1 ● ●

Pathway: TENEDINI_MEGAKARYOCYTE_MARKERS There are 50 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): GATA1 Weight Factor: 1.335 Major Gene (NEG): GP9 Weight Factor: 1.239

NEG ALL Major Gene (NEG): GP9 Weight Factor: 1.528 Major Gene (BCR/ABL): GATA1 Weight Factor: 0.996



PDGFA CBFA2T2

●

CDK2

●

JAK2 CDKN1B RASA1 ● JUND ● MAPK14 ● ● BCL2 BAD IL11RA IL3RA ● ● CASP3 STAT1 ● MCL1 KIT CBFA2T3 MECOM ● ● ● GP9 ● STAT3 MPL ● ● MYC ● ● ● FOS ● MYB ● ● CD9 CCND3 ● ● FLI1 CASP9 BAK1 VEGFA ● GATA1 CDK2 BCL2L2 ● ● CCL5 ● CDKN2A ● ● PDGFB ● ●ITGA2B ● ● ● IL6R STAT5A TGFB1 ● ● ● GP1BA PF4 IL8 TAL1 IL11 IL1R1 ● ● ● ● CXCL1 ● ● ● ● IL1B ● ● NFE2 IL6 ● PIK3C2B ●

●

● CASP9 MYB CCND3 VEGFA ● STAT5A

STAT1 ● ● IL3RA ● ● FLI1 STAT3 CBFA2T3 JUND ● MCL1 IL8 ● ●MAPK14 CBFA2T2 IL6 ● ● PIK3C2B ● ● BCL2 FOS ● ● ● IL1B ● PDGFA ● ●BCL2L2 ● TGFB1 GP9 ● IL1R1 ● RASA1 CD9 ● CDKN1B ● ITGA2B ● ● ● BAD ● CASP3 PDGFB ● NFE2 ● ● GP1BA GATA1 CCL5 ● BAK1 ● KIT JAK2 ● IL11RA ● ● PF4 ● ● ● TAL1 IL6R ● ● IL11 ● ● CXCL1 MECOM MPL ●

●

●

●

●

CDKN2A MYC

● ●

Pathway: ROSS_AML_WITH_MLL_FUSIONS There are 60 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PLD3 Weight Factor: 1.45 Major Gene (NEG): COL9A2 Weight Factor: 1.219

NEG ALL Major Gene (NEG): COL9A2 Weight Factor: 1.469 Major Gene (BCR/ABL): PLD3 Weight Factor: 1.187



SYT17 HEXB

● LRMP

● HOXA5 ● SIRPA ● GGA2 COX8A ● ● ADCY9 COL9A2 SLC9A6 ● ● MLL ● MBNL1 ITGA7 ● FEZ1 FES ● ● APOC2 ● RNASE2 FBP1 ● DACH1 PBX3 ● ● CCL23 RNASE3● CTSL1 ● ● TDRD7 ● HK3 ● STXBP2 MEF2C ● ● ● ● RPS6KA5 SRGN ● SOCS2 ● ITGAX ● ● ● ● ● DEXI PLD3 MVP BLOC1S1 ALOX5AP CUL1 TPP1 ● LGALS1NKG7 ● ● CPM ● ● CCL5 ● ● ● ● RPL22 ● ● LY86 ● ● ANXA5 RNH1 CAPG● ● ALDH3A2 ● ● ALDH3B1 AK2 GUSB RNPEP ● PGAM1 ● MRPL33 ● ● PHKA2AKR7A2 ● ● ● ● ● ●

CES1

C2

GLG1

●

ALOX5AP GUSB ●

GAS7

● RNPEP

RPS6KA5 RNASE2 COX8A ANXA5 ● ● ● ALDH3A2 ● CCL23 RNASE3 HOXA5 CTSL1 ● CES1 PHKA2 LY86 C2 ● ●SRGN TDRD7 ● PGAM1 ● LRMP ● ● ALDH3B1 ● ● ● ●COL9A2 ● ● SLC9A6 CUL1SIRPA ● GAS7LGALS1FEZ1 APOC2 CPM ● ● ● ● MBNL1 ●ADCY9 ● ● ● ●FBP1 CAPG RNH1 PBX3 ● SOCS2 ● GGA2TPP1 ● HEXB PLD3 STXBP2CCL5AKR7A2 ● ● ● ● ● ● MRPL33 ● MLL ● ●● BLOC1S1 ● NKG7 MEF2C ● ● SYT17 FES ● HK3 ●● DEXI

●

●

●

●

●

MVP ITGAXAK2 GLG1DACH1 ● ● ● RPL22 ● ● ITGA7

●

●

Pathway: CHEOK_RESPONSE_TO_HD_MTX_UP There are 21 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): S100A9 Weight Factor: 1.319 Major Gene (NEG): BAX Weight Factor: 1.036

NEG ALL Major Gene (NEG): BAX Weight Factor: 1.347 Major Gene (BCR/ABL): S100A9 Weight Factor: 1.147



MYLK

● OLFM4

●

CTSG

●

● S100A9

●

●

●

ARL4C

CTSG

●

●

●

HHLA1

● SLC1A4

●

ABLIM1

●

OLFM4

●

●

IL32

S100A8

●

TRBC1

●

ABLIM1

AZU1

●

BAX

DEFA4

NFKB2

●

ARL4C

●

●

AZU1

●

BAX

●

FLNA

●

●

TRBC1

●

NFKB2

HHLA1 ATM

IL32

●

●

●

ANXA2

●

TYROBP S100A8

DEFA4

●

MPO

●

MYLK

S100A4

●

ATM

●

S100A9 ●

● ANXA2

S100A4

SLC1A4 ●

●

● MPO

●

FLNA

●

TYROBP

●

Pathway: WONG_IFNA2_RESISTANCE_DN There are 15 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): LZTR1 Weight Factor: 1.304 Major Gene (NEG): TTR Weight Factor: 0.873

NEG ALL Major Gene (NEG): TTR Weight Factor: 1.307 Major Gene (BCR/ABL): LZTR1 Weight Factor: 1.178



ZNF185 DUSP3

IDUA

●

TTR

●

●

PSMD8

●

EMR1

●

● PAK7 ZNF185

●

●

●

HMGN1

●

PSMD8

HNRNPF

●

HMGB1

●

●

LZTR1

●

POR

●

HNRNPF

HMGB1 LZTR1

● TTR

EMR1

●

IDUA

●

●

●

●

● DPF2

HMGN1

NOP56

DUSP3

●

●

POR

●

●

NOP56

PAK7 FOXF1

●

FOXF1

●

●

DPF2

●

Pathway: ROSS_AML_WITH_AML1_ETO_FUSION There are 53 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HYAL2 Weight Factor: 1.451 Major Gene (NEG): ARHGAP1 Weight Factor: 1.416

NEG ALL Major Gene (NEG): ARHGAP1 Weight Factor: 1.495 Major Gene (BCR/ABL): HYAL2 Weight Factor: 1.421



TBXA2R

● VOPP1 ●

●

ENDOD1 ● ROBO1

ISG20 HIST1H2BI PTGIR CCND1 VAMP5 ● CACNA2D2 EPCAM RUNX1T1 ●● CIITA ● ● ● LAPTM5 RGS10 IER2 IL5RA ● CD34 ● ● BAIAP3 TCN1 ● ● HIST1H2BF ● ● ● ● SHC1 ● PALM NCALD ● ● USP10 ● LCP1 RPS6KA1 PRAME ● CAV1 ● HPGDS ● ● POU4F1 ● ● SLC25A1 ● DISC1 ADRM1 ACSM3 ● ARHGAP1 CD58 ● MAN1A1 ●HIST1H2BD ● ● ● ARHGEF6 ● KDM4B ● CD19 HYAL2 ● KLF11 ● ● ● MKNK2 ITGB4

●

● ● ● TRAF3IP2 ● AP1B1 PTPN12 PSD3 ITPR1 ● ● ● ● ● SCML2

●

ENDOD1

TRH EPCAM SLC25A1 TBXA2R KLF11

● ● ● VOPP1 ACSM3 ●TRAF3IP2

● USP10

●

DISC1 POU4F1

●

CIITA

●

TCN1 CAV1 ● RPS6KA1 ●SCML2 ● KDM4B TRH ● ● ● ROBO1 ● ● ● CD19 ● IL5RA CD34CACNA2D2 HPGDS ● ARHGAP1 BAIAP3 ● ● ● CD58 ● LCP1 ARHGEF6 ● RUNX1T1 CCND1 ● ● ● ITGB4 ● ITPR1 ADRM1 AP1B1 ● HIST1H2BD ● SHC1 ● ● HYAL2 ● ● ● ● NCALD ● ● VAMP5 HIST1H2BF ISG20 PTGIR ● PRAME ● ● ● LAPTM5 ● ● MKNK2 PTPN12 RGS10 ● PALM ● IER2 ● ● HIST1H2BI ● PSD3 ● ● MAN1A1 ●

●

Pathway: HASLINGER_B_CLL_WITH_11Q23_DELETION There are 19 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): UBE4A Weight Factor: 1.257 Major Gene (NEG): BIRC2 Weight Factor: 1.217

NEG ALL Major Gene (NEG): BIRC2 Weight Factor: 1.364 Major Gene (BCR/ABL): UBE4A Weight Factor: 1.308



PPP2R1B

● ● CSPG5

●

●

●

UBE4A CTSK

●

●

●

AHR

●

PCSK7

●

●

AHR

●

●

GLRA2

PPP2R1B

● CNR1

●

DDX10

●

BIRC2

●

BIRC2

●

PCSK7

ATM

● PABPC4

●

PABPC4

CASP1 PICALM

UBE4A

●

●

GLRA2

●

● PICALM

HS3ST1

●

DDX10

ADRBK2

●

SLC4A7

ADRBK2 CNR1

●

HS3ST1

●

FUT8

GSN

●

●

CSPG5

●

FUT8

●

●

SLC4A7

●

GSN

●

CASP1

● ATM CTSK

●

●

Pathway: HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN There are 66 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FGR Weight Factor: 1.366 Major Gene (NEG): PHLDA1 Weight Factor: 1.08

NEG ALL Major Gene (NEG): PHLDA1 Weight Factor: 1.629 Major Gene (BCR/ABL): FGR Weight Factor: 1.109



DUSP1 SLC11A1 FPR2 MSR1 ● ● KLF4FOS● ● EGR1 NR2F6 C3AR1 IL5 ● ● ● SIRPADAB2 ●CXCL2 ● PHLDA1 ● PLSCR1 IL1R2 ● ● EHD1IL1B ●UPP1 AQP9 ● CTSL1 FPR1 MMP9 P2RY14 ● ● ZFP36 HIST1H1C ● ● ● ● ● ● ANXA4 ● ● ● PLEK LITAF MCL1 ● ● ZFP36L1 ● MRC1 ● LCN2 BTG2 ● ANXA1 ●TLR2GRK5 ● ● MITF EGR2 ● VCAN ● ● ● ● ● NOV ●PSAP CYBB LIPA LPL ● GCNT2 TPD52CCR5 FGR MERTK CSF1R TGFBI ● ● ● ARG2 NDRG1 SAMHD1 ● ● ● CTSS ● ● IL18 ● ● ● ● ● ● ● CDH1 HCK MMP8 ● S100A4 ● TERF1 ●

●

CPT1A

●

ID2

●

●

LSP1STX3

● ●

●

LITAF UPP1 GRK5 EHD1

TERF1 P2RY14

● ●

●

●

●

●

ZFP36L1 VCAN MMP8 EGR2 HCK ● IL5DAB2 ● ● AQP9 ● NOV ● ● ● ● ●IL1R2 BTG2 ● CTSL1SAMHD1 MRC1 TGFBIFGR IL18 ● ● MERTK CSF1R MITF ● MSR1 ● CTSS ● ●STX3 ● CCR5 ●CYBB ● ANXA1 ● ● S100A4 ● PLEK ● ● ANXA4 SIRPA ● ● TPD52● ● MCL1 FPR1 ● LIPA ● LCN2 ● MMP9● ● SLC11A1 PHLDA1 CXCL2 ● ●● DUSP1 ZFP36 ● ● ● ● LSP1 LPL ID2 FPR2 CPT1A ● NDRG1 ●HIST1H1C KLF4 ● ● C3AR1 ● IL1B ● ●NR2F6 ● CDH1

●GCNT2 ● FOS ● ● ●PSAP EGR1ARG2 PLSCR1 ● ● ● ● ● ● TLR2

●

Pathway: FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN There are 74 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MCM2 Weight Factor: 1.465 Major Gene (NEG): HPRT1 Weight Factor: 1.354

NEG ALL Major Gene (NEG): HPRT1 Weight Factor: 1.477 Major Gene (BCR/ABL): MCM2 Weight Factor: 1.14



KHSRP LST1 ● RFTN1 APLP2FYB HBB ● ● ● BCLAF1 ● ● S100A4 PLP2 PTP4A2 HPCA SLC9A1 ● MX2 ● ● SLC1A5 ● ● GCGR PKMYT1 ● MAPKAPK3 CD2 ● TCEB1 ● EEF1D ● ● SLC29A1 ● BARD1 EPS15 TXN ● GAPDH ● PSMA2 ● HINT1 ● POLA2 TRIP12 PSMB2 MYC ● PRDX6 ● ●● ATP5G3 ● STRA13 ● ● PLCB2 ● ● ●LBR ● FKBP5 USP10 ● HPRT1 ● ● GLUL● MCM5 TMEM131 NUP93 ● ● PCNA SORD● VBP1 ● ● ● HADH PSMA6 AP3S1 CSE1L● PPP2R2A ● ● ● ● DUT CHAF1A ● ● TOP2A ● KPNB1 ● HMGB2 ITPKA POLD2● RANBP1 CDK2 SDHA ● ● ●● ACAA2 ● ● MCM2 ● ● KIAA0101 EIF3B ● UBE2S ● ●UBE2C RPS4Y1 TFDP2 RRM1 ● ● ● PGAM1 ●● ● ● GOT2LMNB1 ● DOCK2

● ●

●

ITPKA RPS4Y1 UBE2S ● STRA13

●

●

PKMYT1 MCM5 ● SLC29A1 APLP2EEF1D PCNA ● POLA2 ● SLC1A5 ● ● ● POLD2 TFDP2 ●UBE2C MYC● ● FKBP5 SLC9A1 ● ●CDK2 ● ●ACAA2 CHAF1A GAPDH MCM2 ● GCGR ● ● MX2 ●TOP2A● ● HPCA ● ● NUP93 PSMB2 ● GLUL ● USP10 HADH ● TMEM131 PSMA6 DOCK2 ● TXN ● ● PGAM1 ● ● KIAA0101 ● CSE1L ● ● SDHA PRDX6 ● CD2 ● RANBP1GOT2 ● ● HMGB2 RRM1 ● ● LBR PLP2 DUT●SORD ATP5G3 BCLAF1● ● ●EIF3B ● PLCB2 KHSRP HPRT1 ● ● ● PSMA2 ● EPS15 ●● ● TRIP12 ● ● ● ● PPP2R2A VBP1 BARD1 KPNB1 HBB ● TCEB1 ● ● S100A4 ● ● ● AP3S1● HINT1 ●PTP4A2 LMNB1 ● ● FYB RFTN1 LST1 MAPKAPK3 ●

●

●

●

● ●

●

Pathway: HADDAD_B_LYMPHOCYTE_PROGENITOR There are 214 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ZMYM2 Weight Factor: 1.432 Major Gene (NEG): KIAA1033 Weight Factor: 1.355

NEG ALL Major Gene (NEG): KIAA1033 Weight Factor: 1.591 Major Gene (BCR/ABL): ZMYM2 Weight Factor: 1.339



TGIF1 JMJD1C PPM1A P2RX5 PLXNA2 ●MAP4K4 AKAP12 DYRK2 CEP135 SIAH2 ELF2CALM1 ●PPM1B RBM6 CTBP2 ● ID3SNTB2 ● BTG1 SEMA6A MYLK ● ● FOXO1 ● ● SECISBP2L LAPTM5 ● ● ENTPD4 ● TLE4 ● MOG ARHGEF7 ● ● RB1 RB1CC1 ● ●● ● ● ZHX2 NID2 ● KCNJ2 PKN2 AGFG1 ●UGCG SSBP2 ● LRIG1 ●●●BARD1 PPP3CC ● CRIM1 ● DCK BTG2 PRDM2 ARID5B ● SLC35D1 ● IRF4 SMARCA4 ● ● ● ZFP36L1 ● CXCR4 ARAP2 ● ITPR1 PTPRE COBL ● ZMYM2 HLA−F ● PKD2 ●● ● ● PIK3CD ING1 ● ●● IGF2R ● ● KIAA0922 ●PHF15 HCP5 ●SOD2 ●●P2RY14 ● ● MEF2A TIA1 ZFYVE16 IL1A ● BTN2A1 ● ● EZR CITED2 ● RASGRP1 MSX1 ● E2F5 FMR1 TLE1 ABCG2 SOCS2 ● ● ● KIAA1033 ●CD69 PCBP2 ● TMCC1 MPPED2 ● RASL10A PDS5B ● ELK3 SNN ●● ●LRMP ●●TRIM38 ●● EFHA1 ●CDKN1B WSB2 ● ● SPTA1 ●●MLL ●RRM2 ● TOB1 ●● ALOX5 ● ● TCF4 POU2AF1 ANAPC5 CACNB3 ●● ● ● GH1 CDKN2C ● SPPL2B ●HS3ST1 ● ISG20 RHOB ●USP34 ●● DNTT KAT2B MME ● ATM CD27 ● AP1B1 CD9 ● MEF2C ● ● TOP2B ●GLRX PION ● VAMP1 HIST1H2AC ● HIST1H2BD SNX2 RAG2 ● ●●ATR DCP2 ●ZNF423 ● EDEM1 IRS2 ● ● IRF2 ● ● ● MDM1 ● ● HIST1H1C RIMS3 ● ZNF160 ● CD79B ● ● LONP2 TUBA4A ●●● BLNK ● LILRA2 JUN ● ● ●DDR1 HIST1H1E ● WFS1 ● GADD45G ● ● TOP2A ● CDK13 ● ● PCDH9 HMGB2 ●LEF1 IGLL1 ● STK38 ● LILRB2 HIST1H2AM ●●● ● CD24 ● ●VPS13A GPR125 RAG1 ● RAD52 CYFIP2 CD79A ATAD2B CORO2B ●● VDAC1 ● ● HIST1H2AL ZNF135 ● ● ● HIST1H2BF ALDH5A1 ● ● ● ●FAM134B ● N4BP2L2 ● P4HA2 ● PXDN ● ●HMHB1 ● CAPN3 PCNA ●TCL1A FAIM3 ●HIST1H2BI ●●CD19 PSD3 ● ●● HIST1H4B TCF3 MLXIP ●●CHST15 CD22 GPM6B ● PPFIBP1 RNFT2 ● ● DDX3Y NPY ● ● ● EIF1AY ● AK1 ●● BLK RPS11 ●● ●EFNB2 ●DBN1 CIITA ● ●AUTS2 ●CD72 FHIT ●● AEBP1 ● ● MS4A1 ● ● PTPRK ● OR7A5 ● ● ● TCL1B ● ● HRK KDM5D FAM171A1 IL7R ● ● ● ●● ●GNG7 ●●TRIB2 ●● ● ● SMAD1 ● CAV1 ● TPD52 ● ● ● POU4F1 ● ● ●

●

OR7A5 HMHB1 ANAPC5 SMARCA4 ● P2RY14 ● TUBA4A CD19 CYFIP2 PTPRK ● ID3SIAH2RIMS3 PIK3CD CD24 FAM171A1 ● ● E2F5 ●AEBP1 ● ● EFNB2 ZFP36L1 DBN1 ● ● ISG20 AKAP12 MPPED2 ● ● DDR1 TCL1A WSB2 EDEM1 ● ●POU2AF1 GLRX TRIB2 KIAA0922 ● ●● JUN ● ● ● ● LAPTM5 ● ● AP1B1 ● MS4A1 ● ●N4BP2L2 CD69 SMAD1 NPY ● ●GPR125 LEF1 SEMA6A LILRA2 RASL10A IRF4 CHST15 BTG2 PCDH9 ●●MLXIP CDKN2C ● ITPR1 ●●HIST1H1C ●●TCF3 HIST1H2AM ● ●●MME ●●IL7R EIF1AY CD79B DDX3Y ● ARID5B FAM134B ●● ● ● ● LRMP ●● JMJD1C ● ● BLNK ● BLK PSD3 LONP2 GPM6B ● ING1 CD27 HIST1H2BD P4HA2 ● WFS1 AUTS2 SOCS2 ● HIST1H2AL HIST1H2AC ● TCF4 ● COBL ● ● KDM5D ● ● ●● ●● SSBP2 ● HIST1H2BF DNTT DCK ● ● ● ● HIST1H4B ZNF423 RAG2 ● PHF15 ● SPTA1 ● CRIM1 CAPN3 ● ● PKD2 PPM1A ABCG2 ●MAP4K4 ALOX5 ●ZNF160 PKN2 ● ●● ● ● ELK3EZR ● ALDH5A1 CIITA PCBP2 ●ATM ● ● ●ZFYVE16 HIST1H2BI ● TIA1 MDM1 AGFG1 ● ● ● ● ● ● CD79A ● ●DYRK2 ● RB1CC1 SLC35D1 CD9 SECISBP2L ●MSX1 RAG1 ● PRDM2 PION SNX2 ●POU4F1 ● IGF2R TCL1B ELF2 ● PTPRE RB1 ●● FHIT HLA−F ●FAIM3 ENTPD4 KIAA1033 ● SNN HMGB2 ● ● ●P2RX5 PPP3CC USP34 ● ● PXDN HRK TMCC1 ● ●UGCG MYLK CACNB3 ●ATR ●ARHGEF7 ● GADD45G ● ● MLL ● PPFIBP1 CITED2 ● ● ● ● ● TLE1 ● ● ● ● ● CDKN1B ● CXCR4 PPM1B ●●IGLL1 FMR1 ● PDS5B ●● ● RASGRP1 ●EFHA1 CTBP2 ● TGIF1 ●● ZMYM2 ● CEP135 ●HCP5 VAMP1 ●SOD2 TOB1 ● STK38 ●● BTG1 ●RHOB PLXNA2 IRF2 ● ● ● ● ● ● ●● ●TOP2A LRIG1 ARAP2 DCP2 ● ● ● ●● GH1 ● ●RRM2 HIST1H1E FOXO1 ●IL1A NID2 ● ●ZHX2 KAT2B ● ● ATAD2B CORO2B ● ● ● CALM1 IRS2 ● GNG7●TLE4 ● ●MEF2A ●PCNA ● ZNF135 CDK13 BARD1 SNTB2 ● ● LILRB2 SPPL2B ● ● ● RNFT2 ● ●● TPD52 MEF2C ● ●KCNJ2 ● ● ●● ● ● ● CD72 CD22 ●RPS11 RBM6 MOG VPS13A BTN2A1 ● ● ● ● VDAC1 RAD52 ● ● ● ● HS3ST1 ● ●●● ● AK1 TOP2B TRIM38 CAV1 ● ●

●

● ●

●●

Pathway: VERHAAK_AML_WITH_NPM1_MUTATED_UP There are 144 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CD14 Weight Factor: 1.5 Major Gene (NEG): PHLDA1 Weight Factor: 1.063

NEG ALL Major Gene (NEG): PHLDA1 Weight Factor: 1.54 Major Gene (BCR/ABL): CD14 Weight Factor: 1.223



LGALS3BP ABCC4 SORT1 PRDM2 BCL6PHKA2 RASGRP3 ● ● ADCY2 FPR1 SOD2 ● ● ● ● ABHD2 DEFB1 HIP1 ● CAT ● KCNJ2 LAPTM4B SAT1 ●G0S2 ● ● PLAUR IER3TNFAIP3 C3AR1 HOXB5 ITGB3 ● ● ●CCL1 C1QB EREG CTSL1 CXCL10 ● IL6 ● ● ● CCL4 ● FTO LTBP1 ● ● BASP1 AQP9 ● ●● ● GCH1NAMPT ●CD300C QPRT ●BCL2A1 PPBP ● ● ● TNF ● LMNA ● ● ACSL1 PF4 JAG1 CXCL3 ●IL1B HNMT ● ● ● SECTM1 ● ● ● CLU ●CXCL2 PTX3 NFKBIA CASP1 ● ●●LILRA3 PTAFR ●●MMP2 CCL20 ●● ●SERPINB2 ● ● CYP1B1 TRIB1 CCR1 FBP1 ETS2 ● ● ● ● PLEK ● ● FCN1●CX3CR1 CAMK1 CD36 HOXA10 EPB41L3 ● HOXB3 ● ●CD163 ● TNFSF10 ● ● ● HOXA5 ● SMPDL3A THBS1 ● HOXB6 CPVL ●PHLDA1 ● TNFAIP2 CAST ●FCGR3B LILRB3 ● ● ●HMOX1 ● SPINK2 LILRA1 ● ● ARHGAP22 CD14 ● ● ●SMC4 ● ●● SERPINA1 ● HK3 ● ●FGL2 VCAN TCIRG1CCL23 DMXL2 ● PRKAR2B FGR ● ● PBX3 ● CD86 ● ● ● ● GNS EMR1 LILRB2 LGALS2 ● MVP ● HIST2H2BE ●● ● ● WARS ● CTSG ● ● ●TRIM16 ● ● IFI30 TYMP TBXAS1 SCO2 ● NFKB2 ● NINJ1 ● COL4A5 ● ●IGF2R IRX5 ● ●SLC16A3 ● CTSD C2 AIM2 ● HCK ● ● ● CHST15 ●HOXA4 VNN2 HOMER3 HIST1H1C ●MARCKS ● ● ● ●● PLS1 HIST1H2BC ● ● ● STS LILRB1 RUNX1 ●● FOXC1 ● ●PRKCD RHAG MEIS1 PLA2G4A ● HOXB2 ● SEPP1 ●● VNN1 ● ● ●

● ●● ● ● ●

HOXA4 CCL23 KCNJ2 HOXA10 ● CD300C ADCY2 CD163 HK3 ● FCGR3B CCL1 ● ●ABHD2 ● ● ●EMR1 ●DEFB1 MMP2 CD36 ● ● TNFSF10 TRIM16 CX3CR1 CPVL● ●● ● ● EPB41L3 RASGRP3 C2 ● CD14 C3AR1 ● HOXB6 ● TBXAS1 ● HMOX1 ● AIM2 CLUPPBP ● HNMT CCL20 ● HOXB2 PLS1 ●● ● HOXB3 THBS1 RHAG LGALS2 PF4 ● CD86 ● ● PTAFR ●CAT ● LTBP1 ●MEIS1 PLA2G4A ● COL4A5 ●●● WARS IL1B JAG1 LILRB1 NFKB2 ● ● ARHGAP22 ● CAMK1 ● ● SMPDL3A STS ●LILRA1 ● SPINK2 QPRT PHLDA1 ● CTSL1 ● TYMP ●● ● TRIB1 ● ITGB3 ●●SEPP1 SORT1 ● ● ● SCO2 ● ● IGF2R PTX3 ● ● VNN1 CXCL10 FOXC1 ● ● ● CTSD ● ●C1QB IRX5 ● ● HOXB5 IFI30 ●● ● LILRB3 PRDM2 HOXA5 ●●FGL2 ● ● FPR1 EREG ●PLAUR ● HCK HOMER3 ● SLC16A3 CYP1B1 DMXL2 FTO ●●HIST1H2BC LMNA ● ● ● SMC4 VNN2 ● CCR1 ● CXCL3 ●● MVP PRKAR2B ●RUNX1 MARCKS PBX3 BCL6 ● ● AQP9 ● ABCC4 ● IL6 SERPINB2 ● ● ● ETS2 ●●CXCL2 CTSG NINJ1 ● ●CAST ● ● FBP1 ● LILRB2 ● TCIRG1 FGR ●GCH1 HIP1 ●● G0S2 ●SAT1 ● ●IER3 ● GNS ● ●SOD2 TNFAIP2 LAPTM4B CHST15 ● NAMPT SERPINA1 ● ● ● ● ● NFKBIA ● ● ● HIST1H1C PHKA2 ●● BCL2A1 LGALS3BP ● ●●ACSL1 PRKCD ●FCN1●● ● TNFAIP3 CCL4 PLEK ● CASP1 HIST2H2BE ● ● ●● LILRA3 ● ● ●VCAN ● ●TNF ● ●BASP1 SECTM1 ●●

●

●●●

Pathway: FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN There are 46 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): UBE2D2 Weight Factor: 1.288 Major Gene (NEG): XPO1 Weight Factor: 0.929

NEG ALL Major Gene (NEG): XPO1 Weight Factor: 1.428 Major Gene (BCR/ABL): UBE2D2 Weight Factor: 1.335



DCTN3

SLC35D2

● PFN2 ● KRT10 TGOLN2 TMEM147 MAGED2 ● PSMD8 PPP1R2 ● ● ●PLCL2● ● MRPL40 SOD1 ASMTL ● CBX7 GTF3A NDUFC1 PRPS1 ● ● ●● XBP1 ● ● ● ● DDX1 ● ZMYND11 GLO1CDK14 VPS13B PARP4● JARID2 ● ● ● DDX19A ● ●

●

●

EID1

XPO1 ● PBX3 HNRNPU YWHAQ ● TMX4 ● ● ● ● LYRM1 ATP6V1G1 ● MOAP1 TSPYL4 UBE2D2 HSPA4 ● TMED10 ● ● ● SEP15 ● FKBP1B YY1 MYLK ● ● ● LDOC1 ● ● PFKP ZHX2 ●

●

●

PPP1R2 PFKP

●

●

DDX1 ASMTL MRPL40 ● TMEM147

●

●

DCTN3 PSMD8 ● GTF3A PRPS1 ● PFN2 ● GLO1 ● KRT10 ● MAGED2 ● SOD1 TGOLN2 ● SEP15 PBX3 ● PARP4 HNRNPU ZHX2 ● ● ● ● UBE2D2 ZMYND11 ● ● ● ● VPS13B YWHAQ CBX7 NDUFC1 ● CDK14 ● XPO1 ● ● TSPYL4 ● PLCL2 ● DDX19A HSPA4 ● EID1 ● XBP1 ● ● ● LDOC1 ● ● YY1 JARID2 ● FKBP1B TMED10 ● ● ATP6V1G1 ● SLC35D2 MYLK● ●

●

●

●

MOAP1 TMX4LYRM1

●

●

●

Pathway: CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70 There are 65 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SFI1 Weight Factor: 1.486 Major Gene (NEG): GRIN1 Weight Factor: 1.207

NEG ALL Major Gene (NEG): GRIN1 Weight Factor: 1.337 Major Gene (BCR/ABL): SFI1 Weight Factor: 1.279



TNFRSF1B

● TRIP6AGPS BRF1 BBC3 FGR VCAN ● ● CDK9HPN ● KLRB1 ● MLL4 GAB1 SOCS1 ● HPS1 ● ● GPR56 ● ● ITGA5 ● ● ANXA11 ●● TCF20PCSK7 BAIAP2 GRIN1 IL27RA ●PHC2 OR5I1 DGKA ● ● ● ACOT8 ● CASP8 SPINK1 ● ● EPM2AIP1 ● ● AIP E2F4 ● ZAP70 ● ● ● ●● ACVR2A ● TTN CKMT2● HMGXB3 LRRC15SFI1 IL23A IL32 LCK ● PDE9A● AP3D1 IFT20 CTSW ● ● ● ● ● ● TP53BP1 RRAD● ● CTNND1 ● ● ● PBX3 CRADD ●

●

●

●

●●

CNOT8 RQCD1

●

CTGF ● IGJ SLC2A1 PTPN18 CASP10 XPC STK39 N4BP2L2 ● ● ● FAM134C ● ● ● ● SF3B3 CD200 ● ● ● ● SEMA6A MYBL1 ●

●

OR5I1CTNND1 PHC2 SF3B3 XPC ● ● ●LRRC15 ● IFT20 TRIP6 TP53BP1● ● ● SOCS1 ANXA11 ● RRAD CASP8 ● HMGXB3 BBC3● HPS1 EPM2AIP1 AP3D1 ● ● ● PCSK7 ● AIP ● SPINK1 ● GRIN1 ●CNOT8 ● HPN ● ● ●FAM134CCRADD ● SFI1 TCF20 GAB1 ● E2F4 IL23A ● ● ● MLL4 ● TNFRSF1B ● ● ● ● SLC2A1 ● BAIAP2 ● CASP10 PDE9A ● PBX3 ACOT8 ● CDK9 ● ● ● RQCD1 BRF1STK39 CTGF ● IGJ ● ●ITGA5 IL32CTSW FGR● CD200 ● ● SEMA6A ● CKMT2 ● ● ● ● ACVR2A ● ● ZAP70 ● GPR56 ● AGPS ● DGKA LCK PTPN18

● ●

TTN KLRB1 ●

●

●

MYBL1

IL27RA●

●

N4BP2L2

● VCAN ● ●

●

Pathway: BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS There are 23 genes in this pathway. This pathway was detected by GSCA





●

●

TNFSF10

OAS1

●

●

● TAP1

FPR2

●

●

XAF1

● IFITM3

●

●

● LGALS3BP

●

● IRF7

OASL

●

●

●

OAS2

●

IRF7

● ISG15 IFIT3

●

●

● OASL

FPR2

●

●

●

CAMP

●

●

●

IFI44L IFITM3

CKAP4

STAT1 IFIT3

●

LGALS3BP

CKAP4

●

IFI35

●

PLSCR1

MX1

●

●

AGRN OAS1 MX1

●

●

ISG15 CAMP

●

MX2

TDRD7

OAS2

TDRD7

RNASE2

●

IFI44LMX2

●

●

●

TAP1

●

●

RNASE2

●

PLSCR1

AGRN

TNFSF10

IFI35

●

STAT1

● XAF1 ●

●

Pathway: HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN There are 56 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TYROBP Weight Factor: 1.54 Major Gene (NEG): CFD Weight Factor: 1.341

NEG ALL Major Gene (NEG): CFD Weight Factor: 1.53 Major Gene (BCR/ABL): TYROBP Weight Factor: 1.149



SERPINF1 RNASE6 CRIP1 ● HAL CCR9 SLC2A5 ITGB7 ● ● CSF1R ● RRM2 ● ● ● LGMN NPTX2 ● ● HCK TRIB2MCM4IL6R ● LGALS1 ZWINT ● ● ● ● ● ● ● CFD CST7 CSTA● HGF ARHGEF10 ●TYROBP ●PALLD● LTB IL7R CCR7 ●RAB31 ● ● ● GPR183 ● MS4A3 ● G0S2 CDC20 VCAN ● ● ● S100A8 ● IGJ CEBPD ● ● BLNK AZU1 TRAF4 ● ● ● LEF1 LY86 ● ELANE ● DNTT ● ● SPON1 CTSG PLEK ● CD24 ● IRF8 ● ● ● ● ● F13A1 MME ● CD7 TNF PRTN3 ● ● ● ● ● MPO NRXN2BZRAP1

●

●

●

BZRAP1 ARHGEF10 ● CDC20 PALLD IRF8CTSG ● ● MCM4 ● ELANE

● ● PRTN3 ● ● IL6R ● ● CSTA

CD7

● MPO CFD ● RAB31AZU1 ● TNF ● ● CSF1R ● NPTX2 IL7R ● S100A8TRAF4 ● LGALS1 CCR9 G0S2 ● ● ●PLEK ●● CEBPD ● VCAN NRXN2 DNTT ● CST7 MS4A3 ITGB7 TRIB2 ● ● ● ● ● ● HAL ●HGF TYROBP CRIP1 SPON1 F13A1BLNK ●CCR7 ● ● ● ZWINT ● ●LEF1 ● HCK SLC2A5 ● ●LY86 ● RNASE6 ● ● ● ● RRM2 GPR183 SERPINF1● IGJ MME LGMN ● ● CD24 ● ● ● ●● ● LTB

●

Pathway: RADMACHER_AML_PROGNOSIS There are 66 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IFI27 Weight Factor: 1.572 Major Gene (NEG): SLC6A8 Weight Factor: 1.451

NEG ALL Major Gene (NEG): SLC6A8 Weight Factor: 1.472 Major Gene (BCR/ABL): IFI27 Weight Factor: 0.81



CDC42EP4

● TMEM158 HOXA4 TGM2 ● SELENBP1 ● ● TUBB2A CD3D CNN3IL6ST ● PRG2 ● ● ● HOXB5 UGCG ● TBXAS1 DENND4B HOXB2 ● ● SMG1 ● WDR82S1PR1 TCF4 ● SLC7A7 ● ● ● COL1A1● SFTPB ● FOXO1 PXDN ● DAPK1 ● ● IFI27DMWDFLT3 NFKBIB NFKB1 ●CTNNAL1 ● NFIB ● BAI2 SLC6A8 ● ● AGT ● ● ● ● ●PIK3R4 ●NBL1 SLC2A1 ● MAP7 ● PLIN2 ● GLULFHL2 ● ● PBX3 ● ● MAL ● FGFR1 ● ● EMR1 LCN2 NR2F2 BCL11A SRPX PMP22 PLCG1 ●● ● EZR ● HOXA10 ●● ● ● ● ●

● FARP1

SKAP2 ● TACSTD2 ANGPT1 SEMA3F S100P ● ● ● ● ISG20 ● GUCY1A3 ● TSPAN7ENDOD1 AGRN ● GYPC● ●

●

●

●

FHL2 CNN3 ● SELENBP1 TMEM158 ENDOD1 ●

HOXA10 SKAP2 ● ● ● SLC7A7 AGRNTGM2 ● ● EMR1 TUBB2A IL6ST PMP22 ● ●IFI27 DAPK1 FARP1 ● ● ● ● ● TACSTD2 ● CDC42EP4 PLIN2 ●ISG20 ● ANGPT1 TSPAN7 NFIB PBX3 HOXB2 ● SRPX ● ● ● ● ●EZRFLT3 ● BCL11A ●● PRG2 ● NBL1 ●● GUCY1A3 ● FGFR1 ● ● SLC2A1 GLULTCF4 UGCG ● TBXAS1 ● SLC6A8 ● ● ● COL1A1 PXDN ● MAP7 NFKB1 ● ● CTNNAL1 ● MAL DMWD ● ● S1PR1● ● FOXO1 ●HOXB5 BAI2 ● AGT SMG1 CD3D NR2F2 ● ● GYPC ● ● ● ● ● S100P WDR82 DENND4B SEMA3F PIK3R4 NFKBIB ● ● ● HOXA4 ● PLCG1 LCN2 ● ● ● ● ● ● ● SFTPB

●

Pathway: VERHAAK_AML_WITH_NPM1_MUTATED_DN There are 206 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TFPI Weight Factor: 1.359 Major Gene (NEG): PRODH Weight Factor: 1.286

NEG ALL Major Gene (NEG): PRODH Weight Factor: 1.55 Major Gene (BCR/ABL): TFPI Weight Factor: 0.725



PMAIP1

WASF1 CEACAM4 NCAM1 SCCPDH POLE ●H1F0 TGFB1I1 ● FZD2 MYH11 CLIP3 FAIM3 ●●● RAP2A CD7 RRAGD FGF13 PRAME ●● SMAGP ● MPO YPEL1 TNFRSF21 NBL1 ● PTPRCAP ● MEF2C ● ● ●LRP3 ● ● SERPINF1 PTGIR MSLN ASS1 ● HPGDS ● ● ● CD1C CD200 ● ● DCHS1 BAIAP3 PRODH CHKA ● MEG3 EPS8 ● ● ●SPRY1 ● ● ●● MEF2A ARHGEF12 ● ● KRT1 ● ●● MMP9 ● TCN1ATP9A ●●HPGD ● ●GNAI1 NPR3 CD69 SSBP2 ALAS2GMPR FZD6 IFI16 DACH1 BPGM CD38 GALC ERG ● ●ROBO1 ICAM4 ●B4GALT6 HSPB1 SNCA● TMOD1 ●PRTN3 SPTBN1TACSTD2 HGF ● ●● ●PAM ● ●● FGFR1 SPIB ● ● ARAP2 ● ● GATM TMEM158 ● ● ● ZHX2 LCN2 ● TRIB2 ● ● PRKD3 ● ● ● ● ● PALM ZAP70 PDE4B ● ● ● ● ● THSD7A ELANE ● ● TOX TCF3 FHL1 IL5RA CLEC10A ● ●● GJA1 ● CYP2E1 KIT ● ●NT5E ●LAMC1 BPI● CHI3L1 CACNA2D2 ● BLNK DPYSL2 PPP1R16B ● ● DNTT S100P LTF PXDN ● ● ● ●● F2RL1●●FAM105A TSPAN7 IFI44 ISG20 ● MXRA7 ● ● EZR DHRS3TRAF5 ● ● ●●● PTRFRHOBTB3 RPS6KA2 FCER1A ●SCRN1 MPL ● ● JUP ● ●DLK1 ● ●ALDH2 GSN ● SYNGR1 ● MTMR11 ● TGFBI MECOM ● ● NEDD4 ARHGEF17 ITGA6 ● ● ● CIITA ● ● ●●● MS4A3 CCND2 FOXO1 CCR2 SERPINE2 RBPMS GNG7 RUNX1T1 ● ABLIM1 ● PTGER4 HSPG2 ● ● IFI44L FAM171A1 SPON1 ●EMP1 TFPI● ● TKTL1 ● ● PDE3B ● ITM2A ● ● ●● ● ABCB1 ● CD19 ●● MLLT3 LHFPL2 SERPING1 ●MEST ●● ST18 ●● ●CD48 ●● VEGFA ●MN1 ● ● GPA33 PROM1 GATA3 GPSM2 ● IFITM1 CEACAM6 ● ●HOPX TRBC1 ● ● ● ● ●APP ●● ● POU4F1 ● IGFBP7 MAN1A1 FLNB CD34C2CD2 MDFIC ● ● ● ● MX1 ● CD3D HLA−DPB1 RAMP1 ● ● CAV1 ● ●CST7 HLA−DPA1 ● RUNX3 ● ● ● ● XYLT1 ● ●CSF3R PTPRM ● ADCY3 ● BZRAP1 CD2 GPM6B SPARC PLXND1 RGS1 ● LMO4 AGTPBP1 NRXN2 ● ●HLA−DQA1 ● ● ●● UGCG ● SORL1 ● ● ● TRH ● ● ● GYPC ●● VLDLR ENDOD1 ●● ● P2RX5 OPTN● ● ●●

●● ●

●

●

HLA−DPA1 SPTBN1 HLA−DPB1 MXRA7 ● PDE3B ● PPP1R16B EPS8PAM ● IFI16 TRH PRAME ●OPTN PTPRM HLA−DQA1 ● FAM171A1 ● ● ● EZR ●●SYNGR1 CD2 ● CD69 FGFR1 LHFPL2 BAIAP3 ● ZHX2 ● ● FZD6 VLDLR ITM2A ● ●EMP1 ●ITGA6 ●BLNK PTGER4 MX1 SMAGP SERPING1 IFI44L GATA3 BZRAP1 ● FHL1 VEGFA RGS1 ● ● DNTT TMEM158 HSPG2 ● ● ISG20 ● IFI44 PRKD3 ● TSPAN7 CEACAM6 CSF3R ●CCND2 ● CD48 ●GNAI1 GSN TFPI ● SORL1 ● ● LAMC1 P2RX5 ● ● ● APP ● ● SPARC PLXND1 ● ● ● PDE4B ● ● FLNB NEDD4 ●● ● XYLT1 ●● ●● ● ST18 ● ●IGFBP7 ENDOD1 ● GPSM2 ● IFITM1 ● DPYSL2 ● CD34 DHRS3 ● ● SPIB PMAIP1 BPGM ●● ATP9A ●GMPR ● ●ALDH2 SERPINE2 PROM1 HSPB1 ALAS2 FAIM3 SPRY1 HPGD MEF2A ● ADCY3 SERPINF1 ●SSBP2 KRT1 ●●● CD200 ● GYPC ● GNG7 ● ● ● NCAM1 ● ERG CD38 ● ● ● CST7 TRIB2 ● ● ●●●●GPM6B FZD2CD3D ● ● RUNX3 ●●● ●PTPRCAP ● ZAP70 NT5E ●RAMP1 PALM ● ● ●H1F0 ●TRBC1 MEG3 SNCA ● ● POU4F1 ● RAP2A MEF2C DCHS1 CACNA2D2 TRAF5 TMOD1 MMP9 C2CD2 RRAGD PTGIR ● ● ●● ● GALC ● MYH11FGF13 ● ● ● ● ● ● MAN1A1 AGTPBP1 MPO ASS1 ●S100P CLIP3 HOPX ● POLE MEST ABLIM1 ● PRODH SCCPDH ● PRTN3 CD7 ● ●MDFIC FOXO1 ● ●●RPS6KA2 CLEC10A ● HGF ● ●●CD1C ● ●LMO4 ●●LRP3 CHKA MN1 ● ● ● ● ● ● ● ● TNFRSF21 ●CEACAM4 TOX ●●MSLN ●PXDN ● ● LCN2YPEL1 ● ● NBL1 ● ●WASF1 ELANE ●● ICAM4 UGCG TGFBI F2RL1 SPON1 ● ARAP2 CYP2E1 ● ● ● PTRF NRXN2 SCRN1 ● HPGDS ● ● ● ●● CIITA ● ●●● B4GALT6 ●●ARHGEF17 ● KIT GATM ABCB1 ● ARHGEF12 ● FCER1A ●MLLT3 GJA1 LTF ● ● ●● CCR2 ●RBPMS TGFB1I1 ● TACSTD2 CHI3L1 ● MTMR11 TKTL1 ● MPL IL5RA GPA33 ● ● ●TCF3 ●MS4A3 ● TCN1 RHOBTB3 DACH1 ● ● ● THSD7A ● CAV1 ● ●DLK1 ●●MECOM NPR3 FAM105A ●RUNX1T1 ●● CD19 ● ● ● ● BPI ● ● JUP ● ROBO1 ● ●

●●

●

● ● ●●

Pathway: MUNSHI_MULTIPLE_MYELOMA_UP There are 54 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): DAD1 Weight Factor: 1.418 Major Gene (NEG): PSMB1 Weight Factor: 0.814

NEG ALL Major Gene (NEG): PSMB1 Weight Factor: 1.376 Major Gene (BCR/ABL): DAD1 Weight Factor: 1.095



DDX18 CANXTRIM32 ● XRCC5 ● ● FLT3LG NFKBIA RELB PIM2 FGFR3 CALM2 ● ● ● ● ● MSI1 ● EIF4G2 ● UBC ● CFLAR LIFR ● ● FOXK2 ● ●ACVRL1 HCLS1 JUND MCL1 NACA UBE2L3 CD68 HSPA5 ● CALR

● ●●

●

●

●●

USP9X CYB561D2

●

DAD1 ● USP22 PSME2 ● LY96 ●

KPNA4

●

●

● PAK3 ●

EPOR

●

VAV2 TERT ●

● HSP90B1 CSF1 KRT8 ISG20 PSMA2 ANXA2 ● ABCC3 ● ● ● ● CXCR4SSR4 ● PSMB1 KATNB1 ● HAX1 ZNF91 ● ● ● ● AXL ● RAN ● TMC6 ● ● ANGPT1 IFITM1 ● ●

●

● ●

CFLAR

● EPORLIFR TERT ● ANGPT1 PAK3 ACVRL1 ● ● KPNA4 KATNB1 ● FGFR3 ● ● ● KRT8 ● CSF1 ●VAV2 XRCC5 ● PSMB1AXL LY96 EIF4G2 ● USP9X ● FOXK2 MSI1 ● ● ANXA2 ●ABCC3 ● CXCR4 ● ● ● CD68 PSMA2 ● UBE2L3 ● ● HCLS1 FLT3LG ● SSR4● DAD1●CALM2 NACA USP22 ● ● ● ● ● PSME2 ● CANX● ● CYB561D2 RELB RAN DDX18 ● HAX1 ● TMC6 ZNF91 ● ● ● UBC ● ● TRIM32 ● HSP90B1 ● ● JUND CALR ● ●

●HSPA5 ● ● MCL1 ● PIM2 ● ISG20 ● ● ● IFITM1 NFKBIA

Pathway: FAELT_B_CLL_WITH_VH3_21_DN There are 48 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SPEN Weight Factor: 1.484 Major Gene (NEG): MICB Weight Factor: 1.085

NEG ALL Major Gene (NEG): MICB Weight Factor: 1.461 Major Gene (BCR/ABL): SPEN Weight Factor: 1.332



NDUFC1 PSMD10 ●

TSPOSAP18

●

DDX19A

●

●

● SNW1 PUM1 RABGAP1L ● TBCC ● MKRN1● ● SMC5 ASAH1 ● YWHAB ● TAB2 CDKN1B ● ACBD3 FCGR2B MXI1 ● RNF13 ● HMGN4● MICB ● ● ● ● ● ● ● SPEN ● SMAD2 MOAP1SERP1 ● CTDSP2 PBX3 ASMTL ● CALCOCO2 ● ● ● N4BP2L1 PSMD8 ● IFI6 ● HEBP2 PLCL2 CCNG2 ● ● ● ● RAB31 PLP2 ● ● ● ING1 COX7A2 ● ● LMO4 ● ● SCRN1 ● ADARB1 ● TBL1X NPC2 ● ● ● CTNNA1 POP4 ●DDX1

CBX7

●

TBL1X

● ADARB1NDUFC1 IFI6 ● ● DDX19A PSMD8 TSPO RABGAP1L ● ● ●YWHAB CDKN1B ● ● ● ASAH1 ● PSMD10 DDX1 POP4 RNF13 COX7A2 ● CTDSP2 ● ● LMO4 ●FCGR2B ● CALCOCO2 ● SMAD2 ● SMC5 ● HMGN4 MICB ● RAB31 ● N4BP2L1 ● SAP18 ● ● ASMTL ● PLCL2 ● ● ACBD3 ● SERP1 ● ● TAB2 CTNNA1 ● ● MOAP1 PUM1 SPEN ● PBX3 SNW1 ● ● ● ING1 ● TBCC ● ● CBX7 MKRN1 ● ●CCNG2 SCRN1 ● HEBP2 ● ● ● NPC2 ● MXI1 ● PLP2 ● ●

Pathway: GEISS_RESPONSE_TO_DSRNA_UP There are 30 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TNFAIP6 Weight Factor: 1.378 Major Gene (NEG): BIRC2 Weight Factor: 1.211

NEG ALL Major Gene (NEG): BIRC2 Weight Factor: 1.374 Major Gene (BCR/ABL): TNFAIP6 Weight Factor: 0.878



TNFAIP2PLAUR BNIP3

●

IRF1

●

●

ANXA1

●

●

●

GBP1

● IGFBP6

●

●

●

ATF3

IFIT1 NMI XPO1 ●

NFKBIA

TNFAIP6 ●

●

●

ADAR TFPI2 PSMA3●

●

ELF3

● SUOX ●

FGF2

KLF4

●

●

●

CHN1

CD44

IGFBP6

●

●

●

SUOX

●

ATF3

CHN1

● GCH1

TNFAIP3

● PLAUR

● TNFAIP2 ●

TNFAIP6 TFPI2

●

CFLAR

●

●

●

●

● GBP1

●

IRF1 EIF2S3 ●

XPO1

BIRC2

● ●

●

●

● ADAR ●

IFIT1

●

ELF3 NMI

NFKBIA

●

● ●

●

BTN3A3

GCH1 CFLAR EIF2S3 ● ● TNFAIP3 ● BIRC2

● BTN3A3 CD44 ●

● IQGAP2

BNIP3

●

KLF4

TRAF1

●

IQGAP2

PSMA3

ANXA1

● TRAF1

●

● FGF2

●

Pathway: CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP There are 15 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HOXB5 Weight Factor: 1.246 Major Gene (NEG): TGFB3 Weight Factor: 1.102

NEG ALL Major Gene (NEG): TGFB3 Weight Factor: 1.394 Major Gene (BCR/ABL): HOXB5 Weight Factor: 1.28



CXADR

PIM1

●

●

LEPR

●

UNC5B HOXB5

TNC

HOXB5

●

● ANGPT2

●

●

UNC5B

THBS1

● CD200 ENG

● ADM

●

CXADR

PVRL2

●

●

TGFB3 ● ●

●

PIM1

●

CD200

THBS1 LEPR

PDGFB

TGFB3

●

●

TGFB2

●

●

●

●

●

PDGFB

● ANGPT2

TNC

●

● TGFB2

●

PVRL2

●

ADM

●

ENG

●

Pathway: KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP There are 28 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FGFR4 Weight Factor: 1.381 Major Gene (NEG): FGFR4 Weight Factor: 1.381

NEG ALL Major Gene (NEG): FGFR4 Weight Factor: 1.505 Major Gene (BCR/ABL): FGFR4 Weight Factor: 1.505



HLA−DQA1

CTGF

EIF4E

●

●

CALU

NGF

TPR

RHOD ● FGFR4

● FLOT1

FN1

HGF

●

● RHOB

LCK

TAF1C

●

● BNIP3L ● PRDX4

●

DAXX ● FLOT1

RHOD

●

●

NDRG1

CXCL2

● HLA−DQA1

●

ANXA1

● ●

●

VIM

● TPR

AP3B2 FGFR4

● ●

CTCF IGFBP3 ● NGF●

● LCK

● VIM

CTGF

EIF4E

●

●

●

●

GLRX SOD1

● RHOB

CTCF

NDRG1

● ● ●

CALU

●

IGFBP3 AKAP12

● ●

●

●

SOD1

●

AP3B2

ANXA1

●

●

AKAP12 HGF

●

COL3A1 ● GLRX

●

PRDX4

●

●

●

●

●

●

DAXX

● BNIP3L CXCL2

COL3A1

●

●

FN1

●

TAF1C

●

●

Pathway: COATES_MACROPHAGE_M1_VS_M2_DN There are 44 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): F7 Weight Factor: 1.563 Major Gene (NEG): LBP Weight Factor: 1.394

NEG ALL Major Gene (NEG): LBP Weight Factor: 1.563 Major Gene (BCR/ABL): F7 Weight Factor: 1.545



HSPA1B

RIMBP2

TJP2 ● PROCR ● ●

ANG THBS1 ALDOC ● F10 PRDX2 ● PSMB1 PDXDC1 IGF2R GDF15 ● ● ● MFGE8 F7 ● ● ● ● ● CBLB AHNAK2 ● SLC2A1 ITGB3 RPGRIP1 ● LBP ● ● ARG1 QRICH1 ● ● MGST2 ● XDH ● RIMBP2 CD5L C1QB ● ● CYTIP ● PTGER2 ● ADAM8 FLRT2● ● UCHL1 ● ● ● GPRC5B ● ● CTSK ● LASP1 HSPA1A ● RRAS2 VEGFA ● MYO1F BNIP3 ● ● ● SH2B2 ● ● BST1TLR1 ● CD24 ● ●

●

RRAS2

●

IGF2R CD5L

●

●BST1 ●

QRICH1

●

HSPA1B SH2B2 TJP2 ● UCHL1 ● ●LASP1 XDH ● PSMB1

●

●

● LBP AHNAK2 RPGRIP1 GPRC5B FLRT2 F10 ARG1 ● SLC2A1 C1QB ● ● ● ● ● CD24 ● THBS1 F7● PRDX2 ● GDF15 ●ALDOC ● ● ● PDXDC1 ANG ● PTGER2 HSPA1A ● ITGB3 ● ● BNIP3 ● ● MFGE8 ● ● PROCR VEGFA ● ● CYTIP ● ADAM8 MGST2 MYO1F ● ●

●

●

● TLR1 CBLB ●

●

CTSK

●

Pathway: WALLACE_PROSTATE_CANCER_RACE_UP There are 242 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): RAC2 Weight Factor: 1.409 Major Gene (NEG): POM121L9P Weight Factor: 1.242

NEG ALL Major Gene (NEG): POM121L9P Weight Factor: 1.45 Major Gene (BCR/ABL): RAC2 Weight Factor: 1.123



CCL8 IFNG TRAT1RASGRP3 SELE SLA ● LOC730101 ●CCL4 SLAMF1 CCR7 CREM ●CXCL9 DUSP2 ● ● ●●ADAM28 ● SEPT11 GPR64 GPM6A BCL2A1 GADD45G ●WIPF1 ● CD28 IGKC ● RGS1 ●● CLDN5 ●PDLIM3 RUNX3 CXCL11 ADAMDEC1 SECTM1 ITK PTGDS ● ● CD48 ● ● ● ● GPR183 ● FYNIL1R2 AHNAK2 ● CD2 ● IDO1 CCL5 LY96 FBN1 FCER1G PI15 ● IFIT1 MMP9LAMP3 ● ●CTSS ●SELP ●CLIC2 RAMP3 FGL2 ●NPIPL2 LAPTM5 ●● ● UCP2 GZMK ● ● ●● ● ● ETS2 FYB PDK4 ● ● ● DNASE1L3 FCGR2B CD8A RASGRP1 CEBPD ● NID1 DPYSL4 ● ● CCR5 ● ● ●● ANPEP CLU IL15 ● EDNRA ● HMGCS2 ● ● ● ● GZMA COL21A1 PTPRC NR4A3 ●LILRB2 ● NAT1 IRF8 ● VSIG4 ●PLEK IGHG1 KIAA1462 CDH2 ●CD3D ELOVL2 WNT2B ● ● PTPN22 IRS2 CXCR4 ● ● ● ● ● ● MMP19 OPTN CD86 SCGB1A1 ● IFI16 ● ● PTPN7 IL10RA PLCL1 GPRC5B ● TAP1 SLC7A5 ● ● ● ● IFI27 ISG20 ● ● ● ● ● ● DLC1 ● SERPINB9 MS4A1 RGS16 THBD ●● ●CD1E APOE ●● ● ● CCND1 ● ● ITGA4 RSAD2 HCG26 ● TRBC1 ERAP1 APOL1 ● ● ●● POU2AF1 ●●HLA−F ● PRF1 ●● CCL19 ●IFITM3 WISP1 ● LCP2 ● ● CNN1 IGJ● ● ● CD53 CSF2RB TMX4 FLI1 ● ICAM2 FBN2 ●EVI2A ● ● ● C1QB ● HCLS1 MYBL1 PLEKHO2 ● ● ● ● POM121L9P AMFR ● SRGN NFASC RNASE1 IFITM1 STOM ●IFI6 ●PEX14 ●● ●TMEM158 ● TYMP ● ● ●●●CD27 SEPT6 ● ●DOCK10 ●● ●EVI2B ● ● ● ● ● ● CD83 PRIM2 ARL4C NKG7 HLA−E ● SOCS1 ●P2RY14 SELL ●●GLIPR1 PECAM1 GBP1 NCKAP1L MYB CELF2 GLRX ● ●● ●PDHA1 ADCY7 PLTP MAP4K1 ● SOS1 NFIL3 ●CTNNB1 ARHGAP25 MXRA7 SYT11 IFI44 ●● UBE2L6 ● ● ● ● ● TLE4 ● BTN3A1 TFEC ● ● ●NR4A2 ●ADRA2C ● ●● IFI44L ●●IL16 ● GSTM3 ● GPR171 ●● CPM PIM2 ●CTSC IL2RG ● CDC7 ●APOBEC3G BTN3A2 ● ● ● IFIT3 ● ●ISG15 STK17B IRF1 ● PSMB8 ● HLA−J PSMB9 CD97 ● PSPH ITGAL ●● ●● MX1 CYTIP ● TAP2 ● CD52 HLA−DPB1 ● ●GMFG XAF1 CD37 ●CD93 ●● STAT1 ● CORO1A ●● CHRDL1 ● ●RAC2 ● FAIM3 ●ZAP70 ●● HLA−G OLFML2A GPR65 ● IRF9 SF1 ● ITGB2 ●● ● ● HLA−DQB1 ● ●LCK TRACIGHM MX2 HLA−DQA1 ●HLA−DRA GNG11 ● ● ●GPR18 IL7R ●●● ● ● ● CD69 ●● ALOX5AP ●IFITM2 ●● ● CD1C ● OAS2 ● ● LSP1 ● ● ●● ● ●● RNASE6

●●●● ●

GBP1CD1C EDNRA ISG20 TRAT1 TAP2 HLA−DQB1 TAP1 ● ●MX2 ● RASGRP1 SLC7A5 RSAD2 IFITM3 ● GZMK TRAC CD37 ● IFIT1 ●ICAM2 CD52 PTPN22 IFNG HLA−DRA ● HLA−E TFEC ARHGAP25 ● IFITM2 ● PTPRC CD69 FYN LY96 ● CD27 HLA−DPB1 ● ● MS4A1 ● ●IFI44L ● ● ● IGJ GZMA ● ● CCL5 UCP2 ● ● ● IFI44 CD8A MX1 ●●●●OLFML2A ●SEPT11 IGHM ● ● ● FAIM3 ● IL16 BTN3A2 CD2 GNG11 OAS2 ●● LSP1 ●LCP2 THBD FLI1 ITK ●IL7R ●● ● ● GLIPR1 ISG15 ● CCR7 PECAM1 IFITM1 STOM ● SELL PSMB9 IFI6 ● ● ● ● ● ● ● ●● ● MAP4K1 XAF1IL2RG ZAP70 ● ●CYTIP ●● RASGRP3 UBE2L6 PRF1 LCK PLEKRNASE6 ● SRGN ●APOBEC3G ●● ●ADCY7 CD3D RUNX3 HLA−G ● ●HCLS1 ●FYB ● RAC2 ●PIM2 NCKAP1L IFI16 GPR183 IRF9 MYBL1 ALOX5AP STAT1 IL10RA ●IFIT3 ● CREM ● ● ● NR4A3 IL1R2 TRBC1 ● ● POU2AF1 RGS1 ● CORO1A ● ITGA4 ● SLAMF1 CTSC ● ● ● ● GMFG ● HLA−J ● ● NR4A2 FCER1G ● ● ● IFI27 ● ● ● ● BTN3A1 ● ●●● PLTP NKG7 ITGB2 ● ● CD48 ● IRF1 ● GPR18 PSMB8 GLRX ●EVI2A ● ● ● MYB ● BCL2A1 TMEM158 CD53 ● ● ● HLA−F ● ANPEP ETS2 ● CXCR4 OPTN ITGAL ● SOS1 ● ● ●●●MMP9 CEBPD CD83 CTSS EVI2B ● ●SYT11 ● ● ● PTPN7 IRS2 ●●IL15 HCG26 ● TLE4 GPR65 ● ●SECTM1 ● CSF2RB ● STK17B ●●●TMX4 TYMP ● CLDN5 ● GPM6A GSTM3 ● ●GPR171 ● ●● ● FBN2 ● PTGDS ELOVL2 PEX14 CPM SOCS1 ● ● ●● DLC1 APOL1● PLEKHO2 ARL4C CCL4 DOCK10 ●MMP19 SERPINB9 ● RGS16 ●● ● ● ● HLA−DQA1 NAT1 CD97 ● RNASE1 CDC7 ● ●● APOE IRF8 ●● LOC730101 ●●POM121L9P ● NPIPL2 ●WISP1● ●LAPTM5 ● FGL2 ● ● CCND1 P2RY14 ● NFIL3 ● PRIM2 WIPF1 CELF2 ● ● ● ● RAMP3 PI15 PDHA1 DUSP2 ●MXRA7 LILRB2 SEPT6 CLU ●● PDK4 ● CDH2 ● ●C1QB AHNAK2 ●● SF1● KIAA1462 GPRC5B ●HMGCS2 GPR64 ● ADRA2C ● ●● ●● ADAM28 ● CHRDL1 ● PSPH ● VSIG4 ● ● ●CCL19 ●●● SLA CD93 IGHG1 ● ● ●IGKC ●IDO1 ● GADD45G ●●●● ● ●●DPYSL4 ●●● SELPCTNNB1 ADAMDEC1 CD28 ● SELE● CCL8 LAMP3 CXCL11 ● FBN1 CNN1 CXCL9 ● ●AMFR SCGB1A1 ● CD1E COL21A1 PDLIM3 CCR5 DNASE1L3 ● ● ● ●●CLIC2 FCGR2B ● ERAP1 ● ● ●CD86 ●WNT2B ● ● ● ●●● ● PLCL1 ● NID1 ●● ● ●NFASC

● ●● ●

Pathway: OUILLETTE_CLL_13Q14_DELETION_DN There are 32 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): LPIN1 Weight Factor: 1.454 Major Gene (NEG): RNASEH2B Weight Factor: 0.892

NEG ALL Major Gene (NEG): RNASEH2B Weight Factor: 1.424 Major Gene (BCR/ABL): LPIN1 Weight Factor: 1.232



DUSP6

●

GRK5

MLLT3

●

● DFNA5

GLMN

●

●

KLHL21 ●MAPT ● QDPR ● ● ● LTB4RLPIN1ALDH1B1 CDK2AP1 TRIM13 ● ETV5 ● NDUFA2 ● ● ● ● ●RNASEH2B CYB561 DLEU2 ● GRK5

●

●

DLEU1PHLPP1 PKD2

●

ULK2

●

●

● CASP6 ●

●

AQP3 ●DDAH1 DDR1 ENO2

●

●

●

SERPINE2 BIK ●

●

●

●

●

GFPT2 MYBL2

MYBL2● DLEU1 ●

ETV5

●

CDK2AP1

●

PHLPP1 RNASEH2B ● CDK5R1 GLMN

●

●

●

DUSP6

PKD2

●

●

LPIN1 KLHL21

●

● TRIM13

●

GFPT2

● MLLT3 ● CYB561

●

SERPINE2

●

DDR1 ● NDUFA2

QDPR

DFNA5

CDK5R1

●

DLEU2

●

AQP3

MAPT

● ULK2

●

● LTB4R

ENO2

●

● CASP6

ALDH1B1 ●

●

DDAH1

●

BIK

●

Pathway: FUJII_YBX1_TARGETS_UP There are 22 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NR5A2 Weight Factor: 1.273 Major Gene (NEG): GPER Weight Factor: 1.191

NEG ALL Major Gene (NEG): GPER Weight Factor: 1.413 Major Gene (BCR/ABL): NR5A2 Weight Factor: 0.852



LGALS9

MAOB

●

●

NR5A2

●

CCL5

● CAPG

GPER

●

DIAPH2

SEPP1

●

●

PAM

●

CFB

LGALS9

RARRES3 ●

●

CEACAM1ASCL1

● ACTA2

●

ULK1

●

DIAPH2

MAOB

●

CDKN1A

SLC16A3

●

● FAS

●

●

CAPG

● ●

●

● ●

NR5A2

PAM

CFB CCL5

RARRES3 CDKN1A● ULK1

● ●

●

●

GPER

WARS

●

MVP

FAS

SEPP1

●

●

●

●

●

TRIB2

MX2

●

●

ASCL1

●

MVP

●

MX2

● CEACAM1

WARS

●

SLC16A3

●

●

ACTA2

● TRIB2

●

Pathway: HUANG_FOXA2_TARGETS_UP There are 36 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HPGD Weight Factor: 1.306 Major Gene (NEG): HPGD Weight Factor: 1.306

NEG ALL Major Gene (NEG): HPGD Weight Factor: 1.399 Major Gene (BCR/ABL): HPGD Weight Factor: 1.399



CXCR7

TNFAIP3 ASNS ● TLE4 ● CBLB● MAFF

●

●

RGS2

●

● RELB

● DISC1 C5 ● ● F2R

●

PCK2

SPAG1

●

ACTG2 TOX3

ATP6V0A2 ● ZNF643 ● MAP2 ●

●

● FST

GLUL

● ● JAG1 HPGD

LAMP3 RBPMS

TFPI2 ● ENPP1 CPM ●● ● ● ● EGR4 ●HLCS NRG1 HOMER1 SLC7A11 ● ● ● ● KAT2B ● FN1 SOCS2 ● ● ● TUBB2B

●

CXCR7

●

C5

● ● ● TNFAIP3 TLE4 MAFF ● ● CBLB ● CPM SOCS2 ● ● DISC1 TUBB2B ● HLCS ● TOX3 ● ● PCK2 ● TFPI2 NRG1 ● JAG1 ● ● ZNF643 FST ● SLC7A11 RBPMS ● ● MAP2 F2R ● ● HOMER1 ● ● LAMP3 EGR4 ATP6V0A2 GLUL ● ● ● HPGD RELB ● ● KAT2B ● ● ASNS ● ACTG2 ● ENPP1SPAG1 FN1 ● ● ● ● RGS2

Pathway: SAGIV_CD24_TARGETS_DN There are 34 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CTTN Weight Factor: 1.41 Major Gene (NEG): THBS1 Weight Factor: 0.961

NEG ALL Major Gene (NEG): THBS1 Weight Factor: 1.334 Major Gene (BCR/ABL): CTTN Weight Factor: 0.888



EPHB6

PLAU

● BIK

●

●

FOXD1

CABP1 ● PDGFB

OASL

● ●

●

CST6 OGG1

● PRDX2

● TIMP4

●

●

IL8●

●

●

●

GEM

●

●

ATF3

DUSP5

●

BIK

●

N4BP3

●

● ●

PLAU ECM1

● ICAM1 ● ATF3 ● ● CDKN1A ● N4BP3 LDB1 ADRB2● ● ● TRAFD1 ● PPP1R15A ● ● APOBEC3B HOMER3

●

ECM1 OASL

THBS1

ISG20 PPP1R15A CDKN1A

EMP3 CTTN

●

RELB

●

●

●

●

EMP3

●

●

● CAV1 ● DUSP5

MCAM

●

CTTN ●

●

UROD

GEM HSD17B6 ●

EPHB6

ISG20

PRDX2 ● UROD RELB ●

● IL8

●

TRAFD1

●

MCAMOGG1 ● ●HOMER3 ADRB2 CST6 ● HSD17B6 CAV1 ● ● ● THBS1● APOBEC3B

●

LDB1 ICAM1

●

●

● PDGFB ● TIMP4 ●FOXD1 ●

CABP1

●

●

Pathway: MOSERLE_IFNA_RESPONSE There are 20 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IFI44L Weight Factor: 1.306 Major Gene (NEG): IFIT1 Weight Factor: 1.236

NEG ALL Major Gene (NEG): IFIT1 Weight Factor: 1.297 Major Gene (BCR/ABL): IFI44L Weight Factor: 1.23



TNFSF10

●

IFI44

●

●

CXCL10

STAT1

●

●

IFIH1

IFI16

● OASL

●

●

IFIT2

●

RSAD2

IFIT5

●

IFIT3

●

●

IFIT5

●

●

●

● IFI44L

TNFSF10

●

● GBP1

●

STAT1

●

MX1 IFIT1●

TRIM22

ZC3HAV1

●

IFI44

IFITM1

●

IFIT3

●

IFI16

IFIT1●

●

●

●

●

OAS1

ZC3HAV1

●

IFIH1 IFITM1

●

●

IFIT2

●

OASL

●

IFI44L

OAS2

●

●

● MX1

CXCL10

TRIM22

GBP1

RSAD2

●

OAS1

● OAS2

●

Pathway: BASSO_HAIRY_CELL_LEUKEMIA_DN There are 80 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SDC3 Weight Factor: 1.275 Major Gene (NEG): GABARAPL2 Weight Factor: 0.649

NEG ALL Major Gene (NEG): GABARAPL2 Weight Factor: 1.366 Major Gene (BCR/ABL): SDC3 Weight Factor: 1.316



RAB13 KCTD12

FGFR1● RIN2 ● PLOD2 ● WWTR1 TIMP1 ● ● ADCY9 TRIM2 ● PHF2 IL1R2 ● ME3 MFAP5 IL1R1● RPLP1 SYT1 MAF ● ● S100A13 ● PRSS23 ● ● ● PPIC CAMTA1 ● MTSS1 ● ● CTBP2FLT3 ● CD63● ● ● IL18 NOVA1● FGF2 B2M SUSD5 ● EPB41L2 ● ●RECK ●RCBTB2 PCDH9 SLITRK5 EMP1 ACTB ● ● ● ● PTTG1IP ● THBS1 TIMP4 ● ● IGFBP3 ● ●VAMP3 ● TCF7L2 MAPK10 ● PTGDSSDC3 ● SCN1B ● ● DPYD PLXNC1 ● ● IL3RA DAPK1 MYF6 DST SMPDL3A ● ● ● ● HBB ● TACC1 ● SIX3 ● ● ● ●ANXA1 ● ● ● GAS7PDE4DIP CYB5R1 HPGDS ● ● ●ARAP2 ● MYOF GABARAPL2 RNF11 ● ● ENG ●TMEM59 ●PTPRM ● LILRB2 ARRB2 ● ● TBKBP1 ●TNFRSF1A RRAS ● ● SPRY2 ● ● ●DLC1AIF1 ● CPVL

●

●● ●

●

RTN2 CCND1

● ●

KCTD12 ● ANXA1IL18DSTEMP1 ● ● ● SPRY2● ● SYT1 B2M ● TCF7L2 CD63 PTPRM ARRB2 ● TIMP1● ● IL1R1FGFR1 PDE4DIP ● ● ● ● PLXNC1 MFAP5 ● ● LILRB2 ● MTSS1 VAMP3 ARAP2 ● ADCY9 IL3RA TRIM2 ●DPYD ● ● ●RECK THBS1 IL1R2 TMEM59 ● ● MYF6 ● ● ● MYOF ● ● MAF ● DLC1 ● PRSS23 ● DAPK1 ● GABARAPL2 RRAS SUSD5 ● ● CTBP2 PHF2 ● ● ● RTN2 ● CCND1 ● HPGDS ● RCBTB2 ● ● PTTG1IP TACC1 SIX3 RAB13 CPVL PTGDS TIMP4 ● ●● ● CYB5R1 ● ● ● ● ●PPIC ● RNF11SDC3 FGF2 AIF1 ACTB RPLP1 ● ● ● NOVA1 ● ● PLOD2 SMPDL3A ●IGFBP3 ● ● SLITRK5 CAMTA1 ● RIN2 FLT3 TNFRSF1A ● ME3 ● S100A13 ●MAPK10 ● ENG ● ●● ● ● ● HBB ● ● WWTR1● ● EPB41L2 TBKBP1 ● PCDH9

GAS7

●

SCN1B ●

●

Pathway: BERNARD_PPAPDC1B_TARGETS_UP There are 17 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SNX13 Weight Factor: 1.321 Major Gene (NEG): WBP4 Weight Factor: 0.979

NEG ALL Major Gene (NEG): WBP4 Weight Factor: 1.276 Major Gene (BCR/ABL): SNX13 Weight Factor: 1.145



KLHL9

● TULP3 PENK

●

CNOT2 ANP32A●

COX7C SNX13

●

●

●

HIST1H1C

●

● FAM190B WBP4

●

SCFD1

●

NPEPPS

●

KLHL9

●

●

WBP4

●

ARPC3

MYO7A

●

●

●

SMPD1

●

●

NPEPPS

MYO7A

ENSA

ARPC3

●

COX7C

FAM190B

●

●

ENSA

●

SMPD1

● SNX13

●

TULP3●

HIST1H1C

SCFD1

●

●

● ANP32A CNOT2 ●

●

KYNU

●

PENK

●

KYNU

●

Pathway: BERNARD_PPAPDC1B_TARGETS_DN There are 33 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ADD3 Weight Factor: 1.357 Major Gene (NEG): RARA Weight Factor: 1.177

NEG ALL Major Gene (NEG): RARA Weight Factor: 1.473 Major Gene (BCR/ABL): ADD3 Weight Factor: 1.035



MAPKAPK3 GLDC

RCAN1

● ● GLDC

●

HIP1 ●

AP3M2

STC2

●

STC1 THBS1KIF5C SEL1L3 ● ● ● HDAC4

●

●

PLCE1 PRLR ● SPRED2 ●

FGFR2

CRIM1 ● SERPINA1

●

IL6ST

●

ITGAL ● CRIM1 AP3M2 ADD3 ●

● TMCC1

●

MXI1

● RARA NSF TFF3 ● ● CALM1 ● ● RAP1GAP ● IGFBP5 ● ● SCAMP1 ● HSD17B1 ● ● MAPKAPK3 SH3BP2 ● ITGAL ZMIZ1 ADD3 ● ● MT1X ● ● ● ● HIP1

●

RCAN1 IL6ST ●

●

SH3BP2

●

MXI1

●

MT1X ●

KIF5C●

● SPRED2 ●

HDAC4

PLCE1 HSD17B1 FGFR2

● NSF ZMIZ1

●

●

SEL1L3

●

●

●

●

● RAP1GAP

TFF3THBS1 ● IGFBP5 ● ● RARA TMCC1 ● CALM1 ● SERPINA1

●

●

● STC1

●

STC2

●

SCAMP1 PRLR

●

●

Pathway: BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_DN There are 20 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): SLC4A8 Weight Factor: 1.37 Major Gene (NEG): ACADL Weight Factor: 1.305

NEG ALL Major Gene (NEG): ACADL Weight Factor: 1.325 Major Gene (BCR/ABL): SLC4A8 Weight Factor: 1.001



PDXDC1

ENTPD1

● ●

●

SSPN

PHKA1 TAF4B

●

● ●

●

●

MPZL2

ENTPD1

●

●

TRIP11

●

ACADL EYA1

● TGFBRAP1

ACADL CPT1A

●

PIM1

●

● ● TGFBRAP1

CPT1A

●

●

● PHKA1

●

SSPN

●

●

●

●

●

●

●

CENPC1

ANK3

MPZL2

TRIP11

PDXDC1 KIF5B

●

●

CITED2

CASP9

ACP5

SLC4A8

●

SLC4A8 EYA1

ACP5

●

●

CASP9

●

TNK2

CENPC1

●

●

●

TNK2

KIF5B

PIM1●

ANK3

●

TAF4B

●

CITED2

●

Pathway: HUANG_DASATINIB_RESISTANCE_UP There are 58 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): JAG1 Weight Factor: 1.322 Major Gene (NEG): MET Weight Factor: 1.233

NEG ALL Major Gene (NEG): MET Weight Factor: 1.47 Major Gene (BCR/ABL): JAG1 Weight Factor: 1.219



CALD1 GNG12 ZYX OSMR ● ● ● MSN LYN ELL2 ●

●

● ●

RAI14 MET

IFIT3

●

CAST

TNFRSF21

● EPHB2 RAC2 ● EGFR PCDH7 IL15RA ● ●SNAI2 ● ● NNMT ● ● ● PSMB8● JAG1 ST5 LAMB3 ● UPP1 UBE2E3 PARVA DCBLD2 ● ● FSTL1 AGPS PLAU IFI16 ● ● KCTD12 PSMB9 ● ● ● EXT1 ● SOCS5 CDC42EP3 ● ● TFPI ● ● BTN3A2 ● PTRF ● ● ● ●ANXA1 F3 DPYD ● ● ● ELK3 EPHA2 ● ●AKR1C3 ITGA5 BTN3A3 ● ●TGFBR2 CAST F2RL1 ● TGFBI ● ● ● ●PGM1 DUSP10 ● ARHGAP29 PRNP● INPP1 ●CAV1 ● ●MYO10● ● ● CAV2 ●

●

ELL2UPP1

●

UBE2E3 FSTL1 ● BTN3A2 ●TGFBR2 BTN3A3 ● RAC2 ●

● ●

CDC42EP3 DUSP10NNMT ● EXT1 ● ● ● ● IL15RAITGA5 ● PSMB8 MYO10 ST5 PSMB9 SNAI2 TNFRSF21 ● ● ● PTRF ● ● ● ● RAI14 F2RL1 ● PRNP ● IFI16 METCAV1 ● SOCS5 ● ELK3 ● ● GNG12EGFR ● ● PCDH7 DPYD CALD1 ● ● TGFBI PARVA KCTD12 ● EPHA2 ● ● OSMR ● ● LAMB3 ● ● ● CAV2 ARHGAP29 ● ● JAG1 AKR1C3● EPHB2TFPI PGM1 MSN ● ● ● IFIT3 ● ● ● ● ANXA1 ● DCBLD2 ● AGPS ZYX PLAU● ● LYN● ● ● F3

●

●

INPP1

●

Pathway: TAYLOR_METHYLATED_IN_ACUTE_LYMPHOBLASTIC_LEUKEMIA There are 38 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PROX1 Weight Factor: 1.372 Major Gene (NEG): FOXD2 Weight Factor: 1.071

NEG ALL Major Gene (NEG): FOXD2 Weight Factor: 1.439 Major Gene (BCR/ABL): PROX1 Weight Factor: 1.083



KLHL9

●

CLOCK

KHDRBS3

●

●

AZIN1 STAM

●

RREB1

NOV

●HSF2

● ● NOV TTK ZCCHC11 FOXD2 RFC2 KLHL21 ● ● ● SLIT3 ● EFNA5 PCDHGA12 ZMPSTE24 ● CAV1 ● ● ● SNRPC ● ● RPS14 GRIK2 ● COX5B ARID5B ● ● TOMM70A● PSMA2● ● NFIA FEV ● ● KHDRBS3LAPTM4A ● ● MAML3

NASP

●

●

KCNK2 SUSD5

●

PROX1

●

MYC

●

● ● MCF2L2BCL10 RBBP5 ●GTF2H2 ● ● ●

●

● BCL10

MYC

KCNK2●

●

LAPTM4A KLHL9 ARID5B ● ● STAM ● NFIA● TOMM70A ZMPSTE24 ● ● EFNA5 SLIT3 ● TTK ● ZCCHC11

GTF2H2 ● ● ● ● MCF2L2CAV1 HSF2 ● RREB1 FOXD2 ● RFC2 FEV ● PROX1 ● ● ● ● ● KLHL21 PCDHGA12 ● GRIK2 NASP ● AZIN1 CLOCK ● ● ● COX5B ● RPS14 ● ● PSMA2● RBBP5 MAML3 SNRPC ● ● ● ● SUSD5

●

Pathway: ALONSO_METASTASIS_UP There are 128 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): VBP1 Weight Factor: 1.332 Major Gene (NEG): MDH1 Weight Factor: 1.276

NEG ALL Major Gene (NEG): MDH1 Weight Factor: 1.486 Major Gene (BCR/ABL): VBP1 Weight Factor: 1.445



SERPINA3 ADK ●XRCC5 CDH2 GLO1 IL1RL1 ASH2L CAV1 ●PFKM ● ACADM MMP2 ● ● NDUFB3 MDH1 ● ●ADSL MYB ● ● ● ●CA9SHBIDE CDC5L CBFB NDUFAB1 CKS1B ● LIPA ●● ●PAICS ●CX3CR1 ● ACSL3 SPARC ● AKR7A2 ● KIF11 YWHAQ ● FZD1 ● ● SDHD ● ●CCT5 PMP22 UBE2D2 ● ●●ARID5BMAL ●●SLC25A17 ●EPB41L3 PMM1 ● GGH PPP2CB ●KIAA1279 ● ● ● SCD VBP1 ● GRB2 ● WEE1 ENC1SPA17 RNASE4● SET ●CDYL MFAP1 S100A10 RRAGA ● DCK ● ● TXNRD1 ● ● ● PPP2R5C PRKCA APLP2 CYC1 ● CDKN1A ● ● ●PRKAR1A ● ● HSPA8 ● CXCL12 BZW1 ● SDCBP HMMR ● ● ● ● PPP1R8 ● ● ● ● CGA ● DAD1 TCEB1 PFN1 ● DSG2 ENO1 NCOA4 ALDH1A2 ● TP53I3 ● ●IFITM2 ● ● ● ● STK24 ● GTF2H2 ● NME2 LAPTM4A ● LRPAP1 GSTA4 ●LHFPL2 ● ● ● PDE5A ● RABAC1 TGFBR2● GHITM PPP1R3C ● IGFBP1 ● ● EIF5●●VDAC1 MAPRE1 RPL10A ●● RAN RPS10 TUBB3 ● ● APEX1 ● ● HIST1H4C COX6B1 SEPP1 CASP5● ● PTPRZ1 CD63 ● ● ● ● ● BTF3 ● SMARCA1 ATP6V0D1 KLF10 ● EDNRB ● ● CTSB RAB1A ● ●COX8A ●LUMFGG GABARAP ● GNG12 ● ● ATP6V0B ● ● ITGAV ●●● ●HIST1H3D ●● ●● NPC2 HBXIP CLIC4 ● SRI ● ● ●● EMP1 ● ● FHL1 ● HIST1H4B

●●

●

LHFPL2 ENC1 CYC1 ● ●CD63 PMM1 BTF3 APLP2 GSTA4 PFKM RPS10 ● LRPAP1 PMP22 ● RPL10A ● ● ● ENO1 GRB2 AKR7A2 ● TUBB3 RRAGA ● ● LUM ● PAICS CKS1B ● ●MAL ● ● ●NME2 EPB41L3 ●NDUFB3 SDHD PRKAR1A APEX1 ●ACADM DCK ●● HSPA8 PPP1R8 ● ●ITGAV KIF11 XRCC5 ● CCT5 RAN RABAC1 ● NPC2 ●ARID5B COX6B1 ● ● ● CBFB ● SMARCA1 CX3CR1 ●MYBKIAA1279 PPP2CB ASH2L ● CDKN1A ● ●● ● ● ● ● ●MDH1 ADSL IL1RL1 LIPA ● MFAP1 ●DAD1 ● VBP1 ●ADK ●● SPA17 ● VDAC1 ● SHB ●● CDYL NDUFAB1 ● ● PRKCA SRI ● ● HMMR ALDH1A2 ● ● CGA ● CDH2 PDE5A CA9 ● IGFBP1 ● ●● PPP1R3C ● ● PPP2R5C ● IFITM2 COX8A ● DSG2 HIST1H3D ● ● ● WEE1 RNASE4 ● ● PFN1 ● ● GHITM ● GLO1 EMP1 SCD ● HIST1H4C ● ● ●HIST1H4B ●TXNRD1 IDE● ● ●STK24 FZD1 TCEB1 UBE2D2 MMP2 CAV1 TGFBR2 GGH SDCBP CXCL12 ● ● ● CDC5L ● TP53I3 GNG12 ● ● ATP6V0D1 KLF10 NCOA4 ● ● ● ●●HBXIP ATP6V0B ● ●● ● ● ● SERPINA3 FHL1 ● ● ● ● PTPRZ1 SEPP1 BZW1 EDNRB YWHAQ ● SPARC ●● ● ● CLIC4 FGG● ACSL3 ●● CASP5 GABARAP GTF2H2 ●● ● S100A10● ● ●●MAPRE1 SET EIF5 ● ● ●RAB1A ● ● ● LAPTM4A ● ● SLC25A17 ● ● CTSB

● ●

Pathway: TSAI_RESPONSE_TO_RADIATION_THERAPY There are 29 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TSC22D1 Weight Factor: 1.335 Major Gene (NEG): COL6A2 Weight Factor: 1.279

NEG ALL Major Gene (NEG): COL6A2 Weight Factor: 1.576 Major Gene (BCR/ABL): TSC22D1 Weight Factor: 1.013



TGFBR3

IFIT2 HBB

●

●

●

●

●

SMAD3 VEGFC THBS1 ●

●

●

CD69

●

COL6A3

●

●

●

LGALS3BP TGFBR2

TGFB2

● TNFRSF11B

●

IGFBP5

●

IFITM1

●

●

LIPC

● HBB

●

VEGFA

●

BST2

●

●COL6A1

VEGFC

●

PLAT

●

SERPINE1 IFI6

CYR61 COL4A1

●

CTGF TSC22D1 SERPINE1 ●

●

●

TGFBR3

IFI6

ISG15

●

●

●

●

BST2

●

●

EGR1

●

CFB

● COL6A2

PLAT

●

LGALS3BP

CYR61 ● CTGF

●

●

CD69

●

ISG15

TGFB2

● COL4A1 TNFRSF11B ●

IFITM1

●

LIPC COL6A3 TGFBR2 VEGFA ● IFIT2 ● ● IGFBP5 TSC22D1 ● EGR1 ●

●

●

COL6A2

●

●

COL6A1 ● THBS1

●

●

CFB

●

SMAD3

●

Pathway: DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN There are 21 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): LASP1 Weight Factor: 1.305 Major Gene (NEG): CAP1 Weight Factor: 1.286

NEG ALL Major Gene (NEG): CAP1 Weight Factor: 1.428 Major Gene (BCR/ABL): LASP1 Weight Factor: 1.199



SAT1 TMSB4X

●

● CD27

PPBP

SLC7A7

●

CDK14

● ACTN1

LY96

●

●

VNN2

●

FCER1G

CTSG

●

●

TLR1

CAP1

ACTN1●

●

VCL

●

●

●

GLUL

●

VNN2 SLC7A7

● TMSB4X LY96●

● GLUL

●

●

● ●

FCER1G

● MARCKS

●

PPBP

● CD27

MERTK

TLR1 ADD1

CDK14

●

●

●

LASP1

●

●

LASP1

VCL

ARHGAP1

MERTK DOK1

●

●

●

● ●

● CAP1

SAT1

MARCKS

●

ADD1 ARHGAP1 DOK1

●

●

●

●

CTSG

●

Pathway: FERRARI_RESPONSE_TO_FENRETINIDE_UP There are 16 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CXCL2 Weight Factor: 1.306 Major Gene (NEG): DDIT4 Weight Factor: 0.946

NEG ALL Major Gene (NEG): DDIT4 Weight Factor: 1.334 Major Gene (BCR/ABL): CXCL2 Weight Factor: 1.028



CXCL3

PTGS2

●

SELE

●

SEMA3C

SLC7A5

CCL20

●

●

●

●

CXCL2

●

SELE

●

HERPUD1

CCL20

●

●

CXCL3

●

SLC7A5 DHRS3

DDIT4

●

PTGS2

●

IRF1

● KLF7 NRIP1 ● ATF3 ● ●

BMP2

●

●

SEMA3C

ATF3

CXCL2

●

●

● KLF7

●

DDIT4

●HERPUD1

●

DHRS3

●

●

TRIM33 NRIP1

TRIM33

●

●

● BMP2

●

IRF1

●

Pathway: TOOKER_GEMCITABINE_RESISTANCE_UP There are 64 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): AATF Weight Factor: 1.321 Major Gene (NEG): ASS1 Weight Factor: 0.967

NEG ALL Major Gene (NEG): ASS1 Weight Factor: 1.4 Major Gene (BCR/ABL): AATF Weight Factor: 1.021



TRIM21 FGF9 ● ARFIP2 KIAA0100 XRCC5 ● ● HSPA4 CIAPIN1 ● ● PALLD ODC1 RRM1 ● AIMP2● RRP8 TAF10 ● ● SNRPB ILK ● ACVR1B ● ● TPI1 SLC25A6 ● ● ● TMED3 AATF DHRS7 TMEM5 ATP5O ● ● DSC3 ● ITPA● ARID5B GRHPR ● ● ● ● RPL28 COX8A RNH1 ● ● BAMBI ZNF292 ● ● ABCC2 ● PDE4B ● NAP1L4 ● SP110 PFDN5● ● NUP98 ANXA1 ● CPOX ● ISG15 RPL15 ● PEG10 ● TCF7L2 ● IRF9 ● ● ● ● ● EIF3F ● TRIM22 ● BMP4 ● CIRBP ABHD14A ● TPP1 ● ● IFI6 TOMM34● ● PTDSS1 ● SLC25A3 ● PON2 ● ASS1 BLVRB ● HBE1 MEF2C● ● ● ● CD81 ● LGALS3 ● SAT1 FTH1 ●

●

●●

NUP98 PALLD

● ● RRP8 PFDN5 ACVR1B TAF10 ● RPL28MEF2C FGF9 ● PEG10 TRIM21 ● ● RNH1 ● ● ● DSC3 ZNF292 PON2 ● ● ● ARFIP2 ARID5B ● ● ●ABHD14A EIF3F GRHPRTOMM34BMP4 ABCC2 SNRPB SP110 ● ● ● IFI6 ● TRIM22 COX8A ● ● ● ISG15●TPP1● ● SLC25A6 NAP1L4 RRM1 ASS1 ● ● CIRBP ● ● ● ● ● ●● RPL15SLC25A3 PTDSS1 XRCC5 CPOX ATP5O ● TCF7L2 ● ● ● IRF9 PDE4B ● ● ● ● HBE1 BAMBI ● AIMP2 ● ODC1 BLVRB TPI1 ● DHRS7CIAPIN1 ● ● HSPA4 ● AATF ● LGALS3 CD81 ● ● ILK KIAA0100 ● ● ● ● TMEM5 FTH1 ● ● TMED3 SAT1 ● ● ITPA ● ● ● ANXA1 ● ●

Pathway: TOOKER_RESPONSE_TO_BEXAROTENE_DN There are 64 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): AATF Weight Factor: 1.321 Major Gene (NEG): ASS1 Weight Factor: 0.967

NEG ALL Major Gene (NEG): ASS1 Weight Factor: 1.4 Major Gene (BCR/ABL): AATF Weight Factor: 1.021



TRIM22 SP110●

SAT1FTH1 MEF2C LGALS3

● ●

● TPP1 PTDSS1

● ● ARID5B RNH1 ● ANXA1 TMEM5 ●

●

TMED3●

●

●

HBE1

CD81 SLC25A3 ● BLVRB ● TOMM34● IFI6 ● ● PON2ASS1● CIRBP

● ● ● RRM1AIMP2 ● TPI1GRHPR PDE4B ISG15 EIF3F BMP4 ● ● RPL15 ● ILK●DHRS7 ABHD14A ● AATF ITPA ● ● ● IRF9 ● PALLD PFDN5 ● XRCC5 ● COX8A ●● CIAPIN1 ● ● RRP8 ● TCF7L2 ●KIAA0100 ● RPL28 CPOX ATP5O ●● NAP1L4 BAMBI ● ● ● PEG10 ● FGF9 ACVR1B ODC1 ●NUP98 ● ●● SLC25A6 ● SNRPB ● ZNF292 TRIM21 ARFIP2● ● DSC3 ABCC2 ● ● TAF10 ● ●

●

●

●

●

●

HSPA4

●

NUP98 PALLD ● ● RRP8 ● PFDN5 MEF2C ARID5B FGF9 TAF10 RPL28 RNH1 PEG10 ● ●● ● SP110 PON2 ● TRIM21 ● ● ARFIP2 ● TRIM22 ● ABHD14A ABCC2 ● TOMM34 SNRPB ● IFI6 ● DSC3 ACVR1B ISG15 EIF3F TPP1 ● ●NAP1L4 ●ZNF292 ● ● SLC25A6 ● COX8A ● ● ● GRHPR ● ● BMP4 ● IRF9 ASS1 RRM1 ● ● ● SLC25A3 ●CIRBP ● ● CPOX ● ● RPL15 ATP5O ● PDE4B HSPA4 ● TCF7L2 ● PTDSS1 ●XRCC5 ● AIMP2● ● FTH1 ● CIAPIN1 ● BAMBI ● TMEM5 ANXA1 BLVRB ODC1 ●HBE1 ● SAT1 ● ● LGALS3 ● ●● ● ● DHRS7 ● AATFTPI1 ILK ● ●TMED3 ● ●CD81 ● KIAA0100 ● ITPA ● ● ●

Pathway: ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP There are 86 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMB10 Weight Factor: 1.375 Major Gene (NEG): CCL7 Weight Factor: 1.039

NEG ALL Major Gene (NEG): CCL7 Weight Factor: 1.409 Major Gene (BCR/ABL): PSMB10 Weight Factor: 1.038



MSR1 TAP2

●

KRT18 EIF1AX PROCR C1QB IRF1 FAS ● CXCL10 NR2F6 EIF1 ● ● CCL7 ● ● ● ● MARCO ● SOCS1 LCP2 ● SLC11A1 ● CD53 RNF19B CCL2 NAMPT● ICAM1 UBA7● TAPBP● ●NFKBIA ● ● ● TAP1 ● ● ●AKAP9 CXCL9 ITPK1 ● ●N4BP1 ZIC3 FKBP5 ● IFI35● LBP PTGS1 GBP2LGALS3BP ● COL4A1 ● ●PLD3● PSME2STAT1 ● ● ●CRYAA ● LY86 PSMB9 ● VCAM1 ● PSMB10 TMSB4X ● TFF3 ● ●ATP11A PTPN1 ● CD5L XDH●● LY75 LITAF ● ● ●●CYBA ●● ●PSMB8 ● IL6ST ● ● ●ISG15 ●IFIT1 ● PSME1 MAK16 GBP1 ● TMSB10 ● IRF7 ● ● ● ●● EMR1 ● ● IL18R1 IL1RN ● IFIT3 ● WARS IRF8 MT1G ● CXCL1 ●CTSS ● CD14 HCK ● ● TYROBP ● ● ● MT1F ● AIM1 FGL2 MT1H ●● MT1X CD74 MT1B MT1A ● SAMHD1 ●● MT1E FLOT1 ● ● ●

●

●●

●

FAS FGL2 MAK16 CRYAA SLC11A1 ● ● COL4A1 ● PTPN1 ITPK1 IL1RN ● MSR1 ● EMR1 CXCL10 CTSS ● XDH ● GBP2 ● ● CXCL9 ● ● PTGS1 ● FLOT1 ● IL18R1 ● ● ● LBP ● ZIC3 ● ●FKBP5CXCL1 TYROBP TFF3 ● ● ● ● ● KRT18CCL2 GBP1 ● SOCS1 ● PROCR ATP11A LCP2 AIM1 CD5L ● IRF8 IL6ST LITAF CD14 VCAM1 ● ● HCK ●● ● ● CCL7 ● ● ●● MARCO SAMHD1 EIF1 ● RNF19B ● C1QB ● CD53 ●EIF1AX TAP1 IRF1WARS ● ●NFKBIA● ●MT1B ● ● ●TAP2 TAPBP ● STAT1 ● NAMPT LY86 ● AKAP9 ● MT1X CYBA ● MT1H LY75 ● ISG15 ● ● IFIT1 IFI35 ● ● N4BP1 PLD3 ● TMSB10 MT1FMT1G ● ●● IFIT3MT1E ● IRF7 ● NR2F6 ● ● ● ● ● ● MT1A ●PSME1 LGALS3BP PSMB10 ● ● ● ●ICAM1 PSME2 ● ● PSMB9 ●● ●●● TMSB4X PSMB8 UBA7 ● CD74 ● ●

●

Pathway: LINDSTEDT_DENDRITIC_CELL_MATURATION_D There are 57 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CCR1 Weight Factor: 1.318 Major Gene (NEG): SYPL1 Weight Factor: 1.24

NEG ALL Major Gene (NEG): SYPL1 Weight Factor: 1.502 Major Gene (BCR/ABL): CCR1 Weight Factor: 1.101



FCGRTNPR1

●

●

LST1 NCF2ITGAX ● ACTN1 ITGAM ● ● PTPRE EGR2 ● IGSF6 RAB31 ●AQP3 FGL2 ●CD99 ● ITGA5 ● ● TOP1 ● ● TGFBI DOCK1 CLEC2B ● ● ● MTMR6 F13A1 ● ● RBMS2 ● ARHGDIB ANXA1NCBP2 DAB2 ADCY7 ●

●

● ● ITGB2

●

●

●

● SLC1A5

ATP6V1A CTNND1 NAAA

●

PPAP2B MKNK1 PRSS3 CDH2 ● ● ● ● ● ● SYPL1 ● CLEC10A HLA−DMB P2RY6 ● CCNH ● FCER2 ACP5 LAPTM4A ● HLA−DMA CCR1 ● ● ALOX15 ● MAF ● ● ● RAP1GAP ITGAV ● TPM1 ● ● ● ● RCBTB2 CCL22 ●QSOX1 CIITA

●

● IFI16 DNMT1 ● ● ● ●

●

TPM1 AQP3 ● F13A1MAF ● HLA−DMA ● SLC1A5 ● HLA−DMB EGR2CCNH ITGA5 CTNND1 DOCK1 ●

●

● ● ● ● ● DAB2 ●ACTN1 FGL2 LST1 CD99 TOP1 MKNK1 ● ● ● NCF2 ● ● NPR1 ● IFI16 ● RCBTB2 ● ITGAX NCBP2 ARHGDIB ADCY7 ● ● PTPRE● ANXA1 ● ● IGSF6 ATP6V1A ●ITGB2ITGAM ● NAAA ● ● MTMR6 ● ● SYPL1 ● FCGRT ● ● RBMS2 CIITA ● ● CLEC2B ●ALOX15 CCR1 ●DNMT1 P2RY6 ● FCER2 ● ● CLEC10A ● ● ● ● PRSS3 ● CCL22 QSOX1 RAB31 CDH2 ● ● TGFBI ITGAV ● ● ACP5 ● RAP1GAP ● ● PPAP2B ● ● LAPTM4A ● ●

Pathway: NUTT_GBM_VS_AO_GLIOMA_DN There are 42 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): RPL24 Weight Factor: 1.417 Major Gene (NEG): EIF3E Weight Factor: 1.036

NEG ALL Major Gene (NEG): EIF3E Weight Factor: 1.466 Major Gene (BCR/ABL): RPL24 Weight Factor: 1.37



TNK2

●

ID1 RPL36AL●

● RPL30

RPS20 ● ● RPL23A

EIF3E

●

API5 ● ZMIZ1 ● VDAC2 AFAP1 ● ● PRPF6 ● FLRT1

RPS6 ● UQCRB ● RPS13 RPL24 ● RPL4 KCNK3 ● RPL27A ● ●

●

●

APC2 RBM4B PPIF ● ● PDE8B ● PFKM ABCC8 ● ● AIMP2 ● OLIG2 GRIK2 ● CRY2

RPL9

●

CIRBP EIF3F

●

● ELMO1 PDHX

●

●

● HIP1R TMEM97YIF1A

●

●

●

POLR2F

●

●

NCAM1

●

PRPF6 PDE8B RPL9 ● RPS6 ● ● RPL36AL RPL4 RPS13 ● BCR ● RPL23A●RPL24 ● ● ● RPL30 ● AFAP1EIF3F EIF3ETMEM97 RPL27A● ANGPTL2 ● ● ● ● RPS20 ● VDAC2 KCNK3 ● ● UQCRB PFKM ● ● API5 ● AIMP2 ● ● FLRT1 GRIK2 ● PDHX ZMIZ1HIP1R ● ● POLR2F ● ● ● ELMO1 ABCC8 RBM4B ID1 ●

●

● ANGPTL2

●

●

TNK2

BCR

●

YIF1A CIRBP

●

●

● ● ● CRY2 APC2 ● ● NCAM1 ● ●OLIG2

●

PPIF

●

Pathway: ZHANG_INTERFERON_RESPONSE There are 19 genes in this pathway. This pathway was detected by GSCA





IFITM1 STAT1 ●

IFRD1

●

●

ISG20

● ● IFI30 MX2 OAS2

●

●

● OAS1

●

IFI27

IRF1

●

SP110 IFIT2

●

●

●

IFNB1

MX1

STAT1

●

IFI16

● ●

●

●

OASL

●

IRF3

●

IFITM1

IFI16

ISG15

●

●

●

● MX1 ● IRF3 ● IFRD1

IFI30

ISG20

IRF9

●

ISG15

MX2

●

● OAS1

IRF9

●

OASL

●

●

SP110

●

OAS2 IRF1

●

●

IFIT2

●

IFI27

●

IFNB1

●

Pathway: RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN There are 259 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CNPY3 Weight Factor: 1.397 Major Gene (NEG): TIMP2 Weight Factor: 1.265

NEG ALL Major Gene (NEG): TIMP2 Weight Factor: 1.598 Major Gene (BCR/ABL): CNPY3 Weight Factor: 1.399



DNTTIP2 TCF7L2 PLIN2 HERPUD1 PLCL2 KLF10 ZFP36 ● MCL1 ●HBEGF CD2AP ● STK17A HLA−E ●HEXB ●TLE4 CTSK NR4A2 ●SON ● SLC2A3 LAMP1 ITGAL ATP13A3 RGS2 ● DAB2 TNK2 ● ● SMAD3 ● MAN2A2 NLRP3 ● ● IFITM2 SPTLC2 ● ● ● ● SETD1B PNP NKTR ● ● CTSB ●●MEF2C ● ●NAMPT RERE SYF2 ● CRTAM STK17B ● CTBS RPL22 FPR1 MAPRE2 ZNF384 NEDD9 ●NFATC2IP ● ●KLF9 HNRNPA1 ●NR1H3 CD55 ARFGAP3 SGK1 ●● ● ● ● KLK8 FBXL5 ●●LTB4R GSR ●CNPY3 ITPR1 PINK1 ● IL18 ● ● ●● RPL28 RPS4X ● IL1B ● ● ● CPD ● PLTP ZFAND5 SIK3 STS ● ● TFEB ● CD68 ETS2 ●●● ● ● ● ● ●PRKCB BCAT1● PACSIN2 ● LY86 PLOD3 ●SORL1 PCK2 ● ●●HDDC2 TCIRG1 ● ●ALDH3A2 PDIA5 NCOA1 NUP214 ●SEPT9 AKR1B1 LEPROT TBC1D1 ● ● TMX4 CMKLR1 ● ●CCR1 ● ASAH1 PPIF ●ACAT1 DMXL2 RARRES3 PLSCR1 ●●●●AQP9 ● ● CCRL2 ● ITGA4 ● RASGRP2 SCARB2 MDM1 ● ● ST6GAL1 TIMP2 ● ● ●SLC16A6 ● ● ● ● HK2 PSTPIP1 TSC22D1 ●RHOQ NKG7 SCCPDH CXCL1 ●LILRA2 ENTPD1 CYBB RAP1GAP2 DDIT4 ATP6V0A1 ●EMP1 PDXK ● TUBA4A ● CEBPD ●● EGR1 ANP32A ●● GNS CTSL1 ● CYP27A1 ●● IQGAP2 ● C3AR1 IRAK3 HEBP2 GALC ● ● ● NCOA4 CASP1 ALOX5 LAIR1 ● CCL2 ● ● ● ●MAP4K1 TSPAN3 ●MPRIP ● CCDC69 ● ● ● MYOF ● GTF3A HDAC9 ● ● AIF1 ● PHACTR1 LPXN DECR1 VCAN ITPK1 ● ● VSIG4 ARHGEF6 ●● ●LMO2 FAH CXCL3 ●LILRB2 IFI6● ●GLA ● SLC36A1 CD300A ●● ● ● FCAR DENND3 ● MFHAS1 RIN2 ●●PTGDS IMPA2 ● LGALS3 ● LTA4H CNPY2 SPARC ● CES1 ● ●● TLR1 ● ● GRPEL1 ●CD52 ●ADAM28 ● SDR39U1 ● ● ● ● ACPP RSAD2 MYD88 NOTCH2 ● ICAM2 LILRB4 ● ● LRMP PTGER2 ● SCO2 ● ● IGFBP7 ● HADHA ● ● SNTB1 ● ●●ACADVL ● ● SLC31A1 ● ● CDKN1C ●SLC35B1 STAT1 SELL ● CXCL10 CHST15 ●MX2 ● SP110 ●SUN2 ● ●F2RL1 ACAA2 CTSD OSBPL1A ● ● ● ● ● IDO1 ● APLP2 ● CD14 ● DUSP6 PPM1F ● ● ● FCN1 ●● ● ● FYN PECAM1 CD48 ●●● AOAH SLC7A7 ● SGMS1 ● SH3BP5 OAZ2 ● ●●●CX3CR1 ● ●●● ZNF185 ●● ● NRG1 ● ANXA5 CFP ● ● ZNF804A ●●●●EPB41L3 S100A9 FKBP4 ●●● CCR5 CD163 ABCC3 TM9SF4 ● ● FBP1 S100A12 ●● ●GADD45G AMPD2 ● ● EREG VWA5A ●CFD FYB ● MT1X ●MITF CXCL5 ●● SPOCK1 RNASE4 VNN1 ● ●● ICAM3 CPM ●SLC16A5 ●● SFPQ PLA2G7 ● ● ● ● ● ● FDX1 ● ● HLA−DQA1 ● ● SOD2 ● ● MT1H ● ● ATRX SLC30A1 MT1F ● ● MT2A ● ● ●● ●●MT1G

●●●

●

CXCL10

● ACPP CD163 ALDH3A2 NRG1 C3AR1 TBC1D1 MITF ● CXCL5 HADHA ● SPOCK1 ● SLC16A6 ● CCR5 ● PCK2 ZNF804A ● SFPQIDO1 LAIR1 F2RL1PLA2G7 ● LTA4H AQP9 AKR1B1 VSIG4 ● ●● ● VWA5A RPS4X ABCC3 ● ● ●CD52 ITPK1 FDX1 IFITM2RNASE4 NOTCH2 MFHAS1 RPL22 ● ● GLA ● PLOD3 ● ● HDAC9 ● ● PLCL2 BCAT1 ● GALC HEBP2 ● PTGDS FAH MAPRE2 ● ● ● ● ZNF185 ● MAP4K1 TLE4 ● ITGA4 DECR1 HDDC2 ●CRTAM ● NCOA1 ADAM28 EGR1 SELL ● IL1B ● ● AMPD2 ● SNTB1 ●CTSB ● ANXA5 ● ATP13A3 ● ● FCAR ● ● ANP32A CPM ● FBP1 ARHGEF6 CTSK LAMP1 STS EREG AIF1 SYF2 ● RERE NCOA4 VCAN ● ● HK2 TMX4 ACAT1 HNRNPA1 ● ●TSPAN3 ●●SDR39U1 CCDC69 ●● ASAH1PINK1 ●SGMS1 ● ITPR1 ● ● ●SPARC ● TNK2 ●● ACADVL ●● ●●● FYN ●S100A12 MPRIP SEPT9 ●CD55 ● ● ● FCN1 CMKLR1 ● RAP1GAP2 ATP6V0A1 ●PACSIN2 GRPEL1 ● LPXN ZNF384 PECAM1 CD68 ● DNTTIP2 ● IGFBP7 ● ● NUP214 ● MYD88 ● ●NR1H3 MDM1 ● PPM1F ●● ● ● NFATC2IP LILRB2 IRAK3 ● ● SON ●●IMPA2 DMXL2 ● CPD CD14 HLA−DQA1 PDXK LILRA2 ● CNPY2 SGK1 CASP1 ● ARFGAP3 STK17A ● CD2AP SLC36A1 NKTR ● ● LRMP ● TIMP2 ● ● ● ● CDKN1C ●● DUSP6 ●● ● DAB2 ● PTGER2 CCL2 ● GTF3A PDIA5 MAN2A2 ● ●● CX3CR1 NAMPT ●DENND3 KLK8 ●● ● S100A9 ●● TUBA4A ● ● SCCPDH ● ● SP110 IL18 ● CEBPD CES1 PHACTR1 ● ● ● ● ● GNS TCIRG1 CHST15 ● PLIN2 ● ● ●APLP2 ● ● ● ● ● ●CFD ● ●●ST6GAL1 LY86 SIK3 ●●TM9SF4 PPIF ●● ● ●NEDD9 SMAD3 LEPROT EPB41L3 NLRP3 CNPY3 ● MEF2C IQGAP2 ●●● ●● CYP27A1 ●● RHOQ ● SLC31A1 SETD1B GSR HERPUD1 PSTPIP1 ● CD48 ●MX2 RARRES3 ● ICAM3 ●●PNP ● SH3BP5 TFEB ● ●FPR1 ETS2 TCF7L2 OSBPL1A CCR1 ●● ●●RPL28 LILRB4 ●●●AOAH ●RIN2 GADD45G ● ●SPTLC2 HEXB ● ICAM2 KLF9 ●SORL1 PRKCB ●●ACAA2 CFP ALOX5 RASGRP2 PLSCR1 ● ● ● CTSL1 ●● PLTP ●TLR1 SOD2 ●RSAD2 TSC22D1 ● ● ● SCARB2 ● ● CYBB ● ● ●LTB4R ● ● ●NKG7 SCO2 CTBS ● FKBP4 SLC7A7 ●● ENTPD1 ● HLA−E ● ● ●LGALS3 ● ● LMO2 ●● SLC30A1 ● RGS2 STAT1 CXCL1 ● ● FBXL5 ● ● ZFAND5 CCRL2 ● CXCL3 ● ●EMP1 ● IFI6 CTSD ● STK17B ●● SLC16A5 FYB ● ● ●MT1H ● ● ●● MT1F SLC2A3 ● CD300A ●●NR4A2 MCL1 ●● VNN1 ● ● DDIT4 ● ● ● ● ● SLC35B1 MT2A ● ●ITGAL ● ●● MT1X ● KLF10 OAZ2 MT1G ZFP36 ●HBEGF ● ● ● MYOF ●● ● ●● ● ● ● ATRX ● SUN2 ●

●

●

Pathway: RUTELLA_RESPONSE_TO_HGF_DN There are 187 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CNPY3 Weight Factor: 1.31 Major Gene (NEG): RABGAP1 Weight Factor: 1.21

NEG ALL Major Gene (NEG): RABGAP1 Weight Factor: 1.437 Major Gene (BCR/ABL): CNPY3 Weight Factor: 1.373



RNASE4 RSAD2 FCER1A CX3CR1 FYB ●● S100A12 CDKN1C ● DDIT4 ● S100A9 APLP2 ● ACPP AIF1 AOAH ● NOTCH2 ●CD14 CFD ●SCO2 ●FCN1 ● LILRA2● ● MX2 ● CEBPD CFP SLC7A7 ● MPRIP ●● VCAN PECAM1 ● MAP3K14 ST6GAL1 CASP1 NET1 CD300A LTA4H ●● ● MYD88 ●DENND3 ● ● CD86RPL22 HLA−DQA1 ZDHHC18 SP110 SELL ● TUBA4A AMPD2 ● CD48 ● ● ●● CCDC69 ● TRADD ●● IMPA2 ● LILRB2 HEBP2 ZNF185 IQGAP2 ● STS HNRNPA1 ICAM2 ● ● ITGAL ●● SDR39U1 DUSP6 ● ●ETS2 RAP1GAP2 ●SEPT9 ● ICAM3 DPYSL2 ●RASGRP2 PHACTR1 ● ● SORL1 ● ● CRIP1 SPINT2 LPP● ● CXCR4 PLSCR1 LMO2 ● ITGA4 ● NCOA1 ALOX5 ● ● ARHGEF6 ● IL13RA1 ● ● GRPEL1 FCHSD2GALC HADHA TIA1 ●● IRAK3 ●● ● FCAR ● RUNX3 MAP4K1 ● RPL28●CCNG2 ● LRMP ● FBXL5 ● ● PRKCB ZHX2 ● NEDD9 ●● ● ● ● TROVE2 ●● HDAC9 ● ●● ●● PDIA5 CSNK1E PPM1F ●EGR1 ●TRAF5 SYF2 BTG1 KIAA0922 ● ●TCF7L2MAP4K4 SH3BP5● ● ●● CD52 ● ●NUP214 NFATC2IP ● ANP32A TBCB ● ● ● QPRT GAS6 ACADVL TTN ● ● ●●● TNK2 TMX4CIRBP ● ● ●GADD45B DECR1 ● FNBP1 PTGER2 RARRES3 ● HLA−E SMAD3 GTF3A ● ● PLIN2 ●IFITM2 ●RPS4X ● LTB4R TLE4 RGS2 ● ●● ●KLK8 ● HDDC2 ● CDKN1A NME3 ●NAMPT SETD1B RABGAP1 ● ●●PPP1R16B ●●PTP4A3 ● ●ZNF384 CD55 ● HOMER2 ●LMNB1 MARCKSL1 LY86 HBEGF ● CYTH1 CD83 ● ● ● ● CD163 HERPUD1 ●ITPK1 SMARCC1 SIK3 SFPQ ● IGFBP7 ZFP36 ● CELF2 MAPRE2 ● ● ● ● ● STK17B ● NR4A2 ● ● SLC2A3 ● ● ● ● ●●RERE MED13L ● ● PLCL2 ● ●ADAM19 ● SPOCK1 ● SLC16A5 ●FYN ● ● ● CNPY3 NRG1 FPR1 ● ● MEF2C ● EREGF2RL1 ● ●NLRP3 MCL1 ● ●MAN2A2 ● ● NEK3 ADAM8 ● ● KLF10 ● ZFAND5 ● ● SPTLC2 NKTR● ● ● ● ●ATRX DNTTIP2 ● ● ● ● ●PNP ● ● SON

●

●●

ST6GAL1 PRKCB DDIT4 MYD88 RSAD2 HBEGF LMO2 ZHX2 ● ● ADAM8 HLA−DQA1 ADAM19 MAPRE2 ● RGS2 ZFP36 SLC2A3 ● ● ●● IQGAP2 SP110 ● ●IMPA2 ●PNP MCL1 SH3BP5 PLSCR1 SLC7A7 ● ● ● ICAM2 MX2 CEBPD EREG AMPD2 ●● CDKN1A CCDC69 PECAM1 TRAF5 ● HLA−E IRAK3 ● AIF1 NR4A2 ● ● ● APLP2 ● NME3 ● ITGAL ● HERPUD1 ●TROVE2 HEBP2 ● ● ATRX KLF10 FYB ●CCNG2 STK17B IL13RA1 ● ●● ● NEDD9 ● ● ●● ● LRMP ● ● FNBP1 STS CDKN1C ● VCAN ● ● ●CD83 CD55 ●SYF2 GTF3A NAMPT KIAA0922 MAP4K4 ● ● CD48 ● ● ● CX3CR1 PPM1F CD52 DENND3 ●NLRP3 F2RL1 MAP4K1 ● ● LTA4H ACADVL HNRNPA1 ● ● SLC16A5 ● ●● CYTH1● LMNB1 CD300A ●● CFP SMAD3 SELL ●SFPQ ● ● ● TLE4 ● DNTTIP2 ● ● ● FCN1 IFITM2 GRPEL1 ● ● ● PLIN2 ● ZFAND5 LILRA2 ●● MAN2A2 ●HADHA HDAC9 ● ●ITGA4 TUBA4A ● ●IGFBP7 PPP1R16B ● ●ETS2 SMARCC1 ● ● ● MED13L S100A9 PTGER2 LILRB2 ● ● ● GADD45B HOMER2 CXCR4 CIRBP ● ICAM3 ● RPL22 SPINT2 RAP1GAP2 ● PLCL2MPRIP RARRES3 ● ● ●MARCKSL1 SORL1 ● ●CASP1 HDDC2 ● ALOX5 TRADD RERE TCF7L2 ● ●SON SEPT9 ●BTG1 ZDHHC18 ● ● ● ● ● CRIP1 ● ●● MAP3K14 ● ARHGEF6 DECR1 CFD ● ●TNK2 TIA1● DPYSL2 ● ● ● ●FCER1A ●PTP4A3 ●●PDIA5●●● ● ●● S100A12 ● CELF2 ● ● ● PHACTR1 ● ● CD14 RPS4X ● LY86 ● ● GAS6 ANP32A AOAH FCHSD2 ● ● MEF2C NOTCH2 NET1 NCOA1 ● ● FBXL5 ● RNASE4 SCO2 DUSP6 ●NUP214 ● CD86 TTN ● ● ● SPOCK1 ● RASGRP2 NKTR ● RABGAP1 RUNX3 CNPY3 TMX4 ● ● ● ● KLK8 ● ● ●CSNK1E ● ●● ● ●ITPK1 ● ZNF185 TBCB LPP ●●FPR1 LTB4R NEK3 ● ACPP ●● ● SETD1B NRG1● ● SIK3 ● SDR39U1 EGR1 ● NFATC2IP QPRT ● ● ● ●RPL28 ● ● ●CD163 SPTLC2 ●●● ● ZNF384 FCAR ● ● ● ● GALC ● ● ● FYN

● ●

Pathway: VANTVEER_BREAST_CANCER_BRCA1_DN There are 22 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HDGFRP3 Weight Factor: 1.358 Major Gene (NEG): HSD11B2 Weight Factor: 0.999

NEG ALL Major Gene (NEG): HSD11B2 Weight Factor: 1.354 Major Gene (BCR/ABL): HDGFRP3 Weight Factor: 1.074



ETFB VEZF1

●

●

●

● CSNK1A1

HSD11B2

●

●

RPL23APRKG1 ●

●

●

●

● ●

●

ITGBL1

●

HSD11B2

●

●

VEZF1 ETFB

●

●

ITGBL1

ZFHX3

●

●

DKK3

●

●

●

CTSK

UNC119

●

CTSK

●

●

●

KIAA0100

FMOD

● ● SCAMP1 ●

RPL23A

●

HDGFRP3

BMPR2

●

UNC119 PRKD1

● ZFHX3

DNALI1

●

●

●

CSNK1A1

SCAMP1 ● DNALI1 FMOD

●

CDH11

BMPR2

DKK3

●

CA2 GLI3 ●

HDGFRP3

NQO1

PRKD1

●

●

GLI3

CA2

CDH11

KIAA0100

NQO1 PRKG1

●

●

Pathway: HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_DN There are 21 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MTMR11 Weight Factor: 1.236 Major Gene (NEG): DLEC1 Weight Factor: 1.16

NEG ALL Major Gene (NEG): DLEC1 Weight Factor: 1.419 Major Gene (BCR/ABL): MTMR11 Weight Factor: 1.066



LCP2

●

PRKAA1

NKG7

RHOH

●

●

PCDHB17

●

RGS19

● ● PCDHB17MTMR11 TP63 ● ● ●

● PAGE1

● PPP1R8

●

●

IFNAR1

●

NFE2

PF4

ZNF117

●

●

ZNF117

DYRK2

●

●

PAGE1

●

CXCL12

●

ARFIP1PIK3CG

●

UPK3A

NFE2

●

●

●

DLEC1

●

MNDA

●

● UPK3A

PRKAA1

●

● RGS19

● LCP2

●

TP63

●

IFNAR1

PIK3CG

●

MTMR11

●

●

PF4

●

●

NKG7

●

● ●

CXCL12

DYRK2

●

RHOH ARFIP1

MNDA

DLEC1

PPP1R8

●

Pathway: LEE_RECENT_THYMIC_EMIGRANT There are 87 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): LYPLA1 Weight Factor: 1.376 Major Gene (NEG): HDAC2 Weight Factor: 1.281

NEG ALL Major Gene (NEG): HDAC2 Weight Factor: 1.507 Major Gene (BCR/ABL): LYPLA1 Weight Factor: 1.363



PXDN

●

CD93

● DAPK1 RPS26TNFSF10 HIST1H2BK CSDA HIST1H2AC ● ● GPA33 PRPF19 IGHM ● HIST1H2BD ● ● ● SH2D1A AIF1 CCRL2 ● ● ABCC10 ● CDK2AP1 ● GZMA HEG1 ● ● ●SPRY2 P2RX5 ● TRA2B MICAL2 CEP57 CHI3L2 GPR171 ● ● ●LYPLA1 BCL11A AUH ● FUT8 ● ● ● ● PFDN6NADK ●● ● JUN PLSCR1 ● HPGD ● EGR2 ● ●NINL● HDAC2 ISG15 ● BTBD3 CKS2 PDLIM1 ● ● SPRED2● DSG2 PDCD4 IGF2BP3 TOXCSTF2T ●HTR2B ●CCNG2 ● SMC4 ● FAM3C ● ● ● IFI16● ● ●DARS ● CCR7 ● ● ● ● NR4A2 EEF1E1 ●TCF4 RGS1 ● ● TNFAIP3● ● TOB1 SOX4 AUTS2 CD1BPAICS ●MIF NDUFA7 ● ● CRY1 ● DENND5A ● ●● ● ●TOP2A ● ODZ1 TYMS ● PTGER4 ● ●RNASE6 PSMB2 KIAA0101 TRIO ● ● ●CCR9 ● TAGLN2 ID2 ●PDE4D ● ● MARCKS GATA3 ● PRMT1 YARS ● ● ITM2A ● ●● ● ● ● TKT ● ●

IGHM

●

RNASE6 ●CHI3L2 RGS1

ODZ1 CSDA JUN ● ● HTR2B CD93 ●GZMA TOB1 ● ● TNFAIP3 CCR9CD1B GPR171 TKTNR4A2 ●GPA33 ● PXDN TAGLN2 ● ● ● DSG2 ● ● ● ● YARS ● HEG1 ● TRA2B CCNG2 ● ● ● ● SMC4 PDCD4 LYPLA1 P2RX5 CRY1 ●CKS2 RPS26 ● NINL ● PRMT1 ●● ● ● BTBD3 ● TOX ID2 ● ● ● AIF1 ● NDUFA7 ●HDAC2TYMS ● ●HIST1H2AC MIF PDLIM1 SPRY2 ● HPGD CCRL2 KIAA0101● ● ● FAM3C SOX4● EGR2 ● PSMB2 CSTF2T●NADK ●● ●HIST1H2BK ●EEF1E1TOP2A ● ● FUT8CDK2AP1 ● ● PAICS DENND5A ● ● MARCKS HIST1H2BD IFI16 PFDN6 SPRED2 ●AUH● ● ●CEP57PRPF19 ●AUTS2 ● ITM2A ● ● ● PLSCR1 ● DARS ABCC10 ● ● ● ● TNFSF10 ● ● SH2D1A TCF4 GATA3 ● ● ISG15 ● IGF2BP3 BCL11A ● CCR7 DAPK1 ● TRIO ● ● ● ● ●● ●● ● MICAL2 PDE4D ● PTGER4

●

●

Pathway: SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE There are 86 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): YES1 Weight Factor: 1.445 Major Gene (NEG): PABPC4 Weight Factor: 1.016

NEG ALL Major Gene (NEG): PABPC4 Weight Factor: 1.46 Major Gene (BCR/ABL): YES1 Weight Factor: 0.58



AMPD1 LDHA ● UBE2BCANX GRSF1 ● MYC TM9SF4 PPP2R5C PGK1 ● ● CAV1 ●● XPOT BMI1 ITGA4 ● ● BMP6 ISG20 ● PPP1R2 CYCS ● ●UCK2 HSP90B1 ● VDAC1 PAICS UBE2H ● ● ● ● ●GARS ● ● MPZL1 UAP1 DUSP5● ● CFLAR●SLC37A4 CYP51A1 PIP5K1B GFPT1 MARS ● ●BCKDHA SSR1 ● PAM PDIA4 ● ●●PDK1 NDRG1 ● ● ●● ●● GNG7 NFIL3 ● ● SLC3A2 CCL3 ● PIM2 KRAS ● SUMO1 LDLR NR4A1CD97 GAA ●MXI1 ●ATP5D YES1 ● ● ● ATF4 ● YARS MAN2A1 ●CCPG1 EIF2S2 ● ● DDIT3 ● TNFAIP3 ACP1●TIMP2 ZFP36● ● TRAM1● UBE2J1 ● B3GNT1 ● ● ● ● ● ● ● ● ●SUB1 PRDM1 ● PABPC4 ● ● ATF3 HSPB1 F12● CASP3 HMBS ● ● ● CCNCHSP90AA1 SLC31A1 ● ● HDAC5 ● AHCY ● SORT1 ● ● DNAJB9 ● P4HA1 ● ● ● ● TNFRSF17 BCL2L2 APOBEC3B FHL1 ●

●

●

●●

CD38

●

PPP1R2 TM9SF4 ● APOBEC3B PRDM1 PIP5K1B ● ● ● UAP1 ATP5D PDK1 BMI1 ●P4HA1MARS AMPD1 GRSF1 ● ● HSP90B1 ● SORT1 ●PAICS CYCS GAA TIMP2 ●BMP6 ● ● ● CANX TNFRSF17 ● XPOT ●HSP90AA1 ● CYP51A1 EIF2S2 ● ITGA4 PGK1 ● ● ● ● DNAJB9 DUSP5 ● ● ● ● ● YES1SLC31A1 ● F12 ● ● UBE2H ● LDLR ● SUB1 MYC LDHA SUMO1 ● ● NR4A1 TRAM1 ● MPZL1 ● PABPC4 ISG20 ZFP36 ● ● ● YARS ● ● CCNC UBE2B ● GARS CAV1 CCPG1 UBE2J1 ● NDRG1 HMBS ● ATF3 ● PIM2 MXI1 ● ● ● VDAC1 ATF4 ● ● ● ● ● ●AHCY ● DDIT3 ● ● ACP1 ● SLC3A2 TNFAIP3 CCL3 UCK2 ● ● BCKDHA ●● ● ● ● ● ● HSPB1 ● GFPT1 BCL2L2 KRAS HDAC5 ● SSR1 B3GNT1 GNG7 CASP3 CD38 ● ● CFLAR ●● ● ● ● MAN2A1 SLC37A4 ● PDIA4 ● ● NFIL3 PPP2R5C CD97 ● ●●● PAM ● ● FHL1 ●

●

Pathway: SHAFFER_IRF4_TARGETS_IN_ACTIVATED_DENDRITIC_CELL There are 50 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PAICS Weight Factor: 1.571 Major Gene (NEG): PAICS Weight Factor: 1.571

NEG ALL Major Gene (NEG): PAICS Weight Factor: 1.357 Major Gene (BCR/ABL): PAICS Weight Factor: 1.357



TNFRSF17

UAP1 ISG20

●

● BMI1

IRF4

●

DUSP5

● SUB1SETBP1 ● ● B3GNT1

AURKA ● UBE2J1 ● PIM2 TRAM1 TCERG1 CASP3 CAV1 ● HIVEP2 GLS ● ● ● PRDM1 HMMR ● ● ●TNFAIP3 MYB ● PDIA4 DNAJB9 GFPT1 ● ● ● UCK2 ● DDHD2 ● GNG7 ● PAICS ●CDT1 ● UNG ● ITGB7 ●CANX● WHSC1● ● ● ST6GAL1 ● ● RAB30 GLDC SSR1 FADS1 MNAT1 CD38 ● SEPT11 ● ● ● ● TNFRSF17 ELL2 ● APOBEC3B ● ● E2F5 ● MARS ● ● ATRX FHL1 ● ● HSP90B1 PPP1R2 ● ●

●

●

●

●

FADS1

●

DDHD2 UAP1 UCK2 ISG20 IRF4 ● ● ● DUSP5 CDT1 ● SSR1 ● ● HSP90B1 ●MYB ● ● TNFAIP3 DNAJB9 GLDC ● GFPT1 MNAT1 ● ● ● ● UBE2J1 PIM2 ● PDIA4 ● ELL2 BMI1 ● ● TRAM1 ● SETBP1 ● ● B3GNT1 CANX CD38 SEPT11 TCERG1● SUB1 ATRX ● ● RAB30 ● ● ●● E2F5CASP3● ● UNG ● PAICS ● ● FHL1 ● WHSC1 ST6GAL1 ITGB7 CAV1 ● GNG7

●

● ● GLS ● ● AURKA HMMR ● HIVEP2 ● ● ● MARSPPP1R2APOBEC3B ● PRDM1 ● ● ●

Pathway: FERRANDO_HOX11_NEIGHBORS There are 15 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MTHFD1 Weight Factor: 1.334 Major Gene (NEG): MCM4 Weight Factor: 1.223

NEG ALL Major Gene (NEG): MCM4 Weight Factor: 1.281 Major Gene (BCR/ABL): MTHFD1 Weight Factor: 1.04



PTPRF

TLX1

●

TOP2A CCNA2

●

ERCC1

●

●

●

CD1A

● HPRT1

MTHFD1 CCNA2

RPA1

●

MCM4

● MTHFD1

●

HPRT1

●

●

MAD1L1 CD1B

●

●

●

MCM4

●

TLX1

●

● TOP2A

●

PTPRF

●

MCM5 MCM5

MAD1L1

●

●

RPA1

●

●

ERCC1

●

MME

●

MME

● CD1C

●

CD1B

●

CD1A

●

CD1C

●

Pathway: CROONQUIST_IL6_DEPRIVATION_UP There are 16 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FCGRT Weight Factor: 1.316 Major Gene (NEG): PDE1A Weight Factor: 1.312

NEG ALL Major Gene (NEG): PDE1A Weight Factor: 1.475 Major Gene (BCR/ABL): FCGRT Weight Factor: 0.896



AHNAK

AHNAK

BMP2

●

●

HOMER3

●

● LEFTY2 RAPGEF3

●

PDE1A

FCGRT

●

APOL1

ECM2

●

●

SLC7A7

FCER2

● SCGB2A2

● FCER2

●

●

SCGB2A2 HOMER3

●

●

●

●

RAPGEF3

PDE1A

●

● FCGRT

NCF2 BMP2

●

NCF2

LEFTY2 ARL4C

PCDHGA8

●

●

ECM2

● ●

●

● ●

TBC1D9

APOL1

ARL4C

PCDHGA8

●

●

TBC1D9

●

●

●

●

SLC7A7

Pathway: ZHAN_LATE_DIFFERENTIATION_GENES_UP There are 23 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MCFD2 Weight Factor: 1.311 Major Gene (NEG): MCFD2 Weight Factor: 1.311

NEG ALL Major Gene (NEG): MCFD2 Weight Factor: 1.405 Major Gene (BCR/ABL): MCFD2 Weight Factor: 1.405



DYNLT3 RHEB

●

●

CAV1

FHL1

●

BCL2

RHEB

● ●

●

●

IGF1 BMI1 MCFD2SLC39A6 DUSP5● ● ● ●ARPC1A TSPAN3 ●

PAM

● ARPC1A

HDLBP PAM

ITGA4

● ●

●

BMP6 JAG1

TSPAN3

●

● IGF1

●

SLC39A6

●

●

● AMPD1

MCFD2 BMI1

JAG1

●

BMP6

●

●

●

●FHL1 DYNLT3 ● ●

● PPT1

●

CAV1

EMP3 XK

●

●

CAPN2

●

CAPN2 PPT1

●

●

●

BCL2

ITGA4

DUSP5

●

●

XK

P4HA1

●

AMPD1

●

EMP3

●

●

HDLBP

●

P4HA1● ●

Pathway: ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP There are 30 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TCN2 Weight Factor: 1.215 Major Gene (NEG): TIMP2 Weight Factor: 0.921

NEG ALL Major Gene (NEG): TIMP2 Weight Factor: 1.461 Major Gene (BCR/ABL): TCN2 Weight Factor: 1.263



NUCB2 AMPD3

ITGA6 ● S100A4

●

GPX1

●

●

SEPP1

●

●

TIAM1

●

TIMP2 MARCKS ● TCN2 ●

PRCP BIRC3

●

●

●

●

CXCR4APLP2 FCGRT FUCA1 HSD17B8 TNFAIP3 ● RB1 ● ● ● ● ● NAGLU ●

CXCL12

●

RALY

●

● PPBP

●

PF4

●

DYNLT1

●

SPINT2

●

●

S100A4

● APLP2 TIMP2 B4GALT1 ● ● ● NAGLU

KIAA0513 RALY

●

PRCP

●

●

●

●

NUCB2

●

SPINT2

TCN2 TNFAIP3 MARCKS ●

HSD17B8

●

●

BIRC3

●

●

●

DYNLT1

●

PF4 ●

● FCGRT

IFNGR2

●

● CXCL12

CXCR4 ATP6V1B2

●

SEPP1PPBP

●

●

●

●

TIAM1

● KIAA0513

●

B4GALT1

ATP6V1B2●

● IFNGR2

RB1 AMPD3 FUCA1 ● ITGA6

GPX1

●

Pathway: VALK_AML_CLUSTER_2 There are 25 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): JAG1 Weight Factor: 1.309 Major Gene (NEG): TRIM16 Weight Factor: 0.782

NEG ALL Major Gene (NEG): TRIM16 Weight Factor: 1.334 Major Gene (BCR/ABL): JAG1 Weight Factor: 1.129



HOXA5

IL2RA PDE3B

●

●

●

GUCY1A3

PIM1

●

●

CLU

● JAG1

GRB10

●

●

●

HOXB2

CCL1●

TRPC2

EZR

●

● ARHGAP22

●

MAP4K4 LPIN1

●

●

●

PTP4A3 GLI2

●

●

HBB

●

LAPTM4B

GUCY1A3

●

●

GOLGA8A

TRIM16

●

●

●

●

● DOCK1 ●

MAP4K4 LPIN1

PLS1GPR56

● ●

PIM1 JAG1 LAPTM4BPTP4A3● ● TRPC2 ● ●

HOXA5 PLA2G4A

PDE3B

●

CCL1

●

CLU

●

TRIM16

ARHGAP22 ●

HBB

●

●

● GRB10

GLI2 PLA2G4A

●

EZR ●

●

GOLGA8A GPR56

●

● DOCK1

●

●

HOXB2

●

PLS1 IL2RA

●

●


BCR/ABL ALL Major Gene (BCR/ABL): FZD6 Weight Factor: 1.334 Major Gene (NEG): B4GALT6 Weight Factor: 0.828

NEG ALL Major Gene (NEG): B4GALT6 Weight Factor: 1.256 Major Gene (BCR/ABL): FZD6 Weight Factor: 0.805



CYFIP1

HPGDS RAB13

P2RX5

●

●

●

TSPAN7

CD7

●

B4GALT6

●

LRP10 ABCB1

●

CFD

●

●

FZD6

●

CTNNA1

RAB13

●

CSDA

IL4R

●

ABCB1

●

● ●

B4GALT6

IGFBP7

●

●

●

●

●

HPGDS CTNNA1

● TSPAN7

●

IL4R

CAPN2 CYFIP1

LRP10

●

●

ITGA4

●

P2RX5

● TRAT1

TRAT1

●

●

●

●

●

●

FZD6

IGFBP7

●

TRIB1

CAPN2

●

CSDA

●

CD7

● TRIB1

●

ITGA4 CFD ●

●


BCR/ABL ALL Major Gene (BCR/ABL): ICAM4 Weight Factor: 1.293 Major Gene (NEG): ICAM4 Weight Factor: 1.293

NEG ALL Major Gene (NEG): ICAM4 Weight Factor: 1.515 Major Gene (BCR/ABL): ICAM4 Weight Factor: 1.515



CHI3L1

● MTMR11 ●

RPS6KA2 NT5E

●

●

FAM171A1

CLIP2

●

● PAPSS2

● CBFB

FAM105A

●

PTPRM ST18

●

●

●

CD1C

DHRS3

●

●

CD59 RUNX3

●

●

FCGR2B CBFB

●

NT5E

●

●

● CD81

FAM105A

●

●

CHI3L1

●

RUNX3

●

MN1

●

●

ICAM4

MYH11 ● ● CLIP3

●

MGLL

CLIP2 ● MTMR11 ● PAPSS2

VSIG4

CLEC10A

EMID1

●

ST18

●

●

●

MSLN

● FAM171A1 NRP1

●

●

NRP1EMID1

CD1C

●

MSLN MYH11 CLIP3 MN1 ● ●

●

PTPRM

● ●

●

ICAM4

●

● CD81

●

●

●

CLEC10A

SPARC

CD59

MGLL ● TGFBI SPARCVSIG4 ●

●

●

●

●

FCGR2B

●

DHRS3 RPS6KA2

TGFBI

●

●


BCR/ABL ALL Major Gene (BCR/ABL): ARHGEF17 Weight Factor: 1.27 Major Gene (NEG): SPTBN1 Weight Factor: 1.219

NEG ALL Major Gene (NEG): SPTBN1 Weight Factor: 1.403 Major Gene (BCR/ABL): ARHGEF17 Weight Factor: 1.037



FLNB

C3AR1

●

●

●

● CFD

●

●

RBPMS

●

●

● PIK3C2B EEF1A2 SPON1 ● ●

● RNASE2

●

● TPM2

●

MN1

AZU1

●

●

●

CRIM1 SETBP1 PPP1R16B ● ●

● F2RL1

●

● ●

●

●

CD22

●

BCL7A PRKD2 PPP1R16B

AZU1 LPHN1

C3AR1 SORBS3

FLNB

●

●

PIK3C2B

●

PAWR

CFD

● SNED1

LPHN1

PAWR SPTBN1

TPM2

●

SPRY1

●

●

●

●

●

SNED1

PRKD2

SMAGP ARHGEF17 MLLT3 BCL7A ●

●

GNAI1 EEF1A2

●

IGHM GNAI1 CD22 ●

SPRY1

MN1

CHRDL1

●

●

●

SETBP1

●

●

IGHM

● ARHGEF17SPTBN1 ●

●

RNASE2

● SORBS3

● CRIM1 ● F2RL1SMAGPRBPMS ● CHRDL1 ● ● SPON1 ● ● MLLT3 ●

●

●


BCR/ABL ALL Major Gene (BCR/ABL): THSD7A Weight Factor: 1.271 Major Gene (NEG): ADRA2C Weight Factor: 1.066

NEG ALL Major Gene (NEG): ADRA2C Weight Factor: 1.288 Major Gene (BCR/ABL): THSD7A Weight Factor: 0.967



SLC25A1

TRH

● POU4F1

CAV1 NCALD

LCP1● IL5RA●

CACNA2D2 VLDLR ●

BAIAP3

●

●

ADRA2C

●

● PNMT

●

ADCY7 ITGB4 SLC25A1 ●

●

KDM4B

● VOPP1

●

● GRK5

●

●

●

●

TRH

THSD7A

●

●

POU4F1FBLN5

●

●

FBLN5

NBL1

●

●

ROBO1●

● ●

VLDLR

RUNX1T1

HSPG2

●

ITGB4 BAIAP3 ● ADRA2C ADCY7

●

NBL1

●

PNMTKDM4B

●

PSD3

GRK5

●

LCP1

●

●

VOPP1 CACNA2D2

●

● NCALD

●

●

CAV1

● RUNX1T1

●

●

● ●

ROBO1 THSD7A IL5RA ●

HSPG2

●

PSD3

●

●

Pathway: VALK_AML_WITH_EVI1 There are 22 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): DMXL2 Weight Factor: 1.293 Major Gene (NEG): SPTBN1 Weight Factor: 1.109

NEG ALL Major Gene (NEG): SPTBN1 Weight Factor: 1.359 Major Gene (BCR/ABL): DMXL2 Weight Factor: 0.806



RNASE3

GNAI1

● F2RL1

●

AZU1

●

●

●

●

●

PXDN

●

● IGHM

CFD

LPHN1

●

●

●

●

AZU1

PAWR

CRIM1

GNAI1

● CRIM1

SORBS3 PPP1R16B

●

●

RBPMS

●

DMXL2

●

●

MN1

SMAGP

●

● CD34

●

●

●

PIK3C2B

●

LPHN1

●

● SPRY1

● F2RL1

PXDN

EEF1A2

●

EEF1A2CFD

●

●

SPTBN1

●

CD34

RNASE2

MN1 DMXL2 SORBS3 PPP1R16B

SPRY1

●

●

●

● SPTBN1

RNASE3 RBPMS

●

●

RNASE2

PAWR

●

●

PIK3C2B

SMAGP

●

●

IGHM

●

●

Pathway: JISON_SICKLE_CELL_DISEASE_UP There are 175 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): BLOC1S1 Weight Factor: 1.436 Major Gene (NEG): AZU1 Weight Factor: 0.689

NEG ALL Major Gene (NEG): AZU1 Weight Factor: 1.391 Major Gene (BCR/ABL): BLOC1S1 Weight Factor: 1.256



BLVRA F13A1 TCTA ●ATOX1 GNG5 UBE2L6 GPX1 AKR1A1 ● COX17 PRDX4 LMNB1 ● ● ● VAMP8 PSME2 ● ELANE ● TXN GNG11 ●RRP7A ST3GAL5 LIPA CDKN1A AZU1 PSMB2 ● ● ● NDUFAF3 ● GSTO1 PRDX1 ● GADD45B CLIC4 ● GTF2B ● ANXA3 ●SLC2A3 ATF3 PSMA3 ●CTSG ● ●ATP6V1D ● ● IFI44 ● HTATIP2 PSMB9 RNF24 ● ● ADM NDUFS2 ● ● ● ●● DYNLT1 ● ●TFEC CXCL10 ●DOK1 NFKBIE ● CALR● ● ● ZNF267 ● ● ● PSMB8 RAB13 ● VRK2RHOBTB1 ●CD9 VAMP5 IL15 RIT1 ●CTSA ● CCR2 ● IFIT1 GBP1 ● ● ● PLEK RNASE2 TXNRD1 ●RHEB ● ●GUCY1B3 ● CLIC1 GAS2L1 ● ● BST2 ● GBP2 ● TIMM17A ● ● ● P2RX4 GNPDA1 LHFPL2 ● TUBB2A LAMP2 ● SLC22A4 ● ●● LYL1 STAT1 UBE3C ● CLIC2 UBE2L3 SERPING1 PCK2 ● FCGR1A AXL● RSAD2 ● ATP1B1 IFI30 ●● MX1 ● NOTCH3 PTPRO ●● ●●● ● ● VSIG4 TMED1 ● FN1 HLA−DQB1 ● ● ● ●RSU1IQCE NNAT ●● ● OASL MPP1 BLOC1S1 ●● HLA−A ● ● IFI35 ● ●IGF2BP3 ●●ITGB5 PLIN3 MITF TCN2 ITGA2BIL5RA XK ● SNN ● ● ●● ● ● IFIT2 KYNU ● ● CTSL1 MKNK1 CHP2● ● ● ●●H1F0 NDUFB7 ● CEBPE HBB ●LY6E ● NFE2ITGB3 MARCO ATP6V0A1 PTCRA ●NEK4 TPM1● ● ● ●YWHAH CCRL2IFIT3SPTLC2 ● TRIP6 TYMP ●●BNIP3L BLVRB ● ● ● ● ● SELP PPP2CB PTK2 TIMP1 ● ● ● HMOX1 GM2A EPHB2 NUCB1 ●CALCOCO2 ● ● TAP1 ● ●CPLX2 ● CRADD CDS2 ● ●NAB1 EMP3 ●● MYL9 ● NGFR ●HIST1H2BK SMOX ● ● ● ●P4HB STX7 ● ● ● MPO● MICB ●●ZMPSTE24 ● ● ● ●JAK2 ● WSB2 ●EIF4A3 ●TP53I11 ● SLC36A1 RGL1 RENBP ● CASP7 ABLIM3 ● ● ●● ●● CD151 TDRD7 ●LILRA2●● GADD45A CUL1 ● ● SQLE ●

● ●● ● ●●

CLIC2 CCRL2 GAS2L1 SLC22A4 CTSL1 ANXA3 ● ● HBB ● ● XK ●TPM1 BLVRB ● MITF FCGR1A ● ●NFE2 NNAT ATP1B1 AXL RNASE2 PTCRA BNIP3L GNG11 ●●● NDUFS2 ● ● ●IL5RA ● TIMP1 IGF2BP3 ● RHOBTB1 GNPDA1 ● LHFPL2 TRIP6 CCR2 NOTCH3 ● GUCY1B3 COX17 KYNU ● ● ●VRK2 CHP2 ●● VSIG4 ● IFI30 ● RGL1 ● ● EMP3 ● ● ● ● ● MPP1 GSTO1 CRADD ● ABLIM3 ● ● ● SELP PSMA3 LILRA2 NAB1 PLEK ● ● ● LAMP2 TUBB2A ●PCK2 ATP6V0A1 TIMM17A ● SNN ● ITGA2B ● RSAD2IFI44 ●CEBPE IQCE ● TXN ● NGFR ● CUL1 ● ● ● GNG5 PSMB2 MKNK1 ● ●ZNF267 ● PTPRO ATOX1 ● UBE3C RIT1 TXNRD1 ATP6V1D STX7 CALCOCO2 ●VAMP5 ITGB3 ● ●●●● ● ●HTATIP2 MX1 PPP2CB ● HLA−DQB1 ● SPTLC2 IFIT1 LIPA ●EIF4A3 ● CPLX2 ● TP53I11 ● ● NDUFAF3 ●● JAK2 ●CLIC1 ● ●● ● ● ● ● ITGB5 AKR1A1 ● ● HMOX1 ● GM2A RRP7A ● ● ● CD9 PRDX1 IFIT3 ● TAP1 ● GPX1 OASL TMED1 PRDX4 ● P2RX4 F13A1 ● IL15 CLIC4 VAMP8 IFIT2 ●RHEB PSMB9 LY6E TDRD7 ●GTF2B IFI35 ●DOK1 ●● RSU1 ● ● STAT1 ● ● ● GBP1 ● MARCO ● YWHAH ● CASP7 ● PSME2 PTK2 ●NEK4 ●HLA−A LYL1 ●●CDKN1A CXCL10 UBE2L3 RNF24 SLC2A3 ● ● ● ● ● AZU1 ● ● ● ● ●PSMB8 GADD45B ● GBP2 MICB NDUFB7 ●BLOC1S1 ● ● ● ●UBE2L6 ● ●FN1 CDS2 ●RAB13 H1F0 DYNLT1 ● CTSA ●●TCN2 ● ●TYMP WSB2 NUCB1 HIST1H2BK ● ● ● ● ● ●● ATF3 PLIN3 SMOX LMNB1 ● ●SERPING1 CD151 ● ●●SLC36A1 ADM ●RENBP GADD45A ●MYL9 NFKBIE ●● ● ● ● TCTA EPHB2 BST2 ZMPSTE24 ● ELANE ST3GAL5 ●● ● ● CALR ●● ● BLVRA ● ● ● ●● ● ● ● ●● ● ●MPO SQLETFEC CTSG ● ● P4HB ● ●

●

Pathway: CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN There are 111 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CDK4 Weight Factor: 1.428 Major Gene (NEG): HAT1 Weight Factor: 0.953

NEG ALL Major Gene (NEG): HAT1 Weight Factor: 1.426 Major Gene (BCR/ABL): CDK4 Weight Factor: 1.202



WDR61 STIP1 CAPZA2 ● SEC61A1 COPS3 POLE3 ARPC1A ● ● SYPL1 ● GNB2L1 GNAI1 RHOA ● PDIA6 ● RPS16 PRKAB1 ● ●● CITED2 CTNNAL1 ● ● TM9SF2 ● UQCRFS1 BAX SLC39A6 HBXIP ● ABCB10 ● NUP205 DBI DNAJB9 ATF1 RFC3 SLC25A5 ● SNRPD1 ● ● NEU1 KIAA0196 RCN2 ● ● ● ● ●SNRPD2 ● ●● ●DPM1 ● MAPRE1 GJA1SEC23B RAE1 ● ● PSMA2 ● ●● ATP6V0D1 ● CNN3● MRPS12 COPA ● ● TPD52L1 ● PSMD8 HAT1 ● ● PSMC3 ME2 NUDT21 ● ● SCAMP3 ● ●ALDOA RNASEH2A ● ● RAD51AP1 S100A10 ● RPA3 PRPS1UBE2E3 GLUD2 ●RAN ●LSM2 PCNA TSPAN6 TYROBP ● STOML2 RFC5 SNX2 ● ● ● FCER1G ●● ●DNAJA1 DAD1 ● RFC4 DCTN3 G3BP2 ● ● ● PSMA5 ● ● ● CDK4 PGD IMPA2 ● ● ● CDKN3 ●VAMP3 PIGF PRDX4 FEN1 ● WARSATP1A1 ● CLNS1A SLC29A1 ● ● HSPA8 ● ●E2F5 ●● ● ●CCNB2 ● ● ●● NFYC ● ● ● ATIC ● ●POLE2 ● VDAC3 ●SNX7 C1QBP TYMS ● PGK1 ● CCT4 ILF2 VBP1H2AFZBAG2 ● ●● ●MAD2L1 ● ● CCT2 ● TPX2 ● YAP1 MSH2 ● ● ● ● ● MAGED1 ●● ●● XRCC5 NONO PSMD10

●

●

●

● ADH5

●

RPS16 SNRPD2NUDT21 DCTN3 ● ● ● RAN TPX2 ● HSPA8 SLC29A1 PSMA2 YAP1 STOML2 ● ● POLE2 RFC5 ● ILF2 ● ● C1QBP ●HBXIP CCT2 CNN3 CDKN3 ● ATIC ●● CCNB2 ● RAD51AP1 ● ●VBP1PSMA5 ● ● PGK1 H2AFZ PRDX4 ●●RFC4 ● CDK4CCT4 MAD2L1 NEU1 UQCRFS1● VDAC3 RPA3 ● ● RHOA ● ●FEN1 TYMS ● ● RNASEH2A ● MAPRE1 ● ● HAT1 CTNNAL1 CLNS1A ● PRPS1 ● ● ● ● COPS3NONO RFC3 DBI LSM2 ● MSH2 ●RAE1● POLE3 ● ● ●● ● ●MAGED1 ● ● PGD ●●●ME2PCNA DPM1 TYROBPARPC1A CITED2 DAD1 GNB2L1 ● ● ● SYPL1 ●UBE2E3 SLC25A5 ● ● ● ● IMPA2 CAPZA2 ● SNX2 ● ● NUP205 ● PIGF ● PRKAB1 ● ● GNAI1 DNAJB9 SNX7 ● ●G3BP2 ●DNAJA1 ATF1 ATP6V0D1 ● SNRPD1 ● ● PSMC3 XRCC5 ● ● E2F5 ●RCN2 ● ●ABCB10 PSMD8 ●●TM9SF2 FCER1GSCAMP3 WDR61 ● ●MRPS12 ●BAG2 ADH5 PDIA6 ALDOA ● PSMD10 BAX ● KIAA0196 ● SEC61A1 NFYC ● ● ● ● ● ● TSPAN6 SLC39A6 ● COPA ● ● ● ● STIP1 ● ● ● WARS● VAMP3 GLUD2 ● GJA1 ● ● SEC23B ● S100A10 ● ● ● ATP1A1TPD52L1 ●

●

●

●

●

Pathway: HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_UP There are 53 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MMP14 Weight Factor: 1.345 Major Gene (NEG): SLC8A1 Weight Factor: 1.248

NEG ALL Major Gene (NEG): SLC8A1 Weight Factor: 1.567 Major Gene (BCR/ABL): MMP14 Weight Factor: 1.531



HDAC2 GABRE ● CTSKMSH2 CDH13 ● CLDN7 HSPA1B GPX2 ● ● ● MMP14 SH3YL1 ● SLC8A1 ● GTF2B ● POU2F2 ● ● CD74 TNFAIP3 ●LGALS4 GOLGB1 TACC1 PPP1CB ● ● ● ● ● PLD1AKAP13 ● ● CAP1 ● CLDN10 SLC12A2 OSBPL1A PSMB9 ● ●● MPZL1 ● FRZB TES ● PCNA ● ● ● ● ● UBE2A ● RASGRP1 TCF4 DSC3 ● CYP3A7 ● ●SNAI2 ANXA1 RALY ACTR2 ● ITGBL1 CDH1 ●NKG7 ● ● ● ● LUM ● ● HIST1H2BF ● ● LAMB1 CD48 STAT1 ● ATRX ● ● ●FGL2 CD3D PF4

●

● ● AOAH ● MLL ●

●

FGL2 CD48 LUMCYP3A7 ● PF4● ATRX ANXA1 ● ● ● NKG7 ● ● TES ● DSC3 SNAI2 CLDN10 ● ● CD3D ● AKAP13 ● ● AOAHCDH13 LAMB1 ● CAP1 GPX2 RASGRP1 ● ● POU2F2 PCNA ● ● PPP1CB ● ● UBE2A SLC8A1●MMP14 PLD1 ● TACC1 ● ● TNFAIP3 FRZB HSPA1B LGALS4 ● ●CLDN7 ● GTF2B ● ●

●

●●

● OSBPL1A ● HDAC2 HIST1H2BF CTSK MSH2 PSMB9 ● ● SLC12A2 TCF4 MLL ● ● ●SH3YL1 ● ● RALY ● ● ACTR2 CDH1 ● ● GABRE ● CD74 STAT1 ● ● MPZL1 GOLGB1

●

●

●

ITGBL1

●

●

Pathway: HOSHIDA_LIVER_CANCER_SUBCLASS_S1 There are 228 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ARHGDIB Weight Factor: 1.363 Major Gene (NEG): TIMP2 Weight Factor: 1.236

NEG ALL Major Gene (NEG): TIMP2 Weight Factor: 1.594 Major Gene (BCR/ABL): ARHGDIB Weight Factor: 1.287



PRKD2 ATP6V0B IGKC SMAD2 PLP2 COL3A1 GLIPR1 CYR61 ● POSTN● CD37 ●COL1A2COL5A2 AKT3 CSRP3 ATP6V1B2 COL4A1 SMARCD1 CYP1B1 ● ME1 FLNA ● PPP4C ATP6AP1 NBL1 IKBKE CORO1A ATP6V1F ● COL15A1 ● CDH11 ●●MSN ●●COL11A1 ● PSMD2 ● TCF4 ●●● MGP ● ● PNP ● ●● DNM2 GPNMB ● ● FBN1 ● ADAM8 ●●ALDOA ● ● ● GEM TPM2 ADAM15 LHFPL2 MFAP1 ARHGDIB ● ● LUM EFEMP1 ● PKN1 PPIC IFI16 DAB2 LAMB1 ● DDX11 ACTA2 ● ● IL2RG ● IGLL1 ●● ●LGALS3BP ● AIF1 ●● ● AQP1 ● ●● ● EFNB1 PEA15 ●● ● S100A13 ANXA5 ●● ●STK38 ●FCGR2A GRN PAM LTF ● ● AP2S1 DGKA TRIP10 HLA−DOA ASAH1 ●● ● CTSS PTPRC ● CTSC● CD151 ● LMO4 SLA ● PLD3 ● ● SRI ● ● CD53RALGDS PFN1 GNS ●● QSOX1 DDR1 CYBA CAPZA1 ● GNAI2 LCP1 RCC1 ZNF384 ● ● CXCR4 ● DDR2 MTHFD2 CCND2 ● ● ● ● M6PR ● ● LYN VCAN ● ● TSPAN3 FGL2 IGFBP5 ● ●TNFRSF1B ATP1B3 CDC20 COL4A2 GSTP1 TRAF3 BLVRA ●PGK1 ● ● RPA2 ● ● ITGB2 ●● TUBA4A ITPR3 ● ●● IFI30 CD47 ●SLC2A1 NSMAF ● ● ● LGALS9 ●●● ●ARPC2 RAB31 COL6A2 PROCR OAZ1 ● TAGLN CRABP2 ● LAPTM5 ● ● TMSB4X ● ● ● ARF5 ● ● ● ● ● ● ● CHN1 ●PAK1 PKMYT1 ● TP53BP1 ●● PPP4R1 ●IQGAP1 S100A11 COL6A1 SLC39A6 KLC1 HCLS1 ACP5 CYBB ● ● ● LOX ● SLC1A5 LSP1 ● KLF5 CELF2 ● ● S100A10 ● ANXA1 ● ●NPC2CD48LGALS1 ADAM9 ●● SRGN ● CTGF FYB ●MAP1B ●PYGB ALOX5AP ● TRAF5 ● ●●RIN2 ●● ● ● ● BCL2A1 ● PKD2 ● LGMN TIMP2 ● ● ● ●CD3D ●CXCL1 THY1 LDHB ●● DGKZ ● ● CDC25B ● STX3 ●SLC2A5 ●CBFB SPAG8 IL7R CRIP2 LTBP2 ● ● ●● RNASE6 ●● CD74 CCL5IL2RB RALB ● ● TFF3 ID3 MYCBP2 CYFIP1 ●● RNASE1 C1QB PAPSS1 ● HEXA ●CD8A ●SLC7A5 ●DUSP5 ●KIAA0101 ●● CCL3 ● HIF1A ●● HLA−DMA ● ●● ● MPHOSPH6 FCGBP ● ●●●ANXA4 ● RHOA ● ● ● ● ●DPYSL2 HLA−DQB1 HLA−DPB1 ● CCR7 PLAUR FUT4 DUT ● RSU1 ● LITAF ● ● POLD3 ● PPP1CB ● ● IER3 ●AEBP1 ●● ● DCTN2 PIM2 CDK2AP1 ●● ● ● ● ● GYPC C3AR1 ● ● ● IL15RA RIT1 GUCY1A3 TAX1BP3 ●● ● ● SLBP ●● ● ● ● IRF1 ● F13A1

●● ●

● ●

SLC7A5 RCC1DNM2 AQP1 LYN LAMB1 FBN1 NBL1 ● GYPC TRIP10 ● ● ● DDR2 CD8A ● COL5A2 ARPC2 ● ●ATP6V0B ● PPIC ●COL4A2 CD3D PTPRCPYGB AKT3 TAGLN ●PKMYT1 CCL5 MAP1B ● ● QSOX1 ●GPNMB COL6A1 CXCL1 CRABP2 ● KLF5 IL7R ● FYB ● ACP5 RAB31 ● ● ● LAPTM5 ● ● SPAG8 ● ● ●C1QB FLNA THY1 ●CDC20 LGALS1 GEM PNP PGK1 SMAD2 ●TPM2 C3AR1 ME1 ● PEA15 ●CSRP3 ● DAB2 CYP1B1 ● IL2RB ● COL6A2 ANXA1 ● ● PSMD2 COL15A1 ADAM15 NSMAF ● ● COL11A1 CD151 COL3A1 ● ● ● TP53BP1 ● ● RALGDS ● M6PR PFN1 ● ● CDC25B LUM ● PPP4R1 ● CAPZA1 ● ● MFAP1 FGL2 ● COL1A2 ● BCL2A1 S100A11 ● CCL3 CELF2 LTBP2 ● TSPAN3 ● ●CTSC ATP6V1B2 ● ● ● TIMP2 ● IGFBP5 FUT4 ●HLA−DOA PPP1CB SRGN ●●STK38 ●FCGBP ● ● VCAN ●● LOX ●SLC39A6 POSTN MGP ●● PLAUR HIF1A IER3 ASAH1 ● ● ● CD47 SMARCD1 ● ADAM9 ● MSN ● LMO4 ● ● CRIP2 ● ● ● RPA2 ● ● ●SLC2A1 LSP1 DUSP5 CORO1A ●TCF4 ● DCTN2 RHOA ● ●●COL4A1 ● ●● RIT1 ●AP2S1 ● ● ●IGKC PLD3 IGLL1 ● ●LDHB ● POLD3 ALOX5AP PKD2 ● S100A10 ●TFF3 ITGB2 ●CHN1 IL2RG IFI16 MYCBP2 ● ●● ●● ARF5 ● ●RNASE1 ALDOA ● IKBKE ● CTSS ● ● SLBP DDX11 ● KIAA0101 ARHGDIB ●● CD48 CYBB ● ●● ●●CCR7 ●●● DUT ●●CYBA CXCR4 ● CBFB ●CDK2AP1 ● ● ●●MPHOSPH6 ● TRAF3 ● PPP4C ATP1B3 ● RIN2PLP2 ●● ● ATP6AP1 LCP1 ● NPC2 ● PAPSS1 GLIPR1 ● ● PKN1 ● CYR61 ● ● ATP6V1F ● ● ● KLC1 MTHFD2 ● HLA−DMA ADAM8 ●HLA−DPB1 SLA TAX1BP3 ● DPYSL2 ● GSTP1 ● RSU1 IRF1 ● ● ● CD53 ● FCGR2A IQGAP1 PROCR ● ● ● SLC1A5 ●●TRAF5 IFI30 ● ● RALB ● ● ● PIM2 ● ● EFNB1 ANXA4 LHFPL2 CD37 CD74 LGALS9 ● GNS ●● ●AEBP1HLA−DQB1 ●PRKD2 ● BLVRA ● ● ZNF384 ● EFEMP1 CDH11 ●SRI● HEXA ● ● LTF ●TNFRSF1B GUCY1A3 CYFIP1 ● ● ●HCLS1 ● ● ● ● ● GRN ● ● ●AIF1 GNAI2 ACTA2 S100A13 ● ●●● ●● ● F13A1 ANXA5 ● ● CTGF ● DDR1SLC2A5 ● ● ID3 ● OAZ1 ●● ● STX3 DGKZ ● PAM ● ITPR3 RNASE6 TUBA4A ●● ●CCND2 ●●● ● ● IL15RA LGMN ● DGKA ●● PAK1 LITAF TMSB4X LGALS3BP ●

● ●

● ●●●

Pathway: GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN There are 45 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): APOBEC3G Weight Factor: 1.458 Major Gene (NEG): COL9A2 Weight Factor: 1.135

NEG ALL Major Gene (NEG): COL9A2 Weight Factor: 1.501 Major Gene (BCR/ABL): APOBEC3G Weight Factor: 1.126



PEBP1

●

ID3

●

ABCA6

● DBI

TRAC APOBEC3G LPP

●

●

CDK14

●

LEF1 CELSR1

●SFMBT1 DNMBP LCK FAIM3 ● ● PTPRO● ● ● GBP2 MAP3K5 ● INPP5F ● ● ABR ATXN1 WARS ● ● ● COL9A2 ● FMOD ● CCR7 IGSF3 FILIP1L ●

●

●

●

● ● PTPN22 PBX3 RXRA FCER2 ● VAMP1 ● ● ● SYT17 RAPGEF3SPOCK2 ● COL9A3 TTN ● ● ALDH3A2 ● VASH1 ● ● MARSFRY ● GCLC ● HIVEP2

NEK3

●

● ●

●

ROR1

● KCNN4 ●

●

ALDH3A2 FILIP1L CDK14 MARS ●

●

INPP5F ●

●

SFMBT1 TRAC VAMP1 SYT17 ● ● ● ● ID3 WARS FMODCOL9A2 ● ● ● COL9A3 ● PTPRO ● LEF1 PBX3HIVEP2 FCER2 IGSF3 ● DBI ● ● ● ● ● VASH1 ● ● GCLC SPOCK2 ABR LPP FRY NEK3 ● PTPN22 ● ● ● ● KCNN4 ● ● PEBP1 ● RXRA ● ABCA6 CCR7 ● ● ROR1 LCK TTN ● MAP3K5●

●

GBP2 APOBEC3G CELSR1 ●

●

●

●●

FAIM3DNMBP

● RAPGEF3

●

●

●

ATXN1

●

Pathway: GUTIERREZ_MULTIPLE_MYELOMA_DN There are 29 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): WBSCR22 Weight Factor: 1.36 Major Gene (NEG): WBSCR22 Weight Factor: 1.36

NEG ALL Major Gene (NEG): WBSCR22 Weight Factor: 1.339 Major Gene (BCR/ABL): WBSCR22 Weight Factor: 1.339



SUCLG2

● PTP4A1 YWHAZ ●

●

SEPP1 RHOB

●

COX7C

● SEPT10

● YKT6 WBSCR22 ● ●

MX1

●

● ATP6V0E1

CD47

●

● ●

● RHEB COX7C

●

●

EID1CANX

●

●

BTBD3 ETF1

● ● VDAC2 CNIH TAF9 ● ARF1 ● ● UQCRFS1 ● ● ILF2

●

TAF9

●

VDAC2

PTP4A1 EID1

●

● SRP72 ● ALG8

● RHEB ●

SUCLG2

● CNIH

HNRNPK

●

DCTD

●

BTBD3

●

SRP72 DCTD ●

IFI6

●

VDAC1

●

ALG8

●

HNRNPK

UQCRFS1● CANX ETF1● ●

●

●

YKT6SEPT10

●

● MX1

● IFI6

●

●

VDAC1

●

RHOB

ARF1

ILF2 ATP6V0E1 SEPP1

●

YWHAZ WBSCR22

●

●

●

●

●

CD47

●

Pathway: NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP There are 58 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CSF1R Weight Factor: 1.261 Major Gene (NEG): WISP2 Weight Factor: 1.009

NEG ALL Major Gene (NEG): WISP2 Weight Factor: 1.431 Major Gene (BCR/ABL): CSF1R Weight Factor: 1.194



LY96 VSIG4 IFI44L AIF1IFI30 ● ● CTSCECM1 ● ● ●CSF1R ● ● CD14 SERPINA1 ISG20 ● ITGAM ● TIMP1 HLA−DRA HLA−DQB1 ● ● GZMK MMES100A4 ● CCL5 ● ● ● ● HLA−DPA1 ● ● CD52 ● KYNU TRBC1 GZMA

●

●

● TNFAIP6● DOCK2 ● NCKAP1L THBS1● ● ● HSPA6 F13A1 FCGR2B● SLA C1S ● THBS2 ● CD163CXCL9 ● SERPINE1 ● ● CFH NCF4 IL4RNNMT ●FHL2● PLTP CD44 ● LUM ● ● ● CCL13 ● ● ● ● ● CCL2 ● GPNMB WISP2 CXCL10 PDE4DIP ● APOL1 ● SRPX2 FAP ●● ●● LILRB1 ● ● EFEMP1 C1QB ● ● ITGBL1● ● ●

GZMK

●

CCL5 GZMA NCKAP1L ● ITGBL1 IL4R ● TRBC1

●

● ● ● THBS2 NCF4 SERPINA1 CD14 CD163 GPNMB ●CXCL10 ● ●THBS1 ● CSF1R ● TNFAIP6LILRB1 ● SRPX2 ● CXCL9 ●C1QB ● PLTP HSPA6 ● PDE4DIP ● ● WISP2 CCL13 ● SLA FAP FCGR2B ● CCL2 ● ● ● ● ● DOCK2 ●CTSCCFH ● ● VSIG4● LUM KYNU ● ● APOL1 ● NNMT ● ● ● EFEMP1 ● MME C1S ●HLA−DPA1 ● ● ● CD44 LY96●HLA−DQB1 SERPINE1 CD52 ● ECM1 ●S100A4● ● ●ISG20 HLA−DRA F13A1 FHL2 ● ● ● AIF1 IFI44L ITGAM ● TIMP1 ● ● ● ● ● ●IFI30 ●

Pathway: YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13 There are 103 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): NDUFA2 Weight Factor: 1.527 Major Gene (NEG): PARK7 Weight Factor: 1.402

NEG ALL Major Gene (NEG): PARK7 Weight Factor: 1.403 Major Gene (BCR/ABL): NDUFA2 Weight Factor: 1.393



NDUFA5 ●SEP15 GSTM5 ● ● B9D1 HNRNPL ATP5D NCBP2 ● UQCRC2 EIF4EBP1 C1DRBM3 ● GUK1 ● ● CYB5B ARMCX2ABCC1 RAB28 ● ● CKAP5 ● ● BUD31 ● SUMO3 ATP5F1 GPX4PQBP1 ● NAB1 ● POLD3 ● ● PRDX2 ●MRPL28 ● ● ANXA1 ● ● ● POLE3 ● ● CETN3 ●MRPL23 RELB CYBA CSRP2 ANAPC13SMTN ● PPP2R5C ● IFNGR2 ● NDUFC1 PAFAH1B3 ● ● TAGLN2 ● NACC2 ● ●SNRNP27 REEP5 ● PPIB CALB1 ● ● ●SHFM1 PRPSAP2 S100A10 CAT ● SSNA1 OGFR ● ● ECH1 ● ● HDDC2 RBM14 ● EBP NDUFAB1 PSMA5 ● ● ● ● PPP1R7 ●PSMA6 ● CSRP1 ● ● ● ● TCEB2 FIBP ● PMPCB TKT LGALS1 ● HNRNPH2 ● ● NDUFA2 MTMR9 PEX7 ● ANXA2 H2AFZ ● ATP5J● NEDD8 ILVBL ● PARK7 ●GTF2A2 ● ESD NDUFS2 ● RPP30 ACYP2 ● ● ●CCND1 ● ● ● PCCB PSME2 ● ●●COX7B ● ● ● ● ●FAM3C● PPIH LAGE3 DAP UQCR11 ● TMED3● ● ● NDUFA9 ● ATP5O ● LSM3 ● ●COX5B ●● HBXIP DBI SNRPG ● ● SNRPE DAP3 ● CHMP2A ●SNRPD2 ●

● ● ● ● ● ● NDUFB8 ● UQCRB ● ●

DAP ATP5D B9D1 ANXA1 TMED3 ● EIF4EBP1 POLE3 ● ● SUMO3 ANXA2 ● TAGLN2 ● NACC2 ● ●●C1D LGALS1 S100A10 RPP30 NDUFA5● ● NCBP2 SNRNP27 ● RBM3 TKT CYB5B ● ● ● ● ● ESD ● ●IFNGR2 PPP2R5C● PPIB MRPL23 ● ● OGFR ATP5F1 ABCC1● ● RELB ● H2AFZ MRPL28 CSRP1 HNRNPH2 ● ● ILVBL GSTM5 RBM14 CYBA ● HBXIP UQCRC2 FIBP ● ECH1 ● RAB28 ● ●● ● ● ●●●● PAFAH1B3 BUD31 ●SSNA1 FAM3C ● ●NDUFA9 ●PSME2 PMPCB NAB1 ● NEDD8 ARMCX2 ● PSMA6 PPP1R7 CSRP2 PQBP1 ● SMTN ●REEP5 GUK1 ●● ● ● ● ● ● ● LAGE3 ●● EBP ● SHFM1 ● NDUFB8 ●MTMR9 ●CCND1 HNRNPL CHMP2A ATP5J ● ● ATP5O GPX4 ● NDUFA2 TCEB2 ● CAT UQCR11 ● ● ● CALB1 HDDC2 ● SNRPD2 ● POLD3 ● UQCRB ●PARK7 ● LSM3 PPIH ● ● NDUFAB1 GTF2A2 ● ● ● SNRPE● ● SNRPG ● NDUFC1 ● CKAP5 COX7B ●PRDX2 ●COX5B ● PRPSAP2 ● ANAPC13 DAP3 ● ● ● ● DBI ● ● PSMA5 NDUFS2 ● ● ● PCCB CETN3 SEP15 ● ● ACYP2 ●

●

●● ●

PEX7

●

●

Pathway: SASSON_RESPONSE_TO_FORSKOLIN_UP There are 68 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PSMC3 Weight Factor: 1.355 Major Gene (NEG): GNAS Weight Factor: 1.152

NEG ALL Major Gene (NEG): GNAS Weight Factor: 1.481 Major Gene (BCR/ABL): PSMC3 Weight Factor: 1.053



MAP2K1 GNLY● FKBP5 CDC42EP4 ACPP TUBB2A EZR ● ● ● ● ● CYP19A1 ● GDE1 PRKAR1ACASP9 STAR GPRC5B PPFIA4 ● ● ● ACP2● GPR56 CYP11A1 ● PTPRN ● BNIP3L HSD11B1 ● COL18A1 ● ●ALPL ● PTPN21 FDXR ● DUSP9 SMARCA4 ● ARPC1A ●NOL3 ● ● ● ● RAB2A LHCGR ● MAP3K7 HSD3B1 CHUK ● ● PSMD1 ● ITPR1 ● GNAS ● ● ● ●PHKA2 BAG1 COL15A1 ● PPP2R5B HSD3B2 ● ● ● PGK1 ● DUSP1 ● ● BAD PLIN3 TLN1 ● CREBL2 PSMC3 ● MBD2 ● ● ● RAB4A ● SGK1 PPAP2A

● ● ● ●PRKX GRK5 PPP2R1A RAB27A ● CFLAR CD55 MAPK14 ● ● ● ● ● ● ATP2B1 PDXK RAB1A UPP1 ARHGEF5 ● MAP3K5 TMBIM6 ● ●P4HA2 ● ● ● ● ● ● GK ●

●

STAR CDC42EP4 ● FKBP5 PPP2R5B PRKAR1A MAP2K1 ● ● ● RAB2A ● PPAP2A SGK1 ● CREBL2 ITPR1 ● TLN1 ● CASP9 ● PRKX PTPN21 ARPC1A ●DUSP1MAP3K7 ● COL18A1 ● ● RAB4A ● EZR ● ● ● PTPRN ● ●GNAS ● ● FDXRMBD2 NOL3PSMD1 BAG1 BAD ● ● ● ● DUSP9 ALPL ● ●● TMBIM6 ●GDE1 ACP2 CYP11A1 MAPK14PPP2R1A ● SMARCA4 PGK1 BNIP3L ● ● ● ● PHKA2HSD3B1 ● ARHGEF5 ● ● CHUK ● GK ● TUBB2A ● ● ● CD55 ● ● ● P4HA2 CYP19A1 ● PSMC3 UPP1RAB1A ● ACPP MAP3K5 PLIN3 ● ● ●LHCGR● ● ●GRK5 ●GPR56GPRC5B ● ●ATP2B1● CFLARCOL15A1

●

● ● ● HSD3B2 GNLY RAB27A PDXK PPFIA4 HSD11B1 ● ● ● ●

●

●

●

Pathway: RAGHAVACHARI_PLATELET_SPECIFIC_GENES There are 63 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ITGA2B Weight Factor: 1.319 Major Gene (NEG): GNAS Weight Factor: 1.175

NEG ALL Major Gene (NEG): GNAS Weight Factor: 1.541 Major Gene (BCR/ABL): ITGA2B Weight Factor: 0.934



NAP1L1

SNN

●

● HBB PDLIM1 ● TUBB2A CCL5 ● SNCA

PRDX6

SPARC● RABGAP1L

●

●

MLH3 ● ASAH1 ZNF185 PRKAR2B APP ●

●

● PF4 NRGN ITGB3 RGS10 ITGA2B ● ● ● ● ● WIPF1 ODC1VCL PIP4K2A ITGB5 ● RAB31 ● ● ● PPBP PGRMC1 ● ● ● ●ENDOD1 ● ● GLA ● MYLK TNFSF4KIF2A TPM1 ● GNG11 ● ● ● RSU1 ● PRKCB ● ● F13A1 CTSA CTTN ● MFAP3L PF4V1 ● ● ● ● ● PTGS1 HIST1H2BK TAX1BP3 ● ● HIST2H2BE TUBA4A ● GNAS TSC22D1 CXCL5 MAX ● ● HIST1H2AC ● ● ● ● ● ● FHL1 EIF2AK1 LEPROT PRUNE ● ● MPP1 PTPN12 RNF11 ● ● ● ● ● RYBP ● ●PPM1A MMD ● ● THBS1 ●

NAP1L1

●

RSU1 HIST1H2BK HIST1H2AC ● ● ITGB5 PDLIM1 THBS1 ●

GNG11 WIPF1 ● ● MMD ● ● ● MAX ODC1 RAB31 ITGB3 ● ITGA2B ● KIF2A ● HIST2H2BE ● TAX1BP3 ● ● NRGN TUBB2A ● GNAS ● PIP4K2A ● PGRMC1 PPM1A ● PRKCB F13A1 ● ● ● ENDOD1 PRUNE MYLK RNF11 ● ● MLH3 ● PTGS1 ● PF4 MFAP3L RABGAP1L ● ●RYBP● ● ● ● ● ● PTPN12 TPM1 ● APP ● TSC22D1 MPP1 PPBP PF4V1 LEPROT ● GLA ● ● ● ●PRDX6 ● SNN ZNF185 ● ● ● FHL1 ● CXCL5 CTSAASAH1 ● SNCA TNFSF4 ● ● ●RGS10 ●● ● EIF2AK1 PRKAR2B ● TUBA4A ● CCL5 ●● ● SPARC VCL HBB● ● ● CTTN ●

●

Pathway: RODWELL_AGING_KIDNEY_DN There are 84 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ADCY1 Weight Factor: 1.294 Major Gene (NEG): LRPPRC Weight Factor: 1.145

NEG ALL Major Gene (NEG): LRPPRC Weight Factor: 1.416 Major Gene (BCR/ABL): ADCY1 Weight Factor: 0.891



NEDD4L UAP1 TPD52 ● SULT1C2 RHOBTB3 AMT ● KNG1 ● PTGER3 ● ● ● PCLO APLP2 ●DBT● MPPED2 AUTS2 CCDC93 ●CPEB3 ABTB2 ● SLC25A36 ● ● ESRRG ● SP2 KLF9 PHYH ● ● CLDN8 SELENBP1 FMO5 ● ZNF711 ● TMPRSS2 ● EGF● GHR ● ATP5A1 ●SLC16A7 SLC4A1 ●GPRASP1 ● ZNF253 SHANK2 ADCY1 ● ● FBXO21 ● ● ● ● ● NDUFS1 LPL●● ● GAD1 ● ISCA1 ●GNAS PRKAA2 ● ADH5 CTH ERLIN2 HADHB ● ● ● ●PALM ● ● ● MTR BMP7 ●ATP5G3 ● ● NEBL THSD7A ● OATCRABP1 AASS ● ● NF1 ● ● ● MUT TSPAN7 ENOSF1 ● RTN4 ● ● ●FXR1 ● SIAH2 BCKDHB WNK1 LRPPRC ● ● ● ● ABCA5 DLAT HDAC6● ● ● COX7C ZBTB43 LDHB PPFIA1 ● COX7B OXCT1 ● ● ● TOX3 ●GNG7 CYCS ● ● ● ● ● WDR61 ● GOT2 ● AK2 GABARAPL1 ● AMPD3 ● ● ●CACNB2 PEBP1 ● ●

● ●

ZNF711 SHANK2 ●THSD7A ● LPL ● CTH TPD52 ESRRG GAD1 WNK1 ● ADCY1 ● ●ERLIN2 ●● ● ●FMO5 SLC16A7 WDR61 GPRASP1 ● TOX3 ●DBT ZNF253 PCLO HDAC6 ● ● ABCA5 ● ENOSF1 ● BCKDHB ● ● ● ATP5A1 ● RHOBTB3 ● NEDD4L TSPAN7 ● PEBP1 NF1 ● ● ● AK2 PTGER3 PHYH●GHR ● ZBTB43 ● GOT2 ●● ADH5AMPD3 ● OXCT1 GABARAPL1 ● ● ● CYCS CRABP1 CLDN8 ● MPPED2 ● ● LDHB APLP2 ● COX7B ● SIAH2 NDUFS1COX7C ● ● MUT ● ●ATP5G3 KLF9ABTB2 ● ● UAP1 LRPPRC ● ● FBXO21 ● ●● ● PPFIA1 ● ● MTR SELENBP1 AMT ●HADHB ● ● BMP7 CPEB3 DLAT ● AASS SLC4A1 ● RTN4 ● GNAS ● GNG7 ● ● ISCA1 ● KNG1 ● ● ● SULT1C2 ● NEBL ● EGF ●TMPRSS2 ● PRKAA2 ●SLC25A36 OAT FXR1 ● ● ● PALM ● ● ● ● CACNB2 ●AUTS2 CCDC93 SP2 ●

●

●●

●

Pathway: KAYO_CALORIE_RESTRICTION_MUSCLE_DN There are 66 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HADHB Weight Factor: 1.4 Major Gene (NEG): MDH1 Weight Factor: 1.375

NEG ALL Major Gene (NEG): MDH1 Weight Factor: 1.481 Major Gene (BCR/ABL): HADHB Weight Factor: 1.401



MBTPS1 ACTN1 DDO TSPAN7

DDO

CREM ● MNAT1 ● RAB4AMRPL23

●

●

●RANBP1 ECH1

RGS3 TAZ ● CKMT2

● ACAA2 ● SNRNP27 ● ●DDX17 KAT5 HADH ●PRPS1L1 A XIN1 MYOC RAB2A RAPGEF3 ● ● KRT5 ● ● ● ●● ● ● MBTPS1 GOLGA3● PIAS1 PNLIPRP2 ● TSPAN7 CGREF1 ● NNT SLC23A2 ADCY2 ● MPI ●CRYAA ● ● ● ● COX4I1 ● BMP6 TNP1 ● ● VDAC2 PEX19 ● ● ELL ● RRS1 GNAQ PSG9 ● MDH1● ● RHCE HADHB ● SMOX FBP2 ● CDR2L ● ACTN1 ● KDM5C ● UQCRC2 ● GOT2 ● ● NDUFV2 ● ● HLA−DMAATF6B ● RUNX2 COPB2 ● SERINC3 ● BAK1 ● ACR ● ● ●DYNLT1 RCAN1● ● POU2F2 ● ● SUB1 ● TSNAX ABCC2 ● ● ● GLI3 ●● ●

● NDUFV2 BAK1

● ●

● ●●

RCAN1

●

COX4I1 ACR RAB4AATF6BPSG9 SUB1 PNLIPRP2 CRYAA PIAS1 ● GNAQ● ● ● ● FBP2DDX17 ● ● GLI3● RUNX2 ● ● ● TNP1 ● ABCC2 ● GOT2 PEX19 ● DYNLT1 CDR2L ● UQCRC2 ELL ● SERINC3 TSNAX ● POU2F2 ● ● PRPS1L1 MRPL23 ● ● COPB2 KAT5 HADHB ● SLC23A2 ● ● MNAT1 ● ●ACAA2 ● RHCE ●CGREF1 ● ● ● CREM ● ● MYOC KRT5CKMT2 ● ADCY2 VDAC2MDH1 MPI SNRNP27 RRS1 NNT ● ● ● ● RGS3 ● ● ECH1 ● ● ●KDM5C ● ● ● RAPGEF3 AXIN1 ● RANBP1 ● BMP6 ● HLA−DMA ●GOLGA3RAB2A SMOX● ● ● HADH ● ● ● ● TAZ ●

●

Pathway: LIANG_SILENCED_BY_METHYLATION_UP There are 18 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): TIMP3 Weight Factor: 1.416 Major Gene (NEG): ASAH1 Weight Factor: 0.882

NEG ALL Major Gene (NEG): ASAH1 Weight Factor: 1.46 Major Gene (BCR/ABL): TIMP3 Weight Factor: 1.367



MFAP5

MYH3 ASAH1 KRT8

STAT1

●

AQP1

● SCG5

●

MFAP5 SRGN

●

STAT1

●

●

●

●

●

IFI27

SCG5

●

MMP3

●

●

●

KRT8

● ASAH1

LGMN

● ALDH1A3 ●

TNFSF4 AQP1

●

●

MMP3 COX7A1

●

LGMN

●

●

HIST1H2AC

●

● TNFSF4

● KRT19 CCND2

●

●

CCND2●

●

TIMP3

●

KRT19

●

IFI27

●

●

ALDH1A3

HIST1H2AC

● TIMP3

SRGN

●

MYH3

●

COX7A1

●

Pathway: KAAB_FAILED_HEART_ATRIUM_DN There are 138 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): MCM3 Weight Factor: 1.468 Major Gene (NEG): PGK1 Weight Factor: 1.321

NEG ALL Major Gene (NEG): PGK1 Weight Factor: 1.389 Major Gene (BCR/ABL): MCM3 Weight Factor: 1.129



TNFAIP1 EIF3IDOM3Z FAM131A NUTF2 CD59 PSMB4 PSMD9 CNN3 ● LSM7 ● ● ● ● ● GSTP1 ITM2B ● ●● ● SS18 GDE1 NME2 ● IFNGR1 DDX21 LAGE3 PSMB3● PSMB1 CAPN7●TMEM147 ● ●TGFBR2PSMA3 TMED10 FKBP1A ● ●● TCEB1 ● ● ● DGUOK PLEKHB2 ● ● ●TXN ● RAN WARS ACOT13 CNIH PPM1A HINT1 ●NHP2L1 GTF3A ● RPA1 MPST ● IFITM3 AMD1 GLUD1 ACP1 MAD2L1BP ●● ● ●ACTN1 ● PSMB5 CLIC4 ● SUMO1 ● LDHA MPP1● RAB1A ● MCM3 GRB2 ● ● ●MLEC PRDX1 ● ● ●● ● YWHAE RAD1 ● TPM2 ● ● SRIKIAA0907 PIGH VAT1 ● ●ACTB ● VTI1B ● ●● HNRNPL KIAA0182 UBE2I ●● SLCO3A1 YWHAZ APP USP2 PDCD6 LAPTM4A ● ATP6V0E1 ● STX4 ● ● ● HDGF ● PAFAH1B1●● ZNF22 ● PGK1 ● ●● UBE3C LGMN ● ●●● ● ●TGFBR3 ● TSC22D1 ●RIT1 ● TM9SF1 KPNA6 ST3GAL1 UBA3 CTNNA1● PIR PAPOLA ● SDF2 ● ● TAGLN GSTM3 ●SERPINA3 ● ●CDC16 SMARCA1 ADRM1PLP1 ●PPP1CC ● PODXL ● ●FCN3 ●● DAAM1 ● ●● G3BP2 SLC39A14 ● ● LRBA ● ● PTPRB ● LYPLA1 ●LRRC32 ● ●ABCB6 ● CTTN ● RAB9A SLC9A6 ● EI24 ● NPTNFKBP9 PGM1 ●● ABCC9 MYH10 ●● ● ●BLVRB PARVB ● ● IGSF3 ● STAT3 VAPB● ● ●MAP2K1 ●COL15A1 ● ACOX2 ● ● ● OPTN ACVR1B ● ●● ● PMP22 ● RBP1 ● OSMR SPARCL1 ● ●GPC4 ● RRAGA LRRN3GPR137B ●

●

●● ● ●

●

TGFBR3LSM7 GPR137B ● MPST SDF2 ● FAM131A ADRM1 PSMD9 VTI1B ● ZNF22 ● COL15A1 TM9SF1 ● ACOX2 OSMR RAD1 ● ● MPP1 ● VAT1 ● ATP6V0E1 HINT1 GSTP1● PSMB3 EIF3I ● ●● ● SPARCL1 ● ABCC9 ● LDHA ● GDE1 YWHAE ● RAN●NHP2L1NME2 ● ●PSMA3 ●PSMB5 PSMB4 ●● MLEC ● ● ● MCM3 ● ● ● SLC39A14 LAGE3 TMED10 ●USP2 TXN BLVRB ● PAFAH1B1 ●PRDX1 ●TCEB1 SUMO1 ● PTPRB ● ● HDGF ● ●●RPA1 ● FCN3 PIR PGM1 FKBP1A ● ●FKBP9 CNIH DGUOK ● LRBA ●LRRC32 ● ABCB6 PSMB1 ●GPC4 ● ● ●● ● CNN3 ACOT13 UBE3C PARVB RBP1 RIT1 ● ● ●● LYPLA1 ● ● MAP2K1 ● TMEM147 ● AMD1 CTNNA1 PIGH ITM2B IFNGR1 ●●● TPM2LGMN ACVR1B ● PPP1CC ● ● SLCO3A1 CD59 ● MAD2L1BP ● PLEKHB2 SMARCA1 ACP1 PPM1A DDX21 DOM3Z ● TNFAIP1 NPTN ● ●● IFITM3 ● RRAGAUBE2ICLIC4 ● ● ● LAPTM4A ● RAB1A HNRNPL ● ● KIAA0182 ● OPTN LRRN3 ● ● TGFBR2 ● ● ACTN1 ●VAPB ● ● ● NUTF2 ● ● ● PAPOLA EI24 ● ● WARS PLP1 G3BP2 UBA3 TSC22D1 ● ●STX4 CAPN7 ●PGK1 ●● ● ● ● ● ●YWHAZ PDCD6 ● ● ●● ●SRI●GTF3A APP RAB9A ●CDC16 ● ● PODXL ● ● SERPINA3 SLC9A6 ST3GAL1 ● ● ●GSTM3 KIAA0907 ● GLUD1 ● ACTB ● SS18 GRB2 ● ●KPNA6 STAT3 ● ● DAAM1 ● IGSF3PMP22 CTTN ● TAGLN●● ● ● ● ● ●● ● MYH10 ●●

●

Pathway: IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR There are 24 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): BID Weight Factor: 1.211 Major Gene (NEG): CTSZ Weight Factor: 0.903

NEG ALL Major Gene (NEG): CTSZ Weight Factor: 1.31 Major Gene (BCR/ABL): BID Weight Factor: 0.82



PFKP

●

BID

● CTSZ

GTF3A

● AP3S2

● ERP44

● ELANE

CITED2

GUSB

●

MPO

●

DBI

●

RSU1

●

MAPRE2 SSR2

MPO

● ELANE

RPN1

●

SSR2

●

●

AHCY

● RPN1

●

MAPRE2 AP3S2 CTSZ

●

● UBFD1

●

APEX1

●

UBFD1

●

●

●

●

● CITED2

●

EIF6

GALK1

●

●

●

TMEM97

●

EIF6

●

● WDR77 ● PAPSS2 G3BP1

●

GALK1

AHCY

●

●

●

PAPSS2

●

GTF3A

●

GUSB

●APEX1 ●

DBI

TMEM97 G3BP1● WDR77 ●

● BID

●

ERP44

PFKP

●

●

RSU1

●

●

Pathway: IVANOVA_HEMATOPOIESIS_MATURE_CELL There are 78 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): EPS15 Weight Factor: 1.394 Major Gene (NEG): XPO7 Weight Factor: 0.984

NEG ALL Major Gene (NEG): XPO7 Weight Factor: 1.45 Major Gene (BCR/ABL): EPS15 Weight Factor: 1.177



BNIP3L RHD ● ● SDCBP SNCA ALAS2 RHAG SLC4A1 MKRN1 GYPA ● FPR1GOLIM4 ● ●● RAB6A ● MGST3 ● ● SLC16A1 ● ●● MMP8 STX2 SRI SCD ● ACSL1 HAGH BMP2K MPP1 ● ● GRINA ● ● ● TSPAN8 ATP6V1E1 CDK8 USP7● ● ● ● ● CCNA2 XPO7 GPX4 LILRB3 CDR2 ● ● ● SLC1A5 ● ● MRC1 PGLYRP1 ● LGMN ●EGFR ●CYBB PIGQ● ● CTSH EPS15 PPP3R1 ST3GAL5 ● ITGAM ● CDKN3 CTSB RBMS1 ● CD14 ● ● ● ● DCK ● EMR1 ● NR2F6 UBAC1 ● ● ●RNF167 ● ADD1 ● TMPO ● ●ACP5 ● ●COL1A1 TCEA1 ● PPOX GTF2A1 ● ● FPR2 ●HTATIP2 ACP1 ● ● AMPD3C1QB AGFG1● ●EPOR ●ARL2BP MTHFD2 DEGS1 ● SLC11A1 ASNS ● ● ● ●● ● ● ● SLC7A8 ●● ● ACTA2 ● GCNT1 LAMP2 ● GADD45A ● ● TLR6 ●

●

GPX4 CDK8 CYBB ● GCNT1 ● RNF167 ● ASNS ACTA2 ● TSPAN8 ACSL1 RAB6A ● EPOR ● ● AGFG1GOLIM4 ●LILRB3 ● CTSB ● ● ● ● RBMS1 GADD45A ● USP7 ● GTF2A1 SLC1A5 ST3GAL5 ● ● ● ● FPR1 BMP2K ● CDR2 MKRN1 SCD PPP3R1 ● ACP1 ●● ● ● EGFR ●ADD1 ● C1QB TMPO ● ● PIGQ ●● FPR2PPOX ARL2BP CDKN3 MTHFD2 ● ● MPP1 PGLYRP1 ● ACP5 GRINA ● CCNA2 ITGAM ● MMP8 ●● HAGH ● ● ● SLC7A8 EPS15 ● EMR1 ● UBAC1 SLC16A1 MGST3 ● ● ● ● TCEA1 ●● ● ● ● NR2F6● ●BNIP3L STX2 COL1A1 HTATIP2 CTSH DEGS1 ● SNCA ●● ●ATP6V1E1 ● DCK CD14 LAMP2 RHAG ● ● ● TLR6 ALAS2 ● ●AMPD3 SRI ● ●SLC4A1 ● ● ● ●XPO7 LGMN● ● ● MRC1 RHD ● GYPA SLC11A1 SDCBP

●

●

●

●

Pathway: DASU_IL6_SIGNALING_SCAR_DN There are 16 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HMOX1 Weight Factor: 1.2 Major Gene (NEG): HMOX1 Weight Factor: 1.2

NEG ALL Major Gene (NEG): HMOX1 Weight Factor: 1.372 Major Gene (BCR/ABL): HMOX1 Weight Factor: 1.372



PPP1R3C

TPM1

●

● PDGFRA

CYR61 PSG9

●

●

SULF1

● ADAM10SGK1

●

CTGF

●

●

HMOX1 ● ●

SULF1

●

TMBIM6

CYR61

●

SGK1

●

ID3

●

SERPINE1

PRPS1

●

THBS1

●

THBS1

● PSG9

●

LOXL2

●

●

● PDGFRA

●

● CTGF

TMBIM6 ID3

●

TPM1

LOXL2

●

PRPS1

●

●

ADAM10

●

HMOX1

●

●

PPP1R3C

SERPINE1

●

●

Pathway: MMS_MOUSE_LYMPH_HIGH_4HRS_UP There are 29 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): VBP1 Weight Factor: 1.303 Major Gene (NEG): ATP6V1A Weight Factor: 1.162

NEG ALL Major Gene (NEG): ATP6V1A Weight Factor: 1.384 Major Gene (BCR/ABL): VBP1 Weight Factor: 1.328



SP3

RRM2

●

● PLK4 CDC6

DCK

MARK2

●

LYPLA1 XBP1● PSMA3

●

● NQO1 ●

●

EIF4A2

● RBBP6

●

TXNRD1 CXCR4

● PTDSS1

●

PGRMC1

● HMGB3ACTG1 RBBP7 HNRPDL ATP6V1A ● ● ● ● CYB5A VPS4B ● RCN2 FEN1 ● ● PGRMC1 ● ● LMO4 ● ● VBP1 EIF1AY ●

CXCR4

●

●

● ●

●

LMO4

PRKAR1A

●

PLK4

● EIF1AY EIF4A2 NQO1LYPLA1 ● ● ● ●

●

RRM2

MARK2

●

●

DCK

●

XBP1 RBBP6

●

● FEN1

● CDC6

●

PSMA3 VBP1

●

●

ATP6V1A

●

RCN2

● PRKAR1A ACTG1 ●

● CYB5A

● PTDSS1 SP3 ● TXNRD1 ● RBBP7 ● HMGB3 ● HNRPDL ● ●

VPS4B

●

Pathway: BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_UP There are 18 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IGF1 Weight Factor: 1.344 Major Gene (NEG): ARSF Weight Factor: 1.121

NEG ALL Major Gene (NEG): ARSF Weight Factor: 1.183 Major Gene (BCR/ABL): IGF1 Weight Factor: 1.169



SEMA3A

RABGAP1L MYOF

●

●

SGCE MDK

ENC1●

MYOF

CA2

●

●

●

FBXO21

●

IGF1

● HTRA1

● ●

MDK PPP2R1B ●

●

●

TPM1

●

●

LMO2

●

CYR61

● ID2

●

●

● HTRA1

●

ARSF

SHOX2 CYR61 ● CDH11 ●

PPP2R1B

●

●

●

●

●

TPM1FBXO21

●

●

● SEMA3A

SHOX2

RABGAP1L ENC1

ID2

IGF1

ARSF

●

LMO2

●

CA2

●

SGCE

● CDH11

●

Pathway: GENTILE_UV_RESPONSE_CLUSTER_D7 There are 31 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): CTDSP2 Weight Factor: 1.338 Major Gene (NEG): MORC3 Weight Factor: 1.178

NEG ALL Major Gene (NEG): MORC3 Weight Factor: 1.384 Major Gene (BCR/ABL): CTDSP2 Weight Factor: 1.258



PPAP2B

GBAS

CDK8

● PRKCD CUL1 SPOP ● PPAP2BTRIP10 FBXO46 JUND ● CTDSP2 ● TNFRSF1A ● ● ● RARS RABGAP1 ● ● ● KIAA0494 ● STX7 RAB11A PTPN1 ● ● MORC3 ● CDK8 ● CASP8 ● ● TLE1

PTPN1

●

●

●

RBMS1

●

●

EMG1 CDK14

●

●

PGRMC2

●

● NASP

●

● ●

IL4R

●

TBL1X

●

CASP8

LSM2

RABGAP1

RAB11A

● CEBPD

●

RBMS1

●

MET

CEBPD●

●

TRIP10

●

MET

●

●

PMP22

LSM2

●

● RARS

NASP

●

EMG1

●

● PMP22 TLE1 ●MORC3 ● SPOP● ● GBAS ● FBXO46 ● CUL1 STX7 ● ● ● KIAA0494 ● TNFRSF1A CTDSP2

TBL1X

●

●

PGRMC2

JUND ● ●

IL4R

●

●

PRKCD

●

CDK14

●

Pathway: ZUCCHI_METASTASIS_UP There are 18 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): H2AFZ Weight Factor: 1.367 Major Gene (NEG): H2AFZ Weight Factor: 1.367

NEG ALL Major Gene (NEG): H2AFZ Weight Factor: 1.382 Major Gene (BCR/ABL): H2AFZ Weight Factor: 1.382



AHCY

EDN2

●

CTGF

●

AHCY

●

PTMA

●

CYFIP1

PPIA

HSPA8● TGFA● H2AFZ ●

GNG11 GNB2L1 ●

●

TPT1

PPIA

●

●

●

HSPA8 CTGF

CCT5

●

●

IFITM3

●

●

●

IFITM3

●

STEAP1

LDHA

●

FSCN1

●

TPT1 ● HMGB1

●

FSCN1

●

●

HMGB1 PTMA

● LDHA

H2AFZ

CCT5

●

●

●

● ●

EDN2

●

●

● STEAP1

GNG11 CYFIP1

●

GNB2L1 TGFA

●

●

Pathway: ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION There are 85 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): FNBP1 Weight Factor: 1.4 Major Gene (NEG): JAK1 Weight Factor: 1.37

NEG ALL Major Gene (NEG): JAK1 Weight Factor: 1.587 Major Gene (BCR/ABL): FNBP1 Weight Factor: 1.088



CSNK1E

HES1 ● ID2

●

EGR2 CDH11 CSPG5GPSM3 CDK14 SH2B3 ZDHHC3 ● ● ARHGEF1 CEBPB RHOH ● ME1 ● ● CD79A ● ● ● HIPK1 ● GLG1 ● ● ● GABARAPL1 FOS WNT5A CAV2 VWA5A ● WDR47 CRIP2 IPO13MYC ● SLC1A4 ● ● XPNPEP1 GLCE CAV1 ● UAP1 ● ● ● RCOR1 ●JAK1 ● CCND1 ● CITED2 ATP1A1 ● MAN2A2 ● ● FNBP1 ● ● ● ● ●FCGRT ADO ● MAPT IL1RAP ● ● PPFIA3 CSNK1E CCBL1 CSRP1 ● DPYSL2 ●IFITM1 KDSRPSEN1● TRIM2 ● ● ● ● CCK MSX1 ● ● HOXD9 ●SMARCC1 ● ● SIRPA SEL1L3 ● ● SLC17A7 ● PFKP ● HLA−ECD99 ST6GAL1 ● ●NPTXR ● SORD● FADS1 ● STARD13 ● OLFM1 STEAP1 ● IGFBP4 ●DAPK1 ● ● ●STAT6 RAP1GAP ● ● ● ● UBXN7 ●RNF113A ●RUNX3 SYT1 ● ● ● ● GYG2 NELL2 MYO10 CD1E LY96 ● CHN2 ● ATF5 ● ● G0S2 ● ● ● ●PRKCB ● ● GRK5

●

CHN2

SLC1A4 XPNPEP1 UAP1 RUNX3 HLA−E ● CD99 ● G0S2 SYT1 UBXN7 ● ● ●FOS ●PFKP HES1 ● ● ● SORD IFITM1 CEBPB CDK14 ● NELL2 ● SMARCC1 ● ● ● ● GRK5 ● DPYSL2 TRIM2 SH2B3 ● GLG1 ● ● ●ZDHHC3 EGR2ATP1A1 ADO ●●GPSM3 ●● ● ● CCND1 MYC CSRP1 ● RAP1GAP RCOR1 ●MAN2A2 WNT5A FADS1 ● SIRPA ●● PRKCB WDR47 DAPK1 CAV2 CDH11 ● ● ● VWA5A NPTXR ● ●● STARD13 CCK JAK1 MSX1 ● FNBP1 STAT6 SEL1L3 ● ● ●OLFM1 ● ● LY96 ●CD1E ● ● IPO13● CRIP2 ● CAV1 ● ● STEAP1KDSR HOXD9 ● ● ST6GAL1 ● ● RHOH ● ● MYO10 ●GYG2 CCBL1 ● FCGRT ● ● RNF113A PSEN1 MAPT ● ● PPFIA3 ● ● CSPG5 ●● SLC17A7 ● ● ● CITED2 HIPK1 ME1 ● IL1RAP ATF5 ● GLCE●ID2 ● ● ● IGFBP4 CD79A● ● ● ● ● ARHGEF1 GABARAPL1

●

●

●

●

●

●

Pathway: KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION There are 40 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ROCK1 Weight Factor: 1.321 Major Gene (NEG): NCK2 Weight Factor: 1.015

NEG ALL Major Gene (NEG): NCK2 Weight Factor: 1.395 Major Gene (BCR/ABL): ROCK1 Weight Factor: 0.985



TUBB2B

RHOATUBB2A

●

● CDC42 ●

●

ARPC5 NCL CTTN ROCK1 YWHAQ HCLS1 ● ●

● ABL1 TUBA4A

●

●

TUBA3D NCL

●

CTNNB1 OCLN ● ARPC2

ARPC4 ● EZR ● ARHGEF2 ● ● ACTB ● TUBB2B KRT18 ACTG1 ITGB1 ● YWHAZ ● TUBB3

●

●

● PRKCA ARPC1A ●

FYN

●

WAS

ROCK2

●

CDH1

●

● TLR5

●

●

●

●

TUBA3D

TUBB

●

●

NCK2 TUBA1B ● ARPC3

●

●

●

● ●

● ●

CDH1 ● ARPC5 EZR

WAS

WASL LY96 NCK1 CD14 ●

●

●

●

FYN ROCK2 ● ARPC1A

●

●

TUBB3 ACTG1

● TUBA1B ● ●

●

CDC42

● TUBB2A

●

● TUBB

TLR5

●

●

RHOA TUBA4A

●

ROCK1

●

YWHAQ ● ITGB1 ● ● ARHGEF2 ARPC4 ● WASL ABL1 ● OCLN ●NCK2 CTTN ● ● ● ●

●

HCLS1 ARPC3

●

●

PRKCA

●

YWHAZ ACTB CTNNB1 ● ● ARPC2

LY96

●

●

KRT18 NCK1 CD14 ●

●

●

Pathway: BIOCARTA_ECM_PATHWAY There are 24 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ROCK1 Weight Factor: 1.49 Major Gene (NEG): ITGB1 Weight Factor: 0.851

NEG ALL Major Gene (NEG): ITGB1 Weight Factor: 1.374 Major Gene (BCR/ABL): ROCK1 Weight Factor: 1.204



ARHGAP5

PFN1

●

●

GSN

PIK3R1 TLN1

PIK3CA

●

SHC1

●

●

HRAS

●

MAPK1

●

●

PTK2

●

ITGB1

●

●

●

GSN

● PTK2

PXN MYL2

●

PXN

●

ARHGAP5

●

RHOA

● ITGA1

●

● RAF1

●

PIK3CG

●

●

ITGB1

● MAPK3

ITGA1

● SRC

HRAS

●

● MYLK

●

FYN

●

● MAPK1

●

●

●

●

●

RHOA

ROCK1 PIK3CA

● ●

PFN1 RAF1

MAP2K1

●

●

SHC1

FYN

PIK3CG

DIAPH1

●

MYL2

●

ROCK1

●

●

●

MAP2K1

●

SRC

MAPK3

TLN1 PIK3R1

DIAPH1

●

●

● MYLK

●

Pathway: BIOCARTA_MYOSIN_PATHWAY There are 29 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): ROCK1 Weight Factor: 1.452 Major Gene (NEG): ARHGEF16 Weight Factor: 1.302

NEG ALL Major Gene (NEG): ARHGEF16 Weight Factor: 1.384 Major Gene (BCR/ABL): ROCK1 Weight Factor: 1.236



ARHGEF1

●

GNA12

●

PKN1

ARHGEF4 ● GNAQ ● ● ARHGEF17

● PRKCA

●

ARHGEF5

●

●

ARHGEF18 ARHGEF5 ● ARHGEF11 ARHGEF12

●

●

● ●

●

GNA12 PPP1R12B ARHGEF1

●

●

●

PRKCB

ARHGEF2 ● ● ARHGEF9 ARHGAP5 ● ARHGEF7 ● ● ● ARHGEF10

●

●

●

●

● ●

MYL7

ARHGEF15

●

ARHGEF10

GNA13 ARHGEF18 ● ARHGAP5 ARHGEF6 ARHGEF16 ARHGEF9

●

GNA13

●

●

●

GNGT1

●

PKN1

●

MYL2

● ROCK1 GNB1 ● MYL7 ● ARHGEF16●

GNGT1

●

PRKCA

PLCB1

ARHGEF2 ARHGEF4

ARHGEF6

ARHGEF15 MYLK●

PLCB1

●

PPP1R12B

MYLK

●

●

● ●

GNAQ

●

ARHGEF11

●

●

ARHGEF17

●

●

●

ARHGEF12 ROCK1 MYL2

PRKCB

●

GNB1

●

ARHGEF7

●

Pathway: BIOCARTA_LONGEVITY_PATHWAY There are 15 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): HRAS Weight Factor: 1.321 Major Gene (NEG): SOD1 Weight Factor: 1.257

NEG ALL Major Gene (NEG): SOD1 Weight Factor: 1.392 Major Gene (BCR/ABL): HRAS Weight Factor: 1.163



SHC1

GH1

●

● FOXO3

PIK3CA

●

PIK3CA

AKT1

●

●

HRAS

●

●

IGF1R

●

PIK3R1

PIK3CG

SOD2

● ●

IGF1 SOD1

●

SOD3

●

●

●

●

●

●

SOD2

HRAS

IGF1R

●

GH1

● PIK3CG

●

●

SOD3

● SHC1

● ●

GHR

SOD1

PIK3R1

●

CAT

GHR

CAT

●

AKT1

●

IGF1

●

● FOXO3

●

Pathway: REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL There are 81 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PPIL2 Weight Factor: 1.449 Major Gene (NEG): PTPN11 Weight Factor: 1.253

NEG ALL Major Gene (NEG): PTPN11 Weight Factor: 1.599 Major Gene (BCR/ABL): PPIL2 Weight Factor: 1.532



SLC16A1 PTPN6 SLC3A2 ● LYN NRAS PIK3R1SLC7A5 ● ● SHC1 LCK ● ● ● ITGB2 GRB7 MERTK OLR1 ● ● PIK3CA ITGAV ● ●CXADR ITGA5 ● ● ITGA6 ● YES1 ● ITGAL TEK ● ● ANGPT1 ● ● ● CD47 ● CD84 ● PIK3CB GRB2 L1CAM COL1A2 KRAS HRAS ● PF4V1 ● ● PPIA ● SLC7A11 ● ● SLC7A6 PROS1 ● ● FYN ● BSG ● THBD ATP1B2 ● PROC ● ● ITGB3 ●● GRB14 ●MMP1 CD58 ● ● SELL ATP1B3 SRC ● MAG PTPN11 SELP● ● ● PECAM1 PIK3R2 ● CAV1 ● SLC7A8 ● COL1A1 ● ● INPP5D DOK2 ● ATP1B1 ● SOS1 PF4 CD2 ● SPN● ● ● ● ITGB1 ANGPT2 ● ● ● ● ● ● SELPLG ●ITGA4 SIRPA SLC7A7 ●PPIL2F2●PLCG1 ● ● ITGAX ● GAS6 ● ● ITGA3 FCER1G ● APOB ● ● ● ● ITGAM ● CD48 ●JAM3 FN1 ● SLC16A3

●

●

● ●

PIK3R1

ITGAX THBD ● PECAM1 PTPN6 ● ● ITGAM LYNANGPT2 FCER1G ●GRB2 ● ● ● LCK●ITGB2 SELL ● ● CD58 GAS6 SLC7A6 ●PF4 ● SOS1 ● ● NRAS ITGA4● FYN SPNSLC16A3 ●● ●● ATP1B1CD48 GRB14 ITGA5 ● ● ● ● ● ITGB3 COL1A1 ● ATP1B3 ● HRAS INPP5D ● GRB7 SIRPA SELP ● KRAS ● ●PTPN11 ● ● ●● PF4V1 ATP1B2SHC1 SLC7A7 ●BSGPPIL2 DOK2 ● MAG SRC PLCG1 ● PIK3R2 ● ITGA6 PIK3CA ● CD47 ●ITGAL ● ● ● ● ● PROS1 ● PPIA ● PROC SLC16A1 TEK ●● ● ● JAM3OLR1 ANGPT1 ●ITGB1 ● SLC3A2 ● F2 ● ITGA3 ● COL1A2 CD84 FN1●YES1● ● ● ● ●SLC7A8 ●CXADR ● ● ● ● PIK3CB● MMP1 ● ● L1CAMCAV1 SLC7A11 APOB ● MERTK ● ● ● ITGAV CD2 ● ● ● SELPLG ● ● SLC7A5

●

●

Pathway: REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION There are 20 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): IARS Weight Factor: 1.273 Major Gene (NEG): IARS Weight Factor: 1.273

NEG ALL Major Gene (NEG): IARS Weight Factor: 1.303 Major Gene (BCR/ABL): IARS Weight Factor: 1.303



AIMP1

GARS

●

●

MARS TARS HARS

●

●

SARS

VARS

RARS

●

KARS

●

●

HARS

●

AIMP1

●

● IARS

●

●

EPRS EEF1E1

●

●

CARS

●

●

FARSA

AARS

YARS

RARS

●

CARS NARS

●

●

NARS

TARS

●

●

EEF1E1 KARS● DARS ● IARS ●

YARS

●

●

●

GARS

●

● MARS

AARS

●

WARS

●

● ●

●

●

●

DARS AIMP2● WARS

AIMP2

EPRS

SARS

●

FARSA VARS

●

●

_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_T There are 16 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): AP2S1 Weight Factor: 1.305 Major Gene (NEG): CD8B Weight Factor: 1.194

NEG ALL Major Gene (NEG): CD8B Weight Factor: 1.282 Major Gene (BCR/ABL): AP2S1 Weight Factor: 1.122



AP2B1

CD28

●

AP1S1

●

AP2B1

ARF1

●

●

●

●

AP1S2

●

AP2A2 AP1S2

●

CD4

●

CD8B

● AP2A2

● ●

AP2M1

●

●

ATP6V1H

LCK

●

AP2M1

●

●

● ●

AP2S1

ARF1

AP1G1

●

AP1S1

AP1G1

B2M

●

●

HLA−A ATP6V1H

CD28

●

AP2S1

●

CD4

●

●

CD8B LCK

●

● AP1B1

AP1B1

●

● B2M

●

HLA−A

●

athway: REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESI There are 23 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): AP2S1 Weight Factor: 1.272 Major Gene (NEG): CD8B Weight Factor: 1.198

NEG ALL Major Gene (NEG): CD8B Weight Factor: 1.399 Major Gene (BCR/ABL): AP2S1 Weight Factor: 1.024



RAC1 B2M AP1B1

RAC1

●

ELMO1AP1B1

●

●

● ●

●

●

●

●

LCK

●

PAK2

●

B2M

●

HLA−A AP2B1

●

ATP6V1H ●

● AP1S1

CD28

●

● FYN

●

AP1G1

●

HCK

●

●

●

FYN

●

●

HCK PAK2

AP1G1

● CD4

● ● AP1S2 ELMO1 ● ●

DOCK2

●

ARF1

AP2A2

●

● ATP6V1H

● ARF1

●

CD8B AP1S2

AP2M1

CD247

CD247

●

LCK

●

●

●

●

HLA−A

CD8B

DOCK2 AP2A2 CD4 AP2S1 ●

●

AP2M1 AP1S1 AP2S1

● ●

● CD28

● AP2B1 ●

Pathway: REACTOME_TIE2_SIGNALING There are 17 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): PIK3R2 Weight Factor: 1.336 Major Gene (NEG): PTPN11 Weight Factor: 0.886

NEG ALL Major Gene (NEG): PTPN11 Weight Factor: 1.4 Major Gene (BCR/ABL): PIK3R2 Weight Factor: 1.29



PIK3R1

TEK

●

ANGPT1

NRAS

●

PIK3CB

PIK3CA

GRB2 PIK3R2 KRAS

●

●

SHC1

● PIK3R2

●

●

●

SHC1

●

●

● HRAS

SOS1

GRB14

●

PTPN11

HRAS

ANGPT2

●

●

NRAS

●

●

GRB7

● TEK

●

PIK3R1 ANGPT1

●

●

●

●

●

●

●

GRB14

DOK2 PTPN11

PIK3CB

●

PIK3CA

●

GRB7

●

DOK2 ANGPT2

KRAS

●

●

●

●

SOS1

● GRB2

●

Pathway: REACTOME_TOLL_LIKE_RECEPTOR_4_CASCADE There are 17 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): LY86 Weight Factor: 1.37 Major Gene (NEG): TLR1 Weight Factor: 0.863

NEG ALL Major Gene (NEG): TLR1 Weight Factor: 1.293 Major Gene (BCR/ABL): LY86 Weight Factor: 1.036



RIPK1

TLR5

IRF3

●

●

IRAK1

●

●

MYD88

TICAM1

●

LY86

MAP3K1

●

●

CD180

LBP IRF3

●

● TLR2

CD14

●

IRAK1 TLR6 MYD88

●

TRAF6

●

●

●

● ●

LY96

●

LY96 TRAF6 TLR1● ●

CD180

●

TLR1

●

●

IRAK3

●

●

MAP3K1

● CD14

●

RIPK1

LBP TLR5

●

●

LY86

●

●

IRAK3

●

TICAM1

TLR6

●

● TLR2

●

Pathway: SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES There are 31 genes in this pathway. This pathway was detected by GSCA

BCR/ABL ALL Major Gene (BCR/ABL): GDI2 Weight Factor: 1.461 Major Gene (NEG): LIMK1 Weight Factor: 0.938

NEG ALL Major Gene (NEG): LIMK1 Weight Factor: 1.388 Major Gene (BCR/ABL): GDI2 Weight Factor: 1.306



PFN1FLNA

PAK7

PAK3

PFN2

● ANGPTL2 ●

●

● WASL

VASP

●

ROCK2● MYH2 GDI2●

●

●ACTR2

ACTG1

WASF1

●

PAK4

●

●

●

GDI1

● FSCN1

●

PAK2●

●

●

RPS4X

AKT1 ●

ACTR3

●

● LIMK1

FSCN2

AKT1

●

●

● PAK1CDC42

●

●

●

●

●

PAK1 FSCN1 ROCK2 ●

PFN2 MYH2 ●

●

●

RHO

PAK3

●

●

● PAK7

●

●

WASL

ANGPTL2 MYLK

WASF1

● FLNC

● ACTG2●

●

●

FSCN2

ACTR3 LIMK1

GDI1

ROCK1

●

PAK4

●

● GDI2

RPS4X

●

ROCK1

●

ACTR2

ACTG1

●

CDC42

●

●

● RHO

MYLK

●

CFL1 PAK2●

● ACTG2 FLNC ● PFN1 ● VASP ●CFL1 ● ●

FLNA

● ●

R Graphics Output

R Graphics Output

Suggest Documents